SMAD3 (SMAD family member 3) - Rat Genome Database

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Gene: SMAD3 (SMAD family member 3) Pan paniscus
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Symbol: SMAD3
Name: SMAD family member 3
RGD ID: 11953502
Description: ENCODES a protein that exhibits beta-catenin binding (ortholog); DNA-binding transcription factor activity (ortholog); enzyme binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (ortholog); adrenal gland development (ortholog); apoptotic process (ortholog); PARTICIPATES IN activin signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; ASSOCIATED WITH alcoholic liver cirrhosis (ortholog); Aneurysm (ortholog); aortic aneurysm (ortholog); FOUND IN nucleus (ortholog); transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mothers against decapentaplegic homolog 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21656,319,096 - 56,448,455 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11560,491,695 - 60,621,061 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01546,013,764 - 46,143,126 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11564,284,949 - 64,414,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1564,284,949 - 64,414,185 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
activin receptor signaling pathway  (IEA)
adrenal gland development  (ISO)
anatomical structure morphogenesis  (IEA)
apoptotic process  (IEA,ISO)
cell differentiation  (IEA)
cell population proliferation  (IEA,ISO)
cell-cell junction organization  (IEA)
cellular response to glucose stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cellular response to virus  (IEA)
developmental growth  (IEA,ISO)
embryonic cranial skeleton morphogenesis  (IEA,ISO)
embryonic foregut morphogenesis  (IEA,ISO)
embryonic pattern specification  (IEA,ISO)
endoderm development  (IEA,ISO)
extrinsic apoptotic signaling pathway  (IEA)
gastrulation  (IEA,ISO)
heart looping  (IEA,ISO)
immune response  (IEA)
immune system development  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
JNK cascade  (IEA)
lens fiber cell differentiation  (IEA,ISO)
liver development  (IEA,ISO)
MAPK cascade  (IEA)
mesoderm formation  (IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (ISO)
negative regulation of cell growth  (IEA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cytosolic calcium ion concentration  (IEA)
negative regulation of fat cell differentiation  (IEA)
negative regulation of gene expression  (IEA,ISO)
negative regulation of inflammatory response  (IEA)
negative regulation of lung blood pressure  (ISO)
negative regulation of miRNA transcription  (IEA)
negative regulation of osteoblast differentiation  (IEA,ISO)
negative regulation of osteoblast proliferation  (IEA)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of wound healing  (IEA)
nodal signaling pathway  (IEA)
osteoblast development  (IEA,ISO)
osteoblast differentiation  (IEA)
paraxial mesoderm morphogenesis  (IEA,ISO)
pericardium development  (IEA,ISO)
positive regulation of alkaline phosphatase activity  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of chondrocyte differentiation  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of extracellular matrix assembly  (IEA,ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA)
positive regulation of positive chemotaxis  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transforming growth factor beta3 production  (ISO)
protein stabilization  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (IEA,ISO)
regulation of gene expression  (IEA)
regulation of immune response  (IEA)
regulation of striated muscle tissue development  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA)
regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
regulation of transforming growth factor beta2 production  (IEA)
response to angiotensin  (IEA,ISO)
response to hypoxia  (IEA)
response to transforming growth factor beta  (IEA,ISO)
signal transduction involved in regulation of gene expression  (ISO)
skeletal system development  (IEA,ISO)
SMAD protein signal transduction  (IEA,ISO)
somitogenesis  (IEA,ISO)
T cell activation  (IEA)
thyroid gland development  (IEA,ISO)
transdifferentiation  (ISO)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)
ureteric bud development  (IEA)

Cellular Component

Molecular Function
beta-catenin binding  (ISO)
bHLH transcription factor binding  (IEA)
chromatin binding  (IEA)
chromatin DNA binding  (IEA)
cis-regulatory region sequence-specific DNA binding  (IEA)
co-SMAD binding  (IEA)
collagen binding  (IEA)
DEAD/H-box RNA helicase binding  (IEA)
DNA binding  (IEA)
DNA-binding transcription activator activity, RNA polymerase II-specific  (IEA)
DNA-binding transcription factor activity  (IEA,ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific  (IEA)
DNA-binding transcription factor binding  (IEA)
DNA-binding transcription repressor activity  (IEA)
double-stranded DNA binding  (IEA)
enzyme binding  (ISO)
I-SMAD binding  (IEA)
identical protein binding  (IEA)
metal ion binding  (IEA)
nuclear glucocorticoid receptor binding  (IEA)
nuclear mineralocorticoid receptor binding  (IEA)
nuclear receptor binding  (IEA)
phosphatase binding  (IEA)
promoter-specific chromatin binding  (IEA)
protein binding  (ISO)
protein homodimerization activity  (IEA)
protein kinase binding  (IEA)
R-SMAD binding  (IEA)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (IEA)
RNA polymerase II transcription regulatory region sequence-specific DNA binding  (IEA)
RNA polymerase II-specific DNA-binding transcription factor binding  (IEA)
sequence-specific DNA binding  (IEA,ISO)
sterol response element binding  (IEA)
transcription cis-regulatory region binding  (IEA)
transcription coactivator binding  (IEA)
transcription corepressor binding  (IEA)
transcription factor binding  (ISO)
transforming growth factor beta receptor binding  (IEA)
ubiquitin binding  (IEA)
ubiquitin protein ligase binding  (IEA)
zinc ion binding  (IEA)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SMAD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21656,319,096 - 56,448,455 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11560,491,695 - 60,621,061 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01546,013,764 - 46,143,126 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11564,284,949 - 64,414,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1564,284,949 - 64,414,185 (+)Ensemblpanpan1.1panPan2
SMAD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381567,065,602 - 67,195,169 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1567,063,763 - 67,195,173 (+)EnsemblGRCh38hg38GRCh38
GRCh371567,357,940 - 67,487,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361565,145,249 - 65,274,587 (+)NCBINCBI36Build 36hg18NCBI36
Build 341565,145,248 - 65,274,586NCBI
Celera1544,246,635 - 44,375,039 (+)NCBICelera
Cytogenetic Map15q22.33NCBI
HuRef1544,193,465 - 44,321,904 (+)NCBIHuRef
CHM1_11567,476,260 - 67,605,488 (+)NCBICHM1_1
T2T-CHM13v2.01564,885,345 - 65,017,070 (+)NCBIT2T-CHM13v2.0
Smad3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,554,048 - 63,665,276 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl963,554,049 - 63,665,276 (-)EnsemblGRCm39 Ensembl
GRCm38963,646,766 - 63,757,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv37963,494,574 - 63,605,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36963,444,773 - 63,556,000 (-)NCBIMGSCv36mm8
Celera960,869,117 - 60,980,879 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.22NCBI
Smad3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,022,204 - 73,132,324 (-)NCBIGRCr8
mRatBN7.2864,126,829 - 64,236,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,110,039 - 64,236,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx869,641,910 - 69,752,073 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0867,914,370 - 68,024,539 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0865,784,499 - 65,894,665 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Celera863,537,497 - 63,647,062 (-)NCBICelera
Cytogenetic Map8q24NCBI
Smad3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554508,747,651 - 8,842,136 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554508,747,651 - 8,842,003 (-)NCBIChiLan1.0ChiLan1.0
SMAD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13031,246,313 - 31,360,098 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3031,245,657 - 31,363,337 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3031,175,971 - 31,289,442 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03031,444,224 - 31,557,937 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3031,444,224 - 31,561,176 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13031,371,657 - 31,485,227 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03031,431,846 - 31,545,247 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03031,673,713 - 31,787,293 (+)NCBIUU_Cfam_GSD_1.0
Smad3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640109,232,767 - 109,341,735 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647127,080,575 - 27,189,793 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647127,080,662 - 27,185,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1164,998,103 - 165,124,449 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11164,998,457 - 165,124,455 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,902,348 - 182,926,370 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12616,319,959 - 16,446,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2616,320,933 - 16,446,527 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048125,021,354 - 125,151,320 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247815,795,652 - 5,890,371 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247815,795,652 - 5,890,047 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000043962   ⟹   ENSPPAP00000021162
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1564,284,949 - 64,414,185 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000043998   ⟹   ENSPPAP00000021198
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1564,284,951 - 64,409,536 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000044006   ⟹   ENSPPAP00000021206
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1564,356,728 - 64,409,536 (+)Ensembl
RefSeq Acc Id: XM_003828004   ⟹   XP_003828052
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21656,319,096 - 56,448,455 (+)NCBI
NHGRI_mPanPan11560,491,695 - 60,621,061 (+)NCBI
Mhudiblu_PPA_v01546,013,764 - 46,143,126 (+)NCBI
PanPan1.11564,284,949 - 64,414,185 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034938998   ⟹   XP_034794889
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21656,321,401 - 56,448,455 (+)NCBI
NHGRI_mPanPan11560,493,988 - 60,621,061 (+)NCBI
Mhudiblu_PPA_v01546,016,053 - 46,143,126 (+)NCBI
RefSeq Acc Id: XM_055098613   ⟹   XP_054954588
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21656,319,106 - 56,448,455 (+)NCBI
NHGRI_mPanPan11560,491,695 - 60,621,061 (+)NCBI
RefSeq Acc Id: XM_055098614   ⟹   XP_054954589
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21656,319,525 - 56,448,455 (+)NCBI
NHGRI_mPanPan11560,492,123 - 60,621,061 (+)NCBI
RefSeq Acc Id: XM_055098615   ⟹   XP_054954590
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21656,352,460 - 56,448,455 (+)NCBI
NHGRI_mPanPan11560,525,059 - 60,621,061 (+)NCBI
RefSeq Acc Id: XM_063596748   ⟹   XP_063452818
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21656,391,490 - 56,448,455 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003828052   ⟸   XM_003828004
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AV36 (UniProtKB/TrEMBL),   A0A2R9AVI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034794889   ⟸   XM_034938998
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AV79 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000021162   ⟸   ENSPPAT00000043962
RefSeq Acc Id: ENSPPAP00000021198   ⟸   ENSPPAT00000043998
RefSeq Acc Id: ENSPPAP00000021206   ⟸   ENSPPAT00000044006
RefSeq Acc Id: XP_054954589   ⟸   XM_055098614
- Peptide Label: isoform X4
- UniProtKB: A0A2R9AVI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054954588   ⟸   XM_055098613
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AVI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054954590   ⟸   XM_055098615
- Peptide Label: isoform X6
- UniProtKB: A0A2R9AV79 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063452818   ⟸   XM_063596748
- Peptide Label: isoform X5
Protein Domains
MH1   MH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033769 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000043962.1 UniProtKB/TrEMBL
  ENSPPAT00000043998.1 UniProtKB/TrEMBL
  ENSPPAT00000044006.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/TrEMBL
KEGG Report pps:100993322 UniProtKB/TrEMBL
NCBI Gene SMAD3 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3 UniProtKB/TrEMBL
  PTHR13703 UniProtKB/TrEMBL
Pfam MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
PROSITE MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
SMART DWA UniProtKB/TrEMBL
  DWB UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/TrEMBL
  SSF56366 UniProtKB/TrEMBL
UniProt A0A2R9AV36 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AV79 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AVI0 ENTREZGENE, UniProtKB/TrEMBL