Gene: Smad3 (SMAD family member 3)  Mus musculus Symbol: Smad3 Name: SMAD family member 3 Description: ENCODES a protein that exhibits chromatin binding; chromatin DNA binding; collagen binding; INVOLVED IN developmental growth; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; PARTICIPATES IN activin signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; ASSOCIATED WITH abnormal anterior definitive endoderm morphology; abnormal articular cartilage morphology; abnormal B cell proliferation; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Colorectal Neoplasms, Hereditary Nonpolyposis (ortholog); Endometrial Neoplasms (ortholog); FOUND IN cytoplasm; nucleus; plasma membrane; INTERACTS WITH (S)-nicotine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17alpha-ethynylestradiol Type: protein-coding RefSeq Status: VALIDATED Also known as: AU022421; MAD homolog 3; mad3; Madh3; mMad3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; OTTMUSP00000023917; OTTMUSP00000023918; Smad 3; SMAD family member 3 Orthologs: Homo sapiens : SMAD3 (SMAD family member 3)  HGNC Rattus norvegicus : Smad3 (SMAD family member 3) Latest Assembly: Mouse Genome Assembly Build 37 Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 9 63,646,767 - 63,757,994 - NCBI Mouse cM Map 9   - NCBI Mouse Celera Assembly 9 60,869,117 - 60,980,879 - NCBI Mouse Genome Assembly Build 37 9 63,494,574 - 63,605,801 - NCBI Mouse Genome Assembly Build 36.1 9 63,494,574 - 63,605,801 - NCBI Mouse Cytogenetic Map 9 D   NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Colorectal Neoplasms   ISS RGD:1343311 2306282   RGD   Colorectal Neoplasms, Hereditary Nonpolyposis   ISS RGD:1343311 1599900   RGD   Endometrial Neoplasms   ISS RGD:1343311 2299970 protein:increased expression:endometrium RGD   Prostatic Neoplasms Disease_progression ISS RGD:1343311 2300396   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1343311 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD3 mRNA CTD PMID:22079256 (S)-nicotine multiple interactions EXP   6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMAD3 mRNA; more ... CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression EXP   6480464 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions EXP   6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD3 mRNA; more ... CTD PMID:20230807 17alpha-ethynylestradiol decreases expression EXP   6480464 Ethinyl Estradiol results in decreased expression of SMAD3 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions EXP   6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNA CTD PMID:17942748 17beta-estradiol affects expression ISO RGD:1343311 6480464 Estradiol affects the expression of SMAD3 mRNA CTD PMID:14699072 17beta-estradiol decreases expression ISO RGD:1343311 6480464 Estradiol results in decreased expression of SMAD3 mRNA CTD PMID:19167446 17beta-estradiol affects expression ISO RGD:1343311 6480464 Estradiol affects the expression of SMAD3 mRNA CTD PMID:14699072 PMID:22574217 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1343311 6480464 Dihydrotestosterone results in increased expression of SMAD3 mRNA CTD PMID:16597033 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP   6480464 Tetrachlorodibenzodioxin affects the expression of SMAD3 mRNA CTD PMID:21570461 2-acetamidofluorene multiple interactions ISO RGD:3032 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein; more ... CTD PMID:15368444 3,4-dihydroxybenzaldehyde multiple interactions ISO RGD:1343311 6480464 protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein]; more ... CTD PMID:17597607 3,4-methylenedioxymethamphetamine increases expression EXP   6480464 N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SMAD3 mRNA CTD PMID:20188158 4-vinylcyclohexene dioxide affects expression EXP   6480464 4-vinyl-1-cyclohexene dioxide affects the expression of SMAD3 mRNA CTD PMID:20829426 9-cis-retinoic acid multiple interactions EXP   6480464 [TO-901317 co-treated with alitretinoin] results in increased expression of SMAD3 protein CTD PMID:17194744 acetaldehyde multiple interactions ISO RGD:1343311 6480464 SMAD3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] CTD PMID:16025520 acetaldehyde increases phosphorylation ISO RGD:1343311 6480464 Acetaldehyde results in increased phosphorylation of SMAD3 protein CTD PMID:16025520 aflatoxin B1 increases expression ISO RGD:1343311 6480464 Aflatoxin B1 results in increased expression of SMAD3 mRNA CTD PMID:21641981 aflatoxin B1 increases expression ISO RGD:1343311 6480464 Aflatoxin B1 results in increased expression of SMAD3 mRNA CTD PMID:21641981 PMID:22100608 all-trans-retinoic acid multiple interactions ISO RGD:1343311 6480464 Tamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD3 protein] CTD PMID:17098229 all-trans-retinoic acid increases expression ISO RGD:1343311 6480464 Tretinoin results in increased expression of SMAD3 mRNA CTD PMID:16012519 PMID:17431108 all-trans-retinoic acid decreases phosphorylation EXP   6480464 Tretinoin results in decreased phosphorylation of SMAD3 protein CTD PMID:16410076 all-trans-retinoic acid increases phosphorylation ISO RGD:1343311 6480464 Tretinoin results in increased phosphorylation of SMAD3 protein CTD PMID:17098229 all-trans-retinoic acid increases expression ISO RGD:1343311 6480464 Tretinoin results in increased expression of SMAD3 mRNA CTD PMID:17431108 PMID:16012519 benazepril affects expression ISO RGD:3032 6480464 benazepril affects the expression of SMAD3 mRNA; more ... CTD PMID:16635409 benazepril multiple interactions ISO RGD:3032 6480464 [benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein CTD PMID:19487956 benazepril multiple interactions ISO RGD:3032 6480464 [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA; more ... CTD PMID:16635409 benzo[a]pyrene multiple interactions EXP   6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of SMAD3 mRNA CTD PMID:21715664 benzo[a]pyrene multiple interactions ISO RGD:3032 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SMAD3 mRNA; more ... CTD PMID:18711122 benzo[a]pyrene increases expression EXP   6480464 Benzo(a)pyrene results in increased expression of SMAD3 mRNA CTD PMID:22228805 benzo[b]fluoranthene multiple interactions ISO RGD:3032 6480464 [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SMAD3 mRNA CTD PMID:18711122 betulin multiple interactions ISO RGD:3032 6480464 betulin inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 betulinic acid multiple interactions ISO RGD:3032 6480464 betulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 bis(2-chloroethyl) sulfide decreases expression EXP   6480464 Mustard Gas results in decreased expression of SMAD3 mRNA CTD PMID:15674843 caffeine multiple interactions EXP   6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD3 mRNA; more ... CTD PMID:20230807 candesartan multiple interactions ISO RGD:3032 6480464 [benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein CTD PMID:19487956 CGS-21680 multiple interactions ISO RGD:3032 6480464 8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of SMAD3 protein] CTD PMID:22063920 cholesterol multiple interactions EXP   6480464 [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of SMAD3 mRNA CTD PMID:22129739 choline multiple interactions EXP   6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene CTD PMID:20938992 cisplatin decreases expression ISO RGD:1343311 6480464 Cisplatin results in decreased expression of SMAD3 mRNA CTD PMID:19561079 copper(2+) sulfate increases expression ISO RGD:1343311 6480464 Copper Sulfate results in increased expression of SMAD3 mRNA CTD PMID:19549813 coumestrol decreases expression ISO RGD:1343311 6480464 Coumestrol results in decreased expression of SMAD3 mRNA CTD PMID:19167446 coumestrol multiple interactions ISO RGD:1343311 6480464 [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD3 mRNA CTD PMID:19167446 curcumin multiple interactions ISO RGD:3032 6480464 Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter] CTD PMID:16959952 D-glucose multiple interactions ISO RGD:1343311 6480464 Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein; more ... CTD PMID:17597607 dexamethasone affects expression EXP   6480464 Dexamethasone affects the expression of SMAD3 mRNA CTD PMID:21277400 diarsenic trioxide decreases response to substance ISO RGD:1343311 6480464 SMAD3 protein results in decreased susceptibility to arsenic trioxide CTD PMID:20707922 dibenz[a,h]anthracene multiple interactions ISO RGD:3032 6480464 [Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SMAD3 mRNA CTD PMID:18711122 dibenzo[a,l]pyrene multiple interactions ISO RGD:3032 6480464 [Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of SMAD3 mRNA CTD PMID:18711122 dibutyl phthalate increases expression EXP   6480464 Dibutyl Phthalate results in increased expression of SMAD3 mRNA CTD PMID:21266533 disodium selenite increases expression ISO RGD:1343311 6480464 Sodium Selenite results in increased expression of SMAD3 mRNA CTD PMID:18175754 doxorubicin multiple interactions ISO RGD:1343311 6480464 Doxorubicin inhibits the reaction [TGFB1 protein results in increased localization of SMAD3 protein] CTD PMID:18606404 doxorubicin decreases expression ISO RGD:1343311 6480464 Doxorubicin results in decreased expression of SMAD3 protein CTD PMID:18606404 ethanol multiple interactions ISO RGD:3032 6480464 betulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein]; more ... CTD PMID:21172400 ethanol multiple interactions ISO RGD:3032 6480464 8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:22063920 ethanol increases phosphorylation ISO RGD:3032 6480464 Ethanol results in increased phosphorylation of SMAD3 protein CTD PMID:21172400 PMID:22063920 ethanol increases phosphorylation ISO RGD:3032 6480464 Ethanol results in increased phosphorylation of SMAD3 protein CTD PMID:21172400 fenofibrate multiple interactions ISO RGD:1343311 6480464 Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]; more ... CTD PMID:19593819 fluoranthene multiple interactions ISO RGD:3032 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SMAD3 mRNA CTD PMID:18711122 folic acid multiple interactions EXP   6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene CTD PMID:20938992 glucose multiple interactions ISO RGD:1343311 6480464 Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein; more ... CTD PMID:17597607 hydrogen peroxide increases phosphorylation ISO RGD:1343311 6480464 Hydrogen Peroxide results in increased phosphorylation of SMAD3 protein CTD PMID:15147944 hydrogen peroxide increases secretion EXP   6480464 Hydrogen Peroxide results in increased secretion of SMAD3 mRNA CTD PMID:21179422 irbesartan multiple interactions ISO RGD:3032 6480464 [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA; more ... CTD PMID:16635409 irbesartan affects expression ISO RGD:3032 6480464 irbesartan affects the expression of SMAD3 mRNA; more ... CTD PMID:16635409 L-methionine multiple interactions EXP   6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene CTD PMID:20938992 lycopene increases expression ISO RGD:1343311 6480464 lycopene results in increased expression of SMAD3 mRNA CTD PMID:16886892 melphalan decreases expression ISO RGD:1343311 6480464 Melphalan results in decreased expression of SMAD3 mRNA CTD PMID:22363485 menadione affects expression ISO RGD:1343311 6480464 Vitamin K 3 affects the expression of SMAD3 mRNA CTD PMID:20044591 methylmercury chloride increases expression EXP   6480464 methylmercuric chloride results in increased expression of SMAD3 mRNA CTD PMID:20061341 N-nitrosodiethylamine multiple interactions ISO RGD:3032 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein; more ... CTD PMID:15368444 N-nitrosodiethylamine affects phosphorylation ISO RGD:3032 6480464 Diethylnitrosamine affects the phosphorylation of SMAD3 protein CTD PMID:19418558 N-nitrosodiethylamine multiple interactions ISO RGD:3032 6480464 anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Diethylnitrosamine affects the phosphorylation of SMAD3 protein] CTD PMID:19418558 nitric oxide multiple interactions ISO RGD:3032 6480464 [SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxide; more ... CTD PMID:15949472 paracetamol increases expression EXP   6480464 Acetaminophen results in increased expression of SMAD3 mRNA CTD PMID:11752693 paracetamol increases expression ISO RGD:1343311 6480464 Acetaminophen results in increased expression of SMAD3 mRNA CTD PMID:22230336 paracetamol decreases expression ISO RGD:1343311 6480464 Acetaminophen results in decreased expression of SMAD3 mRNA CTD PMID:21420995 paracetamol affects expression EXP   6480464 Acetaminophen affects the expression of SMAD3 mRNA CTD PMID:17562736 paraquat increases response to substance EXP   6480464 SMAD3 protein results in increased susceptibility to Paraquat CTD PMID:22581813 perindopril multiple interactions ISO RGD:3032 6480464 Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:16872305 perindopril decreases expression ISO RGD:3032 6480464 Perindopril results in decreased expression of SMAD3 protein CTD PMID:15619341 pirinixic acid decreases expression EXP   6480464 pirinixic acid results in decreased expression of SMAD3 mRNA CTD PMID:20813756 resveratrol multiple interactions ISO RGD:3032 6480464 resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD3 protein] CTD PMID:21300041 resveratrol decreases acetylation ISO RGD:3032 6480464 resveratrol results in decreased acetylation of SMAD3 protein CTD PMID:20651248 resveratrol decreases acetylation EXP   6480464 resveratrol results in decreased acetylation of SMAD3 protein CTD PMID:20651248 resveratrol decreases expression ISO RGD:1343311 6480464 resveratrol results in decreased expression of SMAD3 protein CTD PMID:18089832 resveratrol decreases phosphorylation EXP   6480464 resveratrol results in decreased phosphorylation of SMAD3 protein CTD PMID:21679764 rosiglitazone decreases expression ISO RGD:3032 6480464 rosiglitazone results in decreased expression of SMAD3 mRNA CTD PMID:21515302 sevoflurane multiple interactions EXP   6480464 TGFB1 protein affects the reaction [sevoflurane affects the localization of SMAD3 protein] CTD PMID:18434384 sevoflurane affects response to substance EXP   6480464 SMAD3 protein affects the susceptibility to sevoflurane CTD PMID:18434384 silver(1+) nitrate decreases expression ISO RGD:1343311 6480464 Silver Nitrate analog results in decreased expression of SMAD3 mRNA CTD PMID:22831968 silver(1+) nitrate increases expression ISO RGD:1343311 6480464 Silver Nitrate results in increased expression of SMAD3 mRNA CTD PMID:22831968 simvastatin increases expression EXP   6480464 Simvastatin results in increased expression of SMAD3 mRNA CTD PMID:18310456 simvastatin decreases phosphorylation ISO RGD:3032 6480464 Simvastatin results in decreased phosphorylation of SMAD3 protein CTD PMID:19659652 streptozocin multiple interactions ISO RGD:3032 6480464 resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD3 protein] CTD PMID:21300041 streptozocin increases phosphorylation ISO RGD:3032 6480464 Streptozocin results in increased phosphorylation of SMAD3 protein CTD PMID:21300041 tamoxifen multiple interactions ISO RGD:1343311 6480464 Tamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD3 protein] CTD PMID:17098229 tamoxifen increases phosphorylation ISO RGD:1343311 6480464 Tamoxifen results in increased phosphorylation of SMAD3 protein CTD PMID:17098229 testosterone increases expression EXP   6480464 Testosterone results in increased expression of SMAD3 mRNA CTD PMID:22138414 tetrachloromethane multiple interactions EXP   6480464 Carbon Tetrachloride inhibits the reaction [HGF protein affects the localization of SMAD3 protein] CTD PMID:18395096 tetrachloromethane increases expression ISO RGD:3032 6480464 Carbon Tetrachloride results in increased expression of SMAD3 protein CTD PMID:15818738 more ... tetrachloromethane increases expression ISO RGD:3032 6480464 Carbon Tetrachloride results in increased expression of SMAD3 protein CTD PMID:16872305 more ... tetrachloromethane multiple interactions ISO RGD:3032 6480464 Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:15818738 PMID:17163593 tetrachloromethane increases expression ISO RGD:3032 6480464 Carbon Tetrachloride results in increased expression of SMAD3 protein CTD PMID:15818738 more ... tetrachloromethane multiple interactions ISO RGD:3032 6480464 valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]; more ... CTD PMID:16872305 tetrachloromethane multiple interactions ISO RGD:3032 6480464 Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:15818738 tetrachloromethane multiple interactions ISO RGD:3032 6480464 Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:17163593 PMID:15818738 tetrachloromethane increases expression ISO RGD:3032 6480464 Carbon Tetrachloride results in increased expression of SMAD3 protein CTD PMID:17163593 more ... tetrachloromethane increases expression ISO RGD:3032 6480464 Carbon Tetrachloride results in increased expression of SMAD3 mRNA CTD PMID:15818738 tetrachloromethane increases activity ISO RGD:3032 6480464 Carbon Tetrachloride results in increased activity of SMAD3 protein CTD PMID:17009398 tetrachloromethane multiple interactions EXP   6480464 oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:18395914 tetrachloromethane affects response to substance EXP   6480464 SMAD3 protein affects the susceptibility to Carbon Tetrachloride CTD PMID:16382155 tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of SMAD3 mRNA CTD PMID:18395914 trans-resveratrol multiple interactions ISO RGD:3032 6480464 resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD3 protein] CTD PMID:21300041 trans-resveratrol decreases acetylation ISO RGD:3032 6480464 resveratrol results in decreased acetylation of SMAD3 protein CTD PMID:20651248 trans-resveratrol decreases acetylation EXP   6480464 resveratrol results in decreased acetylation of SMAD3 protein CTD PMID:20651248 trans-resveratrol decreases expression ISO RGD:1343311 6480464 resveratrol results in decreased expression of SMAD3 protein CTD PMID:18089832 trans-resveratrol decreases phosphorylation EXP   6480464 resveratrol results in decreased phosphorylation of SMAD3 protein CTD PMID:21679764 troglitazone multiple interactions ISO RGD:1343311 6480464 troglitazone inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:18253093 troglitazone decreases expression ISO RGD:3032 6480464 troglitazone results in decreased expression of SMAD3 mRNA CTD PMID:21515302 ursodeoxycholic acid decreases expression ISO RGD:3032 6480464 Ursodeoxycholic Acid results in decreased expression of SMAD3 mRNA; more ... CTD PMID:19493473 valsartan multiple interactions ISO RGD:3032 6480464 valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:16872305 valsartan decreases expression ISO RGD:3032 6480464 valsartan results in decreased expression of SMAD3 protein CTD PMID:15619341 zinc atom multiple interactions EXP   6480464 Zinc promotes the reaction [SMAD3 protein modified form binds to SMAD2 protein modified form binds to NFIC protein] CTD PMID:22228435 zinc(0) multiple interactions EXP   6480464 Zinc promotes the reaction [SMAD3 protein modified form binds to SMAD2 protein modified form binds to NFIC protein] CTD PMID:22228435 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) activation of cysteine-type endopeptidase activity involved in apoptotic process   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 activin receptor signaling pathway   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 cell cycle arrest   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 cell-cell junction organization   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 developmental growth   IGI MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 embryonic cranial skeleton morphogenesis   IGI MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 embryonic foregut morphogenesis   IGI MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 embryonic pattern specification   IGI MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 endoderm development   IGI MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 evasion or tolerance of host defenses by virus   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 gastrulation   IGI MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 heart looping   IGI MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 immune response   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 immune system development   IGI MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 in utero embryonic development   IGI MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 induction of apoptosis   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 lens fiber cell differentiation   IMP   2290270 MGI:MGI:3720408|PMID:17215516 MGI MGI:MGI:3720408 PMID:17215516 liver development   IGI MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 mesoderm formation   IMP MGI:MGI:1857696 2290270 MGI:MGI:3039049|PMID:15084457 MGI MGI:MGI:3039049 PMID:15084457 negative regulation of apoptotic process   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of cell growth   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 negative regulation of cell proliferation   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of inflammatory response   IMP   2290270 MGI:MGI:1352043|PMID:10559937 UniProtKB MGI:MGI:1352043 PMID:10559937 negative regulation of mitotic cell cycle   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 negative regulation of osteoblast differentiation   IGI MGI:MGI:1316736 2290270 MGI:MGI:3056877|PMID:15150273 MGI MGI:MGI:3056877 PMID:15150273 negative regulation of osteoblast proliferation   IMP   2290270 MGI:MGI:5285145|PMID:21035443 UniProtKB MGI:MGI:5285145 PMID:21035443 negative regulation of protein catabolic process   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 negative regulation of protein phosphorylation   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 negative regulation of transcription from RNA polymerase II promoter   IDA   2290270 MGI:MGI:1276222|PMID:9702197 MGI MGI:MGI:1276222 PMID:9702197 negative regulation of transcription from RNA polymerase II promoter   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 negative regulation of transcription from RNA polymerase II promoter   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of transcription from RNA polymerase II promoter   IDA   2290270 MGI:MGI:2153314|PMID:11711431 MGI MGI:MGI:2153314 PMID:11711431 negative regulation of wound healing   IMP   2290270 MGI:MGI:5284806|PMID:14617288 UniProtKB MGI:MGI:5284806 PMID:14617288 negative regulation of wound healing   IMP   2290270 MGI:MGI:1352043|PMID:10559937 UniProtKB MGI:MGI:1352043 PMID:10559937 negative regulation of wound healing   IMP   2290270 MGI:MGI:5285145|PMID:21035443 UniProtKB MGI:MGI:5285145 PMID:21035443 nodal signaling pathway   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 osteoblast development   IGI MGI:MGI:1316736 2290270 MGI:MGI:3056877|PMID:15150273 MGI MGI:MGI:3056877 PMID:15150273 osteoblast differentiation   IMP   2290270 MGI:MGI:3654245|PMID:11585338 UniProtKB MGI:MGI:3654245 PMID:11585338 paraxial mesoderm morphogenesis   IMP MGI:MGI:1857696 2290270 MGI:MGI:3039049|PMID:15084457 MGI MGI:MGI:3039049 PMID:15084457 pericardium development   IGI MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 positive regulation of alkaline phosphatase activity   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of bone mineralization   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of canonical Wnt receptor signaling pathway   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of catenin import into nucleus   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of cell migration   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of chondrocyte differentiation   IMP   2290270 MGI:MGI:5285145|PMID:21035443 UniProtKB MGI:MGI:5285145 PMID:21035443 positive regulation of epithelial to mesenchymal transition   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of focal adhesion assembly   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of gene expression involved in extracellular matrix organization   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of interleukin-1 beta production   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of positive chemotaxis   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of stress fiber assembly   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of transcription factor import into nucleus   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of transcription from RNA polymerase II promoter   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of transcription from RNA polymerase II promoter   IGI MGI:MGI:1314872|MGI:MGI:894293|MGI:MGI:108051|MGI:MGI:98727 2290270 MGI:MGI:3696537|PMID:17159989 MGI MGI:MGI:3696537 PMID:17159989 positive regulation of transcription from RNA polymerase II promoter   IDA   2290270 MGI:MGI:2675699|PMID:12943993 MGI MGI:MGI:2675699 PMID:12943993 positive regulation of transcription from RNA polymerase II promoter   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of transcription from RNA polymerase II promoter   IGI MGI:MGI:106658|MGI:MGI:1344313 2290270 MGI:MGI:3641341|PMID:16824956 MGI MGI:MGI:3641341 PMID:16824956 positive regulation of transcription from RNA polymerase II promoter   IDA   2290270 MGI:MGI:3690196|PMID:16619037 MGI MGI:MGI:3690196 PMID:16619037 positive regulation of transcription from RNA polymerase II promoter   IDA   2290270 MGI:MGI:3056877|PMID:15150273 MGI MGI:MGI:3056877 PMID:15150273 positive regulation of transcription from RNA polymerase II promoter   IGI MGI:MGI:1316736 2290270 MGI:MGI:3056877|PMID:15150273 MGI MGI:MGI:3056877 PMID:15150273 positive regulation of transcription, DNA-dependent   IDA   2290270 MGI:MGI:3513643|PMID:15282343 MGI MGI:MGI:3513643 PMID:15282343 positive regulation of transcription, DNA-dependent   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of transcription, DNA-dependent   IDA   2290270 MGI:MGI:3056014|PMID:15464984 MGI MGI:MGI:3056014 PMID:15464984 positive regulation of transforming growth factor beta3 production   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein stabilization   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of binding   IDA   2290270 MGI:MGI:3513643|PMID:15282343 MGI MGI:MGI:3513643 PMID:15282343 regulation of epithelial cell proliferation   IMP MGI:MGI:1857695 2290270 MGI:MGI:3617027|PMID:12845704 MGI MGI:MGI:3617027 PMID:12845704 regulation of immune response   IMP   2290270 MGI:MGI:1332876|PMID:10064594 UniProtKB MGI:MGI:1332876 PMID:10064594 regulation of striated muscle tissue development   IDA   2290270 MGI:MGI:2153314|PMID:11711431 MGI MGI:MGI:2153314 PMID:11711431 regulation of transcription, DNA-dependent   IEA InterPro:IPR013790|InterPro:IPR003619|InterPro:IPR013019|InterPro:IPR001132 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 regulation of transcription, DNA-dependent   IEA UniProtKB-KW:KW-0805 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 regulation of transforming growth factor beta receptor signaling pathway   IDA   2290270 MGI:MGI:2153314|PMID:11711431 MGI MGI:MGI:2153314 PMID:11711431 regulation of transforming growth factor beta receptor signaling pathway   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of transforming growth factor beta2 production   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 response to hypoxia   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 signal transduction involved in regulation of gene expression   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 skeletal system development   IGI MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 SMAD protein complex assembly   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 SMAD protein complex assembly   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 somitogenesis   IMP MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 T cell activation   IMP   2290270 MGI:MGI:1332876|PMID:10064594 UniProtKB MGI:MGI:1332876 PMID:10064594 thyroid gland development   IGI MGI:MGI:108051 2290270 MGI:MGI:3618021|PMID:15183723 MGI MGI:MGI:3618021 PMID:15183723 transcription from RNA polymerase II promoter   TAS   2290270 MGI:MGI:4441145|PMID:10823886 PINC MGI:MGI:4441145 PMID:10823886 transcription, DNA-dependent   IEA UniProtKB-KW:KW-0804 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 transdifferentiation   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 transforming growth factor beta receptor signaling pathway   IDA   2290270 MGI:MGI:3690196|PMID:16619037 MGI MGI:MGI:3690196 PMID:16619037 transforming growth factor beta receptor signaling pathway   IDA   2290270 MGI:MGI:5300220|PMID:21937600 MGI MGI:MGI:5300220 PMID:21937600 transforming growth factor beta receptor signaling pathway   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 transforming growth factor beta receptor signaling pathway   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 transport   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytoplasm   IDA   2290270 MGI:MGI:5009194|PMID:11160896 UniProtKB MGI:MGI:5009194 PMID:11160896 cytoplasm   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 cytoplasm   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 intracellular   IEA InterPro:IPR013790|InterPro:IPR003619|InterPro:IPR013019|InterPro:IPR001132 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 nuclear inner membrane   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 nucleus   IDA   2290270 MGI:MGI:2675699|PMID:12943993 MGI MGI:MGI:2675699 PMID:12943993 nucleus   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 nucleus   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 nucleus   IDA   2290270 MGI:MGI:5009194|PMID:11160896 UniProtKB MGI:MGI:5009194 PMID:11160896 nucleus   IDA   2290270 MGI:MGI:3513643|PMID:15282343 MGI MGI:MGI:3513643 PMID:15282343 plasma membrane   IDA   2290270 MGI:MGI:2449899|PMID:12543979 MGI MGI:MGI:2449899 PMID:12543979 protein complex   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 receptor complex   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 SMAD protein complex   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 transcription factor complex   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 transcription factor complex   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) beta-catenin binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 chromatin binding   IDA   2290270 MGI:MGI:3690196|PMID:16619037 MGI MGI:MGI:3690196 PMID:16619037 chromatin DNA binding   IDA   2290270 MGI:MGI:3696631|PMID:16224064 BHF-UCL MGI:MGI:3696631 PMID:16224064 co-SMAD binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 collagen binding   IPI UniProtKB:Q01149|UniProtKB:Q3U962|UniProtKB:P08121 2290270 MGI:MGI:2679769|PMID:14559231 MGI MGI:MGI:2679769 PMID:14559231 core promoter proximal region sequence-specific DNA binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 DNA binding   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 double-stranded DNA binding   IDA   2290270 MGI:MGI:3513643|PMID:15282343 MGI MGI:MGI:3513643 PMID:15282343 enzyme binding   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 metal ion binding   IEA UniProtKB-KW:KW-0479 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 phosphatase binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 protein binding   IPI UniProtKB:P10085 2290270 MGI:MGI:2153314|PMID:11711431 MGI MGI:MGI:2153314 PMID:11711431 protein binding   IPI UniProtKB:A7M7C7 2290270 MGI:MGI:5300220|PMID:21937600 MGI MGI:MGI:5300220 PMID:21937600 protein binding   IPI UniProtKB:Q15327 2290270 MGI:MGI:5294529|PMID:20599664 BHF-UCL MGI:MGI:5294529 PMID:20599664 protein binding   IPI UniProtKB:P20263 2290270 MGI:MGI:5315322|PMID:22036565 IntAct MGI:MGI:5315322 PMID:22036565 protein binding   IPI UniProtKB:O95551 2290270 MGI:MGI:3813431|PMID:18039968 UniProtKB MGI:MGI:3813431 PMID:18039968 protein binding   IPI UniProtKB:Q8VIM5 2290270 MGI:MGI:3696631|PMID:16224064 BHF-UCL MGI:MGI:3696631 PMID:16224064 protein binding   IPI UniProtKB:Q9DBX1 2290270 MGI:MGI:5317995|PMID:21990365 UniProtKB MGI:MGI:5317995 PMID:21990365 protein binding   IPI UniProtKB:Q6NZM9|UniProtKB:Q9Z2V6|UniProtKB:Q08775 2290270 MGI:MGI:3584056|PMID:15990875 MGI MGI:MGI:3584056 PMID:15990875 protein binding   IPI UniProtKB:O35625 2290270 MGI:MGI:3628833|PMID:16601693 MGI MGI:MGI:3628833 PMID:16601693 protein binding   IPI UniProtKB:Q6PGA9 2290270 MGI:MGI:3690196|PMID:16619037 MGI MGI:MGI:3690196 PMID:16619037 protein binding   IPI RefSeq:NP_081780 2290270 MGI:MGI:3715554|PMID:17467076 MGI MGI:MGI:3715554 PMID:17467076 protein binding   IPI UniProtKB:O88559 2290270 MGI:MGI:3056877|PMID:15150273 MGI MGI:MGI:3056877 PMID:15150273 protein binding   IPI UniProtKB:P42669|UniProtKB:O35295 2290270 MGI:MGI:3513643|PMID:15282343 MGI MGI:MGI:3513643 PMID:15282343 protein binding   IPI UniProtKB:Q61656 2290270 MGI:MGI:3056014|PMID:15464984 MGI MGI:MGI:3056014 PMID:15464984 protein binding   IPI UniProtKB:P70435 2290270 MGI:MGI:2449899|PMID:12543979 MGI MGI:MGI:2449899 PMID:12543979 protein homodimerization activity   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 protein kinase binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 R-SMAD binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 RNA polymerase II activating transcription factor binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 sequence-specific DNA binding   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 sequence-specific DNA binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 sequence-specific DNA binding transcription factor activity   IDA   2290270 MGI:MGI:2675699|PMID:12943993 MGI MGI:MGI:2675699 PMID:12943993 sequence-specific DNA binding transcription factor activity   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 sequence-specific DNA binding transcription factor activity   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 SMAD binding   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 transcription factor binding   IPI UniProtKB:B7ZQJ9 2290270 MGI:MGI:4399035|PMID:11937490 UniProtKB MGI:MGI:4399035 PMID:11937490 transcription factor binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 transcription factor binding   ISO UniProtKB:P84025 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 transcription regulatory region DNA binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 transforming growth factor beta receptor binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 ubiquitin binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 ubiquitin protein ligase binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 zinc ion binding   ISO UniProtKB:P84022 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) activin signaling pathway   ISS   1559169   RGD   altered transforming growth factor-beta Smad dependent signaling pathway   ISS RGD:1343311 2306282   RGD   altered transforming growth factor-beta Smad dependent signaling pathway   ISS RGD:1343311 5490966   RGD   cell cycle pathway, mitotic   IEA RGD:735647 6907045   KEGG mmu:04110 ceramide signaling pathway   IEA RGD:735647 6907045   KEGG mmu:05212 chronic myeloid leukemia pathway   IEA RGD:735647 6907045   KEGG mmu:05220 colorectal cancer pathway   ISS RGD:1343311 2306282   RGD   colorectal cancer pathway   IEA RGD:735647 6907045   KEGG mmu:05210 endocytosis pathway   IEA RGD:735647 6907045   KEGG mmu:04144 hypoxia inducible factor pathway   ISO RGD:1343311 6484113   PID PID:200202 pancreatic cancer pathway   ISS RGD:1343311 5490966   RGD   pancreatic cancer pathway   IEA RGD:735647 6907045   KEGG mmu:05212 transforming growth factor-beta Smad dependent signaling pathway   ISS RGD:3032 1599906   RGD   transforming growth factor-beta Smad dependent signaling pathway   ISO RGD:1343311 6484113   PID PID:200227 transforming growth factor-beta Smad dependent signaling pathway   ISS RGD:3032 1625706   RGD   transforming growth factor-beta superfamily mediated signaling pathway   IEA RGD:735647 6907045   KEGG mmu:04350 Trypanosoma cruzi infection pathway   IEA RGD:735647 6907045   KEGG mmu:05142 Wnt signaling pathway   IEA RGD:735647 6907045   KEGG mmu:04310 External Database Links KEGG Pathway Adherens junction Cell cycle Chagas disease (American trypanosomiasis) Chronic myeloid leukemia Colorectal cancer Endocytosis Hippo signaling pathway HTLV-I infection Pancreatic cancer Pathways in cancer TGF-beta signaling pathway Wnt signaling pathway Pathway Interaction Database HIF-1-alpha transcription factor network (PID:200202) Regulation of cytoplasmic and nuclear SMAD2/3 signaling (PID:200178) Regulation of nuclear SMAD2/3 signaling (PID:200003) Regulation of Telomerase (PID:200086) TGF-beta receptor signaling (PID:200227) Validated targets of C-MYC transcriptional activation (PID:200056) Validated targets of C-MYC transcriptional repression (PID:200200) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal anterior definitive endoderm morphology   IAGP   5509061   MGI PMID:20508035 abnormal articular cartilage morphology   IAGP   5509061   MGI PMID:11285272 abnormal B cell proliferation   IAGP   5509061   MGI PMID:10082515 abnormal carpal bone morphology   IAGP   5509061   MGI PMID:10082515 abnormal cartilage morphology   IAGP   5509061   MGI PMID:11285272 abnormal CD4-positive T cell differentiation   IAGP   5509061   MGI PMID:18474630 abnormal cell morphology   IAGP   5509061   MGI PMID:16382155 abnormal cell physiology   IAGP   5509061   MGI PMID:16382155 abnormal cell proliferation   IAGP   5509061   MGI PMID:10082515 abnormal chondrocyte morphology   IAGP   5509061   MGI PMID:11285272 abnormal circulating interleukin-6 level   IAGP   5509061   MGI PMID:21525133 abnormal colon morphology   IAGP   5509061   MGI PMID:20197623 abnormal craniofacial morphology   IAGP   5509061   MGI PMID:11438667 abnormal craniofacial morphology   IAGP   5509061   MGI PMID:15183723 abnormal cumulus expansion   IAGP   5509061   MGI PMID:18809571 abnormal cytokine secretion   IAGP   5509061   MGI PMID:21525133 abnormal cytokine secretion   IAGP   5509061   MGI PMID:10082515 abnormal developmental patterning   IAGP   5509061   MGI PMID:15183723 abnormal embryonic tissue morphology   IAGP   5509061   MGI PMID:20508035 abnormal endoderm development   IAGP   5509061   MGI PMID:15183723 abnormal epiphyseal plate morphology   IAGP   5509061   MGI PMID:11285272 abnormal fertility/fecundity   IAGP   5509061   MGI PMID:9753318 abnormal foregut morphology   IAGP   5509061   MGI PMID:12842913 abnormal foregut morphology   IAGP   5509061   MGI PMID:15183723 abnormal forelimb morphology   IAGP   5509061   MGI PMID:11285272 abnormal gastrulation   IAGP   5509061   MGI PMID:15183723 abnormal heart development   IAGP   5509061   MGI PMID:12842913 abnormal heart looping   IAGP   5509061   MGI PMID:15183723 abnormal hepatocyte morphology   IAGP   5509061   MGI PMID:11438667 abnormal immune system morphology   IAGP   5509061   MGI PMID:10064594 abnormal joint capsule morphology   IAGP   5509061   MGI PMID:11285272 abnormal joint morphology   IAGP   5509061   MGI PMID:11285272 abnormal keratinocyte physiology   IAGP   5509061   MGI PMID:10559937 abnormal kidney epithelium morphology   IAGP   5509061   MGI PMID:14617750 abnormal leukocyte physiology   IAGP   5509061   MGI PMID:10559937 abnormal liver development   IAGP   5509061   MGI PMID:15183723 abnormal liver morphology   IAGP   5509061   MGI PMID:11438667 abnormal locomotor behavior   IAGP   5509061   MGI PMID:11285272 abnormal Meckel's cartilage morphology   IAGP   5509061   MGI PMID:11984875 abnormal mesangial matrix morphology   IAGP   5509061   MGI PMID:17804483 abnormal mesendoderm development   IAGP   5509061   MGI PMID:20508035 abnormal ovarian follicle morphology   IAGP   5509061   MGI PMID:18809571 abnormal ovarian folliculogenesis   IAGP   5509061   MGI PMID:17652186 abnormal pericardium morphology   IAGP   5509061   MGI PMID:15183723 abnormal physiological response to xenobiotic   IAGP   5509061   MGI PMID:18434384 abnormal physiological response to xenobiotic   IAGP   5509061   MGI PMID:17804483 abnormal posture   IAGP   5509061   MGI PMID:9753318 abnormal prechordal plate morphology   IAGP   5509061   MGI PMID:20508035 abnormal primitive streak formation   IAGP   5509061   MGI PMID:20508035 abnormal rectum morphology   IAGP   5509061   MGI PMID:20197623 abnormal renal glomerulus basement membrane thickness   IAGP   5509061   MGI PMID:17804483 abnormal rib morphology   IAGP   5509061   MGI PMID:10082515 abnormal rib morphology   IAGP   5509061   MGI PMID:11285272 abnormal rostral-caudal axis patterning   IAGP   5509061   MGI PMID:12842913 abnormal secondary ovarian follicle morphology   IAGP   5509061   MGI PMID:18809571 abnormal Sertoli cell morphology   IAGP   5509061   MGI PMID:17652186 abnormal skeleton physiology   IAGP   5509061   MGI PMID:11285272 abnormal somite development   IAGP   5509061   MGI PMID:12842913 abnormal somite development   IAGP   5509061   MGI PMID:15183723 abnormal sternum morphology   IAGP   5509061   MGI PMID:10082515 abnormal T cell activation   IAGP   5509061   MGI PMID:10064594 abnormal T cell physiology   IAGP   5509061   MGI PMID:10064594 abnormal T cell proliferation   IAGP   5509061   MGI PMID:10082515 abnormal talus morphology   IAGP   5509061   MGI PMID:10082515 abnormal tarsal bone morphology   IAGP   5509061   MGI PMID:11285272 abnormal thoracic cage morphology   IAGP   5509061   MGI PMID:10082515 abnormal thymus involution   IAGP   5509061   MGI PMID:10064594 abnormal vascular wound healing   IAGP   5509061   MGI PMID:15790953 calcified joint   IAGP   5509061   MGI PMID:11285272 colitis   IAGP   5509061   MGI PMID:10064594 colon adenocarcinoma   IAGP   5509061   MGI PMID:20197623 colon polyps   IAGP   5509061   MGI PMID:20197623 complete lethality throughout fetal growth and development   IAGP   5509061   MGI PMID:15183723 cyclopia   IAGP   5509061   MGI PMID:15183723 decreased apoptosis   IAGP   5509061   MGI PMID:16382155 decreased B cell apoptosis   IAGP   5509061   MGI PMID:18704116 decreased blood urea nitrogen level   IAGP   5509061   MGI PMID:21525133 decreased blood urea nitrogen level   IAGP   5509061   MGI PMID:17804483 decreased body size   IAGP   5509061   MGI PMID:10064594 decreased body size   IAGP   5509061   MGI PMID:10082515 decreased body size   IAGP   5509061   MGI PMID:9753318 decreased bone mineral density   IAGP   5509061   MGI PMID:11285272 decreased circulating creatinine level   IAGP   5509061   MGI PMID:21525133 decreased circulating creatinine level   IAGP   5509061   MGI PMID:17804483 decreased hepatocyte proliferation   IAGP   5509061   MGI PMID:11438667 decreased interleukin-6 secretion   IAGP   5509061   MGI PMID:21525133 decreased kidney weight   IAGP   5509061   MGI PMID:17804483 decreased litter size   IAGP   5509061   MGI PMID:18809571 decreased oocyte number   IAGP   5509061   MGI PMID:18809571 decreased renal tubule apoptosis   IAGP   5509061   MGI PMID:15253712 decreased susceptibility to injury   IAGP   5509061   MGI PMID:14617750 decreased susceptibility to injury   IAGP   5509061   MGI PMID:15253712 decreased susceptibility to kidney reperfusion injury   IAGP   5509061   MGI PMID:21525133 distended abdomen   IAGP   5509061   MGI PMID:9753318 embryonic growth retardation   IAGP   5509061   MGI PMID:15183723 enhanced wound healing   IAGP   5509061   MGI PMID:10559937 enlarged liver sinusoidal spaces   IAGP   5509061   MGI PMID:11438667 enlarged lymph nodes   IAGP   5509061   MGI PMID:10064594 enlarged mesenteric lymph nodes   IAGP   5509061   MGI PMID:10064594 extramedullary hematopoiesis   IAGP   5509061   MGI PMID:10064594 holoprosencephaly   IAGP   5509061   MGI PMID:15183723 holoprosencephaly   IAGP   5509061   MGI PMID:20508035 impaired neutrophil chemotaxis   IAGP   5509061   MGI PMID:10064594 increased adenoma incidence   IAGP   5509061   MGI PMID:16041381 increased adrenal gland tumor incidence   IAGP   5509061   MGI PMID:17652186 increased body weight   IAGP   5509061   MGI PMID:17804483 increased circulating creatinine level   IAGP   5509061   MGI PMID:18434384 increased circulating follicle stimulating hormone level   IAGP   5509061   MGI PMID:18809571 increased circulating luteinizing hormone level   IAGP   5509061   MGI PMID:18809571 increased erythrocyte cell number   IAGP   5509061   MGI PMID:11438667 increased fetal size   IAGP   5509061   MGI PMID:11438667 increased inflammatory response   IAGP   5509061   MGI PMID:10064594 increased inflammatory response   IAGP   5509061   MGI PMID:16424015 increased leukocyte cell number   IAGP   5509061   MGI PMID:10064594 increased metastatic potential   IAGP   5509061   MGI PMID:9753318 increased monocyte cell number   IAGP   5509061   MGI PMID:10064594 increased neutrophil cell number   IAGP   5509061   MGI PMID:10064594 increased ovary tumor incidence   IAGP   5509061   MGI PMID:17652186 increased physiological sensitivity to xenobiotic   IAGP   5509061   MGI PMID:16382155 increased susceptibility to kidney reperfusion injury   IAGP   5509061   MGI PMID:18434384 increased width of hypertrophic chondrocyte zone   IAGP   5509061   MGI PMID:11285272 intestinal adenocarcinoma   IAGP   5509061   MGI PMID:10064594 intestinal adenocarcinoma   IAGP   5509061   MGI PMID:16424015 intestinal adenocarcinoma   IAGP   5509061   MGI PMID:9753318 intestinal obstruction   IAGP   5509061   MGI PMID:9753318 kyphoscoliosis   IAGP   5509061   MGI PMID:11285272 kyphosis   IAGP   5509061   MGI PMID:10064594 kyphosis   IAGP   5509061   MGI PMID:11285272 kyphosis   IAGP   5509061   MGI PMID:10082515 large intestinal inflammation   IAGP   5509061   MGI PMID:10064594 lethargy   IAGP   5509061   MGI PMID:9753318 liver hypoplasia   IAGP   5509061   MGI PMID:11438667 liver hypoplasia   IAGP   5509061   MGI PMID:15183723 osteoarthritis   IAGP   5509061   MGI PMID:15630024 osteoarthritis   IAGP   5509061   MGI PMID:11285272 pancreas inflammation   IAGP   5509061   MGI PMID:10064594 partial embryonic lethality during organogenesis   IAGP   5509061   MGI PMID:11438667 premature death   IAGP   5509061   MGI PMID:10064594 premature death   IAGP   5509061   MGI PMID:16382155 premature death   IAGP   5509061   MGI PMID:9753318 rectal prolapse   IAGP   5509061   MGI PMID:9753318 reduced female fertility   IAGP   5509061   MGI PMID:18809571 renal interstitial fibrosis   IAGP   5509061   MGI PMID:15253712 renal tubular necrosis   IAGP   5509061   MGI PMID:18434384 ruffled hair   IAGP   5509061   MGI PMID:9753318 small intestinal inflammation   IAGP   5509061   MGI PMID:10064594 small liver   IAGP   5509061   MGI PMID:11438667 small spleen   IAGP   5509061   MGI PMID:10064594 small thyroid gland   IAGP   5509061   MGI PMID:15183723 spleen hypoplasia   IAGP   5509061   MGI PMID:10064594 stomach inflammation   IAGP   5509061   MGI PMID:10064594 thymus hypoplasia   IAGP   5509061   MGI PMID:10064594 tubulointerstitial nephritis   IAGP   5509061   MGI PMID:15253712 Disease Annotations Colorectal Neoplasms  (ISS) Colorectal Neoplasms, Hereditary Nonpolyposis  (ISS) Endometrial Neoplasms  (ISS) Prostatic Neoplasms  (ISS) Gene-Chemical Interaction Annotations (-)-epigallocatechin 3-gallate  (ISO) (S)-nicotine  (EXP) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP) 17alpha-ethynylestradiol  (EXP) 17beta-estradiol  (ISO) 17beta-hydroxy-5alpha-androstan-3-one  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (EXP) 2-acetamidofluorene  (ISO) 3,4-dihydroxybenzaldehyde  (ISO) 3,4-methylenedioxymethamphetamine  (EXP) 4-vinylcyclohexene dioxide  (EXP) 9-cis-retinoic acid  (EXP) acetaldehyde  (ISO) aflatoxin B1  (ISO) all-trans-retinoic acid  (EXP,ISO) benazepril  (ISO) benzo[a]pyrene  (EXP,ISO) benzo[b]fluoranthene  (ISO) betulin  (ISO) betulinic acid  (ISO) bis(2-chloroethyl) sulfide  (EXP) caffeine  (EXP) candesartan  (ISO) CGS-21680  (ISO) cholesterol  (EXP) choline  (EXP) cisplatin  (ISO) copper(2+) sulfate  (ISO) coumestrol  (ISO) curcumin  (ISO) D-glucose  (ISO) dexamethasone  (EXP) diarsenic trioxide  (ISO) dibenz[a,h]anthracene  (ISO) dibenzo[a,l]pyrene  (ISO) dibutyl phthalate  (EXP) disodium selenite  (ISO) doxorubicin  (ISO) ethanol  (ISO) fenofibrate  (ISO) fluoranthene  (ISO) folic acid  (EXP) glucose  (ISO) hydrogen peroxide  (EXP,ISO) irbesartan  (ISO) L-methionine  (EXP) lycopene  (ISO) melphalan  (ISO) menadione  (ISO) methylmercury chloride  (EXP) N-nitrosodiethylamine  (ISO) nitric oxide  (ISO) paracetamol  (EXP,ISO) paraquat  (EXP) perindopril  (ISO) pirinixic acid  (EXP) resveratrol  (EXP,ISO) rosiglitazone  (ISO) sevoflurane  (EXP) silver(1+) nitrate  (ISO) simvastatin  (EXP,ISO) streptozocin  (ISO) tamoxifen  (ISO) testosterone  (EXP) tetrachloromethane  (EXP,ISO) trans-resveratrol  (EXP,ISO) troglitazone  (ISO) ursodeoxycholic acid  (ISO) valsartan  (ISO) zinc atom  (EXP) zinc(0)  (EXP) Gene Ontology Annotations Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO) activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO) activin receptor signaling pathway  (ISO) cell cycle arrest  (ISO) cell-cell junction organization  (ISO) developmental growth  (IGI) embryonic cranial skeleton morphogenesis  (IGI) embryonic foregut morphogenesis  (IGI) embryonic pattern specification  (IGI) endoderm development  (IGI) evasion or tolerance of host defenses by virus  (ISO) gastrulation  (IGI) heart looping  (IGI) immune response  (ISO) immune system development  (IGI) in utero embryonic development  (IGI) induction of apoptosis  (ISO) lens fiber cell differentiation  (IMP) liver development  (IGI) mesoderm formation  (IMP) negative regulation of apoptotic process  (ISO) negative regulation of cell growth  (ISO) negative regulation of cell proliferation  (ISO) negative regulation of inflammatory response  (IMP) negative regulation of mitotic cell cycle  (ISO) negative regulation of osteoblast differentiation  (IGI) negative regulation of osteoblast proliferation  (IMP) negative regulation of protein catabolic process  (ISO) negative regulation of protein phosphorylation  (ISO) negative regulation of transcription from RNA polymerase II promoter  (IDA,ISO) negative regulation of wound healing  (IMP) nodal signaling pathway  (ISO) osteoblast development  (IGI) osteoblast differentiation  (IMP) paraxial mesoderm morphogenesis  (IMP) pericardium development  (IGI) positive regulation of alkaline phosphatase activity  (ISO) positive regulation of bone mineralization  (ISO) positive regulation of canonical Wnt receptor signaling pathway  (ISO) positive regulation of catenin import into nucleus  (ISO) positive regulation of cell migration  (ISO) positive regulation of chondrocyte differentiation  (IMP) positive regulation of epithelial to mesenchymal transition  (ISO) positive regulation of focal adhesion assembly  (ISO) positive regulation of gene expression involved in extracellular matrix organization  (ISO) positive regulation of interleukin-1 beta production  (ISO) positive regulation of positive chemotaxis  (ISO) positive regulation of stress fiber assembly  (ISO) positive regulation of transcription factor import into nucleus  (ISO) positive regulation of transcription from RNA polymerase II promoter  (IDA,IGI,ISO) positive regulation of transcription, DNA-dependent  (IDA,ISO) positive regulation of transforming growth factor beta3 production  (ISO) protein stabilization  (ISO) regulation of binding  (IDA) regulation of epithelial cell proliferation  (IMP) regulation of immune response  (IMP) regulation of striated muscle tissue development  (IDA) regulation of transcription, DNA-dependent  (IEA) regulation of transforming growth factor beta receptor signaling pathway  (IDA,ISO) regulation of transforming growth factor beta2 production  (ISO) response to hypoxia  (ISO) signal transduction involved in regulation of gene expression  (ISO) skeletal system development  (IGI) SMAD protein complex assembly  (ISO) somitogenesis  (IMP) T cell activation  (IMP) thyroid gland development  (IGI) transcription from RNA polymerase II promoter  (TAS) transcription, DNA-dependent  (IEA) transdifferentiation  (ISO) transforming growth factor beta receptor signaling pathway  (IDA,ISO) transport  (ISO) Cellular Component cytoplasm  (IDA,ISO) intracellular  (IEA) nuclear inner membrane  (ISO) nucleus  (IDA,ISO) plasma membrane  (IDA) protein complex  (ISO) receptor complex  (ISO) SMAD protein complex  (ISO) transcription factor complex  (ISO) Molecular Function beta-catenin binding  (ISO) chromatin binding  (IDA) chromatin DNA binding  (IDA) co-SMAD binding  (ISO) collagen binding  (IPI) core promoter proximal region sequence-specific DNA binding  (ISO) DNA binding  (ISO) double-stranded DNA binding  (IDA) enzyme binding  (ISO) metal ion binding  (IEA) phosphatase binding  (ISO) protein binding  (IPI) protein homodimerization activity  (ISO) protein kinase binding  (ISO) R-SMAD binding  (ISO) RNA polymerase II activating transcription factor binding  (ISO) sequence-specific DNA binding  (ISO) sequence-specific DNA binding transcription factor activity  (IDA,ISO) SMAD binding  (ISO) transcription factor binding  (IPI,ISO) transcription regulatory region DNA binding  (ISO) transforming growth factor beta receptor binding  (ISO) transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity  (ISO) ubiquitin binding  (ISO) ubiquitin protein ligase binding  (ISO) zinc ion binding  (ISO) Molecular Pathway Annotations activin signaling pathway  (ISS) altered transforming growth factor-beta Smad dependent signaling pathway  (ISS) cell cycle pathway, mitotic  (IEA) ceramide signaling pathway  (IEA) chronic myeloid leukemia pathway  (IEA) colorectal cancer pathway  (IEA,ISS) endocytosis pathway  (IEA) hypoxia inducible factor pathway  (ISO) pancreatic cancer pathway  (IEA,ISS) transforming growth factor-beta Smad dependent signaling pathway  (ISO,ISS) transforming growth factor-beta superfamily mediated signaling pathway  (IEA) Trypanosoma cruzi infection pathway  (IEA) Wnt signaling pathway  (IEA) External Database Links KEGG Pathway Adherens junction Cell cycle Chagas disease (American trypanosomiasis) Chronic myeloid leukemia Colorectal cancer Endocytosis Hippo signaling pathway HTLV-I infection Pancreatic cancer Pathways in cancer TGF-beta signaling pathway Wnt signaling pathway Pathway Interaction Database HIF-1-alpha transcription factor network (PID:200202) Regulation of cytoplasmic and nuclear SMAD2/3 signaling (PID:200178) Regulation of nuclear SMAD2/3 signaling (PID:200003) Regulation of Telomerase (PID:200086) TGF-beta receptor signaling (PID:200227) Validated targets of C-MYC transcriptional activation (PID:200056) Validated targets of C-MYC transcriptional repression (PID:200200) Phenotype Annotations abnormal anterior definitive endoderm morphology  (IAGP) abnormal articular cartilage morphology  (IAGP) abnormal B cell proliferation  (IAGP) abnormal carpal bone morphology  (IAGP) abnormal cartilage morphology  (IAGP) abnormal CD4-positive T cell differentiation  (IAGP) abnormal cell morphology  (IAGP) abnormal cell physiology  (IAGP) abnormal cell proliferation  (IAGP) abnormal chondrocyte morphology  (IAGP) abnormal circulating interleukin-6 level  (IAGP) abnormal colon morphology  (IAGP) abnormal craniofacial morphology  (IAGP) abnormal cumulus expansion  (IAGP) abnormal cytokine secretion  (IAGP) abnormal developmental patterning  (IAGP) abnormal embryonic tissue morphology  (IAGP) abnormal endoderm development  (IAGP) abnormal epiphyseal plate morphology  (IAGP) abnormal fertility/fecundity  (IAGP) abnormal foregut morphology  (IAGP) abnormal forelimb morphology  (IAGP) abnormal gastrulation  (IAGP) abnormal heart development  (IAGP) abnormal heart looping  (IAGP) abnormal hepatocyte morphology  (IAGP) abnormal immune system morphology  (IAGP) abnormal joint capsule morphology  (IAGP) abnormal joint morphology  (IAGP) abnormal keratinocyte physiology  (IAGP) abnormal kidney epithelium morphology  (IAGP) abnormal leukocyte physiology  (IAGP) abnormal liver development  (IAGP) abnormal liver morphology  (IAGP) abnormal locomotor behavior  (IAGP) abnormal Meckel's cartilage morphology  (IAGP) abnormal mesangial matrix morphology  (IAGP) abnormal mesendoderm development  (IAGP) abnormal ovarian follicle morphology  (IAGP) abnormal ovarian folliculogenesis  (IAGP) abnormal pericardium morphology  (IAGP) abnormal physiological response to xenobiotic  (IAGP) abnormal posture  (IAGP) abnormal prechordal plate morphology  (IAGP) abnormal primitive streak formation  (IAGP) abnormal rectum morphology  (IAGP) abnormal renal glomerulus basement membrane thickness  (IAGP) abnormal rib morphology  (IAGP) abnormal rostral-caudal axis patterning  (IAGP) abnormal secondary ovarian follicle morphology  (IAGP) abnormal Sertoli cell morphology  (IAGP) abnormal skeleton physiology  (IAGP) abnormal somite development  (IAGP) abnormal sternum morphology  (IAGP) abnormal T cell activation  (IAGP) abnormal T cell physiology  (IAGP) abnormal T cell proliferation  (IAGP) abnormal talus morphology  (IAGP) abnormal tarsal bone morphology  (IAGP) abnormal thoracic cage morphology  (IAGP) abnormal thymus involution  (IAGP) abnormal vascular wound healing  (IAGP) calcified joint  (IAGP) colitis  (IAGP) colon adenocarcinoma  (IAGP) colon polyps  (IAGP) complete lethality throughout fetal growth and development  (IAGP) cyclopia  (IAGP) decreased apoptosis  (IAGP) decreased B cell apoptosis  (IAGP) decreased blood urea nitrogen level  (IAGP) decreased body size  (IAGP) decreased bone mineral density  (IAGP) decreased circulating creatinine level  (IAGP) decreased hepatocyte proliferation  (IAGP) decreased interleukin-6 secretion  (IAGP) decreased kidney weight  (IAGP) decreased litter size  (IAGP) decreased oocyte number  (IAGP) decreased renal tubule apoptosis  (IAGP) decreased susceptibility to injury  (IAGP) decreased susceptibility to kidney reperfusion injury  (IAGP) distended abdomen  (IAGP) embryonic growth retardation  (IAGP) enhanced wound healing  (IAGP) enlarged liver sinusoidal spaces  (IAGP) enlarged lymph nodes  (IAGP) enlarged mesenteric lymph nodes  (IAGP) extramedullary hematopoiesis  (IAGP) holoprosencephaly  (IAGP) impaired neutrophil chemotaxis  (IAGP) increased adenoma incidence  (IAGP) increased adrenal gland tumor incidence  (IAGP) increased body weight  (IAGP) increased circulating creatinine level  (IAGP) increased circulating follicle stimulating hormone level  (IAGP) increased circulating luteinizing hormone level  (IAGP) increased erythrocyte cell number  (IAGP) increased fetal size  (IAGP) increased inflammatory response  (IAGP) increased leukocyte cell number  (IAGP) increased metastatic potential  (IAGP) increased monocyte cell number  (IAGP) increased neutrophil cell number  (IAGP) increased ovary tumor incidence  (IAGP) increased physiological sensitivity to xenobiotic  (IAGP) increased susceptibility to kidney reperfusion injury  (IAGP) increased width of hypertrophic chondrocyte zone  (IAGP) intestinal adenocarcinoma  (IAGP) intestinal obstruction  (IAGP) kyphoscoliosis  (IAGP) kyphosis  (IAGP) large intestinal inflammation  (IAGP) lethargy  (IAGP) liver hypoplasia  (IAGP) osteoarthritis  (IAGP) pancreas inflammation  (IAGP) partial embryonic lethality during organogenesis  (IAGP) premature death  (IAGP) rectal prolapse  (IAGP) reduced female fertility  (IAGP) renal interstitial fibrosis  (IAGP) renal tubular necrosis  (IAGP) ruffled hair  (IAGP) small intestinal inflammation  (IAGP) small liver  (IAGP) small spleen  (IAGP) small thyroid gland  (IAGP) spleen hypoplasia  (IAGP) stomach inflammation  (IAGP) thymus hypoplasia  (IAGP) tubulointerstitial nephritis  (IAGP) References - curated 1. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7. 2. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4. 3. Ko MS, etal., Development 2000 Apr;127(8):1737-49. 4. Liu G, etal., J Biol Chem. 2006 Oct 6;281(40):29479-90. Epub 2006 Aug 4. 5. Liu X, etal., Mol Pharmacol. 2006 Dec;70(6):1992-2003. Epub 2006 Sep 7. 6. Lu S, etal., Clin Cancer Res. 2007 Oct 1;13(19):5692-702. 7. MGD and Homologene mouse data transfer 8. MGD data from the GO Consortium 9. MGD IEA 10. Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. 11. Piestrzeniewicz-Ulanska D, etal., Oncol Rep. 2003 Sep-Oct;10(5):1539-44. 12. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 13. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 14. RGD automated import pipeline 15. RGD automated import pipeline for gene-chemical interactions 16. Roth S, etal., J Med Genet. 2000 Apr;37(4):298-300. 17. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20. References - uncurated PubMed 10064594   10082515   10224044   10331191   10341708   10349636   10376010   10511616   10559937   10647776   10681527   10708948   10708949   10708952   10708960   10823886   10862745   10922068   11042159   11076861   11094085   11106407   11160896   11169847   11217851   11226283   11231077   11285272   11404094   11418665   11431738   11438667   11585338   11711431   11839555   11850197   11891202   11906909   11937490   11959813   11984875   12069494   12086850   12119348   12130649   12145309   12426318   12477932   12524424   12543979   12637528   12650946   12672795   12763048   12767930   12782414   12814934   12815042   12839562   12839923   12842913   12845704   12880367   12943993   14502566   14517210   14559231   14580334   14610273   14617288   14617750   14633599   14635047   14636827   14651998   14656760   14662776   14701940   14742269   14752027   14764653   14963116   15004187   15034041   15047135   15059931   15063768   15084457   15133179   15150273   15183723   15192076   15195967   15215176   15225210   15225218   15241418   15247277   15253712   15254903   15260977   15265946   15273699   15277382   15282343   15292219   15295048   15356151   15464984   15470497   15489334   15496141   15520189   15521071   15566516   15591413   15618518   15629128   15629866   15630024   15699137   15708854   15728487   15730859   15761153   15778380   15782199   15790953   15800576   15845540   15963767   15969059   15972691   15986223   15990875   16007227   16018191   16021625   16041381   16141072   16141073   16210645   16224064   16227596   16290023   16317010   16354202   16354837   16355269   16382155   16403009   16423881   16424015   16435884   16477644   16484320   16581977   16601693   16602821   16619037   16672340   16690606   16754864   16766264   16790475   16796722   16807527   16824956   16839529   16890162   16919269   16943282   16951153   16959237   16996058   17013388   17015622   17053163   17074756   17074765   17091762   17098824   17111301   17142805   17159989   17168649   17192514   17215516   17226765   17264540   17314307   17389684   17426249   17429065   17429443   17460146   17467076   17485510   17513781   17585069   17592132   17595316   17606870   17624738   17628518   17638910   17641300   17652186   17657819   17670744   17682064   17690314   17707214   17804483   17804598   17920684   17936489   17951260   17952112   17967775   17991884   18005957   18024957   18039968   18071588   18078810   18079204   18089935   18095342   18157133   18172167   18184649   18184786   18210139   18245174   18263591   18268325   18276785   18287559   18296617   18321991   18329379   18335503   18353861   18353867   18395096   18434384   18453534   18462697   18474630   18497983   18502822   18506886   18516051   18552838   18602626   18653563   18704116   18711354   18725385   18768831   18772333   18799693   18802055   18809571   18821706   18922473   18942075   18950738   18952608   19058853   19088845   19106105   19119184   19172185   19200168   19218245   19265200   19344627   19357234   19375497   19388084   19401440   19422482   19448624   19473993   19478656   19479035   19488034   19498055   19505891   19517569   19535790   19553668   19580641   19587446   19597490   19609088   19646988   19671686   19679673   19701891   19737861   19752570   19757385   19822523   19837676   19841536   19887374   19917253   19919989   19956083   19959709   20019329   20059953   20060825   20071455   20082218   20089076   20089673   20147383   20147459   20155334   20177825   20179325   20197623   20200042   20211142   20231525   20304828   20308569   20346939   20360068   20382892   20404343   20412781   20463050   20488955   20508035   20522804   20548029   20581097   20595680   20599664   20607716   20682692   20709799   20798218   20842701   20870174   20935647   21035443   21041365   21119112   21145499   21229365   21252157   21267068   21270259   21276420   21295571   21297643   21305609   21356196   21362339   21385936   21402709   21466802   21496353   21502976   21514423   21525133   21533152   21538804   21555266   21600798   21612856   21664424   21723505   21732483   21743024   21780244   21784902   21792478   21798735   21852586   21856951   21868450   21937600   21939397   21990365   21995845   22036565   22045334   22048127   22200784   22219364   22237801   22291941   22294749   22331441   22378822   22382019   22411066   22418736   22427664   22437318   22438570   22438993   22498737   22503540   22534961   22535746   22542937   22544933   22560297   22574112   22581813   22610349   22613712   22644778   22674505   22710166   22711699   22767605   22778267   22782721   22878587   22899851   22908322   22918885   22927430   22995554   23022526   23034213   23041440   23045614   23056222   8774881   9501027   9702197   9753318   9759503   9858566 RGD Disease Portals Smad3 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Cancer Phenotypes Biological Process Cardiovascular Pathways Cardiovascular Phenotypes Diabetes Diseases Diabetes Pathways Diabetes Phenotypes Biological Process Immune and Inflammatory Pathways Immune and Inflammatory Phenotypes Neurological Pathways Neurological Phenotypes Obesity Diseases Obesity Pathways Obesity Phenotypes Biological Process Respiratory Pathways Genomics Comparative Map Data Smad3   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 9 63,646,767 - 63,757,994 - NCBI Mouse cM Map 9   - NCBI Mouse Celera Assembly 9 60,869,117 - 60,980,879 - NCBI Mouse Genome Assembly Build 37 9 63,494,574 - 63,605,801 - NCBI Mouse Genome Assembly Build 36.1 9 63,494,574 - 63,605,801 - NCBI Mouse Cytogenetic Map 9 D   NCBI SMAD3   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 15 47,414,994 - 47,543,560 + NCBI Human Genome Assembly HuRef 15 44,193,465 - 44,321,904 + NCBI Human Genome Assembly GRCh37 15 67,358,195 - 67,487,533 + NCBI Human Genome Assembly Build 36 15 65,145,249 - 65,274,587 + NCBI Human Cytogenetic Map 15 q22.33   NCBI Human Genome Assembly 15 65,145,248 - 65,274,586   NCBI Smad3   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 8 q24   NCBI RGSC Genome Assembly v5.0 8 68,274,132 - 68,397,727 - NCBI RGSC Genome Assembly v3.4 8 67,803,909 - 67,952,056 - NCBI Rat Celera Assembly 8 63,520,702 - 63,647,062 - NCBI Genome Assembly 3.1 8 67,822,964 - 67,971,110 - NCBI Position Markers Smad3   Map Chr Position Strand Source Mouse Cytogenetic Map 9 D   UniSTS AU022421   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 9 63,646,923 - 63,647,074   UniSTS Mouse Whitehead/MRC_RH 9 632.25   UniSTS Mouse Celera Assembly 9 60,869,273 - 60,869,424   UniSTS Mouse Genome Assembly Build 37 9 63,494,730 - 63,494,881   UniSTS Mouse Cytogenetic Map 9 D   UniSTS RH138729   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 9 63,646,814 - 63,646,950   UniSTS Mouse Celera Assembly 9 60,869,164 - 60,869,300   UniSTS Mouse Genome Assembly Build 37 9 63,494,621 - 63,494,757   UniSTS Mouse Cytogenetic Map 9 D   UniSTS Madh3   Map Chr Position Strand Source Mouse cM Map UN     UniSTS Mouse Cytogenetic Map 9 D   UniSTS Madh3   Map Chr Position Strand Source Mouse cM Map UN     UniSTS Mouse Cytogenetic Map 9 D   UniSTS Madh3   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 9 63,667,786 - 63,667,916   UniSTS Mouse cM Map UN     UniSTS Mouse Celera Assembly 9 60,890,136 - 60,890,266   UniSTS Mouse Genome Assembly Build 37 9 63,515,593 - 63,515,723   UniSTS Mouse Cytogenetic Map 9 D   UniSTS Madh3   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 9 63,757,484 - 63,757,678   UniSTS Mouse cM Map UN     UniSTS Mouse cM Map 9     UniSTS Mouse Celera Assembly 9 60,980,370 - 60,980,564   UniSTS Mouse Genome Assembly Build 37 9 63,605,291 - 63,605,485   UniSTS Mouse Cytogenetic Map 9 D   UniSTS Mouse Cytogenetic Map 9 C   UniSTS Madh3   Map Chr Position Strand Source Mouse cM Map UN     UniSTS Mouse cM Map 9     UniSTS Mouse Cytogenetic Map 9 D   UniSTS Smad3   Map Chr Position Strand Source Mouse Cytogenetic Map 9 D   UniSTS QTLs in Region (Mouse Genome Assembly Build 37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1301365 Ap5q_m alcohol preference 5 QTL (mouse) Not determined 9 29949949 63950062 Mouse 4141260 Actre6_m activity response to ethanol 6 (mouse) Not determined 9 30439809 64439925 Mouse 1357746 Vtbt7_m vertebral trabecular bone trait 7 (mouse) Not determined 9 30636700 64636806 Mouse 4140969 Chcmq2_m mean cell hemoglobin concentration QTL 2 (mouse) Not determined 9 32313165 66313512 Mouse 1357768 Baa1_m BALB/c autoimmunity 1 (mouse) Not determined 9 32317103 66317316 Mouse 1302180 Actd4_m activity-distance traveled 4 (mouse) Not determined 9 32331368 66331662 Mouse 4141148 Cq5_m cholesterol QTL 5 (mouse) Not determined 9 32349226 66349351 Mouse 1301782 Chol11_m cholesterol 11 (mouse) Not determined 9 32349226 66349351 Mouse 1301692 Hts_m hypothermia sensitivity (mouse) Not determined 9 32407977 66408226 Mouse 4141323 Ptnu3_m proteinuria 3 (mouse) Not determined 9 32786507 66786641 Mouse 1357709 Si5lq3_m serum IGFBP-5 level QTL 3 (mouse) Not determined 9 33007830 67007945 Mouse 1301651 Tlf2_m T lymphocyte fraction 2 (mouse) Not determined 9 33007830 67007945 Mouse 4141078 Alpq1_m alcohol preference QTL 1 (mouse) Not determined 9 34931283 68931404 Mouse 1301972 Cocrb8_m cocaine related behavior 8 (mouse) Not determined 9 34931283 68931404 Mouse 1558968 Tbdr1_m body temperature response to dietary restriction, QTL 1 (mouse) Not determined 9 34931283 68931404 Mouse 1301252 Etohc3_m ethanol consumption 3 (mouse) Not determined 9 34931283 68931404 Mouse 4142042 Alpq3_m alcohol preference QTL 3 (mouse) Not determined 9 37202486 98720073 Mouse 1558872 Ibdq1_m inflammatory bowel disease QTL 1 (mouse) Not determined 9 40745571 74745728 Mouse 1357858 Ssta7_m susceptibility to Salmonella typhimurium antigens 7 (mouse) Not determined 9 41210366 75210495 Mouse 1300836 Cafq3_m caffeine metabolism QTL 3 (mouse) Not determined 9 41210366 75210495 Mouse 1559020 Mmtp3_m modifier of mammary tumor progression 3 (mouse) Not determined 9 43421238 77421384 Mouse 1301558 Stheal8_m soft tissue heal 8 (mouse) Not determined 9 43421238 77421384 Mouse 1301464 Lgth5_m body length 5 (mouse) Not determined 9 43421238 77421384 Mouse 1301435 Trigq1_m triglyceride QTL 1 (mouse) Not determined 9 44368699 78368787 Mouse 1301849 Derm1_m dermititis 1 (mouse) Not determined 9 44368699 78368787 Mouse 4141071 Ath29_m atherosclerosis 29 (mouse) Not determined 9 48263791 82263921 Mouse 4141668 Pstc6_m periosteal circumference 6 (mouse) Not determined 9 48425671 82425792 Mouse 4142230 Azdm3_m Alzheimer's disease modifier 3 (mouse) Not determined 9 48425671 82425792 Mouse 1300563 Pgia5_m proteoglycan induced arthritis 5 (mouse) Not determined 9 48771581 82771702 Mouse 1301051 Eae9_m susceptibility to experimental allergic encephalomyelitis 9 (mouse) Not determined 9 48771581 82771702 Mouse 1300716 Cd4ts4_m CD4 T cell subset 4 (mouse) Not determined 9 48771581 82771702 Mouse 1301049 El4_m epilepsy 4 (mouse) Not determined 9 49317103 67091973 Mouse 1301184 Bdln4_m body length 4 (mouse) Not determined 9 50091845 84091973 Mouse 1301549 Bbaa9_m B.burgdorferi-associated arthritis 9 (mouse) Not determined 9 54422152 88422279 Mouse 1558809 Lith20_m lithogenic gene 20 (mouse) Not determined 9 54422152 88422279 Mouse 4142254 Pbwg15_m postnatal body weight growth 15 (mouse) Not determined 9 55664157 89664432 Mouse 1357903 Gpdc3_m G protein deficiency-induced colitis 3 (mouse) Not determined 9 56379633 90379780 Mouse 4141676 Neogq1_m neonatal growth QTL 1 (mouse) Not determined 9 57745571 86133527 Mouse 1301914 Ksc1_m keratinocyte stem cell locus 1 (mouse) Not determined 9 58349562 92349700 Mouse 1301172 Fembrs6_m femur breaking strength 6 (mouse) Not determined 9 58964912 92965059 Mouse 1300848 Skull13_m skull morphology 13 (mouse) Not determined 9 59310471 93310653 Mouse 1300910 Taste11_m taste bitterness sensitivity 11 (mouse) Not determined 9 59310471 93310653 Mouse 1301133 Mob8_m multigenic obesity 8 (mouse) Not determined 9 59310471 93310653 Mouse 1301456 Adip5_m adiposity 5 (mouse) Not determined 9 59310471 93310653 Mouse 5491195 Mobq8_m multigenic obesity QTL 8 (mouse) Not determined 9 59310471 93310653 Mouse 1301611 Lrnx3_m learning contextual 3 (mouse) Not determined 9 62090292 96090406 Mouse 4141058 Blmpf3_m bleomycin-induced pulmonary fibrosis 3 (mouse) Not determined 9 62938718 96938857 Mouse Sequence Nucleotide Sequences Nucleotide RefSeqs NM_016769 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AAHY01078801 (Get FASTA) Search GEO for Microarray Profiles   AAHY01078802 (Get FASTA) Search GEO for Microarray Profiles   AAHY01078803 (Get FASTA) Search GEO for Microarray Profiles   AAHY01078804 (Get FASTA) Search GEO for Microarray Profiles   AAHY01078805 (Get FASTA) Search GEO for Microarray Profiles   AAHY01078806 (Get FASTA) Search GEO for Microarray Profiles   AAHY01078807 (Get FASTA) Search GEO for Microarray Profiles   AAHY01078808 (Get FASTA) Search GEO for Microarray Profiles   AAHY01078809 (Get FASTA) Search GEO for Microarray Profiles   AAHY01078810 (Get FASTA) Search GEO for Microarray Profiles   AAHY01078811 (Get FASTA) Search GEO for Microarray Profiles   AB008192 (Get FASTA) Search GEO for Microarray Profiles   AC158515 (Get FASTA) Search GEO for Microarray Profiles   AF016189 (Get FASTA) Search GEO for Microarray Profiles   AK030926 (Get FASTA) Search GEO for Microarray Profiles   AK041743 (Get FASTA) Search GEO for Microarray Profiles   AK048626 (Get FASTA) Search GEO for Microarray Profiles   AK083158 (Get FASTA) Search GEO for Microarray Profiles   AK190092 (Get FASTA) Search GEO for Microarray Profiles   AK190305 (Get FASTA) Search GEO for Microarray Profiles   AK192766 (Get FASTA) Search GEO for Microarray Profiles   AK210600 (Get FASTA) Search GEO for Microarray Profiles   AK219286 (Get FASTA) Search GEO for Microarray Profiles   BC022904 (Get FASTA) Search GEO for Microarray Profiles   BC025486 (Get FASTA) Search GEO for Microarray Profiles   BC066850 (Get FASTA) Search GEO for Microarray Profiles   CH466522 (Get FASTA) Search GEO for Microarray Profiles   CT010509 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_016769 RefSeq Status: VALIDATED Type: CODING Protein Acc Id: NP_058049 Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 9 63,646,767 - 63,757,994 - ENTREZGENE Mouse cM Map 9   - ENTREZGENE Mouse Celera Assembly 9 60,869,117 - 60,980,879 - RGD Mouse Genome Assembly Build 37 9 63,494,574 - 63,605,801 - RGD Protein Sequences Protein RefSeqs NP_058049 (Get FASTA) GenBank Protein AAB81755 (Get FASTA)   AAH22904 (Get FASTA)   AAH66850 (Get FASTA)   BAA76956 (Get FASTA)   BAC33398 (Get FASTA)   BAC38789 (Get FASTA)   BAE20601 (Get FASTA)   EDL26045 (Get FASTA)   Q8BUN5 (Get FASTA) Promoters RGD ID: 6848475 Promoter ID: MM_ACW:50896 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: BoneMarrow_0Hour,   Kidney Transcripts: SMAD3.FSEP07-UNSPLICED Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 9 63,498,751 - 63,499,251 - MPROMDB RGD ID: 6845178 Promoter ID: MM_KWN:57710 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: Kidney,   Lung Transcripts: OTTMUST00000050964 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 9 63,514,076 - 63,514,927 - MPROMDB RGD ID: 6845175 Promoter ID: MM_KWN:57711 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: Kidney,   Lung Transcripts: OTTMUST00000050961 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 9 63,559,521 - 63,560,277 - MPROMDB RGD ID: 6845177 Promoter ID: MM_KWN:57712 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: Liver,   Lung Transcripts: OTTMUST00000050962 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 9 63,590,811 - 63,591,717 - MPROMDB RGD ID: 6844142 Promoter ID: MM_KWN:57714 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: 3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen Transcripts: NM_016769,   UC009QBJ.1 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 9 63,605,681 - 63,606,202 - MPROMDB Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSMUSG00000032402 ENTREZGENE Ensembl Protein ENSMUSP00000034973 ENTREZGENE Ensembl Transcript ENSMUST00000034973 ENTREZGENE Entrez Gene 17127 ENTREZGENE Gene3D-CATH MAD_MH1 UniProtKB/Swiss-Prot   MH2_Dwarfin-type UniProtKB/Swiss-Prot Germonline ENSMUSG00000032402 HomoloGene Group ID 55937 ENTREZGENE InterPro Dwarfin UniProtKB/Swiss-Prot   MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot   MAD_homology_MH1 UniProtKB/Swiss-Prot   SMAD_dom-like UniProtKB/Swiss-Prot   SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot   SMAD_FHA_domain UniProtKB/Swiss-Prot IPI IPI00314870 UniProtKB/Swiss-Prot   IPI00808484 UniProtKB/TrEMBL   IPI00830220 UniProtKB/TrEMBL   IPI00830323 UniProtKB/TrEMBL   IPI00831542 UniProtKB/TrEMBL KEGG Report mmu:17127 ENTREZGENE, UniProtKB/Swiss-Prot MGD MGI:1201674 ENTREZGENE PANTHER Dwarfin UniProtKB/Swiss-Prot Pfam MH1 UniProtKB/Swiss-Prot   MH2 UniProtKB/Swiss-Prot PROSITE MH1 UniProtKB/Swiss-Prot   MH2 UniProtKB/Swiss-Prot SMART DWA UniProtKB/Swiss-Prot   DWB UniProtKB/Swiss-Prot Superfamily-SCOP MAD_MH1 UniProtKB/Swiss-Prot   SMAD_FHA UniProtKB/Swiss-Prot UniGene Mm.7320 ENTREZGENE UniProt A2CG44_MOUSE UniProtKB/TrEMBL   A2CG45_MOUSE UniProtKB/TrEMBL   F7BUP2_MOUSE UniProtKB/TrEMBL   Q05CN3_MOUSE UniProtKB/TrEMBL   Q3V3E0_MOUSE UniProtKB/TrEMBL   SMAD3_MOUSE UniProtKB/Swiss-Prot Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2012-07-10 Smad3  SMAD family member 3  Smad3  MAD homolog 3 (Drosophila)  Symbol and/or name change 39860 APPROVED

More on Smad3 Entrez Gene Ensembl Gene Genome Browser MGI Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 735647 Created: 2004-02-06 Species: Mus musculus Last Modified: 2013-04-30 Status: ACTIVE