GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Smad3 | decreases phosphorylation | ISO | SMAD3 (Homo sapiens) | 6480464 | CTD | Acetylcysteine results in decreased phosphorylation of SMAD3 protein | PMID:34687772 | Smad3 | multiple interactions | ISO | SMAD3 (Homo sapiens) | 6480464 | CTD | [Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA; [Acetylcysteine co-treated with Cadmium] results in decreased expression of SMAD3 mRNA; [Acetylcysteine co-treated with Water Pollutants, Chemical] results in decreased expression of SMAD3 mRNA; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of SMAD3 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] | PMID:21131394 PMID:29408318 PMID:30317545 PMID:34687772 | |
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