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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3033
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad4
Name: SMAD family member 4
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad4affects localizationISOSmad4 (Mus musculus)6480464CTDEthanol affects the localization of SMAD4 proteinPMID:24746831
Smad4decreases expressionISOSmad4 (Mus musculus)6480464CTDEthanol results in decreased expression of SMAD4 mRNA; Ethanol results in decreased expression of SMAD4 proteinPMID:24746831
Smad4increases expressionISOSMAD4 (Homo sapiens)6480464CTDEthanol results in increased expression of SMAD4 mRNAPMID:23378141
Smad4multiple interactionsISOSMAD4 (Homo sapiens)6480464CTDBMP6 protein inhibits the reaction [Ethanol results in decreased expression of SMAD4 mRNA]PMID:24746831
Smad4multiple interactionsISOSmad4 (Mus musculus)6480464CTDBMP6 protein affects the reaction [Ethanol affects the localization of SMAD4 protein]; BMP6 protein affects the reaction [Ethanol inhibits the reaction [SMAD4 protein binds to HAMP promoter]]; Ethanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of SMAD4 protein]; Ethanol inhibits the reaction [SMAD4 protein binds to HAMP promoter]; Quercetin affects the reaction [Ethanol affects the localization of SMAD4 protein]; Quercetin inhibits the reaction [Ethanol inhibits the reaction [SMAD4 protein binds to HAMP promoter]]; Quercetin inhibits the reaction [Ethanol results in decreased expression of SMAD4 mRNA]; Quercetin inhibits the reaction [Ethanol results in decreased expression of SMAD4 protein]PMID:24746831
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