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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of PRKCI mRNA | CTD | PMID:15212814 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PRKCI mRNA | CTD | PMID:21724226 | 4-vinylcyclohexene dioxide | affects expression | ISO | RGD:1331958 | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of PRKCI mRNA | CTD | PMID:20829426 | 5-fluorouracil | multiple interactions | ISO | RGD:732937 | 6480464 | TP53 protein affects the reaction [Fluorouracil results in decreased expression of PRKCI mRNA] | CTD | PMID:15016801 | all-trans-retinoic acid | affects expression | ISO | RGD:732937 | 6480464 | Tretinoin affects the expression of PRKCI mRNA | CTD | PMID:15498508 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PRKCI mRNA | CTD | PMID:16483693 | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of PRKCI mRNA | CTD | PMID:16101753 | bisphenol A | increases expression | ISO | RGD:1331958 | 6480464 | bisphenol A results in increased expression of PRKCI protein | CTD | PMID:23545179 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of PRKCI mRNA | CTD | PMID:19167457 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of PRKCI mRNA | CTD | PMID:19368821 | cisplatin | affects response to substance | ISO | RGD:732937 | 6480464 | PRKCI protein affects the susceptibility to Cisplatin | CTD | PMID:16217747 | cobalt dichloride | increases expression | ISO | RGD:732937 | 6480464 | cobaltous chloride results in increased expression of PRKCI mRNA | CTD | PMID:19376846 | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of PRKCI mRNA | CTD | PMID:22465980 | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of PRKCI mRNA | CTD | PMID:22465980 | copper(2+) sulfate | increases expression | ISO | RGD:732937 | 6480464 | Copper Sulfate results in increased expression of PRKCI mRNA | CTD | PMID:19549813 | diazinon | affects expression | EXP | | 6480464 | Diazinon affects the expression of PRKCI mRNA | CTD | PMID:17452286 | doxorubicin | affects response to substance | ISO | RGD:732937 | 6480464 | PRKCI protein affects the susceptibility to Doxorubicin | CTD | PMID:16217747 | elemental selenium | multiple interactions | ISO | RGD:732937 | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of PRKCI mRNA | CTD | PMID:19244175 | elemental selenium | decreases expression | ISO | RGD:732937 | 6480464 | Selenium results in decreased expression of PRKCI mRNA | CTD | PMID:19244175 | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of PRKCI mRNA | CTD | PMID:20655511 | ethanol | multiple interactions | EXP | | 6480464 | N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of PRKCI mRNA] | CTD | PMID:20655511 | indomethacin | decreases expression | ISO | RGD:732937 | 6480464 | Indomethacin results in decreased expression of PRKCI mRNA | CTD | PMID:16984733 | lead diacetate | decreases expression | EXP | | 6480464 | lead acetate results in decreased expression of PRKCI protein | CTD | PMID:16547843 | lead(0) | decreases expression | EXP | | 6480464 | Lead results in decreased expression of PRKCI protein | CTD | PMID:16547843 | phlorizin | decreases expression | ISO | RGD:1331958 | 6480464 | Phlorhizin results in decreased expression of PRKCI mRNA | CTD | PMID:22538082 | phorbol 13-acetate 12-myristate | increases localization | ISO | RGD:732937 | 6480464 | Tetradecanoylphorbol Acetate results in increased localization of PRKCI protein | CTD | PMID:21295103 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | RGD:732937 | 6480464 | wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of PRKCI protein] | CTD | PMID:21295103 | pirinixic acid | increases expression | ISO | RGD:1331958 | 6480464 | pirinixic acid results in increased expression of PRKCI mRNA | CTD | PMID:18301758 | quercetin | decreases expression | ISO | RGD:732937 | 6480464 | Quercetin results in decreased expression of PRKCI mRNA | CTD | PMID:21632981 | resveratrol | decreases expression | ISO | RGD:732937 | 6480464 | resveratrol results in decreased expression of PRKCI protein | CTD | PMID:18089832 | Ro 31-8220 | decreases activity | ISO | RGD:1331958 | 6480464 | Ro 31-8220 results in decreased activity of PRKCI protein | CTD | PMID:14511371 | selenium atom | multiple interactions | ISO | RGD:732937 | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of PRKCI mRNA | CTD | PMID:19244175 | selenium atom | decreases expression | ISO | RGD:732937 | 6480464 | Selenium results in decreased expression of PRKCI mRNA | CTD | PMID:19244175 | tamibarotene | decreases expression | ISO | RGD:732937 | 6480464 | Am 80 results in decreased expression of PRKCI mRNA; more ... | CTD | PMID:15498508 | trans-resveratrol | decreases expression | ISO | RGD:732937 | 6480464 | resveratrol results in decreased expression of PRKCI protein | CTD | PMID:18089832 | vanadium atom | affects localization | ISO | RGD:1331958 | 6480464 | Vanadium affects the localization of PRKCI protein | CTD | PMID:14971662 | vanadium atom | increases expression | ISO | RGD:732937 | 6480464 | Vanadium results in increased expression of PRKCI mRNA | CTD | PMID:19000753 | vanadium atom | multiple interactions | ISO | RGD:1331958 | 6480464 | PRKCI protein mutant form inhibits the reaction [Vanadium results in increased phosphorylation of and results in increased activity of AKT1 protein] | CTD | PMID:14971662 | vanadium(0) | affects localization | ISO | RGD:1331958 | 6480464 | Vanadium affects the localization of PRKCI protein | CTD | PMID:14971662 | vanadium(0) | increases expression | ISO | RGD:732937 | 6480464 | Vanadium results in increased expression of PRKCI mRNA | CTD | PMID:19000753 | vanadium(0) | multiple interactions | ISO | RGD:1331958 | 6480464 | PRKCI protein mutant form inhibits the reaction [Vanadium results in increased phosphorylation of and results in increased activity of AKT1 protein] | CTD | PMID:14971662 | wogonin | multiple interactions | ISO | RGD:732937 | 6480464 | wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of PRKCI protein] | CTD | PMID:21295103 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Endocytosis |
| Hippo signaling pathway | |
| Insulin signaling pathway | |
| Tight junction | |
| Pathway Interaction Database | IL1-mediated signaling events (PID:200089) |
| Insulin Pathway (PID:200014) | |
| Insulin-mediated glucose transport (PID:200196) | |
| Nephrin/Neph1 signaling in the kidney podocyte (PID:200152) | |
| Neurotrophic factor-mediated Trk receptor signaling (PID:200150) | |
| p75(NTR)-mediated signaling (PID:200122) | |
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) (PID:200041) | |
| TNF receptor signaling pathway (PID:200102) | |
References - curated| 1. |
Albert CJ and Ford DA, Am J Physiol. 1999 Feb;276(2 Pt 2):H642-50. |
| 2. |
Corsini E, etal., Br J Dermatol. 2009 Jan;160(1):16-25. Epub 2008 Oct 11. |
| 3. |
Dermitzaki E, etal., Biochem Biophys Res Commun. 2005 Feb 18;327(3):828-36. |
| 4. |
GOA data from the GO Consortium |
| 5. |
Izumi Y, etal., J Cell Biol 1998 Oct 5;143(1):95-106. |
| 6. |
Kim YB, etal., J Biol Chem 2002 Sep 6;277(36):32915-22. |
| 7. |
Kojima Y, etal., Hum Pathol. 2008 Jun;39(6):824-31. |
| 8. |
Matsumoto M, etal., J Clin Invest. 2003 Sep;112(6):935-44. |
| 9. |
MGD data from the GO Consortium |
| 10. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 11. |
Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24. |
| 12. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 13. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 14. |
RGD automated data pipeline |
| 15. |
RGD automated import pipeline for gene-chemical interactions |
| 16. |
RGD comprehensive gene curation |
| 17. |
Rosse C, etal., PLoS Biol. 2009 Nov;7(11):e1000235. Epub 2009 Nov 3. |
| 18. |
Sugita M, etal., Biochim Biophys Acta. 2010 Jan;1801(1):70-6. Epub 2009 Sep 24. |
| 19. |
Suzuki A and Ohno S, J Cell Sci. 2006 Mar 15;119(Pt 6):979-87. |
| 20. |
Tisdale EJ, etal., J Biol Chem 2003 Sep 26;278(39):38015-21. |
| 21. |
Watanuki S, etal., Br J Pharmacol. 2004 Jan;141(2):347-59. Epub 2003 Dec 22. |
| 22. |
Weichert W, etal., Int J Oncol. 2003 Sep;23(3):633-9. |
References - uncuratedRGD Disease Portals| Prkci has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Prkci (Rattus norvegicus) |
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| PRKCI (Homo sapiens) |
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| Prkci (Mus musculus) |
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Position Markers| RH143812 |
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| AI406627 |
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| AI007955 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_032059 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06015611 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06015612 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06015613 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01016016 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01016017 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01016018 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01016019 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB020615 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473961 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU517502 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U85006 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_032059 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_114448 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_114448 | (Get FASTA) |
| GenBank Protein | AAB41799 | (Get FASTA) |
| ACA66272 | (Get FASTA) | |
| BAA78372 | (Get FASTA) | |
| EDM01152 | (Get FASTA) | |
| F1M7Y5 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000009652 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000012924 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000012924 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 84006 | ENTREZGENE |
| HomoloGene Group ID | 37667 | ENTREZGENE |
| InterPro | AGC-kinase_C | UniProtKB/Swiss-Prot |
| DAG/PE-bd | UniProtKB/Swiss-Prot | |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| OPR_PB1 | UniProtKB/Swiss-Prot | |
| PKC_zeta | UniProtKB/Swiss-Prot | |
| Pkinase_C | UniProtKB/Swiss-Prot | |
| Prot_Kinase_C-like_PE/DAG-bd | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser/Thr_kinase_AS | UniProtKB/Swiss-Prot | |
| Ser/Thr_kinase_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00914259 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| KEGG Report | rno:84006 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | C1_1 | UniProtKB/Swiss-Prot |
| PB1 | UniProtKB/Swiss-Prot | |
| Pkinase | UniProtKB/Swiss-Prot | |
| Pkinase_C | UniProtKB/Swiss-Prot | |
| PIRSF | PKC_zeta | UniProtKB/Swiss-Prot |
| PRINTS | DAGPEDOMAIN | UniProtKB/Swiss-Prot |
| PROSITE | AGC_KINASE_CTER | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| ZF_DAG_PE_1 | UniProtKB/Swiss-Prot | |
| ZF_DAG_PE_2 | UniProtKB/Swiss-Prot | |
| SMART | PB1 | UniProtKB/Swiss-Prot |
| S_TK_X | UniProtKB/Swiss-Prot | |
| S_TKc | UniProtKB/Swiss-Prot | |
| SM00109 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| UniGene | Rn.1388 | ENTREZGENE |
| UniProt | KPCI_RAT | UniProtKB/Swiss-Prot |
| Q9R1X8_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2006-03-30 | Prkci | protein kinase C, iota | Pkcl | protein kinase C, lambda | Symbol and Name updated | 10779 | APPROVED |
| 2002-08-07 | Pkcl | protein kinase C, lambda | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_process | mediates protein transport in the early secretory pathway | 724652 |
| gene_regulation | activated by phosphatidylinositol 3,4,5-triphosphate and phosphatidic acid | 724652 |
| More on Prkci | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620961 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.