GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Smad3 | decreases expression | ISO | SMAD3 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of SMAD3 mRNA; Doxorubicin results in decreased expression of SMAD3 protein | PMID:18606404 PMID:29803840 | Smad3 | increases phosphorylation | ISO | Smad3 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of SMAD3 protein | PMID:28318631 | Smad3 | multiple interactions | ISO | SMAD3 (Homo sapiens) | 6480464 | CTD | Doxorubicin inhibits the reaction [TGFB1 protein results in increased localization of SMAD3 protein] | PMID:18606404 | Smad3 | multiple interactions | ISO | Smad3 (Mus musculus) | 6480464 | CTD | Niclosamide inhibits the reaction [Doxorubicin results in increased phosphorylation of SMAD3 protein] | PMID:28318631 | | ||||||||||||||||||||||
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