Gene: Smad4 (SMAD family member 4) Rattus norvegicus
Symbol: Smad4
Name: SMAD family member 4
Description: ENCODES a protein that exhibits DNA binding; filamin binding; SMAD binding; INVOLVED IN anterior/posterior pattern specification (ortholog); atrioventricular canal development (ortholog); atrioventricular valve formation (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH Adenomatous Polyposis Coli (ortholog); Carcinoma, Renal Cell (ortholog); Carcinoma, Transitional Cell (ortholog); FOUND IN cytoplasm; nucleus; protein complex; INTERACTS WITH 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MAD (mothers against decapentaplegic Drosophila) homolog 4; MAD (mothers against decapentaplegic, Drosophila) homolog 4; MAD homolog 4; MAD homolog 4 (Drosophila); Madh4; mothers against decapentaplegic homolog 4; mothers against DPP homolog 4; SMAD 4
Latest Assembly: RGSC Genome Assembly v5.0
RGSC Genome Assembly v6.01869,627,824 - 69,657,301-NCBI
Rat Cytogenetic Map18q12.3 NCBI
RGSC Genome Assembly v5.01868,773,326 - 68,802,354-NCBI
RGSC Genome Assembly v3.41870,432,705 - 70,461,541-NCBI
Rat Celera Assembly1865,247,184 - 65,276,408-NCBI
Genome Assembly 3.11870,504,785 - 70,534,814-NCBI

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Comparative Map Data
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QTLs in Region (RGSC Genome Assembly v5.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Smad4
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RGD Object Information
RGD ID: 3033
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2016-01-26
Status: ACTIVE