Gene: Fn1 (fibronectin 1)  Rattus norvegicus Symbol: Fn1 Name: fibronectin 1 Description: ENCODES a protein that exhibits mercury ion binding; protease binding; peptidase activator activity (ortholog); INVOLVED IN cell activation; cell-matrix adhesion; cellular response to BMP stimulus; PARTICIPATES IN syndecan signaling pathway; cell-extracellular matrix signaling pathway; Entamoeba histolyca infection pathway; ASSOCIATED WITH Acute Kidney Injury; Diabetes Mellitus, Experimental; Diabetic Angiopathies; FOUND IN basement membrane; extracellular space; apical plasma membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2,2-tetramine Type: protein-coding RefSeq Status: VALIDATED Also known as: FIBNEC; fibronectin; FN; fn-1 Orthologs: Homo sapiens : FN1 (fibronectin 1)  HGNC Mus musculus : Fn1 (fibronectin 1)  MGI Latest Assembly: RGSC Genome Assembly v3.4 Position: Map Chr Position Strand Source Rat Cytogenetic Map 9 q33   NCBI RGSC Genome Assembly v5.0 9 78,674,439 - 78,743,407 - NCBI RGSC Genome Assembly v3.4 9 70,702,181 - 70,771,155 - NCBI Rat Celera Assembly 9 70,607,233 - 70,675,716 - NCBI Genome Assembly 3.1 9 70,849,162 - 70,918,137 - NCBI RH 3.4 9 673.9   RGD Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Acute Kidney Injury   IEP   729934 protein:increased expression:kidney RGD   Acute Kidney Injury   IEP   7205684   RGD   Carcinoma, Renal Cell Severity ISS RGD:736627 7205637   RGD   Diabetes Mellitus   ISS RGD:736627 7206845 protein:increased expression:plasma RGD   Diabetes Mellitus, Experimental   IEP   7206838 protein:increased expression:kidney RGD   Diabetic Angiopathies   IED   1601179   RGD   Diabetic Nephropathies   ISS RGD:10594 7206843 associated with Diabetes Mellitus, Experimental; more ... RGD   Glomerulonephritis Disease_progression ISS RGD:736627 7206839   RGD   Glomerulonephritis, IGA   ISS RGD:736627 7206844 protein:increased expression:kidney RGD   Glomerulonephritis, Membranoproliferative   IEP   7206847   RGD   Glomerulopathy with fibronectin deposits   ISS RGD:736627 7240710   OMIM   Hypertension, Renovascular   IED   7205461   RGD   Kidney Failure, Chronic   ISS RGD:736627 7205701 protein:decreased expression:plasma RGD   Kidney Reperfusion Injury   IEP   7205629   RGD   Liver Injury   IEP   7205469   RGD   Liver Reperfusion Injury   IED   7205470   RGD   Myocardial Infarction   IEP   2325720 protein:decreased expression:heart RGD   Nephrolithiasis   IEP   7206846 protein:increased expression:kidney RGD   Nephrolithiasis   ISS RGD:736627 7206842 DNA:polymorphism: : RGD   Pneumonia, Staphylococcal   IED   7205474   RGD   Spinal Cord Injuries   ISS RGD:736627 7205459   RGD   Sturge-Weber Syndrome   ISS   1358624   RGD   Submandibular Gland Diseases   IEP   7205460   RGD   Ureteral Obstruction   IEP   7205473   RGD   Urinary Bladder Neoplasms   ISS RGD:736627 7205680 protein:increased expression:urine RGD   VATER association   IEP   7205466 protein:increased expression:embryo RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (R)-noradrenaline multiple interactions ISO RGD:736627 6480464 [Norepinephrine co-treated with Prazosin] results in decreased expression of FN1 protein; more ... CTD PMID:11821714 (S)-nicotine decreases expression ISO RGD:736627 6480464 Nicotine results in decreased expression of FN1 mRNA CTD PMID:18247414 (S)-nicotine increases expression ISO RGD:736627 6480464 Nicotine results in increased expression of FN1 protein CTD PMID:18844224 17alpha-ethynylestradiol multiple interactions ISO RGD:736627 6480464 [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of FN1 protein CTD PMID:15504374 17alpha-ethynylestradiol increases expression EXP   6480464 Ethinyl Estradiol results in increased expression of FN1 mRNA CTD PMID:12655037 more ... 17alpha-ethynylestradiol increases expression EXP   6480464 Ethinyl Estradiol results in increased expression of FN1 mRNA CTD PMID:16140622 more ... 17alpha-ethynylestradiol increases expression EXP   6480464 Ethinyl Estradiol results in increased expression of FN1 mRNA CTD PMID:12655037 more ... 17alpha-ethynylestradiol increases expression EXP   6480464 Ethinyl Estradiol results in increased expression of FN1 mRNA CTD PMID:16140622 more ... 17alpha-ethynylestradiol affects expression EXP   6480464 Ethinyl Estradiol affects the expression of FN1 mRNA CTD PMID:16551644 17alpha-ethynylestradiol multiple interactions ISO RGD:10594 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FN1 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:736627 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FN1 mRNA CTD PMID:19619570 17beta-estradiol decreases expression ISO RGD:736627 6480464 Estradiol results in decreased expression of FN1 mRNA CTD PMID:19619570 2,2',4,4',5,5'-hexachlorobiphenyl decreases expression EXP   6480464 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of FN1 mRNA CTD PMID:20959002 2,2,2-tetramine multiple interactions EXP   6480464 Trientine inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA] CTD PMID:16973718 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736627 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FN1 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10594 6480464 Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA CTD PMID:19770486 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736627 6480464 Tetrachlorodibenzodioxin results in increased expression of FN1 protein CTD PMID:16083274 PMID:22902829 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10594 6480464 tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA] CTD PMID:22749964 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP   6480464 Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA CTD PMID:18178546 PMID:20959002 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:736627 6480464 Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA CTD PMID:21296121 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10594 6480464 Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA CTD PMID:19770486 PMID:19933214 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:736627 6480464 Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA CTD PMID:19619570 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10594 6480464 Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA CTD PMID:19933214 PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:736627 6480464 Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA CTD PMID:19619570 PMID:19901195 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP   6480464 Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA CTD PMID:18178546 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10594 6480464 Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA CTD PMID:19933214 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10594 6480464 Tetrachlorodibenzodioxin results in increased expression of FN1 mRNA CTD PMID:16114106 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10594 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FN1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736627 6480464 Tetrachlorodibenzodioxin results in increased expression of FN1 protein CTD PMID:16083274 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:736627 6480464 Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA CTD PMID:19901195 PMID:19619570 2,3-dimethoxynaphthalene-1,4-dione multiple interactions EXP   6480464 2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of and results in decreased secretion of FN1 protein CTD PMID:19524604 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO RGD:10594 6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FN1 mRNA] CTD PMID:18200517 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:10594 6480464 Trinitrobenzenesulfonic Acid results in increased expression of FN1 mRNA CTD PMID:18200517 2,4-dinitrotoluene affects expression EXP   6480464 2,4-dinitrotoluene affects the expression of FN1 mRNA CTD PMID:21346803 2-acetamidofluorene increases expression EXP   6480464 2-Acetylaminofluorene results in increased expression of FN1 mRNA CTD PMID:15940639 2-amino-2-deoxy-D-glucopyranose decreases expression ISO RGD:10594 6480464 Glucosamine results in decreased expression of FN1 protein CTD PMID:17178593 2-amino-2-deoxy-D-glucopyranose decreases expression EXP   6480464 Glucosamine results in decreased expression of FN1 protein CTD PMID:17178593 2-naphthylamine decreases expression ISO RGD:736627 6480464 2-Naphthylamine results in decreased expression of FN1 mRNA CTD PMID:18247414 2-nitrofluorene decreases expression EXP   6480464 2-nitrofluorene results in decreased expression of FN1 mRNA CTD PMID:15890375 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression EXP   6480464 Puromycin Aminonucleoside results in increased expression of FN1 mRNA CTD PMID:9527400 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine multiple interactions EXP   6480464 Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FN1 protein] CTD PMID:12813006 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression EXP   6480464 Puromycin Aminonucleoside results in increased expression of FN1 protein CTD PMID:12813006 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO RGD:736627 6480464 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FN1 mRNA CTD PMID:23146750 4,4'-diaminodiphenylmethane decreases expression EXP   6480464 4,4'-diaminodiphenylmethane results in decreased expression of FN1 mRNA CTD PMID:18289764 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one decreases expression EXP   6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of FN1 mRNA CTD PMID:15890375 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid increases expression ISO RGD:736627 6480464 Am 580 results in increased expression of FN1 mRNA CTD PMID:16982809 5-(2-methylpiperazine-1-sulfonyl)isoquinoline multiple interactions EXP   6480464 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] CTD PMID:7945571 5-fluorouracil decreases expression ISO RGD:10594 6480464 Fluorouracil results in decreased expression of FN1 protein CTD PMID:21296659 7,12-dimethyltetraphene multiple interactions EXP   6480464 [9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of FN1 protein CTD PMID:22248470 7,12-dimethyltetraphene decreases expression EXP   6480464 9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FN1 mRNA CTD PMID:12376462 8-bromo-3',5'-cyclic AMP decreases expression ISO RGD:736627 6480464 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of FN1 mRNA CTD PMID:22079614 9-cis-retinoic acid decreases expression ISO RGD:736627 6480464 alitretinoin results in decreased expression of FN1 protein; more ... CTD PMID:11139446 9-cis-retinoic acid increases expression EXP   6480464 alitretinoin results in increased expression of FN1 mRNA CTD PMID:16648578 acetaldehyde multiple interactions ISO RGD:736627 6480464 calphostin C inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA]; more ... CTD PMID:11343241 acetaldehyde increases expression EXP   6480464 Acetaldehyde results in increased expression of FN1 mRNA CTD PMID:7945571 PMID:8151099 acetaldehyde increases expression ISO RGD:736627 6480464 Acetaldehyde results in increased expression of FN1 mRNA CTD PMID:11343241 PMID:8135774 acetaldehyde increases expression EXP   6480464 Acetaldehyde results in increased expression of FN1 protein CTD PMID:14724836 acetaldehyde increases expression EXP   6480464 Acetaldehyde results in increased expression of FN1 mRNA CTD PMID:8151099 PMID:7945571 acetaldehyde multiple interactions EXP   6480464 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA]; more ... CTD PMID:7945571 acetaldehyde multiple interactions EXP   6480464 4-hydroxymercuribenzoate inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA]; more ... CTD PMID:8151099 acetaldehyde multiple interactions ISO RGD:736627 6480464 TGFB1 protein promotes the reaction [Acetaldehyde results in increased expression of FN1 protein] CTD PMID:8135774 acetaldehyde increases expression ISO RGD:736627 6480464 Acetaldehyde results in increased expression of FN1 protein CTD PMID:8135774 acetaldehyde increases expression ISO RGD:736627 6480464 Acetaldehyde results in increased expression of FN1 mRNA CTD PMID:8135774 PMID:11343241 acetylsalicylic acid multiple interactions EXP   6480464 Aspirin inhibits the reaction [Streptozocin results in increased expression of FN1] CTD PMID:14586741 actinomycin D multiple interactions ISO RGD:736627 6480464 Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of FN1 mRNA] CTD PMID:18253093 afimoxifene decreases expression ISO RGD:736627 6480464 4-hydroxytamoxifen results in decreased expression of FN1 mRNA CTD PMID:19901195 aflatoxin B1 decreases expression EXP   6480464 Aflatoxin B1 results in decreased expression of FN1 mRNA CTD PMID:15890375 aldehydo-D-glucosamine decreases expression ISO RGD:10594 6480464 Glucosamine results in decreased expression of FN1 protein CTD PMID:17178593 aldehydo-D-glucosamine decreases expression EXP   6480464 Glucosamine results in decreased expression of FN1 protein CTD PMID:17178593 all-trans-retinoic acid multiple interactions ISO RGD:736627 6480464 [Tretinoin co-treated with Ascorbic Acid] results in increased expression of FN1 mRNA CTD PMID:16443354 all-trans-retinoic acid increases expression ISO RGD:736627 6480464 Tretinoin results in increased expression of FN1 mRNA CTD PMID:21934132 PMID:17138961 all-trans-retinoic acid increases expression ISO RGD:736627 6480464 Tretinoin results in increased expression of FN1 mRNA CTD PMID:17138961 PMID:21934132 all-trans-retinoic acid multiple interactions EXP   6480464 Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FN1 protein] CTD PMID:12813006 all-trans-retinoic acid increases expression ISO RGD:736627 6480464 Tretinoin results in increased expression of FN1 mRNA CTD PMID:17138961 all-trans-retinol decreases secretion ISO RGD:736627 6480464 Vitamin A results in decreased secretion of FN1 protein CTD PMID:17225872 alpha-hexachlorocyclohexane increases expression EXP   6480464 alpha-hexachlorocyclohexane results in increased expression of FN1 mRNA CTD PMID:17785943 aluminium oxide increases expression ISO RGD:736627 6480464 Aluminum Oxide results in increased expression of FN1 mRNA CTD PMID:19464052 ammonium chloride affects expression EXP   6480464 Ammonium Chloride affects the expression of FN1 mRNA CTD PMID:16483693 ammonium chloride decreases expression EXP   6480464 Ammonium Chloride results in decreased expression of FN1 protein CTD PMID:16483693 apocynin multiple interactions EXP   6480464 acetovanillone inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:22245600 apocynin multiple interactions ISO RGD:736627 6480464 acetovanillone inhibits the reaction [Glucose results in increased secretion of FN1 protein] CTD PMID:15086456 arsenite(3-) decreases expression ISO RGD:10594 6480464 arsenite results in decreased expression of FN1 mRNA CTD PMID:18191166 asbestos increases expression ISO RGD:736627 6480464 Asbestos results in increased expression of FN1 mRNA CTD PMID:22398240 bacitracin increases expression EXP   6480464 Bacitracin results in increased expression of FN1 mRNA CTD PMID:18289764 benazepril decreases expression EXP   6480464 benazepril results in decreased expression of FN1 mRNA; more ... CTD PMID:16191423 benazepril multiple interactions EXP   6480464 benazepril inhibits the reaction [Doxorubicin results in increased expression of FN1 protein] CTD PMID:10515446 benazepril multiple interactions EXP   6480464 benazepril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA] CTD PMID:11798618 benzo[a]pyrene decreases expression ISO RGD:10594 6480464 Benzo(a)pyrene results in decreased expression of FN1 mRNA CTD PMID:19770486 benzo[a]pyrene decreases expression ISO RGD:736627 6480464 Benzo(a)pyrene results in decreased expression of FN1 mRNA CTD PMID:18247414 PMID:20064835 benzo[a]pyrene decreases expression ISO RGD:736627 6480464 Benzo(a)pyrene results in decreased expression of FN1 mRNA CTD PMID:20064835 PMID:18247414 beta-D-glucosamine decreases expression ISO RGD:10594 6480464 Glucosamine results in decreased expression of FN1 protein CTD PMID:17178593 beta-D-glucosamine decreases expression EXP   6480464 Glucosamine results in decreased expression of FN1 protein CTD PMID:17178593 bezafibrate multiple interactions EXP   6480464 Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA] CTD PMID:18513333 bis(2-chloroethyl) sulfide decreases expression ISO RGD:736627 6480464 Mustard Gas results in decreased expression of FN1 protein CTD PMID:9665388 PMID:11428642 bis(2-chloroethyl) sulfide decreases expression ISO RGD:736627 6480464 Mustard Gas results in decreased expression of FN1 protein CTD PMID:11428642 PMID:9665388 bis(2-chloroethyl) sulfide decreases expression ISO RGD:10594 6480464 Mustard Gas results in decreased expression of FN1 mRNA CTD PMID:15674843 bis(2-chloroethyl) sulfide increases alkylation ISO RGD:736627 6480464 Mustard Gas results in increased alkylation of FN1 protein CTD PMID:18342354 bisphenol A increases expression ISO RGD:736627 6480464 bisphenol A results in increased expression of FN1 mRNA CTD PMID:22576693 bosentan multiple interactions ISO RGD:736627 6480464 bosentan inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; more ... CTD PMID:12388107 bromobenzene decreases expression EXP   6480464 bromobenzene results in decreased expression of FN1 mRNA CTD PMID:12628495 bromochloroacetic acid increases expression ISO RGD:10594 6480464 bromochloroacetic acid results in increased expression of FN1 protein CTD PMID:21296659 cadmium dichloride increases expression ISO RGD:10594 6480464 Cadmium Chloride results in increased expression of FN1 mRNA CTD PMID:20478370 cadmium selenide multiple interactions ISO RGD:736627 6480464 [cadmium selenide co-treated with zinc sulfide] results in increased expression of FN1 mRNA CTD PMID:22342292 carbonyl sulfide increases expression EXP   6480464 carbonyl sulfide results in increased expression of FN1 mRNA CTD PMID:19395590 carvedilol multiple interactions EXP   6480464 carvedilol inhibits the reaction [[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of FN1 mRNA] CTD PMID:11682445 carvedilol multiple interactions EXP   6480464 carvedilol inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:12140129 carvedilol decreases expression EXP   6480464 carvedilol results in decreased expression of FN1 protein CTD PMID:11181017 chloroprene decreases expression ISO RGD:10594 6480464 Chloroprene results in decreased expression of FN1 mRNA CTD PMID:23125180 cisplatin increases activity ISO RGD:736627 6480464 FN1 protein results in increased activity of Cisplatin CTD PMID:21567080 cisplatin increases expression EXP   6480464 Cisplatin results in increased expression of FN1 mRNA CTD PMID:18289764 clofibrate decreases expression EXP   6480464 Clofibrate results in decreased expression of FN1 mRNA CTD PMID:12851107 clofibric acid multiple interactions EXP   6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of FN1 mRNA CTD PMID:17602206 cobalt atom multiple interactions ISO RGD:736627 6480464 [tungsten carbide binds to Cobalt] which results in increased expression of FN1 mRNA CTD PMID:20105288 cobalt dichloride increases expression ISO RGD:736627 6480464 cobaltous chloride results in increased expression of FN1 mRNA CTD PMID:20105288 cobalt dichloride decreases expression ISO RGD:736627 6480464 cobaltous chloride results in decreased expression of FN1 mRNA CTD PMID:19376846 copper atom multiple interactions ISO RGD:736627 6480464 [NSC 689534 binds to Copper] which results in increased expression of FN1 mRNA CTD PMID:20971185 copper atom increases expression EXP   6480464 Copper deficiency results in increased expression of FN1 mRNA CTD PMID:17418555 copper atom multiple interactions ISO RGD:736627 6480464 [FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; more ... CTD PMID:18346929 copper(0) multiple interactions ISO RGD:736627 6480464 [NSC 689534 binds to Copper] which results in increased expression of FN1 mRNA CTD PMID:20971185 copper(0) increases expression EXP   6480464 Copper deficiency results in increased expression of FN1 mRNA CTD PMID:17418555 copper(0) multiple interactions ISO RGD:736627 6480464 [FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; more ... CTD PMID:18346929 crocidolite asbestos decreases expression ISO RGD:736627 6480464 Asbestos, Crocidolite results in decreased expression of FN1 mRNA CTD PMID:18687144 curcumin multiple interactions ISO RGD:736627 6480464 Curcumin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; more ... CTD PMID:12388107 curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein] CTD PMID:21998146 curcumin decreases expression ISO RGD:736627 6480464 Curcumin results in decreased expression of FN1 mRNA CTD PMID:18555241 curcumin multiple interactions ISO RGD:10594 6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FN1 mRNA] CTD PMID:18200517 cyclosporin A decreases expression ISO RGD:736627 6480464 Cyclosporine results in decreased expression of FN1 mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO RGD:10594 6480464 Cyclosporine results in decreased expression of FN1 mRNA CTD PMID:19770486 D-glucose increases expression EXP   6480464 Glucose results in increased expression of FN1 protein CTD PMID:20060012 more ... D-glucose multiple interactions EXP   6480464 N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased expression of FN1 protein]; more ... CTD PMID:21998146 D-glucose increases expression EXP   6480464 Glucose results in increased expression of FN1 protein CTD PMID:20060012 PMID:21998146 D-glucose increases expression ISO RGD:10594 6480464 Glucose results in increased expression of FN1 protein CTD PMID:14520012 PMID:19765649 D-glucose multiple interactions ISO RGD:10594 6480464 resveratrol inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:19765649 D-glucose multiple interactions ISO RGD:736627 6480464 gingerol inhibits the reaction [Glucose results in increased secretion of FN1 protein]; more ... CTD PMID:21829520 D-glucose increases secretion ISO RGD:736627 6480464 Glucose results in increased secretion of FN1 protein CTD PMID:16320596 PMID:21829520 D-glucose increases expression EXP   6480464 Glucose results in increased expression of FN1 protein CTD PMID:20060012 D-glucose multiple interactions EXP   6480464 cinnamic aldehyde inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:20060012 D-glucose increases expression ISO RGD:736627 6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:15086456 more ... D-glucose increases expression ISO RGD:736627 6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:12388107 more ... D-glucose increases expression ISO RGD:736627 6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:17199790 more ... D-glucose increases expression ISO RGD:10594 6480464 Glucose results in increased expression of FN1 mRNA; more ... CTD PMID:14520012 D-glucose multiple interactions ISO RGD:10594 6480464 Enalaprilat inhibits the reaction [Glucose results in increased expression of FN1 mRNA] CTD PMID:14520012 D-glucose increases expression ISO RGD:736627 6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:17199790 more ... D-glucose decreases expression EXP   6480464 Glucose results in decreased expression of FN1 protein CTD PMID:17178593 D-glucose multiple interactions ISO RGD:10594 6480464 TXNIP promotes the reaction [Glucose results in increased expression of FN1 mRNA] CTD PMID:17178593 D-glucose decreases expression ISO RGD:10594 6480464 Glucose results in decreased expression of FN1 protein CTD PMID:17178593 D-glucose multiple interactions ISO RGD:736627 6480464 troglitazone inhibits the reaction [Glucose results in increased expression of FN1 mRNA] CTD PMID:17199790 D-glucose increases expression ISO RGD:736627 6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:12388107 more ... D-glucose increases expression EXP   6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:16572112 D-glucose multiple interactions EXP   6480464 diphenyliodonium inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; more ... CTD PMID:16572112 D-glucose multiple interactions ISO RGD:736627 6480464 Indomethacin inhibits the reaction [Glucose results in increased secretion of FN1 protein] CTD PMID:16320596 D-glucose increases secretion ISO RGD:736627 6480464 Glucose results in increased secretion of FN1 protein CTD PMID:16320596 D-glucose increases expression ISO RGD:736627 6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:12388107 PMID:15086456 D-glucose multiple interactions ISO RGD:736627 6480464 bosentan inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; more ... CTD PMID:12388107 D-glucose multiple interactions ISO RGD:736627 6480464 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; more ... CTD PMID:15086456 D-glucose multiple interactions EXP   6480464 acetovanillone inhibits the reaction [Glucose results in increased expression of FN1 protein]; more ... CTD PMID:22245600 D-penicillamine increases expression EXP   6480464 Penicillamine results in increased expression of FN1 mRNA CTD PMID:19575532 DDT increases expression ISO RGD:736627 6480464 DDT results in increased expression of FN1 protein CTD PMID:22902829 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein] CTD PMID:15030980 dexamethasone decreases expression EXP   6480464 Dexamethasone results in decreased expression of FN1 mRNA CTD PMID:14618091 diarsenic trioxide multiple interactions ISO RGD:10594 6480464 [arsenic trioxide co-treated with FN1 protein] results in decreased expression of POU5F1 mRNA CTD PMID:22641096 diarsenic trioxide increases expression ISO RGD:736627 6480464 arsenic trioxide results in increased expression of FN1 mRNA CTD PMID:17258074 PMID:20458559 diarsenic trioxide increases expression ISO RGD:736627 6480464 arsenic trioxide results in increased expression of FN1 mRNA CTD PMID:20458559 PMID:17258074 diazoxide increases expression ISO RGD:10594 6480464 Isoproterenol results in increased expression of FN1 mRNA CTD PMID:20003209 diazoxide decreases expression ISO RGD:736627 6480464 Isoproterenol results in decreased expression of FN1 protein CTD PMID:11821714 diethylstilbestrol decreases expression EXP   6480464 Diethylstilbestrol results in decreased expression of FN1 mRNA CTD PMID:15890375 dopamine increases expression EXP   6480464 Dopamine results in increased expression of FN1 mRNA CTD PMID:21983523 doxorubicin affects response to substance ISO RGD:736627 6480464 FN1 protein affects the susceptibility to Doxorubicin CTD PMID:16217747 doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of FN1 protein CTD PMID:10430982 PMID:10515446 doxorubicin multiple interactions EXP   6480464 benazepril inhibits the reaction [Doxorubicin results in increased expression of FN1 protein] CTD PMID:10515446 doxorubicin multiple interactions EXP   6480464 Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of FN1 protein] CTD PMID:10430982 doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of FN1 protein CTD PMID:10430982 doxorubicin decreases response to substance ISO RGD:736627 6480464 FN1 protein results in decreased susceptibility to Doxorubicin CTD PMID:17703109 doxorubicin increases expression ISO RGD:10594 6480464 Doxorubicin results in increased expression of FN1 mRNA CTD PMID:15033991 emodin decreases expression EXP   6480464 Emodin results in decreased expression of FN1 mRNA CTD PMID:15288473 enalaprilat dihydrate decreases expression EXP   6480464 Enalaprilat results in decreased expression of FN1 protein; more ... CTD PMID:21795644 enalaprilat dihydrate multiple interactions ISO RGD:10594 6480464 Enalaprilat inhibits the reaction [Glucose results in increased expression of FN1 mRNA] CTD PMID:14520012 endosulfan increases expression ISO RGD:736627 6480464 Endosulfan results in increased expression of FN1 protein CTD PMID:22677888 endosulfan affects expression ISO RGD:736627 6480464 Endosulfan affects the expression of FN1 protein CTD PMID:22902829 esculetin multiple interactions EXP   6480464 esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; more ... CTD PMID:21450970 ethacrynic acid decreases expression ISO RGD:736627 6480464 Ethacrynic Acid results in decreased expression of FN1 mRNA CTD PMID:20011538 ethanol increases expression ISO RGD:736627 6480464 Ethanol results in increased expression of FN1 mRNA CTD PMID:15963989 fenofibrate affects expression EXP   6480464 Fenofibrate affects the expression of FN1 mRNA CTD PMID:20801182 fenoldopam increases expression EXP   6480464 Fenoldopam results in increased expression of FN1 mRNA CTD PMID:21983523 furan increases methylation EXP   6480464 furan results in increased methylation of FN1 gene CTD PMID:22079235 gamma-hexachlorocyclohexane affects expression EXP   6480464 Lindane affects the expression of FN1 mRNA CTD PMID:17785943 glucose increases expression EXP   6480464 Glucose results in increased expression of FN1 protein CTD PMID:20060012 more ... glucose multiple interactions EXP   6480464 N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased expression of FN1 protein]; more ... CTD PMID:21998146 glucose increases expression EXP   6480464 Glucose results in increased expression of FN1 protein CTD PMID:20060012 PMID:21998146 glucose multiple interactions ISO RGD:10594 6480464 resveratrol inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:19765649 glucose increases expression ISO RGD:10594 6480464 Glucose results in increased expression of FN1 protein CTD PMID:14520012 PMID:19765649 glucose multiple interactions ISO RGD:736627 6480464 gingerol inhibits the reaction [Glucose results in increased secretion of FN1 protein]; more ... CTD PMID:21829520 glucose increases secretion ISO RGD:736627 6480464 Glucose results in increased secretion of FN1 protein CTD PMID:16320596 PMID:21829520 glucose increases expression EXP   6480464 Glucose results in increased expression of FN1 protein CTD PMID:20060012 glucose multiple interactions EXP   6480464 cinnamic aldehyde inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:20060012 glucose increases expression ISO RGD:736627 6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:15086456 more ... glucose increases expression ISO RGD:736627 6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:12388107 more ... glucose increases expression ISO RGD:736627 6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:17199790 more ... glucose increases expression ISO RGD:10594 6480464 Glucose results in increased expression of FN1 mRNA; more ... CTD PMID:14520012 glucose multiple interactions ISO RGD:10594 6480464 Enalaprilat inhibits the reaction [Glucose results in increased expression of FN1 mRNA] CTD PMID:14520012 glucose increases expression ISO RGD:736627 6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:17199790 more ... glucose decreases expression EXP   6480464 Glucose results in decreased expression of FN1 protein CTD PMID:17178593 glucose multiple interactions ISO RGD:10594 6480464 TXNIP promotes the reaction [Glucose results in increased expression of FN1 mRNA] CTD PMID:17178593 glucose decreases expression ISO RGD:10594 6480464 Glucose results in decreased expression of FN1 protein CTD PMID:17178593 glucose multiple interactions ISO RGD:736627 6480464 troglitazone inhibits the reaction [Glucose results in increased expression of FN1 mRNA] CTD PMID:17199790 glucose increases expression ISO RGD:736627 6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:12388107 more ... glucose increases expression EXP   6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:16572112 glucose multiple interactions EXP   6480464 diphenyliodonium inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; more ... CTD PMID:16572112 glucose multiple interactions ISO RGD:736627 6480464 Indomethacin inhibits the reaction [Glucose results in increased secretion of FN1 protein] CTD PMID:16320596 glucose increases secretion ISO RGD:736627 6480464 Glucose results in increased secretion of FN1 protein CTD PMID:16320596 glucose increases expression ISO RGD:736627 6480464 Glucose results in increased expression of FN1 mRNA CTD PMID:12388107 PMID:15086456 glucose multiple interactions ISO RGD:736627 6480464 bosentan inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; more ... CTD PMID:12388107 glucose multiple interactions ISO RGD:736627 6480464 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; more ... CTD PMID:15086456 glucose multiple interactions EXP   6480464 acetovanillone inhibits the reaction [Glucose results in increased expression of FN1 protein]; more ... CTD PMID:22245600 glutathione multiple interactions EXP   6480464 [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; more ... CTD PMID:19524604 heptachlor increases expression ISO RGD:736627 6480464 Heptachlor results in increased expression of FN1 protein CTD PMID:22902829 hexachlorobenzene increases expression EXP   6480464 Hexachlorobenzene results in increased expression of FN1 mRNA CTD PMID:15159207 hydrogen peroxide multiple interactions ISO RGD:736627 6480464 calphostin C inhibits the reaction [Hydrogen Peroxide results in increased secretion of FN1 protein] CTD PMID:15086456 hydrogen peroxide multiple interactions EXP   6480464 tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of FN1 mRNA] CTD PMID:23022513 hydrogen peroxide increases expression EXP   6480464 Hydrogen Peroxide results in increased expression of FN1 mRNA CTD PMID:23022513 hydrogen peroxide multiple interactions EXP   6480464 Hydrogen Peroxide results in decreased expression of and results in decreased secretion of FN1 protein CTD PMID:19524604 hydrogen peroxide increases secretion ISO RGD:736627 6480464 Hydrogen Peroxide results in increased secretion of FN1 protein CTD PMID:15086456 hydrogen peroxide increases expression ISO RGD:736627 6480464 Hydrogen Peroxide results in increased expression of FN1 protein CTD PMID:15147944 hydroquinone affects expression ISO RGD:736627 6480464 hydroquinone affects the expression of FN1 mRNA CTD PMID:15452088 indomethacin multiple interactions ISO RGD:736627 6480464 Indomethacin inhibits the reaction [Lipopolysaccharides results in increased secretion of FN1 protein]; more ... CTD PMID:16320596 isoprenaline decreases expression ISO RGD:736627 6480464 Isoproterenol results in decreased expression of FN1 protein CTD PMID:11821714 isoprenaline increases expression ISO RGD:10594 6480464 Isoproterenol results in increased expression of FN1 mRNA CTD PMID:20003209 isotretinoin increases expression ISO RGD:736627 6480464 Isotretinoin results in increased expression of FN1 mRNA CTD PMID:20436886 L-ascorbic acid multiple interactions ISO RGD:736627 6480464 [Tretinoin co-treated with Ascorbic Acid] results in increased expression of FN1 mRNA CTD PMID:16443354 lead diacetate increases expression EXP   6480464 lead acetate results in increased expression of FN1 mRNA CTD PMID:22641619 lead(0) increases expression ISO RGD:736627 6480464 Lead results in increased expression of FN1 mRNA CTD PMID:19921347 linalool increases expression ISO RGD:736627 6480464 linalool results in increased expression of FN1 mRNA CTD PMID:19922762 losartan decreases expression EXP   6480464 Losartan results in decreased expression of FN1 mRNA; more ... CTD PMID:16191423 manganese(II) chloride multiple interactions EXP   6480464 [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; more ... CTD PMID:19524604 manganese(II) chloride increases expression EXP   6480464 manganese chloride results in increased expression of FN1 mRNA CTD PMID:19524604 mangiferin multiple interactions EXP   6480464 mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; more ... CTD PMID:19706694 medroxyprogesterone acetate multiple interactions ISO RGD:736627 6480464 [Medroxyprogesterone Acetate co-treated with Carbon Tetrachloride] results in increased expression of FN1 protein CTD PMID:1465320 melamine multiple interactions ISO RGD:736627 6480464 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of FN1 mRNA]; more ... CTD PMID:22915474 melamine increases expression ISO RGD:736627 6480464 melamine results in increased expression of FN1 protein; more ... CTD PMID:22915474 melatonin multiple interactions EXP   6480464 Melatonin inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; more ... CTD PMID:19524604 mercury atom decreases expression ISO RGD:736627 6480464 Mercury results in decreased expression of FN1 mRNA CTD PMID:16823088 mercury dichloride affects folding EXP   6480464 Mercuric Chloride affects the folding of FN1 protein CTD PMID:11768240 mercury dichloride increases expression EXP   6480464 Mercuric Chloride results in increased expression of FN1 protein CTD PMID:11768240 mercury dichloride affects binding EXP   6480464 Mercuric Chloride binds to FN1 protein CTD PMID:11768240 mercury(0) decreases expression ISO RGD:736627 6480464 Mercury results in decreased expression of FN1 mRNA CTD PMID:16823088 methamphetamine increases expression ISO RGD:10594 6480464 Methamphetamine results in increased expression of FN1 mRNA CTD PMID:12766323 methapyrilene decreases expression EXP   6480464 Methapyrilene results in decreased expression of FN1 mRNA CTD PMID:15890375 methotrexate increases expression ISO RGD:736627 6480464 Methotrexate results in increased expression of FN1 mRNA CTD PMID:17400583 methylglyoxal multiple interactions EXP   6480464 diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA]; more ... CTD PMID:17635749 methylglyoxal increases expression EXP   6480464 Pyruvaldehyde results in increased expression of FN1 mRNA CTD PMID:17635749 methylmercury chloride affects expression EXP   6480464 methylmercuric chloride affects the expression of FN1 mRNA CTD PMID:20864626 microcystin-LR decreases expression ISO RGD:10594 6480464 cyanoginosin LR results in decreased expression of FN1 mRNA CTD PMID:17383702 morphine increases expression ISO RGD:10594 6480464 Morphine results in increased expression of FN1 mRNA CTD PMID:20144693 N-acetyl-L-cysteine multiple interactions EXP   6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:22245600 N-acetyl-L-cysteine multiple interactions ISO RGD:736627 6480464 Acetylcysteine inhibits the reaction [advanced glycation end products-bovine serum albumin results in increased expression of FN1 protein]; more ... CTD PMID:19553346 N-methylformamide decreases expression ISO RGD:10594 6480464 methylformamide analog results in decreased expression of FN1 mRNA; more ... CTD PMID:17040096 N-nitrosodiethylamine multiple interactions EXP   6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of FN1 mRNA CTD PMID:17602206 N-nitrosodimethylamine decreases expression EXP   6480464 Dimethylnitrosamine results in decreased expression of FN1 mRNA CTD PMID:15890375 nitroprusside multiple interactions ISO RGD:736627 6480464 Nitroprusside inhibits the reaction [advanced glycation end products-bovine serum albumin results in increased expression of FN1 protein]; more ... CTD PMID:19553346 ozone multiple interactions EXP   6480464 IL10 protein inhibits the reaction [Ozone results in increased expression of FN1 mRNA]; more ... CTD PMID:10593593 ozone multiple interactions EXP   6480464 IFNG protein inhibits the reaction [Ozone results in increased expression of FN1 protein]; more ... CTD PMID:8086166 ozone increases expression EXP   6480464 Ozone results in increased expression of FN1 protein CTD PMID:10405187 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of FN1 mRNA CTD PMID:10405187 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of FN1 protein CTD PMID:9700094 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of FN1 mRNA CTD PMID:8295431 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of FN1 protein CTD PMID:10593593 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of FN1 protein CTD PMID:12377989 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of FN1 mRNA CTD PMID:10405187 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of FN1 protein CTD PMID:10405187 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of FN1 mRNA CTD PMID:8295431 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of FN1 protein CTD PMID:9700094 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of FN1 mRNA CTD PMID:8295431 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of FN1 protein CTD PMID:12377989 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of FN1 mRNA CTD PMID:9700094 more ... ozone affects expression EXP   6480464 Ozone affects the expression of FN1 mRNA CTD PMID:10562695 paracetamol affects expression ISO RGD:10594 6480464 Acetaminophen affects the expression of FN1 mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:736627 6480464 Acetaminophen results in decreased expression of FN1 mRNA CTD PMID:21420995 paraquat decreases expression ISO RGD:10594 6480464 Paraquat results in decreased expression of FN1 mRNA CTD PMID:16797015 paraquat increases expression ISO RGD:10594 6480464 Paraquat results in increased expression of FN1 mRNA CTD PMID:17215068 perfluorooctanoic acid decreases expression EXP   6480464 perfluorooctanoic acid results in decreased expression of FN1 mRNA CTD PMID:19162173 phenobarbital decreases expression EXP   6480464 Phenobarbital results in decreased expression of FN1 mRNA CTD PMID:19162173 phenobarbital decreases expression ISO RGD:10594 6480464 Phenobarbital results in decreased expression of FN1 mRNA CTD PMID:23091169 phenobarbital affects expression ISO RGD:736627 6480464 Phenobarbital affects the expression of FN1 mRNA CTD PMID:19159669 phenylephrine increases expression ISO RGD:736627 6480464 Phenylephrine results in increased expression of FN1 protein CTD PMID:11821714 phenytoin increases expression ISO RGD:736627 6480464 Phenytoin results in increased expression of FN1 mRNA CTD PMID:14741686 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736627 6480464 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of FN1 protein]; more ... CTD PMID:15086456 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736627 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of FN1 mRNA CTD PMID:16979875 phorbol 13-acetate 12-myristate increases secretion ISO RGD:736627 6480464 Tetradecanoylphorbol Acetate results in increased secretion of FN1 protein CTD PMID:15086456 piperonyl butoxide decreases expression EXP   6480464 Piperonyl Butoxide results in decreased expression of FN1 mRNA CTD PMID:15890375 pirinixic acid decreases expression ISO RGD:10594 6480464 pirinixic acid results in decreased expression of FN1 mRNA CTD PMID:17426115 pirinixic acid decreases expression EXP   6480464 pirinixic acid results in decreased expression of FN1 mRNA CTD PMID:15890375 pirinixic acid increases expression ISO RGD:10594 6480464 pirinixic acid results in increased expression of FN1 mRNA CTD PMID:18445702 prazosin multiple interactions ISO RGD:736627 6480464 [Norepinephrine co-treated with Prazosin] results in decreased expression of FN1 protein CTD PMID:11821714 pregnenolone 16alpha-carbonitrile decreases expression EXP   6480464 Pregnenolone Carbonitrile results in decreased expression of FN1 mRNA CTD PMID:19162173 progesterone decreases expression ISO RGD:736627 6480464 Progesterone results in decreased expression of FN1 mRNA CTD PMID:18070364 propiconazole decreases expression ISO RGD:10594 6480464 propiconazole results in decreased expression of FN1 mRNA CTD PMID:21278054 propranolol multiple interactions ISO RGD:736627 6480464 [Norepinephrine co-treated with Propranolol] results in increased expression of FN1 protein CTD PMID:11821714 pyridoxal 5'-phosphate multiple interactions EXP   6480464 Pyridoxal Phosphate inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] CTD PMID:8151099 quercetin decreases expression ISO RGD:736627 6480464 Quercetin results in decreased expression of FN1 mRNA CTD PMID:15309432 quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of FN1 protein CTD PMID:15573758 raloxifene multiple interactions ISO RGD:10594 6480464 Raloxifene inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA] CTD PMID:15920148 resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [[[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of FN1 protein]; more ... CTD PMID:22245600 resveratrol multiple interactions ISO RGD:736627 6480464 resveratrol inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; more ... CTD PMID:23146760 resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of FN1 mRNA CTD PMID:19228061 resveratrol decreases expression ISO RGD:736627 6480464 resveratrol results in decreased expression of FN1 mRNA CTD PMID:20878097 resveratrol multiple interactions ISO RGD:10594 6480464 resveratrol inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:19765649 resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:21300041 rosiglitazone decreases expression ISO RGD:736627 6480464 rosiglitazone results in decreased expression of FN1 protein; more ... CTD PMID:15908479 rosiglitazone multiple interactions EXP   6480464 rosiglitazone inhibits the reaction [AGT protein results in increased expression of FN1 mRNA] CTD PMID:18278065 rosiglitazone increases expression ISO RGD:736627 6480464 rosiglitazone results in increased expression of FN1 mRNA CTD PMID:16982809 PMID:17148569 rosiglitazone increases expression EXP   6480464 rosiglitazone results in increased expression of FN1 mRNA CTD PMID:19397913 PMID:21172411 rosiglitazone increases expression ISO RGD:736627 6480464 rosiglitazone results in increased expression of FN1 mRNA CTD PMID:17148569 PMID:16982809 rosiglitazone increases expression EXP   6480464 rosiglitazone results in increased expression of FN1 mRNA CTD PMID:21172411 PMID:19397913 rosiglitazone multiple interactions ISO RGD:736627 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone results in decreased expression of FN1 protein]; more ... CTD PMID:15908479 rosiglitazone increases expression EXP   6480464 rosiglitazone results in increased expression of FN1 mRNA CTD PMID:19397913 rosiglitazone increases expression ISO RGD:736627 6480464 rosiglitazone results in increased expression of FN1 mRNA CTD PMID:16982809 rotenone multiple interactions ISO RGD:736627 6480464 Rotenone inhibits the reaction [Glucose results in increased secretion of FN1 protein] CTD PMID:15086456 rotenone decreases secretion ISO RGD:736627 6480464 Rotenone results in decreased secretion of FN1 protein CTD PMID:17651460 rotenone decreases expression ISO RGD:736627 6480464 Rotenone results in decreased expression of FN1 mRNA CTD PMID:17651460 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP   6480464 [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein] CTD PMID:19524604 silver atom affects expression ISO RGD:736627 6480464 Silver affects the expression of FN1 mRNA CTD PMID:22342292 silver(0) affects expression ISO RGD:736627 6480464 Silver affects the expression of FN1 mRNA CTD PMID:22342292 simvastatin decreases expression ISO RGD:10594 6480464 Simvastatin results in decreased expression of FN1 mRNA CTD PMID:10412775 simvastatin decreases expression EXP   6480464 Simvastatin results in decreased expression of FN1 mRNA CTD PMID:16414398 PMID:15855201 simvastatin decreases expression EXP   6480464 Simvastatin results in decreased expression of FN1 mRNA CTD PMID:15855201 PMID:16414398 simvastatin increases expression ISO RGD:10594 6480464 Simvastatin results in increased expression of FN1 mRNA CTD PMID:16274305 sodium hydrogencarbonate multiple interactions EXP   6480464 Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of FN1 protein] CTD PMID:10430982 sphingosine 1-phosphate multiple interactions EXP   6480464 Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein] CTD PMID:21998146 sphingosine 1-phosphate increases expression EXP   6480464 sphingosine 1-phosphate results in increased expression of FN1 protein CTD PMID:21998146 staurosporine multiple interactions EXP   6480464 Staurosporine inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] CTD PMID:7945571 streptozocin multiple interactions EXP   6480464 Aspirin inhibits the reaction [Streptozocin results in increased expression of FN1] CTD PMID:14586741 streptozocin increases expression EXP   6480464 Streptozocin results in increased expression of FN1 protein CTD PMID:12140129 more ... streptozocin increases expression EXP   6480464 Streptozocin results in increased expression of FN1 protein CTD PMID:12140129 more ... streptozocin increases expression EXP   6480464 Streptozocin results in increased expression of FN1 mRNA CTD PMID:11798618 more ... streptozocin multiple interactions EXP   6480464 esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; more ... CTD PMID:21450970 streptozocin increases expression EXP   6480464 Streptozocin results in increased expression of FN1 mRNA CTD PMID:11798618 PMID:16973718 streptozocin multiple interactions EXP   6480464 benazepril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA] CTD PMID:11798618 streptozocin increases expression EXP   6480464 Streptozocin results in increased expression of FN1 protein CTD PMID:12140129 more ... streptozocin increases expression EXP   6480464 Streptozocin results in increased expression of FN1 protein CTD PMID:21300041 more ... streptozocin multiple interactions EXP   6480464 carvedilol inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:12140129 streptozocin increases expression EXP   6480464 Streptozocin results in increased expression of FN1 protein CTD PMID:19895808 PMID:21300041 streptozocin multiple interactions EXP   6480464 XLF-III-43 inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:19895808 streptozocin increases expression EXP   6480464 Streptozocin results in increased expression of FN1 protein CTD PMID:21300041 PMID:19895808 streptozocin multiple interactions EXP   6480464 resveratrol inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:21300041 streptozocin increases expression EXP   6480464 Streptozocin results in increased expression of FN1 mRNA CTD PMID:16973718 streptozocin multiple interactions EXP   6480464 Trientine inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA] CTD PMID:16973718 streptozocin increases expression EXP   6480464 Streptozocin results in increased expression of FN1 CTD PMID:14586741 superoxide multiple interactions EXP   6480464 Superoxides affects the reaction [Glucose results in increased expression of FN1 mRNA]; more ... CTD PMID:16572112 tacrolimus hydrate multiple interactions ISO RGD:10594 6480464 Tacrolimus inhibits the reaction [NPR1 protein affects the expression of FN1 mRNA] CTD PMID:15939815 tamoxifen affects expression ISO RGD:736627 6480464 Tamoxifen affects the expression of FN1 mRNA CTD PMID:14699072 tamoxifen affects expression ISO RGD:10594 6480464 Tamoxifen affects the expression of FN1 mRNA CTD PMID:20937368 taurine multiple interactions ISO RGD:736627 6480464 Taurine inhibits the reaction [advanced glycation end products-bovine serum albumin results in increased expression of FN1 protein]; more ... CTD PMID:19553346 telmisartan multiple interactions EXP   6480464 telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; more ... CTD PMID:19706694 tert-butyl hydroperoxide increases expression ISO RGD:736627 6480464 tert-Butylhydroperoxide results in increased expression of FN1 mRNA CTD PMID:15963989 tetrachloromethane multiple interactions ISO RGD:736627 6480464 [Medroxyprogesterone Acetate co-treated with Carbon Tetrachloride] results in increased expression of FN1 protein CTD PMID:1465320 tetrachloromethane increases expression ISO RGD:10594 6480464 Carbon Tetrachloride results in increased expression of FN1 mRNA CTD PMID:16539848 PMID:16508911 tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of FN1 protein CTD PMID:15030980 PMID:17631135 tetrachloromethane affects expression EXP   6480464 Carbon Tetrachloride affects the expression of FN1 mRNA CTD PMID:16239168 tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of FN1 protein CTD PMID:17631135 PMID:15030980 tetrachloromethane multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]; more ... CTD PMID:15030980 tetrachloromethane multiple interactions ISO RGD:10594 6480464 PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA] CTD PMID:18038451 tetrachloromethane multiple interactions ISO RGD:10594 6480464 IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA] CTD PMID:16539848 tetrachloromethane increases expression ISO RGD:10594 6480464 Carbon Tetrachloride results in increased expression of FN1 CTD PMID:20821823 tetrachloromethane multiple interactions ISO RGD:10594 6480464 Bee Venoms inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1] CTD PMID:20821823 tetrachloromethane increases expression ISO RGD:10594 6480464 Carbon Tetrachloride results in increased expression of FN1 mRNA CTD PMID:16508911 PMID:16539848 tetrachloromethane affects expression ISO RGD:10594 6480464 Carbon Tetrachloride affects the expression of FN1 mRNA CTD PMID:17484886 thioacetamide increases expression ISO RGD:10594 6480464 Thioacetamide results in increased expression of FN1 mRNA CTD PMID:16511523 titanium dioxide increases expression ISO RGD:736627 6480464 titanium dioxide results in increased expression of FN1 mRNA CTD PMID:19695317 titanium dioxide increases expression ISO RGD:736627 6480464 titanium dioxide results in increased expression of FN1 mRNA CTD PMID:19695317 PMID:22342292 toluene multiple interactions ISO RGD:10594 6480464 Toluene promotes the reaction [SERPINB14 protein results in increased expression of FN1 protein] CTD PMID:21601613 toluene increases expression ISO RGD:10594 6480464 Toluene results in increased expression of FN1 protein CTD PMID:21601613 trans-resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [[[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of FN1 protein]; more ... CTD PMID:22245600 trans-resveratrol multiple interactions ISO RGD:736627 6480464 resveratrol inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; more ... CTD PMID:23146760 trans-resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of FN1 mRNA CTD PMID:19228061 trans-resveratrol decreases expression ISO RGD:736627 6480464 resveratrol results in decreased expression of FN1 mRNA CTD PMID:20878097 trans-resveratrol multiple interactions ISO RGD:10594 6480464 resveratrol inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:19765649 trans-resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:21300041 tributylstannane multiple interactions ISO RGD:10594 6480464 tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA] CTD PMID:22749964 troglitazone multiple interactions ISO RGD:736627 6480464 PPARG protein promotes the reaction [troglitazone results in decreased expression of FN1 protein]; more ... CTD PMID:15908479 troglitazone decreases secretion ISO RGD:736627 6480464 troglitazone results in decreased secretion of FN1 protein CTD PMID:17199790 troglitazone multiple interactions ISO RGD:736627 6480464 troglitazone inhibits the reaction [TGFB2 protein results in increased expression of FN1 mRNA]; more ... CTD PMID:18253093 troglitazone multiple interactions ISO RGD:736627 6480464 troglitazone inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; more ... CTD PMID:17056281 troglitazone multiple interactions ISO RGD:736627 6480464 troglitazone inhibits the reaction [Glucose results in increased expression of FN1 mRNA] CTD PMID:17199790 troglitazone decreases expression ISO RGD:736627 6480464 troglitazone results in decreased expression of FN1 mRNA; more ... CTD PMID:15908479 vancomycin increases expression EXP   6480464 Vancomycin results in increased expression of FN1 mRNA CTD PMID:18289764 vancomycin decreases expression ISO RGD:10594 6480464 Vancomycin results in decreased expression of FN1 mRNA CTD PMID:18930951 vincaleukoblastine affects response to substance ISO RGD:736627 6480464 FN1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 zinc atom multiple interactions ISO RGD:736627 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of FN1 mRNA CTD PMID:16979875 zinc(0) multiple interactions ISO RGD:736627 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of FN1 mRNA CTD PMID:16979875 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) acute-phase response   IEA UniProtKB-KW:KW-0011 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 angiogenesis   IEA UniProtKB-KW:KW-0037 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 calcium-independent cell-matrix adhesion   ISO RGD:10594 1624291 MGI:MGI:4397493|PMID:19651211 RGD MGI:MGI:4397493 PMID:19651211 cell activation   IMP   7205469   RGD   cell adhesion   ISO RGD:10594 1624291 MGI:MGI:2180235|PMID:12021259 RGD MGI:MGI:2180235 PMID:12021259 cell adhesion   ISO RGD:10594 1624291 MGI:MGI:1195020|PMID:9441684 RGD MGI:MGI:1195020 PMID:9441684 cell-matrix adhesion   IMP   1358623   RGD   cell-matrix adhesion   ISO RGD:10594 1624291 MGI:MGI:3577694|PMID:15728191 RGD MGI:MGI:3577694 PMID:15728191 cell-substrate junction assembly   ISO RGD:10594 1624291 MGI:MGI:2667760|PMID:12867986 RGD MGI:MGI:2667760 PMID:12867986 cellular response to BMP stimulus   IEP   7205471   RGD   cellular response to glucose stimulus   IEP   7205438   RGD   cellular response to interleukin-1   IMP   7205467   RGD   cellular response to lipopolysaccharide   IEP   7205475   RGD   cellular response to mercury ion   IDA   729934   RGD   cellular response to platelet-derived growth factor stimulus   IEP   7205462   RGD   cellular response to prostaglandin E stimulus   IEP   1601193   RGD   cellular response to transforming growth factor beta stimulus   IEP   1626090   RGD   cellular response to vascular endothelial growth factor stimulus   IEP   7205435   RGD   extracellular matrix organization   IMP   1358623   RGD   glial cell migration   IDA   2325332   RGD   negative regulation of apoptotic process   IMP   1601192   RGD   ossification   TAS   1601193   RGD   peptide cross-linking   ISO RGD:736627 1624291 PMID:3997886 RGD PMID:3997886 positive regulation of cell migration   IMP   7205631   RGD   positive regulation of chemotaxis   IDA   7205628   RGD   positive regulation of peptidase activity   ISO RGD:10594 1624291 MGI:MGI:3607633|PMID:16061471 RGD MGI:MGI:3607633 PMID:16061471 regulation of cell shape   IEA UniProtKB-KW:KW-0133 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 response to glucocorticoid stimulus   IEP   7205463   RGD   response to ischemia   IEP   7205472   RGD   response to ozone   IEP   7205636   RGD   response to wounding   IEP   7205465   RGD   substrate adhesion-dependent cell spreading   ISO RGD:736627 1624291 PMID:16236823 RGD PMID:16236823 wound healing   ISO RGD:10594 1624291 MGI:MGI:2655542 RGD MGI:MGI:2667261 PMID:12847088 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) apical plasma membrane   ISO RGD:10594 1624291 MGI:MGI:1355040|PMID:10742111 RGD MGI:MGI:1355040 PMID:10742111 basement membrane   ISO RGD:10594 1624291 MGI:MGI:77581|PMID:8984825 RGD MGI:MGI:77581 PMID:8984825 basement membrane   IDA   1578551   RGD   basement membrane   ISO RGD:10594 1624291 MGI:MGI:2149189|PMID:11511678 RGD MGI:MGI:2149189 PMID:11511678 endoplasmic reticulum-Golgi intermediate compartment   ISO RGD:736627 1624291 PMID:15308636 RGD PMID:15308636 extracellular matrix   ISO RGD:10594 1624291 MGI:MGI:2149189|PMID:11511678 RGD MGI:MGI:2149189 PMID:11511678 extracellular matrix colocalizes_with ISO RGD:736627 1624291 PMID:20551380 RGD PMID:20551380 extracellular matrix   ISO RGD:736627 1624291 PMID:1632457 RGD PMID:1632457 extracellular matrix   ISO RGD:10594 1624291 MGI:MGI:3806197|PMID:18559979 RGD MGI:MGI:3806197 PMID:18559979 extracellular matrix   ISO RGD:10594 1624291 MGI:MGI:80427|PMID:2209468 RGD MGI:MGI:80427 PMID:2209468 extracellular matrix   ISO RGD:10594 1624291 MGI:MGI:3628676|PMID:15065125 RGD MGI:MGI:3628676 PMID:15065125 extracellular region   IEA InterPro:IPR000083 1600115 GO_REF:0000002 InterPro GO_REF:0000002 extracellular space   IDA   7205629   RGD   extracellular space   ISO RGD:736627 1624291 PMID:20551380 RGD PMID:20551380 fibrinogen complex   ISO RGD:736627 1624291 PMID:3997886 RGD PMID:3997886 proteinaceous extracellular matrix   TAS   729934   RGD   proteinaceous extracellular matrix   ISO RGD:10594 1624291 MGI:MGI:1101335|PMID:9421166 RGD MGI:MGI:1101335 PMID:9421166 proteinaceous extracellular matrix   ISO RGD:10594 1624291 MGI:MGI:3577694|PMID:15728191 RGD MGI:MGI:3577694 PMID:15728191 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) extracellular matrix structural constituent   TAS   1601194   RGD   heparin binding   IEA UniProtKB-KW:KW-0358 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 mercury ion binding   IDA   729934   RGD   peptidase activator activity   ISO RGD:10594 1624291 MGI:MGI:3607633|PMID:16061471 RGD MGI:MGI:3607633 PMID:16061471 protease binding   IPI RGD:620196 2296060   RGD   protease binding   IPI RGD:621320 2296060   RGD   protease binding   IPI RGD:621316 2296060   RGD   protein binding   ISO RGD:10594 1624291 UniProtKB:P55002 RGD MGI:MGI:3785344 PMID:18281502 protein binding   ISO RGD:736627 1624291 UniProtKB:P21980 RGD PMID:22442151 protein binding   ISO RGD:736627 1624291 UniProtKB:P21980 RGD PMID:19738201 protein binding   ISO RGD:10594 1624291 UniProtKB:Q8CIH5 RGD MGI:MGI:3688344 PMID:15102471 protein binding   IPI UniProtKB:P34901   PMID:10640397 IntAct PMID:10640397 protein binding   ISO RGD:736627 1624291 UniProtKB:P08519 RGD PMID:2531657 protein binding   ISO RGD:736627 1624291 UniProtKB:O95633 RGD PMID:16336961 protein binding   ISO RGD:736627 1624291 UniProtKB:Q07092 RGD PMID:15165854 protein binding   ISO RGD:736627 1624291 UniProtKB:P49747 RGD PMID:12225811 protein binding   ISO RGD:736627 1624291 UniProtKB:Q5TAT6 RGD PMID:11956183 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell-extracellular matrix signaling pathway   IEA RGD:2624 6907045   KEGG rno:04512 Entamoeba histolyca infection pathway   IEA RGD:2624 6907045   KEGG rno:05146 small cell lung cancer pathway   IEA RGD:2624 6907045   KEGG rno:05222 syndecan signaling pathway   ISO RGD:736627 6484113   PID PID:200134 syndecan signaling pathway   ISO RGD:736627 6484113   PID PID:200192 External Database Links KEGG Pathway Amoebiasis Bacterial invasion of epithelial cells ECM-receptor interaction Focal adhesion Pathways in cancer PI3K-Akt signaling pathway Regulation of actin cytoskeleton Small cell lung cancer Pathway Interaction Database Alpha4 beta1 integrin signaling events (PID:200221) Alpha9 beta1 integrin signaling events (PID:200093) Angiopoietin receptor Tie2-mediated signaling (PID:200079) Beta1 integrin cell surface interactions (PID:200016) Beta3 integrin cell surface interactions (PID:200043) Beta5 beta6 beta7 and beta8 integrin cell surface interactions (PID:200169) Integrins in angiogenesis (PID:200128) Syndecan-2-mediated signaling events (PID:200192) Syndecan-4-mediated signaling events (PID:200134) Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling (PID:200139) VEGFR3 signaling in lymphatic endothelium (PID:200218) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal apoptosis   IEA   704404   RGD   Disease Annotations Acute Kidney Injury  (IEP) Carcinoma, Renal Cell  (ISS) Diabetes Mellitus  (ISS) Diabetes Mellitus, Experimental  (IEP) Diabetic Angiopathies  (IED) Diabetic Nephropathies  (ISS) Glomerulonephritis  (ISS) Glomerulonephritis, IGA  (ISS) Glomerulonephritis, Membranoproliferative  (IEP) Glomerulopathy with fibronectin deposits  (ISS) Hypertension, Renovascular  (IED) Kidney Failure, Chronic  (ISS) Kidney Reperfusion Injury  (IEP) Liver Injury  (IEP) Liver Reperfusion Injury  (IED) Myocardial Infarction  (IEP) Nephrolithiasis  (IEP,ISS) Pneumonia, Staphylococcal  (IED) Spinal Cord Injuries  (ISS) Sturge-Weber Syndrome  (ISS) Submandibular Gland Diseases  (IEP) Ureteral Obstruction  (IEP) Urinary Bladder Neoplasms  (ISS) VATER association  (IEP) Gene-Chemical Interaction Annotations (R)-noradrenaline  (ISO) (S)-nicotine  (ISO) 17alpha-ethynylestradiol  (EXP,ISO) 17beta-estradiol  (ISO) 2,2',4,4',5,5'-hexachlorobiphenyl  (EXP) 2,2,2-tetramine  (EXP) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2,3-dimethoxynaphthalene-1,4-dione  (EXP) 2,4,6-trinitrobenzenesulfonic acid  (ISO) 2,4-dinitrotoluene  (EXP) 2-acetamidofluorene  (EXP) 2-amino-2-deoxy-D-glucopyranose  (EXP,ISO) 2-naphthylamine  (ISO) 2-nitrofluorene  (EXP) 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP) 3,3',4,4',5-pentachlorobiphenyl  (ISO) 4,4'-diaminodiphenylmethane  (EXP) 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP) 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO) 5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP) 5-fluorouracil  (ISO) 7,12-dimethyltetraphene  (EXP) 8-bromo-3',5'-cyclic AMP  (ISO) 9-cis-retinoic acid  (EXP,ISO) acetaldehyde  (EXP,ISO) acetylsalicylic acid  (EXP) actinomycin D  (ISO) afimoxifene  (ISO) aflatoxin B1  (EXP) aldehydo-D-glucosamine  (EXP,ISO) all-trans-retinoic acid  (EXP,ISO) all-trans-retinol  (ISO) alpha-hexachlorocyclohexane  (EXP) aluminium oxide  (ISO) ammonium chloride  (EXP) apocynin  (EXP,ISO) arsenite(3-)  (ISO) asbestos  (ISO) bacitracin  (EXP) benazepril  (EXP) benzo[a]pyrene  (ISO) beta-D-glucosamine  (EXP,ISO) bezafibrate  (EXP) bis(2-chloroethyl) sulfide  (ISO) bisphenol A  (ISO) bosentan  (ISO) bromobenzene  (EXP) bromochloroacetic acid  (ISO) cadmium dichloride  (ISO) cadmium selenide  (ISO) carbonyl sulfide  (EXP) carvedilol  (EXP) chloroprene  (ISO) cisplatin  (EXP,ISO) clofibrate  (EXP) clofibric acid  (EXP) cobalt atom  (ISO) cobalt dichloride  (ISO) copper atom  (EXP,ISO) copper(0)  (EXP,ISO) crocidolite asbestos  (ISO) curcumin  (EXP,ISO) cyclosporin A  (ISO) D-glucose  (EXP,ISO) D-penicillamine  (EXP) DDT  (ISO) dexamethasone  (EXP) diarsenic trioxide  (ISO) diazoxide  (ISO) diethylstilbestrol  (EXP) dopamine  (EXP) doxorubicin  (EXP,ISO) emodin  (EXP) enalaprilat dihydrate  (EXP,ISO) endosulfan  (ISO) esculetin  (EXP) ethacrynic acid  (ISO) ethanol  (ISO) fenofibrate  (EXP) fenoldopam  (EXP) furan  (EXP) gamma-hexachlorocyclohexane  (EXP) glucose  (EXP,ISO) glutathione  (EXP) heptachlor  (ISO) hexachlorobenzene  (EXP) hydrogen peroxide  (EXP,ISO) hydroquinone  (ISO) indomethacin  (ISO) isoprenaline  (ISO) isotretinoin  (ISO) L-ascorbic acid  (ISO) lead diacetate  (EXP) lead(0)  (ISO) linalool  (ISO) losartan  (EXP) manganese(II) chloride  (EXP) mangiferin  (EXP) medroxyprogesterone acetate  (ISO) melamine  (ISO) melatonin  (EXP) mercury atom  (ISO) mercury dichloride  (EXP) mercury(0)  (ISO) methamphetamine  (ISO) methapyrilene  (EXP) methotrexate  (ISO) methylglyoxal  (EXP) methylmercury chloride  (EXP) microcystin-LR  (ISO) morphine  (ISO) N-acetyl-L-cysteine  (EXP,ISO) N-methylformamide  (ISO) N-nitrosodiethylamine  (EXP) N-nitrosodimethylamine  (EXP) nitroprusside  (ISO) ozone  (EXP) paracetamol  (ISO) paraquat  (ISO) perfluorooctanoic acid  (EXP) phenobarbital  (EXP,ISO) phenylephrine  (ISO) phenytoin  (ISO) phorbol 13-acetate 12-myristate  (ISO) piperonyl butoxide  (EXP) pirinixic acid  (EXP,ISO) prazosin  (ISO) pregnenolone 16alpha-carbonitrile  (EXP) progesterone  (ISO) propiconazole  (ISO) propranolol  (ISO) pyridoxal 5'-phosphate  (EXP) quercetin  (EXP,ISO) raloxifene  (ISO) resveratrol  (EXP,ISO) rosiglitazone  (EXP,ISO) rotenone  (ISO) S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP) silver atom  (ISO) silver(0)  (ISO) simvastatin  (EXP,ISO) sodium hydrogencarbonate  (EXP) sphingosine 1-phosphate  (EXP) staurosporine  (EXP) streptozocin  (EXP) superoxide  (EXP) tacrolimus hydrate  (ISO) tamoxifen  (ISO) taurine  (ISO) telmisartan  (EXP) tert-butyl hydroperoxide  (ISO) tetrachloromethane  (EXP,ISO) thioacetamide  (ISO) titanium dioxide  (ISO) toluene  (ISO) trans-resveratrol  (EXP,ISO) tributylstannane  (ISO) troglitazone  (ISO) vancomycin  (EXP,ISO) vincaleukoblastine  (ISO) zinc atom  (ISO) zinc(0)  (ISO) Gene Ontology Annotations Biological Process acute-phase response  (IEA) angiogenesis  (IEA) calcium-independent cell-matrix adhesion  (ISO) cell activation  (IMP) cell adhesion  (ISO) cell-matrix adhesion  (IMP,ISO) cell-substrate junction assembly  (ISO) cellular response to BMP stimulus  (IEP) cellular response to glucose stimulus  (IEP) cellular response to interleukin-1  (IMP) cellular response to lipopolysaccharide  (IEP) cellular response to mercury ion  (IDA) cellular response to platelet-derived growth factor stimulus  (IEP) cellular response to prostaglandin E stimulus  (IEP) cellular response to transforming growth factor beta stimulus  (IEP) cellular response to vascular endothelial growth factor stimulus  (IEP) extracellular matrix organization  (IMP) glial cell migration  (IDA) negative regulation of apoptotic process  (IMP) ossification  (TAS) peptide cross-linking  (ISO) positive regulation of cell migration  (IMP) positive regulation of chemotaxis  (IDA) positive regulation of peptidase activity  (ISO) regulation of cell shape  (IEA) response to glucocorticoid stimulus  (IEP) response to ischemia  (IEP) response to ozone  (IEP) response to wounding  (IEP) substrate adhesion-dependent cell spreading  (ISO) wound healing  (ISO) Cellular Component apical plasma membrane  (ISO) basement membrane  (IDA,ISO) endoplasmic reticulum-Golgi intermediate compartment  (ISO) extracellular matrix  (ISO) extracellular region  (IEA) extracellular space  (IDA,ISO) fibrinogen complex  (ISO) proteinaceous extracellular matrix  (ISO,TAS) Molecular Function extracellular matrix structural constituent  (TAS) heparin binding  (IEA) mercury ion binding  (IDA) peptidase activator activity  (ISO) protease binding  (IPI) protein binding  (IPI,ISO) Molecular Pathway Annotations cell-extracellular matrix signaling pathway  (IEA) Entamoeba histolyca infection pathway  (IEA) small cell lung cancer pathway  (IEA) syndecan signaling pathway  (ISO) External Database Links KEGG Pathway Amoebiasis Bacterial invasion of epithelial cells ECM-receptor interaction Focal adhesion Pathways in cancer PI3K-Akt signaling pathway Regulation of actin cytoskeleton Small cell lung cancer Pathway Interaction Database Alpha4 beta1 integrin signaling events (PID:200221) Alpha9 beta1 integrin signaling events (PID:200093) Angiopoietin receptor Tie2-mediated signaling (PID:200079) Beta1 integrin cell surface interactions (PID:200016) Beta3 integrin cell surface interactions (PID:200043) Beta5 beta6 beta7 and beta8 integrin cell surface interactions (PID:200169) Integrins in angiogenesis (PID:200128) Syndecan-2-mediated signaling events (PID:200192) Syndecan-4-mediated signaling events (PID:200134) Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling (PID:200139) VEGFR3 signaling in lymphatic endothelium (PID:200218) Phenotype Annotations abnormal apoptosis  (IEA) References - curated 1. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8. 2. Akkoyunlu G, etal., Acta Histochem. 2003;105(4):295-301. 3. Amersi F, etal., Am J Pathol. 2003 Apr;162(4):1229-39. 4. Arai H, etal., Biol Neonate. 2005;87(2):113-20. Epub 2004 Nov 11. 5. Ayaki M, etal., Biochim Biophys Acta. 2000 Jan 10;1495(1):40-50. 6. Barnes JL, etal., J Histochem Cytochem. 1999 Apr;47(4):533-44. 7. Choung PH, etal., Biochem Biophys Res Commun 2002 Jul 26;295(4):898-902. 8. Comi AM, etal., Pediatr Res 2003 May;53(5):762-9. Epub 2003 Mar 5. 9. Cui C, etal., Clin Exp Pharmacol Physiol. 2007 Apr;34(4):304-9. 10. Eismann U, etal., Nephron. 2002 Oct;92(2):379-88. 11. Eissa S, etal., Med Oncol. 2010 Dec;27(4):1286-94. doi: 10.1007/s12032-009-9375-9. Epub 2009 Dec 11. 12. Eriksen HO, etal., Scand J Clin Lab Invest. 1983 Dec;43(8):723-6. 13. Feng Y, etal., Cell Physiol Biochem. 2005;16(4-6):237-44. 14. Fernandez L and Mosquera JA, Pathobiology. 2002-2003;70(4):191-6. 15. Fujimoto T, etal., Virchows Arch. 2003 Aug;443(2):194-205. Epub 2003 Jul 17. 16. GOA data from the GO Consortium 17. Gupta SK, etal., Am J Physiol. 1998 Aug;275(2 Pt 1):L330-5. 18. Havrlikova K, etal., Cornea. 2004 Nov;23(8):812-8. 19. Hsu CC and Lai SC, Int J Exp Pathol. 2007 Dec;88(6):437-43. 20. Huang K, etal., PLoS One. 2012;7(8):e43874. doi: 10.1371/journal.pone.0043874. Epub 2012 Aug 24. 21. Idasiak-Piechocka I, etal., Nephron Clin Pract. 2010;116(1):c47-52. doi: 10.1159/000314550. Epub 2010 May 12. 22. Jarnagin WR, etal., J Cell Biol. 1994 Dec;127(6 Pt 2):2037-48. 23. Jia JB, etal., World J Gastroenterol. 1998 Aug;4(4):329-331. 24. Jiang T, etal., Nephrology (Carlton). 2006 Apr;11(2):105-12. 25. Kanters SD, etal., Diabetes Care. 2001 Feb;24(2):323-7. 26. Kim MS, etal., Yonsei Med J. 2004 Dec 31;45(6):1121-6. 27. King VR, etal., Neuroscience. 2010 Jun 30;168(2):523-30. doi: 10.1016/j.neuroscience.2010.03.040. Epub 2010 Mar 25. 28. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 29. Lee BH, etal., Biochem Biophys Res Commun 2002 Oct 11;297(5):1218-24. 30. Mattii L, etal., Nephron Exp Nephrol. 2005;101(1):e16-23. Epub 2005 May 27. 31. McElroy MC, etal., Infect Immun. 2002 Jul;70(7):3865-73. 32. MGD data from the GO Consortium 33. Mortell A, etal., Pediatr Surg Int. 2004 Apr;20(4):276-82. Epub 2004 Feb 18. 34. NCBI rat LocusLink and RefSeq merged data July 26, 2002 35. Nezi L, etal., Biol Chem 2002 Jan;383(1):167-76. 36. Onaran M, etal., Urology. 2009 Nov;74(5):1004-7. doi: 10.1016/j.urology.2009.05.010. Epub 2009 Jul 17. 37. Online Mendelian Inheritance in Man, OMIM (TM). 38. Petrini G, etal., Mol Cell Biochem. 2002 Dec;241(1-2):21-7. 39. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 40. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 41. RGD automated import pipeline for gene-chemical interactions 42. RGD Automated Pipelines 43. Roy S, etal., Diabetes. 2003 May;52(5):1229-34. 44. Saball E, etal., Mol Cell Biochem 2001 Oct;226(1-2):67-75. 45. Schwarzbauer JE, etal., Cell 1983 Dec;35(2 Pt 1):421-31. 46. Schwarzbauer JE, etal., EMBO J 1987 Sep;6(9):2573-80. 47. Shiota S, etal., Biol Pharm Bull. 2001 Jul;24(7):835-7. 48. Sottile J and Hocking DC, Mol Biol Cell 2002 Oct;13(10):3546-59. 49. Tang CH, etal., J Biol Chem. 2005 Jun 17;280(24):22907-16. Epub 2005 Apr 15. 50. Tang CH, etal., J Bone Miner Res. 2003 Mar;18(3):502-11. 51. Tsujihata M, etal., J Urol. 2000 Nov;164(5):1718-23. 52. Ueda K, etal., Int J Oral Maxillofac Surg. 2009 Jan;38(1):79-84. doi: 10.1016/j.ijom.2008.11.004. Epub 2008 Dec 18. 53. Waalkes S, etal., BMC Cancer. 2010 Sep 22;10:503. doi: 10.1186/1471-2407-10-503. 54. Wang XL, etal., Cell Mol Neurobiol. 2009 Jun;29(4):549-56. Epub 2009 Jan 27. 55. Wu D, etal., J Am Soc Nephrol. 2005 Mar;16(3):646-57. Epub 2005 Jan 26. 56. Wu TT, etal., Am J Physiol Renal Physiol. 2012 Dec 26. 57. Xie X, etal., Mol Cell Endocrinol. 2012 Oct 15;362(1-2):183-93. doi: 10.1016/j.mce.2012.06.008. Epub 2012 Jun 22. 58. Yang D, etal., Biochem Biophys Res Commun. 2009 Oct 23;388(3):606-11. Epub 2009 Aug 18. 59. Yoneda A, etal., Mol Biol Cell. 2007 Jan;18(1):66-75. Epub 2006 Oct 25. 60. Zuk A, etal., Am J Physiol Renal Physiol. 2001 Jun;280(6):F1037-53. References - uncurated PubMed 10640397   11914376   12160302   14587027   15068706   15604136   15677465   16159961   16316526   16534777   16572112   17021600   17252537   17609505   17715430   17953369   18379124   19366727   19546347   19607919   20049771   20380796   20810141   21098642   21099277   21141136   21586275   21613793   21940672   22759963   22812390   22900368   22904348   3119323   3863113   6089177   7519849   9632774 RGD Disease Portals Fn1 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Biological Process Diabetes Diseases Diabetes Pathways Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Biological Process Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Biological Process Respiratory Diseases Respiratory Pathways Genomics Comparative Map Data Fn1   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 9 q33   NCBI RGSC Genome Assembly v5.0 9 78,674,439 - 78,743,407 - NCBI RGSC Genome Assembly v3.4 9 70,702,181 - 70,771,155 - NCBI Rat Celera Assembly 9 70,607,233 - 70,675,716 - NCBI Genome Assembly 3.1 9 70,849,162 - 70,918,137 - NCBI RH 3.4 9 673.9   RGD FN1   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 2 215,610,957 - 215,686,546 - NCBI Human Genome Assembly HuRef 2 208,082,209 - 208,158,070 - NCBI Human Genome Assembly GRCh37 2 216,225,177 - 216,300,791 - NCBI Human Genome Assembly Build 36 2 215,933,422 - 216,009,036 - NCBI Human Cytogenetic Map 2 q34   NCBI Human Genome Assembly 2 216,050,686 - 216,126,297   NCBI Fn1   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 1 71,585,523 - 71,653,171 - NCBI Mouse cM Map 1 36.05   NCBI Mouse Celera Assembly 1 72,141,007 - 72,208,976 - NCBI Mouse Genome Assembly Build 37 1 71,632,097 - 71,699,745 - NCBI Mouse Genome Assembly Build 36.1 1 71,632,097 - 71,699,745 - NCBI Mouse Cytogenetic Map 1 C1-C5   NCBI Position Markers PMC151804P1   Map Chr Position Strand Source Rat Cytogenetic Map 9 q33   UniSTS RGSC Genome Assembly v5.0 9 78,674,658 - 78,675,054   UniSTS RGSC Genome Assembly v3.4 9 70,702,400 - 70,702,796   UniSTS Rat Celera Assembly 9 70,607,452 - 70,607,848   UniSTS FN1   Map Chr Position Strand Source Rat Cytogenetic Map 9 q33   UniSTS RGSC Genome Assembly v5.0 9 78,686,008 - 78,686,357   UniSTS RGSC Genome Assembly v3.4 9 70,713,750 - 70,714,099   UniSTS Rat Celera Assembly 9 70,618,802 - 70,619,151   UniSTS RH127568   Map Chr Position Strand Source Rat Cytogenetic Map 9 q33   UniSTS RGSC Genome Assembly v5.0 9 78,674,639 - 78,674,828   UniSTS RGSC Genome Assembly v3.4 9 70,702,381 - 70,702,570   UniSTS Rat Celera Assembly 9 70,607,433 - 70,607,622   UniSTS RH 3.4 9 677.79   UniSTS PMC151804P2   Map Chr Position Strand Source Rat Cytogenetic Map 9 q33   UniSTS RGSC Genome Assembly v5.0 9 78,674,727 - 78,675,027   UniSTS RGSC Genome Assembly v3.4 9 70,702,469 - 70,702,769   UniSTS Rat Celera Assembly 9 70,607,521 - 70,607,821   UniSTS RH139076   Map Chr Position Strand Source Rat Cytogenetic Map 9 q33   UniSTS RGSC Genome Assembly v5.0 9 78,711,194 - 78,711,437   UniSTS RGSC Genome Assembly v3.4 9 70,738,950 - 70,739,193   UniSTS Rat Celera Assembly 9 70,643,875 - 70,644,118   UniSTS RH 3.4 9 670.0   UniSTS QTLs in Region (RGSC Genome Assembly v3.4) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 2303170 Bp332 Blood pressure QTL 332 3.73 .027 Blood pressure 9 1526958 74813097 Rat 70186 Niddm26 Non-insulin dependent diabetes mellitus QTL 26 3.87 Glucose level postprandial 9 18347567 84432994 Rat 7207814 Bmd91 Bone mineral density QTL 91 3.5 Bone mineral density Femur neck cross-sectional total area 9 20102447 81885455 Rat 70218 Cm28 Cardiac mass QTL 28 8.3 .0001 Cardiac mass salt-loaded 9 21667066 77171049 Rat 724544 Uae9 Urinary albumin excretion QTL 9 4.5 Renal function urine albumin level 9 21667066 105580061 Rat 731164 Uae25 Urinary albumin excretion QTL 25 3.5 .0001 Renal function urine albumin level 9 22066101 99799902 Rat 1598834 Memor11 Memory QTL 11 2.5 Memory navigation-spatial 9 33496794 75633613 Rat 2290450 Scl57 Serum cholesterol level QTL 57 4.15 Lipid level cholesterol level 9 33496794 94217673 Rat 61352 Bp34 Blood pressure QTL 34 5 Blood pressure salt-loaded systolic 9 39390033 77170797 Rat 6903937 Bp356 Blood pressure QTL 356 .001 Blood pressure salt-loaded 9 44842118 89842118 Rat 631656 Bp108 Blood pressure QTL 108 5.97 .0001 Blood pressure salt-loaded systolic 9 45992963 90992963 Rat 2303180 Bp333 Blood pressure QTL 333 3.7 .001 Blood pressure salt-loaded systolic 9 53933135 76456066 Rat 724515 Uae16 Urinary albumin excretion QTL 16 8 Renal function urine albumin level 9 55476135 99799760 Rat 1300134 Bp185 Blood pressure QTL 185 3.73 Blood pressure salt-loaded mean arterial 9 58516719 103918256 Rat 1578757 Pur6 Proteinuria QTL 6 3.3 .005 Renal function urine protein level 9 59247346 105580061 Rat 731171 Glom6 Glomerulus QTL 6 2.8 .0003 Renal histology 9 62686917 107686917 Rat Sequence Nucleotide Sequences Nucleotide RefSeqs NM_019143 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AABR06061011 (Get FASTA) Search GEO for Microarray Profiles   AABR06061012 (Get FASTA) Search GEO for Microarray Profiles   AAHX01060748 (Get FASTA) Search GEO for Microarray Profiles   AAHX01060749 (Get FASTA) Search GEO for Microarray Profiles   AF061156 (Get FASTA) Search GEO for Microarray Profiles   CH474044 (Get FASTA) Search GEO for Microarray Profiles   L29191 (Get FASTA) Search GEO for Microarray Profiles   M28258 (Get FASTA) Search GEO for Microarray Profiles   M28259 (Get FASTA) Search GEO for Microarray Profiles   U75410 (Get FASTA) Search GEO for Microarray Profiles   U82612 (Get FASTA) Search GEO for Microarray Profiles   X15906 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_019143 RefSeq Status: VALIDATED Type: CODING Protein Acc Id: NP_062016 Peptide Label: precursor Position: Map Chr Position Strand Source RGSC Genome Assembly v5.0 9 78,674,439 - 78,743,407 - NCBI RGSC Genome Assembly v3.4 9 70,702,181 - 70,771,155 - RGD Rat Celera Assembly 9 70,607,233 - 70,675,716 - RGD Protein Sequences Protein RefSeqs NP_062016 (Get FASTA) GenBank Protein AAA41166 (Get FASTA)   AAA41167 (Get FASTA)   AAA41169 (Get FASTA)   AAB19112 (Get FASTA)   AAB40865 (Get FASTA)   CAA34020 (Get FASTA)   EDL75259 (Get FASTA)   EDL75260 (Get FASTA)   EDL75261 (Get FASTA)   EDL75262 (Get FASTA)   EDL75263 (Get FASTA)   P04937 (Get FASTA) Promoters RGD ID: 6849516 Promoter ID: EP17049 Type: single initiation site Name: RN_FINC Description: Fibronectin, FN1 gene. SO ACC ID: SO:0000170 Source: EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Notes: homology_group=Homology group 110; Mammalian fibronectin Experiment Methods: Nuclease protection Regulation: many cell types; (induced by or strongly expressed in) acute phase Position: Map Chr Position Strand Source RGSC Genome Assembly v3.4 9 70,771,155 - 70,771,215   EPD Strain Variation Strain Sequence Variants ACI/Eur (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 ACI/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN-Lx (ICL) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: SOLID Secondary Analysis: BWA, GATK, Samtools Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: MC-A654-5QB00 BN-Lx (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/NHsdMcwi (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/SsN (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Buf/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) COP/Crl (MCW & UW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Univiersity of Wisconsin (Jim Shull) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 Breeder: Charles River Grant Information: NIH (CA77876) F344/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHH/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 FHH/EurMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHL/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 GH/OmrMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 LE/Stm (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Dr. Tadao Serikawa, Kyoto Japan. Grant Information: EURATRANS (HEALTH-F4-2010-241504) M520/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) MR/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHR/Olalpcv (ICL) Visual CSV TAB Printer Sequenced By: Imperial College London (Dr Timothy Aitman) University of British Columbia (Dr. Steven Jones) Platform: Illumina Hi-seq 2000 and GAII Secondary Analysis: BWA, GATK Breeder: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague Grant Information: LSHG-CT-2005-019015, HEALTH-F4-2010-241504 SHR/Olalpcv (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: Illumina Secondary Analysis: GATK Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHRSP/Gcrc (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruch Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: University of Glasgow, Anna Dominiczak Grant Information: EURATRANS (HEALTH-F4-2010-241504) SR/JrHsd (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Breeder: Harlan SS/JrHsdMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Grant Information: R01 HL089930 SS/JrHsdMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) WKY/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) WN/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSRNOG00000014288 UniProtKB/TrEMBL Ensembl Protein ENSRNOP00000019772 UniProtKB/TrEMBL   ENSRNOP00000054395 UniProtKB/TrEMBL Ensembl Transcript ENSRNOT00000019772 UniProtKB/TrEMBL   ENSRNOT00000057585 UniProtKB/TrEMBL Entrez Gene 25661 ENTREZGENE Gene3D-CATH Complement_control_module UniProtKB/Swiss-Prot Germonline ENSRNOG00000014288 UniProtKB/Swiss-Prot HomoloGene Group ID 1533 ENTREZGENE InterPro Fibrnctn1 UniProtKB/Swiss-Prot   FN_III UniProtKB/Swiss-Prot   FN_type2_col_bd UniProtKB/Swiss-Prot   Ig-like_fold UniProtKB/Swiss-Prot   Kringle-like UniProtKB/Swiss-Prot IPI IPI00200757 UniProtKB/Swiss-Prot   IPI00208859 UniProtKB/TrEMBL   IPI00231982 UniProtKB/Swiss-Prot   IPI00231983 UniProtKB/Swiss-Prot   IPI00231984 UniProtKB/Swiss-Prot KEGG Report rno:25661 ENTREZGENE, UniProtKB/TrEMBL Pfam fn1 UniProtKB/Swiss-Prot   fn2 UniProtKB/Swiss-Prot   fn3 UniProtKB/Swiss-Prot PROSITE EGF_1 UniProtKB/Swiss-Prot   FN1_1 UniProtKB/Swiss-Prot   FN1_2 UniProtKB/Swiss-Prot   FN2_1 UniProtKB/Swiss-Prot   FN2_2 UniProtKB/Swiss-Prot   FN3 UniProtKB/Swiss-Prot SMART FN1 UniProtKB/Swiss-Prot   FN2 UniProtKB/Swiss-Prot   FN3 UniProtKB/Swiss-Prot Superfamily-SCOP FN_III-like UniProtKB/Swiss-Prot   Kringle-like UniProtKB/Swiss-Prot UniGene Rn.1604 ENTREZGENE UniProt F1LST1_RAT UniProtKB/TrEMBL   FINC_RAT UniProtKB/Swiss-Prot   G3V7W2_RAT UniProtKB/TrEMBL   Q9Z1G8_RAT UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2002-06-10 Fn1  Fibronectin 1      Symbol and Name status set to approved 1490 APPROVED RGD Curation Notes Note Type Note Reference gene_disease fibrotic deposits are detected in the kidneys in mercuric chloride induced renal failure 729934

More on Fn1 Entrez Gene Ensembl Gene Genome Browser NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 2624 Created: 2000-05-25 Species: Rattus norvegicus Last Modified: 2013-04-16 Status: ACTIVE