Annotation (Toggle Detail/Summary View) Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1605434 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HES1 mRNA | CTD | PMID:22079256 | 17beta-estradiol | decreases expression | ISO | RGD:1605434 | 6480464 | Estradiol results in decreased expression of HES1 mRNA | CTD | PMID:23019147 | 17beta-estradiol | decreases expression | ISO | RGD:1605434 | 6480464 | Estradiol results in decreased expression of HES1 mRNA | CTD | PMID:19167446 PMID:23019147 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1605434 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HES1 mRNA | CTD | PMID:16697128 more ... | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:62373 | 6480464 | Tetrachlorodibenzodioxin affects the expression of HES1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1605434 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HES1 mRNA | CTD | PMID:14722248 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HES1 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:62373 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HES1 mRNA | CTD | PMID:19770486 PMID:21889950 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:62373 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HES1 promoter] | CTD | PMID:21889950 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1605434 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HES1 mRNA | CTD | PMID:14722248 more ... | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1605434 | 6480464 | Tetrachlorodibenzodioxin affects the expression of HES1 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1605434 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HES1 mRNA | CTD | PMID:20106945 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:62373 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HES1 mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1605434 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HES1 mRNA | CTD | PMID:14722248 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1605434 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HES1 protein | CTD | PMID:14722248 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of HES1 mRNA | CTD | PMID:21346803 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | RGD:62373 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HES1 mRNA | CTD | PMID:20188158 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in decreased expression of HES1 mRNA | CTD | PMID:19162173 | 4-hydroperoxycyclophosphamide | increases expression | ISO | RGD:62373 | 6480464 | perfosfamide results in increased expression of HES1 mRNA | CTD | PMID:19429390 | 5-fluorouracil | increases activity | ISO | RGD:1605434 | 6480464 | Fluorouracil results in increased activity of HES1 protein | CTD | PMID:19147571 | acetaldehyde | increases expression | ISO | RGD:1605434 | 6480464 | Acetaldehyde results in increased expression of HES1 mRNA | CTD | PMID:23416264 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of HES1 mRNA | CTD | PMID:16483693 | arsenite(3-) | decreases expression | ISO | RGD:1605434 | 6480464 | arsenite results in decreased expression of HES1 mRNA; more ... | CTD | PMID:18633435 | arsenite(3-) | multiple interactions | ISO | RGD:1605434 | 6480464 | tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of HES1 mRNA] | CTD | PMID:18633435 | baicalein | multiple interactions | ISO | RGD:1605434 | 6480464 | N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HES1 mRNA] | CTD | PMID:19160421 | baicalein | increases expression | ISO | RGD:1605434 | 6480464 | baicalein results in increased expression of HES1 mRNA | CTD | PMID:19160421 | baicalin | increases expression | ISO | RGD:1605434 | 6480464 | baicalin results in increased expression of HES1 mRNA | CTD | PMID:19160421 | baicalin | multiple interactions | ISO | RGD:1605434 | 6480464 | N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA] | CTD | PMID:19160421 | benzene-1,2,4-triol | increases expression | ISO | RGD:1605434 | 6480464 | hydroxyhydroquinone results in increased expression of HES1 mRNA | CTD | PMID:17572062 | benzo[a]pyrene | increases expression | ISO | RGD:1605434 | 6480464 | Benzo(a)pyrene results in increased expression of HES1 mRNA | CTD | PMID:20064835 PMID:20106945 | benzo[a]pyrene | increases expression | ISO | RGD:1605434 | 6480464 | Benzo(a)pyrene results in increased expression of HES1 mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene | increases expression | ISO | RGD:1605434 | 6480464 | Benzo(a)pyrene results in increased expression of HES1 mRNA | CTD | PMID:21871943 more ... | benzo[a]pyrene | increases expression | ISO | RGD:1605434 | 6480464 | Benzo(a)pyrene results in increased expression of HES1 mRNA | CTD | PMID:20106945 more ... | bisphenol A | increases expression | ISO | RGD:62373 | 6480464 | bisphenol A results in increased expression of HES1 mRNA | CTD | PMID:16902998 | calcitriol | increases expression | ISO | RGD:1605434 | 6480464 | Calcitriol results in increased expression of HES1 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | RGD:1605434 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of HES1 mRNA | CTD | PMID:21592394 | calcium atom | affects expression | EXP | | 6480464 | Calcium affects the expression of HES1 mRNA | CTD | PMID:15913539 | calcium(0) | affects expression | EXP | | 6480464 | Calcium affects the expression of HES1 mRNA | CTD | PMID:15913539 | carbonyl sulfide | increases expression | EXP | | 6480464 | carbonyl sulfide results in increased expression of HES1 mRNA | CTD | PMID:19395590 | choline | multiple interactions | ISO | RGD:62373 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HES1 mRNA | CTD | PMID:20938992 | clofibrate | decreases expression | ISO | RGD:62373 | 6480464 | Clofibrate results in decreased expression of HES1 mRNA | CTD | PMID:17585979 | copper(2+) sulfate | increases expression | ISO | RGD:1605434 | 6480464 | Copper Sulfate results in increased expression of HES1 mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | RGD:1605434 | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of HES1 mRNA | CTD | PMID:19167446 | curcumin | multiple interactions | ISO | RGD:62373 | 6480464 | [1,2-Dimethylhydrazine co-treated with Curcumin] results in increased expression of HES1 mRNA | CTD | PMID:22982865 | dexamethasone | decreases expression | ISO | RGD:1605434 | 6480464 | Dexamethasone results in decreased expression of HES1 mRNA | CTD | PMID:12782123 | diarsenic trioxide | decreases expression | ISO | RGD:1605434 | 6480464 | arsenic trioxide results in decreased expression of HES1 mRNA | CTD | PMID:20458559 | diazoxide | decreases expression | ISO | RGD:62373 | 6480464 | Isoproterenol results in decreased expression of HES1 mRNA | CTD | PMID:20003209 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of HES1 mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of HES1 mRNA | CTD | PMID:21266533 | diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of HES1 mRNA | CTD | PMID:21658437 | elemental selenium | decreases expression | ISO | RGD:1605434 | 6480464 | Selenium results in decreased expression of HES1 mRNA | CTD | PMID:19244175 | elemental selenium | multiple interactions | ISO | RGD:1605434 | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of HES1 mRNA | CTD | PMID:19244175 | fluoxetine | increases expression | EXP | | 6480464 | Fluoxetine results in increased expression of HES1 protein; more ... | CTD | PMID:19801843 | folic acid | multiple interactions | ISO | RGD:62373 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HES1 mRNA | CTD | PMID:20938992 | formaldehyde | increases expression | ISO | RGD:1605434 | 6480464 | Formaldehyde results in increased expression of HES1 mRNA | CTD | PMID:17938736 | genistein | decreases expression | ISO | RGD:1605434 | 6480464 | Genistein results in decreased expression of HES1 mRNA | CTD | PMID:23019147 | hydrogen peroxide | affects expression | ISO | RGD:1605434 | 6480464 | Hydrogen Peroxide affects the expression of HES1 mRNA | CTD | PMID:20044591 | isoprenaline | decreases expression | ISO | RGD:62373 | 6480464 | Isoproterenol results in decreased expression of HES1 mRNA | CTD | PMID:20003209 | L-methionine | multiple interactions | ISO | RGD:62373 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HES1 mRNA | CTD | PMID:20938992 | menadione | affects expression | ISO | RGD:1605434 | 6480464 | Vitamin K 3 affects the expression of HES1 mRNA | CTD | PMID:20044591 | methotrexate | affects expression | ISO | RGD:62373 | 6480464 | Methotrexate affects the expression of HES1 mRNA | CTD | PMID:18502557 | methylmercury chloride | affects expression | EXP | | 6480464 | methylmercuric chloride affects the expression of HES1 mRNA | CTD | PMID:20864626 | ochratoxin A | decreases expression | EXP | | 6480464 | ochratoxin A results in decreased expression of HES1 mRNA | CTD | PMID:21703336 | oxaliplatin | increases activity | ISO | RGD:1605434 | 6480464 | oxaliplatin results in increased activity of HES1 protein | CTD | PMID:19147571 | oxaliplatin | increases expression | ISO | RGD:1605434 | 6480464 | oxaliplatin results in increased expression of HES1 protein | CTD | PMID:19147571 | paracetamol | affects expression | ISO | RGD:62373 | 6480464 | Acetaminophen affects the expression of HES1 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:1605434 | 6480464 | Acetaminophen results in increased expression of HES1 mRNA | CTD | PMID:22230336 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of HES1 mRNA | CTD | PMID:19162173 | phenol | increases expression | ISO | RGD:1605434 | 6480464 | Phenol results in increased expression of HES1 mRNA | CTD | PMID:17547211 | pirinixic acid | multiple interactions | ISO | RGD:62373 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HES1 mRNA | CTD | PMID:19710929 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of HES1 mRNA | CTD | PMID:19162173 | propiconazole | decreases expression | ISO | RGD:62373 | 6480464 | propiconazole results in decreased expression of HES1 mRNA | CTD | PMID:21278054 | quercetin | increases expression | ISO | RGD:1605434 | 6480464 | Quercetin results in increased expression of HES1 mRNA | CTD | PMID:21632981 | resveratrol | decreases expression | ISO | RGD:1605434 | 6480464 | resveratrol results in decreased expression of HES1 mRNA | CTD | PMID:17868649 | retinyl acetate | increases expression | ISO | RGD:62373 | 6480464 | retinol acetate results in increased expression of HES1 mRNA | CTD | PMID:16772331 | selenium atom | decreases expression | ISO | RGD:1605434 | 6480464 | Selenium results in decreased expression of HES1 mRNA | CTD | PMID:19244175 | selenium atom | multiple interactions | ISO | RGD:1605434 | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of HES1 mRNA | CTD | PMID:19244175 | sirolimus | decreases expression | ISO | RGD:1605434 | 6480464 | Sirolimus results in decreased expression of HES1 protein | CTD | PMID:20038814 | sirolimus | decreases expression | ISO | RGD:62373 | 6480464 | Sirolimus results in decreased expression of HES1 protein; more ... | CTD | PMID:20038814 | tert-butyl hydroperoxide | increases expression | ISO | RGD:1605434 | 6480464 | tert-Butylhydroperoxide results in increased expression of HES1 mRNA | CTD | PMID:15336504 | testosterone | multiple interactions | ISO | RGD:1605434 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of HES1 mRNA | CTD | PMID:21592394 | testosterone | increases expression | ISO | RGD:1605434 | 6480464 | Testosterone results in increased expression of HES1 mRNA | CTD | PMID:21592394 | trans-resveratrol | decreases expression | ISO | RGD:1605434 | 6480464 | resveratrol results in decreased expression of HES1 mRNA | CTD | PMID:17868649 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsBiological Process











