Gene: Smad3 (SMAD family member 3) Rattus norvegicus
Symbol: Smad3
Name: SMAD family member 3
Description: ENCODES a protein that exhibits beta-catenin binding; DNA binding; enzyme binding; INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; canonical Wnt signaling pathway; negative regulation of apoptotic process; PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; ASSOCIATED WITH liver fibrosis; ASSOCIATED WITH Aneurysm, Dissecting (ortholog); Aortic Aneurysm (ortholog); Aortic Aneurysm, Thoracic (ortholog); FOUND IN cytoplasm; nucleus; protein complex; INTERACTS WITH 2-acetamidofluorene; 5-aza-2'-deoxycytidine; arsane
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MAD (mothers against decapentaplegic Drosophila) homolog 3; MAD (mothers against decapentaplegic, Drosophila) homolog 3; MAD homolog 3; MAD homolog 3 (Drosophila); mad3; Madh3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; Smad 3
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Celera863,537,497 - 63,647,062 (-)NCBI
Cytogenetic Map8q24NCBImapview

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Smad3
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 3032
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2016-10-11
Status: ACTIVE