RGD Reference Report - Ovarian follicle populations of the rat express TGF-beta signalling pathways. - Rat Genome Database

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Ovarian follicle populations of the rat express TGF-beta signalling pathways.

Authors: Drummond, AE  Dyson, M  Le, MT  Ethier, JF  Findlay, JK 
Citation: Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
RGD ID: 1559169
Pubmed: PMID:12770730   (View Abstract at PubMed)

The transforming growth factor-beta (TGF-beta) superfamily comprises more than 40 members, classified on the basis of structural similarity. These factors elicit a diverse range of cellular responses in insects, nematodes and vertebrates, via serine/threonine kinase receptors and intracellular Smad proteins, which when activated mediate gene transcription. Some members of the superfamily, notably activin, TGF-beta, GDF-9 and the bone morphogenetic proteins have been shown to influence ovarian function. Despite these actions, TGF-beta superfamily signalling pathways and specifically those within follicle population subtypes, have been poorly characterised in the ovary. We have shown that the ovary contains type I and II receptors and Smads, which enable it to transduce signals in response to TGF-beta superfamily members. It remains to be established however, as to which follicle subtypes these pathways are active in.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein phosphorylation  TAS 1559169; 1559169; 1559169; 1559169; 1559169 RGD 

Molecular Function

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Acvr1  (activin A receptor type 1)
Acvr1b  (activin A receptor type 1B)
Acvr2a  (activin A receptor type 2A)
Acvr2b  (activin A receptor type 2B)
Acvrl1  (activin A receptor like type 1)
Smad2  (SMAD family member 2)
Smad3  (SMAD family member 3)

Genes (Mus musculus)
Acvr1  (activin A receptor, type 1)
Acvr1b  (activin A receptor, type 1B)
Acvr2a  (activin receptor IIA)
Acvr2b  (activin receptor IIB)
Acvrl1  (activin A receptor, type II-like 1)
Smad2  (SMAD family member 2)
Smad3  (SMAD family member 3)

Genes (Homo sapiens)
ACVR1  (activin A receptor type 1)
ACVR1B  (activin A receptor type 1B)
ACVR2A  (activin A receptor type 2A)
ACVR2B  (activin A receptor type 2B)
ACVRL1  (activin A receptor like type 1)
SMAD2  (SMAD family member 2)
SMAD3  (SMAD family member 3)


Additional Information