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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad3
Name: SMAD family member 3
Acc ID: CHEBI:6052
Term: isorhamnetin
Definition: A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.
Chemical ID: MESH:C047368
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad3multiple interactionsISOSMAD3 (Homo sapiens)6480464CTD3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]PMID:27151496
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