GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Smad3 | increases expression | EXP | | 6480464 | CTD | Ethanol results in increased expression of SMAD3 protein | PMID:23274713 | Smad3 | increases phosphorylation | EXP | | 6480464 | CTD | Ethanol results in increased phosphorylation of SMAD3 protein | PMID:21172400 PMID:22063920 | Smad3 | multiple interactions | EXP | | 6480464 | CTD | 8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein]; [Carbon Tetrachloride co-treated with Ethanol] results in increased phosphorylation of SMAD3 protein; betulin inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein]; Betulinic Acid inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein]; Genistein inhibits the reaction [Ethanol results in increased expression of SMAD3 protein]; methyl ferulate inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased phosphorylation of SMAD3 protein] | PMID:21172400 PMID:22063920 PMID:23274713 PMID:30543783 | Smad3 | affects splicing | ISO | Smad3 (Mus musculus) | 6480464 | CTD | Ethanol affects the splicing of SMAD3 mRNA | PMID:30319688 | Smad3 | increases expression | ISO | SMAD3 (Homo sapiens) | 6480464 | CTD | Ethanol results in increased expression of SMAD3 mRNA | PMID:23378141 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |