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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad3
Name: SMAD family member 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad3multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SMAD3 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SMAD3 mRNA; [Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of SMAD3 mRNA; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SMAD3 mRNAPMID:18711122
Smad3affects methylationISOSMAD3 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of SMAD3 promoterPMID:27901495 PMID:30157460
Smad3increases expressionISOSmad3 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of SMAD3 mRNAPMID:22228805
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