Gene: Smad3 (SMAD family member 3) Rattus norvegicus
Symbol: Smad3
Name: SMAD family member 3
Description: ENCODES a protein that exhibits DNA binding; enzyme binding; sequence-specific DNA binding; INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; negative regulation of apoptotic process; negative regulation of cell proliferation; PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; ASSOCIATED WITH liver fibrosis; ASSOCIATED WITH Aneurysm, Dissecting (ortholog); Colorectal Neoplasms, Hereditary Nonpolyposis (ortholog); Endometrial Neoplasms (ortholog); FOUND IN cytoplasm; nucleus; protein complex; INTERACTS WITH 2-acetamidofluorene; 5-aza-2'-deoxycytidine; benazepril
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MAD (mothers against decapentaplegic Drosophila) homolog 3; MAD (mothers against decapentaplegic, Drosophila) homolog 3; MAD homolog 3; MAD homolog 3 (Drosophila); mad3; Madh3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; Smad 3
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Celera863,537,497 - 63,647,062 (-)NCBI
Cytogenetic Map8q24NCBImapview
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Smad3
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 3032
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2016-04-19
Status: ACTIVE