RGD Reference Report - Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. - Rat Genome Database

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Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression.

Authors: Horvath, LG  Henshall, SM  Kench, JG  Turner, JJ  Golovsky, D  Brenner, PC  O'Neill, GF  Kooner, R  Stricker, PD  Grygiel, JJ  Sutherland, RL 
Citation: Horvath LG, etal., Prostate. 2004 May 15;59(3):234-42.
RGD ID: 2299981
Pubmed: PMID:15042598   (View Abstract at PubMed)
DOI: DOI:10.1002/pros.10361   (Journal Full-text)

BACKGROUND: The role of the bone morphogenetic protein (BMP) pathway in prostate cancer (PC) is unclear. This study aimed to characterize aspects of the BMP pathway in PC by assessing BMP2, Smad8, and Smad4 expression in normal, hyperplastic, and malignant prostate tissue, and to correlate findings with progression to PC. METHODS: Radical prostatectomy (RP) specimens from 74 patients with clinically localized PC (median follow-up 51 months, range 15-152), 44 benign prostatic hypertrophy (BPH) lesions, and 4 normal prostates (NPs) were assessed for BMP2, Smad8, and Smad4 expression using immunohistochemistry. RESULTS: Both BMP2 (P < 0.001) and nuclear Smad4 (P < 0.0001) expression were significantly decreased in PC compared to benign prostate tissue. Nuclear Smad8 was present in normal/benign prostate tissue but absent in PC and adjacent hyperplasia. Furthermore, loss of BMP2 (P < 0.001) and decreased nuclear Smad4 (P = 0.05) expression correlated with increasing Gleason score. CONCLUSIONS: These data suggest that decreased BMP2, nuclear smad8 and nuclear Smad4 expression are associated with the progression to PC, and in particular loss of BMP2 and Smad4 are related to progression to a more aggressive phenotype.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
prostate cancer disease_progressionIEP 2299981 RGD 
prostate cancer disease_progressionISOBMP2 (Homo sapiens)2299981; 2299981 RGD 
prostate cancer  IEP 2299981protein:altered localizationRGD 
prostate cancer  ISOSMAD9 (Homo sapiens)2299981; 2299981protein:altered localizationRGD 
Prostatic Neoplasms disease_progressionIEP 2299981 RGD 
Prostatic Neoplasms disease_progressionISOSMAD4 (Homo sapiens)2299981; 2299981 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bmp2  (bone morphogenetic protein 2)
Smad4  (SMAD family member 4)
Smad9  (SMAD family member 9)

Genes (Mus musculus)
Bmp2  (bone morphogenetic protein 2)
Smad4  (SMAD family member 4)
Smad9  (SMAD family member 9)

Genes (Homo sapiens)
BMP2  (bone morphogenetic protein 2)
SMAD4  (SMAD family member 4)
SMAD9  (SMAD family member 9)


Additional Information