| 1-naphthyl isothiocyanate | multiple interactions | ISO | RGD:736957 | 6480464 | F3 protein promotes the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein]; more ... | CTD | PMID:21037076 |
| 1-naphthyl isothiocyanate | increases phosphorylation | ISO | RGD:736957 | 6480464 | 1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein | CTD | PMID:21037076 |
| 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:736957 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD2 mRNA | CTD | PMID:17942748 |
| 17beta-estradiol | decreases phosphorylation | ISO | RGD:736957 | 6480464 | Estradiol results in decreased phosphorylation of SMAD2 protein | CTD | PMID:17255206 |
| 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:736957 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD2 mRNA | CTD | PMID:17942748 |
| 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:736957 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SMAD2 mRNA | CTD | PMID:21570461 |
| 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:736957 | 6480464 | [Tetrachlorodibenzodioxin results in increased expression of TGFB1 protein] which results in increased activity of SMAD2 protein | CTD | PMID:18467041 |
| 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:736957 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SMAD2 protein | CTD | PMID:18467041 |
| 2,3,7,8-tetrachlorodibenzodioxine | increases activity | ISO | RGD:736957 | 6480464 | Tetrachlorodibenzodioxin results in increased activity of SMAD2 protein | CTD | PMID:18467041 |
| 2-acetamidofluorene | multiple interactions | EXP | | 6480464 | IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein] | CTD | PMID:15368444 |
| 2-amino-2-deoxy-D-glucopyranose | multiple interactions | ISO | RGD:1347299 | 6480464 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucosamine analog results in increased phosphorylation of SMAD2 protein] | CTD | PMID:20458730 |
| 2-amino-2-deoxy-D-glucopyranose | increases phosphorylation | ISO | RGD:1347299 | 6480464 | Glucosamine analog results in increased phosphorylation of SMAD2 protein | CTD | PMID:20458730 |
| 2-methoxyethanol | increases expression | EXP | | 6480464 | methyl cellosolve results in increased expression of SMAD2 mRNA | CTD | PMID:21061450 |
| 3,4-dihydroxybenzaldehyde | multiple interactions | ISO | RGD:1347299 | 6480464 | protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein]; more ... | CTD | PMID:17597607 |
| 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in decreased expression of SMAD2 mRNA | CTD | PMID:19162173 |
| aldehydo-D-glucosamine | multiple interactions | ISO | RGD:1347299 | 6480464 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucosamine analog results in increased phosphorylation of SMAD2 protein] | CTD | PMID:20458730 |
| aldehydo-D-glucosamine | increases phosphorylation | ISO | RGD:1347299 | 6480464 | Glucosamine analog results in increased phosphorylation of SMAD2 protein | CTD | PMID:20458730 |
| all-trans-retinoic acid | increases phosphorylation | ISO | RGD:1347299 | 6480464 | Tretinoin results in increased phosphorylation of SMAD2 protein | CTD | PMID:17098229 |
| all-trans-retinoic acid | decreases expression | ISO | RGD:736957 | 6480464 | Tretinoin results in decreased expression of SMAD2 mRNA | CTD | PMID:18703560 |
| all-trans-retinoic acid | multiple interactions | ISO | RGD:1347299 | 6480464 | Tretinoin inhibits the reaction [TGFB1 results in increased phosphorylation of and results in increased localization of SMAD2 protein] | CTD | PMID:21274875 |
| all-trans-retinoic acid | decreases expression | ISO | RGD:1347299 | 6480464 | Tretinoin results in decreased expression of SMAD2 mRNA | CTD | PMID:15498508 |
| all-trans-retinoic acid | multiple interactions | ISO | RGD:1347299 | 6480464 | Tamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD2 protein] | CTD | PMID:17098229 |
| all-trans-retinoic acid | decreases phosphorylation | ISO | RGD:736957 | 6480464 | Tretinoin results in decreased phosphorylation of SMAD2 protein | CTD | PMID:16410076 |
| amlodipine | multiple interactions | ISO | RGD:1347299 | 6480464 | Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased phosphorylation of SMAD2 protein] | CTD | PMID:21337027 |
| ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SMAD2 mRNA | CTD | PMID:16483693 |
| atrazine | multiple interactions | ISO | RGD:1347299 | 6480464 | [Atrazine co-treated with Arsenates] results in increased expression of SMAD2 mRNA | CTD | PMID:18585445 |
| benazepril | affects expression | EXP | | 6480464 | benazepril affects the expression of SMAD2 mRNA; more ... | CTD | PMID:16635409 |
| benazepril | multiple interactions | EXP | | 6480464 | [benazepril co-treated with irbesartan] affects the expression of SMAD2 protein; more ... | CTD | PMID:16635409 |
| benzo[a]pyrene | multiple interactions | ISO | RGD:736957 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of SMAD2 mRNA | CTD | PMID:21715664 |
| beta-D-glucosamine | multiple interactions | ISO | RGD:1347299 | 6480464 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucosamine analog results in increased phosphorylation of SMAD2 protein] | CTD | PMID:20458730 |
| beta-D-glucosamine | increases phosphorylation | ISO | RGD:1347299 | 6480464 | Glucosamine analog results in increased phosphorylation of SMAD2 protein | CTD | PMID:20458730 |
| cobalt dichloride | decreases expression | ISO | RGD:1347299 | 6480464 | cobaltous chloride results in decreased expression of SMAD2 mRNA | CTD | PMID:19320972 PMID:19376846 |
| coumestrol | multiple interactions | ISO | RGD:1347299 | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD2 mRNA | CTD | PMID:19167446 |
| crocidolite asbestos | affects expression | ISO | RGD:1347299 | 6480464 | Asbestos, Crocidolite affects the expression of SMAD2 mRNA | CTD | PMID:17331233 |
| crocidolite asbestos | increases phosphorylation | ISO | RGD:1347299 | 6480464 | Asbestos, Crocidolite results in increased phosphorylation of SMAD2 protein | CTD | PMID:17975199 |
| cyclosporin A | multiple interactions | ISO | RGD:736957 | 6480464 | bisindolylmaleimide I inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein]; more ... | CTD | PMID:22155090 |
| D-glucose | multiple interactions | ISO | RGD:1347299 | 6480464 | Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein; more ... | CTD | PMID:17597607 |
| D-glucose | increases phosphorylation | ISO | RGD:1347299 | 6480464 | Glucose results in increased phosphorylation of SMAD2 protein | CTD | PMID:21367880 |
| D-glucose | multiple interactions | ISO | RGD:1347299 | 6480464 | isoangustone A inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein] | CTD | PMID:21367880 |
| diethylstilbestrol | decreases phosphorylation | ISO | RGD:736957 | 6480464 | Diethylstilbestrol results in decreased phosphorylation of SMAD2 protein | CTD | PMID:17255206 |
| dioxygen | multiple interactions | ISO | RGD:736957 | 6480464 | rosiglitazone inhibits the reaction [Oxygen deficiency results in increased phosphorylation of SMAD2 protein] | CTD | PMID:21531777 |
| dioxygen | increases phosphorylation | ISO | RGD:736957 | 6480464 | Oxygen deficiency results in increased phosphorylation of SMAD2 protein | CTD | PMID:21531777 |
| doxorubicin | decreases expression | ISO | RGD:1347299 | 6480464 | Doxorubicin results in decreased expression of SMAD2 protein | CTD | PMID:18606404 |
| doxorubicin | increases expression | EXP | | 6480464 | Doxorubicin results in increased expression of SMAD2 mRNA | CTD | PMID:21337027 |
| doxorubicin | multiple interactions | ISO | RGD:1347299 | 6480464 | Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased phosphorylation of SMAD2 protein]; more ... | CTD | PMID:21337027 |
| enalapril | multiple interactions | EXP | | 6480464 | Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein] | CTD | PMID:17513326 |
| ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of SMAD2 mRNA | CTD | PMID:17920746 |
| etoposide | multiple interactions | ISO | RGD:1347299 | 6480464 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Etoposide results in increased phosphorylation of SMAD2 protein] | CTD | PMID:22363485 |
| etoposide | increases phosphorylation | ISO | RGD:1347299 | 6480464 | Etoposide results in increased phosphorylation of SMAD2 protein | CTD | PMID:22363485 |
| glucose | multiple interactions | ISO | RGD:1347299 | 6480464 | Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein; more ... | CTD | PMID:17597607 |
| glucose | multiple interactions | ISO | RGD:1347299 | 6480464 | isoangustone A inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein] | CTD | PMID:21367880 |
| glucose | increases phosphorylation | ISO | RGD:1347299 | 6480464 | Glucose results in increased phosphorylation of SMAD2 protein | CTD | PMID:21367880 |
| hispidin | multiple interactions | ISO | RGD:736957 | 6480464 | hispidin inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein] | CTD | PMID:22155090 |
| hydrogen peroxide | increases phosphorylation | ISO | RGD:1347299 | 6480464 | Hydrogen Peroxide results in increased phosphorylation of SMAD2 protein | CTD | PMID:15147944 |
| hydrogen peroxide | multiple interactions | ISO | RGD:1347299 | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD2 protein | CTD | PMID:18951874 |
| irbesartan | multiple interactions | EXP | | 6480464 | [benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA; more ... | CTD | PMID:16635409 |
| irbesartan | affects expression | EXP | | 6480464 | irbesartan affects the expression of SMAD2 protein; more ... | CTD | PMID:16635409 |
| melphalan | multiple interactions | ISO | RGD:1347299 | 6480464 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Melphalan results in increased phosphorylation of SMAD2 protein] | CTD | PMID:22363485 |
| melphalan | increases phosphorylation | ISO | RGD:1347299 | 6480464 | Melphalan results in increased phosphorylation of SMAD2 protein | CTD | PMID:22363485 |
| mercury atom | increases expression | ISO | RGD:1347299 | 6480464 | Mercury results in increased expression of SMAD2 mRNA | CTD | PMID:19937285 |
| mercury(0) | increases expression | ISO | RGD:1347299 | 6480464 | Mercury results in increased expression of SMAD2 mRNA | CTD | PMID:19937285 |
| mitoxantrone | affects response to substance | ISO | RGD:1347299 | 6480464 | SMAD2 protein affects the susceptibility to Mitoxantrone | CTD | PMID:16217747 |
| N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:736957 | 6480464 | Ethylnitrosourea results in increased mutagenesis of SMAD2 gene | CTD | PMID:16724327 |
| N-methyl-N'-nitro-N-nitrosoguanidine | decreases expression | ISO | RGD:1347299 | 6480464 | Methylnitronitrosoguanidine results in decreased expression of SMAD2 mRNA | CTD | PMID:12634122 |
| N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein; more ... | CTD | PMID:15368444 |
| N-nitrosodiethylamine | decreases phosphorylation | EXP | | 6480464 | Diethylnitrosamine results in decreased phosphorylation of SMAD2 protein | CTD | PMID:18971187 |
| N-nitrosodimethylamine | increases phosphorylation | EXP | | 6480464 | Dimethylnitrosamine results in increased phosphorylation of SMAD2 protein | CTD | PMID:14568256 |
| N-nitrosodimethylamine | multiple interactions | EXP | | 6480464 | Leu-Ser-Lys-Leu peptide inhibits the reaction [Dimethylnitrosamine results in increased phosphorylation of SMAD2 protein] | CTD | PMID:14568256 |
| paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SMAD2 mRNA | CTD | PMID:16701773 |
| paricalcitol | multiple interactions | EXP | | 6480464 | Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein] | CTD | PMID:17513326 |
| paricalcitol | decreases phosphorylation | EXP | | 6480464 | paricalcitol results in decreased phosphorylation of SMAD2 protein | CTD | PMID:17513326 |
| phenobarbital | affects expression | ISO | RGD:1347299 | 6480464 | Phenobarbital affects the expression of SMAD2 mRNA | CTD | PMID:19159669 |
| phenylephrine | multiple interactions | EXP | | 6480464 | Phenylephrine results in increased phosphorylation of and results in increased localization of and results in increased activity of SMAD2 protein | CTD | PMID:19443575 |
| phorbol 13-acetate 12-myristate | multiple interactions | ISO | RGD:736957 | 6480464 | Tetradecanoylphorbol Acetate results in increased expression of and affects the localization of SMAD2 protein; more ... | CTD | PMID:20172950 |
| phorbol 13-acetate 12-myristate | increases expression | ISO | RGD:736957 | 6480464 | Tetradecanoylphorbol Acetate results in increased expression of SMAD2 protein | CTD | PMID:20172950 |
| progesterone | affects expression | ISO | RGD:736957 | 6480464 | Progesterone affects the expression of SMAD2 mRNA | CTD | PMID:17251523 |
| resveratrol | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD2 protein] | CTD | PMID:21300041 |
| resveratrol | decreases expression | ISO | RGD:1347299 | 6480464 | resveratrol results in decreased expression of SMAD2 mRNA; more ... | CTD | PMID:18089832 |
| resveratrol | decreases phosphorylation | ISO | RGD:736957 | 6480464 | resveratrol results in decreased phosphorylation of SMAD2 protein | CTD | PMID:21679764 |
| rosiglitazone | multiple interactions | ISO | RGD:736957 | 6480464 | rosiglitazone inhibits the reaction [Oxygen deficiency results in increased phosphorylation of SMAD2 protein] | CTD | PMID:21531777 |
| silver(1+) nitrate | decreases expression | ISO | RGD:1347299 | 6480464 | Silver Nitrate analog results in decreased expression of SMAD2 mRNA | CTD | PMID:22831968 |
| silver(1+) nitrate | increases expression | ISO | RGD:1347299 | 6480464 | Silver Nitrate results in increased expression of SMAD2 mRNA | CTD | PMID:22831968 |
| simvastatin | decreases phosphorylation | EXP | | 6480464 | Simvastatin results in decreased phosphorylation of SMAD2 protein | CTD | PMID:19659652 |
| simvastatin | increases expression | ISO | RGD:736957 | 6480464 | Simvastatin results in increased expression of SMAD2 mRNA | CTD | PMID:18310456 |
| streptozocin | increases phosphorylation | EXP | | 6480464 | Streptozocin results in increased phosphorylation of SMAD2 protein | CTD | PMID:21300041 |
| streptozocin | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD2 protein] | CTD | PMID:21300041 |
| tamibarotene | decreases expression | ISO | RGD:1347299 | 6480464 | Am 80 results in decreased expression of SMAD2 mRNA; more ... | CTD | PMID:15498508 |
| tamibarotene | increases phosphorylation | ISO | RGD:1347299 | 6480464 | Am 80 results in increased phosphorylation of SMAD2 protein; more ... | CTD | PMID:17611697 |
| tamoxifen | multiple interactions | ISO | RGD:1347299 | 6480464 | Tamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD2 protein] | CTD | PMID:17098229 |
| tamoxifen | increases phosphorylation | ISO | RGD:1347299 | 6480464 | Tamoxifen results in increased phosphorylation of SMAD2 protein | CTD | PMID:17098229 |
| tetrachloromethane | affects response to substance | ISO | RGD:736957 | 6480464 | SMAD2 protein affects the susceptibility to Carbon Tetrachloride | CTD | PMID:16382155 |
| tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SMAD2 mRNA | CTD | PMID:16570350 |
| theophylline | multiple interactions | ISO | RGD:1347299 | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD2 protein | CTD | PMID:18951874 |
| thioacetamide | multiple interactions | EXP | | 6480464 | Lipopolysaccharides promotes the reaction [Thioacetamide results in increased expression of SMAD2 mRNA] | CTD | PMID:17621560 |
| thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SMAD2 mRNA | CTD | PMID:17621560 |
| trans-resveratrol | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD2 protein] | CTD | PMID:21300041 |
| trans-resveratrol | decreases expression | ISO | RGD:1347299 | 6480464 | resveratrol results in decreased expression of SMAD2 mRNA; more ... | CTD | PMID:18089832 |
| trans-resveratrol | decreases phosphorylation | ISO | RGD:736957 | 6480464 | resveratrol results in decreased phosphorylation of SMAD2 protein | CTD | PMID:21679764 |
| trichloroethene | increases expression | ISO | RGD:736957 | 6480464 | Trichloroethylene results in increased expression of SMAD2 mRNA | CTD | PMID:19448997 |
| troglitazone | multiple interactions | ISO | RGD:1347299 | 6480464 | troglitazone inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD2 protein] | CTD | PMID:18253093 |
| valproic acid | decreases expression | ISO | RGD:736957 | 6480464 | Valproic Acid results in decreased expression of SMAD2 mRNA | CTD | PMID:21427059 |
| vancomycin | decreases expression | ISO | RGD:736957 | 6480464 | Vancomycin results in decreased expression of SMAD2 mRNA | CTD | PMID:18930951 |
| zinc atom | multiple interactions | ISO | RGD:736957 | 6480464 | Zinc promotes the reaction [SMAD3 protein modified form binds to SMAD2 protein modified form binds to NFIC protein] | CTD | PMID:22228435 |
| zinc(0) | multiple interactions | ISO | RGD:736957 | 6480464 | Zinc promotes the reaction [SMAD3 protein modified form binds to SMAD2 protein modified form binds to NFIC protein] | CTD | PMID:22228435 |