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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad3
Name: SMAD family member 3
Acc ID: CHEBI:15343
Term: acetaldehyde
Definition: The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
Chemical ID: MESH:D000079
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad3increases phosphorylationISOSMAD3 (Homo sapiens)6480464CTDAcetaldehyde results in increased phosphorylation of SMAD3 proteinPMID:16025520
Smad3multiple interactionsISOSMAD3 (Homo sapiens)6480464CTDSMAD3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]PMID:16025520
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