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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3033
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad4
Name: SMAD family member 4
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad4increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of SMAD4 mRNA; Carbon Tetrachloride results in increased expression of SMAD4 proteinPMID:16570350 PMID:17334410 PMID:25150141
Smad4multiple interactionsEXP 6480464CTDFR 167653 inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD4 protein]PMID:17334410
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