SMAD4 (SMAD family member 4) - Rat Genome Database

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Gene: SMAD4 (SMAD family member 4) Pan paniscus
Analyze
Symbol: SMAD4
Name: SMAD family member 4
RGD ID: 11952749
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); filamin binding (ortholog); INVOLVED IN adrenal gland development (ortholog); anatomical structure morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; Bone morphogenetic proteins signaling pathway; colorectal cancer pathway; ASSOCIATED WITH Acro-Osteolysis (ortholog); aortic disease (ortholog); brachydactyly (ortholog); FOUND IN heteromeric SMAD protein complex (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mothers against decapentaplegic homolog 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21768,549,261 - 68,603,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11854,241,866 - 54,296,559 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01844,402,112 - 44,456,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11847,692,311 - 47,802,530 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1847,764,568 - 47,797,359 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acro-Osteolysis  (ISO)
aortic disease  (ISO)
brachydactyly  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
cervical cancer  (ISO)
cholangiocarcinoma  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cicatrix  (ISO)
cognitive disorder  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal adenoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Craniofacial Abnormalities  (ISO)
Cronkhite-Canada syndrome  (ISO)
Deafness  (ISO)
endometrial carcinoma  (ISO)
esophageal carcinoma  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Colitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
gallbladder cancer  (ISO)
Gallstones  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal system cancer  (ISO)
genetic disease  (ISO)
Growth Mental Deficiency Syndrome of Myhre  (ISO)
head and neck squamous cell carcinoma  (ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary hemorrhagic telangiectasia  (ISO)
Hereditary Hemorrhagic Telangiectasia, Type 1  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Heterotopic Ossification  (ISO)
Human Viral Hepatitis  (ISO)
Hypoglossal Nerve Injuries  (ISO)
intellectual disability  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
invasive ductal carcinoma  (ISO)
juvenile polyposis syndrome  (ISO)
juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome  (ISO)
Liver Metastasis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lymphatic Metastasis  (ISO)
Lynch syndrome  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
Microphthalmia, Cataracts, and Iris Abnormalities  (ISO)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
Odontogenic Cysts  (ISO)
osteogenesis imperfecta  (ISO)
ovarian cancer  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
Parasitic Liver Diseases  (ISO)
pre-malignant neoplasm  (ISO)
Primary Pulmonary Hypertension, 1  (ISO)
prostate adenocarcinoma  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
seminoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
thoracic aortic aneurysm  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
anatomical structure morphogenesis  (IEA,ISO)
anterior/posterior pattern specification  (IEA,ISO)
atrioventricular canal development  (IEA)
atrioventricular valve formation  (IEA)
axon guidance  (IEA,ISO)
BMP signaling pathway  (IEA)
brainstem development  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac septum development  (IEA)
cell differentiation  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to glucose stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (IEA)
developmental growth  (IEA,ISO)
DNA-templated transcription  (IEA)
embryonic digit morphogenesis  (IEA)
endocardial cell differentiation  (IEA)
endoderm development  (IEA,ISO)
endothelial cell activation  (IEA)
epithelial cell migration  (IEA)
epithelial to mesenchymal transition  (IEA)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IEA)
ERK1 and ERK2 cascade  (ISO)
extrinsic apoptotic signaling pathway  (IEA)
female gonad development  (IEA,ISO)
female gonad morphogenesis  (IEA,ISO)
formation of anatomical boundary  (IEA,ISO)
gastrulation  (IEA,ISO)
gastrulation with mouth forming second  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
interleukin-6-mediated signaling pathway  (IEA)
intracellular iron ion homeostasis  (IEA)
intracellular signal transduction  (IEA)
kidney development  (IEA,ISO)
left ventricular cardiac muscle tissue morphogenesis  (IEA)
male gonad development  (IEA,ISO)
mesendoderm development  (IEA,ISO)
mesoderm development  (IEA,ISO)
metanephric mesenchyme morphogenesis  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cardiac muscle hypertrophy  (IEA)
negative regulation of cardiac myofibril assembly  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of ERK1 and ERK2 cascade  (IEA)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
nephrogenic mesenchyme morphogenesis  (IEA)
neural crest cell differentiation  (IEA,ISO)
neuron fate commitment  (IEA,ISO)
neuron fate specification  (IEA)
osteoblast differentiation  (ISO)
outflow tract septum morphogenesis  (IEA)
ovarian follicle development  (IEA,ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell proliferation involved in heart valve morphogenesis  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of extracellular matrix assembly  (IEA)
positive regulation of follicle-stimulating hormone secretion  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of luteinizing hormone secretion  (IEA,ISO)
positive regulation of miRNA transcription  (IEA)
positive regulation of SMAD protein signal transduction  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IEA)
regulation of cell population proliferation  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (IEA)
regulation of hair follicle development  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of transforming growth factor beta receptor signaling pathway  (IEA)
regulation of transforming growth factor beta2 production  (IEA)
response to hypoxia  (IEA)
response to transforming growth factor beta  (IEA)
sebaceous gland development  (IEA,ISO)
secondary palate development  (IEA)
seminiferous tubule development  (IEA,ISO)
single fertilization  (IEA,ISO)
SMAD protein signal transduction  (IEA,ISO)
somite rostral/caudal axis specification  (IEA,ISO)
spermatogenesis  (IEA,ISO)
tissue morphogenesis  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)
uterus development  (IEA,ISO)
ventricular septum morphogenesis  (IEA)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SMAD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21768,549,261 - 68,603,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11854,241,866 - 54,296,559 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01844,402,112 - 44,456,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11847,692,311 - 47,802,530 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1847,764,568 - 47,797,359 (+)Ensemblpanpan1.1panPan2
SMAD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381851,030,213 - 51,085,042 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1851,028,528 - 51,085,045 (+)EnsemblGRCh38hg38GRCh38
GRCh371848,556,583 - 48,611,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361846,810,611 - 46,860,145 (+)NCBINCBI36Build 36hg18NCBI36
Build 341846,810,610 - 46,860,144NCBI
Celera1845,413,367 - 45,468,195 (+)NCBICelera
Cytogenetic Map18q21.2NCBI
HuRef1845,411,927 - 45,466,923 (+)NCBIHuRef
CHM1_11848,551,997 - 48,606,836 (+)NCBICHM1_1
T2T-CHM13v2.01851,231,926 - 51,286,759 (+)NCBIT2T-CHM13v2.0
Smad4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391873,767,861 - 73,836,862 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1873,772,080 - 73,836,851 (-)EnsemblGRCm39 Ensembl
GRCm381873,634,790 - 73,703,791 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1873,639,009 - 73,703,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv371873,798,667 - 73,863,395 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361873,764,382 - 73,829,110 (-)NCBIMGSCv36mm8
Celera1874,884,056 - 74,923,073 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1849.51NCBI
Smad4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81869,518,988 - 69,549,684 (-)NCBIGRCr8
mRatBN7.21867,243,742 - 67,274,438 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1867,243,742 - 67,274,438 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1869,351,818 - 69,382,528 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01870,026,538 - 70,057,217 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01867,891,801 - 67,922,479 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01869,626,682 - 69,657,373 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1869,627,757 - 69,671,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01868,773,326 - 68,802,354 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41870,432,705 - 70,461,541 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11870,504,785 - 70,534,814 (-)NCBI
Celera1865,246,042 - 65,276,480 (-)NCBICelera
Cytogenetic Map18q12.2NCBI
Smad4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540235,961,165 - 35,994,538 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540235,956,080 - 36,001,746 (+)NCBIChiLan1.0ChiLan1.0
SMAD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,875,989 - 23,930,027 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,882,139 - 23,969,405 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha124,868,005 - 24,956,178 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,767,402 - 23,821,366 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,772,519 - 23,821,180 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,833,038 - 23,921,205 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,719,264 - 23,807,404 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,987,158 - 24,041,139 (-)NCBIUU_Cfam_GSD_1.0
Smad4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494437,008,523 - 37,038,961 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649712,249,140 - 12,278,123 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649712,242,869 - 12,278,012 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1100,589,850 - 100,628,029 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11100,521,843 - 100,633,501 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21110,456,997 - 110,568,659 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11829,894,157 - 29,951,445 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1829,897,621 - 29,934,478 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660504,018,900 - 4,079,370 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477814,570,348 - 14,630,325 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477814,570,025 - 14,629,950 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000032107   ⟹   ENSPPAP00000009464
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1847,764,568 - 47,797,359 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032121   ⟹   ENSPPAP00000009478
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1847,764,568 - 47,796,024 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032122   ⟹   ENSPPAP00000009479
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1847,764,568 - 47,796,024 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032123   ⟹   ENSPPAP00000009480
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1847,764,568 - 47,796,024 (+)Ensembl
RefSeq Acc Id: XM_034943721   ⟹   XP_034799612
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21768,549,261 - 68,603,954 (+)NCBI
NHGRI_mPanPan11854,241,866 - 54,296,559 (+)NCBI
Mhudiblu_PPA_v01844,402,112 - 44,456,779 (+)NCBI
RefSeq Acc Id: XM_034943722   ⟹   XP_034799613
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21768,549,408 - 68,603,954 (+)NCBI
NHGRI_mPanPan11854,242,126 - 54,296,559 (+)NCBI
Mhudiblu_PPA_v01844,402,374 - 44,451,849 (+)NCBI
RefSeq Acc Id: XM_055102491   ⟹   XP_054958466
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21768,549,261 - 68,596,391 (+)NCBI
NHGRI_mPanPan11854,241,866 - 54,288,996 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034799612 (Get FASTA)   NCBI Sequence Viewer  
  XP_034799613 (Get FASTA)   NCBI Sequence Viewer  
  XP_054958466 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000009464.1
  ENSPPAP00000009478.1
  ENSPPAP00000009479.1
  ENSPPAP00000009480.1
Reference Protein Sequences
RefSeq Acc Id: XP_034799612   ⟸   XM_034943721
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A0M1 (UniProtKB/TrEMBL),   A0A2R9A2G1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034799613   ⟸   XM_034943722
- Peptide Label: isoform X3
- UniProtKB: A0A2R9A2H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000009480   ⟸   ENSPPAT00000032123
RefSeq Acc Id: ENSPPAP00000009479   ⟸   ENSPPAT00000032122
RefSeq Acc Id: ENSPPAP00000009478   ⟸   ENSPPAT00000032121
RefSeq Acc Id: ENSPPAP00000009464   ⟸   ENSPPAT00000032107
RefSeq Acc Id: XP_054958466   ⟸   XM_055102491
- Peptide Label: isoform X2
Protein Domains
MH1   MH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000027913 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032107.1 UniProtKB/TrEMBL
  ENSPPAT00000032121.1 UniProtKB/TrEMBL
  ENSPPAT00000032122.1 UniProtKB/TrEMBL
  ENSPPAT00000032123.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/TrEMBL
NCBI Gene SMAD4 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4 UniProtKB/TrEMBL
  PTHR13703 UniProtKB/TrEMBL
Pfam MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
PROSITE MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
SMART DWA UniProtKB/TrEMBL
  DWB UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/TrEMBL
  SSF56366 UniProtKB/TrEMBL
UniProt A0A2R8ZWW9_PANPA UniProtKB/TrEMBL
  A0A2R9A0M1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A2G1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A2H7 ENTREZGENE, UniProtKB/TrEMBL