Gene: Smad3 (SMAD family member 3) Rattus norvegicus
Symbol: Smad3
Name: SMAD family member 3
Description: ENCODES a protein that exhibits DNA binding; enzyme binding; sequence-specific DNA binding; INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; negative regulation of apoptotic process; negative regulation of cell proliferation; PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; ASSOCIATED WITH liver fibrosis; ASSOCIATED WITH Aneurysm, Dissecting (ortholog); Colorectal Neoplasms, Hereditary Nonpolyposis (ortholog); Endometrial Neoplasms (ortholog); FOUND IN cytoplasm; nucleus; protein complex; INTERACTS WITH 2-acetamidofluorene; 5-aza-2'-deoxycytidine; benazepril
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MAD (mothers against decapentaplegic Drosophila) homolog 3; MAD (mothers against decapentaplegic, Drosophila) homolog 3; MAD homolog 3; MAD homolog 3 (Drosophila); mad3; Madh3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; Smad 3
Latest Assembly: RGSC Genome Assembly v5.0
RGSC Genome Assembly v6.0868,569,530 - 68,678,349-NCBI
Rat Cytogenetic Map8q24 NCBI
RGSC Genome Assembly v5.0868,290,927 - 68,397,727-NCBI
RGSC Genome Assembly v3.4867,803,909 - 67,952,056-NCBI
Rat Celera Assembly863,537,497 - 63,647,062-NCBI
Genome Assembly 3.1867,822,964 - 67,971,110-NCBI

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Comparative Map Data
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QTLs in Region (RGSC Genome Assembly v5.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Smad3
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RGD Object Information
RGD ID: 3032
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2016-02-02
Status: ACTIVE