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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3033
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad4
Name: SMAD family member 4
Acc ID: CHEBI:5262
Term: galangin
Definition: A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells.
Chemical ID: MESH:C037032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad4increases expressionISOSMAD4 (Homo sapiens)6480464CTDgalangin results in increased expression of SMAD4 mRNAPMID:25268046
Smad4multiple interactionsISOSMAD4 (Homo sapiens)6480464CTDSMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG12 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG16L1 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG3 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of BECN1 protein]PMID:25268046
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