PANCREATIC CANCER PATHWAY (PW:0000626)

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Description

Pancreatic cancer is the fourth leading cause of cancer-related deaths. It equally affects both men and women and continues to have a very low overall 5-year survival rate of less than 5%. Pancreatic ductal adenocarcinoma (PDAC) is the predominant form with several precursor lesions such as pancreatic intraepithelial neoplasia (PanIN) graded stage I to III. Other lesions include the intraductal papillary mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN). The driver oncogene is believe

Pathway Diagram:

Elsevier Inc. Smarca4 Arid1a Arid1b Pbrm1 Actl6a altered SWI/SNF family mediated chromatin remodeling pathway ---> genome instability altered p53 signaling pathway ---> altered cellular events altered cellular events altered p53 signaling pathway altered p53 signaling pathway ---> altered expression of target genes altered p53 signaling pathway ---> genome instability genome instability Ilk Itga4 altered integrin mediated signaling pathway ---> altered cellular events altered Wnt signaling, canonical pathway ---> altered expression of target genes altered transforming growth factor-beta Smad dependent signaling pathway ---> altered expression of target genes altered integrin mediated signaling pathway altered G1/S transition pathway ---> genome instability altered expression of target genes altered Wnt signaling, canonical pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes altered Hedgehog signaling pathway ---> altered expression of target genes downregulated miRNA ---> upregulated target translation Tp53 Kras Pten Tcf7l2 Smad3 Smad4 Tgfbr2 Lrp2 Gli3 Gli1 Shh Boc Cdkn2a upregulated miRNA ---> downregulated target translation Pancreatic Neoplasms Egfr altered regulation of target genes altered epidermal growth factor/neuregulin signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway altered epidermal growth factor/neuregulin signaling pathway Tgfa Egf altered extracellular signal-regulated Raf/Mek/Erk signaling pathway Akt2 altered scatter factor/hepatocyte growth factor signaling pathway altered transforming growth factor-beta Smad dependent signaling pathway Wnt9a upregulated target translation potential pancreatic cancer miRNA altered SWI/SNF family mediated chromatin remodeling pathway altered G1/S transition pathway Itga9 altered scatter factor/hepatocyte growth factor signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway altered scatter factor/hepatocyte growth factor signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered epidermal growth factor/neuregulin signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway Met altered Hedgehog signaling pathway Itga11 downregulated target translation upregulated miRNA downregulated miRNA altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered Hedgehog signaling pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered regulation of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered regulation of target genes potential pancreatic cancer miRNA ---> Pancreatic Neoplasms
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Genes in Pathway:

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pancreatic cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actl6a actin-like 6A JBrowse link 2 119,112,776 119,128,870 RGD:8694154
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:5490965
RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 JBrowse link X 159,722,031 159,841,344 RGD:6907045
G Arid1a AT-rich interaction domain 1A JBrowse link 5 151,904,687 151,977,973 RGD:8694154
G Arid1b AT-rich interaction domain 1B JBrowse link 1 45,923,119 46,232,301 RGD:8694154
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6907045
G Boc BOC cell adhesion associated, oncogene regulated JBrowse link 11 61,084,216 61,159,220 RGD:5490966
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6907045
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6907045
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6907045
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:5490966
RGD:6907045
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6907045
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6907045
G E2f3 E2F transcription factor 3 JBrowse link 17 36,334,136 36,408,831 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:5490965
RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:5490965
RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:6907045
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:5490966
RGD:5491005
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:5490966
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6907045
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:5490966
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,874 67,683,973 RGD:5490966
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:5490966
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,271,029 127,576,709 RGD:5490966
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:5490965
RGD:5490966
RGD:6907045
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:5490966
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:5490965
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6907045
G Pbrm1 polybromo 1 JBrowse link 16 7,103,714 7,202,899 RGD:8694154
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pld1 phospholipase D1 JBrowse link 2 113,651,967 113,849,403 RGD:6907045
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:5490965
G Rac1 ras-related C3 botulinum toxin substrate 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) JBrowse link 7 119,769,708 119,797,111 RGD:6907045
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rala RAS like proto-oncogene A JBrowse link 17 49,676,073 49,729,133 RGD:6907045
G Ralb RAS like proto-oncogene B JBrowse link 13 35,494,716 35,531,503 RGD:6907045
G Ralbp1 ralA binding protein 1 JBrowse link 9 113,579,107 113,598,477 RGD:6907045
G Ralgds ral guanine nucleotide dissociation stimulator JBrowse link 3 7,090,134 7,130,548 RGD:6907045
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6907045
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6907045
G Shh sonic hedgehog JBrowse link 4 718,538 727,691 RGD:5490965
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:6907045
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:5490966
RGD:6907045
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:5490965
RGD:5490966
RGD:6907045
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 8 22,648,323 22,739,468 RGD:8694154
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6907045
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6907045
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:5490966
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:5490965
RGD:6907045
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6907045
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6907045
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:6907045
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:5490965
RGD:5490966
RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:5490966
RGD:6907045
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6907045
G Vegfb vascular endothelial growth factor B JBrowse link 1 222,237,000 222,242,786 RGD:6907045
G Vegfc vascular endothelial growth factor C JBrowse link 16 40,440,371 40,555,178 RGD:6907045
G Vegfd vascular endothelial growth factor D JBrowse link X 31,816,480 31,852,239 RGD:6907045
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:5490966

Pathway Gene Annotations

Disease Annotations Associated with Genes in the pancreatic cancer pathway
Disease TermsGene Symbols
Abnormalities, MultipleArid1b , Cdc42 , Chuk , Kras , Mapk1 , Pld1 , Pten , Smad2 , Smarca4
Abortion, SpontaneousPgf , Tgfb1 , Tgfbr1
Absence of Tibia with PolydactylyShh
Acro-OsteolysisSmad4
Acrocallosal SyndromeGli3
Acromicric DysplasiaSmad2 , Tgfb1
Acute Chest SyndromeVegfa
Acute Kidney InjuryBad , Bcl2l1 , Egf , Egfr , Met , Rb1 , Tgfa , Tgfb1 , Tp53 , Vegfa
Acute Lung InjuryEgfr , Tgfb1 , Vegfa
AdenocarcinomaArid1a , Ccnd1 , Cdkn2a , Egf , Egfr , Erbb2 , Kras , Met , Nfkb1 , Pik3ca , Pten , Stat3 , Tcf7l2 , Tgfb1 , Tp53 , Vegfa
Adenocarcinoma of EsophagusArid1a , Cdkn2a , Pik3ca , Smad4 , Tp53
Adenocarcinoma of LungAkt1 , Braf , Cdk4 , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Pik3ca , Raf1 , Smad4 , Tp53
Adenocarcinoma, Bronchiolo-AlveolarEgfr , Kras , Tp53
Adenocarcinoma, Clear CellTp53
Adenocarcinoma, ColorectalBcl2l1
Adenocarcinoma, FollicularKras
Adenocarcinoma, ProstaticAkt1 , Braf , Cdkn2a , Erbb2 , Map2k1 , Pik3ca , Pten , Smad4 , Tp53
AdenomaBcl2l1 , Kras , Tp53
Adenoma, Liver CellKras , Pten
Adenomatous Polyposis ColiAkt1 , Egfr
Adrenal Gland NeoplasmsCdc42 , Cdkn2a , Rb1 , Tp53
Adrenocortical CarcinomaBraf , Cdkn2a , Egfr , Pik3ca , Rb1 , Tp53
Adrenocortical Carcinoma, HereditaryTp53
Adrenocortical Carcinoma, PediatricTp53
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Aging, PrematureCdkn2a , Tp53
AIDS-Associated NephropathyEgf
AlbuminuriaLrp2
Alveolitis, Extrinsic AllergicVegfa
Alzheimer DiseaseAkt1 , Bad , Bcl2l1 , Cdc42 , E2f1 , Egf , Egfr , Ikbkb , Mapk10 , Mapk8 , Mapk9 , Pik3r1 , Stat3 , Tp53 , Vegfa
AmeloblastomaBraf
Amphetamine-Related DisordersAkt1 , Rela
Amyotrophic Lateral SclerosisAkt1 , Casp9 , Pgf , Tp53 , Vegfa
Amyotrophic Lateral Sclerosis 1Bcl2l1
AnemiaKras
Anemia, AplasticTgfb1
Anemia, Nonspherocytic Hemolytic, due to G6pd DeficiencyIkbkg
Anemia, Sickle CellPgf , Tgfb1
AnetodermaTgfb1
AneurysmSmad3 , Tgfbr2
Aneurysm, DissectingSmad3 , Tgfbr1 , Tgfbr2
Angina, UnstableAkt1
AngiomyolipomaPten , Stat1 , Stat3
AnisometropiaPten
AnodontiaGli3
Anorectal AtresiaGli3 , Shh
AnoxiaPgf , Rad51
Anti-Glomerular Basement Membrane DiseaseItga4 , Mapk8
Aortic AneurysmSmad3 , Tgfbr1 , Tgfbr2
Aortic Aneurysm, AbdominalMapk8
Aortic Aneurysm, Familial Thoracic 1Tgfbr2
Aortic Aneurysm, Familial Thoracic 3Tgfbr2
Aortic Aneurysm, ThoracicSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
Aortic DiseasesSmad4
Aortic Valve InsufficiencyEgfr , Tgfb1 , Tgfb2
Aortic Valve StenosisEgfr
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arrhythmogenic Right Ventricular DysplasiaTgfb3
Arrhythmogenic Right Ventricular Dysplasia, Familial, 1Tgfb3
Arsenic PoisoningTp53
ArteriosclerosisMapk9 , Met , Rela , Tgfb1 , Tgfbr2
Arteriovenous FistulaVegfa
Arthritis, ExperimentalAkt1 , Cdc42 , Cdkn2a , Egfr , Gli1 , Ikbkb , Ikbkg , Itga4 , Pgf , Pik3cd , Shh , Stat1 , Stat3 , Tgfbr2 , Vegfa
Arthritis, JuvenileEgf , Kras , Mapk1 , Smad3 , Stat3 , Tcf7l2
Arthritis, PsoriaticStat3
Arthritis, RheumatoidCdk6 , Pgf , Stat1 , Stat3 , Vegfa
AsthmaChuk , Egfr , Pgf , Pten , Tgfb1 , Vegfa
Asthma, OccupationalTgfb1
AstrocytomaAkt1 , Braf , Kras , Met , Tp53
AtaxiaPten
Ataxia-Oculomotor Apraxia 3Pik3r5
AtherosclerosisAkt1 , Pgf , Stat3 , Vegfa , Vegfc
Atrial FibrillationVegfa
Atrioventricular Septal DefectShh
AtrophyMapk3 , Stat3
Attention Deficit Disorder with HyperactivityVegfa
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
Auditory Neuropathy, Autosomal Dominant, 1Tgfbr1
Autism Spectrum DisorderMapk3 , Pten , Shh
Autistic DisorderEgf , Itga4 , Met , Pten , Stat3
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1Stat3
Autoimmune DiseasesStat3 , Tgfb2
Autoimmune Lymphoproliferative Syndrome, Type IVKras
Bacterial InfectionsCasp9
Balkan NephropathyTp53
Bardet-Biedl SyndromeAkt3
Barrett EsophagusRela
Basal Cell Nevus SyndromeGli1 , Shh
Behcet SyndromeIkbkg , Stat3 , Tgfb1 , Vegfa
BerylliosisTgfb1
Bile Duct NeoplasmsEgfr , Met
Biliary AtresiaPten , Shh
Bipolar DisorderAkt1 , Cdc42
BlepharophimosisArid1b
BlindnessVegfa
Bone DiseasesTgfbr2
Bone Diseases, DevelopmentalChuk , Tgfb2 , Tp53
Bone Diseases, MetabolicLrp2
Bone Marrow NeoplasmsTp53
Bone NeoplasmsTgfbr2
BrachydactylySmad4
Brachydactyly Type A1Shh
Brain EdemaVegfa
Brain InjuriesAkt1 , Bad , Rela , Stat1 , Stat3 , Vegfa , Vegfb
Brain IschemiaAkt1 , Bad , Bcl2l1 , Casp9 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Nfkb1 , Pgf , Rb1 , Rela , Stat3 , Tgfb1 , Tp53
Brain NeoplasmsCcnd1 , Cdk4 , Cdkn2a , Egfr , Pten , Rela , Tp53 , Vegfa
Brain Stem NeoplasmsCdk4 , Cdk6 , Cdkn2a
Breast AdenocarcinomaAkt1 , Kras , Pik3ca , Tp53
Breast Cancer, FamilialBrca2 , Pik3r3 , Rad51
Breast NeoplasmsAkt1 , Akt2 , Bad , Bcl2l1 , Braf , Brca2 , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , Egf , Egfr , Erbb2 , Ikbkb , Kras , Map2k1 , Mapk1 , Met , Pgf , Pik3ca , Pik3r1 , Pten , Rad51 , Raf1 , Rb1 , Rela , Smad2 , Smad4 , Stat1 , Stat3 , Tgfb1 , Tp53 , Vegfa , Vegfb , Vegfc , Wnt9a
Breast Neoplasms, MaleBrca2
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Akt1 , Brca2 , Pik3ca
Breast-Ovarian Cancer, Familial, Susceptibility To, 2Brca2
Bronchitis, ChronicVegfa
Burkitt LymphomaArid1a , Pik3r1 , Smarca4
BurnsBad , Ccnd1
CachexiaTgfb1
CalcinosisErbb2 , Tgfb1
Camurati-Engelmann SyndromeTgfb1
Candidiasis, Chronic MucocutaneousStat1
Candidiasis, Familial, 7Stat1
CarcinogenesisBraf , Cdkn2a , Erbb2 , Kras
CarcinomaBcl2l1 , Ccnd1 , Cdc42 , Cdk4 , Egfr , Kras , Met , Pik3r1 , Pten , Rb1 , Stat3 , Tgfb1 , Tgfbr2 , Tp53
Carcinoma in SituAkt1 , Cdkn2a , Pten , Rb1
Carcinoma, Adenoid CysticArid1a , Ccnd1 , Pik3ca , Pten , Tp53
Carcinoma, Basal CellErbb2 , Pik3ca , Rb1 , Shh , Tp53
Carcinoma, Ductal, BreastBrca2 , Cdkn2a , Smad4
Carcinoma, EmbryonalRb1
Carcinoma, EndometrioidEgfr , Erbb2 , Kras , Pten
Carcinoma, HepatocellularAkt1 , Akt2 , Arid1a , Arid1b , Bcl2l1 , Braf , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , Egf , Egfr , Gli1 , Kras , Met , Pik3ca , Pten , Rac1 , Rb1 , Shh , Smad2 , Smad4 , Stat1 , Tgfa , Tgfb1 , Tgfbr2 , Tp53
Carcinoma, Intraductal, NoninfiltratingBrca2 , Ccnd1 , Erbb2 , Rb1 , Rela , Tp53 , Vegfa
Carcinoma, Large CellMet
Carcinoma, LobularCcnd1 , Erbb2
Carcinoma, Non-Small-Cell LungAkt1 , Akt2 , Braf , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Met , Pik3ca , Pten , Raf1 , Rb1 , Rela , Stat3 , Tgfa , Tp53 , Vegfa
Carcinoma, Pancreatic DuctalCdkn2a , Egf , Kras , Met , Tgfb1 , Tgfbr2 , Vegfa
Carcinoma, PapillaryVegfc
Carcinoma, Renal CellAkt1 , Bad , Bcl2l1 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Met , Pbrm1 , Pik3ca , Pten , Rb1 , Rela , Smad2 , Smad4 , Stat3 , Tp53 , Vegfa , Vegfc
Carcinoma, Small CellRb1 , Smarca4 , Tp53
Carcinoma, Squamous CellAkt1 , Ccnd1 , Cdkn2a , Egfr , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Stat3 , Tgfb1 , Tp53 , Vegfa
Carcinoma, Squamous Cell of Head and NeckAkt1 , Braf , Cdkn2a , Egfr , Erbb2 , Map2k1 , Mapk1 , Pik3ca , Pten , Rac1 , Smad4 , Stat3 , Tp53
Carcinoma, Transitional CellArid1a , Bcl2l1 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Kras , Smad4 , Tp53
CarcinosarcomaTgfb1
Cardiac FibrosisTgfb1
Cardiofaciocutaneous SyndromeBraf , Kras , Map2k1
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
CardiomegalyAkt1 , Bad , Egfr , Mapk1 , Mapk8 , Met , Pld1 , Pten , Rac1 , Rb1 , Rela , Stat3 , Tgfb1
CardiomyopathiesAkt1 , Ilk , Kras , Mapk1 , Mapk3 , Rad51 , Stat3 , Tp53 , Vegfa
Cardiomyopathy, DilatedEgfr , Erbb2 , Ilk , Kras , Pgf , Rac1 , Raf1
CARDIOMYOPATHY, DILATED, 1NNRaf1
Cardiomyopathy, HypertrophicIlk , Kras , Raf1 , Tgfb1 , Tp53
Cardiomyopathy, Hypertrophic, FamilialIlk , Kras , Raf1
Cardiovascular AbnormalitiesMap2k1
Carotid Artery DiseasesPgf , Tgfb1 , Tp53
CataractBrca2 , Map2k1 , Pten , Tp53
Cecal NeoplasmsCcnd1 , Kras , Tp53
Cell Transformation, NeoplasticCcnd1 , Egf , Kras , Mapk8 , Nfkb1 , Rac1 , Rela , Stat3 , Tgfb1 , Tp53
Central Nervous System NeoplasmsTp53
Cerebral HemorrhageBcl2l1 , Nfkb1 , Rela , Vegfa
Ceroid Lipofuscinosis, Neuronal, 6Mapk1 , Mapk3
Cervical Intraepithelial NeoplasiaCcnd1 , Cdk4 , Cdkn2a , Pten , Rb1 , Rela , Stat3 , Vegfa
Chemotherapy-Induced Febrile NeutropeniaTp53
ChloracneCdk6 , Egfr
CholangiocarcinomaArid1a , Egfr , Erbb2 , Kras , Met , Pbrm1 , Pten , Smad4 , Tgfb1 , Tgfbr2 , Tp53
CholangitisTgfb2
CholestasisRela
CholesteatomaVegfa
Cholesteatoma, Middle EarRela , Tp53 , Vegfa
ChorioamnionitisTgfb1
Choroid Plexus CarcinomaTp53
Choroidal NeovascularizationIkbkb , Stat3 , Vegfa , Vegfb
Chromosome 17 DeletionTp53
Chromosome AberrationsCdk6
Chromosome DeletionCdkn2a
CHROMOSOME Xq26.3 DUPLICATION SYNDROMEArhgef6
Chronic Lymphoid LeukemiaBraf , Kras , Tp53
Chronic PeriodontitisRac2
Churg-Strauss SyndromeStat3
CicatrixSmad4
Clear-Cell Metastatic Renal Cell CarcinomaVegfa
Cleft PalateChuk , Egf , Gli3 , Shh , Tgfb1 , Tgfb2 , Tgfb3
ClubfootGli3
Cocaine-Related DisordersIlk , Mapk1 , Mapk3
Cocoon SyndromeChuk
Coffin-Siris SyndromeArid1a , Arid1b , Smarca4
Cognition DisordersMet , Smad4
ColitisChuk , Ikbkb , Pgf , Rela , Vegfa
Colitis, ExperimentalItga4 , Smad4
Colitis, IschemicVegfa
Colitis, UlcerativeTp53
ColobomaShh
Colonic NeoplasmsAkt1 , Akt2 , Bad , Braf , Brca2 , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Ikbkb , Kras , Nfkb1 , Pik3ca , Pik3r1 , Pten , Rela , Stat3 , Tcf7l2 , Tgfbr2 , Tp53 , Vegfa , Vegfc
Colonic PolypsIlk
Colorectal Cancer, Hereditary Nonpolyposis, Type 6Tgfbr2
Colorectal NeoplasmsAkt1 , Akt2 , Arid1a , Braf , Brca2 , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Met , Pik3ca , Pik3r1 , Pten , Raf1 , Smad4 , Tcf7l2 , Tgfb1 , Tgfbr1 , Tp53
Colorectal Neoplasms, Hereditary NonpolyposisSmad2 , Smad3 , Smad4 , Tgfbr1 , Tgfbr2
Congenital AbnormalitiesRac2
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Conjunctivitis, AllergicTgfb1
ConstipationArid1b
Copper-Overload CirrhosisMet , Smad2 , Stat3 , Tgfb1
Corneal NeovascularizationVegfa
Coronary Artery DiseaseAkt1 , Tgfb1 , Vegfa
Coronary DiseaseVegfa
Coronary RestenosisMapk1 , Tp53
Costello SyndromeBraf , Kras , Map2k1
COWDEN SYNDROME 5Pik3ca
Cranioectodermal DysplasiaTgfb3
Craniofacial AbnormalitiesEgfr , Lrp2 , Pten , Smad2 , Smad3 , Smad4 , Tgfb2 , Tgfbr2 , Tp53
CraniopharyngiomaBraf
Crohn DiseasePgf , Smad3 , Stat3 , Vegfa
Crossed Polydactyly, Type IGli3
CryptorchidismArid1b , Bcl2l1 , Rela
Currarino TriadActl6a , Pik3ca
CyanosisTgfb2
Cystadenocarcinoma, SerousTp53
Cystic FibrosisTgfb1
CystitisRela
Cytomegalovirus InfectionsStat1
DeafnessSmad4
Deafness, Autosomal Recessive 97Met
DementiaE2f1 , Egfr
Dementia, VascularTp53
Demyelinating DiseasesShh , Tp53
Depressive DisorderBcl2l1
DermatitisIkbkb
Dermatitis HerpetiformisVegfa
Dermatitis, Allergic ContactVegfa
Dermatitis, AtopicMapk8 , Tgfb1
Dermatitis, ContactVegfa
Dermatitis, IrritantStat3
Developmental DisabilitiesAkt3 , Lrp2 , Pten
Diabetes ComplicationsVegfa
Diabetes MellitusPten , Rac1 , Tcf7l2
Diabetes Mellitus, ExperimentalAkt1 , Bad , Bcl2l1 , Casp9 , Egfr , Ikbkb , Lrp2 , Mapk1 , Mapk3 , Met , Pgf , Pik3r1 , Rela , Smarca4 , Stat1 , Stat3 , Tgfb1 , Tgfb2 , Tp53 , Vegfa , Vegfb
Diabetes Mellitus, Type 1Casp9 , Cdk4 , E2f1 , Egfr , Stat3 , Tgfb1
Diabetes Mellitus, Type 2Akt1 , Akt2 , Bad , Bcl2l1 , Casp9 , Cdk4 , Egfr , Ikbkb , Nfkb1 , Pik3r1 , Rela , Smad4 , Stat3 , Tcf7l2 , Tgfb1 , Tgfbr2 , Vegfa
Diabetes, GestationalTcf7l2
Diabetic AngiopathiesRela , Vegfa
Diabetic CardiomyopathiesBad , Erbb2
Diabetic CystopathyBad
Diabetic NephropathiesEgf , Mapk1 , Pgf , Pten , Rela , Stat3 , Tcf7l2 , Tgfb1 , Tgfbr2 , Tp53 , Vegfa
Diabetic NeuropathiesBad , Pgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa
Diabetic RetinopathyCasp9 , Egfr , Itga4 , Pgf , Vegfa
Diaphyseal Dysplasia 1, ProgressiveTgfb1
Dilatation, PathologicTgfb1
Disease Models, AnimalAkt1 , Erbb2 , Kras , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Stat3 , Tp53
Disease ProgressionEgf , Egfr , Erbb2 , Pten , Stat1 , Vegfb
Donnai-Barrow SyndromeLrp2
Drug-Induced Liver InjuryBad
Drug-induced NeutropeniaTp53
Drug-Related Side Effects and Adverse ReactionsTp53
Dry Eye SyndromesTgfb1
Duodenal UlcerStat3 , Tgfb1 , Vegfa
Dysembryoplastic Neuroepithelial TumorBraf
Dyskeratosis Congenita, Autosomal RecessiveTp53
Dyskinesia, Drug-InducedRela
Dysplastic Nevus SyndromeCdkn2a
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Ectodermal Dysplasia, Hypohidrotic, with Immune DeficiencyIkbkg
EdemaCasp9
Ehlers-Danlos SyndromeTgfb1
EmphysemaTp53
EncephalitisRela
Encephalitis, ViralE2f1
Encephalomyelitis, Autoimmune, ExperimentalCasp9 , Gli1 , Itga4 , Shh , Stat1 , Stat3 , Tgfb1 , Tgfb2 , Vegfa
Endometrial HyperplasiaKras , Pten
Endometrial NeoplasmsArid1a , Bcl2l1 , Brca2 , Ccnd1 , Cdk4 , Cdkn2a , Erbb2 , Kras , Met , Pik3ca , Pten , Rb1 , Smad2 , Smad3 , Smad4 , Stat3 , Tp53 , Vegfa
EndometriosisBcl2l1 , Egfr , Kras , Tgfb2 , Vegfa
Endomyocardial FibrosisTgfb1
EndotoxemiaPgf
Enterocolitis, NecrotizingEgf , Ikbkg
Eosinophilic EsophagitisTgfb1
Epidermal HyperplasiaStat3
Epidermal NevusKras , Pik3ca
EpilepsyAkt1 , Arid1b , Ilk , Pgf
Epilepsy, GeneralizedMapk10
Epilepsy, Temporal LobeCdc42 , Pgf , Shh , Vegfa
Epileptic Encephalopathy, Lennox-Gastaut TypeMapk10
Erectile DysfunctionAkt1 , Bad , Bcl2l1 , Ccnd1 , Tgfb1 , Vegfa
Erythema MultiformeVegfa
Esophageal Atresia with or without Tracheoesophageal FistulaShh
Esophageal NeoplasmsCcnd1 , Cdkn2a , Egfr , Erbb2 , Met , Tgfbr2 , Tp53
Esophageal Squamous Cell CarcinomaBrca2 , Ccnd1 , Cdkn2a , Egfr , Rb1 , Tp53
Esophagitis, PepticEgfr
Eye AbnormalitiesShh , Tgfb2 , Tgfbr2
Eye Diseases, HereditaryLrp2
Facial AsymmetryPik3ca
Failure to ThriveArid1b
Familial SchizencephalyShh
Fanconi AnemiaBrca2
Fanconi Anemia, Complementation Group D1Brca2
FANCONI ANEMIA, COMPLEMENTATION GROUP RRad51
FatigueTgfbr2
Fatty LiverMapk8 , Nfkb1 , Pten , Rela
Fetal Alcohol Spectrum DisordersPten
Fetal DiseasesChuk
FeverStat3
FibrosarcomaCdc42
FibrosisAkt1 , Stat3 , Tgfb1
Fluoride PoisoningGli1 , Shh
Fractures, BoneTgfbr2
Gallbladder NeoplasmsEgf , Egfr , Erbb2 , Kras , Met , Tgfa , Tgfb1 , Tp53
GastrinomaMet
GastroenteritisTgfa
Gastrointestinal NeoplasmsErbb2 , Pik3ca , Pten , Smad4
Gastrointestinal Stromal TumorsBraf , Kras
Genetic Diseases, InbornArid1a , Arid1b , Brca2 , Cdc42 , Itga11 , Jak1 , Mapk1 , Pik3r2 , Pld1 , Pten , Smad2 , Smarca4
Genetic Predisposition to DiseaseEgf , Rad51 , Tgfa
Genital Diseases, FemaleSmad2
Genomic InstabilityCcnd1
GerminomaBraf , Cdkn2a
GingivitisVegfa
GlaucomaBad , Cdkn2a , Tgfb2 , Vegfa
Glaucoma, NeovascularVegfa
Glaucoma, Primary Open AngleTp53
GlioblastomaAkt1 , Braf , Cdk6 , Cdkn2a , Egf , Egfr , Erbb2 , Met , Pgf , Pik3ca , Pik3r1 , Pten , Tp53 , Vegfa
GliomaAkt2 , Bad , Braf , Brca2 , Cdkn2a , Egfr , Erbb2 , Met , Pik3ca , Pten , Raf1 , Tp53
GliosarcomaVegfa
GliosisItga4 , Mapk1 , Mapk3
GlomerulonephritisMapk1 , Vegfa
Glomerulonephritis, IGAShh , Tgfb1
Glomerulonephritis, MembranoproliferativeTgfbr2
Glomerulonephritis, MembranousLrp2 , Shh
Glomerulosclerosis, Focal SegmentalShh , Tgfb1
Glomus Tympanicum TumorVegfa
Glucosephosphate Dehydrogenase DeficiencyIkbkg
Graft vs Host DiseaseTp53 , Vegfa
Granuloma, PyogenicStat3
Granulosa Cell TumorCdkn2a , Vegfa
Graves DiseaseTp53 , Vegfa
Greig cephalopolysyndactyly syndromeGli3
Growth DisordersPik3ca
Growth Mental Deficiency Syndrome of MyhreSmad4
Hamartoma Syndrome, MultipleAkt1 , Egfr , Pik3ca , Pten
Head and Neck NeoplasmsBcl2l1 , Egfr , Mapk1 , Mapk3 , Pik3ca , Rad51 , Tgfa , Tp53 , Vegfa
Hearing LossBcl2l1 , Stat1
Hearing Loss, SensorineuralLrp2
Heart ArrestAkt1
Heart Defects, CongenitalTgfb2 , Vegfa
Heart DiseasesCasp9 , Rac2 , Stat3 , Tgfb1 , Vegfa
Heart FailureErbb2 , Pgf , Rac1 , Tp53 , Vegfa
Heart Septal Defects, VentricularBraf , Pgf , Smarca4 , Tgfb3
Heat StrokeNfkb1 , Rela
HELLP SyndromeErbb2
HemangiomaPten
Hemangioma, CapillaryAkt3
Hemangioma, Cavernous, Central Nervous SystemPten
HemangiosarcomaCcnd1 , Kras , Stat3 , Tp53 , Vegfa , Vegfc
Hematologic DiseasesBcl2l1 , Brca2
HemimegalencephalyPik3ca
Hemophilia ATgfb1
Hepatitis C, ChronicStat3
Hepatitis, AnimalMet
Hepatitis, AutoimmuneTgfb1
Hepatitis, ChronicMet , Smad2 , Stat3 , Tgfb1
HepatoblastomaTgfa , Tp53
HepatomegalyPten
Hereditary Breast and Ovarian Cancer SyndromeBrca2
Hernia, DiaphragmaticLrp2 , Tgfb1
Hernia, InguinalTgfbr2
Hernias, Diaphragmatic, CongenitalMet , Stat3 , Vegfa
High MyopiaLrp2
Hirschsprung DiseaseErbb2 , Shh
HIV InfectionsCdc42
HoloprosencephalyShh
Holoprosencephaly 3Shh
Holt-Oram SyndromeTgfb2
Huntington DiseaseE2f1 , Egfr , Nfkb1
Hyper-Ige Recurrent Infection Syndrome, Autosomal DominantStat3
Hyper-IgM Immunodeficiency, X-Linked, with Ectodermal Dysplasia, HypohidroticIkbkg
HyperalgesiaMapk1 , Mapk3 , Mapk8 , Mapk9 , Raf1 , Stat3
HypercholesterolemiaVegfa
HyperinsulinismPten
HyperlipidemiasTgfb1
HyperoxaluriaNfkb1
HyperoxiaCdk4 , Tgfb1
Hyperoxic Lung InjuryShh
HyperparathyroidismCcnd1
HyperplasiaAkt1 , Ccnd1 , Cdkn2a , Egfr , Ikbkb , Pik3ca , Tcf7l2 , Tgfb1 , Tgfbr2 , Vegfa
HypersensitivityTgfb1
Hypersensitivity, ImmediateEgfr
HypertensionAkt1 , Akt2 , Arid1b , Bad , Cdkn2a , Egfr , Ikbkb , Kras , Lrp2 , Mapk8 , Pgf , Pik3r1 , Pten , Rad51 , Ralbp1 , Rela , Tgfb1 , Tgfb3 , Tp53 , Vegfa
Hypertension, PortalPik3r1 , Pten , Vegfa
Hypertension, PulmonaryBcl2l1 , Egfr , Pgf , Rela , Smad4 , Tgfa , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfb
Hypertension, RenovascularRela
HypertrichosisArid1b
HypertrophyMapk1 , Mapk3 , Pten
Hypertrophy, Left VentricularEgfr , Pbrm1 , Pten , Rac1 , Rela , Smarca4
Hypertrophy, Right VentricularAkt1 , Tgfa , Tgfb1
HyperuricemiaStat3
Hypoglossal Nerve InjuriesSmad2 , Smad3 , Smad4
HypoglycemiaAkt2 , Pik3r1
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
Hypomagnesemia 4, RenalEgf
Hypomagnesemia PrimaryEgf
HypopigmentationGli3
HypospadiasGli3
Hypothalamic HamartomasGli3
HypothyroidismBad , Shh
HypotrichosisRb1
Hypotrichosis, Localized, Autosomal Recessive, 3Rb1
Hypoxia-Ischemia, BrainBcl2l1 , Vegfa
Idiopathic Pulmonary FibrosisStat3
Immunodeficiency 14Pik3cd
Immunodeficiency 15Ikbkb
IMMUNODEFICIENCY 31AStat1
Immunodeficiency 36Pik3r1
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
IMMUNODEFICIENCY, COMMON VARIABLE, 12Nfkb1
Impotence, VasculogenicTgfbr2
Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal DementiaEgf
Incontinentia PigmentiIkbkg
Infarction, Middle Cerebral ArteryBad , Ikbkb , Pld1 , Shh , Stat3
Infertility, FemaleMapk1 , Mapk3 , Tp53
Infertility, MaleTp53
InflammationAkt1 , Chuk , Egfr , Pgf , Stat3 , Tgfa , Tgfb1 , Vegfa
Inflammatory Bowel Disease 11Rela , Stat3 , Vegfa
Inflammatory Bowel DiseasesIkbkb , Itga4 , Vegfa
INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 2Egfr
Influenza, HumanStat1
Insulin ResistanceAkt2 , Bad , Egfr , Ikbkb , Pik3r1 , Pten , Rb1 , Rela , Tcf7l2
InsulinomaTgfa , Tgfb1
Intellectual DisabilityArhgef6 , Arid1b , Kras , Pten , Ralgds
Intermittent ClaudicationBad
Intervertebral Disc DegenerationTgfb1
Intervertebral Disc DisplacementAkt1
Intestinal PolyposisGli3 , Smad4
Intestinal PolypsCcnd1
Intestinal Pseudo-ObstructionRb1
Intracranial Arteriovenous MalformationsVegfa
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
Invasive Pulmonary AspergillosisVegfa
Irritable Bowel SyndromeIkbkg
IschemiaAkt2 , Arid1b , Mapk9 , Raf1 , Tp53
Ischemic Attack, TransientBad , Casp9 , Cdkn2a , Ikbkb , Ilk , Nfkb1 , Pten , Stat3
Job SyndromeStat3
Juvenile Polyposis SyndromePten , Smad4
Juvenile Polyposis with Hereditary Hemorrhagic TelangiectasiaSmad4
Keratoacanthoma FamilialTgfbr1
KeratosisTp53
Keratosis, ActinicTgfb1
Keratosis, SeborrheicPik3ca
Kidney DiseasesEgf , Lrp2 , Mapk1 , Tgfb1 , Tgfbr1 , Tgfbr2
Kidney Failure, ChronicLrp2 , Nfkb1 , Pgf , Rela , Tgfb1
Kidney NeoplasmsAkt1 , Braf , Ccnd1 , Cdkn2a , Erbb2 , Kras , Mapk1 , Mapk3 , Met , Raf1
Kidney Reperfusion InjuryIkbkb , Shh
Language Development DisordersPten
Laryngeal NeoplasmsEgfr
Laryngotracheal Stenosis, Progressive, with Short Stature and ArthropathySmad4
Learning DisordersIkbkg , Vegfa
LeiomyomaBcl2l1 , Pten , Smad3 , Tgfbr1
LeiomyosarcomaCdkn2a
LEOPARD SyndromeBraf , Pten , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD syndrome, 2Raf1
LeukemiaBad , Ccnd1 , Cdkn2a , Pten , Tp53
Leukemia, ExperimentalCdkn2a
Leukemia, Hairy CellMap2k1
Leukemia, Large Granular LymphocyticStat3
Leukemia, Lymphocytic, Chronic, B-CellBraf , Ccnd1 , Itga4 , Kras , Tp53
Leukemia, LymphoidBcl2l1
Leukemia, Megakaryoblastic, AcutePten , Tp53
Leukemia, Megakaryoblastic, of Down SyndromeTp53
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveBcl2l1 , Braf , Cdkn2a , Vegfa
Leukemia, MyeloidVegfa
Leukemia, Myeloid, AcuteBcl2l1 , Ccnd1 , Cdk6 , Cdkn2a , Jak1 , Kras , Met , Stat3 , Tp53
Leukemia, Myelomonocytic, JuvenileKras , Rac2
Leukemia, Promyelocytic, AcuteAkt1 , Gli1
Leukemia, T-CellCdkn2a , Stat3
Leukemia-Lymphoma, Adult T-CellStat3 , Tp53
LeukocytosisItga4 , Kras
Leukoplakia, OralTp53
Leydig Cell TumorCdk4
Li-Fraumeni SyndromeTp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni-Like SyndromeTp53
Lichen Planus, OralTp53
Limb Deformities, CongenitalChuk , Shh , Tgfb2
Limb IschemiaVegfa
Lip NeoplasmsTp53
Lipodystrophy, Familial PartialAkt2
LipomaPten
LipomatosisPten
LiposarcomaCdk4
Liver CirrhosisPgf , Smad3 , Stat1 , Stat3 , Tgfb1 , Vegfa
Liver Cirrhosis, AlcoholicRela , Smad3 , Tgfb1
Liver Cirrhosis, BiliaryNfkb1
Liver Cirrhosis, ExperimentalCdk4 , Egf , Ilk , Met , Pgf , Rac2 , Rela , Smad2 , Smad4 , Tgfb1 , Tgfb3 , Tgfbr1 , Tgfbr2 , Vegfa
Liver DiseasesBcl2l1 , Nfkb1 , Rac1
Liver Diseases, ParasiticKras , Smad4 , Tp53
Liver FailureVegfa
Liver Failure, AcuteMapk8 , Met
Liver InjuryStat3
Liver NeoplasmsAkt1 , Braf , Ccnd1 , Cdkn2a , Kras , Met , Pik3ca , Raf1 , Stat3 , Tgfa , Tp53
Liver Neoplasms, ExperimentalBcl2l1 , Ccnd1 , Kras , Map2k1 , Met , Rad51 , Rb1 , Tgfa , Tp53
Liver Reperfusion InjuryBad , Bcl2l1 , Ikbkg , Mapk8
Loeys-Dietz SyndromeSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
LOEYS-DIETZ SYNDROME 2Tgfbr2
Loeys-Dietz Syndrome 3Smad3
Loeys-Dietz Syndrome 4Tgfb2 , Tgfb3
Loeys-Dietz Syndrome 5Tgfb3
Loeys-Dietz Syndrome, Type 1bTgfbr2
Long QT SyndromeIlk , Pten
Low Tension GlaucomaTp53
Lung DiseasesEgfr , Tgfb1 , Vegfa
Lung Diseases, InterstitialTgfb1
Lung InjuryTgfa
Lung NeoplasmsAkt1 , Bcl2l1 , Braf , Brca2 , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Ikbkg , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Pten , Raf1 , Smarca4 , Tgfb1 , Tgfbr2 , Tp53
Lupus Erythematosus, SystemicPgf
Lupus NephritisEgf
LymphangioleiomyomatosisStat1 , Stat3 , Vegfd
Lymphatic MetastasisEgfr , Erbb2 , Pten , Rela , Smad4 , Stat3 , Tp53 , Vegfa , Vegfc , Vegfd
LymphedemaPgf
LYMPHEDEMA, HEREDITARY, IDVegfc
Lymphoblastic Leukemia, Acute, with Lymphomatous FeaturesJak1
LymphomaCdkn2a , Kras , Pten , Rac2 , Rela , Tp53
Lymphoma, B-Cell, Marginal ZoneTp53
Lymphoma, Large B-Cell, DiffuseCdkn2a , Gli1 , Pik3ca , Pik3cb , Pik3cd
Lymphoma, Large-Cell, AnaplasticStat3
Lymphoma, Mantle-CellCcnd1 , Pik3cd
Lymphoma, Non-HodgkinBraf , Ccnd1 , Map2k1 , Pik3ca , Tp53
Lymphoma, T-CellAkt1 , Arid1a , Stat3 , Tp53
Lymphoma, T-Cell, CutaneousArid1a , Braf , Cdkn2a , Tp53
Lymphoproliferative DisordersStat3
Macrocephaly Autism SyndromePten
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
Macular DegenerationBad , Vegfa
Macular EdemaVegfa
Malformations of Cortical DevelopmentAkt3 , Pik3ca
Mammary Neoplasms, AnimalCcnd1 , Cdc42 , Cdk4 , Egfr , Erbb2 , Pik3r1 , Rb1 , Stat3
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Bcl2l1 , Casp9 , Ccnd1 , Cdc42 , Cdk4 , Cdk6 , Cdkn2a , Egfr , Erbb2 , Ilk , Pik3r1 , Pten , Rb1 , Rela , Stat1 , Stat3 , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa
Mandibular NeoplasmsBraf
Marfan SyndromeTgfbr2
Marijuana AbuseAkt1
MastoiditisRela
Median NeuropathyErbb2
MedulloblastomaBrca2 , Cdk6 , Erbb2 , Pik3ca , Rb1 , Stat3 , Tp53
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3 , Gli3 , Pten
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
MelanomaAkt1 , Bcl2l1 , Braf , Brca2 , Cdk4 , Cdkn2a , E2f1 , Erbb2 , Kras , Map2k1 , Nfkb1 , Pik3ca , Pik3r1 , Pten , Rac1 , Rac2 , Raf1 , Tp53 , Vegfa , Vegfc
Melanoma Astrocytoma SyndromeCdkn2a
Melanoma, Cutaneous MalignantBrca2 , Cdk4 , Cdkn2a , Stat3
Melanoma, Cutaneous Malignant, Susceptibility To, 1Akt1 , Braf , Brca2 , Cdk4 , Cdkn2a , Map2k1 , Pik3ca , Pten , Rac1 , Raf1 , Tp53
Melanoma, Cutaneous Malignant, Susceptibility To, 2Cdkn2a
Melanoma, Cutaneous Malignant, Susceptibility to, 3Cdk4
Melanoma, ExperimentalIkbkb
Melanoma-Pancreatic Cancer SyndromeCdkn2a
Memory DisordersStat3 , Vegfa
Meningeal NeoplasmsAkt1
MeningiomaAkt1 , Pten
Meningioma, FamilialPten
Meningitis, PneumococcalRela
Mental Retardation, Autosomal Dominant 12Arid1b
Mental Retardation, Autosomal Dominant 14Arid1a
Mental Retardation, Autosomal Dominant 16Smarca4
Mental Retardation, X-LinkedArhgef6
Mental Retardation, X-Linked 46Arhgef6
Mental Retardation, X-Linked NonsyndromicArhgef6
MesotheliomaCdkn2a , Egfr , Tp53
Mesothelioma, MalignantCdk6 , Cdkn2a , Egfr , Ilk , Met , Raf1 , Tgfb2 , Tp53
Metabolic Syndrome XTgfb1 , Vegfa
MetaplasiaEgf
MicrocephalyArid1b
MICROCEPHALY AND CHORIORETINOPATHY, AUTOSOMAL RECESSIVE, 2Cdk6
Micronuclei, Chromosome-DefectiveCdkn2a , Rad51
Microphthalmia, Cataracts, and Iris AbnormalitiesSmad4
Microphthalmia, Isolated, with Coloboma 5Shh
Microsatellite InstabilityArid1a , Braf , Tgfbr2
Microvascular Complications of Diabetes, Susceptibility To, 1Vegfa
Microvascular Complications of Diabetes, Susceptibility To, 2Vegfa
Microvascular Complications of Diabetes, Susceptibility To, 7Vegfa
Migraine DisordersTgfbr2
Mirror Movements 2Rad51
Mixed Tumor, MullerianCdkn2a
Mood DisordersAkt1
Motor Skills DisordersPten
Mouth NeoplasmsCdkn2a , Erbb2 , Kras , Pik3ca , Tp53
Mucocutaneous Lymph Node SyndromeVegfa
MucositisTgfa
Multiple MyelomaBcl2l1 , Braf , Ccnd1 , Cdk4 , Cdkn2a , Kras , Met , Pik3ca , Tgfb1 , Tp53 , Vegfa
Multiple Organ FailureMapk1
Multiple SclerosisGli1 , Shh , Vegfa
Multiple Sclerosis, Chronic ProgressiveShh
Muscular AtrophyAkt1 , Chuk , Ikbkb
Muscular DiseasesSmad4 , Tgfb1
Muscular DystrophiesPten
Muscular Dystrophy, DuchenneTgfb1
Musculoskeletal AbnormalitiesTgfb2
Mycobacterial and Viral Infections, Susceptibility To, Autosomal RecessiveStat1
Mycobacterium InfectionsStat1
Mycobacterium Infections, NontuberculousStat1
Myelodysplastic SyndromesCdkn2a , Kras , Tp53
Myeloproliferative DisordersKras
Myocardial InfarctionAkt1 , Bcl2l1 , Mapk1 , Pgf , Shh , Smad2 , Smad4 , Tgfb1 , Tgfb2 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa , Vegfb
Myocardial IschemiaCcnd1 , Erbb2 , Pgf , Ralbp1 , Vegfa
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Bcl2l1 , Casp9 , Mapk1 , Mapk8 , Mapk9 , Pten , Rela , Shh , Smad3 , Smad4 , Stat1 , Stat3 , Tgfb1 , Tp53 , Vegfa
Nasal PolypsMet , Stat3 , Tgfb1 , Vegfa
Nasopharyngeal carcinomaAkt2 , Arid1a , Ccnd1 , Cdkn2a , Erbb2 , Kras , Pik3ca , Pten , Tp53
Nasopharyngeal NeoplasmsCcnd1 , Egfr , Pik3ca , Tp53
NecrosisCdc42
Nematode InfectionsPik3r1
Neoplasm InvasivenessCdkn2a , Egf , Egfr , Mapk1 , Mapk3 , Met , Pten , Rela , Tgfb1
Neoplasm MetastasisAkt2 , Braf , Cdkn2a , Egf , Egfr , Erbb2 , Kras , Mapk1 , Mapk3 , Mapk9 , Met , Pten , Rac1 , Rb1 , Stat3 , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa
Neoplasm Recurrence, LocalEgfr , Erbb2 , Vegfa
NeoplasmsBraf , Cdkn2a , Erbb2 , Kras , Map2k1 , Met , Pik3ca , Pik3r1 , Pten , Rb1 , Tp53 , Vegfa
Neoplasms, Cystic, Mucinous, and SerousMet
Neoplasms, ExperimentalCcnd1 , Cdk4 , Erbb2 , Kras , Rb1 , Rela , Tp53 , Vegfa
Neoplasms, Germ Cell and EmbryonalCdk4 , Cdkn2a , Erbb2
Neoplasms, Plasma CellBcl2l1
Neoplasms, Squamous CellBrca2
Neoplastic Syndromes, HereditaryBrca2 , Cdk4 , Cdkn2a , Met , Pik3ca , Pten , Smad4 , Tp53
Neovascularization, PathologicVegfa
NephritisItga4
Nephrolithiasis, Calcium OxalateTgfb1
NephrosisLrp2
Nephrotic SyndromeTgfb1
Nerve DegenerationMapk1 , Mapk3 , Tgfa , Vegfa
Nerve Sheath NeoplasmsCdkn2a , Met , Pten , Tp53
Nervous System DiseasesCasp9 , Tp53
Neural Tube DefectsGli3
NeuralgiaTgfb1
NeurilemmomaCdkn2a
NeuroblastomaArid1a , Arid1b , Cdkn2a , Kras , Met , Pik3ca , Tp53
Neurodevelopmental DisordersArid1b , Pten , Tcf7l2
Neuroendocrine TumorsBraf
Neurofibromatosis 1Vegfa
Neurofibromatosis 2Vegfa
NeurofibrosarcomaVegfa
Neuroma, AcousticVegfa
Neurotoxicity SyndromesBcl2l1
Neutrophil Immunodeficiency SyndromeRac2
NevusBraf
Nevus, Sebaceous of JadassohnKras
Nicolaides Baraitser SyndromeArid1b
Niemann-Pick Disease, Type CStat3
Non-alcoholic Fatty Liver DiseaseIkbkg , Stat3 , Tgfb1
Nonseminomatous Germ Cell TumorBraf
Nonsyndromic DeafnessMet
Noonan SyndromeBraf , Kras , Map2k1 , Raf1
Noonan syndrome 3Kras
Noonan Syndrome 5Raf1
Noonan Syndrome 7Braf
Nose NeoplasmsTp53
ObesityAkt1 , Akt2 , Bad , Cdk4 , Cdkn2a , Egfr , Ikbkb , Pgf , Pik3r1 , Rb1 , Rela , Smarca4 , Stat3 , Tgfb1
Occupational DiseasesTgfb1
Ocular HypertensionBcl2l1 , Gli1 , Shh
Odontogenic CystsSmad4
Odontogenic MyxomaTp53
Optic Atrophy, Hereditary, LeberTp53
Oral Squamous Cell CarcinomaMet
Oral Submucous FibrosisTgfb1 , Tp53
Oropharyngeal NeoplasmsTp53
Ossification, HeterotopicSmad4
OsteoarthritisBad , Cdkn2a , Smad3
Osteoarthritis, KneeTgfa
OsteochondrodysplasiasPten , Tgfb1 , Tgfb2 , Tgfbr1 , Vegfa
Osteofibrous DysplasiaMet
OsteoporosisTgfb1
Osteoporosis, PostmenopausalTgfb1
OsteosarcomaAkt1 , Brca2 , Egfr , Met , Rb1 , Tp53 , Vegfa
Otitis MediaRela , Vegfa
Otitis Media with EffusionVegfa
Ovarian CystsNfkb1
Ovarian Epithelial CancerPik3ca , Tp53
Ovarian NeoplasmsAkt1 , Akt2 , Bcl2l1 , Braf , Brca2 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3r1 , Pten , Rad51 , Rb1 , Rela , Smad2 , Smad4 , Smarca4 , Stat3 , Tp53 , Vegfa , Vegfc , Vegfd
Oxygen-Induced RetinopathyMapk8 , Stat3 , Vegfa
Paget's Disease, MammaryErbb2
PainAkt1
Pallister-Hall SyndromeGli3
Pancreatic AdenocarcinomaCdkn2a , Erbb2 , Kras , Pik3ca , Smad4 , Tp53
Pancreatic CarcinomaCdkn2a , Kras , Smad4 , Tp53
Pancreatic NeoplasmsAkt2 , Arid1a , Arid1b , Bcl2l1 , Boc , Brca2 , Cdkn2a , Egf , Egfr , Gli1 , Gli3 , Ilk , Itga11 , Itga4 , Itga9 , Kras , Lrp2 , Met , Pbrm1 , Pten , Rad51 , Rb1 , Rela , Shh , Smad3 , Smad4 , Smarca4 , Stat3 , Tcf7l2 , Tgfa , Tgfb1 , Tgfbr2 , Tp53 , Vegfb , Wnt9a
PancreatitisEgf , Ikbkb , Met
Pancreatitis, Acute NecrotizingRela
Pancreatitis, ChronicBad
Pancreatitis, ExperimentalIkbkg
Pancreatitis, Experimental, Acute Bcl2l1 , Kras
Pancreatitis, Experimental, Chronic Gli1
Papillary Renal Cell Carcinoma, SporadicBraf , Cdkn2a , Erbb2 , Pik3ca , Tp53
PapillomaCcnd1 , Egfr , Erbb2 , Tgfb1
Papilloma, Choroid PlexusTp53
Papilloma, InvertedVegfa
Papillomavirus InfectionsCdkn2a
Paranasal Sinus NeoplasmsTp53
ParaplegiaAkt1
Paraquat LungTgfb1
Parkinson DiseaseAkt1 , Egf , Egfr , Erbb2
Parkinson Disease, SecondaryShh
Parkinsonian DisordersBad , Egfr , Rela , Shh
Patterson Stevenson SyndromeShh
Pemphigoid, BullousVegfa
Penile IndurationTgfb1
Penile NeoplasmsCcnd1 , Kras , Pik3ca , Tp53
Periodontal AtrophyVegfa
PeriodontitisMet
Peripheral Nerve InjuriesShh
Peripheral Nervous System DiseasesCasp9 , Cdkn2a , Gli1
Peripheral Nervous System NeoplasmsPten
Peritoneal FibrosisTgfb1
Persistent CloacaShh
Persistent Hyperplastic Primary VitreousCdkn2a
Phyllodes TumorEgfr , Rb1 , Tp53
PiebaldismGli3
Pituitary Dwarfism 1Brca2
Pituitary NeoplasmsRb1
PlasmacytomaCdkn2a
Pleomorphic Xanthoastrocytoma Braf , Cdk6 , Egfr , Gli3 , Met , Rala
Pleural DiseasesTgfb1
PneumoniaEgf , Ikbkb , Itga4 , Tgfb1
Pneumonia, BacterialChuk , Pgf , Stat3
Pneumonia, PneumococcalMapk1 , Mapk3
PoisoningCdkn2a
Polyarteritis NodosaVegfa
Polycystic Kidney, Autosomal DominantLrp2
Polycystic Kidney, Autosomal RecessiveAkt1 , Egfr , Pik3ca
Polycystic Ovary SyndromeVegfa
Polycythemia VeraBcl2l1 , Jak1
PolydactylyGli3 , Pten , Shh
Polydactyly, PostaxialGli3
Polydactyly, Preaxial 4Gli3
Polydactyly, Preaxial IIShh
PolymicrogyriaAkt3
PolyploidyTp53
Polypoidal Choroidal VasculopathyVegfa
Pre-EclampsiaErbb2 , Itga4 , Pgf , Vegfa
Precancerous ConditionsCcnd1 , Cdkn2a , Egf , Mapk8 , Mapk9 , Smad3 , Smad4 , Stat3 , Tp53 , Vegfa
Precursor B-Cell Lymphoblastic Leukemia-LymphomaBcl2l1 , Ccnd1 , Cdkn2a , Stat3 , Tp53
Precursor Cell Lymphoblastic Leukemia-LymphomaBcl2l1 , Ccnd1 , Cdk6 , Cdkn2a , Kras , Rb1 , Tp53
Precursor T-Cell Lymphoblastic Leukemia-LymphomaCdkn2a , Kras , Stat1
Pregnancy in DiabeticsVegfa
Premature BirthPgf
Pressure UlcerVegfa
PRIMARY AUTOSOMAL RECESSIVE MICROCEPHALY 12Cdk6
Primary MyelofibrosisTgfb1 , Tp53
ProlactinomaLrp2
Prostate Cancer, SomaticPten
Prostatic HyperplasiaBad , Cdk4 , Pten , Rela
Prostatic Intraepithelial NeoplasiaCcnd1 , Kras , Pten , Rela , Smad4
Prostatic NeoplasmsAkt1 , Bad , Bcl2l1 , Braf , Brca2 , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , Chuk , E2f1 , Egf , Egfr , Erbb2 , Gli1 , Ilk , Kras , Lrp2 , Map2k1 , Mapk10 , Mapk3 , Met , Pik3ca , Pik3cd , Pik3r1 , Pten , Rac2 , Ralbp1 , Rb1 , Rela , Smad3 , Smad4 , Smarca4 , Stat1 , Stat3 , Tgfa , Tgfb1 , Tgfbr2 , Tp53 , Vegfa
ProstatitisSmad4
ProteinuriaTgfb1 , Vegfa
Proteus SyndromeAkt1 , Pten
Pseudoxanthoma ElasticumVegfa
PsoriasisIkbkb , Stat3 , Tgfa , Tgfb1 , Tp53 , Vegfa
Psychoses, Substance-InducedAkt1
Pten Hamartoma Tumor Syndrome with Granular Cell TumorPten
PterygiumTp53 , Vegfa , Vegfc
Pulmonary Disease, Chronic ObstructiveBcl2l1 , Egfr , Mapk8 , Smad4 , Tgfb1 , Tp53 , Vegfa
Pulmonary EdemaTgfa , Vegfa
Pulmonary EmphysemaPgf , Tgfb1
Pulmonary FibrosisBad , Egf , Egfr , Smad4 , Stat1 , Stat3 , Tgfa , Tgfb1 , Tgfbr2
Purpura, Thrombocytopenic, IdiopathicTgfb1
PyelonephritisPgf
Radiation InjuriesTgfbr2
Radiation Injuries, ExperimentalMapk1 , Mapk3
Radiation PneumonitisTgfb1
RASopathiesBraf , Kras , Map2k1 , Raf1
Rectal NeoplasmsEgfr , Pik3ca
RecurrenceErbb2 , Kras , Vegfc
Renal FibrosisKras , Mapk1
Renal Insufficiency, ChronicShh
Reoviridae InfectionsStat1
Reperfusion InjuryAkt1 , Bad , Casp9 , Ccnd1 , Cdc42 , Egf , Mapk8 , Mapk9 , Met , Pik3r1 , Pten , Rela , Stat1 , Stat3 , Tgfbr2 , Tp53 , Vegfc , Vegfd
Respiratory System AbnormalitiesTgfb2 , Tgfb3
Retina Reperfusion InjuryBad , Bcl2l1 , Stat3 , Vegfa
Retinal DetachmentCasp9
Retinal DiseasesVegfa
Retinal NeovascularizationVegfa , Vegfb
Retinal TelangiectasisVegfa
Retinal Vein OcclusionVegfa , Vegfb
Retinitis PigmentosaItga4 , Pten , Vegfa
RetinoblastomaRb1
Retinopathy of PrematurityVegfa
Rhabdoid Tumor Predisposition Syndrome 2Smarca4
RhabdomyosarcomaBrca2 , Cdkn2a , Tp53 , Vegfa
RhinitisCdc42 , Tgfb1 , Vegfa
Rhinitis, Allergic, SeasonalVegfa
Salivary Gland NeoplasmsCcnd1
SarcoidosisTgfb1
Sarcoidosis, PulmonaryTgfb1
SarcomaMet , Pik3ca , Smarca4 , Tp53
Sarcoma Family Syndrome of Li and FraumeniCdkn2a , Tp53
Sarcoma, ExperimentalKras
Sarcoma, KaposiTp53
Sarcoma, MyeloidKras
SchizencephalyShh
SchizophreniaAkt1 , Egf , Egfr , Mapk3 , Met , Pik3cb , Tp53
Schizophrenia, ChildhoodRela
Scleroderma, LimitedPgf
Scleroderma, LocalizedTgfb1
Scleroderma, SystemicVegfa
ScrapieStat1 , Stat3
Sebaceous Nevus Syndrome and HemimegalencephalyKras
SeizuresArid1b , Bad , Ccnd1 , Pld1 , Pten
SeminomaKras , Rb1 , Smad4 , Vegfa
Senior Loken SyndromeAkt3
SepsisBad , Mapk1 , Mapk3 , Pgf , Rela , Stat1 , Stat3 , Tgfb1
Sepsis-Associated EncephalopathyStat3
Septic PeritonitisPik3r1
Sezary SyndromeArid1a , Braf , Cdkn2a , Mapk1 , Pten , Rb1 , Smarca4 , Tp53
Shock, HemorrhagicBad , Bcl2l1 , Mapk1 , Rela
SHORT SyndromePik3r1
Single Upper Central IncisorShh
SinusitisMet
Sjogren's SyndromeTgfb1
Skin AbnormalitiesChuk
Skin DiseasesPten
Skin NeoplasmsAkt1 , Rela , Stat3 , Tgfb1 , Tgfbr1 , Tp53 , Vegfa
Sleep Apnea, ObstructiveRela
Small Cell Lung CarcinomaAkt1 , Egfr , Pik3ca , Pten , Rb1 , Smarca4 , Tp53
Small-For-Size SyndromeBad , Vegfa
Smith-Magenis SyndromeErbb2 , Stat3
Spina Bifida CysticaActl6a
Spinal Cord InjuriesAkt1 , Brca2 , Cdc42 , Egfr , Met , Rela , Shh , Tgfb1 , Tgfb2 , Tp53 , Vegfa
Spinal Cord Reperfusion InjuryBad
Spinal DysraphismGli1
SplenomegalyKras
Spondylitis, AnkylosingPgf
Spondylocostal Dysostosis 5Mapk3
Squamous Cell Carcinoma of the LungAkt1 , Braf , Cdkn2a , Egfr , Kras , Pik3ca , Pten , Tp53
Squamous Cell Carcinoma of the TongueEgfr , Met , Tp53
Status EpilepticusBcl2l1 , Ccnd1 , Pgf , Rela , Vegfa
Stevens-Johnson SyndromeRb1
Still's Disease, Adult-OnsetVegfa
Stomach DiseasesPten
Stomach NeoplasmsArid1a , Bcl2l1 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Gli3 , Kras , Mapk1 , Mapk3 , Mapk8 , Met , Pik3ca , Smad4 , Stat3 , Tgfa , Tp53
Stomach UlcerBad , Bcl2l1 , Egf , Vegfa
StrokeAkt1 , Bcl2l1 , Mapk8 , Pgf , Tgfa , Tgfb1 , Vegfa
Subarachnoid HemorrhageGli1 , Shh , Stat3
Substance Withdrawal SyndromeMapk1 , Mapk3
Substance-Related DisordersPten
Sudden Infant DeathVegfa
SyndactylyGli3
Syndactyly, Type IVShh
SyndromeRac2
Tachycardia, VentricularRaf1
Takenouchi-Kosaki SyndromeCdc42
Telangiectasia, Hereditary HemorrhagicSmad4
Telangiectasia, Hereditary Hemorrhagic, Type 1Tgfb1
Thoracic DiseasesIlk
Thoracic NeoplasmsSmarca4
Thrombocythemia, EssentialTgfb1
ThrombocytopeniaTgfb1
ThrombosisPik3cb
Thrombotic MicroangiopathiesVegfa
ThymomaCdkn2a , Pbrm1 , Tp53
Thymus NeoplasmsTp53
Thyroid Cancer, FollicularBraf , Pten
Thyroid Cancer, MedullaryKras
Thyroid cancer, papillaryBraf
Thyroid Carcinoma, AnaplasticTp53
Thyroid NeoplasmsBraf , Ccnd1 , Kras , Pten , Tp53
Thyroiditis, AutoimmuneLrp2
Tibial FracturesPgf
Tobacco Use DisorderEgfr
Tongue NeoplasmsCdkn2a , Stat3 , Tp53 , Vegfa , Vegfc
Tracheal StenosisTgfb1
Translocation, GeneticCdkn2a
Transplant RejectionIkbkb , Itga4
Trauma, Nervous SystemStat1
Trigeminal Nerve InjuriesTp53
Trigeminal NeuralgiaMapk1 , Mapk3 , Mapk8 , Mapk9
TrisomyCdkn2a
Tumor Predisposition SyndromeBrca2 , Cdk4 , Cdkn2a , Met , Pten , Smad4 , Tp53
Tympanic Membrane PerforationVegfa
UremiaTgfb1 , Tgfbr1
Ureteral ObstructionAkt1 , Shh , Tgfb1 , Tgfb2
Urethral ObstructionMapk1 , Tgfb1
Urinary Bladder NeoplasmsAkt1 , Arid1a , Bcl2l1 , Casp9 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Gli1 , Kras , Pten , Ralbp1 , Rb1 , Rela , Smad2 , Smad4 , Tgfbr1 , Tp53 , Vegfc , Vegfd
Urinary IncontinenceMapk1
Urogenital AbnormalitiesTgfb2
Urogenital NeoplasmsCdkn2a , Tp53
Urologic NeoplasmsCcnd1 , Erbb2 , Tp53 , Vegfa
UrticariaTgfb1
Uterine Cervical NeoplasmsAkt1 , Bcl2l1 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Kras , Mapk1 , Pik3ca , Pten , Rela , Smad2 , Smad4 , Stat3 , Tp53 , Vegfa
Uterine NeoplasmsBcl2l1 , Brca2 , Kras , Smad3
Uveal MelanomaBrca2 , Vegfa
UveitisRela , Tgfb1
Uveitis, Autoimmune, ExperimentalStat3
Uveoretinitis, Autoimmune, ExperimentalStat3
VACTERL/VATER AssociationShh
VACTERL/VATER Association with HydrocephalusPten
VaricoceleCasp9
Ventilator-Induced Lung InjuryAkt1
Ventricular Premature ComplexesTgfb3
Ventricular RemodelingSmad2 , Smad3 , Tgfb1
Vitamin D DeficiencyLrp2
VitiligoTgfb1
von Hippel-Lindau DiseaseCcnd1
Vulvar Lichen SclerosusCdkn2a , Tp53
Vulvar NeoplasmsCdkn2a , Tp53
Wallerian DegenerationErbb2 , Pgf , Tgfb1 , Tgfb2
Weight GainPik3ca
Wet Macular DegenerationMapk8 , Vegfa
Wilms TumorBcl2l1 , Brca2 , Cdk4 , Cdkn2a , Erbb2 , Stat1 , Stat3 , Vegfc
Woolly Hair, Autosomal RecessiveRb1
Wounds and InjuriesEgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa
Wounds, PenetratingPgf
Xeroderma PigmentosumTp53
Zollinger-Ellison SyndromeEgf
Pathway Annotations Associated with Genes in the pancreatic cancer pathway
Pathway TermsGene Symbols
activin signaling pathwaySmad2 , Smad3
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Stat3 , Tcf7l2
adenosine signaling pathwayAkt1 , Bad , Braf , Cdc42 , Chuk , Ikbkb , Mapk1 , Mapk8 , Nfkb1 , Pik3ca
aldosterone signaling pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2 , Tgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered G1/S transition pathwayCdkn2a
altered Hedgehog signaling pathwayBoc , Gli1 , Gli3 , Lrp2 , Shh
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered integrin mediated signaling pathwayIlk , Itga11 , Itga4 , Itga9
altered p53 signaling pathwayTp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered scatter factor/hepatocyte growth factor signaling pathwayMet
altered SWI/SNF family mediated chromatin remodeling pathwayActl6a , Arid1a , Arid1b , Pbrm1 , Smarca4
altered transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expressionVegfa
altered vascular endothelial growth factor signaling pathway involving the main playersVegfa
altered Wnt signaling, canonical pathwayTcf7l2 , Wnt9a
Alzheimer disease pathwayBad , Casp9 , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBad , Bcl2l1 , Casp9 , Rac1 , Tp53
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2l1 , Casp9 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tp53
Arf family mediated signaling pathwayRac1
arrhythmogenic right ventricular cardiomyopathy pathwayItga11 , Itga4 , Itga9 , Tcf7l2
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Rela
basal cell carcinoma pathwayGli1 , Gli3 , Shh , Tcf7l2 , Tp53 , Wnt9a
bevacizumab pharmacodynamics pathwayVegfa
bladder cancer pathwayBraf , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Pgf , Raf1 , Rb1 , Tp53 , Vegfa , Vegfb , Vegfc , Vegfd
Bone morphogenetic proteins signaling pathwayMapk1 , Smad4
c-Jun N-terminal kinases MAPK signaling pathwayCdc42 , Mapk10 , Mapk8 , Mapk9 , Rac1
calcium/calcium-mediated signaling pathwayEgfr , Erbb2
cell cycle pathway, mitoticCcnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Rb1 , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tp53
cell-extracellular matrix signaling pathwayItga11 , Itga4 , Itga9
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Arhgef6 , Bad , Bcl2l1 , Braf , Brca2 , Casp9 , Ccnd1 , Cdc42 , Cdk4 , Cdk6 , Cdkn2a , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Ikbkb , Ikbkg , Jak1 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Rac2 , Rad51 , Raf1 , Rala , Ralb , Ralbp1 , Ralgds , Rb1 , Rela , Smad2 , Smad3 , Smad4 , Stat1 , Stat3 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa , Vegfb , Vegfc , Vegfd
cetuximab pharmacodynamics pathwayEgfr
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Rela , Stat1 , Stat3
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2l1 , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Chuk , E2f1 , E2f3 , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Rela , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Ralgds , Smad2 , Smad3 , Smad4 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
cortisol signaling pathwaySmarca4
cytokine mediated signaling pathwayEgf , Egfr , Met , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Vegfc , Vegfd
dilated cardiomyopathy pathwayItga11 , Itga4 , Itga9 , Tgfb1 , Tgfb2 , Tgfb3
doxorubicin pharmacokinetics pathwayRalbp1
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Cdc42 , Egf , Egfr , Pik3ca , Pik3r1 , Rac1
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5 , Rac1
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaIlk
endocytosis pathwayCdc42 , Egf , Egfr , Met , Pld1 , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Ilk , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Tcf7l2 , Tp53
Endoplasmic Reticulum-associated degradation pathwayMapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Cdc42 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Rac1 , Raf1
Entamoeba histolyca infection pathwayNfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tgfb1 , Tgfb2 , Tgfb3
ephrin - ephrin receptor bidirectional signaling axisCdc42 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1 , Pik3r5 , Rac1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Stat1 , Stat3 , Tgfa
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayBcl2l1 , Mapk8 , Nfkb1 , Pik3r1 , Stat1
ether lipid metabolic pathwayPld1
ether lipid metabolic pathwayPld1
FasL mediated signaling pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Cdc42 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Rac2 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Stat1
forkhead class A signaling pathwayAkt1 , Shh
G1 phase pathwayCcnd1 , Cdk4
G1/S transition pathwayCcnd1 , Cdk4 , Cdk6 , Cdkn2a , Rb1
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tgfa , Tp53
glutamate signaling pathwayMapk1 , Mapk3 , Pld1
glycerophospholipid metabolic pathwayPld1
glypican signaling pathwayMapk8 , Mapk9 , Shh , Smad2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr2 , Vegfa
gonadotropin-releasing hormone signaling pathwayCdc42 , Egfr , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pld1 , Raf1
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Raf1 , Stat1 , Stat3
Hedgehog signaling pathwayAkt1 , Boc , Gli1 , Gli3 , Lrp2 , Map2k1 , Pik3ca , Pik3r1 , Shh , Tgfb2 , Wnt9a
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Chuk , Egf , Egfr , Ikbkb , Ikbkg , Jak1 , Kras , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Stat1 , Stat3 , Tp53
histone modification pathwayPbrm1 , Smarca4
homologous recombination pathway of double-strand break repairBrca2 , Rad51
Huntington disease pathwayCasp9 , Tp53
hypertrophic cardiomyopathy pathwayItga11 , Itga4 , Itga9 , Tgfb1 , Tgfb2 , Tgfb3
hypoxia inducible factor pathwayAkt1 , Smad3 , Smad4 , Vegfa
inflammatory response pathwayMapk8
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Casp9 , Ikbkb , Jak1 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Stat1
INO80 family mediated chromatin remodeling pathwayActl6a
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Rac1
insulin secretion pathwayCdc42
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ikbkb , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
insulin-like growth factor signaling pathwayAkt1 , Bad , Pik3ca , Pik3r1 , Raf1
integrin mediated signaling pathwayIlk , Itga11 , Itga4 , Itga9
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Rela
Interleukin-10 signaling pathwayJak1 , Stat1 , Stat3
interleukin-12 signaling pathwayNfkb1 , Rela , Stat1 , Stat3
interleukin-2 signaling pathwayJak1 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3r1 , Raf1 , Stat1 , Stat3
interleukin-23 signaling pathwayNfkb1 , Pik3ca , Pik3r1 , Rela , Stat1 , Stat3
interleukin-27 signaling pathwayJak1 , Stat1 , Stat3 , Tgfb1
interleukin-3 signaling pathwayBcl2l1 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Jak1 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Jak1 , Pik3ca , Pik3r1 , Rac1 , Stat1 , Stat3
intrinsic apoptotic pathwayBad , Bcl2l1 , Casp9
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Ccnd1 , Jak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3
Leishmania infection pathwayItga4 , Jak1 , Mapk1 , Mapk3 , Nfkb1 , Rela , Stat1 , Tgfb1 , Tgfb2 , Tgfb3
leptin system pathwayStat3
long term depressionBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
long term potentiationBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
measles infection pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Cdk4 , Cdk6 , Chuk , Jak1 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Stat3 , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tp53
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Chuk , Egf , Egfr , Erbb2 , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Rac1 , Rac2 , Raf1 , Rela , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Ikbkb , Map2k1 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Jak1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Raf1 , Rela , Stat1 , Tgfb1 , Tgfb2 , Tgfb3
myocarditis pathwayCasp9 , Ccnd1 , Rac1 , Rac2
N-cadherin signaling pathwayCdc42 , Mapk8 , Pik3ca , Pik3r1 , Rac1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdc42 , Ikbkb , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rela , Tp53
NOD-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Rela
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tgfa , Tp53
Non-Stat, Jak dependent pathwayJak1
Notch signaling pathwayCcnd1
nuclear factor kappa B signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb , Pten
p38 MAPK signaling pathwayCdc42 , Rac1
p53 signaling pathwayAkt1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Mapk8 , Mapk9 , Pten , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayActl6a , Akt1 , Akt2 , Akt3 , Arhgef6 , Arid1a , Arid1b , Bad , Bcl2l1 , Boc , Braf , Brca2 , Casp9 , Ccnd1 , Cdc42 , Cdk4 , Cdk6 , Cdkn2a , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Gli1 , Gli3 , Ikbkb , Ikbkg , Ilk , Itga11 , Itga4 , Itga9 , Jak1 , Kras , Lrp2 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Met , Nfkb1 , Pbrm1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Pten , Rac1 , Rac2 , Rad51 , Raf1 , Rala , Ralb , Ralbp1 , Ralgds , Rb1 , Rela , Shh , Smad2 , Smad3 , Smad4 , Smarca4 , Stat1 , Stat3 , Tcf7l2 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa , Vegfb , Vegfc , Vegfd , Wnt9a
panitumumab pharmacodynamics pathwayEgfr
Parkinson disease pathwayCasp9
phagocytosis pathwayRac1
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rac1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1 , Pten
Plasmodium infection pathwayMet , Tgfb1 , Tgfb2 , Tgfb3
platelet-derived growth factor signaling pathwayBraf , Jak1 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rac1 , Raf1 , Stat1 , Stat3
primary immunodeficiency disease pathwayIkbkg
prion diseases pathwayMap2k1 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Rela , Tcf7l2 , Tgfa , Tp53
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Mapk8 , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pbrm1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb , Vegfc , Vegfd
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk10 , Mapk8 , Mapk9 , Nfkb1 , Rela
rheumatoid arthritis disease pathwayPgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb
Rho/Rac/Cdc42 mediated signaling pathwayCdc42 , Mapk8 , Rac1
RNA polymerase III transcription pathwayRb1
S phase pathwayCcnd1 , Cdk4
scatter factor/hepatocyte growth factor signaling pathwayMet , Pik3r1
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Chuk , E2f1 , E2f3 , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rb1 , Rela , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Cdc42 , Mapk1 , Mapk3 , Mapk8 , Rac1 , Vegfa
SWI/SNF family mediated chromatin remodeling pathwayActl6a , Arid1a , Arid1b , Pbrm1 , Smarca4
syndecan signaling pathwayEgfr , Mapk1 , Mapk3 , Mapk8 , Rac1 , Tgfb1
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cdc42 , Cdk4 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Tcf7l2 , Tp53
tioguanine pharmacodynamics pathwayRac1
titanium dioxide nanoparticle response pathwayTp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Stat1
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2l1 , Casp9 , Chuk , Ikbkb , Ikbkg , Jak1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Stat3 , Tgfb1 , Tgfb2 , Tgfb3
Trail mediated signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
trastuzumab pharmacodynamics pathwayEgfr
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
tumor necrosis factor mediated signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela , Stat1
type 2 diabetes mellitus pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Jak1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Stat1 , Stat3
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Cdc42 , Kras , Map2k1 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
vinblastine pharmacodynamics pathwayRalbp1 , Tp53
vincristine pharmacodynamics pathwayRalbp1 , Tp53
vindesine pharmacodynamics pathwayRalbp1 , Tp53
vinorelbine pharmacodynamics pathwayRalbp1 , Tp53
Wnt signaling pathwayCcnd1 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Rac2 , Smad2 , Smad3 , Smad4 , Tcf7l2 , Tp53 , Wnt9a
Wnt signaling, canonical pathwaySmarca4 , Tcf7l2 , Wnt9a
Wnt signaling, non-canonical pathwayCdc42 , Mapk10 , Mapk8 , Mapk9 , Rac1
Wnt signaling, the planar cell polarity pathwayRac1
Phenotype Annotations Associated with Genes in the pancreatic cancer pathway

References Associated with the pancreatic cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: