PANCREATIC CANCER PATHWAY (PW:0000626)

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Description

Pancreatic cancer is the fourth leading cause of cancer-related deaths. It equally affects both men and women and continues to have a very low overall 5-year survival rate of less than 5%. Pancreatic ductal adenocarcinoma (PDAC) is the predominant form with several precursor lesions such as pancreatic intraepithelial neoplasia (PanIN) graded stage I to III. Other lesions include the intraductal papillary mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN). The driver oncogene is believe

Pathway Diagram:

Elsevier Inc. Smarca4 Arid1a Arid1b Pbrm1 Actl6a altered SWI/SNF family mediated chromatin remodeling pathway ---> genome instability altered p53 signaling pathway ---> altered cellular events altered cellular events altered p53 signaling pathway altered p53 signaling pathway ---> altered expression of target genes altered p53 signaling pathway ---> genome instability genome instability Ilk Itga4 altered integrin mediated signaling pathway ---> altered cellular events altered Wnt signaling, canonical pathway ---> altered expression of target genes altered transforming growth factor-beta Smad dependent signaling pathway ---> altered expression of target genes altered integrin mediated signaling pathway altered G1/S transition pathway ---> genome instability altered expression of target genes altered Wnt signaling, canonical pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes altered Hedgehog signaling pathway ---> altered expression of target genes downregulated miRNA ---> upregulated target translation Tp53 Kras Pten Tcf7l2 Smad3 Smad4 Tgfbr2 Lrp2 Gli3 Gli1 Shh Boc Cdkn2a upregulated miRNA ---> downregulated target translation Pancreatic Neoplasms Egfr altered regulation of target genes altered epidermal growth factor/neuregulin signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway altered epidermal growth factor/neuregulin signaling pathway Tgfa Egf altered extracellular signal-regulated Raf/Mek/Erk signaling pathway Akt2 altered scatter factor/hepatocyte growth factor signaling pathway altered transforming growth factor-beta Smad dependent signaling pathway Wnt9a upregulated target translation potential pancreatic cancer miRNA altered SWI/SNF family mediated chromatin remodeling pathway altered G1/S transition pathway Itga9 altered scatter factor/hepatocyte growth factor signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway altered scatter factor/hepatocyte growth factor signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered epidermal growth factor/neuregulin signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway Met altered Hedgehog signaling pathway Itga11 downregulated target translation upregulated miRNA downregulated miRNA altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered Hedgehog signaling pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered regulation of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered regulation of target genes potential pancreatic cancer miRNA ---> Pancreatic Neoplasms
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Genes in Pathway:

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pancreatic cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actl6a actin-like 6A JBrowse link 2 119,112,776 119,128,870 RGD:8694154
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:5490965
RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 JBrowse link X 159,722,031 159,841,344 RGD:6907045
G Arid1a AT-rich interaction domain 1A JBrowse link 5 151,904,687 151,977,973 RGD:8694154
G Arid1b AT-rich interaction domain 1B JBrowse link 1 45,923,119 46,232,301 RGD:8694154
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6907045
G Boc BOC cell adhesion associated, oncogene regulated JBrowse link 11 61,084,216 61,159,220 RGD:5490966
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6907045
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6907045
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6907045
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:5490966
RGD:6907045
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6907045
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6907045
G E2f3 E2F transcription factor 3 JBrowse link 17 36,334,136 36,408,831 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:5490965
RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:5490965
RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:6907045
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:5490966
RGD:5491005
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:5490966
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6907045
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:5490966
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,874 67,683,973 RGD:5490966
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:5490966
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,271,029 127,576,709 RGD:5490966
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:5490965
RGD:5490966
RGD:6907045
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:5490966
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:5490965
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6907045
G Pbrm1 polybromo 1 JBrowse link 16 7,103,714 7,202,899 RGD:8694154
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pld1 phospholipase D1 JBrowse link 2 113,651,967 113,849,403 RGD:6907045
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:5490965
G Rac1 ras-related C3 botulinum toxin substrate 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) JBrowse link 7 119,769,708 119,797,111 RGD:6907045
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rala RAS like proto-oncogene A JBrowse link 17 49,676,073 49,729,133 RGD:6907045
G Ralb RAS like proto-oncogene B JBrowse link 13 35,494,716 35,531,503 RGD:6907045
G Ralbp1 ralA binding protein 1 JBrowse link 9 113,579,107 113,598,477 RGD:6907045
G Ralgds ral guanine nucleotide dissociation stimulator JBrowse link 3 7,090,134 7,130,548 RGD:6907045
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6907045
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6907045
G Shh sonic hedgehog JBrowse link 4 718,538 727,691 RGD:5490965
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:6907045
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:5490966
RGD:6907045
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:5490965
RGD:5490966
RGD:6907045
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 8 22,648,323 22,739,468 RGD:8694154
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6907045
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6907045
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:5490966
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:5490965
RGD:6907045
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6907045
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6907045
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:6907045
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:5490965
RGD:5490966
RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:5490966
RGD:6907045
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6907045
G Vegfb vascular endothelial growth factor B JBrowse link 1 222,237,000 222,242,786 RGD:6907045
G Vegfc vascular endothelial growth factor C JBrowse link 16 40,440,371 40,555,178 RGD:6907045
G Vegfd vascular endothelial growth factor D JBrowse link X 31,816,480 31,852,239 RGD:6907045
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:5490966

Pathway Gene Annotations

Disease Annotations Associated with Genes in the pancreatic cancer pathway
Disease TermsGene Symbols
Abnormalities, MultipleArid1b , Cdc42 , Chuk , Kras , Mapk1 , Pld1 , Pten , Smad2 , Smarca4
Abortion, SpontaneousPgf , Tgfb1 , Tgfbr1
Absence of Tibia with PolydactylyShh
Acro-OsteolysisSmad4
Acromicric DysplasiaSmad2 , Tgfb1
Acute Chest SyndromeVegfa
Acute Kidney InjuryBad , Bcl2l1 , Egf , Egfr , Met , Rb1 , Tgfa , Tgfb1 , Tp53 , Vegfa
Acute Lung InjuryEgfr , Tgfb1 , Vegfa
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
AdenocarcinomaArid1a , Ccnd1 , Cdkn2a , Egf , Egfr , Erbb2 , Kras , Met , Nfkb1 , Pik3ca , Pten , Stat3 , Tcf7l2 , Tgfb1 , Tp53 , Vegfa
Adenocarcinoma of EsophagusArid1a , Cdkn2a , Pik3ca , Smad4 , Tp53
Adenocarcinoma of LungAkt1 , Braf , Cdk4 , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Pik3ca , Raf1 , Smad4 , Tp53
ADENOCARCINOMA OF STOMACHAkt1 , Braf , Cdkn2a , Erbb2 , Kras , Map2k1 , Pik3ca , Pten , Raf1 , Smad4 , Tp53
Adenocarcinoma, Bronchiolo-AlveolarEgfr , Kras , Tp53
Adenocarcinoma, Clear CellTp53
Adenocarcinoma, ColorectalBcl2l1
Adenocarcinoma, FollicularKras
Adenocarcinoma, ProstaticAkt1 , Braf , Cdkn2a , Erbb2 , Map2k1 , Pik3ca , Pten , Smad4 , Tp53
AdenomaBcl2l1 , Kras , Tp53
Adenoma, Liver CellKras , Pten
Adenomatous Polyposis ColiAkt1 , Egfr
Adrenal Gland NeoplasmsCdc42 , Cdkn2a , Rb1 , Tp53
Adrenocortical CarcinomaBraf , Cdkn2a , Egfr , Pik3ca , Rb1 , Tp53
Adrenocortical Carcinoma, HereditaryTp53
Adrenocortical Carcinoma, PediatricTp53
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Aging, PrematureCdkn2a , Tp53
AIDS-Associated NephropathyEgf
AlbuminuriaLrp2
Alveolitis, Extrinsic AllergicVegfa
Alzheimer DiseaseAkt1 , Bad , Bcl2l1 , Cdc42 , E2f1 , Egf , Egfr , Ikbkb , Mapk10 , Mapk8 , Mapk9 , Pik3r1 , Stat3 , Tp53 , Vegfa
AmeloblastomaBraf
Amphetamine-Related DisordersAkt1 , Rela
Amyotrophic Lateral SclerosisAkt1 , Casp9 , Pgf , Tp53 , Vegfa
Amyotrophic Lateral Sclerosis 1Bcl2l1
AnemiaKras
Anemia, AplasticTgfb1
Anemia, Nonspherocytic Hemolytic, due to G6pd DeficiencyIkbkg
Anemia, Sickle CellPgf , Tgfb1
AnetodermaTgfb1
AneurysmSmad3 , Tgfbr2
Aneurysm, DissectingSmad3 , Tgfbr1 , Tgfbr2
Angina, UnstableAkt1
AngiomyolipomaPten , Stat1 , Stat3
AnisometropiaPten
AnodontiaGli3
Anorectal AtresiaGli3 , Shh
AnoxiaPgf , Rad51
Anti-Glomerular Basement Membrane DiseaseItga4 , Mapk8
Aortic AneurysmSmad3 , Tgfbr1 , Tgfbr2
Aortic Aneurysm, AbdominalMapk8
Aortic Aneurysm, Familial Thoracic 1Tgfbr2
Aortic Aneurysm, Familial Thoracic 3Tgfbr2
Aortic Aneurysm, ThoracicSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
Aortic DiseasesSmad4
Aortic Valve InsufficiencyEgfr , Tgfb1 , Tgfb2
Aortic Valve StenosisEgfr
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arrhythmogenic Right Ventricular DysplasiaTgfb3
Arrhythmogenic Right Ventricular Dysplasia, Familial, 1Tgfb3
Arsenic PoisoningTp53
ArteriosclerosisMapk9 , Met , Rela , Tgfb1 , Tgfbr2
Arteriovenous FistulaVegfa
Arthritis, ExperimentalAkt1 , Cdc42 , Cdkn2a , Egfr , Gli1 , Ikbkb , Ikbkg , Itga4 , Pgf , Pik3cd , Shh , Stat1 , Stat3 , Tgfbr2 , Vegfa
Arthritis, JuvenileEgf , Kras , Mapk1 , Smad3 , Stat3 , Tcf7l2
Arthritis, PsoriaticStat3
Arthritis, RheumatoidCdk6 , Pgf , Stat1 , Stat3 , Vegfa
AsthmaChuk , Egfr , Pgf , Pten , Tgfb1 , Vegfa
Asthma, OccupationalTgfb1
AstrocytomaAkt1 , Braf , Kras , Met , Tp53
AtaxiaPten
Ataxia-Oculomotor Apraxia 3Pik3r5
AtherosclerosisAkt1 , Pgf , Stat3 , Vegfa , Vegfc
Atrial FibrillationVegfa
Atrioventricular Septal DefectShh
AtrophyMapk3 , Stat3
Attention Deficit Disorder with HyperactivityVegfa
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
Autism Spectrum DisorderMapk3 , Shh
Autistic DisorderEgf , Itga4 , Met , Pten , Stat3
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1Stat3
Autoimmune DiseasesStat3 , Tgfb2
Autoimmune Lymphoproliferative Syndrome, Type IVKras
Bacterial InfectionsCasp9
Balkan NephropathyTp53
Bardet-Biedl SyndromeAkt3
Barrett EsophagusRela
Basal Cell Nevus SyndromeGli1 , Shh
Behcet SyndromeIkbkg , Stat3 , Tgfb1 , Vegfa
BerylliosisTgfb1
Bile Duct NeoplasmsEgfr , Met
Biliary AtresiaPten , Shh
Bipolar DisorderAkt1 , Cdc42
BlepharophimosisArid1b
BlindnessVegfa
Bone DiseasesTgfbr2
Bone Diseases, DevelopmentalChuk , Tgfb2 , Tp53
Bone Diseases, MetabolicLrp2
Bone Marrow NeoplasmsTp53
Bone NeoplasmsTgfbr2
BrachydactylySmad4
Brachydactyly Type A1Shh
Brain EdemaVegfa
Brain InjuriesAkt1 , Bad , Rela , Stat1 , Stat3 , Vegfa , Vegfb
Brain IschemiaAkt1 , Bad , Bcl2l1 , Casp9 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Nfkb1 , Pgf , Rb1 , Rela , Stat3 , Tgfb1 , Tp53
Brain NeoplasmsCcnd1 , Cdk4 , Cdkn2a , Egfr , Pten , Rela , Tp53 , Vegfa
Brain Stem NeoplasmsCdk4 , Cdk6 , Cdkn2a
Breast AdenocarcinomaAkt1 , Kras , Pik3ca , Tp53
Breast Cancer, FamilialBrca2 , Pik3r3 , Rad51
Breast NeoplasmsAkt1 , Akt2 , Bad , Bcl2l1 , Braf , Brca2 , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , Egf , Egfr , Erbb2 , Ikbkb , Kras , Map2k1 , Mapk1 , Met , Pgf , Pik3ca , Pik3r1 , Pten , Rad51 , Raf1 , Rb1 , Rela , Smad2 , Smad4 , Stat1 , Stat3 , Tgfb1 , Tp53 , Vegfa , Vegfb , Vegfc , Wnt9a
Breast Neoplasms, MaleBrca2
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Brca2
Breast-Ovarian Cancer, Familial, Susceptibility To, 2Brca2
Bronchitis, ChronicVegfa
Burkitt LymphomaArid1a , Pik3r1 , Smarca4
BurnsBad , Ccnd1
CachexiaTgfb1
CalcinosisErbb2 , Tgfb1
Camurati-Engelmann SyndromeTgfb1
Candidiasis, Chronic MucocutaneousStat1
Candidiasis, Familial, 6Stat1
Candidiasis, Familial, 7Stat1
CarcinogenesisBraf , Cdkn2a , Erbb2 , Kras
CarcinomaBcl2l1 , Ccnd1 , Cdc42 , Cdk4 , Egfr , Kras , Met , Pik3r1 , Pten , Rb1 , Stat3 , Tgfb1 , Tgfbr2 , Tp53
Carcinoma in SituAkt1 , Cdkn2a , Pten , Rb1
Carcinoma, Adenoid CysticArid1a , Ccnd1 , Pik3ca , Pten , Tp53
Carcinoma, Basal CellErbb2 , Pik3ca , Rb1 , Shh , Tp53
Carcinoma, Ductal, BreastBrca2 , Cdkn2a , Smad4
Carcinoma, EmbryonalRb1
Carcinoma, EndometrioidAkt1 , Egfr , Erbb2 , Kras , Pik3r2 , Pten
Carcinoma, HepatocellularAkt1 , Akt2 , Arid1a , Arid1b , Bcl2l1 , Braf , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , Egf , Egfr , Gli1 , Kras , Met , Pik3ca , Pten , Rac1 , Rb1 , Shh , Smad2 , Smad4 , Stat1 , Tgfa , Tgfb1 , Tgfbr2 , Tp53
Carcinoma, Intraductal, NoninfiltratingBrca2 , Ccnd1 , Erbb2 , Rb1 , Rela , Tp53 , Vegfa
Carcinoma, Large CellMet
Carcinoma, LobularCcnd1 , Erbb2
Carcinoma, Non-Small-Cell LungAkt1 , Akt2 , Braf , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Met , Pik3ca , Pten , Raf1 , Rb1 , Rela , Stat3 , Tgfa , Tp53 , Vegfa
Carcinoma, Pancreatic DuctalCdkn2a , Egf , Kras , Met , Tgfb1 , Tgfbr2 , Vegfa
Carcinoma, PapillaryVegfc
Carcinoma, Renal CellAkt1 , Bad , Bcl2l1 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Met , Pbrm1 , Pik3ca , Pten , Rb1 , Rela , Smad2 , Smad4 , Stat3 , Tp53 , Vegfa , Vegfc
Carcinoma, Small CellRb1 , Smarca4 , Tp53
Carcinoma, Squamous CellAkt1 , Ccnd1 , Cdkn2a , Egfr , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Stat3 , Tgfb1 , Tp53 , Vegfa
Carcinoma, Squamous Cell of Head and NeckAkt1 , Braf , Cdkn2a , Egfr , Erbb2 , Map2k1 , Mapk1 , Pik3ca , Pten , Rac1 , Smad4 , Stat3 , Tp53
Carcinoma, Transitional CellAkt1 , Arid1a , Bcl2l1 , Braf , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Pik3ca , Pten , Smad4 , Tp53
CarcinosarcomaTgfb1
Cardiac FibrosisTgfb1
Cardiac Valvular Defect, DevelopmentalPld1
Cardiofaciocutaneous SyndromeBraf , Kras , Map2k1
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
CardiomegalyAkt1 , Bad , Egfr , Mapk1 , Mapk8 , Met , Pld1 , Pten , Rac1 , Raf1 , Rb1 , Rela , Stat3 , Tgfb1
CardiomyopathiesAkt1 , Ilk , Kras , Mapk1 , Mapk3 , Rad51 , Stat3 , Tp53 , Vegfa
Cardiomyopathy, DilatedEgfr , Erbb2 , Ilk , Kras , Pgf , Rac1 , Raf1
CARDIOMYOPATHY, DILATED, 1NNRaf1
Cardiomyopathy, HypertrophicIlk , Kras , Raf1 , Tgfb1 , Tp53
Cardiomyopathy, Hypertrophic, FamilialIlk , Kras , Raf1
Cardiovascular AbnormalitiesMap2k1
Carotid Artery DiseasesPgf , Tgfb1 , Tp53
CataractBrca2 , Map2k1 , Pten , Tp53
Cecal NeoplasmsCcnd1 , Kras , Tp53
Cell Transformation, NeoplasticCcnd1 , Egf , Kras , Mapk8 , Nfkb1 , Rac1 , Rela , Stat3 , Tgfb1 , Tp53
Central Nervous System NeoplasmsTp53
Cerebral HemorrhageBcl2l1 , Nfkb1 , Rela , Vegfa
Ceroid Lipofuscinosis, Neuronal, 6Mapk1 , Mapk3
Cervical Intraepithelial NeoplasiaCcnd1 , Cdk4 , Cdkn2a , Pten , Rb1 , Rela , Stat3 , Vegfa
Chemotherapy-Induced Febrile NeutropeniaTp53
ChloracneCdk6 , Egfr
CholangiocarcinomaArid1a , Egfr , Erbb2 , Kras , Met , Pbrm1 , Pten , Smad4 , Tgfb1 , Tgfbr2 , Tp53
CholangitisTgfb2
CholestasisRela
CholesteatomaVegfa
Cholesteatoma, Middle EarRela , Tp53 , Vegfa
ChorioamnionitisTgfb1
Choroid Plexus CarcinomaTp53
Choroidal NeovascularizationIkbkb , Stat3 , Vegfa , Vegfb
Chromosome 17 DeletionTp53
Chromosome AberrationsCdk6
Chromosome DeletionCdkn2a
CHROMOSOME Xq26.3 DUPLICATION SYNDROMEArhgef6
Chronic Lymphoid LeukemiaBraf , Kras , Tp53
Chronic PeriodontitisRac2
Churg-Strauss SyndromeStat3
CicatrixSmad4
Clear-Cell Metastatic Renal Cell CarcinomaVegfa
Cleft PalateChuk , Egf , Gli3 , Shh , Tgfb1 , Tgfb2 , Tgfb3
ClubfootGli3
Cocaine-Related DisordersIlk , Mapk1 , Mapk3
Cocoon SyndromeChuk
Coffin-Siris SyndromeArid1a , Arid1b , Smarca4
Cognition DisordersMet , Smad4
ColitisChuk , Ikbkb , Pgf , Rela , Vegfa
Colitis, ExperimentalItga4 , Smad4
Colitis, IschemicVegfa
Colitis, UlcerativeTp53
Colonic NeoplasmsAkt1 , Akt2 , Bad , Braf , Brca2 , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Ikbkb , Kras , Nfkb1 , Pik3ca , Pik3r1 , Pten , Rela , Stat3 , Tcf7l2 , Tgfbr2 , Tp53 , Vegfa , Vegfc
Colonic PolypsIlk
Colorectal Cancer, Hereditary Nonpolyposis, Type 6Tgfbr2
Colorectal NeoplasmsAkt1 , Akt2 , Arid1a , Braf , Brca2 , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Met , Pik3ca , Pik3r1 , Pten , Raf1 , Smad4 , Tcf7l2 , Tgfb1 , Tgfbr1 , Tp53
Colorectal Neoplasms, Hereditary NonpolyposisSmad2 , Smad3 , Smad4 , Tgfbr1 , Tgfbr2
Congenital AbnormalitiesRac2
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Conjunctivitis, AllergicTgfb1
ConstipationArid1b
Copper-Overload CirrhosisMet , Smad2 , Stat3 , Tgfb1
Corneal NeovascularizationVegfa
Coronary Artery DiseaseAkt1 , Tgfb1 , Vegfa
Coronary DiseaseVegfa
Coronary RestenosisMapk1 , Tp53
Costello SyndromeBraf , Kras , Map2k1
COWDEN SYNDROME 5Pik3ca
Cranioectodermal DysplasiaTgfb3
Craniofacial AbnormalitiesEgfr , Lrp2 , Pten , Smad2 , Smad3 , Smad4 , Tgfb2 , Tgfbr2 , Tp53
CraniopharyngiomaBraf
Crohn DiseasePgf , Smad3 , Stat3 , Vegfa
Crossed Polydactyly, Type IGli3
CryptorchidismArid1b , Bcl2l1 , Rela
Currarino TriadActl6a , Pik3ca
CyanosisTgfb2
Cystadenocarcinoma, SerousTp53
Cystic FibrosisTgfb1
CystitisRela
Cytomegalovirus InfectionsStat1
DeafnessSmad4
Deafness, Autosomal Recessive 97Met
DementiaE2f1 , Egfr
Dementia, VascularTp53
Demyelinating DiseasesShh , Tp53
Depressive DisorderBcl2l1
DermatitisIkbkb
Dermatitis HerpetiformisVegfa
Dermatitis, Allergic ContactVegfa
Dermatitis, AtopicMapk8 , Tgfb1
Dermatitis, ContactVegfa
Dermatitis, IrritantStat3
Developmental DisabilitiesAkt3 , Lrp2 , Pten
Diabetes ComplicationsVegfa
Diabetes MellitusPten , Rac1 , Tcf7l2
Diabetes Mellitus, ExperimentalAkt1 , Bad , Bcl2l1 , Casp9 , Egfr , Ikbkb , Lrp2 , Mapk1 , Mapk3 , Met , Pgf , Pik3r1 , Rela , Smarca4 , Stat1 , Stat3 , Tgfb1 , Tgfb2 , Tp53 , Vegfa , Vegfb
Diabetes Mellitus, Type 1Casp9 , Cdk4 , E2f1 , Egfr , Stat3 , Tgfb1
Diabetes Mellitus, Type 2Akt1 , Akt2 , Bad , Bcl2l1 , Casp9 , Cdk4 , Egfr , Ikbkb , Nfkb1 , Pik3r1 , Rela , Smad4 , Stat3 , Tcf7l2 , Tgfb1 , Tgfbr2 , Vegfa
Diabetes, GestationalTcf7l2
Diabetic AngiopathiesRela , Vegfa
Diabetic CardiomyopathiesBad , Erbb2
Diabetic CystopathyBad
Diabetic NephropathiesEgf , Mapk1 , Pgf , Pten , Rela , Stat3 , Tcf7l2 , Tgfb1 , Tgfbr2 , Tp53 , Vegfa
Diabetic NeuropathiesBad , Pgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa
Diabetic RetinopathyCasp9 , Egfr , Itga4 , Pgf , Vegfa
Diaphyseal Dysplasia 1, ProgressiveTgfb1
Dilatation, PathologicTgfb1
Disease Models, AnimalAkt1 , Erbb2 , Kras , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Stat3 , Tp53
Disease ProgressionEgf , Egfr , Erbb2 , Pten , Stat1 , Vegfb
Donnai-Barrow SyndromeLrp2
Drug-Induced Liver InjuryBad
Drug-induced NeutropeniaTp53
Drug-Related Side Effects and Adverse ReactionsTp53
Dry Eye SyndromesTgfb1
Duodenal UlcerStat3 , Tgfb1 , Vegfa
Dysembryoplastic Neuroepithelial TumorBraf
Dyskeratosis Congenita, Autosomal RecessiveTp53
Dyskinesia, Drug-InducedRela
Dysplastic Nevus SyndromeCdkn2a
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Ectodermal Dysplasia, Hypohidrotic, with Immune DeficiencyIkbkg
EdemaCasp9
Ehlers-Danlos SyndromeTgfb1
EmphysemaTp53
EncephalitisRela
Encephalitis, ViralE2f1
Encephalomyelitis, Autoimmune, ExperimentalCasp9 , Gli1 , Itga4 , Shh , Stat1 , Stat3 , Tgfb1 , Tgfb2 , Vegfa
Endometrial HyperplasiaKras , Pten
Endometrial NeoplasmsArid1a , Bcl2l1 , Brca2 , Ccnd1 , Cdk4 , Cdkn2a , Erbb2 , Kras , Met , Pik3ca , Pten , Rb1 , Smad2 , Smad3 , Smad4 , Stat3 , Tp53 , Vegfa
EndometriosisBcl2l1 , Egfr , Kras , Tgfb2 , Vegfa
Endomyocardial FibrosisTgfb1
EndotoxemiaPgf
Enterocolitis, NecrotizingEgf , Ikbkg
Eosinophilic EsophagitisTgfb1
Epidermal HyperplasiaStat3
Epidermal NevusKras , Pik3ca
EpilepsyAkt1 , Arid1b , Ilk , Pgf
Epilepsy, GeneralizedMapk10
Epilepsy, Temporal LobeCdc42 , Pgf , Shh , Vegfa
Epileptic Encephalopathy, Lennox-Gastaut TypeMapk10
Erectile DysfunctionAkt1 , Bad , Bcl2l1 , Ccnd1 , Tgfb1 , Vegfa
Erythema MultiformeVegfa
Esophageal Atresia with or without Tracheoesophageal FistulaBrca2 , Gli3 , Shh
Esophageal NeoplasmsBrca2 , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Kras , Met , Pik3ca , Smad4 , Tgfbr2 , Tp53
Esophageal Squamous Cell CarcinomaBrca2 , Ccnd1 , Cdkn2a , Egfr , Rb1 , Tp53
Esophagitis, PepticEgfr
Eye AbnormalitiesShh , Tgfb2 , Tgfbr2
Eye Diseases, HereditaryLrp2
Facial AsymmetryPik3ca
Failure to ThriveArid1b
Familial Primary Pulmonary HypertensionSmad4
Familial SchizencephalyShh
Fanconi AnemiaBrca2
Fanconi Anemia, Complementation Group D1Brca2
FANCONI ANEMIA, COMPLEMENTATION GROUP RRad51
FatigueTgfbr2
Fatty LiverMapk8 , Nfkb1 , Pten , Rela
Fetal Alcohol Spectrum DisordersPten
Fetal DiseasesChuk
FeverStat3
FibrosarcomaCdc42
FibrosisAkt1 , Stat3 , Tgfb1
Fluoride PoisoningGli1 , Shh
Fractures, BoneTgfbr2
Gallbladder NeoplasmsEgf , Egfr , Erbb2 , Kras , Met , Tgfa , Tgfb1 , Tp53
Gangliosidosis, GM1Brca2
GastrinomaMet
GastroenteritisTgfa
Gastrointestinal NeoplasmsErbb2 , Pik3ca , Pten , Smad4
Gastrointestinal Stromal TumorsBraf , Kras
Genetic Diseases, InbornArid1a , Arid1b , Brca2 , Cdc42 , Itga11 , Jak1 , Mapk1 , Pik3r2 , Pld1 , Pten , Smad2 , Smarca4
Genetic Predisposition to DiseaseEgf , Rad51 , Tgfa
Genital Diseases, FemaleSmad2
Genomic InstabilityCcnd1
GerminomaBraf , Cdkn2a
GingivitisVegfa
GlaucomaBad , Cdkn2a , Tgfb2 , Vegfa
Glaucoma, NeovascularVegfa
Glaucoma, Primary Open AngleTp53
GlioblastomaAkt1 , Braf , Cdk6 , Cdkn2a , Egf , Egfr , Erbb2 , Met , Pgf , Pik3ca , Pik3r1 , Pten , Tp53 , Vegfa
GliomaAkt2 , Bad , Braf , Brca2 , Cdkn2a , Egfr , Erbb2 , Met , Pik3ca , Pten , Raf1 , Tp53
GliosarcomaVegfa
GliosisItga4 , Mapk1 , Mapk3
GlomerulonephritisMapk1 , Vegfa
Glomerulonephritis, IGAShh , Tgfb1
Glomerulonephritis, MembranoproliferativeTgfbr2
Glomerulonephritis, MembranousLrp2 , Shh
Glomerulosclerosis, Focal SegmentalShh , Tgfb1
Glomus Tympanicum TumorVegfa
Glucosephosphate Dehydrogenase DeficiencyIkbkg
Graft vs Host DiseaseTp53 , Vegfa
Granuloma, PyogenicStat3
Granulosa Cell TumorCdkn2a , Vegfa
Graves DiseaseTp53 , Vegfa
Greig cephalopolysyndactyly syndromeGli3
Growth DisordersPik3ca
Growth Mental Deficiency Syndrome of MyhreSmad4
Hamartoma Syndrome, MultipleAkt1 , Egfr , Pik3ca , Pten
Head and Neck NeoplasmsBcl2l1 , Egfr , Mapk1 , Mapk3 , Pik3ca , Rad51 , Tgfa , Tp53 , Vegfa
Hearing LossBcl2l1 , Stat1
Hearing Loss, SensorineuralLrp2
Heart ArrestAkt1
Heart Defects, CongenitalTgfb2 , Vegfa
Heart DiseasesCasp9 , Rac2 , Stat3 , Tgfb1 , Vegfa
Heart FailureErbb2 , Pgf , Rac1 , Tp53 , Vegfa
Heart Septal Defects, VentricularBraf , Pgf , Smarca4 , Tgfb3
Heat StrokeNfkb1 , Rela
HELLP SyndromeErbb2
HemangiomaPten
Hemangioma, CapillaryAkt3
Hemangioma, Cavernous, Central Nervous SystemPten
HemangiosarcomaCcnd1 , Kras , Stat3 , Tp53 , Vegfa , Vegfc
Hematologic DiseasesBcl2l1 , Brca2
HemimegalencephalyPik3ca
Hemophilia ATgfb1
Hepatitis C, ChronicStat3
Hepatitis, AnimalMet
Hepatitis, AutoimmuneTgfb1
Hepatitis, ChronicMet , Smad2 , Stat3 , Tgfb1
HepatoblastomaTgfa , Tp53
HepatomegalyPten
Hereditary Breast and Ovarian Cancer SyndromeBrca2
Hernia, DiaphragmaticLrp2 , Tgfb1
Hernia, InguinalTgfbr2
Hernias, Diaphragmatic, CongenitalMet , Stat3 , Vegfa
High MyopiaLrp2
Hirschsprung DiseaseErbb2 , Shh
HIV InfectionsCdc42
HoloprosencephalyShh
Holoprosencephaly 3Shh
Holt-Oram SyndromeTgfb2
Huntington DiseaseE2f1 , Egfr , Nfkb1
Hyper-Ige Recurrent Infection Syndrome, Autosomal DominantStat3
Hyper-IgM Immunodeficiency, X-Linked, with Ectodermal Dysplasia, HypohidroticIkbkg
HyperalgesiaMapk1 , Mapk3 , Mapk8 , Mapk9 , Raf1 , Stat3
HypercholesterolemiaVegfa
HyperinsulinismPten
HyperlipidemiasTgfb1
HyperoxaluriaNfkb1
HyperoxiaCdk4 , Tgfb1
Hyperoxic Lung InjuryShh
HyperparathyroidismCcnd1
HyperplasiaAkt1 , Ccnd1 , Cdkn2a , Egfr , Ikbkb , Pik3ca , Tcf7l2 , Tgfb1 , Tgfbr2 , Vegfa
HypersensitivityTgfb1
Hypersensitivity, ImmediateEgfr
HypertensionAkt1 , Akt2 , Arid1b , Bad , Cdkn2a , Egfr , Ikbkb , Kras , Lrp2 , Mapk8 , Pgf , Pik3r1 , Pten , Rad51 , Ralbp1 , Rela , Tgfb1 , Tgfb3 , Tp53 , Vegfa
Hypertension, PortalPik3r1 , Pten , Vegfa
Hypertension, PulmonaryBcl2l1 , Egfr , Pgf , Rela , Smad4 , Tgfa , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfb
Hypertension, RenovascularRela
HypertrichosisArid1b
HypertrophyMapk1 , Mapk3 , Pten
Hypertrophy, Left VentricularEgfr , Pbrm1 , Pten , Rac1 , Rela , Smarca4
Hypertrophy, Right VentricularAkt1 , Tgfa , Tgfb1
HyperuricemiaStat3
Hypoglossal Nerve InjuriesSmad2 , Smad3 , Smad4
HypoglycemiaAkt2 , Pik3r1
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
Hypomagnesemia 4, RenalEgf
Hypomagnesemia PrimaryEgf
HypopigmentationGli3
HypospadiasGli3
Hypothalamic HamartomasGli3
HypothyroidismBad , Shh
HypotrichosisRb1
Hypotrichosis, Localized, Autosomal Recessive, 3Rb1
Hypoxia-Ischemia, BrainBcl2l1 , Vegfa
Idiopathic Pulmonary FibrosisStat3
Immunodeficiency 14Pik3cd
Immunodeficiency 15Ikbkb
IMMUNODEFICIENCY 31AStat1
Immunodeficiency 36Pik3r1
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
IMMUNODEFICIENCY, COMMON VARIABLE, 12Nfkb1
Impotence, VasculogenicTgfbr2
Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal DementiaEgf
Incontinentia PigmentiIkbkg
Infarction, Middle Cerebral ArteryBad , Ikbkb , Pld1 , Shh , Stat3
Infertility, FemaleMapk1 , Mapk3 , Tp53
Infertility, MaleTp53
InflammationAkt1 , Chuk , Egfr , Pgf , Stat3 , Tgfa , Tgfb1 , Vegfa
Inflammatory Bowel Disease 11Rela , Stat3 , Vegfa
Inflammatory Bowel DiseasesIkbkb , Itga4 , Vegfa
INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 2Egfr
Influenza, HumanStat1
Insulin ResistanceAkt2 , Bad , Egfr , Ikbkb , Pik3r1 , Pten , Rb1 , Rela , Tcf7l2
InsulinomaTgfa , Tgfb1
Intellectual DisabilityArhgef6 , Arid1b , Kras , Pten , Ralgds
Intermittent ClaudicationBad
Intervertebral Disc DegenerationTgfb1
Intervertebral Disc DisplacementAkt1
Intestinal PolyposisGli3 , Smad4
Intestinal PolypsCcnd1
Intestinal Pseudo-ObstructionRb1
Intracranial Arteriovenous MalformationsVegfa
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
Invasive Pulmonary AspergillosisVegfa
Irritable Bowel SyndromeIkbkg
IschemiaAkt2 , Arid1b , Mapk9 , Raf1 , Tp53
Ischemic Attack, TransientBad , Casp9 , Cdkn2a , Ikbkb , Ilk , Nfkb1 , Pten , Stat3
Job SyndromeStat3
Juvenile Polyposis SyndromeSmad4
Juvenile Polyposis with Hereditary Hemorrhagic TelangiectasiaSmad4
Keratoacanthoma FamilialTgfbr1
KeratosisTp53
Keratosis, ActinicTgfb1
Keratosis, SeborrheicPik3ca
Kidney DiseasesEgf , Lrp2 , Mapk1 , Tgfb1 , Tgfbr1 , Tgfbr2
Kidney Failure, ChronicLrp2 , Nfkb1 , Pgf , Rela , Tgfb1
Kidney NeoplasmsAkt1 , Braf , Ccnd1 , Cdkn2a , Erbb2 , Kras , Mapk1 , Mapk3 , Met , Raf1
Kidney Reperfusion InjuryIkbkb , Shh
Language Development DisordersPten
Laryngeal NeoplasmsEgfr
Laryngotracheal Stenosis, Progressive, with Short Stature and ArthropathySmad4
Learning DisordersIkbkg , Vegfa
LeiomyomaBcl2l1 , Pten , Smad3 , Tgfbr1
LeiomyosarcomaCdkn2a
LEOPARD SyndromeBraf , Pten , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD syndrome, 2Raf1
LeukemiaBad , Ccnd1 , Cdkn2a , Pten , Tp53
Leukemia, ExperimentalCdkn2a
Leukemia, Hairy CellMap2k1
Leukemia, Large Granular LymphocyticStat3
Leukemia, Lymphocytic, Chronic, B-CellBraf , Itga4 , Kras , Tp53
Leukemia, LymphoidBcl2l1
Leukemia, Megakaryoblastic, AcutePten , Tp53
Leukemia, Megakaryoblastic, of Down SyndromeTp53
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveBcl2l1 , Braf , Cdkn2a , Vegfa
Leukemia, MyeloidVegfa
Leukemia, Myeloid, AcuteBcl2l1 , Ccnd1 , Cdk6 , Cdkn2a , Jak1 , Kras , Met , Stat3 , Tp53
Leukemia, Myelomonocytic, JuvenileKras , Rac2
Leukemia, Promyelocytic, AcuteAkt1 , Gli1
Leukemia, T-CellCdkn2a , Stat3
Leukemia-Lymphoma, Adult T-CellStat3 , Tp53
LeukocytosisItga4 , Kras
Leukodystrophy, Hypomyelinating, with Hypodontia and Hypogonadotropic HypogonadismTp53
Leukoplakia, OralTp53
Leydig Cell TumorCdk4
Li-Fraumeni SyndromeTp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni-Like SyndromeTp53
Lichen Planus, OralTp53
Limb Deformities, CongenitalChuk , Shh , Tgfb2
Limb IschemiaVegfa
Lip NeoplasmsTp53
Lipodystrophy, Familial PartialAkt2
LipomaPten
LipomatosisPten
LiposarcomaCdk4
Lipoyltransferase 1 DeficiencyTp53
Liver CirrhosisPgf , Smad3 , Stat1 , Stat3 , Tgfb1 , Vegfa
Liver Cirrhosis, AlcoholicRela , Smad3 , Tgfb1
Liver Cirrhosis, BiliaryNfkb1
Liver Cirrhosis, ExperimentalCdk4 , Egf , Ilk , Met , Pgf , Rac2 , Rela , Smad2 , Smad4 , Tgfb1 , Tgfb3 , Tgfbr1 , Tgfbr2 , Vegfa
Liver DiseasesBcl2l1 , Nfkb1 , Rac1
Liver Diseases, ParasiticKras , Smad4 , Tp53
Liver FailureVegfa
Liver Failure, AcuteMapk8 , Met
Liver InjuryStat3
Liver NeoplasmsAkt1 , Braf , Ccnd1 , Cdkn2a , Kras , Met , Pik3ca , Raf1 , Stat3 , Tgfa , Tp53
Liver Neoplasms, ExperimentalBcl2l1 , Ccnd1 , Kras , Map2k1 , Met , Rad51 , Rb1 , Stat3 , Tgfa , Tp53
Liver Reperfusion InjuryBad , Bcl2l1 , Ikbkg , Mapk8
Loeys-Dietz SyndromeSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
LOEYS-DIETZ SYNDROME 2Tgfbr2
Loeys-Dietz Syndrome 3Smad3
Loeys-Dietz Syndrome 4Tgfb2 , Tgfb3
Loeys-Dietz Syndrome 5Tgfb3
Loeys-Dietz Syndrome, Type 1bTgfbr2
Long QT SyndromeIlk , Pten
Low Tension GlaucomaTp53
Lung DiseasesEgfr , Tgfb1 , Vegfa
Lung Diseases, InterstitialTgfb1
Lung InjuryTgfa
Lung NeoplasmsAkt1 , Bcl2l1 , Braf , Brca2 , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Ikbkg , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Pten , Raf1 , Smarca4 , Tgfb1 , Tgfbr2 , Tp53
Lupus Erythematosus, SystemicPgf
Lupus NephritisEgf
LymphangiectasisRaf1
LymphangioleiomyomatosisStat1 , Stat3 , Vegfd
Lymphatic MetastasisEgfr , Erbb2 , Pten , Rela , Smad4 , Stat3 , Tp53 , Vegfa , Vegfc , Vegfd
LymphedemaPgf
LYMPHEDEMA, HEREDITARY, IDVegfc
Lymphoblastic Leukemia, Acute, with Lymphomatous FeaturesJak1
LymphomaCdkn2a , Kras , Pten , Rac2 , Rela , Tp53
Lymphoma, B-Cell, Marginal ZoneTp53
Lymphoma, Large B-Cell, DiffuseCdkn2a , Gli1 , Pik3ca , Pik3cb , Pik3cd
Lymphoma, Large-Cell, AnaplasticStat3
Lymphoma, Mantle-CellCcnd1 , Pik3cd
Lymphoma, Non-HodgkinBraf , Ccnd1 , Map2k1 , Pik3ca , Tp53
Lymphoma, T-CellAkt1 , Arid1a , Stat3 , Tp53
Lymphoma, T-Cell, CutaneousArid1a , Braf , Cdkn2a , Tp53
Lymphoproliferative DisordersStat3
Macrocephaly Autism SyndromePten
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
Macular DegenerationBad , Vegfa
Macular EdemaVegfa
Malformations of Cortical DevelopmentAkt3 , Pik3ca
Malformations of Cortical Development, Group IIPten
Mammary Neoplasms, AnimalCcnd1 , Cdc42 , Cdk4 , Egfr , Erbb2 , Pik3r1 , Rb1 , Stat3
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Bcl2l1 , Casp9 , Ccnd1 , Cdc42 , Cdk4 , Cdk6 , Cdkn2a , Egfr , Erbb2 , Ilk , Pik3r1 , Pten , Rb1 , Rela , Stat1 , Stat3 , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa
Mandibular NeoplasmsBraf
Marfan SyndromeTgfbr2
Marijuana AbuseAkt1
MastoiditisRela
Median NeuropathyErbb2
MedulloblastomaBrca2 , Cdk6 , Erbb2 , Pik3ca , Rb1 , Stat3 , Tp53
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3 , Gli3 , Pten
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
MelanomaAkt1 , Bcl2l1 , Braf , Brca2 , Cdk4 , Cdkn2a , E2f1 , Erbb2 , Kras , Map2k1 , Nfkb1 , Pik3ca , Pik3r1 , Pten , Rac1 , Rac2 , Raf1 , Tp53 , Vegfa , Vegfc
Melanoma Astrocytoma SyndromeCdkn2a
Melanoma, Cutaneous MalignantBrca2 , Cdk4 , Cdkn2a , Stat3
Melanoma, Cutaneous Malignant, Susceptibility To, 1Cdkn2a , Pten
Melanoma, Cutaneous Malignant, Susceptibility To, 2Cdkn2a
Melanoma, Cutaneous Malignant, Susceptibility To, 3Cdk4
Melanoma, ExperimentalIkbkb
Melanoma-Pancreatic Cancer SyndromeCdkn2a
Memory DisordersStat3 , Vegfa
Meningeal NeoplasmsAkt1
MeningiomaAkt1 , Pten
Meningioma, FamilialPten
Meningitis, PneumococcalRela
Mental Retardation, Autosomal Dominant 12Arid1b
Mental Retardation, Autosomal Dominant 14Arid1a
Mental Retardation, Autosomal Dominant 16Smarca4
Mental Retardation, X-LinkedArhgef6
Mental Retardation, X-Linked 46Arhgef6
Mental Retardation, X-Linked NonsyndromicArhgef6
MesotheliomaCdkn2a , Egfr , Tp53
Mesothelioma, MalignantCdk6 , Cdkn2a , Egfr , Ilk , Met , Raf1 , Tgfb2 , Tp53
Metabolic Syndrome XTgfb1 , Vegfa
MetaplasiaEgf
MicrocephalyArid1b
MICROCEPHALY AND CHORIORETINOPATHY, AUTOSOMAL RECESSIVE, 2Cdk6
Microcephaly, Primary Autosomal Recessive, 5Brca2
Micronuclei, Chromosome-DefectiveCdkn2a , Rad51
Microphthalmia, Cataracts, and Iris AbnormalitiesSmad4
Microphthalmia, Isolated, with Coloboma 5Shh
Microsatellite InstabilityArid1a , Braf , Tgfbr2
Microvascular Complications of Diabetes, Susceptibility To, 1Vegfa
Microvascular Complications of Diabetes, Susceptibility To, 2Vegfa
Microvascular Complications of Diabetes, Susceptibility To, 7Vegfa
Migraine DisordersTgfbr2
Mirror Movements 2Rad51
Mixed Tumor, MullerianCdkn2a , Erbb2 , Pik3ca , Pik3r1 , Pten , Tp53
Miyoshi Muscular Dystrophy 3Brca2
Mood DisordersAkt1
Motor Skills DisordersPten
Mouth NeoplasmsCdkn2a , Erbb2 , Kras , Pik3ca , Pten , Tp53
Mucocutaneous Lymph Node SyndromeVegfa
MucositisTgfa
Multiple MyelomaBcl2l1 , Braf , Ccnd1 , Cdk4 , Cdkn2a , Kras , Met , Pik3ca , Tgfb1 , Tp53 , Vegfa
Multiple Organ FailureMapk1
Multiple SclerosisGli1 , Shh , Vegfa
Multiple Sclerosis, Chronic ProgressiveShh
Muscular AtrophyAkt1 , Chuk , Ikbkb
Muscular DiseasesSmad4 , Tgfb1
Muscular DystrophiesPten
Muscular Dystrophy, DuchenneTgfb1
Muscular Dystrophy, Limb-Girdle, Type 2BBrca2
Muscular Dystrophy, Limb-Girdle, Type 2LBrca2
Musculoskeletal AbnormalitiesTgfb2
Mycobacterial and Viral Infections, Susceptibility To, Autosomal RecessiveStat1
Mycobacterium InfectionsStat1
Mycobacterium Infections, NontuberculousStat1
Myelodysplastic SyndromesCdkn2a , Kras , Tp53
Myeloproliferative DisordersKras
Myocardial InfarctionAkt1 , Bcl2l1 , Mapk1 , Pgf , Shh , Smad2 , Smad4 , Tgfb1 , Tgfb2 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa , Vegfb
Myocardial IschemiaCcnd1 , Erbb2 , Pgf , Ralbp1 , Vegfa
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Bcl2l1 , Casp9 , Mapk1 , Mapk8 , Mapk9 , Pten , Rela , Shh , Smad3 , Smad4 , Stat1 , Stat3 , Tgfb1 , Tp53 , Vegfa
Nasal PolypsMet , Stat3 , Tgfb1 , Vegfa
Nasopharyngeal CarcinomaAkt2 , Arid1a , Ccnd1 , Cdkn2a , Erbb2 , Kras , Pik3ca , Pten , Tp53
Nasopharyngeal NeoplasmsCcnd1 , Egfr , Pik3ca , Tp53
NecrosisCdc42
Nematode InfectionsPik3r1
Neoplasm InvasivenessCdkn2a , Egf , Egfr , Mapk1 , Mapk3 , Met , Pten , Rela , Tgfb1
Neoplasm MetastasisAkt2 , Braf , Cdkn2a , Egf , Egfr , Erbb2 , Kras , Mapk1 , Mapk3 , Mapk9 , Met , Pten , Rac1 , Rb1 , Stat3 , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa
Neoplasm Recurrence, LocalEgfr , Erbb2 , Vegfa
NeoplasmsBraf , Cdkn2a , Erbb2 , Kras , Map2k1 , Met , Pik3ca , Pik3r1 , Pten , Rb1 , Tp53 , Vegfa
Neoplasms, Cystic, Mucinous, and SerousMet
Neoplasms, ExperimentalCcnd1 , Cdk4 , Erbb2 , Kras , Rb1 , Rela , Tp53 , Vegfa
Neoplasms, Germ Cell and EmbryonalCdk4 , Cdkn2a , Erbb2
Neoplasms, Plasma CellBcl2l1
Neoplasms, Squamous CellBrca2
Neoplastic Syndromes, HereditaryBrca2 , Cdk4 , Cdkn2a , Met , Pik3ca , Pten , Rb1 , Smad4 , Tp53
Neovascularization, PathologicVegfa
NephritisItga4
Nephrolithiasis, Calcium OxalateTgfb1
NephrosisLrp2
Nephrotic SyndromeTgfb1
Nerve DegenerationMapk1 , Mapk3 , Tgfa , Vegfa
Nerve Sheath NeoplasmsCdkn2a , Met , Pten , Tp53
Nervous System DiseasesCasp9 , Tp53
Neural Tube DefectsGli3
NeuralgiaTgfb1
NeurilemmomaCdkn2a
NeuroblastomaArid1a , Arid1b , Cdkn2a , Kras , Met , Pik3ca , Tp53
Neurodevelopmental DisordersArid1b , Pten , Tcf7l2
Neuroendocrine TumorsBraf
Neurofibromatosis 1Vegfa
Neurofibromatosis 2Vegfa
NeurofibrosarcomaVegfa
Neuroma, AcousticVegfa
Neurotoxicity SyndromesBcl2l1
Neutrophil Immunodeficiency SyndromeRac2
NevusBraf
Nevus, Sebaceous of JadassohnKras
Nicolaides Baraitser SyndromeArid1b
Niemann-Pick Disease, Type CStat3
Non-alcoholic Fatty Liver DiseaseIkbkg , Stat3 , Tgfb1
Nonseminomatous Germ Cell TumorBraf
Nonsyndromic DeafnessMet
Noonan SyndromeBraf , Kras , Map2k1 , Raf1
Noonan syndrome 3Kras
Noonan Syndrome 5Raf1
Noonan Syndrome 7Braf
Nose NeoplasmsTp53
ObesityAkt1 , Akt2 , Bad , Cdk4 , Cdkn2a , Egfr , Ikbkb , Pgf , Pik3r1 , Rb1 , Rela , Smarca4 , Stat3 , Tgfb1
Occupational DiseasesTgfb1
Ocular HypertensionBcl2l1 , Gli1 , Shh
Oculocutaneous Albinism, Type IVBrca2
Odontogenic CystsSmad4
Odontogenic MyxomaTp53
Optic Atrophy, Hereditary, LeberTp53
Oral Squamous Cell CarcinomaMet
Oral Submucous FibrosisTgfb1 , Tp53
Oropharyngeal NeoplasmsTp53
Ossification, HeterotopicSmad4
OsteoarthritisBad , Cdkn2a , Smad3
Osteoarthritis, KneeTgfa
OsteochondrodysplasiasPten , Tgfb1 , Tgfb2 , Tgfbr1 , Vegfa
Osteofibrous DysplasiaMet
OsteoporosisTgfb1
Osteoporosis, PostmenopausalTgfb1
OsteosarcomaAkt1 , Brca2 , Egfr , Met , Rb1 , Tp53 , Vegfa
Otitis MediaRela , Vegfa
Otitis Media with EffusionVegfa
Ovarian CystsNfkb1
Ovarian Epithelial CancerPik3ca , Tp53
Ovarian NeoplasmsAkt1 , Akt2 , Bcl2l1 , Braf , Brca2 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3r1 , Pten , Rad51 , Rb1 , Rela , Smad2 , Smad4 , Smarca4 , Stat3 , Tp53 , Vegfa , Vegfc , Vegfd
Oxygen-Induced RetinopathyMapk8 , Stat3 , Vegfa
Paget's Disease, MammaryErbb2
PainAkt1
Pallister-Hall SyndromeGli3
Pancreatic AdenocarcinomaCdkn2a , Erbb2 , Kras , Pik3ca , Smad4 , Tp53
Pancreatic CarcinomaCdkn2a , Kras , Smad4 , Tp53
Pancreatic NeoplasmsAkt2 , Arid1a , Arid1b , Bcl2l1 , Boc , Brca2 , Cdkn2a , Egf , Egfr , Gli1 , Gli3 , Ilk , Itga11 , Itga4 , Itga9 , Kras , Lrp2 , Met , Pbrm1 , Pten , Rad51 , Rb1 , Rela , Shh , Smad3 , Smad4 , Smarca4 , Stat3 , Tcf7l2 , Tgfa , Tgfb1 , Tgfbr2 , Tp53 , Vegfb , Wnt9a
PancreatitisEgf , Ikbkb , Met
Pancreatitis, Acute NecrotizingRela
Pancreatitis, ChronicBad
Pancreatitis, ExperimentalIkbkg
Pancreatitis, Experimental, Acute Bcl2l1 , Kras
Pancreatitis, Experimental, Chronic Gli1
Papillary Renal Cell Carcinoma, SporadicBraf , Cdkn2a , Erbb2 , Pik3ca , Tp53
PapillomaCcnd1 , Egfr , Erbb2 , Tgfb1
Papilloma, Choroid PlexusTp53
Papilloma, InvertedVegfa
Papillomavirus InfectionsCdkn2a
Paranasal Sinus NeoplasmsTp53
ParaplegiaAkt1
Paraquat LungTgfb1
Parkinson DiseaseAkt1 , Egf , Egfr , Erbb2
Parkinson Disease, SecondaryShh
Parkinsonian DisordersBad , Egfr , Rela , Shh
Patterson Stevenson SyndromeShh
Pemphigoid, BullousVegfa
Penile IndurationTgfb1
Penile NeoplasmsCcnd1 , Kras , Pik3ca , Tp53
Periodontal AtrophyVegfa
PeriodontitisMet
Peripheral Nerve InjuriesShh
Peripheral Nervous System DiseasesCasp9 , Cdkn2a , Gli1
Peripheral Nervous System NeoplasmsPten
Peritoneal FibrosisTgfb1
Persistent CloacaShh
Persistent Hyperplastic Primary VitreousCdkn2a
Phyllodes TumorEgfr , Rb1 , Tp53
PiebaldismGli3
Pituitary Dwarfism 1Brca2
Pituitary NeoplasmsRb1
PlasmacytomaCdkn2a
Pleomorphic Xanthoastrocytoma Braf , Cdk6 , Egfr , Gli3 , Met , Rala
Pleural DiseasesTgfb1
PneumoniaEgf , Ikbkb , Itga4 , Tgfb1
Pneumonia, BacterialChuk , Pgf , Stat3
Pneumonia, PneumococcalMapk1 , Mapk3
PoisoningCdkn2a
Polyarteritis NodosaVegfa
Polycystic Kidney, Autosomal DominantLrp2
Polycystic Kidney, Autosomal RecessiveAkt1 , Egfr , Pik3ca
Polycystic Ovary SyndromeVegfa
Polycythemia VeraBcl2l1 , Jak1
PolydactylyGli3 , Pten , Shh
Polydactyly, PostaxialGli3
Polydactyly, Preaxial 4Gli3
Polydactyly, Preaxial IIShh
PolymicrogyriaAkt3
PolyploidyTp53
Polypoidal Choroidal VasculopathyVegfa
Pre-EclampsiaErbb2 , Itga4 , Pgf , Vegfa
Precancerous ConditionsAkt1 , Ccnd1 , Cdkn2a , Egf , Mapk8 , Mapk9 , Smad3 , Smad4 , Stat3 , Tp53 , Vegfa
Precursor B-Cell Lymphoblastic Leukemia-LymphomaBcl2l1 , Ccnd1 , Cdkn2a , Stat3 , Tp53
Precursor Cell Lymphoblastic Leukemia-LymphomaBcl2l1 , Ccnd1 , Cdk6 , Cdkn2a , Kras , Rb1 , Tp53
Precursor T-Cell Lymphoblastic Leukemia-LymphomaCdkn2a , Kras , Stat1
Pregnancy in DiabeticsVegfa
Premature BirthPgf
Pressure UlcerVegfa
PRIMARY AUTOSOMAL RECESSIVE MICROCEPHALY 12Cdk6
Primary MyelofibrosisTgfb1 , Tp53
ProlactinomaLrp2
Prostate Cancer, SomaticPten
Prostatic HyperplasiaBad , Cdk4 , Pten , Rela
Prostatic Intraepithelial NeoplasiaCcnd1 , Kras , Pten , Rela , Smad4
Prostatic NeoplasmsAkt1 , Bad , Bcl2l1 , Braf , Brca2 , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , Chuk , E2f1 , Egf , Egfr , Erbb2 , Gli1 , Ilk , Kras , Lrp2 , Map2k1 , Mapk10 , Mapk3 , Met , Pik3ca , Pik3cd , Pik3r1 , Pten , Rac2 , Ralbp1 , Rb1 , Rela , Smad3 , Smad4 , Smarca4 , Stat1 , Stat3 , Tgfa , Tgfb1 , Tgfbr2 , Tp53 , Vegfa
ProstatitisSmad4
ProteinuriaTgfb1 , Vegfa
Proteus SyndromeAkt1 , Pten
Pseudoxanthoma ElasticumVegfa
PsoriasisIkbkb , Stat3 , Tgfa , Tgfb1 , Tp53 , Vegfa
Psychoses, Substance-InducedAkt1
Pten Hamartoma Tumor Syndrome with Granular Cell TumorPten
PterygiumTp53 , Vegfa , Vegfc
Pulmonary Disease, Chronic ObstructiveBcl2l1 , Egfr , Mapk8 , Smad4 , Tgfb1 , Tp53 , Vegfa
Pulmonary EdemaTgfa , Vegfa
Pulmonary EmphysemaPgf , Tgfb1
Pulmonary FibrosisBad , Egf , Egfr , Smad4 , Stat1 , Stat3 , Tgfa , Tgfb1 , Tgfbr2
Purpura, Thrombocytopenic, IdiopathicTgfb1
PyelonephritisPgf
Radiation InjuriesTgfbr2
Radiation Injuries, ExperimentalMapk1 , Mapk3
Radiation PneumonitisTgfb1
RASopathiesBraf , Kras , Map2k1 , Raf1
Rectal NeoplasmsEgfr , Pik3ca
RecurrenceErbb2 , Kras , Vegfc
Renal FibrosisKras , Mapk1
Renal Insufficiency, ChronicShh
Reoviridae InfectionsStat1
Reperfusion InjuryAkt1 , Bad , Casp9 , Ccnd1 , Cdc42 , Egf , Mapk8 , Mapk9 , Met , Pik3r1 , Pten , Rela , Stat1 , Stat3 , Tgfbr2 , Tp53 , Vegfc , Vegfd
Respiratory System AbnormalitiesTgfb2 , Tgfb3
Retina Reperfusion InjuryBad , Bcl2l1 , Stat3 , Vegfa
Retinal DetachmentCasp9
Retinal DiseasesVegfa
Retinal NeovascularizationVegfa , Vegfb
Retinal TelangiectasisVegfa
Retinal Vein OcclusionVegfa , Vegfb
Retinitis PigmentosaItga4 , Pten , Vegfa
RetinoblastomaRb1
Retinopathy of PrematurityVegfa
Rhabdoid Tumor Predisposition Syndrome 2Smarca4
RhabdomyosarcomaBrca2 , Cdkn2a , Tp53 , Vegfa
RhinitisCdc42 , Tgfb1 , Vegfa
Rhinitis, Allergic, SeasonalVegfa
Salivary Gland NeoplasmsCcnd1
SarcoidosisTgfb1
Sarcoidosis, PulmonaryTgfb1
SarcomaMet , Pik3ca , Smarca4 , Tp53
Sarcoma Family Syndrome of Li and FraumeniTp53
Sarcoma, ExperimentalKras
Sarcoma, KaposiTp53
Sarcoma, MyeloidKras
SchizencephalyShh
SchizophreniaAkt1 , Egf , Egfr , Mapk3 , Met , Pik3cb , Tp53
Schizophrenia, ChildhoodRela
Scleroderma, LimitedPgf
Scleroderma, LocalizedTgfb1
Scleroderma, SystemicVegfa
ScrapieStat1 , Stat3
Sebaceous Nevus Syndrome and HemimegalencephalyKras
SeizuresArid1b , Bad , Ccnd1 , Pld1 , Pten
SeminomaKras , Rb1 , Smad4 , Vegfa
Senior Loken SyndromeAkt3
SepsisBad , Mapk1 , Mapk3 , Pgf , Rela , Stat1 , Stat3 , Tgfb1
Sepsis-Associated EncephalopathyStat3
Septic PeritonitisPik3r1
Sezary SyndromeArid1a , Braf , Cdkn2a , Mapk1 , Pten , Rb1 , Smarca4 , Tp53
Shock, HemorrhagicBad , Bcl2l1 , Mapk1 , Rela
SHORT SyndromePik3r1
Single Upper Central IncisorShh
SinusitisMet
Sjogren's SyndromeTgfb1
Skin AbnormalitiesChuk
Skin DiseasesPten
Skin NeoplasmsAkt1 , Rela , Stat3 , Tgfb1 , Tgfbr1 , Tp53 , Vegfa
Sleep Apnea, ObstructiveRela
Small Cell Lung CarcinomaAkt1 , Egfr , Pik3ca , Pten , Rb1 , Smarca4 , Tp53
Small-For-Size SyndromeBad , Vegfa
Smith-Magenis SyndromeErbb2 , Stat3
Spina Bifida CysticaActl6a
Spinal Cord InjuriesAkt1 , Brca2 , Cdc42 , Egfr , Met , Rela , Shh , Tgfb1 , Tgfb2 , Tp53 , Vegfa
Spinal Cord Reperfusion InjuryBad
Spinal DysraphismGli1
SplenomegalyKras
Spondylitis, AnkylosingPgf
Spondylocostal Dysostosis 5Mapk3
Squamous Cell Carcinoma of the LungAkt1 , Braf , Cdkn2a , Egfr , Kras , Pik3ca , Pten , Tp53
Squamous Cell Carcinoma of the TongueEgfr , Met , Tp53
Status EpilepticusBcl2l1 , Ccnd1 , Pgf , Rela , Vegfa
Stevens-Johnson SyndromeRb1
Still's Disease, Adult-OnsetVegfa
Stomach DiseasesPten
Stomach NeoplasmsArid1a , Bcl2l1 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Gli3 , Kras , Mapk1 , Mapk3 , Mapk8 , Met , Pik3ca , Smad4 , Stat3 , Tgfa , Tp53
Stomach UlcerBad , Bcl2l1 , Egf , Vegfa
StrokeAkt1 , Bcl2l1 , Mapk8 , Pgf , Tgfa , Tgfb1 , Vegfa
Subarachnoid HemorrhageGli1 , Shh , Stat3
Substance Withdrawal SyndromeMapk1 , Mapk3
Substance-Related DisordersPten
Sudden Infant DeathVegfa
SyndactylyGli3
Syndactyly, Type IVShh
SyndromeRac2
Tachycardia, VentricularRaf1
Takenouchi-Kosaki SyndromeCdc42
Telangiectasia, Hereditary HemorrhagicSmad4
Telangiectasia, Hereditary Hemorrhagic, Type 1Tgfb1
Thoracic DiseasesIlk
Thoracic NeoplasmsSmarca4
Thrombocythemia, EssentialTgfb1
ThrombocytopeniaTgfb1
ThrombosisPik3cb
Thrombotic MicroangiopathiesVegfa
ThymomaCdkn2a , Pbrm1 , Tp53
Thymus NeoplasmsTp53
Thyroid Cancer, FollicularBraf , Pten
Thyroid Cancer, MedullaryKras
Thyroid cancer, papillaryBraf
Thyroid Carcinoma, AnaplasticTp53
Thyroid NeoplasmsBraf , Ccnd1 , Kras , Pten , Tp53
Thyroiditis, AutoimmuneLrp2
Tibial FracturesPgf
Tobacco Use DisorderEgfr
Tongue NeoplasmsCdkn2a , Stat3 , Tp53 , Vegfa , Vegfc
Tracheal StenosisTgfb1
Translocation, GeneticCdkn2a
Transplant RejectionIkbkb , Itga4
Trauma, Nervous SystemStat1
Trigeminal Nerve InjuriesTp53
Trigeminal NeuralgiaMapk1 , Mapk3 , Mapk8 , Mapk9
TrisomyCdkn2a
Tumor Predisposition SyndromeBrca2 , Cdk4 , Cdkn2a , Met , Pten , Smad4 , Tp53
Tympanic Membrane PerforationVegfa
UremiaTgfb1 , Tgfbr1
Ureteral ObstructionAkt1 , Shh , Tgfb1 , Tgfb2
Urethral ObstructionMapk1 , Tgfb1
Urinary Bladder NeoplasmsAkt1 , Arid1a , Bcl2l1 , Casp9 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Gli1 , Kras , Pten , Ralbp1 , Rb1 , Rela , Smad2 , Smad4 , Tgfbr1 , Tp53 , Vegfc , Vegfd
Urinary IncontinenceMapk1
Urogenital AbnormalitiesTgfb2
Urogenital NeoplasmsCdkn2a , Tp53
Urologic NeoplasmsCcnd1 , Erbb2 , Tp53 , Vegfa
UrticariaTgfb1
Uterine Cervical NeoplasmsAkt1 , Bcl2l1 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Kras , Mapk1 , Pik3ca , Pten , Rela , Smad2 , Smad4 , Stat3 , Tp53 , Vegfa
Uterine NeoplasmsBcl2l1 , Braf , Brca2 , Erbb2 , Kras , Map2k1 , Pik3ca , Pik3r1 , Pten , Rac1 , Smad3 , Tp53
Uveal MelanomaBrca2 , Vegfa
UveitisRela , Tgfb1
Uveitis, Autoimmune, ExperimentalStat3
Uveoretinitis, Autoimmune, ExperimentalStat3
VACTERL/VATER AssociationShh
VACTERL/VATER Association with HydrocephalusPten
VaricoceleCasp9
Ventilator-Induced Lung InjuryAkt1
Ventricular Premature ComplexesTgfb3
Ventricular RemodelingSmad2 , Smad3 , Tgfb1
Vitamin D DeficiencyLrp2
VitiligoTgfb1
von Hippel-Lindau DiseaseCcnd1
Vulvar Lichen SclerosusCdkn2a , Tp53
Vulvar NeoplasmsCdkn2a , Tp53
Wallerian DegenerationErbb2 , Pgf , Tgfb1 , Tgfb2
Weight GainPik3ca
Wet Macular DegenerationMapk8 , Vegfa
Wilms TumorBcl2l1 , Brca2 , Cdk4 , Cdkn2a , Erbb2 , Stat1 , Stat3 , Vegfc
Woolly Hair, Autosomal RecessiveRb1
Wounds and InjuriesEgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa
Wounds, PenetratingPgf
Xeroderma PigmentosumTp53
Zollinger-Ellison SyndromeEgf
Pathway Annotations Associated with Genes in the pancreatic cancer pathway
Pathway TermsGene Symbols
activin signaling pathwaySmad2 , Smad3
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Stat3 , Tcf7l2
adenosine signaling pathwayAkt1 , Bad , Braf , Cdc42 , Chuk , Ikbkb , Mapk1 , Mapk8 , Nfkb1 , Pik3ca
aldosterone signaling pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2 , Tgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered G1/S transition pathwayCdkn2a
altered Hedgehog signaling pathwayBoc , Gli1 , Gli3 , Lrp2 , Shh
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered integrin mediated signaling pathwayIlk , Itga11 , Itga4 , Itga9
altered p53 signaling pathwayTp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered scatter factor/hepatocyte growth factor signaling pathwayMet
altered SWI/SNF family mediated chromatin remodeling pathwayActl6a , Arid1a , Arid1b , Pbrm1 , Smarca4
altered transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expressionVegfa
altered vascular endothelial growth factor signaling pathway involving the main playersVegfa
altered Wnt signaling, canonical pathwayTcf7l2 , Wnt9a
Alzheimer disease pathwayBad , Casp9 , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBad , Bcl2l1 , Casp9 , Rac1 , Tp53
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2l1 , Casp9 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tp53
Arf family mediated signaling pathwayRac1
arrhythmogenic right ventricular cardiomyopathy pathwayItga11 , Itga4 , Itga9 , Tcf7l2
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Rela
basal cell carcinoma pathwayGli1 , Gli3 , Shh , Tcf7l2 , Tp53 , Wnt9a
bevacizumab pharmacodynamics pathwayVegfa
bladder cancer pathwayBraf , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Pgf , Raf1 , Rb1 , Tp53 , Vegfa , Vegfb , Vegfc , Vegfd
Bone morphogenetic proteins signaling pathwayMapk1 , Smad4
c-Jun N-terminal kinases MAPK signaling pathwayCdc42 , Mapk10 , Mapk8 , Mapk9 , Rac1
calcium/calcium-mediated signaling pathwayEgfr , Erbb2
cell cycle pathway, mitoticCcnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Rb1 , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tp53
cell-extracellular matrix signaling pathwayItga11 , Itga4 , Itga9
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Arhgef6 , Bad , Bcl2l1 , Braf , Brca2 , Casp9 , Ccnd1 , Cdc42 , Cdk4 , Cdk6 , Cdkn2a , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Ikbkb , Ikbkg , Jak1 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Rac2 , Rad51 , Raf1 , Rala , Ralb , Ralbp1 , Ralgds , Rb1 , Rela , Smad2 , Smad3 , Smad4 , Stat1 , Stat3 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa , Vegfb , Vegfc , Vegfd
cetuximab pharmacodynamics pathwayEgfr
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Rela , Stat1 , Stat3
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2l1 , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Chuk , E2f1 , E2f3 , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Rela , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Ralgds , Smad2 , Smad3 , Smad4 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
cortisol signaling pathwaySmarca4
cytokine mediated signaling pathwayEgf , Egfr , Met , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Vegfc , Vegfd
dilated cardiomyopathy pathwayItga11 , Itga4 , Itga9 , Tgfb1 , Tgfb2 , Tgfb3
doxorubicin pharmacokinetics pathwayRalbp1
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Cdc42 , Egf , Egfr , Pik3ca , Pik3r1 , Rac1
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5 , Rac1
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaIlk
endocytosis pathwayCdc42 , Egf , Egfr , Met , Pld1 , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Ilk , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Tcf7l2 , Tp53
Endoplasmic Reticulum-associated degradation pathwayMapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Cdc42 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Rac1 , Raf1
Entamoeba histolyca infection pathwayNfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tgfb1 , Tgfb2 , Tgfb3
ephrin - ephrin receptor bidirectional signaling axisCdc42 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1 , Pik3r5 , Rac1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Stat1 , Stat3 , Tgfa
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayBcl2l1 , Mapk8 , Nfkb1 , Pik3r1 , Stat1
ether lipid metabolic pathwayPld1
ether lipid metabolic pathwayPld1
FasL mediated signaling pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Cdc42 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Rac2 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Stat1
forkhead class A signaling pathwayAkt1 , Shh
G1 phase pathwayCcnd1 , Cdk4
G1/S transition pathwayCcnd1 , Cdk4 , Cdk6 , Cdkn2a , Rb1
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tgfa , Tp53
glutamate signaling pathwayMapk1 , Mapk3 , Pld1
glycerophospholipid metabolic pathwayPld1
glypican signaling pathwayMapk8 , Mapk9 , Shh , Smad2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr2 , Vegfa
gonadotropin-releasing hormone signaling pathwayCdc42 , Egfr , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pld1 , Raf1
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Raf1 , Stat1 , Stat3
Hedgehog signaling pathwayAkt1 , Boc , Gli1 , Gli3 , Lrp2 , Map2k1 , Pik3ca , Pik3r1 , Shh , Tgfb2 , Wnt9a
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Chuk , Egf , Egfr , Ikbkb , Ikbkg , Jak1 , Kras , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Stat1 , Stat3 , Tp53
histone modification pathwayPbrm1 , Smarca4
homologous recombination pathway of double-strand break repairBrca2 , Rad51
Huntington disease pathwayCasp9 , Tp53
hypertrophic cardiomyopathy pathwayItga11 , Itga4 , Itga9 , Tgfb1 , Tgfb2 , Tgfb3
hypoxia inducible factor pathwayAkt1 , Smad3 , Smad4 , Vegfa
inflammatory response pathwayMapk8
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Casp9 , Ikbkb , Jak1 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Stat1
INO80 family mediated chromatin remodeling pathwayActl6a
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Rac1
insulin secretion pathwayCdc42
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ikbkb , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
insulin-like growth factor signaling pathwayAkt1 , Bad , Pik3ca , Pik3r1 , Raf1
integrin mediated signaling pathwayIlk , Itga11 , Itga4 , Itga9
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Rela
Interleukin-10 signaling pathwayJak1 , Stat1 , Stat3
interleukin-12 signaling pathwayNfkb1 , Rela , Stat1 , Stat3
interleukin-2 signaling pathwayJak1 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3r1 , Raf1 , Stat1 , Stat3
interleukin-23 signaling pathwayNfkb1 , Pik3ca , Pik3r1 , Rela , Stat1 , Stat3
interleukin-27 signaling pathwayJak1 , Stat1 , Stat3 , Tgfb1
interleukin-3 signaling pathwayBcl2l1 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Jak1 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Jak1 , Pik3ca , Pik3r1 , Rac1 , Stat1 , Stat3
intrinsic apoptotic pathwayBad , Bcl2l1 , Casp9
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Ccnd1 , Jak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3
Leishmania infection pathwayItga4 , Jak1 , Mapk1 , Mapk3 , Nfkb1 , Rela , Stat1 , Tgfb1 , Tgfb2 , Tgfb3
leptin system pathwayStat3
long term depressionBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
long term potentiationBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
measles infection pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Cdk4 , Cdk6 , Chuk , Jak1 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Stat3 , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tp53
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Chuk , Egf , Egfr , Erbb2 , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Rac1 , Rac2 , Raf1 , Rela , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Ikbkb , Map2k1 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Jak1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Raf1 , Rela , Stat1 , Tgfb1 , Tgfb2 , Tgfb3
myocarditis pathwayCasp9 , Ccnd1 , Rac1 , Rac2
N-cadherin signaling pathwayCdc42 , Mapk8 , Pik3ca , Pik3r1 , Rac1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdc42 , Ikbkb , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rela , Tp53
NOD-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Rela
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tgfa , Tp53
Non-Stat, Jak dependent pathwayJak1
Notch signaling pathwayCcnd1
nuclear factor kappa B signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb , Pten
p38 MAPK signaling pathwayCdc42 , Rac1
p53 signaling pathwayAkt1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Mapk8 , Mapk9 , Pten , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayActl6a , Akt1 , Akt2 , Akt3 , Arhgef6 , Arid1a , Arid1b , Bad , Bcl2l1 , Boc , Braf , Brca2 , Casp9 , Ccnd1 , Cdc42 , Cdk4 , Cdk6 , Cdkn2a , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Gli1 , Gli3 , Ikbkb , Ikbkg , Ilk , Itga11 , Itga4 , Itga9 , Jak1 , Kras , Lrp2 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Met , Nfkb1 , Pbrm1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Pten , Rac1 , Rac2 , Rad51 , Raf1 , Rala , Ralb , Ralbp1 , Ralgds , Rb1 , Rela , Shh , Smad2 , Smad3 , Smad4 , Smarca4 , Stat1 , Stat3 , Tcf7l2 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa , Vegfb , Vegfc , Vegfd , Wnt9a
panitumumab pharmacodynamics pathwayEgfr
Parkinson disease pathwayCasp9
phagocytosis pathwayRac1
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rac1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1 , Pten
Plasmodium infection pathwayMet , Tgfb1 , Tgfb2 , Tgfb3
platelet-derived growth factor signaling pathwayBraf , Jak1 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rac1 , Raf1 , Stat1 , Stat3
primary immunodeficiency disease pathwayIkbkg
prion diseases pathwayMap2k1 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Rela , Tcf7l2 , Tgfa , Tp53
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Mapk8 , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pbrm1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb , Vegfc , Vegfd
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk10 , Mapk8 , Mapk9 , Nfkb1 , Rela
rheumatoid arthritis disease pathwayPgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb
Rho/Rac/Cdc42 mediated signaling pathwayCdc42 , Mapk8 , Rac1
RNA polymerase III transcription pathwayRb1
S phase pathwayCcnd1 , Cdk4
scatter factor/hepatocyte growth factor signaling pathwayMet , Pik3r1
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Chuk , E2f1 , E2f3 , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rb1 , Rela , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Cdc42 , Mapk1 , Mapk3 , Mapk8 , Rac1 , Vegfa
SWI/SNF family mediated chromatin remodeling pathwayActl6a , Arid1a , Arid1b , Pbrm1 , Smarca4
syndecan signaling pathwayEgfr , Mapk1 , Mapk3 , Mapk8 , Rac1 , Tgfb1
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cdc42 , Cdk4 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Tcf7l2 , Tp53
tioguanine pharmacodynamics pathwayRac1
titanium dioxide nanoparticle response pathwayTp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Stat1
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2l1 , Casp9 , Chuk , Ikbkb , Ikbkg , Jak1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Stat3 , Tgfb1 , Tgfb2 , Tgfb3
Trail mediated signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
trastuzumab pharmacodynamics pathwayEgfr
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
tumor necrosis factor mediated signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela , Stat1
type 2 diabetes mellitus pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Jak1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Stat1 , Stat3
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Cdc42 , Kras , Map2k1 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
vinblastine pharmacodynamics pathwayRalbp1 , Tp53
vincristine pharmacodynamics pathwayRalbp1 , Tp53
vindesine pharmacodynamics pathwayRalbp1 , Tp53
vinorelbine pharmacodynamics pathwayRalbp1 , Tp53
Wnt signaling pathwayCcnd1 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Rac2 , Smad2 , Smad3 , Smad4 , Tcf7l2 , Tp53 , Wnt9a
Wnt signaling, canonical pathwaySmarca4 , Tcf7l2 , Wnt9a
Wnt signaling, non-canonical pathwayCdc42 , Mapk10 , Mapk8 , Mapk9 , Rac1
Wnt signaling, the planar cell polarity pathwayRac1
Phenotype Annotations Associated with Genes in the pancreatic cancer pathway

References Associated with the pancreatic cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: