Srebf1 (sterol regulatory element binding transcription factor 1) - Rat Genome Database

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Gene: Srebf1 (sterol regulatory element binding transcription factor 1) Rattus norvegicus
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Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
RGD ID: 69423
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including response to fructose; response to peptide hormone; and response to progesterone. Part of protein-containing complex. Biomarker of alcoholic hepatitis; diabetic neuropathy; kidney disease; lipid storage disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease; disease of metabolism; and type 2 diabetes mellitus. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1); PARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; insulin signaling pathway; INTERACTS WITH (+)-catechin; (-)-cotinine; (25R)-cholest-5-ene-3beta,26-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADD-1; ADD1; adipocyte determination- and differentiation-dependent factor 1; SREBP-1; SREBP-1c; Srebp1; sterol regulatory element binding factor 1; sterol regulatory element-binding protein 1; sterol regulatory element-binding transcription factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Srebf1_v1   Srebf1_v2  
Is Marker For: Strains:   SHR.BN-(D10Mgh3-Srebf1)/Ipcv  
QTLs:   Hpcl2  
Candidate Gene For: Hpcl1 Hpcl2
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,507,152 - 45,529,164 (-)NCBIGRCr8
mRatBN7.21045,007,637 - 45,029,650 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,007,637 - 45,029,650 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,707,833 - 49,729,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01049,198,201 - 49,220,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,701,803 - 44,723,821 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,570,996 - 46,593,021 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,570,996 - 46,593,009 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,326,015 - 46,348,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,461,684 - 46,483,646 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1044,264,866 - 44,286,830 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-isolariciresinol  (ISO)
(+)-pinoresinol  (ISO)
(-)-cotinine  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,10-phenanthroline  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-deoxy-D-glucose  (ISO)
2-naphthylamine  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (EXP)
28-Homobrassinolide  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (EXP,ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
8-Br-cAMP  (ISO)
9-cis,11-trans-octadecadienoic acid  (ISO)
9-cis-retinoic acid  (ISO)
acadesine  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
Acetyl tributyl citrate  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
Aescin  (ISO)
aflatoxin B1  (EXP,ISO)
alcohol  (ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alliin  (ISO)
allopurinol  (EXP,ISO)
alpha-D-galactose  (ISO)
alpha-linolenic acid  (EXP)
alpha-pinene  (ISO)
amentoflavone  (ISO)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP,ISO)
Azaspiracid  (ISO)
AZD4547  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzylpenicillin  (ISO)
berberine  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (ISO)
betulin  (ISO)
bexarotene  (EXP,ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
boric acid  (ISO)
brexpiprazole  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butyric acid  (ISO)
C60 fullerene  (EXP)
Cacalol  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capivasertib  (ISO)
capsaicin  (ISO)
carbamazepine  (EXP)
carbendazim  (ISO)
CARBENOXOLONE  (EXP)
carbon nanotube  (ISO)
carvedilol  (EXP)
cerivastatin  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (EXP)
chloroethene  (ISO)
chlorpyrifos  (EXP)
cholate  (EXP)
cholesterol  (ISO)
choline  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
citalopram  (ISO)
clavulanic acid  (ISO)
clofazimine  (EXP)
clofibrate  (EXP,ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cordycepin  (ISO)
corn oil  (EXP)
corticosterone  (EXP,ISO)
cortisol  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP,ISO)
D-gluconic acid  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dabrafenib  (ISO)
dapagliflozin  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
deoxypodophyllotoxin  (ISO)
depsipeptide  (ISO)
desferrioxamine B  (ISO)
desmosterol  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
dihydroartemisinin  (EXP,ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
elemental selenium  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
erythromycin A  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ezetimibe  (ISO)
fenofibrate  (EXP,ISO)
fentin chloride  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
galactose  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
Gastrodin  (ISO)
gefitinib  (ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
Gingerenone A  (ISO)
ginsenoside Re  (ISO)
Ginsenoside Rh4  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycerol 2-phosphate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (EXP,ISO)
GW 3965  (EXP,ISO)
GW 4064  (ISO)
GW 6471  (ISO)
GW 7647  (ISO)
herbacetin  (ISO)
hexadecanoic acid  (EXP,ISO)
Honokiol  (EXP)
hydrazines  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (ISO)
imipramine  (ISO)
indole-3-methanol  (EXP)
insulin  (EXP,ISO)
iron dichloride  (ISO)
isosilybin  (ISO)
kahweol  (ISO)
ketamine  (EXP)
ketotifen  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP,ISO)
L-serine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
linoleic acid  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
loliolide  (ISO)
losartan  (EXP)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
magnesium atom  (EXP)
Magnolol  (EXP)
melatonin  (ISO)
metformin  (EXP,ISO)
methyl methanesulfonate  (ISO)
metronidazole  (ISO)
mevastatin  (EXP,ISO)
microcystin-LR  (ISO)
miquelianin  (EXP)
mirtazapine  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (EXP,ISO)
Morroniside  (ISO)
Muraglitazar  (EXP)
myricetin  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methylformamide  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naloxone  (EXP)
naringin  (ISO)
nefazodone  (EXP,ISO)
nelfinavir  (ISO)
neomycin  (ISO)
nevirapine  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nimesulide  (EXP)
nordihydroguaiaretic acid  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
olanzapine  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
oleuropein  (EXP)
Olmesartan medoxomil  (EXP)
orlistat  (ISO)
oroxylin A  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paxilline  (ISO)
PD 168393  (EXP)
penconazole  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
picolinic acid  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
propamocarb  (ISO)
propiconazole  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
raffinose  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
risperidone  (ISO)
ritonavir  (ISO)
rosiglitazone  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salubrinal  (EXP)
SB 431542  (ISO)
scopoletin  (EXP)
selenium atom  (EXP,ISO)
selenomethionine  (ISO)
senecionine  (ISO)
silibinin  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenite  (EXP,ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP)
Sodium oleate  (ISO)
Sophocarpine  (EXP)
starch  (EXP)
stavudine  (EXP)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
sulfluramid  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tauroursodeoxycholic acid  (EXP)
tebuconazole  (ISO)
tectorigenin  (ISO)
testosterone  (ISO)
testosterone cypionate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
tetramethylpyrazine  (ISO)
thapsigargin  (EXP,ISO)
theophylline  (EXP)
thioacetamide  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
tianeptine  (ISO)
topiramate  (EXP)
trametinib  (ISO)
trans-caffeic acid  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP,ISO)
triclosan  (ISO)
triolein  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
Tris(2-ethylhexyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
tunicamycin  (EXP,ISO)
tyloxapol  (ISO)
tyrphostin AG 1478  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vanillic acid  (ISO)
vemurafenib  (ISO)
vincristine  (ISO)
vitamin D  (ISO)
withaferin A  (ISO)
wortmannin  (EXP)
xanthohumol  (ISO)
xylose  (ISO)
Y-27632  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to fatty acid  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to starvation  (IDA,ISO)
cholesterol biosynthetic process  (ISO)
cholesterol metabolic process  (IMP)
circadian rhythm  (ISO)
fat cell differentiation  (ISO)
insulin receptor signaling pathway  (ISO)
insulin secretion  (ISO)
intracellular receptor signaling pathway  (IEA)
lipid biosynthetic process  (ISO,ISS,TAS)
lung development  (IEP)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of triglyceride metabolic process  (ISO)
positive regulation of cholesterol biosynthetic process  (ISO,ISS)
positive regulation of DNA-templated transcription  (IMP,ISO)
positive regulation of innate immune response  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of triglyceride biosynthetic process  (ISO,ISS)
regulation of DNA-templated transcription  (ISO)
regulation of fatty acid metabolic process  (ISO)
regulation of heart rate by chemical signal  (ISO)
regulation of insulin secretion  (ISO)
regulation of lipid storage  (IEP)
regulation of mitophagy  (ISO)
regulation of protein stability  (ISO)
regulation of protein targeting to mitochondrion  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO,ISS)
response to cAMP  (IEP)
response to ethanol  (IEP)
response to fatty acid  (IEP)
response to food  (IEP)
response to fructose  (IEP)
response to glucagon  (IEP)
response to glucose  (ISO)
response to insulin  (TAS)
response to lipid  (IEP)
response to nutrient  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
response to progesterone  (IEP)
response to retinoic acid  (IEP)
response to xenobiotic stimulus  (IEP)
SREBP signaling pathway  (ISO,ISS)
transcription by RNA polymerase II  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47. Amemiya-Kudo M, etal., J Biol Chem. 2005 Oct 14;280(41):34577-89. Epub 2005 Jul 29.
2. Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors. Boizard M, etal., J Biol Chem. 1998 Oct 30;273(44):29164-71.
3. Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue. Bonzon-Kulichenko E, etal., Endocrinology. 2009 Jan;150(1):169-78. Epub 2008 Sep 18.
4. Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways. Botolin D, etal., J Lipid Res. 2006 Jan;47(1):181-92. Epub 2005 Oct 12.
5. HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus. Carper MJ, etal., Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E558-67. Epub 2008 Jan 2.
6. Arctium lappa L. polysaccharide can regulate lipid metabolism in type 2 diabetic rats through the SREBP-1/SCD-1 axis. Chen M, etal., Carbohydr Res. 2020 Aug;494:108055. doi: 10.1016/j.carres.2020.108055. Epub 2020 Jun 7.
7. Protective effect of Chinese prescription Kangen-karyu and its crude drug Tanjin against age-related lipidosis in rats. Cho EJ, etal., J Pharm Pharmacol. 2007 May;59(5):687-94.
8. Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. Costet P, etal., J Biol Chem. 2006 Mar 10;281(10):6211-8. Epub 2006 Jan 6.
9. Programmed upregulation of adipogenic transcription factors in intrauterine growth-restricted offspring. Desai M, etal., Reprod Sci. 2008 Oct;15(8):785-96.
10. Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice. Doddapattar P, etal., Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3.
11. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Foretz M, etal., Mol Cell Biol. 1999 May;19(5):3760-8.
12. [Effects of wheat bran fiber on lipid metabolism in ApoE~(-/-) mice]. Gao H, etal., Wei Sheng Yan Jiu. 2019 Jul;48(4):601-605.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
16. Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis. Hu YB, etal., Drug Des Devel Ther. 2018 Jul 16;12:2213-2221. doi: 10.2147/DDDT.S170518. eCollection 2018.
17. Involvement of glomerular SREBP-1c in diabetic nephropathy. Ishigaki N, etal., Biochem Biophys Res Commun. 2007 Dec 21;364(3):502-8. Epub 2007 Oct 16.
18. Calorie restriction modulates renal expression of sterol regulatory element binding proteins, lipid accumulation, and age-related renal disease. Jiang T, etal., J Am Soc Nephrol. 2005 Aug;16(8):2385-94. Epub 2005 Jun 8.
19. In vivo and in vitro effects of SREBP-1 on diabetic renal tubular lipid accumulation and RNAi-mediated gene silencing study. Jun H, etal., Histochem Cell Biol. 2009 Mar;131(3):327-45. Epub 2008 Dec 2.
20. Cilostazol inhibits insulin-stimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1. Jung YA, etal., Exp Mol Med. 2014 Jan 24;46(1):e73. doi: 10.1038/emm.2013.143.
21. Testosterone stimulates cholesterol clearance from human macrophages by activating LXRα. Kilby EL, etal., Life Sci. 2021 Mar 15;269:119040. doi: 10.1016/j.lfs.2021.119040. Epub 2021 Jan 13.
22. Development of ligand-dependent regulatory system and its application to gene therapy of insulin-dependent diabetes mellitus. Kim JM, etal., Exp Mol Med. 2006 Aug 31;38(4):385-92.
23. Progesterone stimulates adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c gene expression. potential mechanism for the lipogenic effect of progesterone in adipose tissue. Lacasa D, etal., J Biol Chem. 2001 Apr 13;276(15):11512-6. Epub 2001 Jan 16.
24. Therapeutic Effect of Gypenosides on Nonalcoholic Steatohepatitis via Regulating Hepatic Lipogenesis and Fatty Acid Oxidation. Li H, etal., Biol Pharm Bull. 2017;40(5):650-657. doi: 10.1248/bpb.b16-00942.
25. Atorvastatin reduces alcohol-induced endoplasmic reticulum stress in AC16 cardiomyocytes. Li N, etal., Scand Cardiovasc J. 2019 Feb;53(1):42-47. doi: 10.1080/14017431.2018.1516891.
26. Increased renal collagen cross-linking and lipid accumulation in nephropathy of Zucker diabetic fatty rats. Li Y, etal., Diabetes Metab Res Rev. 2008 Sep;24(6):498-506.
27. Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population. Liu JX, etal., Diabetes Res Clin Pract. 2008 Oct;82(1):42-7. Epub 2008 Aug 8.
28. Dietary α-lactalbumin induced fatty liver by enhancing nuclear liver X receptor αβ/sterol regulatory element-binding protein-1c/PPARγ expression and minimising PPARα/carnitine palmitoyltransferase-1 expression and AMP-activated protein kinase α phosphorylation associated with atherogenic dyslipidaemia, insulin resistance and oxidative stress in Balb/c mice. López-Oliva ME, etal., Br J Nutr. 2017 Dec;118(11):914-929. doi: 10.1017/S000711451700232X. Epub 2017 Nov 27.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Naltrexone changes the expression of lipid metabolism-related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice. Moslehi A, etal., Clin Exp Pharmacol Physiol. 2017 Feb;44(2):207-212. doi: 10.1111/1440-1681.12695.
31. Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha. Nagai Y, etal., Am J Physiol Endocrinol Metab 2002 May;282(5):E1180-90.
32. Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. Nakamura S, etal., J Biol Chem. 2009 May 29;284(22):14809-18. doi: 10.1074/jbc.M901488200. Epub 2009 Mar 30.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Osborne TF and Espenshade PJ, Genes Dev. 2009 Nov 15;23(22):2578-91.
35. Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. Ota T, etal., Gastroenterology. 2007 Jan;132(1):282-93. Epub 2006 Oct 12.
36. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. Ou J, etal., Proc Natl Acad Sci U S A 2001 May 22;98(11):6027-32.
37. Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia. Pallottini V, etal., J Cell Biochem. 2006 Aug 1;98(5):1044-53.
38. Liver X receptor activation enhances CVB3 viral replication during myocarditis by stimulating lipogenesis. Papageorgiou AP, etal., Cardiovasc Res. 2015 Jul 1;107(1):78-88. doi: 10.1093/cvr/cvv157. Epub 2015 May 21.
39. Role of SREBP-1 in the Development of Parasympathetic Dysfunction in the Hearts of Type 1 Diabetic Akita Mice. Park HJ, etal., Circ Res. 2009 May 7.
40. Down-regulated of SREBP-1 in circulating leukocyte is a risk factor for atherosclerosis: a case control study. Peng C, etal., Lipids Health Dis. 2019 Oct 14;18(1):177. doi: 10.1186/s12944-019-1125-1.
41. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
42. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
43. Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat. Pravenec M, etal., Hypertension. 2008 Jan;51(1):148-53. Epub 2007 Dec 10.
44. Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat. Pravenec M, etal., Mamm Genome 2001 Apr;12(4):295-8.
45. Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes. Proctor G, etal., Diabetes. 2006 Sep;55(9):2502-9.
46. Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study. Pérez-Belmonte LM, etal., Int J Med Sci. 2017 Feb 23;14(3):268-274. doi: 10.7150/ijms.17821. eCollection 2017.
47. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Repa JJ, etal., Genes Dev. 2000 Nov 15;14(22):2819-30.
48. GOA pipeline RGD automated data pipeline
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Interaction between SREBP-1a and APOB polymorphisms influences total and low-density lipoprotein cholesterol levels in patients with coronary artery disease. Rios DL, etal., Clin Genet. 2003 May;63(5):380-5. doi: 10.1034/j.1399-0004.2003.00057.x.
52. Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance. Sajan MP, etal., Diabetologia. 2009 Jun;52(6):1197-207. Epub 2009 Apr 9.
53. An adipogenic basic helix-loop-helix-leucine zipper type transcription factor (ADD1) mRNA is expressed and regulated by retinoic acid in osteoblastic cells. Sawada Y and Noda M, Mol Endocrinol. 1996 Oct;10(10):1238-48.
54. Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus.PG - Sun L, etal., J Biol Chem 2002 May 24;277(21):18919-27.
55. Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status. Tamehiro N, etal., J Biol Chem. 2007 Jul 20;282(29):21090-9. Epub 2007 May 27.
56. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
57. (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B. Wang W, etal., Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018.
58. Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Wang Z, etal., Diabetes. 2005 Aug;54(8):2328-35.
59. Cyclosporin-induced dyslipoproteinemia is associated with selective activation of SREBP-2. Wu J, etal., Am J Physiol. 1999 Dec;277(6 Pt 1):E1087-94.
60. Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms. Xu J, etal., J Nutr. 2002 Nov;132(11):3333-9.
61. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
62. Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles. Yellaturu CR, etal., J Biol Chem. 2009 Mar 20;284(12):7518-32. Epub 2009 Jan 21.
63. Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes. Yin HQ, et al., Toxicol Appl Pharmacol. 2009 Apr 1;236(1):124-30. doi: 10.1016/j.taap.2008.12.030. Epub 2009 Jan 24.
64. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). You M, etal., J Biol Chem 2002 Aug 9;277(32):29342-7.
65. Lipogenesis in fetal rat lung: importance of C/EBPalpha, SREBP-1c, and stearoyl-CoA desaturase. Zhang F, etal., Am J Respir Cell Mol Biol 2004 Feb;30(2):174-83. Epub 2003 Aug 01.
66. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
67. Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD. Zhang Y, etal., J Ethnopharmacol. 2021 Feb 10;266:113436. doi: 10.1016/j.jep.2020.113436. Epub 2020 Oct 1.
68. Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p/SREBP-1c axis. Zhong H, etal., FEBS J. 2018 Feb;285(3):501-517. doi: 10.1111/febs.14349. Epub 2017 Dec 26.
Additional References at PubMed
PMID:7739539   PMID:8336713   PMID:9329978   PMID:11739104   PMID:11829742   PMID:12016216   PMID:12031952   PMID:12031958   PMID:12202038   PMID:12242332   PMID:12488438   PMID:12600983  
PMID:12764144   PMID:12771318   PMID:12865412   PMID:12941932   PMID:14505487   PMID:14654692   PMID:14668913   PMID:14674713   PMID:14744869   PMID:14988441   PMID:15001432   PMID:15037635  
PMID:15039461   PMID:15123649   PMID:15123720   PMID:15249218   PMID:15266058   PMID:15280151   PMID:15281019   PMID:15330762   PMID:15358760   PMID:15561928   PMID:15637161   PMID:15896314  
PMID:16002205   PMID:16046411   PMID:16091421   PMID:16092054   PMID:16100574   PMID:16380121   PMID:16554040   PMID:16772326   PMID:16787385   PMID:16834571   PMID:16890542   PMID:17074803  
PMID:17296605   PMID:17313375   PMID:17449871   PMID:17456898   PMID:17632011   PMID:17636037   PMID:18060044   PMID:18157544   PMID:18178930   PMID:18635549   PMID:18665039   PMID:18989661  
PMID:19125418   PMID:19244231   PMID:19299314   PMID:19366697   PMID:19375767   PMID:19564420   PMID:19616615   PMID:19672729   PMID:19682972   PMID:19716432   PMID:19786558   PMID:19966780  
PMID:20005944   PMID:20041157   PMID:20211032   PMID:20589757   PMID:20615871   PMID:21036148   PMID:21038676   PMID:21167679   PMID:21459323   PMID:21540177   PMID:21652712   PMID:21731709  
PMID:21757781   PMID:21906525   PMID:21986124   PMID:22031849   PMID:22093779   PMID:22292946   PMID:22331133   PMID:22415588   PMID:22511764   PMID:22645024   PMID:22898567   PMID:23028851  
PMID:23065593   PMID:23106379   PMID:23239524   PMID:23257266   PMID:23295202   PMID:23542164   PMID:23583293   PMID:23610160   PMID:23823476   PMID:23913732   PMID:24296663   PMID:24362725  
PMID:24425205   PMID:24625548   PMID:24912190   PMID:25046614   PMID:25348957   PMID:25398788   PMID:25616173   PMID:25796423   PMID:25847140   PMID:26218603   PMID:26327595   PMID:26437365  
PMID:26449613   PMID:26589965   PMID:27321819   PMID:27352290   PMID:27382175   PMID:27614840   PMID:27826032   PMID:28027934   PMID:28264426   PMID:28465347   PMID:28719803   PMID:29366380  
PMID:29627845   PMID:29735017   PMID:29952285   PMID:30998947   PMID:31541353   PMID:31677037   PMID:32332706   PMID:34655015   PMID:34923569   PMID:38079167   PMID:38369486  


Genomics

Comparative Map Data
Srebf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,507,152 - 45,529,164 (-)NCBIGRCr8
mRatBN7.21045,007,637 - 45,029,650 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,007,637 - 45,029,650 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,707,833 - 49,729,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01049,198,201 - 49,220,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,701,803 - 44,723,821 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,570,996 - 46,593,021 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,570,996 - 46,593,009 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,326,015 - 46,348,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,461,684 - 46,483,646 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1044,264,866 - 44,286,830 (-)NCBICelera
Cytogenetic Map10q22NCBI
SREBF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381717,811,334 - 17,836,986 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1717,810,399 - 17,837,002 (-)EnsemblGRCh38hg38GRCh38
GRCh371717,714,648 - 17,740,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,656,111 - 17,681,050 (-)NCBINCBI36Build 36hg18NCBI36
Build 341717,656,110 - 17,681,050NCBI
Celera1718,654,135 - 18,680,982 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1717,466,908 - 17,494,061 (-)NCBIHuRef
CHM1_11717,723,458 - 17,749,109 (-)NCBICHM1_1
T2T-CHM13v2.01717,757,927 - 17,783,669 (-)NCBIT2T-CHM13v2.0
Srebf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,089,910 - 60,113,407 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,089,915 - 60,113,407 (-)EnsemblGRCm39 Ensembl
GRCm381160,199,084 - 60,224,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,199,089 - 60,222,581 (-)EnsemblGRCm38mm10GRCm38
MGSCv371160,012,591 - 60,034,106 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,015,284 - 60,036,799 (-)NCBIMGSCv36mm8
Celera1166,655,030 - 66,676,425 (+)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1137.81NCBI
Srebf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577171,425 - 186,046 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955577171,425 - 183,669 (+)NCBIChiLan1.0ChiLan1.0
SREBF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21952,328,005 - 52,355,769 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11757,040,217 - 57,065,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01733,458,196 - 33,484,643 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11738,405,794 - 38,432,045 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,405,794 - 38,432,045 (+)Ensemblpanpan1.1panPan2
SREBF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,663,809 - 41,686,764 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,663,773 - 41,686,776 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,802,335 - 41,825,236 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0541,769,693 - 41,792,654 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl541,769,687 - 41,925,702 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1541,737,352 - 41,760,245 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,684,736 - 41,707,631 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,876,687 - 41,899,587 (+)NCBIUU_Cfam_GSD_1.0
Srebf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,447,521 - 61,458,579 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367411,406,521 - 1,419,776 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367411,408,669 - 1,419,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SREBF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,733,907 - 60,751,267 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,733,967 - 60,750,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SREBF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11616,847,603 - 16,874,239 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1616,845,491 - 16,859,554 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660594,037,449 - 4,063,735 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srebf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248493,602,261 - 3,623,465 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248493,602,103 - 3,623,922 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Srebf1
112 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:43
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000004753, ENSRNOT00000047053
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat

Markers in Region
PMC134715P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21045,014,834 - 45,014,914 (+)MAPPERmRatBN7.2
Rnor_6.01046,578,194 - 46,578,273NCBIRnor6.0
Rnor_5.01046,333,213 - 46,333,292UniSTSRnor5.0
RGSC_v3.41046,468,873 - 46,468,952UniSTSRGSC3.4
Celera1044,272,064 - 44,272,143UniSTS
Cytogenetic Map10q22UniSTS
RH132247  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21045,007,766 - 45,007,976 (+)MAPPERmRatBN7.2
Rnor_6.01046,571,126 - 46,571,335NCBIRnor6.0
Rnor_5.01046,326,145 - 46,326,354UniSTSRnor5.0
RGSC_v3.41046,461,805 - 46,462,014UniSTSRGSC3.4
Celera1044,264,996 - 44,265,205UniSTS
RH 3.4 Map10524.79UniSTS
Cytogenetic Map10q22UniSTS


Related Rat Strains
The following Strains have been annotated to Srebf1
SHR.BN-(D10Mgh3-Srebf1)/Ipcv    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 14 57 41 19 41 8 11 74 35 36 11 8
Low 29 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004753   ⟹   ENSRNOP00000004753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1045,007,637 - 45,019,495 (-)Ensembl
Rnor_6.0 Ensembl1046,570,996 - 46,582,854 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000047053   ⟹   ENSRNOP00000050057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1045,007,637 - 45,029,650 (-)Ensembl
Rnor_6.0 Ensembl1046,570,996 - 46,593,009 (-)Ensembl
RefSeq Acc Id: NM_001276707   ⟹   NP_001263636
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,507,152 - 45,529,164 (-)NCBI
mRatBN7.21045,007,637 - 45,029,650 (-)NCBI
Rnor_6.01046,570,996 - 46,593,009 (-)NCBI
Rnor_5.01046,326,015 - 46,348,035 (-)NCBI
Celera1044,264,866 - 44,286,830 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001276708   ⟹   NP_001263637
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,507,152 - 45,519,010 (-)NCBI
mRatBN7.21045,007,637 - 45,019,495 (-)NCBI
Rnor_6.01046,570,996 - 46,582,854 (-)NCBI
Rnor_5.01046,326,015 - 46,348,035 (-)NCBI
Celera1044,264,866 - 44,276,706 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063269911   ⟹   XP_063125981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,508,552 - 45,529,163 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001263636   ⟸   NM_001276707
- Peptide Label: isoform 1 precursor
- UniProtKB: Q99PI6 (UniProtKB/Swiss-Prot),   Q99PI7 (UniProtKB/Swiss-Prot),   P56720 (UniProtKB/Swiss-Prot),   A6HF27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263637   ⟸   NM_001276708
- Peptide Label: isoform 2
- UniProtKB: A6HF28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004753   ⟸   ENSRNOT00000004753
RefSeq Acc Id: ENSRNOP00000050057   ⟸   ENSRNOT00000047053
RefSeq Acc Id: XP_063125981   ⟸   XM_063269911
- Peptide Label: isoform X1
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56720-F1-model_v2 AlphaFold P56720 1-1134 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697246
Promoter ID:EPDNEW_R7770
Type:multiple initiation site
Name:Srebf1_2
Description:sterol regulatory element binding transcription factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7771  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01046,582,882 - 46,582,942EPDNEW
RGD ID:13697247
Promoter ID:EPDNEW_R7771
Type:initiation region
Name:Srebf1_1
Description:sterol regulatory element binding transcription factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7770  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01046,593,003 - 46,593,063EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69423 AgrOrtholog
BioCyc Gene G2FUF-24862 BioCyc
Ensembl Genes ENSRNOG00000003463 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004753 ENTREZGENE
  ENSRNOT00000004753.6 UniProtKB/Swiss-Prot
  ENSRNOT00000047053 ENTREZGENE
  ENSRNOT00000047053.7 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:78968 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 78968 ENTREZGENE
PANTHER STEROL REGULATORY ELEMENT-BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STEROL REGULATORY ELEMENT-BINDING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Srebf1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003463 RatGTEx
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP HLH, helix-loop-helix DNA-binding domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC217415
UniProt A6HF27 ENTREZGENE, UniProtKB/TrEMBL
  A6HF28 ENTREZGENE, UniProtKB/TrEMBL
  P56720 ENTREZGENE
  Q99PI6 ENTREZGENE
  Q99PI7 ENTREZGENE
  SRBP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q99PI6 UniProtKB/Swiss-Prot
  Q99PI7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-11 Srebf1  sterol regulatory element binding transcription factor 1  Srebf1  sterol regulatory element binding factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Srebf1  sterol regulatory element binding factor 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization precursor form localizes to the endoplasmic reticulum and nuclear envelope and mature form localizes to the nucleus 625517
gene_disease may play a role in streptozotocin-induced diabetes based on observed increase in renal expression 625517
gene_process enhances transcription of genes encoding enzymes of unsaturated fatty acid biosynthesis 68688
gene_process enhances transcription of genes encoding enzymes of unsaturated fatty acid biosynthesis 68702
gene_process enhances transcription of genes encoding enzymes of unsaturated fatty acid biosynthesis 625517
gene_process regulates genes involved in fatty acid and triglyceride metabolism 68688
gene_process regulates genes involved in fatty acid and triglyceride metabolism 68702
gene_process regulates genes involved in fatty acid and triglyceride metabolism 625517
gene_process mediates increased lipid synthesis, triglyceride accumulation, mesangial expansion, glomerulosclerosis, and proteinuria through increasing the expression of transforming growth factor and vascular endothelial growth factor 625517
gene_product member of the basic helix-loop-helix-leucine zipper family 625517
gene_product active protein contains 500 amino acids 625517
gene_transcript two splice variants have been identified 625517