COAGULATION CASCADE PATHWAY (PW:0000474)

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Description

In response to vascular injury, the hemostatic system triggers platelet aggregation and initiation of the coagulation cascade, primary and secondary hemostasis, respectively, to prevent bleeding. The coagulation cascade, initiated via tissue factor - the extrinsic pathway, or contact - the intrinsic pathway, converges into a common pathway leading to formation of insoluble fibrin clots. Sequential activation of zymogens (inert enzyme precursors) and cofactors through limited proteolysis yields t

Pathway Diagram:

Elsevier Inc. Serpinc1 ---| F9a Proc_act_diss pF13a F10a F5a F8a F9a vitamin K-dependent proteins, coagulation F7a F7 Proz ---- Serpina10 tenase complex extrinsic tenase complex Klkb1 --+> F12a F12a --+> Klkb1 protein C anticoagulant pathway Serpina10 ---| F10a Proc_act_diss ---| F5a Proc_act_diss ---| F8a F10 ---- TF/F7a complex extrinsic tenase complex --+> F10a F2a ---> protease mediated signaling pathway F10a ---> protease mediated signaling pathway prothrombinase complex --+> F2a F12 tenase complex ---> F10 F12a --+> F11a F12a ---> F11 F3 ---- F7a F11a ---> F9 F11a --+> F9a Vwf F8 F9a ---> F8 F7 --+> F7a F8 ---- Vwf F12 --+> F12a prothrombinase complex ---> F2 fibrin polymerization, cross-linking --+> fibrinolysis pathway Serping1 ---| F12a Serping1 ---| F11a TF/F7a complex TF/F7a complex --+> F9a F2a --+> fibrin pF13 --+> pF13a pKlkb1 Klkb1 Serping1 ---| Klkb1 F2a ---> fibrinogen F5 --+> F5a Tfpi ---| extrinsic tenase complex fibrinolysis pathway ---> fibrin pF13a --+> fibrin polymerization, cross-linking F10 F2 F5 tenase complex --+> F10a Serpinc1 ---| F2a Serpinc1 ---| F10a protease mediated signaling pathway F11 F9a --+> F8a F9 prothrombinase complex F2a pF13 fibrin fibrinogen fibrin polymerization, cross-linking vitamin K cycle pathway kallikrein-kinin cascade pathway F3 Proz Serpina10 Serpinc1 Tfpi Serping1 F12a F11a fibrinolysis pathway
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coagulation cascade pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:6907045
G Apoh apolipoprotein H JBrowse link 10 96,640,013 96,653,939 RGD:1578489
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:6907045
G Bdkrb2 bradykinin receptor B2 JBrowse link 6 129,399,468 129,429,676 RGD:6907045
G C1qa complement C1q A chain JBrowse link 5 155,261,254 155,264,101 RGD:6907045
G C1qb complement C1q B chain JBrowse link 5 155,246,444 155,251,995 RGD:6907045
G C1qc complement C1q C chain JBrowse link 5 155,255,013 155,258,631 RGD:6907045
G C1r complement C1r JBrowse link 4 157,126,060 157,136,825 RGD:6907045
G C1s complement C1s JBrowse link 4 157,143,592 157,155,592 RGD:6907045
G C2 complement C2 JBrowse link 20 4,542,340 4,561,152 RGD:6907045
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:6907045
G C3ar1 complement C3a receptor 1 JBrowse link 4 155,681,767 155,691,240 RGD:6907045
G C4b complement C4B (Chido blood group) JBrowse link 20 4,302,344 4,316,752 RGD:6907045
G C4bpa complement component 4 binding protein, alpha JBrowse link 13 47,342,090 47,377,580 RGD:6907045
G C4bpb complement component 4 binding protein, beta JBrowse link 13 47,387,173 47,398,115 RGD:6907045
G C5 complement C5 JBrowse link 3
3
14,049,993
14,206,466
14,113,931
14,229,141
RGD:6907045
G C5ar1 complement C5a receptor 1 JBrowse link 1 78,186,777 78,195,132 RGD:6907045
G C6 complement C6 JBrowse link 2 54,460,333 54,533,801 RGD:6907045
G C7 complement C7 JBrowse link 2 54,707,621 54,781,624 RGD:6907045
G C8a complement C8 alpha chain JBrowse link 5 124,348,536 124,403,117 RGD:6907045
G C8b complement C8 beta chain JBrowse link 5 124,298,269 124,338,055 RGD:6907045
G C8g complement C8 gamma chain JBrowse link 3 2,724,616 2,727,616 RGD:6907045
G C9 complement C9 JBrowse link 2 55,775,562 55,823,807 RGD:6907045
G Cd46 CD46 molecule JBrowse link 13 113,786,525 113,818,741 RGD:6907045
G Cd55 CD55 molecule, decay accelerating factor for complement JBrowse link 13 47,125,156 47,153,557 RGD:6907045
G Cd59 CD59 molecule JBrowse link 3 94,010,481 94,028,660 RGD:6907045
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:6907045
G Cfd complement factor D JBrowse link 7 12,634,216 12,635,939 RGD:6907045
G Cfh complement factor H JBrowse link 13 56,979,155 57,080,540 RGD:6907045
G Cfi complement factor I JBrowse link 2 235,264,149 235,305,779 RGD:6907045
G Cpb2 carboxypeptidase B2 JBrowse link 15 57,290,849 57,339,762 RGD:6907045
G Cr1l complement C3b/C4b receptor 1 like JBrowse link 13 113,824,886 113,872,097 RGD:6907045
G Cr2 complement C3d receptor 2 JBrowse link 13 113,890,274 113,927,824 RGD:6907045
G F10 coagulation factor X JBrowse link 16 81,803,169 81,822,476 RGD:1580376
RGD:2290183
RGD:6907045
RGD:11342779
RGD:11352277
G F11 coagulation factor XI JBrowse link 16 50,179,458 50,201,644 RGD:2290183
RGD:11342779
RGD:11352277
G F12 coagulation factor XII JBrowse link 17 9,736,577 9,744,420 RGD:2290183
RGD:6907045
RGD:11342779
RGD:11352277
G F13a1 coagulation factor XIII A1 chain JBrowse link 17 28,504,650 28,680,015 RGD:6907045
RGD:11352259
G F13b coagulation factor XIII B chain JBrowse link 13 56,598,891 56,623,132 RGD:6907045
RGD:11352259
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:1578509
RGD:2290183
RGD:6907045
RGD:11342779
RGD:11352277
G F2r coagulation factor II (thrombin) receptor JBrowse link 2 26,118,760 26,135,340 RGD:6907045
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6907045
RGD:11342779
RGD:11352277
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:1580372
RGD:2290183
RGD:6907045
RGD:11342779
RGD:11352277
G F7 coagulation factor VII JBrowse link 16 81,824,610 81,834,923 RGD:1580376
RGD:2290183
RGD:6907045
RGD:11342779
RGD:11352277
G F8 coagulation factor VIII JBrowse link 18 367,862 399,242 RGD:1582368
RGD:2290183
RGD:6907045
RGD:11342779
RGD:11352277
G F9 coagulation factor IX JBrowse link X 143,097,507 143,141,791 RGD:1580376
RGD:2290183
RGD:6907045
RGD:11342779
RGD:11352277
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:6907045
RGD:11352259
G Fgb fibrinogen beta chain JBrowse link 2 182,028,044 182,035,026 RGD:6907045
RGD:11352259
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:6907045
RGD:11352259
G Klkb1 kallikrein B1 JBrowse link 16 50,151,127 50,175,407 RGD:6907045
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:6907045
G Kng2l1 kininogen 2-like 1 RGD:6907045
G Masp1 mannan-binding lectin serine peptidase 1 JBrowse link 11 80,736,424 80,806,278 RGD:6907045
G Masp2 mannan-binding lectin serine peptidase 2 JBrowse link 5 165,415,105 165,429,857 RGD:6907045
G Mbl1 mannose-binding lectin (protein A) 1 JBrowse link 16 18,736,154 18,742,193 RGD:6907045
G Mbl2 mannose binding lectin 2 JBrowse link 1 248,435,069 248,442,669 RGD:6907045
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:6907045
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:6907045
G Plaur plasminogen activator, urokinase receptor JBrowse link 1 81,328,171 81,344,954 RGD:6907045
G Plg plasminogen JBrowse link 1 48,521,828 48,563,895 RGD:6907045
G Proc protein C JBrowse link 18 24,918,402 24,928,822 RGD:6907045
RGD:11352277
G Pros1 protein S (alpha) JBrowse link 7 1,206,648 1,288,140 RGD:6907045
G Proz protein Z, vitamin K-dependent plasma glycoprotein JBrowse link 16 81,784,348 81,797,889 RGD:11352284
G Serpina1 serpin family A member 1 JBrowse link 6 127,610,241 127,632,265 RGD:6907045
G Serpina10 serpin family A member 10 JBrowse link 6 127,500,014 127,508,470 RGD:11352284
G Serpina5 serpin family A member 5 JBrowse link 6 127,753,152 127,772,403 RGD:6907045
G Serpinc1 serpin family C member 1 JBrowse link 13 78,806,107 78,820,375 RGD:6907045
RGD:11352277
G Serpind1 serpin family D member 1 JBrowse link 11 87,913,814 87,924,880 RGD:6907045
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6907045
G Serpinf2 serpin family F member 2 JBrowse link 10 62,264,247 62,272,353 RGD:6907045
G Serping1 serpin family G member 1 JBrowse link 3 72,161,230 72,171,109 RGD:6907045
RGD:11342779
RGD:11352277
G Tfpi tissue factor pathway inhibitor JBrowse link 3 71,852,738 71,902,127 RGD:6907045
RGD:11342779
RGD:11352277
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:6907045
G Vwf von Willebrand factor JBrowse link 4 158,085,059 158,219,525 RGD:6907045

Pathway Gene Annotations

Disease Annotations Associated with Genes in the coagulation cascade pathway
Disease TermsGene Symbols
Abortion, HabitualF5 , Thbd
Abortion, SpontaneousF11 , F12 , F13a1 , F3
Abruptio PlacentaeProc
Acidosis, LacticPlat
Acquired AngioedemaF12 , F2 , F7 , Kng2 , Serping1
Activated Protein C ResistanceProc , Pros1 , Tfpi
Acute Coronary SyndromeF12 , F2 , Serpinc1
Acute Kidney InjuryA2m , Bdkrb2 , Fga , Kng2 , Plat , Proc , Serpinc1 , Thbd
Acute Lung InjuryC3 , F2 , F3 , Fga , Plau , Proc , Serpinc1 , Serpine1 , Serping1 , Thbd
Acute Traumatic CoagulopathyPlat
AdenocarcinomaPlau , Serpina1
Adenoma, Liver CellA2m
Adenomatous Polyposis ColiF5
AfibrinogenemiaCfi , Fga , Fgb , Fgg
Airway ObstructionPlat , Tfpi
AlbuminuriaF7 , Serpine1
Alpha 1-Antitrypsin DeficiencySerpina1
Alpha-2-Macroglobulin DeficiencyA2m
Alzheimer DiseaseA2m , C1qb , C2 , C3 , C5ar1 , F2 , Mbl2 , Plau , Thbd
AmenorrheaCpb2
Amphetamine-Related DisordersCd55 , Cfh , Plat , Serpina5
Amyloid Neuropathies, FamilialF10 , F2
Amyloidosis, FamilialFga
Amyloidosis, Familial VisceralFga
Amyotrophic Lateral SclerosisC3 , C5ar1
Amyotrophic Lateral Sclerosis 1Masp2
AnaphylaxisC5ar1 , Kng2
Anemia, HemolyticA2m
Anemia, Iron-DeficiencyC1qa
Anemia, Refractory, with Excess of BlastsC3 , Cfb
Anemia, Sickle CellC3 , Cfb , F13a1 , F2 , F3
AneurysmMbl2
Angina PectorisCpb2 , Plau
Angina, StableF7
Angina, UnstableBdkrb1 , F7 , Plau , Serpinc1
AngioedemaF12 , Plat , Serping1
Angioedemas, HereditaryF12 , F2 , F7 , Kng2 , Serping1
AnoxiaPlat , Tfpi
Anti-Glomerular Basement Membrane DiseaseCfb
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisF3
Anti-Plasmin Deficiency, CongenitalSerpinf2
Antiphospholipid SyndromeApoh , Plat , Proc
Antithrombin III DeficiencySerpinc1
AnuriaPlau
Anxiety DisordersSerpina1
Aortic AneurysmSerpine1
Aortic Aneurysm, AbdominalSerpine1
Aortic InjuriesVwf
Aortic RemodelingSerpine1
AphasiaPlat
AppendicitisF2 , Plau
Arrhythmias, CardiacKng2
Arterial Occlusive DiseasesPlat , Plau
Arterial ThrombosisF7 , Mbl2 , Plat , Serpine1
ArteriolosclerosisC3
ArteriosclerosisApoh , F13a1 , F7 , Serpina1
ArteritisProc
Arthritis, ExperimentalA2m , C3 , C5 , Cd46 , Cd59 , Cfh , F2 , F2r , Klkb1 , Kng2 , Plau , Serpinc1 , Thbd
Arthritis, JuvenileC8b , Plaur , Pros1 , Tfpi , Thbd
Arthritis, RheumatoidA2m , Bdkrb2 , C3 , C4b , F2 , Plaur , Thbd
Arthus ReactionCfd
AsbestosisCfd , Serpina1
AspergillosisMbl1 , Mbl2
Aspergillosis, Allergic BronchopulmonaryMbl2
AsthenozoospermiaPlau
AsthmaBdkrb2 , C3 , C3ar1 , C5 , C5ar1 , F2 , F7 , Fga , Mbl2 , Plau , Proc , Serpina1 , Serpine1 , Thbd
AtherosclerosisF2 , Plat , Plau , Serpine1
Atrial FibrillationTfpi , Vwf
Atypical Hemolytic Uremic SyndromeC2 , C3 , C3ar1 , Cd46 , Cfb , Cfh , Cfi , Thbd
Autism Spectrum DisorderKlkb1
Autistic DisorderC4b , Plaur , Serpine1
Autoimmune DiseasesC1s , C4b , F8
Back PainPlat
BacteremiaCfh , Cpb2 , Mbl2 , Plat , Plaur , Serpinc1
Bacterial InfectionsMbl2
Basal Laminar DrusenCfh
Behcet SyndromeCfb , Cpb2 , F5 , Mbl2 , Proz , Serpine1 , Vwf
Bernard-Soulier SyndromeVwf
Beta-ThalassemiaCfb
Bile Duct DiseasesF3
Bipolar DisorderSerpina1 , Vwf
Birth WeightMbl2
Blood Coagulation DisordersF10 , F2 , F5 , Fga , Fgg , Plat , Proc , Pros1 , Proz , Serpinc1
Blood Coagulation Disorders, InheritedF7
Bone NeoplasmsPlau
Boutonneuse FeverC3 , Cfb
BradycardiaKng2
Brain EdemaC5 , F2 , F2r , Plat , Plau
Brain InfarctionCfh , Plat
Brain InjuriesC1qa , C3 , Cfb , F2 , Serpinc1 , Thbd
Brain IschemiaC3 , F2 , F2r , F5 , Fga , Plat , Plau , Proz , Serpine1
Branched-Chain Ketoacid Dehydrogenase Kinase DeficiencyKng2
Breast NeoplasmsCd46 , Cd55 , Cd59 , Cfb , F10 , F3 , F5 , F7 , Plau , Serpine1
BronchiectasisMbl2 , Serpina1
Bronchiolitis ObliteransMbl2
Bronchiolitis, ViralC3
BronchopneumoniaMbl2
Budd-Chiari SyndromeF5
BurnsA2m , Cpb2 , Fga , Plat , Serpina1 , Serping1 , Tfpi
C1q DeficiencyC1qa , C1qb , C1qc
C6 Deficiency, SubtotalC6
C9 DeficiencyC9
CalcinosisC6
Candidiasis, VulvovaginalMbl2
CarcinomaPlaur
Carcinoma, HepatocellularA2m , C3 , C9 , F2 , Serpina1
Carcinoma, Lewis LungC3
Carcinoma, Non-Small-Cell LungPlau , Thbd
Carcinoma, Pancreatic DuctalSerpina1
Carcinoma, Renal CellC4b , Cd46 , Plau , Vwf
Carcinoma, Squamous CellCfh , Plau
Carcinoma, Squamous Cell of Head and NeckSerpine1
Carcinoma, Transitional CellPlau
Cardiac Allograft VasculopathyF3
Cardiac FibrosisF3 , Serpine1
Cardiac TamponadePlat
CardiomegalyA2m , Plau
CardiomyopathiesBdkrb2
Cardiovascular DiseasesCfh , Fgb , Plaur , Vwf
Carnevale SyndromeMasp1
Carotid Artery DiseasesFgb , Plau , Vwf
Carotid Artery InjuriesPlat , Serpine1
Carotid Artery ThrombosisF3 , Klkb1 , Serpind1 , Thbd
Carotid StenosisF2
CD59 DeficiencyCd59
Celiac DiseaseF2
Central Nervous System Viral DiseasesPlat
Central Retinal Vein OcclusionProc
Central Serous ChorioretinopathySerpine1
Cerebral HemorrhageC3 , Cfh , F13a1 , F2 , F7 , Plat , Plau , Serpinc1
Cerebral InfarctionF2 , F5 , F7 , Plat , Plau , Plaur , Pros1 , Serpine1 , Serping1
Cerebral Small Vessel DiseasesFga , Fgg , Thbd
Cerebrovascular DisordersPlau
Cervical Intraepithelial NeoplasiaCd46
Chagas DiseaseF2
Chemotherapy-Induced Febrile NeutropeniaMbl2
CholestasisFga , Serpina1 , Serpine1
Choroidal NeovascularizationC5 , Cfb , Cfh , F7
Choroidal Neovascularization, ExperimentalSerpine1
Chronic Allograft DysfunctionC3 , F7
Chronic Allograft NephropathyPlau
Chronic RhinosinusitisMbl2
Clear-Cell Metastatic Renal Cell CarcinomaF2
CoccidioidomycosisMbl2
Colonic NeoplasmsA2m , Cd59 , F5 , Plau
Colorectal NeoplasmsF5 , F7
Common Variable ImmunodeficiencyCr2 , Mbl2
Communicable DiseasesMbl2
Complement Component 2 DeficiencyC2 , Cfb
Complement Component 3 Deficiency, Autosomal RecessiveC3
Complement Component 4, Partial Deficiency OfSerping1
Complement Component 5 DeficiencyC5
Complement Component 6 DeficiencyC6
Complement Component 7 DeficiencyC7
Complement Component 8 Deficiency, Type IC8a
Complement Component 8 Deficiency, Type IIC8b
Complement Component C1r/C1s DeficiencyC1r
Complement Component C1s DeficiencyC1s
Complement Factor B DeficiencyCfb
Complement Factor D DeficiencyCfd
Complement Factor H DeficiencyCfh
Complement Factor I DeficiencyCfi
Congenital Thrombotic Disease, due to Protein C DeficiencyProc
ConjunctivitisC3 , Cfb , Plg
ContusionsF2
Coronary Artery DiseaseF2 , F7 , Fgb , Serpina1 , Serpine1 , Serpinf2 , Thbd
Coronary DiseaseF12 , F13a1 , Plau , Serpinf2 , Thbd , Vwf
Coronary RestenosisF2r , Mbl2
Coronary ThrombosisPlat
Coronavirus InfectionsMbl2
CoughBdkrb2 , Kng2
Coumarin ResistanceF9
Coumarin SensitivityF9
Craniocerebral TraumaSerpinc1
Craniofacial AbnormalitiesMasp1
Crohn DiseaseF13a1 , F2 , Fga , Plaur , Thbd
Cystic FibrosisC5 , Mbl2
Cytomegalovirus InfectionsMbl2
DeathF12
Death, Sudden, CardiacKng2
Dermatitis, Allergic ContactF13a1 , Plat
Dermatitis, AtopicC3 , F2 , Mbl2
Dermatitis, ContactCd46
DermatomyositisC2 , C9 , Mbl2 , Thbd
Diabetes ComplicationsBdkrb1 , Bdkrb2
Diabetes MellitusApoh , Cpb2 , F3 , F7 , Serpine1 , Tfpi , Vwf
Diabetes Mellitus, ExperimentalBdkrb1 , Bdkrb2 , Cfd , F2 , F3 , F7 , Fga , Serpinc1 , Serpine1 , Thbd , Vwf
Diabetes Mellitus, Type 1Apoh , C3 , Cfb , F7 , Plat , Thbd
Diabetes Mellitus, Type 2Apoh , C3 , Cpb2 , F12 , F2 , F3 , F7 , F8 , F9 , Fga , Fgb , Fgg , Plat , Plaur , Serpinc1 , Serpine1 , Thbd
Diabetes, GestationalMbl2 , Plat
Diabetic AngiopathiesBdkrb1 , F3 , Plat , Serpine1
Diabetic CardiomyopathiesA2m
Diabetic FootMbl2 , Plat
Diabetic NephropathiesApoh , Bdkrb2 , C3 , C5 , Cpb2 , F2 , F3 , Klkb1 , Kng2 , Plat , Plau , Serpine1
Diabetic NeuropathiesBdkrb1 , F7 , Plat
Diabetic RetinopathyApoh , Bdkrb1 , Bdkrb2 , Cd59 , Cfb , Cfh , F13a1 , F7 , Serpine1 , Vwf
Diffuse PanbronchiolitisMbl2
Disease Models, AnimalF7 , Serpine1
Disseminated Intravascular CoagulationF13a1 , F2 , F3 , F7 , Fga , Plat , Proc , Serpinc1 , Serpine1 , Tfpi , Thbd
Drug EruptionsC4b , Kng2
Drug-Induced Liver InjuryApoh , C3 , Cpb2 , F13a1 , Fga , Plat , Plg , Serpina1 , Serping1 , Vwf
Drug-Related Side Effects and Adverse ReactionsFga , Thbd
DysarthriaF5
Dysfibrinogenemia, CongenitalFga , Fgb , Fgg
DyspneaF5
DysprothrombinemiaF2
EczemaPlau
EdemaBdkrb1 , Kng2
EHLERS-DANLOS SYNDROME, PERIODONTAL TYPE, 2C1s
Ehlers-Danlos Syndrome, Type VIIIC1r , C1s
EmbolismPlat
Embolism and ThrombosisF3 , Plat , Tfpi
Embolism, CholesterolPlat , Plau
EmphysemaCd46 , Serpina1
Empyema, PleuralPlau
Encephalomyelitis, Autoimmune, ExperimentalA2m , C3 , C6 , Cpb2
Endometrial NeoplasmsCd46 , Cd55 , Cd59
EndometriosisC1r , Cd55 , Cfd
EndotoxemiaF12 , F2 , F3 , F5 , F7 , F8 , Fga , Plat , Proc , Serpinc1 , Serpine1 , Serping1 , Tfpi , Thbd , Vwf
Endotoxin-Induced UveitisThbd
EnterocolitisKlkb1
Enterocolitis, NecrotizingPlaur
EosinophiliaBdkrb2 , Kng2
EpilepsyBdkrb1 , Bdkrb2
Epilepsy, Temporal LobeBdkrb1 , Bdkrb2
Erectile DysfunctionThbd
ErythemaC9
Erythema MultiformeMasp2
Erythema NodosumC3 , Cfb
ExanthemaC1qa
Experimental Autoimmune OrchitisSerpina1
Extrahepatic Portal Vein ObstructionF7
Extravasation of Diagnostic and Therapeutic MaterialsBdkrb2 , Kng2
Eye DiseasesF2
Facial DermatosesC9
Facial Nerve InjuriesCd59
Factor 8 Deficiency, AcquiredF8
Factor V DeficiencyF5 , Tfpi
Factor VII DeficiencyF10 , F7
Factor X DeficiencyF10 , F7
Factor XI DeficiencyF11
Factor XII DeficiencyF12
Factor XIII DeficiencyF13a1 , F13b
Factor Xiii, A Subunit, Deficiency OfF13a1
Factor XIII, B Subunit, Deficiency OfF13b
Familial Mediterranean FeverThbd
Fatty LiverF2 , F2r , Serpine1
Fatty Liver, AlcoholicSerpine1
Femur Head NecrosisA2m , F2 , F5 , Plat , Tfpi
Fetal DeathF5 , Tfpi
Fetal Growth RetardationApoh
Fetal ResorptionApoh
FeverA2m
FibrosarcomaSerpine1
FibrosisBdkrb1 , C5
Flaujeac Factor DeficiencyKng2
Fragile X SyndromeSerpina1
Frontotemporal DementiaMasp2
Fuchs' Endothelial DystrophyC3
Gastrointestinal HemorrhageVwf
Giant Cell ArteritisMbl2
GlaucomaCfh , Serpine1
Glaucoma, Primary Open AngleMbl2
GliomaBdkrb2 , C3 , F2 , Plau
GliosarcomaPlau
GlomerulonephritisBdkrb1 , C1qa , C3 , C6 , Cd59 , Cfd , Cfh , Cpb2 , F2 , Klkb1
Glomerulonephritis with Isolated C3 Deposits and Factor H DeficiencyCfh
Glomerulonephritis, IGAC1qa , C1qb , C2 , C3 , Cfb , Plau
Glomerulonephritis, MembranoproliferativeC1qa , Cfb , Cfh , Cfi , F5
Glomerulonephritis, MembranousA2m , C3 , C7 , Cfb , Cfh , Plg
GlomerulosclerosisSerpine1
Glomerulosclerosis, Focal SegmentalBdkrb1 , Cfb , Serpine1 , Vwf
Graft Occlusion, VascularPlau
Graft vs Host DiseaseF3 , Tfpi
Granulomatosis with PolyangiitisThbd
Graves DiseaseC4b , Serpine1
Graves OphthalmopathySerpine1
Hashimoto DiseaseC1s , Mbl2
Hearing Loss, Noise-InducedCfi , Proc
Hearing Loss, SensorineuralF2 , F5 , Mbl2
Hearing Loss, SuddenSerpine1
Heart DiseasesA2m
Heart FailureCfd , Plat , Serpine1 , Vwf
Heart Rupture, Post-InfarctionPlau
Heart Valve DiseasesC6
Heat StrokeProc , Serpinc1 , Thbd
Hematologic DiseasesSerpine1
Hematoma, Epidural, SpinalPlat
Hematoma, SubduralPlat
Hematoma, Subdural, AcuteF7
HematuriaC3 , F7 , Plau
Hemoglobinuria, ParoxysmalC3 , C5
Hemolytic-Uremic SyndromeCd46 , Cfh , Mbl2 , Plat , Thbd
Hemophilia AC3 , C5 , Cfb , F2 , F8 , F9 , Plat , Tfpi , Vwf
Hemophilia BF2 , F9
HemorrhageBdkrb2 , F10 , F13a1 , F2 , F3 , F7 , F8 , Plat , Plau , Serpina1 , Serpine1 , Serpinf2
Hemorrhagic DisordersF7
Heparin Cofactor II DeficiencySerpind1
HepatitisF2r
Hepatitis BPlau , Plaur
Hepatitis C, ChronicPlau
Hepatitis, AutoimmuneC1s , F2
Hepatitis, ChronicPlat
Hepatitis, Viral, HumanF2
Hepatolenticular DegenerationA2m
Hereditary Angioedema Type IIIF12
Hereditary Angioedema Types I and IIC1s , Serping1
Herpes SimplexC3 , Mbl1 , Mbl2
Herpesviridae InfectionsC3 , Cd46
Hirschsprung Disease 1Plau
HIV InfectionsC3 , Mbl2 , Plaur , Serpina1
Huntington DiseaseF2
Hyaline Membrane DiseaseSerpine1
HyperaldosteronismSerpina1
HyperalgesiaBdkrb1 , Bdkrb2 , C3 , F2 , F2r , Kng2 , Thbd
HyperbilirubinemiaF12 , F7
HypercholesterolemiaCpb2 , Serpinf2
HyperemiaBdkrb2 , Kng2
Hypereosinophilic SyndromeF5
HyperesthesiaKng2
HyperglycemiaF2 , F7
HyperhomocysteinemiaF10 , F12 , F2 , F8
Hyperlipidemia, Familial CombinedThbd
HyperlipidemiasF3 , F7 , Plau , Serpinc1 , Serpinf2 , Tfpi
HyperlipoproteinemiasApoh , Serpinf2
HyperoxiaPlau
HypersensitivityKng2
HypertensionBdkrb1 , Bdkrb2 , C3 , F11 , F12 , F2r , F3 , F7 , Klkb1 , Kng2 , Plat , Plg , Proc , Serpina1 , Serpine1 , Serpinf2 , Thbd , Vwf
Hypertension, PortalBdkrb2
Hypertension, Pregnancy-InducedTfpi
Hypertension, PulmonaryBdkrb2 , F5 , Serpina1 , Serpine1 , Thbd , Vwf
HyperthyroidismSerpine1
HypertriglyceridemiaF7 , Serpinf2
HypertrophyF2
Hypertrophy, Left VentricularBdkrb1 , Bdkrb2 , Plau
Hypertrophy, Right VentricularPlat
HypoalbuminemiaA2m
Hypodysfibrinogenemia, CongenitalFga , Fgg
HypoglycemiaSerpina1
HypoprothrombinemiasF2 , F7
HypotensionBdkrb2 , Kng2 , Plat , Plau
HypothyroidismF7 , Thbd
Hypoxia-Ischemia, BrainPlat , Plau , Serpine1
Idiopathic Pulmonary FibrosisF3 , Plau , Tfpi , Thbd
Immune Complex DiseasesC1qa , Masp2
Immunologic Deficiency SyndromesC1qb , C3 , C5 , C8a , C8b , C9 , Cfd , Cfh
Infarction, Middle Cerebral ArteryC3 , F11 , F12 , Plat , Plau , Proc , Serpine1
InfectionMbl2 , Serpind1
Infertility, FemaleProc
InflammationA2m , Bdkrb1 , Bdkrb2 , F2r , F3 , Fgg , Masp2 , Plau , Plaur , Serpinc1 , Thbd
Inflammatory Bowel Disease 11F2 , Masp2 , Thbd
Inflammatory Bowel DiseasesKlkb1
Influenza, HumanC3 , Serping1
Insulin ResistanceBdkrb1 , C1r , C3 , Cpb2 , F7 , Serpina1 , Serpine1 , Thbd , Vwf
Intestinal IschemiaCfh
Intestinal Reperfusion InjuryF7 , Proc , Serpinc1 , Serpine1 , Vwf
Intracranial AneurysmPlau
Intracranial Embolism and ThrombosisPlat , Plau
Intracranial Hemorrhage, TraumaticF7
Intracranial HemorrhagesF7 , Plat , Plau , Serping1
Intracranial ThrombosisPlat , Serpinc1 , Vwf
Invasive Pulmonary AspergillosisMbl2
IschemiaPlau , Thbd
Ischemic Attack, TransientC3 , F12 , Plat , Plau , Serpine1 , Tfpi , Vwf
Jaundice, ObstructiveCfh
Jaw CystsPlau
KeloidFgg
KeratoconusFga
Kidney CalculiF2
Kidney DiseasesCd46 , F7 , Fga
Kidney Failure, ChronicBdkrb1 , C6 , Cfb , F2 , F5 , Fgb , Mbl2 , Plau , Plaur , Serpine1 , Thbd , Vwf
Kidney NeoplasmsPlau
Kidney Reperfusion InjuryBdkrb1 , C3 , Cfb , Cfh , F3 , Fga , Fgb , Fgg , Serpinc1 , Tfpi , Vwf
LeishmaniasisC3
Leishmaniasis, VisceralMbl2
Leprosy, LepromatousC3 , Cfb , Mbl2
LeptospirosisMbl2
LeukemiaTfpi
Leukemia, Lymphocytic, Chronic, B-CellThbd
Leukemia, Myeloid, AcuteBdkrb1 , Bdkrb2 , F3
Leukemia, Promyelocytic, AcuteF3 , Plat , Thbd
LeukocytosisKng2
LeukopeniaPlat
Liver CirrhosisA2m , C1qb , F2 , F2r , F3 , F5 , Klkb1 , Plau , Plaur , Serpina1 , Serping1 , Tfpi
Liver Cirrhosis, AlcoholicPlau
Liver Cirrhosis, ExperimentalA2m , C1qa , C1qb , C1qc , C5ar1 , C7 , C8g , Cfd , F2r , F5 , Fgg , Kng2 , Plat , Plau , Plg , Pros1 , Serpinc1 , Thbd , Vwf
Liver DiseasesMbl2 , Serpina1 , Thbd
Liver Diseases, AlcoholicC6 , Cd59 , Plaur
Liver FailureF2
Liver Failure, AcuteFga , Serpinc1 , Thbd
Liver InjuryFgg , Tfpi
Liver NeoplasmsSerpine1
Liver Neoplasms, ExperimentalF12 , Serpina1
Liver Reperfusion InjuryC3 , Cfh , F3 , Fga , Proc , Serpinc1 , Serpine1 , Serping1 , Tfpi
Low Back PainPlat
Lung DiseasesA2m , Bdkrb2 , C3 , C3ar1 , C5 , C5ar1 , Serpina1 , Serpine1
Lung Diseases, FungalC5
Lung Diseases, InterstitialSerpine1
Lung Diseases, ObstructiveA2m
Lung InjuryPlau , Plaur
Lung NeoplasmsA2m , Mbl2 , Plau , Serpina1
Lung Reperfusion InjuryProc , Serpine1
Lupus Erythematosus, SystemicC1qa , C2 , C3 , C3ar1 , C4b , C5ar1 , Cd46 , Cfb , Cfh , Cr2 , F2 , Klkb1 , Mbl2 , Tfpi , Thbd
Lupus NephritisC3 , Cfb , Cfh , Klkb1 , Serping1
Lyme DiseasePlaur
Macular DegenerationC2 , C3 , C9 , Cfb , Cfh , Cfi , Serpine1 , Serping1
Macular Degeneration, Age-Related, 1C2 , Cfb
Macular Degeneration, Age-Related, 13Cfi
Macular Degeneration, Age-Related, 14C2 , Cfb
Macular Degeneration, Age-Related, 15C9
Macular Degeneration, Age-Related, 4Cfh
Macular Degeneration, Age-Related, 7C3 , Cfb
Macular Degeneration, Age-Related, 9C3
Macular EdemaApoh
Malaria, FalciparumMbl2
Malpuech Facial Clefting SyndromeMasp1
Mammary Neoplasms, AnimalKng2
Mammary Neoplasms, ExperimentalPlau
Mannose-Binding Protein DeficiencyMbl2
MASP2 DeficiencyMasp2
MastitisC3
MeaslesCd46
MelanomaC3
MelioidosisPlaur
MeningitisC8a , C8b , Plau , Plaur
Meningitis, BacterialCd46
Meningitis, MeningococcalC9 , Cd46
Meningitis, PneumococcalSerping1
Meningococcal InfectionsC3 , Cfb , Cfd , Cfh , Cpb2
MeningoencephalitisPlat
Mesangial Proliferative GlomerulonephritisVwf
Mesenteric IschemiaF2 , F5
Mesenteric Vascular OcclusionSerpind1
Mesothelioma, MalignantC9 , F9
Metabolic Syndrome XC3 , F3 , Plat , Serpine1 , Thbd , Vwf
Microvascular AnginaBdkrb1 , Bdkrb2
Mitral Valve ProlapsePlau
Mouth NeoplasmsFga , Plau
Mucocutaneous Lymph Node SyndromeMbl1 , Mbl2
Multifocal ChoroiditisCfb , Cfh
Multiple MyelomaCd46 , Fgg
Multiple Organ FailureC5ar1 , Cpb2 , Plat , Serpinc1 , Serpine1 , Thbd
Multiple SclerosisCd46 , Cfh
Multiple TraumaSerpine1
Muscular AtrophySerpine1
Myasthenia GravisCfb
Myasthenia Gravis, Autoimmune, ExperimentalC3 , C6 , Cfb
MycosesMbl2
Myeloproliferative DisordersF3
Myocardial InfarctionApoh , Bdkrb1 , Bdkrb2 , C3 , C7 , C8a , C8b , Cd59 , F10 , F12 , F13a1 , F2 , F3 , F5 , F7 , Fgb , Plat , Plau , Plaur , Proc , Serpine1 , Tfpi , Thbd , Vwf
Myocardial IschemiaC1qb , F3 , F5 , Serpina1
Myocardial Reperfusion InjuryC3 , C5 , Kng2 , Mbl1 , Mbl2 , Serpine1 , Serping1
Nasal PolypsMbl2 , Plaur
Neisseriaceae InfectionsC8a , C8b , Cfd
NeointimaF3 , Serpine1 , Tfpi
Neoplasm InvasivenessPlau , Plaur
Neoplasm MetastasisF2 , Plau , Plaur , Serpina1 , Serpinc1
Neoplasm Recurrence, LocalPlau
NeoplasmsPlaur , Tfpi
Neoplasms, ExperimentalF2r
Neoplasms, Glandular and EpithelialF7
Neovascularization, PathologicSerpine1
NephritisBdkrb1 , Plau
NephrolithiasisF2
NephrosisCd59 , Cfh , F2
Nephrotic SyndromeA2m , Cpb2 , F3 , Serpinc1 , Serpine1 , Tfpi
Nerve DegenerationF2 , Plat
Nervous System DiseasesSerpine1
Neuritis, Autoimmune, ExperimentalCd59
NeuroblastomaCd55
Neurodegenerative DiseasesSerpina1
Neuropathy, PainfulThbd
Neurotoxicity SyndromesPlat
NeutropeniaC5 , C5ar1
Non-alcoholic Fatty Liver DiseaseF2
Nonproliferative Diabetic RetinopathyA2m
Noonan SyndromeF11
ObesityBdkrb1 , C3 , C5ar1 , Cfd , Cpb2 , F2 , F7 , Fgg , Mbl1 , Mbl2 , Plat , Plaur , Serpine1 , Thbd , Vwf
Ocular HypertensionC1qb , C3
Oculopalatoskeletal syndromeMasp1
Opioid-Related DisordersC9
Optic Nerve InjuriesC3 , Plau
Optic Neuropathy, IschemicF5
Oral Squamous Cell CarcinomaPlau , Serpine1
OsteoarthritisSerpina1
Osteoarthritis, KneeF2
OsteonecrosisTfpi
OsteoporosisFga , Fgb
Otitis MediaC2 , C3 , Cfb , Mbl2
Otitis Media with EffusionC3
Ovarian CystsC1qb , Cfd
Ovarian Hyperstimulation SyndromeF3 , Tfpi
Ovarian NeoplasmsCd46 , Cd59 , F2 , F7 , Serpinc1
Ovary Reperfusion InjuryF3
Oxygen-Induced RetinopathySerpine1
PainBdkrb1 , Bdkrb2 , Kng2
Pancreatic AdenocarcinomaPlat
Pancreatic NeoplasmsPlau , Serpina1
PancreatitisBdkrb2 , Fga , Fgb , Fgg , Serpina1 , Serping1
Pancreatitis, AcuteF7
Pancreatitis, Acute NecrotizingC5 , C5ar1 , Cd46 , Cd59 , Serpine1 , Serpinf2 , Serping1
Pancreatitis, Experimental, Acute Proc , Serpinc1 , Vwf
Panniculitis, Nodular NonsuppurativeSerpina1
PanuveitisCfh
ParacoccidioidomycosisCfb
Paraparesis, Tropical SpasticC3
ParatuberculosisC1r , C3 , F2
ParesisPlat
Parkinson DiseaseA2m , Fgb
Pediatric Crohn's DiseaseF2
Pemphigoid, BullousCfb , F2
PemphigusC3 , Mbl2
Pericardial EffusionPlat
Peripheral Arterial DiseaseSerpine1
Peripheral Nerve InjuriesPlau
Peripheral Nervous System DiseasesMbl2
Peripheral Vascular DiseasesApoh , Mbl2
Peritoneal AdhesionsSerpine1
Peritoneal FibrosisF10 , F3 , F5 , Serpinc1
PeritonitisA2m , C5 , Plat , Plau , Plaur
Pigmentation DisordersMasp1
Plasminogen Activator Inhibitor-1 DeficiencySerpine1
Plasminogen Deficiency, Type IPlg
PleurisyBdkrb1 , Bdkrb2 , C3
PneumoniaBdkrb2 , C3 , C3ar1 , C5 , Cfd , Mbl2 , Serpine1
Pneumonia, BacterialC3 , C3ar1 , C5 , F2 , Mbl2 , Serpine1
Pneumonia, PneumococcalC3 , C5 , Masp2 , Mbl2
Pneumonia, PneumocystisC3
Polycystic Kidney DiseasesC9 , Cfb
Polycystic Kidney, Autosomal DominantC9 , Cfb , Serping1
Polycystic Kidney, Autosomal RecessiveC3
PolycythemiaSerpine1
Polymyalgia RheumaticaMbl2
PolyneuropathiesSerpine1
Polypoidal Choroidal VasculopathyC2 , Cfb , Cfh
Postoperative ComplicationsF7
Pre-EclampsiaC3 , Cd46 , F2 , F2r , F3 , F5 , Plaur , Proc , Serpina1 , Serpine1 , Serpinf2 , Tfpi
Precursor B-Cell Lymphoblastic Leukemia-LymphomaF13a1 , F3 , Tfpi
Precursor Cell Lymphoblastic Leukemia-LymphomaCd46 , Cfb , F3 , Fga
Pregnancy in DiabeticsApoh
Prekallikrein DeficiencyKlkb1
Premature BirthMbl2
Preterm Premature Rupture of the MembranesF3 , Tfpi
Primary MyelofibrosisBdkrb1 , Bdkrb2
Prion DiseasesPlau , Plaur
Proliferative Diabetic RetinopathySerpine1
Prostatic NeoplasmsC3ar1 , C5 , Cd55 , F2 , F5 , Plau , Plaur , Serpine1
Protein C DeficiencyProc
Protein C Deficiency, AcquiredSerpine1
Protein S DeficiencyPros1 , Tfpi
ProteinuriaC6 , Cd55 , Cfh , F7 , Serpina1
Prothrombin Deficiency, CongenitalF2
Pseudomonas InfectionsMbl2
PsoriasisC2 , Cfb , Cfh , Cfi , Mbl2
Pulmonary AspergillosisMbl2
Pulmonary Disease, Chronic ObstructiveBdkrb2 , C3 , C5 , C5ar1 , F2 , Mbl2 , Plau , Plaur , Serpina1 , Serpine1
Pulmonary EmbolismF13a1 , F2 , F5 , Fga , Fgb , Fgg , Klkb1 , Plat , Plau , Proc , Pros1 , Serpinf2 , Thbd
Pulmonary EmphysemaFga , Serpina1
Pulmonary EosinophiliaC3
Pulmonary FibrosisBdkrb1 , Cfd , F2 , F5 , Mbl2 , Plau , Serpina1 , Serpine1 , Tfpi , Vwf
Purpura FulminansProc
Purpura, Schoenlein-HenochC3 , Kng2 , Plat , Plau
Purpura, ThrombocytopenicVwf
Purpura, Thrombocytopenic, IdiopathicPlat
Purpura, Thrombotic ThrombocytopenicF3 , Proc , Tfpi , Thbd
PyelonephritisCfb
Quebec Platelet DisorderPlau
Radiation PneumonitisC3 , C4bpa
Renal FibrosisBdkrb1 , Cpb2 , Plau , Serpine1
Renal Insufficiency, ChronicCpb2
Reperfusion InjuryC3 , C3ar1 , C5 , C5ar1 , Cd55 , Cd59 , Cfh , F2 , Mbl1 , Mbl2 , Plat , Plau , Plaur , Serping1 , Thbd
Respiratory Distress Syndrome, AdultC3 , C5 , F3 , Mbl2 , Plau , Pros1 , Serpinc1 , Serpine1 , Thbd
Respiratory HypersensitivityMbl2 , Serpine1
Respiratory InsufficiencyMbl2 , Plat
Respiratory Tract InfectionsMbl2
Retinal Artery OcclusionF5
Retinal DegenerationC3 , Cfb , Cfh
Retinal DrusenCfh
Retinal Vein OcclusionF2 , F5 , Serpine1
Retinopathy of PrematuritySerpine1
Retrograde DegenerationC1qb
RhinitisBdkrb1 , Bdkrb2 , C3 , C3ar1 , C5ar1 , Mbl2 , Plau , Serpine1
Rhinitis, AllergicF2 , Serpine1
Rhinitis, Allergic, SeasonalFga
RhinosinusitisC3 , Serpine1
Sagittal Sinus ThrombosisF5 , Plau , Pros1
SarcoidosisCfh
Sarcoidosis, PulmonaryC3
SchizophreniaSerpind1 , Vwf
Sciatic NeuropathyBdkrb1 , Bdkrb2 , C3 , Plat , Plau , Serpine1
Scleroderma, SystemicC3 , Cfb , F2 , Serpinf2 , Vwf
SeizuresC7 , Plau
SepsisA2m , C3 , C5 , C5ar1 , C6 , Cfb , Cfh , Cpb2 , F11 , F2 , F3 , F5 , F7 , F9 , Fga , Klkb1 , Plat , Plau , Plaur , Proc , Serpine1 , Tfpi , Thbd
Septic PeritonitisF5
Shock, CardiogenicPlat
Shock, HemorrhagicCfh , F2 , F8 , Vwf
Shock, SepticA2m , C5ar1 , Mbl2 , Plaur , Proc , Serpinc1 , Serpine1 , Serping1 , Tfpi
Shock, TraumaticSerping1
SilicosisC3
Sinus Thrombosis, IntracranialF2
SinusitisCfb , Plau , Plaur
Sjogren's SyndromeC3
Skin Diseases, VascularF2
Sleep Apnea SyndromesSerpine1
Sleep Apnea, ObstructiveSerpine1
Smith-Magenis SyndromeApoh
Smoke Inhalation InjuryF7 , Mbl2
Snake BitesF3
Spinal Cord CompressionPlat
Spinal Cord InjuriesC1qb , F2 , Plau , Plaur , Serpinc1 , Thbd
Spinal Cord Reperfusion InjuryProc
SplenomegalyBdkrb1
Spondylitis, AnkylosingThbd
Status EpilepticusPlat , Plau , Plaur
Stomach NeoplasmsF2r , Fgg , Plau , Serpina1 , Serpine1 , Thbd
Stomach UlcerF13a1
StrokeApoh , Cfh , F12 , F13a1 , F2 , F5 , F8 , Fgb , Fgg , Kng2 , Plat , Plau , Proz , Serpine1 , Thbd , Vwf
Strongylida InfectionsPlau
Subarachnoid HemorrhageC3
Systemic Inflammatory Response SyndromeCfh , F3 , Plaur , Thbd
TachycardiaKng2
Thiamine DeficiencySerpina1
Thrombocythemia, EssentialBdkrb1 , Bdkrb2 , Vwf
ThrombocytopeniaF7 , Fga , Mbl2
ThrombocytosisCpb2
ThromboembolismCpb2 , F12 , F2 , F3 , F5 , F7 , F8 , Plat , Plau , Proc , Pros1 , Proz , Thbd
ThrombophiliaC3 , C5 , Cd46 , F13a1 , F2 , F3 , F5 , F8 , Fga , Plg , Proc , Serpina10 , Serpind1 , Thbd
Thrombophilia due to Activated Protein C ResistanceF5
Thrombophilia due to Protein S Deficiency, Autosomal DominantPros1
Thrombophilia due to Thrombomodulin DefectThbd
Thrombophilia, Familial, due to Decreased Release of Tissue Plasminogen ActivatorPlat
Thrombophilia, HereditaryF5
Thrombophilia, Hereditary, Due To Protein C Deficiency, Autosomal DominantProc
Thrombophilia, Hereditary, due to Protein C Deficiency, Autosomal RecessiveProc
Thrombophilia, Hereditary, Due To Protein S Deficiency, Autosomal RecessivePros1
Thrombophilia, X-Linked, Due To Factor Ix DefectF9
ThrombophlebitisPros1
ThrombosisApoh , Bdkrb2 , C5ar1 , F10 , F11 , F2 , F2r , F3 , F5 , F9 , Fga , Fgb , Klkb1 , Plat , Plau , Proc , Pros1 , Serpinc1 , Serpine1 , Thbd , Vwf
Thrombotic MicroangiopathiesC3 , Cfh , Cfi , Cpb2 , F3 , Fgg , Vwf
Thrombotic Thrombocytopenic Purpura, AcquiredVwf
Thyroid cancer, papillaryPlau
Thyroiditis, AutoimmuneMbl2
Transplant RejectionPlat , Plau
TrypanosomiasisA2m
Tuberculosis, PulmonaryC3 , Mbl2 , Plaur
Ureteral ObstructionSerpine1
Urinary Bladder NeoplasmsF2 , Plau , Serpine1
Urinary Bladder, OveractiveBdkrb1
Urinary CalculiF2
UrolithiasisPlau
UrticariaF12 , F2
Uterine Cervical NeoplasmsCd46 , Cd55
Uterine HemorrhageF13a1
Uveal MelanomaSerpine1
Uveitis, AnteriorC2 , C3 , Cd59 , Cfb , Cfh
Uveitis, PosteriorCfh
Uveoretinitis, Autoimmune, ExperimentalC3 , Cfb
Vaginosis, BacterialMbl2
Varicose UlcerMbl2
Vascular DepressionSerpine1
Vascular DiseasesPros1
Vascular RemodelingSerpine1
Vascular System InjuriesBdkrb1 , Bdkrb2
VasculitisSerpina1
Vaso-occlusive CrisisMbl2
Vasospasm, IntracranialPlat
Venous ThromboembolismCd46 , F2 , F5 , Fga , Kng2 , Plat , Proc , Pros1 , Serpinc1 , Serpind1 , Serpine1 , Tfpi , Vwf
Venous ThrombosisF11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , Fga , Plat , Plau , Plg , Proc , Pros1 , Serpina10 , Serpina5 , Serpinc1 , Serpine1 , Tfpi
Ventilator-Induced Lung InjurySerpine1
Ventricular Dysfunction, LeftF2 , Plat
Ventricular FibrillationF2 , Plau
Viral MyocarditisF3 , Plau
Virus DiseasesCd46
VitiligoC3 , Mbl2
Vitreoretinopathy, ProliferativeKng2
von Willebrand Disease, Type 1Plat , Vwf
von Willebrand Disease, Type 2Vwf
von Willebrand Disease, Type 3Vwf
von Willebrand DiseasesF3 , Vwf
Warfarin SensitivityF9
Wet Macular DegenerationC3 , Cfi
Wounds and InjuriesPlat
Wounds, PenetratingC3 , Serpine1
Pathway Annotations Associated with Genes in the coagulation cascade pathway
Pathway TermsGene Symbols
acenocoumarol pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
alteplase pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
Alzheimer disease pathwayA2m
aminocaproic acid pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
anistreplase pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
aprotinin pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
argatroban pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
B cell receptor signaling pathwayCr2
bivalirudin pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
calcium/calcium-mediated signaling pathwayBdkrb1 , Bdkrb2 , F2r
cell-extracellular matrix signaling pathwayVwf
classical complement pathwayC3
coagulation cascade pathwayA2m , Apoh , Bdkrb1 , Bdkrb2 , C1qa , C1qb , C1qc , C1r , C1s , C2 , C3 , C3ar1 , C4b , C4bpa , C4bpb , C5 , C5ar1 , C6 , C7 , C8a , C8b , C8g , C9 , Cd46 , Cd55 , Cd59 , Cfb , Cfd , Cfh , Cfi , Cpb2 , Cr1l , Cr2 , F10 , F11 , F12 , F13a1 , F13b , F2 , F2r , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Kng2 , Kng2l1 , Masp1 , Masp2 , Mbl1 , Mbl2 , Plat , Plau , Plaur , Plg , Proc , Pros1 , Proz , Serpina1 , Serpina10 , Serpina5 , Serpinc1 , Serpind1 , Serpine1 , Serpinf2 , Serping1 , Tfpi , Thbd , Vwf
complement system pathwayA2m , Bdkrb1 , Bdkrb2 , C1qa , C1qb , C1qc , C1r , C1s , C2 , C3 , C3ar1 , C4b , C4bpa , C4bpb , C5 , C5ar1 , C6 , C7 , C8a , C8b , C8g , C9 , Cd46 , Cd55 , Cd59 , Cfb , Cfd , Cfh , Cfi , Cpb2 , Cr1l , Cr2 , F10 , F12 , F13a1 , F13b , F2 , F2r , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Kng2 , Kng2l1 , Masp1 , Masp2 , Mbl1 , Mbl2 , Plat , Plau , Plaur , Plg , Proc , Pros1 , Serpina1 , Serpina5 , Serpinc1 , Serpind1 , Serpine1 , Serpinf2 , Serping1 , Tfpi , Thbd , Vwf
dicoumarol pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
endocytosis pathwayF2r
enoxaparin pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg , Serpinc1
Entamoeba histolyca infection pathwayC8a , C8b , C8g , C9
ephrin - ephrin receptor bidirectional signaling axisFga , Fgb , Fgg
fibrinolysis pathwayCpb2 , Fga , Fgb , Fgg , Plat , Plau , Plg , Serpina5 , Serpine1 , Serpinf2
fibroblast growth factor signaling pathwayPlau , Plaur
fondaparinux pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg , Serpinc1
forkhead class A signaling pathwayC4bpb , F2 , Serpina1
G protein mediated signaling pathwayF2r
G protein mediated signaling pathway via Galphai familyBdkrb1 , Bdkrb2
G protein mediated signaling pathway via Galphaq familyBdkrb1 , Bdkrb2
glypican signaling pathwaySerpinc1
heparin pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg , Serpinc1
hypoxia inducible factor pathwaySerpine1
immune response pathwayA2m
inflammatory response pathwayA2m
influenza A virus infection pathwayPlg
interleukin-6 signaling pathwayA2m , Fgg
kallikrein-kinin cascade pathwayA2m , Bdkrb1 , Bdkrb2 , F12 , Klkb1 , Kng2 , Serping1
kinin signaling pathwayBdkrb1 , Bdkrb2 , Kng2
lectin complement pathwayMbl2
Leishmania infection pathwayC3
measles infection pathwayCd46
Mycobacterium tuberculosis infection pathwayC3
myocarditis pathwayCd55
oxygen homeostasis pathwaySerpine1
p53 signaling pathwaySerpine1
phagocytosis pathwayC1r , C3 , Mbl1 , Mbl2
phenindione pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
platelet aggregation pathwayVwf
prion diseases pathwayC1qa , C1qb , C1qc , C5 , C6 , C7 , C8a , C8b , C8g , C9
protease mediated signaling via protease-activated receptor 1F2 , F2r , Proc
protease mediated signaling via protease-activated receptor 2F10
protease mediated signaling via protease-activated receptor 3F2
protease mediated signaling via protease-activated receptor 4F2
protein C anticoagulant pathwayF2 , F5 , Proc , Pros1 , Thbd
reteplase pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
Staphylococcus aureus infection pathwayC1qa , C1qb , C1qc , C1r , C1s , C2 , C3 , C3ar1 , C4b , C5 , C5ar1 , Cfb , Cfd , Cfh , Cfi , Fgg , Masp1 , Masp2 , Mbl1 , Mbl2 , Plg
syndecan signaling pathwayF2 , Kng2 , Plg , Tfpi
systemic lupus erythematosus pathwayC1qa , C1qb , C1qc , C1r , C1s , C2 , C3 , C4b , C5 , C6 , C7 , C8a , C8b , C8g , C9
tranexamic acid pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
transforming growth factor-beta Smad dependent signaling pathwayA2m
Trypanosoma cruzi infection pathwayBdkrb2 , C1qa , C1qb , C1qc , C3 , Serpine1
vitamin K metabolic pathwayF2
warfarin pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
Phenotype Annotations Associated with Genes in the coagulation cascade pathway

References Associated with the coagulation cascade pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: