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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad3
Name: SMAD family member 3
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad3multiple interactionsEXP 6480464CTDDecitabine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]PMID:24211420
Smad3increases expressionISOSmad3 (Mus musculus)6480464CTDDecitabine results in increased expression of SMAD3 mRNAPMID:27915011
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