HYPOXIA INDUCIBLE FACTOR PATHWAY (PW:0000360)

View Ontology Report

Description

Maintaining adequate levels of oxygen is crucial for the proper functioning of cells and tissues as either excess or deficiency of oxygen can have profound pathological consequences. Oxygen is the terminal electron acceptor of the respiratory chain - the electron transport pathway (ETC) whose resulting electrochemical proton gradient drives the synthesis of ATP. ETC also produces reactive oxygen species (ROS) and it is thought that the switch to glycolysis for ATP production when oxygen levels b

Pathway Diagram:

Ariadne Genomics Inc. Crebbp N-OH P-OH EP300 Hif1a-O2 Egln1 Egln2 Egln3 Hif1a+O2 Hif target genes Tceb1 recruited complex Hif-alpha ubiquitination, proteasomal degradation Arnt Hif1a+O2 ---- Os9 Egln1 ---- Os9 Os9 Hif1a+O2 ---- Vhl Hif1an ---> Hif1a+O2 Gnb2l1 ---- Hif1a+O2 Hif1an Hif1a+O2 ---| Crebbp Hif1a+O2 ---| EP300 Hif1a+O2 ---- Sat2 Sat2 Vhl Sat2 ---- Vhl Hif1a+O2 ---- Sat1 Tceb1 Tceb1 ---- Vhl Sat2 ---- Tceb1 Sat1 Gnb2l1 Gnb2l1 ---- Sat1 Gnb2l1 ---- Tceb1 Tceb1 ---- Tceb1 recruited complex Epas1 Hif3a Arnt2 Hif1a-O2 ---> Hif target genes Egln1 ---> Hif1a+O2
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Genes in Pathway:

show annotations for term's descendants       view all columns
hypoxia inducible factor pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6484113
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6484113
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:6484113
G Adora2a adenosine A2a receptor JBrowse link 20 14,265,251 14,282,873 RGD:6484113
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Aldoa aldolase, fructose-bisphosphate A JBrowse link 1 198,228,387 198,233,988 RGD:6484113
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:6484113
G Arnt aryl hydrocarbon receptor nuclear translocator JBrowse link 2 196,594,178 196,651,486 RGD:6483352
RGD:6484113
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 JBrowse link 1 146,399,217 146,556,437 RGD:6483352
G Bhlhe40 basic helix-loop-helix family, member e40 JBrowse link 4 140,703,619 140,709,319 RGD:6484113
G Bhlhe41 basic helix-loop-helix family, member e41 JBrowse link 4 180,230,742 180,235,138 RGD:6484113
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:6484113
G Car9 carbonic anhydrase 9 JBrowse link 5 59,008,277 59,015,535 RGD:6484113
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 JBrowse link 1 12,823,363 12,825,806 RGD:6484113
G Cops5 COP9 signalosome subunit 5 JBrowse link 5 8,876,090 8,894,345 RGD:6484113
G Cp ceruloplasmin JBrowse link 2 104,744,249 104,803,034 RGD:6484113
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6484113
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6483358
RGD:6483503
RGD:6484113
G Cul2 cullin 2 JBrowse link 17 56,952,480 56,992,716 RGD:6483358
G Cxcl12 C-X-C motif chemokine ligand 12 JBrowse link 4 149,261,044 149,273,891 RGD:6484113
G Cxcr4 C-X-C motif chemokine receptor 4 JBrowse link 13 45,314,952 45,318,856 RGD:6484113
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6484113
G Efna1 ephrin A1 JBrowse link 2 188,588,808 188,596,156 RGD:6484113
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:727754
RGD:1334466
RGD:6483358
RGD:6483503
RGD:6484113
G Egln2 egl-9 family hypoxia-inducible factor 2 JBrowse link 1 83,969,456 83,977,665 RGD:6483503
RGD:6484113
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 6 75,050,329 75,075,795 RGD:6483503
RGD:6484113
G Eif3el1 eukaryotic translation initiation factor 3, subunit E-like 1 JBrowse link 13 100,129,757 100,162,596 RGD:6484113
G Elk1 ELK1, ETS transcription factor JBrowse link X 1,287,875 1,304,822 RGD:6484113
G Elob elongin B JBrowse link 10 13,163,032 13,168,217 RGD:6483358
RGD:6484113
G Eloc elongin C JBrowse link 5 2,042,991 2,059,357 RGD:6483358
RGD:6484113
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:6484113
G Eno1 enolase 1 JBrowse link 5 167,288,223 167,299,610 RGD:6484113
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6483358
RGD:6483503
RGD:6484113
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:6483352
RGD:6483503
RGD:6484113
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:6484113
G Ets1 ETS proto-oncogene 1, transcription factor JBrowse link 8 33,756,634 33,879,625 RGD:6484113
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:6484113
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:6484113
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6484113
G Furin furin (paired basic amino acid cleaving enzyme) JBrowse link 1 142,185,092 142,198,167 RGD:6484113
G Fxn frataxin JBrowse link 1 242,123,975 242,152,834 RGD:6484113
G Gata2 GATA binding protein 2 JBrowse link 4 120,129,028 120,142,490 RGD:6484113
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:6484113
G Hdac7 histone deacetylase 7 JBrowse link 7 139,280,396 139,319,108 RGD:6484113
G Hif1a hypoxia inducible factor 1 alpha subunit JBrowse link 6 96,810,868 96,856,303 RGD:628389
RGD:1580561
RGD:2301848
RGD:6483352
RGD:6483503
RGD:6484113
G Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor JBrowse link 1 264,309,214 264,319,269 RGD:1334466
RGD:6483352
RGD:6483358
RGD:6484113
G Hif3a hypoxia inducible factor 3, alpha subunit JBrowse link 1 78,976,318 78,997,869 RGD:68201
RGD:6483352
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:6484113
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6484113
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6484113
G Hnf4a hepatocyte nuclear factor 4, alpha JBrowse link 3 159,902,441 159,965,003 RGD:6484113
G Id2 inhibitor of DNA binding 2, HLH protein JBrowse link 6 44,360,077 44,361,908 RGD:6484113
G Igfbp1 insulin-like growth factor binding protein 1 JBrowse link 14 87,448,716 87,453,783 RGD:6484113
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:6484113
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6484113
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6484113
G Ldha lactate dehydrogenase A JBrowse link 1 102,900,288 102,909,713 RGD:6484113
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6484113
G Mcl1 MCL1, BCL2 family apoptosis regulator JBrowse link 2 197,786,212 197,788,992 RGD:6484113
G Mmp14 matrix metallopeptidase 14 JBrowse link 15 33,074,441 33,083,666 RGD:6484113
G Ncoa1 nuclear receptor coactivator 1 JBrowse link 6 28,677,563 28,931,844 RGD:6484113
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:6484113
G Ndrg1 N-myc downstream regulated 1 JBrowse link 7 107,734,326 107,775,701 RGD:6484113
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6484113
G Npm1 nucleophosmin 1 JBrowse link 10 18,080,949 18,091,062 RGD:6484113
G Nt5e 5' nucleotidase, ecto JBrowse link 8 95,969,002 96,012,733 RGD:6484113
G Os9 OS9, endoplasmic reticulum lectin JBrowse link 7 70,378,625 70,407,135 RGD:6483358
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 JBrowse link 17 70,632,778 70,713,736 RGD:6484113
G Pfkl phosphofructokinase, liver type JBrowse link 20 11,393,860 11,415,889 RGD:6484113
G Pgk1 phosphoglycerate kinase 1 JBrowse link X 77,263,399 77,279,373 RGD:6484113
G Pgm1 phosphoglucomutase 1 JBrowse link 5 118,743,632 118,803,055 RGD:6484113
G Pkm pyruvate kinase, muscle JBrowse link 8 64,480,963 64,502,957 RGD:6484113
G Plin2 perilipin 2 JBrowse link 5 104,984,413 105,010,863 RGD:6484113
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:6484113
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:6483358
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:6483358
G Sat1 spermidine/spermine N1-acetyl transferase 1 JBrowse link X 43,626,480 43,629,767 RGD:6483358
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 JBrowse link 10 56,227,703 56,229,796 RGD:6483358
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6484113
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:6484113
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6484113
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:6484113
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:6484113
G Sp1 Sp1 transcription factor JBrowse link 7 144,014,173 144,044,635 RGD:6484113
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:6484113
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:6484113
G Tff3 trefoil factor 3 JBrowse link 20 9,850,800 9,855,481 RGD:6484113
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:6484113
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:6484113
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6484113
G Vhl von Hippel-Lindau tumor suppressor JBrowse link 4 145,580,869 145,587,835 RGD:1358257
RGD:1580561
RGD:6483358
RGD:6484113
altered hypoxia inducible factor pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vhl von Hippel-Lindau tumor suppressor JBrowse link 4 145,580,869 145,587,835 RGD:6907133

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeN-OHhydroxylated asparagine
Small MoleculeP-OHhydroxylated prolines
ComplexTceb1 recruited complexProtein complec recruited by the VHL bound Tceb1/Elongin C
Gene GroupHif target genesselected Hif target genes

Pathway Gene Annotations

Disease Annotations Associated with Genes in the hypoxia inducible factor pathway
Disease TermsGene Symbols
Abnormalities, MultipleCrebbp
Abortion, SpontaneousArnt , Igfbp1 , Tfrc
AcidosisAdm
Acro-OsteolysisSmad4
AcrocephalosyndactyliaTwist1
Acute Chest SyndromeHmox1 , Vegfa
Acute Coronary SyndromeEno1
Acute Kidney InjuryEdn1 , Egln1 , Egln3 , Epas1 , Epo , Hif1a , Hmox1 , Igfbp1 , Nos2 , Tff3 , Vegfa
Acute Lung InjuryEdn1 , Flt1 , Hmox1 , Itgb2 , Kdr , Nos2 , Serpine1 , Vegfa
Acute-Phase ReactionEpo , Hif1a , Tf , Tfrc
AdenocarcinomaEno1 , Hmox1 , Kdr , Mmp14 , Vegfa
Adenocarcinoma of EsophagusSmad4
Adenocarcinoma of LungAkt1 , Aldoa , Crebbp , Eno1 , Ep300 , Smad4 , Tf
ADENOCARCINOMA OF STOMACHAkt1 , Crebbp , Smad4
Adenocarcinoma, ColonTert
Adenocarcinoma, ProstaticAkt1 , Smad4 , Tert
AdenomaAbcg2 , Vhl
Adenomatous Polyposis ColiAkt1
Adrenocortical CarcinomaAbcb1a , Tert
AdrenoleukodystrophyHmox1
AIDS Dementia ComplexEpo
AlbuminuriaAdm , Cp , Edn1 , Epo , Serpine1
AlcoholismTf
Alopecia AreataHdac7
Altitude SicknessHmox1
Alveolitis, Extrinsic AllergicNos2 , Vegfa
Alzheimer DiseaseAkt1 , Crebbp , Elk1 , Eno1 , Ep300 , Epo , Hif1a , Hmox1 , Lep , Nos2 , Slc2a1 , Tf , Vegfa
Amphetamine-Related DisordersAdora2a , Akt1 , Fos , Pou5f1
Amyotrophic Lateral SclerosisAkt1 , Epo , Kdr , Nos2 , Slc11a2 , Vegfa
Amyotrophic Lateral Sclerosis 1Crebbp , Fos
AnaplasiaCar9 , Hif1a
Anastomotic LeakEpo
AnemiaEpo , Gata2 , Hk1 , Slc11a2 , Tf
Anemia, AplasticGata2 , Tert
Anemia, HemolyticEpo , Hmox1 , Pgk1
Anemia, Hemolytic, Congenital NonspherocyticHk1
Anemia, HypochromicSlc11a2
Anemia, Hypochromic MicrocyticTf , Tfrc
Anemia, Hypochromic Microcytic, with Iron OverloadSlc11a2
Anemia, Iron-DeficiencySlc11a2 , Tf , Tfrc
Anemia, RefractoryTert
Anemia, Refractory, with Excess of BlastsTert
Anemia, Sickle CellHk1 , Hmox1
Anemia, SideroblasticTfrc
AneurysmSmad3
Aneurysm, DissectingSmad3
Angina, UnstableAkt1 , Edn1
AnoxiaCar9
Anterior Wall Myocardial InfarctionEdn1
Anthracycline-induced CardiotoxicityAbcb1a
Anti-Glomerular Basement Membrane DiseaseCxcl12 , Mmp14 , Nos2
Anxiety DisordersAdora2a , Fos
Aortic AneurysmSerpine1 , Smad3
Aortic Aneurysm, AbdominalAdm , Hmox1 , Mmp14 , Nos2 , Serpine1
Aortic Aneurysm, ThoracicMmp14 , Smad3
Aortic DiseasesSmad4
Aortic RemodelingSerpine1
Aortic Valve, Calcification ofAkt1
Arenaviridae InfectionsTfrc
Arrhythmias, CardiacAdm , Edn1
Arsenic PoisoningId2 , Pfkfb3
Arterial ThrombosisHif1a , Serpine1
ArteriosclerosisFurin , Hmox1 , Kdr , Mmp14
Arteriovenous FistulaVegfa
Arteriovenous MalformationsEng
Arthritis, ExperimentalAbcb1a , Abcg2 , Akt1 , Cp , Edn1 , Flt1 , Hif1a , Itgb2 , Lep , Nos2 , Vegfa
Arthritis, JuvenileCxcr4 , Fos , Jun , Smad3
Arthritis, PsoriaticNos2
Arthritis, RheumatoidAbcb1a , Abcg2 , Adora2a , Cp , Cxcr4 , Edn1 , Eno1 , Epas1 , Hif1a , Vegfa
AsbestosisNos2
AsphyxiaHif1a , Jun
AsthmaAbcb1a , Adora2a , Edn1 , Hif1a , Hmox1 , Kdr , Lep , Nos2 , Serpine1 , Vegfa
AstrocytomaAkt1 , Hif1a , Ndrg1
AtaxiaCp , Slc2a1
AtherosclerosisAkt1 , Edn1 , Egln1 , Kdr , Nos2 , Serpine1 , Vegfa
Atrial FibrillationEdn1 , Flt1 , Hif1a , Vegfa
Atrial Septal Defect 8Cited2
Attention Deficit Disorder with HyperactivityCrebbp , Vegfa
Auriculocondylar Syndrome 3Edn1
Autism Spectrum DisorderAldoa
Autistic DisorderAdm , Cp , Lep , Nos2 , Serpine1 , Tf
AzoospermiaEpas1
Barrett EsophagusMcl1
Behcet SyndromeAbcb1a , Edn1 , Hmox1 , Itgb2 , Serpine1 , Vegfa
BerylliosisHmox1
Beta-ThalassemiaEpo , Tert , Tfrc
Bile Duct DiseasesFech
Bipolar DisorderAkt1 , Bhlhe40
Blast CrisisHmox1
BlindnessVegfa
Blood Coagulation DisordersHmox1
Body Weight ChangesLep
BrachydactylySmad4
BradycardiaEdn1
Brain DeathHmox1
Brain DiseasesCp
Brain EdemaCp , Hmox1 , Nos2 , Vegfa
Brain InfarctionAdm
Brain InjuriesAkt1 , Apex1 , Elk1 , Epas1 , Epo , Fos , Hmox1 , Jun , Kdr , Lep , Nos2 , Nt5e , Tf , Vegfa
Brain IschemiaAkt1 , Apex1 , Cited2 , Cp , Creb1 , Cxcl12 , Edn1 , Hif1a , Hmox1 , Jun , Kdr , Mmp14 , Nos2 , Serpine1 , Slc11a2
Brain NeoplasmsVegfa
Breast AdenocarcinomaAkt1
Breast NeoplasmsAbcb1a , Abcg2 , Adm , Akt1 , Aldoa , Apex1 , Car9 , Cxcl12 , Cxcr4 , Efna1 , Eng , Eno1 , Ep300 , Epo , Flt1 , Fos , Hif1a , Hmox1 , Igfbp1 , Jun , Kdr , Lep , Mmp14 , Ncoa1 , Ncoa2 , Ndrg1 , Nos2 , Serpine1 , Slc2a1 , Smad4 , Tert , Tfrc , Vegfa
Bronchial DiseasesNos2
Bronchial HyperreactivityNos2
Bronchiolitis ObliteransAdora2a , Edn1 , Hmox1 , Nos2
Bronchiolitis, ViralNos2
Bronchitis, ChronicEdn1 , Nos2 , Vegfa
Bronchopulmonary DysplasiaEdn1 , Epas1 , Flt1 , Hif1a
BurnsHif1a , Igfbp1 , Nos2
Calcification of Joints and ArteriesNt5e
CalcinosisEpo , Itgb2
Carbon Monoxide PoisoningHmox1
Carbon Tetrachloride PoisoningHmox1
CarcinomaAbcb1a , Eno1 , Furin , Hif1a , Pkm , Tf , Vhl
Carcinoma in SituAkt1 , Pou5f1
Carcinoma, Adenoid CysticCrebbp , Ep300
Carcinoma, Basal CellTert
Carcinoma, DuctalCar9 , Hif1a , Slc2a1
Carcinoma, Ductal, BreastAbcb1a , Hif1a , Smad4
Carcinoma, EmbryonalPou5f1
Carcinoma, EndometrioidAkt1 , Car9 , Kdr
Carcinoma, HepatocellularAbcb1a , Akt1 , Apex1 , Cops5 , Cp , Crebbp , Cxcl12 , Eng , Eno1 , Ep300 , Fos , Hif1a , Hnf4a , Jun , Pgk1 , Pkm , Slc2a1 , Smad4 , Tert , Tfrc
Carcinoma, Intraductal, NoninfiltratingBnip3 , Car9 , Flt1 , Hif1a , Slc2a1 , Tert , Vegfa
Carcinoma, Non-Small-Cell LungAbcb1a , Akt1 , Eno1 , Epas1 , Hif1a , Lep , Ndrg1 , Tert , Vegfa
Carcinoma, Pancreatic DuctalNdrg1 , Nos2 , Vegfa , Vhl
Carcinoma, Renal CellAbcb1a , Abcg2 , Akt1 , Car9 , Eloc , Epas1 , Flt1 , Hif1a , Jun , Kdr , Lep , Ndrg1 , Pgk1 , Slc2a1 , Smad4 , Tert , Tfrc , Vegfa , Vhl
Carcinoma, Squamous CellAkt1 , Crebbp , Eno1 , Ep300 , Kdr , Rack1 , Vegfa
Carcinoma, Squamous Cell of Head and NeckAbcb1a , Abcg2 , Akt1 , Crebbp , Ep300 , Ndrg1 , Serpine1 , Smad4
Carcinoma, Transitional CellAkt1 , Car9 , Crebbp , Ep300 , Kdr , Mmp14 , Pou5f1 , Smad4 , Tert , Tfrc
Cardiac FibrosisEdn1 , Serpine1
CardiomegalyAkt1 , Edn1 , Ep300 , Epas1 , Hif1a , Hmox1
CardiomyopathiesAdora2a , Akt1 , Edn1 , Ep300 , Epo , Ldha , Vegfa
Cardiomyopathy, DilatedCreb1 , Edn1 , Egln1 , Mmp14
Cardiomyopathy, HypertrophicAdm , Edn1 , Npm1
Cardiovascular AbnormalitiesEdn1 , Gata2 , Nos2
Cardiovascular DiseasesEdn1
Carotid Artery DiseasesHmox1
Carotid Artery InjuriesSerpine1 , Sp1
Carotid Artery ThrombosisHmox1
Carotid StenosisMmp14
Cartilage DiseasesEdn1 , Gata2
CataractSlc2a1
Celiac DiseaseEts1 , Tfrc
Cell Transformation, NeoplasticCxcr4 , Edn1 , Epas1 , Fos , Jun , Mmp14 , Nos2 , Slc2a1 , Sp1 , Tfrc
Central Nervous System DiseasesEpo
Central Serous ChorioretinopathySerpine1
Cerebral HemorrhageApex1 , Cxcr4 , Flt1 , Hmox1 , Itgb2 , Kdr , Vegfa
Cerebral InfarctionHmox1 , Serpine1
Cerebrovascular DisordersEdn1
Cervical Intraepithelial NeoplasiaTert , Vegfa
Charcot-Marie-Tooth DiseaseNdrg1
Chlamydophila InfectionsMmp14
ChloracneItgb2
CholangiocarcinomaEpo , Nos2 , Smad4
Cholangitis, SclerosingHif1a , Nos2
CholestasisEng , Nos2 , Serpine1
CholesteatomaVegfa
Cholesteatoma, Middle EarHif1a , Vegfa
Choreoathetosis/Spasticity, EpisodicSlc2a1
Choroidal NeovascularizationFlt1 , Kdr , Lep , Vegfa
Choroidal Neovascularization, ExperimentalSerpine1
Chromosome AberrationsEpas1
Chronic Cerebral HypoperfusionHif1a , Tfrc
Chronic Intermittent HypoxiaBnip3 , Hk1 , Hk2
Chronic Lung Allograft DysfunctionEpas1
Chronic PeriodontitisCxcl12 , Cxcr4 , Itgb2
Chronic RhinitisEdn1
Chronobiology DisordersBhlhe40
CicatrixSmad4
Clear-Cell Metastatic Renal Cell CarcinomaEng , Ep300 , Vegfa
Cocaine-Related DisordersCreb1 , Fos
Cognition DisordersEpo , Smad4
ColitisHmox1 , Itgb2 , Kdr , Nos2 , Vegfa
Colitis, ExperimentalSmad4
Colitis, IschemicVegfa
Colitis, UlcerativeAbcb1a
Colonic NeoplasmsAkt1 , Cp , Ep300 , Flt1 , Hdac7 , Hif1a , Igfbp1 , Jun , Kdr , Lep , Nos2 , Slc2a1 , Tff3 , Vegfa
Colorectal NeoplasmsAbcb1a , Abcg2 , Akt1 , Arnt , Crebbp , Ep300 , Flt1 , Hk1 , Kdr , Pgm1 , Smad4 , Tfrc
Colorectal Neoplasms, Hereditary NonpolyposisSmad3 , Smad4
Congenital AtransferrinemiaTf
Congenital Disorders of GlycosylationPgm1
Congenital HyperinsulinismGck , Hnf4a
Constriction, PathologicHmox1
Corneal NeovascularizationFlt1 , Kdr , Vegfa
Coronary Artery DiseaseAkt1 , Cxcl12 , Edn1 , Eng , Epo , Gck , Hmox1 , Nos2 , Serpine1 , Tert , Vegfa
Coronary DiseaseFlt1 , Hmox1 , Kdr , Tert , Vegfa
Coronary RestenosisHmox1 , Itgb2
Coronary StenosisEdn1
Craniofacial AbnormalitiesEdn1 , Ep300 , Gata2 , Smad3 , Smad4
CraniosynostosesTwist1
Cri-du-Chat SyndromeTert
Crohn DiseaseAbcb1a , Kdr , Lep , Smad3 , Vegfa
Cryohydrocytosis, Stomatin-Deficient, with Mental Retardation, Seizures, Cataracts, and Massive HepatosplenomegalySlc2a1
CystadenomaAldoa
Cystic FibrosisEdn1 , Hmox1 , Lep , Nos2
CystitisKdr
Cystitis, InterstitialNos2
DeafnessSmad4
Deafness, Autosomal Dominant 51Fxn
Deficiency DiseasesCp
DementiaCp , Nos2
Dementia, VascularEpo , Flt1
Depressive DisorderAdora2a , Gata2 , Jun
DermatitisItgb2
Dermatitis HerpetiformisVegfa
Dermatitis, Allergic ContactFlt1 , Kdr , Sat1 , Vegfa
Dermatitis, ContactHmox1 , Kdr , Vegfa
Developmental DisabilitiesSlc2a1
Diabetes ComplicationsHif1a , Vegfa
Diabetes MellitusCp , Fxn , Gck , Hnf4a , Lep , Serpine1 , Slc2a1
Diabetes Mellitus, ExperimentalAbcb1a , Abcg2 , Adm , Adora2a , Akt1 , Cp , Cxcl12 , Edn1 , Ep300 , Epo , Ets1 , Flt1 , Furin , Gck , Hif1a , Hk1 , Hmox1 , Hnf4a , Kdr , Lep , Nos2 , Nt5e , Serpine1 , Slc2a1 , Tert , Tf , Vegfa
Diabetes Mellitus, Permanent NeonatalGck
Diabetes Mellitus, Type 1Cp , Cxcl12 , Edn1 , Ets1 , Nos2 , Tf
Diabetes Mellitus, Type 2Abcb1a , Adm , Akt1 , Arnt , Cp , Cxcl12 , Edn1 , Ep300 , Epas1 , Epo , Ets1 , Flt1 , Fxn , Gck , Hif1a , Hk1 , Hk2 , Hmox1 , Hnf4a , Kdr , Lep , Nos2 , Serpine1 , Slc2a1 , Smad4 , Vegfa
Diabetes, GestationalGck , Lep
Diabetic AngiopathiesCxcl12 , Hmox1 , Igfbp1 , Mmp14 , Nos2 , Serpine1 , Vegfa
Diabetic CardiomyopathiesHmox1 , Tert
Diabetic NephropathiesCreb1 , Edn1 , Eng , Ep300 , Epas1 , Epo , Flt1 , Hif1a , Hmox1 , Hnf4a , Igfbp1 , Kdr , Lep , Serpine1 , Slc2a1 , Tf , Vegfa
Diabetic NeuropathiesEpo , Nos2 , Vegfa
Diabetic RetinopathyAdm , Cxcl12 , Edn1 , Eng , Ep300 , Epo , Flt1 , Hif1a , Serpine1 , Vegfa
Dilatation, PathologicHmox1
Disease Models, AnimalAkt1 , Fos , Serpine1
Disease ProgressionAbcb1a , Apex1 , Flt1 , Tert
Disseminated Intravascular CoagulationSerpine1
Drug HypersensitivityAdora2a
Drug-Induced Liver InjuryAbcb1a , Arnt , Cp , Eng , Eno1 , Flt1 , Hmox1 , Tf
Drug-induced NeutropeniaAbcb1a
Drug-Related Side Effects and Adverse ReactionsAbcb1a , Abcg2 , Adora2a , Hmox1 , Igfbp1
Duodenal UlcerNos2 , Slc11a2 , Tfrc , Vegfa
DysgerminomaPou5f1
Dyskeratosis CongenitaTert
Dyskeratosis Congenita, Autosomal DominantTert
DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT, 2Tert
Dyskeratosis Congenita, Autosomal RecessiveTert
DyskinesiasCp
DyspneaEdn1
DystoniaSlc2a1
EchinococcosisTf
EdemaNos2
EmbolismMmp14
Embryo LossCxcl12
EmphysemaNos2
EncephalitisAbcb1a
Encephalomyelitis, Autoimmune, ExperimentalEpo , Flt1 , Kdr , Nos2 , Vegfa
Endometrial HyperplasiaCar9
Endometrial NeoplasmsApex1 , Ep300 , Flt1 , Jun , Kdr , Ncoa1 , Pgm1 , Smad3 , Smad4 , Tert , Vegfa
EndometriosisArnt , Fos , Igfbp1 , Kdr , Ncoa1 , Vegfa
EndotoxemiaAbcb1a , Aldoa , Edn1 , Ep300 , Epo , Hmox1 , Igfbp1 , Nos2 , Serpine1
EnterocolitisItgb2
Enterocolitis, NecrotizingAbcb1a , Bnip3 , Eno1 , Nos2
EosinophiliaAbcb1a
EpilepsyAbcb1a , Akt1 , Cp , Fos , Slc2a1
Epilepsy, AbsenceSlc2a1
Epilepsy, Familial Temporal Lobe, 3Abcb1a
Epilepsy, GeneralizedPgk1
Epilepsy, Idiopathic GeneralizedSlc2a1
Epilepsy, Temporal LobeAbcb1a , Kdr , Vegfa
EpistaxisEng
Erectile DysfunctionAkt1 , Edn1 , Kdr , Nos2 , Vegfa
Erythema MultiformeVegfa
Erythrocytosis, Familial, 1Egln1 , Epas1
Erythrocytosis, Familial, 2Vhl
Erythrocytosis, Familial, 3Egln1
Erythrocytosis, Familial, 4Epas1
Escherichia Coli InfectionsAbcb1a
Esophageal NeoplasmsAbcb1a , Eno1 , Ep300 , Hmox1 , Kdr , Mmp14 , Nos2 , Smad4
Esophageal Squamous Cell CarcinomaCrebbp , Ep300 , Hif1a
Esthesioneuroblastoma, OlfactoryHif1a
Exfoliation SyndromeEdn1
Familial Apoceruloplasmin DeficiencyCp
Familial Primary Pulmonary HypertensionEng , Smad4
Fanconi Renotubular Syndrome 4 with Maturity-Onset Diabetes of the YoungHnf4a
Fanconi SyndromeLdha
FatigueEpo
Fatty LiverCreb1 , Epas1 , Gck , Lep , Plin2 , Serpine1 , Tf
Fatty Liver, AlcoholicSerpine1
Femoral FracturesCxcl12 , Cxcr4 , Lep
Fetal DiseasesNos2
Fetal DistressEpo
Fetal Growth RetardationAbcb1a , Elk1 , Hnf4a , Lep , Nos2 , Slc2a1 , Tff3
Fetal MacrosomiaHnf4a
FeverHmox1
FibrosarcomaSerpine1 , Tert
FibrosisAkt1 , Car9 , Fech , Hmox1
Fibrous Dysplasia of BoneFos
Fractures, StressEng
Friedreich AtaxiaFxn
Friedreich Ataxia 1Fxn
Gallbladder NeoplasmsNos2
Gastrointestinal DiseasesEdn1 , Tf
Gastrointestinal NeoplasmsSmad4
GastroparesisHmox1
GastroschisisNos2
Genetic Diseases, InbornCrebbp , Egln1
Genetic Predisposition to DiseaseAbcb1a , Adora2a , Apex1
Gestational Trophoblastic DiseasePou5f1
GingivitisVegfa
GlaucomaCrebbp , Epo , Serpine1 , Vegfa
Glaucoma, Angle-ClosureEdn1
Glaucoma, NeovascularEdn1 , Vegfa
Glaucoma, Primary Open AngleEdn1
GlioblastomaAkt1 , Bhlhe40 , Crebbp , Hif1a , Ndrg1 , Vegfa
GliomaEpo , Kdr , Tert , Tfrc
GliosarcomaVegfa
GlomerulonephritisAdm , Ep300 , Fos , Itgb2 , Tf , Vegfa
Glomerulonephritis, IGAMmp14
Glomerulonephritis, MembranoproliferativeEdn1 , Ep300
Glomerulonephritis, MembranousTf
GlomerulosclerosisSerpine1 , Slc2a1
Glomerulosclerosis, Focal SegmentalEdn1 , Nos2 , Serpine1
Glomus Tympanicum TumorVegfa
Glucose IntoleranceLep
Glut1 Deficiency SyndromeSlc2a1
GLUT1 Deficiency Syndrome 2Slc2a1
Glycogen Storage Disease XIIAldoa
Glycogen Storage Disease XIVPgm1
Graft Occlusion, VascularHmox1
Graft vs Host DiseaseVegfa
Granulosa Cell TumorVegfa
Graves DiseaseSerpine1 , Vegfa
Graves OphthalmopathySerpine1
Growth DisordersHmox1
Growth Mental Deficiency Syndrome of MyhreSmad4
Hamartoma Syndrome, MultipleAkt1
Hand-Foot SyndromeKdr
Head and Neck NeoplasmsVegfa
Hearing Loss, Noise-InducedHif1a
Hearing Loss, SuddenSerpine1
Heart ArrestAkt1 , Ep300
Heart Defects, CongenitalAbcb1a , Cited2 , Edn1 , Hif1a , Pou5f1 , Vegfa
Heart DiseasesAbcb1a , Apex1 , Cp , Edn1 , Ep300 , Epo , Vegfa
Heart FailureAdm , Bnip3 , Edn1 , Eng , Epo , Fos , Hif1a , Hmox1 , Lep , Mmp14 , Nos2 , Serpine1 , Vegfa
Heart Septal DefectsCited2
Heart Septal Defects, VentricularEpo , Fos
Heart Valve DiseasesItgb2
Heat StrokeFos , Jun
Helicobacter InfectionsHmox1 , Tfrc
HemangioblastomaHif1a , Ndrg1
HEMANGIOBLASTOMA, CEREBELLARVhl
HemangiomaSlc2a1
Hemangioma, Capillary InfantileKdr , Slc2a1
Hemangioma, Cavernous, Central Nervous SystemFlt1 , Kdr
HemangiosarcomaFlt1 , Jun , Kdr , Vegfa
Hematologic DiseasesSerpine1
Hematologic NeoplasmsAbcb1a
Hematoma, Subdural, AcuteEpo
HematuriaFos
Heme Oxygenase 1 DeficiencyHmox1
HemochromatosisCp , Slc11a2
Hemoglobinuria, ParoxysmalCxcr4
HemolysisHmox1
Hemolytic Anemia, Nonspherocytic, due to Hexokinase DeficiencyHk1
Hemolytic-Uremic SyndromeEpo , Fos
Hemophilia AHmox1
HemorrhageBnip3 , Fos , Gata2 , Serpine1
HemosiderosisCp
Hemosiderosis, Systemic, due to AceruloplasminemiaCp
Hepatic EncephalopathyHif1a , Hmox1 , Nos2
Hepatic Veno-Occlusive DiseaseHmox1
HepatitisHmox1 , Nos2 , Tf
Hepatitis, AcuteNos2
Hepatitis, AnimalCp , Tff3
Hepatitis, AutoimmuneLep
Hepatitis, ChronicCp , Nos2
Hepatolenticular DegenerationCp
Hepatopulmonary SyndromeEdn1 , Hmox1
Hepatorenal SyndromeEdn1 , Hmox1
Hermanski-Pudlak SyndromeCp , Cxcr4
Hermansky-Pudlak Syndrome 3Cp
Hernia, DiaphragmaticEdn1
Hernias, Diaphragmatic, CongenitalEp300 , Vegfa
Heroin DependenceLep
Hirschsprung DiseaseSlc2a1
Hirschsprung Disease 1Crebbp , Kdr
HirsutismEp300
Histiocytoma, Angiomatoid FibrousCreb1
HIV InfectionsAbcb1a , Cxcl12
Hodgkin DiseaseJun
HoloprosencephalyCreb1
Hot FlashesHif1a
Hoyeraal Hreidarsson SyndromeTert
Huntington DiseaseCreb1 , Elk1 , Hdac7 , Lep
Hyaline Membrane DiseaseSerpine1
HydrophthalmosFlt1 , Kdr
HyperalgesiaAdm , Edn1 , Ep300 , Fos , Hif1a , Nos2
Hyperbilirubinemia, NeonatalHmox1
HypercapniaEdn1 , Lep
HypercholesterolemiaEdn1 , Eng , Lep , Vegfa
HyperemiaEgln1 , Nos2
HyperglycemiaEpas1 , Gck , Ldha , Sp1 , Tf
Hyperinsulinemic Hypoglycemia, Familial, 3Gck
HyperinsulinismAdm , Gck , Hmox1 , Hnf4a , Lep
HyperkinesisAdora2a , Fos
Hyperlipidemia, Familial CombinedHnf4a
HyperlipidemiasAbcb1a , Lep
HyperoxiaBnip3 , Edn1
Hyperoxic Lung InjuryHmox1
Hyperparathyroidism, SecondaryEng
HyperphagiaLep
HyperplasiaAkt1 , Hif1a , Hmox1 , Lep , Vegfa
HypersensitivityItgb2
HypertensionAdm , Adora2a , Akt1 , Edn1 , Egln1 , Eng , Eno1 , Ep300 , Epo , Fos , Gck , Hif1a , Hmox1 , Jun , Kdr , Lep , Nos2 , Serpine1 , Slc2a1 , Tf , Vegfa , Vhl
Hypertension, EssentialNos2
Hypertension, MalignantAdm
Hypertension, PortalAdm , Edn1 , Hmox1 , Vegfa
Hypertension, Pregnancy-InducedEdn1 , Hmox1
Hypertension, PulmonaryAdm , Car9 , Edn1 , Eng , Epas1 , Epo , Hif1a , Hif3a , Hk1 , Hmox1 , Nos2 , Serpine1 , Smad4 , Tert
Hypertension, RenalHmox1 , Nos2
Hypertension, RenovascularAdm
HyperthyroidismCp , Hmox1 , Serpine1
HypertriglyceridemiaHnf4a , Lep , Plin2
HypertrophyEdn1
Hypertrophy, Left VentricularEdn1
Hypertrophy, Right VentricularAkt1 , Car9 , Eng , Hmox1
Hypoglossal Nerve InjuriesSmad3 , Smad4
HypoglycemiaCreb1 , Epo , Gck , Hnf4a
HypogonadismEdn1 , Lep
HypotensionAdora2a , Edn1
Hypotension, OrthostaticAbcb1a
HypothermiaNos2
HypothyroidismNcoa1 , Nos2 , Slc2a1
HypoventilationLep
Hypoxia, BrainEp300 , Epo
Hypoxia-Ischemia, BrainEpo , Hif1a , Hmox1 , Kdr , Nos2 , Serpine1 , Tert , Tf , Vegfa
Idiopathic Pulmonary FibrosisTert
IleusHmox1
Immunodeficiency 21Gata2
Immunodeficiency 46Tfrc
Immunologic Deficiency SyndromesTfrc
InfarctionEpas1 , Hif1a
Infarction, Middle Cerebral ArteryBnip3 , Edn1 , Eng , Epo , Fos , Hif1a , Hmox1 , Nos2 , Serpine1 , Slc2a1
Infertility, FemaleLep
Infertility, MaleEno1
InflammationAbcb1a , Akt1 , Edn1 , Epo , Hmox1 , Lep , Nos2 , Tf , Tfrc , Vegfa
Inflammatory Bowel Disease 11Cxcr4 , Hnf4a , Kdr , Vegfa
Inflammatory Bowel Disease 13Abcb1a
Inflammatory Bowel DiseasesCul2 , Nos2 , Vegfa
Influenza, HumanNos2
Insulin ResistanceFxn , Gck , Hmox1 , Lep , Nos2 , Plin2 , Serpine1 , Tf
InsulinomaAdm , Cxcl12
Intellectual DisabilityEp300 , Slc2a1
Intermittent ClaudicationEpas1
Intervertebral Disc DiseaseHif1a
Intervertebral Disc DisplacementAkt1
Intestinal DiseasesNos2
Intestinal IschemiaAdm
Intestinal PolyposisAbcb1a , Eng , Smad4
Intestinal PolypsJun
Intestinal Reperfusion InjuryHmox1 , Serpine1
Intracranial AneurysmMmp14
Intracranial Arteriovenous MalformationsEng , Flt1 , Kdr , Vegfa
Intracranial HemorrhagesTf
Invasive Pulmonary AspergillosisVegfa
Iron Metabolism DisordersCp , Hmox1 , Tfrc
Iron OverloadCp , Epas1 , Slc11a2 , Tf
IschemiaCp , Cxcl12 , Flt1 , Hmox1 , Mmp14
Ischemic Attack, TransientBnip3 , Creb1 , Cxcl12 , Elk1 , Ep300 , Epo , Flt1 , Hif1a , Rack1 , Serpine1 , Tert
JaundiceFech
Jaundice, ObstructiveAdm
Juvenile Polyposis SyndromeSmad4
Juvenile Polyposis with Hereditary Hemorrhagic TelangiectasiaSmad4
Keratitis, HerpeticKdr
Keratosis Follicularis Spinulosa Decalvans, X-LinkedSat1
Kidney DiseasesAbcb1a , Edn1 , Epo , Nos2 , Tert , Tff3
Kidney Diseases, CysticVhl
Kidney Failure, ChronicAbcb1a , Bnip3 , Edn1 , Epo , Hmox1 , Lep , Serpine1
Kidney NeoplasmsAbcb1a , Akt1 , Flt1 , Itgb2 , Jun , Kdr , Ndrg1 , Vhl
Kidney Reperfusion InjuryAdm , Bnip3 , Egln1 , Egln3 , Eng , Ep300 , Epo , Fos , Hif1a , Hmox1 , Itgb2 , Lep
Lactate Dehydrogenase Deficiency Type ALdha
Laryngotracheal Stenosis, Progressive, with Short Stature and ArthropathySmad4
LathyrismKdr
Lead Poisoning, Nervous SystemEp300
Learning DisordersHmox1 , Vegfa
LeiomyomaSmad3
LeiomyosarcomaFlt1 , Tert
LeishmaniasisMcl1
Leishmaniasis, VisceralHmox1
LEPTIN DEFICIENCY OR DYSFUNCTIONLep
Leukemia, Lymphocytic, Chronic, B-CellAbcg2 , Tert , Tfrc
Leukemia, LymphoidEng , Tert
Leukemia, Megakaryoblastic, AcuteAbcg2
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveAbcb1a , Abcg2 , Car9 , Hmox1 , Npm1 , Tert , Vegfa
Leukemia, MyeloidGata2 , Vegfa
Leukemia, Myeloid, AcuteAbcg2 , Crebbp , Cxcr4 , Gata2 , Hmox1 , Id2 , Ncoa2 , Npm1 , Tert
Leukemia, Myelomonocytic, JuvenileGata2
Leukemia, Plasma CellTert
Leukemia, Promyelocytic, AcuteAkt1 , Itgb2 , Npm1
Leukocyte Adhesion Deficiency Type 1Itgb2
Leukocyte DisordersItgb2
Leukocyte-Adhesion Deficiency SyndromeItgb2
LeukopeniaCxcr4
Lewy Body DiseaseEdn1 , Elk1 , Nos2
Leydig Cell TumorFlt1
Limb IschemiaEpo , Hif1a , Hmox1 , Vegfa
Liver CirrhosisArnt , Cp , Edn1 , Flt1 , Hnf4a , Igfbp1 , Smad3 , Vegfa
Liver Cirrhosis, AlcoholicSmad3
Liver Cirrhosis, BiliaryAbcg2 , Hif1a , Hmox1 , Igfbp1 , Lep , Nos2
Liver Cirrhosis, ExperimentalAbcb1a , Adm , Adora2a , Cxcl12 , Edn1 , Fos , Gck , Hmox1 , Id2 , Igfbp1 , Itgb2 , Lep , Ndrg1 , Nos2 , Nt5e , Plin2 , Smad4 , Tert , Tf , Vegfa
Liver DiseasesHmox1 , Nos2
Liver Diseases, AlcoholicHif1a
Liver Diseases, ParasiticSmad4
Liver FailureVegfa
Liver Failure, AcuteNos2
Liver InjuryAbcg2 , Gck , Npm1
Liver NeoplasmsAkt1 , Crebbp , Hmox1 , Jun , Ndrg1 , Serpine1 , Slc11a2 , Slc2a1 , Tert
Liver Neoplasms, ExperimentalCp , Kdr , Nos2
Liver Reperfusion InjuryAdm , Hmox1 , Serpine1 , Tert
Loeys-Dietz SyndromeSmad3
Loeys-Dietz Syndrome 3Smad3
Low Tension GlaucomaEdn1
Lung DiseasesAdora2a , Apex1 , Hif1a , Hmox1 , Lep , Nos2 , Serpine1 , Vegfa
Lung Diseases, FungalGata2 , Nos2
Lung Diseases, InterstitialHmox1 , Nos2 , Serpine1
Lung InjuryHmox1 , Slc11a2
Lung NeoplasmsAkt1 , Fos , Hmox1 , Jun , Mcl1 , Nos2 , Tert , Tfrc , Vhl
Lung Reperfusion InjuryHmox1 , Serpine1
Lupus Erythematosus, SystemicEts1 , Nos2 , Tert
LymphangiomaKdr
Lymphatic MetastasisCar9 , Kdr , Pou5f1 , Smad4 , Vegfa
LymphedemaGata2
Lymphedema, Primary, with MyelodysplasiaGata2
Lymphoma, AIDS-RelatedTfrc
Lymphoma, B-CellAbcg2
Lymphoma, Extranodal NK-T-CellAbcb1a
Lymphoma, FollicularCrebbp
Lymphoma, Large B-Cell, DiffuseAbcb1a , Abcg2
Lymphoma, Large-Cell, AnaplasticNpm1 , Twist1
Lymphoma, Non-HodgkinTfrc
Lymphoma, T-CellAkt1 , Ep300
Lymphoma, T-Cell, CutaneousMcl1
Macular DegenerationFlt1 , Kdr , Serpine1 , Vegfa
Macular EdemaEpo , Flt1 , Kdr , Vegfa
MalariaNos2
Mammary Neoplasms, AnimalEno1 , Furin , Kdr , Pkm , Tf
Mammary Neoplasms, ExperimentalAbcb1a , Abcg2 , Akt1 , Car9 , Eno1 , Epo , Furin , Hif1a , Hmox1 , Kdr , Lep , Ncoa1 , Pkm , Tf , Vegfa
Mandibular FracturesCited2
Manganese PoisoningBnip3 , Nos2
Marfan SyndromeMmp14 , Nos2
Marijuana AbuseAbcb1a , Akt1
Mastocytosis, SystemicHmox1
Maturity-Onset Diabetes of the YoungGck , Hnf4a
Maturity-Onset Diabetes of the Young, Type 1Hnf4a
Maturity-Onset Diabetes of the Young, Type 2Gck
MedulloblastomaCrebbp , Ep300
MelanomaAkt1 , Apex1 , Arnt , Cp , Crebbp , Eng , Ep300 , Epo , Flt1 , Kdr , Ndrg1 , Tert , Vegfa
Melanoma, Cutaneous MalignantHif1a
Melanoma, Cutaneous Malignant, Susceptibility To, 9Tert
Melanoma, ExperimentalTert
Memory DisordersCreb1 , Hif1a , Vegfa
Meningeal NeoplasmsAkt1
MeningiomaAkt1
MeningomyeloceleSlc2a1
Menkes Kinky Hair SyndromeCp
Mental DisordersAbcb1a
Mercury Poisoning, Nervous SystemJun
Mesothelioma, MalignantCxcl12 , Slc2a1 , Tf
Metabolic AcidosisEdn1
Metabolic Syndrome XHmox1 , Hnf4a , Lep , Serpine1 , Tf , Vegfa
Metabolism, Inborn ErrorsSlc2a1
MetaplasiaCar9 , Tff3
MicrocephalyEp300 , Slc2a1
MicrognathismEp300
Micronuclei, Chromosome-DefectiveApex1 , Hif1a
Microphthalmia, Cataracts, and Iris AbnormalitiesSmad4
Microvascular Complications of Diabetes, Susceptibility To, 1Epo , Vegfa
Microvascular Complications of Diabetes, Susceptibility To, 2Epo , Vegfa
Microvascular Complications of Diabetes, Susceptibility To, 3Epo
Microvascular Complications of Diabetes, Susceptibility To, 7Epo , Vegfa
Mitochondrial DiseasesNos2
Mood DisordersAkt1
Morphine DependenceCreb1
Mouth NeoplasmsEno1 , Ets1 , Ndrg1 , Rack1
Movement DisordersAdora2a
Mucocutaneous Lymph Node SyndromeFlt1 , Hmox1 , Vegfa
MucositisNos2 , Tff3
Multiple MyelomaAbcg2 , Bnip3 , Eng , Hk1 , Mcl1 , Tert , Tfrc , Vegfa
Multiple Organ FailureSerpine1
Multiple SclerosisEdn1 , Vegfa
Multiple TraumaSerpine1
Muscle HypotoniaEp300
Muscle WeaknessSlc2a1
Muscular AtrophyAkt1 , Cited2 , Serpine1 , Tfrc
Muscular DiseasesSmad4
Musculoskeletal AbnormalitiesEpas1
Mycoplasma InfectionsNos2
Mycosis FungoidesHif1a
Myelodysplastic SyndromesEpo , Gata2 , Npm1 , Tert
Myeloproliferative DisordersNpm1
Myocardial InfarctionAkt1 , Bnip3 , Creb1 , Cxcl12 , Edn1 , Egln1 , Egln3 , Epas1 , Epo , Flt1 , Hif1a , Hmox1 , Kdr , Ldha , Mmp14 , Nos2 , Npm1 , Serpine1 , Smad4 , Vegfa
Myocardial IschemiaAdm , Aldoa , Bhlhe40 , Edn1 , Hif1a , Hk1 , Hk2 , Hmox1 , Kdr , Pfkfb3 , Pgm1 , Tfrc , Vegfa
Myocardial Reperfusion InjuryAkt1 , Apex1 , Bnip3 , Edn1 , Egln1 , Hif1a , Hmox1 , Lep , Nos2 , Serpine1 , Slc2a1 , Smad3 , Smad4 , Tfrc , Vegfa
Myocardial StunningNos2
MyoglobinuriaLdha
MyopiaEp300
Nasal PolypsAbcb1a , Jun , Kdr , Nos2 , Vegfa
NauseaAbcb1a
NecrosisEpo , Nos2
NeointimaFlt1 , Hmox1 , Serpine1
Neoplasm InvasivenessAldoa , Cxcl12 , Cxcr4 , Eno1 , Epo , Hif1a , Hmox1 , Mmp14 , Pkm , Sp1 , Tf , Twist1
Neoplasm MetastasisAbcb1a , Aldoa , Cxcl12 , Cxcr4 , Edn1 , Epo , Flt1 , Kdr , Ncoa1 , Ndrg1 , Nos2 , Sp1 , Twist1 , Vegfa
Neoplasm Recurrence, LocalVegfa
NeoplasmsAbcb1a , Cited2 , Tert , Vegfa , Vhl
Neoplasms, ExperimentalArnt , Ldha , Vegfa
Neoplasms, Germ Cell and EmbryonalAbcb1a , Pou5f1
Neoplastic Syndromes, HereditarySmad4 , Vhl
Neovascularization, PathologicKdr , Serpine1 , Vegfa
NephritisEdn1 , Itgb2
Nephropathy, Chronic TubulointerstitialEdn1 , Hmox1
NephrosisEdn1 , Itgb2
Nephrotic SyndromeEpo , Serpine1 , Tf
Nerve DegenerationCp , Epo , Lep , Tf , Vegfa
Nervous System DiseasesAbcb1a , Abcg2 , Fos , Serpine1 , Slc2a1
Neural Tube DefectsCited2 , Npm1
NeuralgiaCxcr4 , Kdr
NeurilemmomaKdr
Neuritis, Autoimmune, ExperimentalEpas1 , Epo , Hif1a , Nos2
NeuroblastomaAbcb1a , Tert
Neurodegenerative DiseasesEpo , Hmox1
Neurofibromatosis 1Vegfa
Neurofibromatosis 2Vegfa
NeurofibrosarcomaKdr , Vegfa
Neuroma, AcousticVegfa
Neuropathy, Hereditary Motor and Sensory, LOM TypeNdrg1
Neuropathy, Hereditary Motor and Sensory, Russe TypeHk1
Neuropathy, PainfulEp300
Neurotoxicity SyndromesAbcb1a , Abcg2 , Fos
NeutropeniaAbcb1a
Neutropenia, Nonimmune Chronic Idiopathic, AdultTert
Non-alcoholic Fatty Liver DiseaseAbcb1a , Lep , Nos2 , Tfrc
Nonproliferative Diabetic RetinopathyFlt1
Nutrition DisordersTfrc
ObesityAdm , Akt1 , Bnip3 , Edn1 , Ep300 , Fxn , Gck , Hk1 , Hk2 , Hmox1 , Lep , Nos2 , Pfkfb3 , Sat1 , Serpine1 , Slc2a1 , Tf , Tfrc
Obesity, MorbidHif1a , Lep
Odontogenic CystsSmad4
Optic Nerve DiseasesEdn1
Optic Nerve InjuriesEdn1 , Ep300 , Jun
Oral Squamous Cell CarcinomaSerpine1
Oral UlcerEdn1 , Lep
Oropharyngeal NeoplasmsNdrg1
Ossification, HeterotopicSmad4
OsteoarthritisEno1 , Epas1 , Flt1 , Hif1a , Lep , Slc2a1 , Smad3
Osteoarthritis, ExperimentalFlt1
Osteoarthritis, KneeEpas1 , Epo , Lep
OsteochondrodysplasiasFlt1 , Kdr , Vegfa
OsteopetrosisJun
OsteoporosisEno1 , Lep , Pkm
Osteoporosis, PostmenopausalHif1a
OsteosarcomaAkt1 , Cited2 , Jun , Vegfa
Otitis MediaNos2 , Vegfa
Otitis Media with EffusionFlt1 , Kdr , Vegfa
Ovarian NeoplasmsAbcb1a , Abcg2 , Akt1 , Apex1 , Edn1 , Flt1 , Hif1a , Kdr , Slc2a1 , Smad4 , Tert , Tfrc , Vegfa
Oxygen-Induced RetinopathyHif1a , Kdr , Serpine1 , Vegfa
PainAdm , Akt1 , Cxcl12 , Edn1
Pain, PostoperativeAbcb1a
Pancreatic AdenocarcinomaCxcr4 , Smad4
Pancreatic CarcinomaSmad4
Pancreatic CystVhl
Pancreatic DiseasesHmox1
Pancreatic NeoplasmsAdm , Hif1a , Kdr , Nos2 , Smad3 , Smad4 , Tert , Vhl
PancreatitisItgb2
Pancreatitis, Acute NecrotizingNos2 , Serpine1
PancytopeniaEpas1 , Epo
Panic DisorderAdora2a
Papilloma, InvertedKdr , Vegfa
Paraneoplastic SyndromesEpo
ParaparesisHmox1
ParaplegiaAkt1 , Nos2
ParatuberculosisTf
Parkinson DiseaseAbcb1a , Akt1 , Cp , Edn1 , Epo , Hmox1 , Lep , Nos2 , Slc11a2
Parkinson Disease, SecondaryAbcb1a , Nos2
Parkinsonian DisordersHmox1 , Slc11a2 , Vhl
Pasteurellaceae InfectionsCp
Pemphigoid, BullousVegfa
Peptic UlcerEdn1 , Hmox1
Periodontal AtrophyVegfa
PeriodontitisCxcl12
Peripheral Arterial DiseaseSerpine1
Peripheral Nervous System DiseasesAbcb1a , Jun
Peripheral Vascular DiseasesAdm
Peritoneal AdhesionsSerpine1
Peritoneal NeoplasmsSlc2a1
PheochromocytomaVhl
Phosphoglycerate Kinase 1 DeficiencyPgk1
Phyllodes TumorHif1a , Tfrc
Pick Disease of the BrainCreb1 , Fos
Placental InsufficiencyEpo
Plaque, AtheroscleroticSp1
Plasminogen Activator Inhibitor-1 DeficiencySerpine1
Pleomorphic Xanthoastrocytoma Abcb1a , Epo , Gck , Igfbp1 , Lep , Serpine1 , Twist1
PleurisyNos2
PneumoniaAdora2a , Edn1 , Hmox1 , Itgb2 , Serpine1 , Slc11a2
Pneumonia, AspirationEdn1 , Nos2
Pneumonia, BacterialLep , Serpine1
Pneumonia, PneumococcalHmox1 , Lep , Nos2
Pneumonia, PneumocystisNos2
Pneumonia, ViralHmox1
PneumoperitoneumEdn1
PneumothoraxHmox1
PoisoningAbcb1a , Epo
Polyarteritis NodosaVegfa
Polycystic Kidney DiseasesEpas1 , Hif1a
Polycystic Kidney, Autosomal DominantEdn1 , Fos
Polycystic Kidney, Autosomal RecessiveAkt1
Polycystic Ovary SyndromeLep , Tfrc , Vegfa
PolycythemiaEgln1 , Epas1 , Serpine1 , Vhl
PolydipsiaLep
PolyneuropathiesEpo , Serpine1
Polypoidal Choroidal VasculopathyVegfa
PolyuriaLep
Porphyria, ErythropoieticFech
PorphyriasEpo
Porphyrias, HepaticFech
Pre-EclampsiaCp , Edn1 , Eng , Epas1 , Flt1 , Hmox1 , Lep , Serpine1 , Vegfa
Precancerous ConditionsAkt1 , Igfbp1 , Smad3 , Smad4 , Tff3 , Vegfa
Precursor Cell Lymphoblastic Leukemia-LymphomaAbcb1a , Abcg2 , Arnt , Crebbp , Eng , Hk1 , Tert
Precursor T-Cell Lymphoblastic Leukemia-LymphomaAbcg2 , Cxcr4
Pregnancy ComplicationsEpo , Ncoa2
Pregnancy in DiabeticsEng , Vegfa
Premature BirthEdn1
PresbycusisEdn1
Pressure UlcerHif1a , Kdr , Vegfa
Proliferative Diabetic RetinopathyFlt1 , Serpine1
Prostatic Intraepithelial NeoplasiaApex1 , Flt1 , Smad4
Prostatic NeoplasmsAkt1 , Apex1 , Bnip3 , Crebbp , Cxcl12 , Eng , Ep300 , Flt1 , Hif1a , Hmox1 , Jun , Kdr , Lep , Ncoa1 , Ncoa2 , Ndrg1 , Serpine1 , Smad3 , Smad4 , Tert , Tf , Tff3 , Tfrc , Vegfa
ProstatitisSmad4
Protein C Deficiency, AcquiredSerpine1
ProteinuriaLep , Vegfa
Proteus SyndromeAkt1
Protoporphyria, ErythropoieticFech
Pseudoxanthoma ElasticumVegfa
PsoriasisCp , Epas1 , Flt1 , Hif1a , Itgb2 , Kdr , Nos2 , Vegfa
Psychoses, Substance-InducedAdora2a , Akt1
PterygiumKdr , Vegfa
Pulmonary Arterial Hypertension, Hereditary Hemorrhagic Telangiectasia-RelatedEng
Pulmonary Disease, Chronic ObstructiveAdora2a , Bnip3 , Edn1 , Flt1 , Hmox1 , Kdr , Lep , Mmp14 , Nos2 , Serpine1 , Smad4 , Vegfa
Pulmonary EdemaAdora2a , Nos2 , Vegfa
Pulmonary Edema of MountaineersHmox1
Pulmonary EmbolismEdn1 , Epo
Pulmonary EmphysemaHmox1 , Nos2
Pulmonary EosinophiliaEpas1 , Nos2
Pulmonary FibrosisEdn1 , Hmox1 , Nos2 , Serpine1 , Smad4 , Twist1
Pulmonary Fibrosis and/or Bone Marrow Failure, Telomere-Related, 1Tert
Pulmonary Hypertension, Hypoxia-Induced Egln1 , Egln3
Purpura, Schoenlein-HenochHmox1
Question Mark Ears, IsolatedEdn1
Radiation InjuriesHif1a
Radiation Injuries, ExperimentalEng , Hif1a , Hmox1
RecurrenceCxcl12 , Flt1
Renal FibrosisEng , Epas1 , Serpine1
Renal InsufficiencyEdn1 , Epo , Hif1a
Renal Insufficiency, ChronicTert
Renal Vascular DiseasesEdn1
Reperfusion InjuryAbcb1a , Abcg2 , Adm , Adora2a , Akt1 , Aldoa , Apex1 , Cxcl12 , Edn1 , Ep300 , Ets1 , Fos , Hif1a , Hmox1 , Jun , Kdr , Lep , Nos2 , Slc2a1 , Tert
Respiratory Distress Syndrome, AdultEdn1 , Hmox1 , Lep , Serpine1
Respiratory Distress Syndrome, NewbornHmox1
Respiratory HypersensitivityNos2 , Serpine1
Restless Legs SyndromeSlc11a2 , Tf
Retina Reperfusion InjuryHmox1 , Vegfa
Retinal DegenerationCp , Edn1 , Epo
Retinal DetachmentBnip3 , Edn1 , Epo
Retinal DiseasesEpas1 , Hmox1 , Nos2 , Vegfa
Retinal IschemiaHmox1
Retinal NeovascularizationHif1a , Vegfa
Retinal TelangiectasisKdr , Vegfa
Retinal Vein OcclusionSerpine1 , Vegfa
Retinitis PigmentosaEdn1 , Vegfa
RETINITIS PIGMENTOSA 79Hk1
Retinopathy of PrematurityEpo , Flt1 , Kdr , Nos2 , Serpine1 , Vegfa
RhabdomyolysisHmox1
RhabdomyosarcomaVegfa
RhinitisLep , Nos2 , Serpine1 , Vegfa
Rhinitis, AllergicAbcb1a , Serpine1
Rhinitis, Allergic, PerennialHmox1 , Nos2
Rhinitis, Allergic, SeasonalKdr , Vegfa
RhinosinusitisSerpine1
Robinow Sorauf SyndromeTwist1
Rubinstein-Taybi SyndromeCrebbp , Ep300
Saethre-Chotzen Syndrome with Eyelid AnomaliesTwist1
Sarcoidosis, PulmonaryHmox1 , Nos2
SarcomaKdr , Mcl1
Sarcoma, ExperimentalEpo
Schistosomiasis MansoniNos2
SchizophreniaAdora2a , Akt1 , Aldoa , Cp , Creb1 , Elk1 , Kdr , Tfrc
Sciatic NeuropathyCreb1 , Hmox1 , Serpine1
Scleroderma, DiffuseKdr
Scleroderma, LimitedKdr
Scleroderma, SystemicEdn1 , Kdr , Vegfa
ScoliosisCrebbp
SeizuresAbcb1a , Adora2a , Apex1 , Epo , Fos , Lep , Nos2 , Slc2a1
SeminomaPou5f1 , Smad4 , Vegfa
SepsisAdm , Edn1 , Ep300 , Flt1 , Lep , Nos2 , Serpine1
Severe Combined ImmunodeficiencyEpo , Tfrc
Sezary SyndromeCrebbp
Shock, CardiogenicEpo
Shock, HemorrhagicAdm , Epo , Hmox1 , Nos2
Shock, SepticAdm , Hmox1 , Nos2 , Serpine1
Short Bowel SyndromeLep
SilicosisHmox1 , Nos2
Sjogren's SyndromeHmox1
Skin DiseasesId2 , Pfkfb3
Skin NeoplasmsAkt1 , Flt1 , Hif1a , Sp1 , Vegfa
Skin UlcerItgb2
Sleep Apnea SyndromesSerpine1
Sleep Apnea, ObstructiveAbcb1a , Edn1 , Hmox1 , Lep , Nos2 , Serpine1
Sleep Disorders, Circadian RhythmBhlhe40
Sleep Initiation and Maintenance DisordersAdora2a
Sleep Wake DisordersBhlhe41
Slow Coronary FlowEdn1
Small Cell Lung CarcinomaAkt1 , Crebbp , Ep300 , Id2 , Ndrg1
Small-For-Size SyndromeVegfa
Smith-Magenis SyndromeNos2
Smooth Muscle TumorNdrg1
Spinal Cord CompressionEpo
Spinal Cord InjuriesAdora2a , Akt1 , Apex1 , Bnip3 , Epo , Flt1 , Hif1a , Hmox1 , Id2 , Jun , Kdr , Lep , Nos2 , Tert , Vegfa , Vhl
Spinal Cord Reperfusion InjuryCxcl12 , Cxcr4
Spinal DysraphismApex1
Spinocerebellar Ataxia 17Hmox1
Spondylocostal Dysostosis 5Aldoa
Squamous Cell Carcinoma of the LungAkt1 , Crebbp , Ep300
Squamous Cell Carcinoma of the TongueKdr
StarvationAdm
Status EpilepticusAbcb1a , Abcg2 , Apex1 , Cxcl12 , Epo , Fos , Hmox1 , Jun , Nos2 , Nt5e , Vegfa
Stevens-Johnson SyndromeCops5 , Ep300 , Nos2 , Rbx1
Still's Disease, Adult-OnsetVegfa
Stomach NeoplasmsApex1 , Bnip3 , Eno1 , Hmox1 , Jun , Npm1 , Nt5e , Plin2 , Serpine1 , Smad4 , Twist1
Stomach UlcerAdm , Epo , Lep , Nos2 , Vegfa
StrokeAdm , Akt1 , Edn1 , Hmox1 , Kdr , Nos2 , Serpine1 , Vegfa
Subarachnoid HemorrhageBnip3 , Edn1 , Epo , Hif1a , Hmox1 , Nos2
Substance Withdrawal SyndromeAdora2a , Creb1 , Fos , Nos2
Sudden Infant DeathVegfa
Systemic Inflammatory Response SyndromeNos2
TachycardiaLep
Tachycardia, VentricularEpo
Takayasu ArteritisNos2
Telangiectasia, Hereditary HemorrhagicEng , Smad4
Telangiectasia, Hereditary Hemorrhagic, Type 1Eng
Temporomandibular Joint DisordersHif1a
Tendon InjuriesFos
TeratomaPgm1 , Tert
Testis Reperfusion InjuryHif1a , Hmox1
ThrombocytopeniaEpo
ThrombosisEpo , Hmox1 , Serpine1
Thrombotic MicroangiopathiesNos2 , Vegfa
Thumb DeformityCrebbp
Thyroid DiseasesId2
Thyroid NeoplasmsCp , Epo , Hif1a , Tert
Tobacco Addiction, Susceptibility ToEgln2
Tongue NeoplasmsFos , Vegfa
Translocation, GeneticAbcb1a
Transplant RejectionKdr
TremorAdora2a
Trigeminal NeuralgiaFos
Trypanosomiasis, AfricanNos2
Tuberculosis, PulmonaryJun , Nos2
Tubulointerstitial FibrosisEpo
Tumor Predisposition SyndromeSmad4 , Vhl
Turner SyndromeNos2
Tympanic Membrane PerforationVegfa
UlcerHif1a , Mmp14
UremiaEdn1 , Epo , Flt1 , Kdr , Nos2
Ureteral ObstructionAdm , Akt1 , Edn1 , Nos2 , Serpine1
URIC ACID CONCENTRATION, SERUM, QUANTITATIVE TRAIT LOCUS 1Abcg2
Urinary Bladder Neck ObstructionHif1a
Urinary Bladder NeoplasmsAkt1 , Apex1 , Car9 , Crebbp , Ep300 , Hk1 , Kdr , Serpine1 , Smad4 , Tert , Tfrc , Vhl
Urinary Bladder, OveractiveEdn1
Urinary RetentionEdn1
Urinary Tract InfectionsNos2
Urologic NeoplasmsHif1a , Vegfa
Uterine Cervical NeoplasmsAkt1 , Apex1 , Car9 , Crebbp , Ep300 , Flt1 , Fos , Kdr , Smad4 , Tert , Tfrc , Vegfa
Uterine NeoplasmsFlt1 , Smad3 , Tert
Uveal MelanomaKdr , Serpine1 , Vegfa
UveitisNos2
Uveitis, AnteriorNos2
Uveomeningoencephalitic SyndromeItgb2
VaricoceleHif1a , Hmox1
Vascular DepressionSerpine1
Vascular DiseasesEpo
Vascular RemodelingSerpine1
Vascular System InjuriesHmox1 , Id2
Vasospasm, IntracranialHmox1
Venous ThromboembolismSerpine1
Venous ThrombosisEpo , Kdr , Mmp14 , Serpine1
Ventilator-Induced Lung InjuryAkt1 , Serpine1
Ventricular DysfunctionAdora2a
Ventricular FibrillationEpo , Hmox1
Ventricular RemodelingSmad3
Ventricular Septal Defect 2Cited2
Vitreoretinopathy, ProliferativeEdn1
VomitingAbcb1a
von Hippel-Lindau DiseaseEpas1 , Vhl
Waldenstrom MacroglobulinemiaCxcr4
Weight GainLep
Weight LossAdora2a , Epo , Lep
Werner SyndromeHif1a
Wet Macular DegenerationFlt1 , Kdr , Vegfa
WHIM SyndromeCxcr4
Wilms TumorAbcb1a , Flt1 , Hif1a , Slc2a1 , Tert , Vhl
Winchester syndromeMmp14
Wounds and InjuriesCxcl12 , Eng , Hmox1 , Vegfa
Wounds, PenetratingCxcl12 , Epo , Serpine1
Pathway Annotations Associated with Genes in the hypoxia inducible factor pathway
Pathway TermsGene Symbols
activin signaling pathwaySmad3
acute intermittent porphyria disease pathwayFech , Hmox1
acute myeloid leukemia pathwayAkt1
adenosine signaling pathwayAdora2a , Akt1 , Creb1 , Elk1 , Jun
aldosterone signaling pathwayCrebbp , Ncoa1 , Ncoa2
altered androgen signaling pathwayNcoa2
altered energy homeostasis pathwayLep
altered ephrin - ephrin receptor bidirectional signaling pathwayEfna1
altered galactose metabolic pathwayHk2
altered hypoxia inducible factor pathwayVhl
altered leptin system pathwayLep
altered p53 signaling pathwayEts1
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1
altered transforming growth factor-beta Smad dependent signaling pathwaySmad3 , Smad4
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expressionKdr , Vegfa
altered vascular endothelial growth factor signaling pathway involving the main playersKdr , Vegfa
amino sugar metabolic pathwayGck , Hk1 , Hk2 , Pgm1
androgen signaling pathwayCrebbp , Ep300 , Ncoa1 , Ncoa2
antigen processing and presentation pathwayCreb1
apoptotic cell death pathwayAkt1
arginine and proline metabolic pathwayNos2 , Sat1 , Sat2
aryl hydrocarbon receptor signaling pathwayArnt , Arnt2
axitinib pharmacodynamics pathwayFlt1 , Kdr
B cell receptor signaling pathwayAkt1 , Fos , Jun
base excision repair pathwayApex1
bevacizumab pharmacodynamics pathwayFlt1 , Kdr , Vegfa
bile acid transport pathwayAbcb1a , Abcg2 , Slc2a1
bladder cancer pathwayVegfa
Bone morphogenetic proteins signaling pathwaySmad4
butirosin and neomycin biosynthetic pathwayGck , Hk1 , Hk2
calcium/calcium-mediated signaling pathwayAdora2a , Nos2
cell cycle pathway, mitoticCrebbp , Ep300 , Rbx1 , Smad3 , Smad4
ceramide signaling pathwayAkt1 , Smad3 , Smad4 , Vegfa
chemokine mediated signaling pathwayAkt1 , Cxcl12 , Cxcr4
chronic myeloid leukemia pathwayAkt1 , Smad3 , Smad4
clopidogrel pharmacodynamics pathwayAbcb1a
clopidogrel pharmacokinetics pathwayAbcb1a
coagulation cascade pathwaySerpine1
colorectal cancer pathwayAkt1 , Fos , Jun , Smad3 , Smad4
complement system pathwaySerpine1
cortisol signaling pathwayCrebbp , Ep300 , Ncoa1 , Ncoa2
cysteine and methionine metabolic pathwayLdha
cytokine mediated signaling pathwayCxcl12 , Cxcr4 , Epo , Flt1 , Kdr , Lep
docetaxel pharmacodynamics pathwayAbcb1a , Abcg2
doxorubicin pharmacokinetics pathwayAbcb1a , Abcg2
E-cadherin signaling pathwayAkt1 , Efna1
eicosanoid signaling pathwayAkt1
endocytosis pathwayCxcr4 , Flt1 , Kdr , Smad3 , Tfrc
endometrial cancer pathwayAkt1 , Elk1
Endoplasmic Reticulum-associated degradation pathwayOs9 , Rbx1
endothelin signaling pathwayAkt1 , Edn1 , Fos , Jun , Nos2
energy homeostasis pathwayLep
Entamoeba histolyca infection pathwayItgb2 , Nos2
ephrin - ephrin receptor bidirectional signaling axisCxcr4 , Efna1 , Tf
epidermal growth factor/neuregulin signaling pathwayAkt1 , Elk1 , Jun
erlotinib pharmacodynamics pathwayAbcb1a , Abcg2
erythropoietic porphyria disease pathwayFech , Hmox1
erythropoietin signaling pathwayEpo
estrogen signaling pathwayCrebbp , Ep300 , Ncoa1 , Ncoa2
etoposide pharmacodynamics pathwayAbcb1a
etoposide pharmacokinetics pathwayAbcb1a
facilitative sugar transporter mediated glucose transport pathwaySlc2a1
fanconi syndrome pathwayAldoa , Eno1 , Hk2
FasL mediated signaling pathwayAkt1
Fc epsilon receptor mediated signaling pathwayAkt1
Fc gamma receptor mediated signaling pathwayAkt1
fibrinolysis pathwaySerpine1
fibroblast growth factor signaling pathwayAkt1 , Fos , Jun
follicle-stimulating hormone signaling pathwayCreb1
forkhead class A signaling pathwayAkt1 , Creb1 , Crebbp , Ep300 , Fos , Gck , Hnf4a , Igfbp1 , Jun , Sp1 , Tfrc
french type sialuria disease pathwayHk1
fructose and mannose metabolic pathwayAldoa , Hk1 , Hk2 , Pfkfb3 , Pfkl
fructose intolerance pathwayAldoa , Hk1 , Pfkl
fructose-1,6-diphosphatase deficiency pathwayAldoa , Eno1 , Hk2 , Pgm1
fructosuria disease pathwayAldoa , Hk1 , Pfkl
galactose metabolic pathwayGck , Hk1 , Hk2 , Pfkl , Pgm1
GALE deficiency pathwayGck , Pgm1
GALK deficiency pathwayGck , Pgm1
GALT deficiency pathwayGck , Hk1 , Pgm1
glioma pathwayAkt1
gluconeogenesis pathwayAldoa , Eno1 , Gck , Hk1 , Hk2 , Ldha , Pfkl , Pgk1 , Pgm1
Glut1 deficiency syndrome pathwaySlc2a1
glycogen biosynthetic pathwayGck , Pgm1
glycogen degradation pathwayPgm1
glycogen metabolic pathwayGck
glycogen storage disease pathway, type IAAldoa , Eno1 , Hk2 , Pgm1
glycogen storage disease pathway, type IBAldoa , Eno1 , Hk2 , Pgm1
glycogen storage disease pathway, type IIIGck , Hk2 , Pgm1
glycogen storage disease pathway, type IV.Gck , Hk2 , Pgm1
glycogen storage disease pathway, type VIGck , Hk2 , Pgm1
glycogen storage disease pathway, type VIIAldoa , Eno1 , Hk2
glycolysis pathwayAldoa , Eno1 , Gck , Hk1 , Hk2 , Ldha , Pfkfb3 , Pfkl , Pgk1 , Pgm1 , Pkm
glycolysis/gluconeogenesis pathwayAldoa , Eno1 , Gck , Hk1 , Hk2 , Ldha , Pfkl , Pgk1 , Pgm1
glypican signaling pathwayFlt1 , Furin , Vegfa
gonadotropin-releasing hormone signaling pathwayElk1 , Jun , Mmp14
granulocyte-macrophage colony-stimulating factor signaling pathwayFos
Hedgehog signaling pathwayAkt1 , Crebbp
heme biosynthetic pathwayFech
heme degradation pathwayHmox1
hepatitis C virus infection pathwayAkt1 , Eif3el1
hereditary coproporhyria disease pathwayFech , Hmox1
histamine signaling pathway, immunologicalCreb1
histone modification pathwayCrebbp , Ep300 , Hdac7
Huntington disease pathwayCreb1 , Crebbp , Ep300 , Sp1
hypertension pathwayHmox1
hypoxia inducible factor pathwayAbcb1a , Abcg2 , Adm , Adora2a , Akt1 , Aldoa , Apex1 , Arnt , Arnt2 , Bhlhe40 , Bhlhe41 , Bnip3 , Car9 , Cited2 , Cops5 , Cp , Creb1 , Crebbp , Cul2 , Cxcl12 , Cxcr4 , Edn1 , Efna1 , Egln1 , Egln2 , Egln3 , Eif3el1 , Elk1 , Elob , Eloc , Eng , Eno1 , Ep300 , Epas1 , Epo , Ets1 , Fech , Flt1 , Fos , Furin , Fxn , Gata2 , Gck , Hdac7 , Hif1a , Hif1an , Hif3a , Hk1 , Hk2 , Hmox1 , Hnf4a , Id2 , Igfbp1 , Itgb2 , Jun , Kdr , Ldha , Lep , Mcl1 , Mmp14 , Ncoa1 , Ncoa2 , Ndrg1 , Nos2 , Npm1 , Nt5e , Os9 , Pfkfb3 , Pfkl , Pgk1 , Pgm1 , Pkm , Plin2 , Pou5f1 , Rack1 , Rbx1 , Sat1 , Sat2 , Serpine1 , Slc11a2 , Slc2a1 , Smad3 , Smad4 , Sp1 , Tert , Tf , Tff3 , Tfrc , Twist1 , Vegfa , Vhl
inflammatory response pathwayEdn1
influenza A virus infection pathwayAkt1 , Crebbp , Ep300 , Furin , Jun
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1
insulin secretion pathwayGck
insulin signaling pathwayAkt1 , Elk1 , Gck , Hk1 , Hk2
insulin-like growth factor signaling pathwayAkt1 , Igfbp1 , Rack1
integrin mediated signaling pathwayItgb2
interleukin-1 signaling pathwayJun
interleukin-12 signaling pathwayFos , Nos2
interleukin-2 signaling pathwayFos , Jun
interleukin-23 signaling pathwayNos2
interleukin-4 signaling pathwayAkt1 , Ets1 , Sp1 , Tff3
interleukin-6 signaling pathwayAkt1 , Fos , Jun , Mcl1
intrinsic apoptotic pathwayBnip3 , Mcl1
irinotecan pharmacodynamics pathwayAbcb1a , Abcg2
irinotecan pharmacokinetics pathwayAbcb1a , Abcg2
iron efflux pathwayCp
iron uptake pathwaySlc11a2 , Tf , Tfrc
Jak-Stat signaling pathwayAkt1 , Crebbp , Ep300 , Epo , Lep
lactose biosynthetic pathwaySlc2a1
lamivudine pharmacokinetics pathwayAbcb1a , Abcg2 , Pgk1
Leishmania infection pathwayElk1 , Fos , Itgb2 , Jun , Nos2
leptin system pathwayLep
long term potentiationCrebbp , Ep300
luteinizing hormone signaling pathwayCreb1
maturity onset diabetes of the young pathwayGck , Hnf4a
measles infection pathwayAkt1 , Rack1
melanoma pathwayAkt1
mitochondrial autophagy pathwayBnip3
mitogen activated protein kinase signaling pathwayAkt1 , Elk1 , Fos , Jun
monoterpenoid biosynthetic pathwayNt5e
mTOR signaling pathwayAkt1 , Bnip3 , Hif1a , Vegfa
Mycobacterium tuberculosis infection pathwayAkt1 , Creb1 , Crebbp , Ep300 , Itgb2 , Nos2
mycophenolic acid pharmacokinetics pathwayAbcb1a , Abcg2
myocarditis pathwayItgb2
neddylation pathwayCul2 , Rbx1
neurotrophic factor signaling pathwayAkt1 , Jun
niacin metabolic pathwayNt5e
non-small cell lung cancer pathwayAkt1
Notch signaling pathwayCrebbp , Eno1 , Ep300 , Furin
nuclear factor kappa B signaling pathwayRbx1
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp , Rbx1
nucleotide excision repair pathwayRbx1
nucleotide sugar metabolic pathwayGck , Hk1 , Hk2 , Pgm1
oxygen homeostasis pathwaySerpine1
p38 MAPK signaling pathwayAdm
p53 signaling pathwayAkt1 , Crebbp , Ep300 , Serpine1
pancreatic cancer pathwayAkt1 , Smad3 , Smad4 , Vegfa
paracetamol pharmacokinetics pathwayAbcb1a , Abcg2
pentose phosphate pathwayAldoa , Pfkl , Pgm1
phagocytosis pathwayItgb2 , Tfrc
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1
phosphoenolpyruvate carboxykinase deficiency pathwayAldoa , Eno1 , Hk2 , Pgm1
Plasmodium infection pathwayItgb2
platelet-derived growth factor signaling pathwayElk1 , Fos , Jun
polyamine metabolic pathwaySat1
porphyria variegata disease pathwayFech , Hmox1
porphyrin and chlorophyll metabolic pathwayCp , Fech , Hmox1
porphyrin metabolic pathwayFech , Hmox1
prion diseases pathwayElk1
propanoate metabolic pathwayLdha
prostate cancer pathwayAkt1 , Creb1 , Crebbp , Ep300 , Ncoa2
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul2 , Rbx1 , Vhl
protein kinase C (PKC) signaling pathwayRack1
purine metabolic pathwayNt5e , Pgm1
pyrimidine metabolic pathwayNt5e
pyruvate metabolic pathwayLdha , Pkm
Reelin signaling pathwayAkt1
renal cell cancer pathwayAkt1 , Arnt , Arnt2 , Crebbp , Cul2 , Egln1 , Egln2 , Egln3 , Elob , Eloc , Ep300 , Epas1 , Ets1 , Hif1a , Jun , Rbx1 , Slc2a1 , Vegfa , Vhl
retinoic acid signaling pathwayNcoa1 , Ncoa2
rheumatoid arthritis disease pathwayCxcl12 , Flt1 , Fos , Itgb2 , Jun , Vegfa
Rho/Rac/Cdc42 mediated signaling pathwayJun
ribose 5-phosphate isomerase deficiency pathwayAldoa , Pfkl , Pgm1
ribosome biogenesis pathwayRack1
RNA degradation pathwayEno1
RNA polymerase I transcription pathwayCrebbp
RNA transport pathwayEif3el1
serotonin signaling pathway via receptors engaging G alphas protein familyCreb1
sialic acid storage disease pathwayHk1
small cell lung cancer pathwayAkt1 , Nos2
spermidine metabolic pathwaySat1
spermine metabolic pathwaySat1
sphingosine 1-phosphate signaling pathwayAkt1 , Cxcr4 , Elk1 , Flt1 , Fos , Jun , Kdr , Vegfa
Staphylococcus aureus infection pathwayItgb2
starch and sucrose metabolic pathwayGck , Hk1 , Hk2 , Pgm1
Sucrase-isomaltase deficiency pathwayGck , Hk2 , Pgm1
syndecan signaling pathwayCxcl12 , Cxcr4 , Rack1
T cell receptor signaling pathwayAkt1 , Fos , Jun
Tay-Sachs disease pathwayHk1
Toll-like receptor signaling pathwayAkt1 , Fos , Jun
Toxoplasma gondii infection pathwayAkt1 , Nos2
transaldolase deficiency pathwayAldoa , Pfkl , Pgm1
transforming growth factor-beta Smad dependent signaling pathwayCreb1 , Crebbp , Smad3 , Smad4
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300 , Id2 , Rbx1 , Smad3 , Smad4 , Sp1
translation initiation pathwayEif3el1
trehalose degradation pathwayGck
triosephosphate isomerase deficiency pathwayAldoa , Eno1 , Hk2 , Pgm1
Trypanosoma cruzi infection pathwayAkt1 , Fos , Jun , Nos2 , Serpine1 , Smad3
tumor necrosis factor mediated signaling pathwayRack1
type 2 diabetes mellitus pathwayGck , Hk1 , Hk2
type II interferon signaling pathwayAkt1 , Crebbp , Ep300
tyrosinemia type III disease pathwayAbcb1a , Abcg2
ubiquitin/proteasome degradation pathwayCul2 , Elob , Eloc , Rbx1 , Vhl
vascular endothelial growth factor signaling pathwayAkt1 , Egln1 , Egln2 , Egln3 , Flt1 , Hif1a , Kdr , Vegfa
vasopressin signaling pathway via receptor type 2Creb1
venlafaxine pharmacokinetics pathwayAbcb1a
vinblastine pharmacodynamics pathwayAbcb1a
vincristine pharmacodynamics pathwayAbcb1a
vindesine pharmacodynamics pathwayAbcb1a
vinorelbine pharmacodynamics pathwayAbcb1a
Wnt signaling pathwayCrebbp , Ep300 , Jun , Rbx1 , Smad3 , Smad4
Wnt signaling, canonical pathwayCrebbp
Phenotype Annotations Associated with Genes in the hypoxia inducible factor pathway

References Associated with the hypoxia inducible factor pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: