Gene: Ins2 (insulin 2)  Rattus norvegicus Symbol: Ins2 Name: insulin 2 Description: ENCODES a protein that exhibits protease binding; protein complex binding; hormone activity (ortholog); INVOLVED IN activation of MAPK activity (ortholog); activation of protein kinase B activity (ortholog); acute-phase response (ortholog); PARTICIPATES IN altered insulin signaling pathway; forkhead class A signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; ASSOCIATED WITH Alzheimer Disease; Diabetic Nephropathies; Hypertension; FOUND IN extracellular space; secretory granule; cytoplasm (ortholog); INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,6-dinitrotoluene Type: protein-coding RefSeq Status: VALIDATED Also known as: insulin 2; insulin-2 Orthologs: Homo sapiens : INS (insulin)  HGNC Mus musculus : Ins2 (insulin II)  MGI Latest Assembly: RGSC Genome Assembly v3.4 Position: Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   NCBI RGSC Genome Assembly v5.0 1 222,751,786 - 222,752,853 - NCBI RGSC Genome Assembly v3.4 1 202,935,548 - 202,936,379 - NCBI Rat Celera Assembly 1 195,461,309 - 195,462,376 - NCBI Genome Assembly 3.1 1 203,123,613 - 203,124,445 - NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Adenoma   ISS RGD:10812 2317273 protein:increased secretion:serum RGD   Alzheimer Disease   IEP   2298713 mRNA:decreased expression:cerebral cortex RGD   Carcinoma, Pancreatic Ductal   ISS RGD:731056 2317248 Glucagon/insulin RGD   Diabetes Mellitus   ISS RGD:731056 2311109   RGD   Diabetes Mellitus   ISS RGD:731056 2317260 protein:altered localization :endoplasmic reticulum RGD   Diabetes Mellitus   ISS RGD:731056 2317262 DNA, protein:missense mutations, altered processing:exons, endoplasmic reticulum:multiple RGD   Diabetes Mellitus   ISS RGD:731056 2317259 DNA, protein:missense mutations:exons:multiple RGD   Diabetes Mellitus   ISS RGD:10812 2311115 DNA:point mutation (mouse) RGD   Diabetes Mellitus, Permanent Neonatal   ISS RGD:731056 7240710   OMIM   Diabetes Mellitus, Type 1   ISS RGD:731056 2311114   RGD   Diabetes Mellitus, Type 2   ISS RGD:731056 1625120   RGD   Diabetes Mellitus, Type 2   ISS RGD:731056 2311111   RGD   Diabetes Mellitus, Type 2   ISS RGD:731056 2311112   RGD   Diabetes, Gestational   ISS RGD:731056 2311131 protein:increased expression:serum RGD   Diabetic Nephropathies Resistance IED   6902908   RGD   Diabetic Retinopathy   ISS RGD:731056 6902909   RGD   Fatty Liver   ISS RGD:731056 2311137 associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD   Hyperinsulinism   ISS RGD:731056 1625121   RGD   Hyperinsulinism   ISS RGD:731056 7240710   OMIM   Hypertension   IED   6902896   RGD   Hyperuricemia   ISS RGD:731056 6902897   RGD   Insulin Resistance   ISS RGD:731056 2311112   RGD   Insulinoma   ISS RGD:731056 2317266 protein:altered expression:blood RGD   Insulinoma   ISS RGD:731056 2317268 protein:altered localization:pancreas RGD   MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 10   ISS RGD:731056 7240710   OMIM   Obesity   ISS RGD:731056 1625118   RGD   Pancreatic Neoplasms Susceptibility ISS RGD:731056 2317250 associated with Diabetes Mellitus RGD   Pancreatic Neoplasms Disease_progression ISS RGD:731056 2317253 DNA:Polymorphism:promoter:-23 HphI (human) RGD   Pancreatic Neoplasms Susceptibility ISS RGD:731056 2317247 associated with Diabetes Mellitus, Non-Insulin-Depend RGD   Pancreatic Neoplasms   ISS RGD:10812 2317245   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (R)-adrenaline multiple interactions ISO RGD:731056 6480464 Butoxamine inhibits the reaction [Epinephrine results in decreased expression of INS protein]; more ... CTD PMID:6018752 (R)-adrenaline decreases expression ISO RGD:731056 6480464 Epinephrine results in decreased expression of INS protein CTD PMID:6018752 PMID:6314140 (R)-adrenaline multiple interactions ISO RGD:731056 6480464 Pentolinium Tartrate inhibits the reaction [Epinephrine results in decreased secretion of INS protein] CTD PMID:1218171 (R)-adrenaline decreases expression ISO RGD:731056 6480464 Epinephrine results in decreased expression of INS protein CTD PMID:6314140 PMID:6018752 (R)-lipoic acid multiple interactions ISO RGD:731056 6480464 Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 (S)-nicotine increases expression EXP   6480464 Nicotine results in increased expression of INS2 mRNA CTD PMID:20426880 17beta-estradiol multiple interactions ISO RGD:731056 6480464 Estradiol promotes the reaction [INS protein results in increased chemical synthesis of Glycogen]; more ... CTD PMID:21632903 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of INS2 mRNA CTD PMID:18446233 17beta-estradiol increases expression ISO RGD:10812 6480464 Estradiol results in increased expression of INS2 protein CTD PMID:18446233 17beta-estradiol multiple interactions ISO RGD:10812 6480464 ESR1 protein affects the reaction [Estradiol results in increased expression of INS2 protein]; more ... CTD PMID:18446233 2,6-dinitrotoluene affects expression EXP   6480464 2,6-dinitrotoluene affects the expression of INS2 mRNA CTD PMID:21346803 2-amino-2-deoxy-D-glucopyranose multiple interactions ISO RGD:731056 6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; more ... CTD PMID:20165829 2-deoxy-D-glucose multiple interactions ISO RGD:731056 6480464 SLC2A1 protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose] CTD PMID:2173694 2-deoxy-D-glucose multiple interactions ISO RGD:10812 6480464 PPARA protein promotes the reaction [GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]] CTD PMID:21324916 2-deoxy-D-glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Deoxyglucose CTD PMID:16483873 PMID:21324916 2-deoxy-D-glucose multiple interactions ISO RGD:731056 6480464 GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose] CTD PMID:21324916 2-deoxy-D-glucose multiple interactions ISO RGD:731056 6480464 TNF protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; more ... CTD PMID:16483873 2-deoxy-D-glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Deoxyglucose CTD PMID:16483873 2-deoxy-D-glucose increases uptake ISO RGD:731056 6480464 INS results in increased uptake of Deoxyglucose CTD PMID:20165829 2-deoxy-D-glucose multiple interactions ISO RGD:731056 6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; more ... CTD PMID:20165829 3-aminobenzamide multiple interactions ISO RGD:731056 6480464 3-aminobenzamide inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]; more ... CTD PMID:16505238 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:10812 6480464 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPA mRNA]; more ... CTD PMID:22298784 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:731056 6480464 BQ 610 affects the reaction [sodium arsenite inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]]; more ... CTD PMID:23152186 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:731056 6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of ADIPOQ mRNA; more ... CTD PMID:23086663 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:10812 6480464 bisphenol A inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; more ... CTD PMID:22197818 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP   6480464 [INS co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in decreased expression of SOX2 mRNA; more ... CTD PMID:21350315 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:731056 6480464 [rosiglitazone co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA; more ... CTD PMID:20206132 4-phenylbutyric acid multiple interactions ISO RGD:731056 6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]] CTD PMID:20165829 5-fluorouracil decreases expression ISO RGD:10812 6480464 Fluorouracil results in decreased expression of INS2 protein CTD PMID:21296659 AACOCF3 increases secretion ISO RGD:731056 6480464 arachidonyltrifluoromethane results in increased secretion of INS protein CTD PMID:17192482 AACOCF3 multiple interactions ISO RGD:731056 6480464 arachidonyltrifluoromethane inhibits the reaction [Glucose results in increased secretion of INS protein] CTD PMID:17192482 acetic acid decreases expression ISO RGD:10812 6480464 Acetic Acid results in decreased expression of INS2 protein CTD PMID:21296659 albuterol increases expression ISO RGD:731056 6480464 Albuterol results in increased expression of INS CTD PMID:8098220 albuterol increases expression ISO RGD:731056 6480464 Albuterol results in increased expression of INS protein CTD PMID:9088585 aldehydo-D-glucosamine multiple interactions ISO RGD:731056 6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; more ... CTD PMID:20165829 all-trans-retinoic acid increases expression ISO RGD:731056 6480464 Tretinoin results in increased expression of INS protein CTD PMID:16473924 all-trans-retinoic acid increases secretion ISO RGD:731056 6480464 Tretinoin results in increased secretion of INS protein CTD PMID:16473924 all-trans-retinol multiple interactions ISO RGD:10812 6480464 [Vitamin A co-treated with INHBA protein] results in increased expression of INS2 mRNA CTD PMID:17244017 amlodipine decreases expression ISO RGD:731056 6480464 Amlodipine results in decreased expression of INS protein CTD PMID:19651449 ammonium chloride affects expression EXP   6480464 Ammonium Chloride affects the expression of INS2 mRNA CTD PMID:16483693 arachidonic acid multiple interactions ISO RGD:731056 6480464 Arachidonic Acid promotes the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:17192482 arachidonic acid increases secretion ISO RGD:731056 6480464 Arachidonic Acid results in increased secretion of INS protein CTD PMID:17192482 aspartame increases expression ISO RGD:731056 6480464 Aspartame results in increased expression of INS protein CTD PMID:1805284 atenolol multiple interactions ISO RGD:731056 6480464 Atenolol inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:12795776 baicalein multiple interactions ISO RGD:731056 6480464 baicalein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:17192482 baicalein increases secretion ISO RGD:731056 6480464 baicalein results in increased secretion of INS protein CTD PMID:17192482 beta-D-glucosamine multiple interactions ISO RGD:731056 6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; more ... CTD PMID:20165829 bezafibrate multiple interactions ISO RGD:731056 6480464 [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased expression of INS protein CTD PMID:20404010 bezafibrate decreases expression ISO RGD:731056 6480464 Bezafibrate results in decreased expression of INS protein CTD PMID:2209320 bezafibrate multiple interactions ISO RGD:731056 6480464 Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]; more ... CTD PMID:11292061 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:10812 6480464 Diethylhexyl Phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; more ... CTD PMID:22197818 bisoprolol multiple interactions ISO RGD:731056 6480464 Bisoprolol inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:12795776 bisphenol A multiple interactions ISO RGD:10812 6480464 bisphenol A inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; more ... CTD PMID:22197818 bisphenol A decreases expression EXP   6480464 bisphenol A results in decreased expression of INS2 mRNA CTD PMID:23328667 bisphenol A multiple interactions ISO RGD:10812 6480464 ESR1 protein affects the reaction [bisphenol A results in increased expression of INS2 protein]; more ... CTD PMID:18446233 bisphenol A increases expression ISO RGD:10812 6480464 bisphenol A results in increased expression of INS2 protein CTD PMID:18446233 bisphenol A increases secretion ISO RGD:731056 6480464 bisphenol A results in increased secretion of INS protein CTD PMID:22347437 bromochloroacetic acid decreases expression ISO RGD:10812 6480464 bromochloroacetic acid results in decreased expression of INS2 protein CTD PMID:21296659 bromocriptine decreases expression ISO RGD:731056 6480464 Bromocriptine results in decreased expression of INS protein CTD PMID:16803851 cadmium atom decreases expression ISO RGD:731056 6480464 Cadmium results in decreased expression of INS protein CTD PMID:17303580 caffeine multiple interactions ISO RGD:731056 6480464 Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:21081844 capsaicin multiple interactions EXP   6480464 [INS protein co-treated with Capsaicin] promotes the reaction [Capsaicin results in increased uptake of cobaltous chloride] CTD PMID:14622148 carvedilol decreases expression ISO RGD:731056 6480464 carvedilol results in decreased expression of INS protein alternative form CTD PMID:16598518 chlorpropamide decreases expression ISO RGD:731056 6480464 Chlorpropamide results in decreased expression of INS protein CTD PMID:15642492 chlorpropamide increases expression ISO RGD:731056 6480464 Chlorpropamide results in increased expression of INS mRNA CTD PMID:15642492 chlorpropamide multiple interactions ISO RGD:731056 6480464 Chlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein] CTD PMID:15642492 ciprofibrate multiple interactions EXP   6480464 INS protein affects the reaction [ciprofibrate results in increased expression of CYP3A1 mRNA] CTD PMID:10215695 clofibrate affects secretion ISO RGD:731056 6480464 Clofibrate affects the secretion of INS protein CTD PMID:1143089 clofibrate decreases secretion ISO RGD:731056 6480464 Clofibrate results in decreased secretion of INS protein CTD PMID:417937 clonidine decreases secretion ISO RGD:731056 6480464 Clonidine results in decreased secretion of INS protein CTD PMID:707001 clonidine (amino form) decreases secretion ISO RGD:731056 6480464 Clonidine results in decreased secretion of INS protein CTD PMID:707001 clonidine (imino form) decreases secretion ISO RGD:731056 6480464 Clonidine results in decreased secretion of INS protein CTD PMID:707001 clozapine affects secretion ISO RGD:731056 6480464 Clozapine affects the secretion of INS protein CTD PMID:11769361 clozapine increases expression ISO RGD:731056 6480464 Clozapine results in increased expression of INS protein CTD PMID:16601995 co-trimoxazole increases secretion ISO RGD:731056 6480464 Trimethoprim-Sulfamethoxazole Combination results in increased secretion of INS protein modified form CTD PMID:14714756 cobalt dichloride multiple interactions EXP   6480464 Ruthenium Red inhibits the reaction [INS protein results in increased uptake of cobaltous chloride]; more ... CTD PMID:14622148 cobalt dichloride increases uptake EXP   6480464 INS protein results in increased uptake of cobaltous chloride CTD PMID:14622148 cocaine decreases expression ISO RGD:731056 6480464 Cocaine results in decreased expression of INS protein CTD PMID:18346162 copper atom multiple interactions ISO RGD:731056 6480464 INS protein inhibits the reaction [ATP7B protein affects the export of Copper] CTD PMID:17109627 copper atom affects transport ISO RGD:731056 6480464 INS protein affects the transport of Copper CTD PMID:17109627 copper(0) affects transport ISO RGD:731056 6480464 INS protein affects the transport of Copper CTD PMID:17109627 copper(0) multiple interactions ISO RGD:731056 6480464 INS protein inhibits the reaction [ATP7B protein affects the export of Copper] CTD PMID:17109627 corticotropin multiple interactions ISO RGD:731056 6480464 Adrenocorticotropic Hormone inhibits the reaction [INS protein results in increased secretion of GH1 protein] CTD PMID:3008584 cortisol increases expression ISO RGD:731056 6480464 Hydrocortisone results in increased expression of INS protein CTD PMID:7917157 more ... cortisol increases expression ISO RGD:731056 6480464 Hydrocortisone results in increased expression of INS protein CTD PMID:7473517 more ... cortisol increases expression ISO RGD:731056 6480464 Hydrocortisone results in increased expression of INS protein CTD PMID:7792821 more ... cortisol increases expression ISO RGD:731056 6480464 Hydrocortisone results in increased expression of INS protein CTD PMID:7917157 more ... cortisol multiple interactions ISO RGD:731056 6480464 Octreotide inhibits the reaction [Hydrocortisone results in increased expression of INS protein] CTD PMID:7917157 PMID:7792821 cortisol increases expression ISO RGD:731056 6480464 Hydrocortisone results in increased expression of INS protein CTD PMID:7473517 more ... cortisol multiple interactions ISO RGD:731056 6480464 Octreotide inhibits the reaction [Hydrocortisone results in increased expression of INS protein] CTD PMID:7792821 PMID:7917157 D-glucose multiple interactions ISO RGD:10812 6480464 Estradiol promotes the reaction [Glucose results in increased secretion of INS2 protein] CTD PMID:18446233 D-glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:18266981 D-glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... D-glucose multiple interactions ISO RGD:731056 6480464 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]] CTD PMID:21163946 D-glucose multiple interactions ISO RGD:10812 6480464 IL1B protein inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]; more ... CTD PMID:22558381 D-glucose multiple interactions ISO RGD:731056 6480464 UCP3 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:18167556 D-glucose multiple interactions EXP   6480464 IKBKB affects the reaction [IL1B protein inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]]; more ... CTD PMID:22558381 D-glucose increases expression EXP   6480464 Glucose results in increased expression of INS2 mRNA alternative form CTD PMID:22558381 D-glucose increases expression ISO RGD:10812 6480464 Glucose results in increased expression of INS2 mRNA alternative form CTD PMID:22558381 D-glucose multiple interactions ISO RGD:731056 6480464 MIR133A affects the reaction [Glucose results in decreased chemical synthesis of INS protein] CTD PMID:20520763 D-glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... D-glucose decreases chemical synthesis ISO RGD:731056 6480464 Glucose results in decreased chemical synthesis of INS protein CTD PMID:20520763 D-glucose multiple interactions ISO RGD:731056 6480464 INS protein inhibits the reaction [Glucose results in decreased expression of ATP1A1 protein] CTD PMID:22162761 D-glucose multiple interactions ISO RGD:731056 6480464 GW8510 promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:22242153 D-glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... D-glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:838844 more ... D-glucose multiple interactions ISO RGD:731056 6480464 Metformin promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:15531508 D-glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Glucose CTD PMID:18328801 more ... D-glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Glucose CTD PMID:19531641 more ... D-glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:19188863 more ... D-glucose multiple interactions EXP   6480464 Acetylcysteine inhibits the reaction [Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS protein]] CTD PMID:21888768 D-glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Glucose CTD PMID:15277403 more ... D-glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:18347054 more ... D-glucose decreases secretion ISO RGD:731056 6480464 Glucose results in decreased secretion of INS protein CTD PMID:15642492 PMID:16452552 D-glucose multiple interactions ISO RGD:731056 6480464 TNF protein inhibits the reaction [INS protein results in increased uptake of Glucose]; more ... CTD PMID:7956951 D-glucose multiple interactions ISO RGD:731056 6480464 rosiglitazone promotes the reaction [INS protein results in increased uptake of Glucose] CTD PMID:15277403 D-glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Glucose CTD PMID:19531641 more ... D-glucose increases secretion ISO RGD:731056 6480464 INS protein results in increased secretion of Glucose CTD PMID:14625208 D-glucose multiple interactions ISO RGD:731056 6480464 IAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:16204373 D-glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:15153144 more ... D-glucose increases activity ISO RGD:731056 6480464 Glucose results in increased activity of INS promoter CTD PMID:16489446 D-glucose decreases secretion ISO RGD:731056 6480464 Glucose results in decreased secretion of INS protein CTD PMID:16452552 PMID:15642492 D-glucose multiple interactions ISO RGD:731056 6480464 Glucose inhibits the reaction [INS protein results in increased chemical synthesis of Glycogen] CTD PMID:15864539 D-glucose multiple interactions ISO RGD:731056 6480464 Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein] CTD PMID:16452552 D-glucose multiple interactions ISO RGD:731056 6480464 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]]; more ... CTD PMID:14625208 D-glucose decreases expression EXP   6480464 Glucose results in decreased expression of INS2 mRNA CTD PMID:12914525 D-glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Glucose CTD PMID:19531641 PMID:18328801 D-glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:838844 more ... D-glucose increases expression EXP   6480464 Glucose results in increased expression of INS mRNA CTD PMID:9142872 D-glucose increases secretion ISO RGD:10812 6480464 Glucose results in increased secretion of INS protein CTD PMID:10967106 D-glucose multiple interactions ISO RGD:10812 6480464 [IL1B protein co-treated with IFNG protein] promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:10967106 D-glucose multiple interactions ISO RGD:731056 6480464 SLC30A8 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:16984975 D-glucose multiple interactions ISO RGD:731056 6480464 Saquinavir inhibits the reaction [INS protein results in increased import of Glucose] CTD PMID:11786383 D-glucose multiple interactions ISO RGD:731056 6480464 NKX6-1 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:18347054 D-glucose multiple interactions ISO RGD:731056 6480464 IRS1 protein polymorphism inhibits the reaction [Glucose results in increased secretion of INS protein] CTD PMID:10430617 D-glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Glucose CTD PMID:18328801 D-glucose multiple interactions ISO RGD:731056 6480464 INS protein mutant form results in decreased uptake of and results in decreased oxidation of Glucose CTD PMID:3511099 D-glucose decreases secretion ISO RGD:731056 6480464 Glucose results in decreased secretion of INS protein CTD PMID:15642492 D-glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... D-glucose multiple interactions ISO RGD:731056 6480464 [Glyburide co-treated with Glucose] results in increased expression of INS protein CTD PMID:11305519 D-glucose multiple interactions ISO RGD:731056 6480464 [Glucose co-treated with sodium arsenite] results in increased secretion of INS protein; more ... CTD PMID:20100676 D-glucose multiple interactions ISO RGD:731056 6480464 Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]; more ... CTD PMID:20960276 D-glucose multiple interactions ISO RGD:731056 6480464 [Glucose co-treated with INS protein] affects the localization of PDX1 protein; more ... CTD PMID:11574405 D-glucose multiple interactions ISO RGD:731056 6480464 Dexamethasone inhibits the reaction [INS protein results in increased uptake of Glucose] CTD PMID:18328801 D-glucose multiple interactions ISO RGD:731056 6480464 Chlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein]; more ... CTD PMID:15642492 D-glucose multiple interactions ISO RGD:731056 6480464 alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol promotes the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:17192482 D-glucose multiple interactions ISO RGD:731056 6480464 3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose results in increased expression of INS mRNA]; more ... CTD PMID:16505238 D-glucose increases secretion ISO RGD:10812 6480464 Glucose results in increased secretion of INS2 protein CTD PMID:18446233 demethoxycurcumin increases secretion ISO RGD:731056 6480464 demethoxycurcumin results in increased secretion of INS protein CTD PMID:19188863 dexamethasone multiple interactions ISO RGD:10812 6480464 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPA mRNA]; more ... CTD PMID:22298784 dexamethasone multiple interactions ISO RGD:731056 6480464 BQ 610 affects the reaction [sodium arsenite inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]]; more ... CTD PMID:23152186 dexamethasone multiple interactions ISO RGD:731056 6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of ADIPOQ mRNA; more ... CTD PMID:23086663 dexamethasone multiple interactions ISO RGD:10812 6480464 [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in decreased expression of BAX protein; more ... CTD PMID:11751460 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:21888768 dexamethasone multiple interactions ISO RGD:10812 6480464 [Dexamethasone co-treated with INS protein] results in increased expression of GRSF1 mRNA; more ... CTD PMID:11916924 dexamethasone multiple interactions ISO RGD:10812 6480464 bisphenol A inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; more ... CTD PMID:22197818 dexamethasone multiple interactions EXP   6480464 INS protein inhibits the reaction [Dexamethasone results in increased expression of G6PC mRNA]; more ... CTD PMID:18972406 dexamethasone multiple interactions EXP   6480464 [INS co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the expression of POU5F1 mRNA; more ... CTD PMID:21350315 dexamethasone increases secretion ISO RGD:731056 6480464 Dexamethasone results in increased secretion of INS protein CTD PMID:8436259 dexamethasone multiple interactions ISO RGD:731056 6480464 [Indomethacin co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPARG mRNA; more ... CTD PMID:20206132 dexamethasone decreases response to substance ISO RGD:731056 6480464 Dexamethasone results in decreased susceptibility to INS protein CTD PMID:8436259 dexamethasone multiple interactions ISO RGD:731056 6480464 Dexamethasone inhibits the reaction [INS protein results in increased uptake of Glucose] CTD PMID:18328801 diazoxide multiple interactions EXP   6480464 INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]; more ... CTD PMID:19167487 diazoxide increases expression EXP   6480464 Isoproterenol results in increased expression of INS protein CTD PMID:1129332 diazoxide affects expression EXP   6480464 Isoproterenol affects the expression of INS protein CTD PMID:1170870 digoxin decreases response to substance ISO RGD:731056 6480464 INS protein results in decreased susceptibility to Digoxin CTD PMID:22562035 digoxin decreases response to substance EXP   6480464 INS protein results in decreased susceptibility to Digoxin CTD PMID:22562035 dimercaprol multiple interactions EXP   6480464 Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]] CTD PMID:8048502 disodium selenite multiple interactions ISO RGD:731056 6480464 INS protein inhibits the reaction [Sodium Selenite results in increased secretion of SEPP1 protein] CTD PMID:18972406 disodium selenite decreases expression ISO RGD:10812 6480464 Sodium Selenite results in decreased expression of INS2 mRNA CTD PMID:23274088 dopamine multiple interactions ISO RGD:731056 6480464 Dopamine promotes the reaction [Metoclopramide results in increased expression of INS protein] CTD PMID:18645345 dopamine increases secretion ISO RGD:731056 6480464 Dopamine results in increased secretion of INS protein CTD PMID:18645345 dopamine increases expression ISO RGD:731056 6480464 Dopamine results in increased expression of INS protein CTD PMID:18645345 enalaprilat dihydrate multiple interactions ISO RGD:731056 6480464 Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein] CTD PMID:16452552 fructose decreases response to substance ISO RGD:731056 6480464 Fructose results in decreased susceptibility to INS protein CTD PMID:12010179 fructose multiple interactions EXP   6480464 INS protein inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA] CTD PMID:18360027 fulvestrant multiple interactions ISO RGD:10812 6480464 fulvestrant inhibits the reaction [bisphenol A results in increased expression of INS2 protein]; more ... CTD PMID:18446233 gatifloxacin decreases expression EXP   6480464 gatifloxacin results in decreased expression of INS2 mRNA CTD PMID:23200776 gatifloxacin multiple interactions EXP   6480464 GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA] CTD PMID:23200776 glimepiride decreases expression ISO RGD:731056 6480464 glimepiride results in decreased expression of INS protein CTD PMID:15642492 glucose multiple interactions ISO RGD:10812 6480464 Estradiol promotes the reaction [Glucose results in increased secretion of INS2 protein] CTD PMID:18446233 glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:18266981 glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... glucose multiple interactions ISO RGD:731056 6480464 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]] CTD PMID:21163946 glucose multiple interactions ISO RGD:731056 6480464 UCP3 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:18167556 glucose multiple interactions EXP   6480464 IKBKB affects the reaction [IL1B protein inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]]; more ... CTD PMID:22558381 glucose increases expression EXP   6480464 Glucose results in increased expression of INS2 mRNA alternative form CTD PMID:22558381 glucose multiple interactions ISO RGD:10812 6480464 IL1B protein inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]; more ... CTD PMID:22558381 glucose increases expression ISO RGD:10812 6480464 Glucose results in increased expression of INS2 mRNA alternative form CTD PMID:22558381 glucose multiple interactions ISO RGD:731056 6480464 MIR133A affects the reaction [Glucose results in decreased chemical synthesis of INS protein] CTD PMID:20520763 glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... glucose decreases chemical synthesis ISO RGD:731056 6480464 Glucose results in decreased chemical synthesis of INS protein CTD PMID:20520763 glucose multiple interactions ISO RGD:731056 6480464 INS protein inhibits the reaction [Glucose results in decreased expression of ATP1A1 protein] CTD PMID:22162761 glucose multiple interactions ISO RGD:731056 6480464 GW8510 promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:22242153 glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:838844 more ... glucose multiple interactions ISO RGD:731056 6480464 Metformin promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:15531508 glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Glucose CTD PMID:18328801 more ... glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Glucose CTD PMID:19531641 more ... glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:19188863 more ... glucose multiple interactions EXP   6480464 Acetylcysteine inhibits the reaction [Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS protein]] CTD PMID:21888768 glucose decreases secretion ISO RGD:731056 6480464 Glucose results in decreased secretion of INS protein CTD PMID:15642492 PMID:16452552 glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Glucose CTD PMID:15277403 more ... glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:18347054 more ... glucose multiple interactions ISO RGD:731056 6480464 TNF protein inhibits the reaction [INS protein results in increased uptake of Glucose]; more ... CTD PMID:7956951 glucose multiple interactions ISO RGD:731056 6480464 rosiglitazone promotes the reaction [INS protein results in increased uptake of Glucose] CTD PMID:15277403 glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Glucose CTD PMID:19531641 more ... glucose increases secretion ISO RGD:731056 6480464 INS protein results in increased secretion of Glucose CTD PMID:14625208 glucose multiple interactions ISO RGD:731056 6480464 IAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:16204373 glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:15153144 more ... glucose increases activity ISO RGD:731056 6480464 Glucose results in increased activity of INS promoter CTD PMID:16489446 glucose decreases secretion ISO RGD:731056 6480464 Glucose results in decreased secretion of INS protein CTD PMID:16452552 PMID:15642492 glucose multiple interactions ISO RGD:731056 6480464 Glucose inhibits the reaction [INS protein results in increased chemical synthesis of Glycogen] CTD PMID:15864539 glucose multiple interactions ISO RGD:731056 6480464 Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein] CTD PMID:16452552 glucose multiple interactions ISO RGD:731056 6480464 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]]; more ... CTD PMID:14625208 glucose decreases expression EXP   6480464 Glucose results in decreased expression of INS2 mRNA CTD PMID:12914525 glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Glucose CTD PMID:19531641 PMID:18328801 glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:838844 more ... glucose increases expression EXP   6480464 Glucose results in increased expression of INS mRNA CTD PMID:9142872 glucose increases secretion ISO RGD:10812 6480464 Glucose results in increased secretion of INS protein CTD PMID:10967106 glucose multiple interactions ISO RGD:10812 6480464 [IL1B protein co-treated with IFNG protein] promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:10967106 glucose multiple interactions ISO RGD:731056 6480464 SLC30A8 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:16984975 glucose multiple interactions ISO RGD:731056 6480464 Saquinavir inhibits the reaction [INS protein results in increased import of Glucose] CTD PMID:11786383 glucose multiple interactions ISO RGD:731056 6480464 NKX6-1 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:18347054 glucose multiple interactions ISO RGD:731056 6480464 IRS1 protein polymorphism inhibits the reaction [Glucose results in increased secretion of INS protein] CTD PMID:10430617 glucose increases uptake ISO RGD:731056 6480464 INS protein results in increased uptake of Glucose CTD PMID:18328801 glucose multiple interactions ISO RGD:731056 6480464 INS protein mutant form results in decreased uptake of and results in decreased oxidation of Glucose CTD PMID:3511099 glucose decreases secretion ISO RGD:731056 6480464 Glucose results in decreased secretion of INS protein CTD PMID:15642492 glucose increases secretion ISO RGD:731056 6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... glucose multiple interactions ISO RGD:731056 6480464 [Glyburide co-treated with Glucose] results in increased expression of INS protein CTD PMID:11305519 glucose multiple interactions ISO RGD:731056 6480464 [Glucose co-treated with sodium arsenite] results in increased secretion of INS protein; more ... CTD PMID:20100676 glucose multiple interactions ISO RGD:731056 6480464 Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]; more ... CTD PMID:20960276 glucose multiple interactions ISO RGD:731056 6480464 [Glucose co-treated with INS protein] affects the localization of PDX1 protein; more ... CTD PMID:11574405 glucose multiple interactions ISO RGD:731056 6480464 Dexamethasone inhibits the reaction [INS protein results in increased uptake of Glucose] CTD PMID:18328801 glucose multiple interactions ISO RGD:731056 6480464 Chlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein]; more ... CTD PMID:15642492 glucose multiple interactions ISO RGD:731056 6480464 alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol promotes the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:17192482 glucose multiple interactions ISO RGD:731056 6480464 3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose results in increased expression of INS mRNA]; more ... CTD PMID:16505238 glucose increases secretion ISO RGD:10812 6480464 Glucose results in increased secretion of INS2 protein CTD PMID:18446233 glyburide multiple interactions ISO RGD:731056 6480464 [Glyburide co-treated with Glucose] results in increased expression of INS protein CTD PMID:11305519 glyburide increases response to substance EXP   6480464 Glyburide results in increased susceptibility to INS protein CTD PMID:3116364 glyburide multiple interactions ISO RGD:731056 6480464 IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein] CTD PMID:10430617 glyburide increases secretion ISO RGD:731056 6480464 Glyburide results in increased secretion of INS protein CTD PMID:10430617 glyburide increases expression ISO RGD:731056 6480464 Glyburide results in increased expression of INS mRNA CTD PMID:15642492 glyburide decreases expression ISO RGD:731056 6480464 Glyburide results in decreased expression of INS protein CTD PMID:15642492 glyburide multiple interactions ISO RGD:731056 6480464 Glyburide inhibits the reaction [Glucose results in decreased secretion of INS protein] CTD PMID:15642492 glycogen multiple interactions ISO RGD:731056 6480464 Estradiol promotes the reaction [INS protein results in increased chemical synthesis of Glycogen]; more ... CTD PMID:21632903 glycogen increases chemical synthesis ISO RGD:731056 6480464 INS protein results in increased chemical synthesis of Glycogen CTD PMID:21632903 PMID:15864539 glycogen increases chemical synthesis ISO RGD:731056 6480464 INS protein results in increased chemical synthesis of Glycogen CTD PMID:15864539 PMID:21632903 glycogen multiple interactions ISO RGD:731056 6480464 Glucose inhibits the reaction [INS protein results in increased chemical synthesis of Glycogen] CTD PMID:15864539 glycogen increases chemical synthesis ISO RGD:731056 6480464 INS protein results in increased chemical synthesis of Glycogen CTD PMID:21632903 hydrogen peroxide increases chemical synthesis ISO RGD:731056 6480464 INS protein results in increased chemical synthesis of Hydrogen Peroxide CTD PMID:22031853 hydrogen peroxide multiple interactions ISO RGD:731056 6480464 manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [INS protein results in increased chemical synthesis of Hydrogen Peroxide] CTD PMID:22031853 indomethacin multiple interactions ISO RGD:731056 6480464 [Indomethacin co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPARG protein; more ... CTD PMID:20206132 indomethacin multiple interactions ISO RGD:731056 6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of CIDEC mRNA; more ... CTD PMID:23086663 indomethacin decreases secretion ISO RGD:731056 6480464 Indomethacin results in decreased secretion of INS protein CTD PMID:10909992 isoprenaline multiple interactions EXP   6480464 INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]; more ... CTD PMID:19167487 isoprenaline increases expression EXP   6480464 Isoproterenol results in increased expression of INS protein CTD PMID:1129332 isoprenaline affects expression EXP   6480464 Isoproterenol affects the expression of INS protein CTD PMID:1170870 lanthanum atom decreases response to substance ISO RGD:731056 6480464 Lanthanum results in decreased susceptibility to INS protein CTD PMID:22031853 lipoic acid multiple interactions ISO RGD:731056 6480464 Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 lovastatin multiple interactions EXP   6480464 Lovastatin promotes the reaction [INS protein results in increased phosphorylation of IGF1R protein]; more ... CTD PMID:19741129 LY294002 multiple interactions ISO RGD:731056 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:17550345 LY294002 multiple interactions ISO RGD:731056 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:17550345 PMID:18359480 LY294002 multiple interactions ISO RGD:731056 6480464 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:18359480 mercaptopurine decreases expression EXP   6480464 6-Mercaptopurine results in decreased expression of INS2 mRNA CTD PMID:23358152 metformin multiple interactions ISO RGD:731056 6480464 Metformin results in decreased expression of and results in decreased secretion of INS protein CTD PMID:18082302 metformin multiple interactions ISO RGD:731056 6480464 Metformin promotes the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:15531508 metformin increases expression ISO RGD:731056 6480464 Metformin results in increased expression of INS mRNA CTD PMID:15531508 metformin decreases expression ISO RGD:731056 6480464 Metformin results in decreased expression of INS protein CTD PMID:21779873 PMID:1900072 metformin decreases expression ISO RGD:731056 6480464 Metformin results in decreased expression of INS protein CTD PMID:1900072 PMID:21779873 metformin decreases expression ISO RGD:731056 6480464 Metformin results in decreased expression of INS protein CTD PMID:1900072 methadone decreases response to substance ISO RGD:731056 6480464 Methadone results in decreased susceptibility to INS protein CTD PMID:2554359 methotrexate decreases expression ISO RGD:731056 6480464 Methotrexate results in decreased expression of INS mRNA CTD PMID:17400583 metoclopramide multiple interactions ISO RGD:731056 6480464 Dopamine promotes the reaction [Metoclopramide results in increased expression of INS protein] CTD PMID:18645345 metoclopramide increases expression ISO RGD:731056 6480464 Metoclopramide results in increased expression of INS protein CTD PMID:18645345 N-acetyl-L-cysteine multiple interactions ISO RGD:731056 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 N-acetyl-L-cysteine multiple interactions EXP   6480464 Acetylcysteine inhibits the reaction [Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS protein]] CTD PMID:21888768 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:10812 6480464 Ethylnitrosourea results in increased mutagenesis of INS2 gene CTD PMID:18056790 nicotinamide multiple interactions ISO RGD:731056 6480464 Niacinamide inhibits the reaction [Glucose results in increased expression of INS mRNA]; more ... CTD PMID:16505238 nitric oxide multiple interactions ISO RGD:731056 6480464 resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]; more ... CTD PMID:20960276 nitric oxide increases secretion ISO RGD:731056 6480464 INS protein results in increased secretion of Nitric Oxide CTD PMID:20960276 olanzapine increases expression ISO RGD:731056 6480464 olanzapine results in increased expression of INS protein CTD PMID:16601995 more ... olanzapine increases expression ISO RGD:731056 6480464 olanzapine results in increased expression of INS protein CTD PMID:11927762 more ... olanzapine increases expression ISO RGD:731056 6480464 olanzapine results in increased expression of INS protein CTD PMID:16601995 more ... olanzapine increases expression ISO RGD:731056 6480464 olanzapine results in increased expression of INS protein CTD PMID:19512971 more ... olanzapine increases secretion ISO RGD:731056 6480464 olanzapine results in increased secretion of INS protein CTD PMID:11769361 oleic acid multiple interactions ISO RGD:731056 6480464 Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]; more ... CTD PMID:11292061 palmitic acid multiple interactions ISO RGD:731056 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of INS protein]] CTD PMID:18155663 palmitic acid multiple interactions ISO RGD:10812 6480464 Palmitic Acid inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form] CTD PMID:22558381 palmitic acid decreases expression ISO RGD:731056 6480464 Palmitic Acid results in decreased expression of INS protein CTD PMID:18155663 paroxetine multiple interactions EXP   6480464 anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]] CTD PMID:17728140 pentolinium tartrate multiple interactions ISO RGD:731056 6480464 Pentolinium Tartrate inhibits the reaction [Epinephrine results in decreased secretion of INS protein] CTD PMID:1218171 phenobarbital multiple interactions EXP   6480464 INS protein affects the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]; more ... CTD PMID:10215695 potassium chloride multiple interactions ISO RGD:731056 6480464 sodium arsenite promotes the reaction [Potassium Chloride results in increased secretion of INS protein] CTD PMID:20100676 propranolol multiple interactions ISO RGD:731056 6480464 Propranolol inhibits the reaction [Epinephrine results in decreased expression of INS protein] CTD PMID:6018752 propranolol decreases expression ISO RGD:731056 6480464 Propranolol results in decreased expression of INS protein CTD PMID:3019152 purine-6-thiol decreases expression EXP   6480464 6-Mercaptopurine results in decreased expression of INS2 mRNA CTD PMID:23358152 pyridine multiple interactions EXP   6480464 INS protein affects the reaction [pyridine results in increased expression of CYP2B1 mRNA]; more ... CTD PMID:10215695 pyruvic acid multiple interactions EXP   6480464 INS protein inhibits the reaction [Pyruvic Acid results in increased secretion of GCG protein] CTD PMID:15919803 quercetin multiple interactions ISO RGD:731056 6480464 Quercetin inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 quercetin multiple interactions ISO RGD:731056 6480464 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; more ... CTD PMID:18359480 resveratrol increases response to substance ISO RGD:10812 6480464 resveratrol results in increased susceptibility to INS protein CTD PMID:21945106 resveratrol multiple interactions ISO RGD:731056 6480464 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]] CTD PMID:21163946 resveratrol multiple interactions ISO RGD:731056 6480464 resveratrol inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:17550345 PMID:16626303 resveratrol multiple interactions ISO RGD:731056 6480464 resveratrol inhibits the reaction [INS protein results in increased phosphorylation of FOXO4 protein] CTD PMID:17550345 resveratrol multiple interactions ISO RGD:731056 6480464 resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]; more ... CTD PMID:20960276 resveratrol decreases response to substance ISO RGD:731056 6480464 INS protein results in decreased susceptibility to resveratrol CTD PMID:20015842 resveratrol multiple interactions ISO RGD:731056 6480464 resveratrol inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:16626303 PMID:17550345 resveratrol decreases expression ISO RGD:10812 6480464 resveratrol results in decreased expression of INS protein CTD PMID:21945106 resveratrol decreases response to substance ISO RGD:731056 6480464 resveratrol results in decreased susceptibility to INS protein CTD PMID:15297429 resveratrol multiple interactions ISO RGD:731056 6480464 resveratrol inhibits the reaction [INS protein results in increased expression of HIF1A protein] CTD PMID:15297429 risperidone increases expression ISO RGD:731056 6480464 Risperidone results in increased expression of INS protein CTD PMID:11927762 PMID:16601995 risperidone increases expression ISO RGD:731056 6480464 Risperidone results in increased expression of INS protein CTD PMID:16601995 PMID:11927762 rosiglitazone multiple interactions ISO RGD:731056 6480464 [rosiglitazone co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA; more ... CTD PMID:20206132 rosiglitazone multiple interactions ISO RGD:731056 6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of ADIPOQ mRNA; more ... CTD PMID:23086663 rosiglitazone increases response to substance ISO RGD:731056 6480464 rosiglitazone results in increased susceptibility to INS protein CTD PMID:15730735 more ... rosiglitazone decreases expression ISO RGD:731056 6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:15089784 more ... rosiglitazone decreases expression ISO RGD:731056 6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:20498286 more ... rosiglitazone decreases expression ISO RGD:731056 6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:19556978 more ... rosiglitazone increases response to substance ISO RGD:731056 6480464 rosiglitazone results in increased susceptibility to INS protein CTD PMID:15730735 more ... rosiglitazone increases response to substance ISO RGD:731056 6480464 rosiglitazone results in increased susceptibility to INS protein CTD PMID:16644639 more ... rosiglitazone decreases expression ISO RGD:731056 6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:20498286 more ... rosiglitazone multiple interactions ISO RGD:10812 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with INS protein] results in increased expression of FOSL1 mRNA; more ... CTD PMID:11916924 rosiglitazone increases expression ISO RGD:731056 6480464 rosiglitazone results in increased expression of INS mRNA CTD PMID:18155663 rosiglitazone decreases expression ISO RGD:731056 6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:15089784 more ... rosiglitazone multiple interactions ISO RGD:731056 6480464 rosiglitazone promotes the reaction [INS protein results in increased uptake of Glucose] CTD PMID:15277403 rosiglitazone multiple interactions ISO RGD:731056 6480464 rosiglitazone inhibits the reaction [INS protein results in increased secretion of RETN protein] CTD PMID:14671216 rosiglitazone multiple interactions ISO RGD:731056 6480464 rosiglitazone inhibits the reaction [IAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]] CTD PMID:16204373 rosiglitazone multiple interactions ISO RGD:731056 6480464 rosiglitazone inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of INS mRNA]; more ... CTD PMID:14625208 rosiglitazone multiple interactions ISO RGD:731056 6480464 rosiglitazone inhibits the reaction and results in increased secretion of INS protein inhibits the reaction and results in increased secretion of SERPINE1 protein CTD PMID:12940867 rosiglitazone multiple interactions ISO RGD:731056 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of INS protein]] CTD PMID:18155663 rosiglitazone increases response to substance ISO RGD:731056 6480464 rosiglitazone results in increased susceptibility to INS protein CTD PMID:19531641 more ... rosiglitazone decreases expression ISO RGD:731056 6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:15730735 more ... rosiglitazone multiple interactions ISO RGD:731056 6480464 rosiglitazone inhibits the reaction [INS protein results in increased expression of NAMPT protein] CTD PMID:21694775 rosiglitazone increases response to substance ISO RGD:731056 6480464 rosiglitazone results in increased susceptibility to INS protein CTD PMID:15730735 PMID:16644639 rosiglitazone decreases secretion ISO RGD:731056 6480464 rosiglitazone results in decreased secretion of INS protein CTD PMID:18541328 rosiglitazone decreases expression ISO RGD:731056 6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:15730735 more ... saquinavir multiple interactions ISO RGD:731056 6480464 Saquinavir inhibits the reaction [INS protein results in increased import of Glucose] CTD PMID:11786383 sertraline multiple interactions EXP   6480464 Sertraline affects the reaction [INS protein affects the phosphorylation of IRS1 protein]; more ... CTD PMID:17728140 sodium dichromate increases expression ISO RGD:10812 6480464 sodium bichromate results in increased expression of INS2 mRNA CTD PMID:22155349 staurosporine multiple interactions EXP   6480464 Staurosporine inhibits the reaction [INS protein results in increased uptake of cobaltous chloride] CTD PMID:14622148 streptozocin multiple interactions ISO RGD:731056 6480464 INS inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]; more ... CTD PMID:19136650 streptozocin decreases expression EXP   6480464 Streptozocin results in decreased expression of INS protein CTD PMID:11216864 streptozocin multiple interactions EXP   6480464 INS protein inhibits the reaction [Streptozocin results in decreased expression of FASN mRNA]; more ... CTD PMID:20219977 streptozocin multiple interactions ISO RGD:731056 6480464 INS protein inhibits the reaction [Streptozocin results in decreased expression of NES mRNA] CTD PMID:19388005 sucrose increases expression ISO RGD:731056 6480464 Sucrose results in increased expression of INS protein CTD PMID:1805284 sulpiride increases expression ISO RGD:731056 6480464 Sulpiride results in increased expression of INS protein CTD PMID:16601995 tacrolimus hydrate decreases expression ISO RGD:731056 6480464 Tacrolimus results in decreased expression of INS protein CTD PMID:17391142 telmisartan decreases expression ISO RGD:731056 6480464 telmisartan results in decreased expression of INS protein CTD PMID:15892894 terbutaline multiple interactions ISO RGD:731056 6480464 Atenolol inhibits the reaction [Terbutaline results in increased expression of INS protein]; more ... CTD PMID:12795776 terbutaline multiple interactions ISO RGD:731056 6480464 SST inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:2563217 terbutaline increases expression ISO RGD:731056 6480464 Terbutaline results in increased expression of INS protein CTD PMID:12795776 more ... testosterone multiple interactions ISO RGD:731056 6480464 Testosterone promotes the reaction [INS protein results in increased chemical synthesis of Glycogen]; more ... CTD PMID:21632903 testosterone increases expression ISO RGD:731056 6480464 Testosterone results in increased expression of INS protein CTD PMID:9851674 tolbutamide increases secretion ISO RGD:731056 6480464 Tolbutamide results in increased secretion of INS protein CTD PMID:9568693 PMID:9032110 tolbutamide increases secretion ISO RGD:731056 6480464 Tolbutamide results in increased secretion of INS protein CTD PMID:9032110 PMID:9568693 tolbutamide multiple interactions ISO RGD:731056 6480464 ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein] CTD PMID:9568693 trans-resveratrol increases response to substance ISO RGD:10812 6480464 resveratrol results in increased susceptibility to INS protein CTD PMID:21945106 trans-resveratrol multiple interactions ISO RGD:731056 6480464 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]] CTD PMID:21163946 trans-resveratrol multiple interactions ISO RGD:731056 6480464 resveratrol inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:17550345 PMID:16626303 trans-resveratrol multiple interactions ISO RGD:731056 6480464 resveratrol inhibits the reaction [INS protein results in increased phosphorylation of FOXO4 protein] CTD PMID:17550345 trans-resveratrol multiple interactions ISO RGD:731056 6480464 resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]; more ... CTD PMID:20960276 trans-resveratrol decreases response to substance ISO RGD:731056 6480464 INS protein results in decreased susceptibility to resveratrol CTD PMID:20015842 trans-resveratrol multiple interactions ISO RGD:731056 6480464 resveratrol inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:16626303 PMID:17550345 trans-resveratrol decreases expression ISO RGD:10812 6480464 resveratrol results in decreased expression of INS protein CTD PMID:21945106 trans-resveratrol decreases response to substance ISO RGD:731056 6480464 resveratrol results in decreased susceptibility to INS protein CTD PMID:15297429 trans-resveratrol multiple interactions ISO RGD:731056 6480464 resveratrol inhibits the reaction [INS protein results in increased expression of HIF1A protein] CTD PMID:15297429 tributylstannane multiple interactions ISO RGD:10812 6480464 tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; more ... CTD PMID:22197818 troglitazone decreases expression ISO RGD:731056 6480464 troglitazone results in decreased expression of INS protein CTD PMID:10406828 troglitazone decreases expression ISO RGD:731056 6480464 troglitazone results in decreased expression of INS protein CTD PMID:10406828 more ... troglitazone decreases expression ISO RGD:731056 6480464 troglitazone results in decreased expression of INS protein CTD PMID:21779873 more ... troglitazone decreases expression ISO RGD:731056 6480464 troglitazone results in decreased expression of INS protein CTD PMID:8772734 more ... troglitazone multiple interactions ISO RGD:731056 6480464 troglitazone promotes the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]; more ... CTD PMID:11292061 troglitazone increases response to substance ISO RGD:731056 6480464 troglitazone results in increased susceptibility to INS protein CTD PMID:8772734 troglitazone decreases expression ISO RGD:731056 6480464 troglitazone results in decreased expression of INS protein CTD PMID:21779873 more ... troglitazone multiple interactions ISO RGD:731056 6480464 troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased expression of CEBPA mRNA]]; more ... CTD PMID:7956951 troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of INS2 mRNA CTD PMID:12914525 troglitazone decreases expression ISO RGD:731056 6480464 troglitazone results in decreased expression of INS protein CTD PMID:21779873 PMID:10406828 troglitazone multiple interactions ISO RGD:731056 6480464 troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]] CTD PMID:16483873 wortmannin multiple interactions ISO RGD:731056 6480464 [wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein] CTD PMID:11574405 wortmannin multiple interactions ISO RGD:731056 6480464 wortmannin inhibits the reaction [INS protein results in decreased susceptibility to Coumaric Acids] CTD PMID:20015842 wortmannin multiple interactions EXP   6480464 wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:17728140 wortmannin multiple interactions ISO RGD:731056 6480464 wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:17550345 yohimbine increases expression ISO RGD:731056 6480464 Yohimbine results in increased expression of INS protein CTD PMID:1972139 zinc atom affects binding ISO RGD:731056 6480464 Zinc binds to INS protein CTD PMID:16969698 zinc atom affects binding ISO RGD:731056 6480464 Zinc binds to INS protein binds to INS protein CTD PMID:16362452 zinc(0) affects binding ISO RGD:731056 6480464 Zinc binds to INS protein CTD PMID:16969698 zinc(0) affects binding ISO RGD:731056 6480464 Zinc binds to INS protein binds to INS protein CTD PMID:16362452 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) activation of JUN kinase activity NOT ISO RGD:10812 1624291 MGI:MGI:2387283|PMID:12059784 RGD MGI:MGI:2387283 PMID:12059784 activation of MAPK activity   ISO RGD:10812 1624291 MGI:MGI:2387283|PMID:12059784 RGD MGI:MGI:2387283 PMID:12059784 activation of MAPK activity   IEA Ensembl:ENSMUSP00000101553 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 activation of protein kinase B activity   ISO RGD:731056 1624291 PMID:8702995 RGD PMID:8702995 acute-phase response   ISO RGD:731056 1624291 PMID:14739855 RGD PMID:14739855 alpha-beta T cell activation   ISO RGD:731056 1624291 PMID:10604997 RGD PMID:10604997 biological_process   ND   1598407 06/2009: no relevant rat data RGD   canonical Wnt receptor signaling pathway   ISO RGD:10812 1624291 MGI:MGI:1861437 RGD MGI:MGI:3522557 PMID:15282335 canonical Wnt receptor signaling pathway   IEA Ensembl:ENSMUSP00000101553 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 ER overload response   ISO RGD:10812 1624291 MGI:MGI:1857572 RGD MGI:MGI:2158984 PMID:11854325 ER overload response   IEA Ensembl:ENSMUSP00000101553 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 fatty acid homeostasis   ISO RGD:731056 1624291 PMID:1184755 RGD PMID:1184755 G-protein coupled receptor signaling pathway   ISO RGD:731056 1624291 PMID:9092559 RGD PMID:9092559 glucose homeostasis   ISO RGD:731056 1624291 PMID:381941 RGD PMID:381941 glucose metabolic process   ISO RGD:10812 1624291 MGI:MGI:1857572 RGD MGI:MGI:2158984 PMID:11854325 glucose metabolic process   IEA Ensembl:ENSMUSP00000101553 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 glucose transport   ISO RGD:731056 1624291 PMID:14615391 RGD PMID:14615391 glucose transport   ISO RGD:731056 1624291 PMID:15792832 RGD PMID:15792832 insulin receptor signaling pathway   ISO RGD:10812 1624291 MGI:MGI:2664440|PMID:12805218 RGD MGI:MGI:2664440 PMID:12805218 insulin receptor signaling pathway   IEA Ensembl:ENSMUSP00000101553 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 lipid catabolic process   ISO RGD:10812 1624291 MGI:MGI:2664440|PMID:12805218 RGD MGI:MGI:2664440 PMID:12805218 lipid catabolic process   IEA Ensembl:ENSMUSP00000101553 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 MAPK cascade   ISO RGD:731056 1624291 PMID:11278339 RGD PMID:11278339 myoblast fusion   ISO RGD:10812 1624291 MGI:MGI:1861437 RGD MGI:MGI:3522557 PMID:15282335 myoblast fusion   IEA Ensembl:ENSMUSP00000101553 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 myotube differentiation   ISO RGD:10812 1624291 MGI:MGI:1861437 RGD MGI:MGI:3522557 PMID:15282335 negative regulation of acute inflammatory response   ISO RGD:731056 1624291 PMID:11443198 RGD PMID:11443198 negative regulation of fatty acid metabolic process   ISO RGD:731056 1624291 PMID:1184755 RGD PMID:1184755 negative regulation of feeding behavior   ISO RGD:731056 1624291 PMID:17957153 RGD PMID:17957153 negative regulation of glycogen catabolic process   ISO RGD:731056 1624291 PMID:381941 RGD PMID:381941 negative regulation of NAD(P)H oxidase activity   ISO RGD:731056 1624291 PMID:11443198 RGD PMID:11443198 negative regulation of protein catabolic process   ISO RGD:731056 1624291 PMID:15185208 RGD PMID:15185208 negative regulation of protein oligomerization   ISO RGD:731056 1624291 PMID:9830016 RGD PMID:9830016 negative regulation of protein secretion   ISO RGD:731056 1624291 PMID:14739855 RGD PMID:14739855 negative regulation of proteolysis   ISO RGD:731056 1624291 PMID:3553851 RGD PMID:3553851 negative regulation of respiratory burst involved in inflammatory response   ISO RGD:731056 1624291 PMID:11443198 RGD PMID:11443198 negative regulation of transcription from RNA polymerase II promoter   ISO RGD:10812 1624291 MGI:MGI:1276655|PMID:9689059 RGD MGI:MGI:1276655 PMID:9689059 negative regulation of transcription from RNA polymerase II promoter   IEA Ensembl:ENSMUSP00000101553 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of cell proliferation   ISO RGD:731056 1624291 PMID:17925406 RGD PMID:17925406 positive regulation of cellular protein metabolic process   ISO RGD:731056 1624291 PMID:3553851 RGD PMID:3553851 positive regulation of cytokine secretion   ISO RGD:731056 1624291 PMID:15473891 RGD PMID:15473891 positive regulation of DNA replication   ISO RGD:731056 1624291 PMID:7688386 RGD PMID:7688386 positive regulation of glucose import   ISO RGD:731056 1624291 PMID:14615391 RGD PMID:14615391 positive regulation of glycogen biosynthetic process   ISO RGD:731056 1624291 PMID:17925406 RGD PMID:17925406 positive regulation of glycolysis   ISO RGD:731056 1624291 PMID:381941 RGD PMID:381941 positive regulation of glycolysis   ISO RGD:731056 1624291 PMID:7688386 RGD PMID:7688386 positive regulation of insulin receptor signaling pathway   ISO RGD:731056 1624291 PMID:7688386 RGD PMID:7688386 positive regulation of MAPK cascade   ISO RGD:731056 1624291 PMID:11500939 RGD PMID:11500939 positive regulation of mitosis   ISO RGD:731056 1624291 PMID:10644978 RGD PMID:10644978 positive regulation of mitosis   ISO RGD:731056 1624291 PMID:11500939 RGD PMID:11500939 positive regulation of NF-kappaB transcription factor activity   ISO RGD:731056 1624291 PMID:19727662 RGD PMID:19727662 positive regulation of peptidyl-tyrosine phosphorylation   ISO RGD:731056 1624291 PMID:11278339 RGD PMID:11278339 positive regulation of phosphatidylinositol 3-kinase activity   ISO RGD:10812 1624291 MGI:MGI:3620320|PMID:11375348 RGD MGI:MGI:3620320 PMID:11375348 positive regulation of phosphatidylinositol 3-kinase activity   IEA Ensembl:ENSMUSP00000101553 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of phosphatidylinositol 3-kinase cascade   ISO RGD:731056 1624291 PMID:7688386 RGD PMID:7688386 positive regulation of protein kinase B signaling cascade   ISO RGD:731056 1624291 PMID:11500939 RGD PMID:11500939 positive regulation of respiratory burst   ISO RGD:731056 1624291 PMID:9092559 RGD PMID:9092559 regulation of apoptotic process   ISO RGD:10812 1624291 MGI:MGI:1857572 RGD MGI:MGI:2158984 PMID:11854325 regulation of apoptotic process   IEA Ensembl:ENSMUSP00000101553 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of cellular amino acid metabolic process   ISO RGD:731056 1624291 PMID:3553851 RGD PMID:3553851 regulation of gene expression   ISO RGD:10812 1624291 MGI:MGI:3848759|PMID:19293336 RGD MGI:MGI:3848759 PMID:19293336 regulation of phosphorylation   ISO RGD:10812 1624291 MGI:MGI:2387283|PMID:12059784 RGD MGI:MGI:2387283 PMID:12059784 regulation of protein binding   ISO RGD:10812 1624291 MGI:MGI:1201285|PMID:9507006 RGD MGI:MGI:1201285 PMID:9507006 regulation of protein binding   IEA Ensembl:ENSMUSP00000101553 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of protein localization   ISO RGD:731056 1624291 PMID:14615391 RGD PMID:14615391 regulation of protein secretion   ISO RGD:731056 1624291 PMID:15591776 RGD PMID:15591776 regulation of transmembrane transporter activity   ISO RGD:731056 1624291 PMID:14615391 RGD PMID:14615391 wound healing   ISO RGD:731056 1624291 PMID:9498508 RGD PMID:9498508 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytoplasm   ISO RGD:10812 1624291 MGI:MGI:3614320|PMID:15793245 RGD MGI:MGI:3614320 PMID:15793245 extracellular space   IDA   2298715   RGD   extracellular space   ISO RGD:731056 1624291 PMID:9667398 RGD PMID:9667398 nucleus   ISO RGD:10812 1624291 MGI:MGI:2447254|PMID:12488434 RGD MGI:MGI:2447254 PMID:12488434 nucleus   IEA Ensembl:ENSMUSP00000101553 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 secretory granule Colocalizes_with IDA RGD:3273 RGD:3272 2308908 proinsulin, pancreatic islet beta-cells RGD   secretory granule   ISO RGD:10812 1624291 MGI:MGI:3589494|PMID:15788565 RGD MGI:MGI:3589494 PMID:15788565 secretory granule Colocalizes_with IDA RGD:621314 RGD:3272 1625123 proinsulin, pancreatic tissue RGD   secretory granule   IDA   1625123   RGD   small nucleolar ribonucleoprotein complex   ISO RGD:10812 1624291 MGI:MGI:2447254|PMID:12488434 RGD MGI:MGI:2447254 PMID:12488434 small nucleolar ribonucleoprotein complex   IEA Ensembl:ENSMUSP00000101553 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) hormone activity   ISO RGD:731056 1624291 PMID:381941 RGD PMID:381941 hormone activity   IEA UniProtKB-KW:KW-0372 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 insulin receptor binding   ISO RGD:731056 1624291 PMID:7556975 RGD PMID:7556975 insulin receptor binding   ISO RGD:731056 1624291 PMID:9667398 RGD PMID:9667398 insulin receptor binding   ISO RGD:731056 1624291 UniProtKB:P06213 RGD PMID:8452530 insulin-like growth factor receptor binding   ISO RGD:731056 1624291 UniProtKB:P08069 RGD PMID:8452530 protease binding   IPI RGD:3272 1625123   RGD   protease binding   ISO RGD:731056 1624291 UniProtKB:P14735 RGD PMID:20082125 protein binding   ISO RGD:731056 1624291 UniProtKB:P17936 RGD PMID:9388210 protein binding   ISO RGD:731056 1624291 UniProtKB:P98164 RGD PMID:9773776 protein complex binding   IPI RGD:621314 RGD:3272 1625123 proinsulin, total pancreatic islet cell extracts RGD   Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) aldosterone signaling pathway   IEA RGD:2916 6907045   KEGG rno:04960 altered insulin signaling pathway   ISS RGD:731056 2313694   RGD   autophagy pathway   IEA RGD:2916 6907045   KEGG rno:04140 forkhead class A signaling pathway   ISO RGD:731056 6484113   PID PID:200226 forkhead class A signaling pathway   ISO RGD:731056 6484113   PID PID:200087 insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISO RGD:731056 6484113   PID PID:200196 insulin signaling pathway   ISS RGD:731056 1625124   RGD   insulin signaling pathway   ISO RGD:731056 6484113   PID PID:200014 insulin signaling pathway   IEA RGD:2916 6907045   KEGG rno:04910 maturity onset diabetes of the young pathway   IEA RGD:2916 6907045   KEGG rno:04950 mTOR signaling pathway   IEA RGD:2916 6907045   KEGG rno:04150 prostate cancer pathway   IEA RGD:2916 6907045   KEGG rno:05215 type 1 diabetes mellitus pathway   IEA RGD:2916 6907045   KEGG rno:04940 type 2 diabetes mellitus pathway   ISS RGD:731056 2313694   RGD   type 2 diabetes mellitus pathway   IEA RGD:2916 6907045   KEGG rno:04930 External Database Links KEGG Pathway Aldosterone-regulated sodium reabsorption HIF-1 signaling pathway Insulin secretion Insulin signaling pathway Maturity onset diabetes of the young mTOR signaling pathway Oocyte meiosis PI3K-Akt signaling pathway Progesterone-mediated oocyte maturation Prostate cancer Regulation of actin cytoskeleton Regulation of autophagy Type I diabetes mellitus Type II diabetes mellitus Pathway Interaction Database Arf6 trafficking events (PID:200057) ATF-2 transcription factor network (PID:200135) FOXA1 transcription factor network (PID:200226) FOXA2 and FOXA3 transcription factor networks (PID:200087) Insulin Pathway (PID:200014) Insulin-mediated glucose transport (PID:200196) Signaling events mediated by PTP1B (PID:200042) Signaling events mediated by TCPTP (PID:200078) Disease Annotations Adenoma  (ISS) Alzheimer Disease  (IEP) Carcinoma, Pancreatic Ductal  (ISS) Diabetes Mellitus  (ISS) Diabetes Mellitus, Permanent Neonatal  (ISS) Diabetes Mellitus, Type 1  (ISS) Diabetes Mellitus, Type 2  (ISS) Diabetes, Gestational  (ISS) Diabetic Nephropathies  (IED) Diabetic Retinopathy  (ISS) Fatty Liver  (ISS) Hyperinsulinism  (ISS) Hypertension  (IED) Hyperuricemia  (ISS) Insulin Resistance  (ISS) Insulinoma  (ISS) MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 10  (ISS) Obesity  (ISS) Pancreatic Neoplasms  (ISS) Gene-Chemical Interaction Annotations (R)-adrenaline  (ISO) (R)-lipoic acid  (ISO) (S)-nicotine  (EXP) 17beta-estradiol  (EXP,ISO) 2,6-dinitrotoluene  (EXP) 2-amino-2-deoxy-D-glucopyranose  (ISO) 2-deoxy-D-glucose  (ISO) 3-aminobenzamide  (ISO) 3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO) 4-phenylbutyric acid  (ISO) 5-fluorouracil  (ISO) AACOCF3  (ISO) acetic acid  (ISO) albuterol  (ISO) aldehydo-D-glucosamine  (ISO) all-trans-retinoic acid  (ISO) all-trans-retinol  (ISO) amlodipine  (ISO) ammonium chloride  (EXP) arachidonic acid  (ISO) aspartame  (ISO) atenolol  (ISO) baicalein  (ISO) beta-D-glucosamine  (ISO) bezafibrate  (ISO) bis(2-ethylhexyl) phthalate  (ISO) bisoprolol  (ISO) bisphenol A  (EXP,ISO) bromochloroacetic acid  (ISO) bromocriptine  (ISO) cadmium atom  (ISO) caffeine  (ISO) capsaicin  (EXP) carvedilol  (ISO) chlorpropamide  (ISO) ciprofibrate  (EXP) clofibrate  (ISO) clonidine  (ISO) clonidine (amino form)  (ISO) clonidine (imino form)  (ISO) clozapine  (ISO) co-trimoxazole  (ISO) cobalt dichloride  (EXP) cocaine  (ISO) copper atom  (ISO) copper(0)  (ISO) corticotropin  (ISO) cortisol  (ISO) D-glucose  (EXP,ISO) demethoxycurcumin  (ISO) dexamethasone  (EXP,ISO) diazoxide  (EXP) digoxin  (EXP,ISO) dimercaprol  (EXP) disodium selenite  (ISO) dopamine  (ISO) enalaprilat dihydrate  (ISO) fructose  (EXP,ISO) fulvestrant  (ISO) gatifloxacin  (EXP) glimepiride  (ISO) glucose  (EXP,ISO) glyburide  (EXP,ISO) glycogen  (ISO) hydrogen peroxide  (ISO) indomethacin  (ISO) isoprenaline  (EXP) lanthanum atom  (ISO) lipoic acid  (ISO) lovastatin  (EXP) LY294002  (ISO) mercaptopurine  (EXP) metformin  (ISO) methadone  (ISO) methotrexate  (ISO) metoclopramide  (ISO) N-acetyl-L-cysteine  (EXP,ISO) N-ethyl-N-nitrosourea  (ISO) nicotinamide  (ISO) nitric oxide  (ISO) olanzapine  (ISO) oleic acid  (ISO) palmitic acid  (ISO) paroxetine  (EXP) pentolinium tartrate  (ISO) phenobarbital  (EXP) potassium chloride  (ISO) propranolol  (ISO) purine-6-thiol  (EXP) pyridine  (EXP) pyruvic acid  (EXP) quercetin  (ISO) resveratrol  (ISO) risperidone  (ISO) rosiglitazone  (ISO) saquinavir  (ISO) sertraline  (EXP) sodium dichromate  (ISO) staurosporine  (EXP) streptozocin  (EXP,ISO) sucrose  (ISO) sulpiride  (ISO) tacrolimus hydrate  (ISO) telmisartan  (ISO) terbutaline  (ISO) testosterone  (ISO) tolbutamide  (ISO) trans-resveratrol  (ISO) tributylstannane  (ISO) troglitazone  (EXP,ISO) wortmannin  (EXP,ISO) yohimbine  (ISO) zinc atom  (ISO) zinc(0)  (ISO) Gene Ontology Annotations Biological Process activation of JUN kinase activity  (ISO) activation of MAPK activity  (IEA,ISO) activation of protein kinase B activity  (ISO) acute-phase response  (ISO) alpha-beta T cell activation  (ISO) biological_process  (ND) canonical Wnt receptor signaling pathway  (IEA,ISO) ER overload response  (IEA,ISO) fatty acid homeostasis  (ISO) G-protein coupled receptor signaling pathway  (ISO) glucose homeostasis  (ISO) glucose metabolic process  (IEA,ISO) glucose transport  (ISO) insulin receptor signaling pathway  (IEA,ISO) lipid catabolic process  (IEA,ISO) MAPK cascade  (ISO) myoblast fusion  (IEA,ISO) myotube differentiation  (ISO) negative regulation of acute inflammatory response  (ISO) negative regulation of fatty acid metabolic process  (ISO) negative regulation of feeding behavior  (ISO) negative regulation of glycogen catabolic process  (ISO) negative regulation of NAD(P)H oxidase activity  (ISO) negative regulation of protein catabolic process  (ISO) negative regulation of protein oligomerization  (ISO) negative regulation of protein secretion  (ISO) negative regulation of proteolysis  (ISO) negative regulation of respiratory burst involved in inflammatory response  (ISO) negative regulation of transcription from RNA polymerase II promoter  (IEA,ISO) positive regulation of cell proliferation  (ISO) positive regulation of cellular protein metabolic process  (ISO) positive regulation of cytokine secretion  (ISO) positive regulation of DNA replication  (ISO) positive regulation of glucose import  (ISO) positive regulation of glycogen biosynthetic process  (ISO) positive regulation of glycolysis  (ISO) positive regulation of insulin receptor signaling pathway  (ISO) positive regulation of MAPK cascade  (ISO) positive regulation of mitosis  (ISO) positive regulation of NF-kappaB transcription factor activity  (ISO) positive regulation of peptidyl-tyrosine phosphorylation  (ISO) positive regulation of phosphatidylinositol 3-kinase activity  (IEA,ISO) positive regulation of phosphatidylinositol 3-kinase cascade  (ISO) positive regulation of protein kinase B signaling cascade  (ISO) positive regulation of respiratory burst  (ISO) regulation of apoptotic process  (IEA,ISO) regulation of cellular amino acid metabolic process  (ISO) regulation of gene expression  (ISO) regulation of phosphorylation  (ISO) regulation of protein binding  (IEA,ISO) regulation of protein localization  (ISO) regulation of protein secretion  (ISO) regulation of transmembrane transporter activity  (ISO) wound healing  (ISO) Cellular Component cytoplasm  (ISO) extracellular space  (IDA,ISO) nucleus  (IEA,ISO) secretory granule  (IDA,ISO) small nucleolar ribonucleoprotein complex  (IEA,ISO) Molecular Function hormone activity  (IEA,ISO) insulin receptor binding  (ISO) insulin-like growth factor receptor binding  (ISO) protease binding  (IPI,ISO) protein binding  (ISO) protein complex binding  (IPI) Molecular Pathway Annotations aldosterone signaling pathway  (IEA) altered insulin signaling pathway  (ISS) autophagy pathway  (IEA) forkhead class A signaling pathway  (ISO) insulin responsive facilitative sugar transporter mediated glucose transport pathway  (ISO) insulin signaling pathway  (IEA,ISO,ISS) maturity onset diabetes of the young pathway  (IEA) mTOR signaling pathway  (IEA) prostate cancer pathway  (IEA) type 1 diabetes mellitus pathway  (IEA) type 2 diabetes mellitus pathway  (IEA,ISS) External Database Links KEGG Pathway Aldosterone-regulated sodium reabsorption HIF-1 signaling pathway Insulin secretion Insulin signaling pathway Maturity onset diabetes of the young mTOR signaling pathway Oocyte meiosis PI3K-Akt signaling pathway Progesterone-mediated oocyte maturation Prostate cancer Regulation of actin cytoskeleton Regulation of autophagy Type I diabetes mellitus Type II diabetes mellitus Pathway Interaction Database Arf6 trafficking events (PID:200057) ATF-2 transcription factor network (PID:200135) FOXA1 transcription factor network (PID:200226) FOXA2 and FOXA3 transcription factor networks (PID:200087) Insulin Pathway (PID:200014) Insulin-mediated glucose transport (PID:200196) Signaling events mediated by PTP1B (PID:200042) Signaling events mediated by TCPTP (PID:200078) References - curated 1. Arias AE, etal., J Cell Sci. 2000 Jun;113 ( Pt 11):2075-83. 2. Brands MW, etal., Hypertension. 1997 Apr;29(4):1014-9. 3. Chan SJ, etal., Proc Natl Acad Sci U S A 1979 Oct;76(10):5036-40. 4. Collinet M, etal., Eur J Pediatr. 1998 Jun;157(6):456-60. 5. Colombo C, etal., J Clin Invest. 2008 Jun;118(6):2148-56. 6. Crabtree JS, etal., Mol Cell Biol. 2003 Sep;23(17):6075-85. 7. Currie CJ, etal., Diabetologia. 2009 Sep;52(9):1766-77. Epub 2009 Jul 2. 8. Fang D, etal., Endocr J. 2012;59(1):81-90. Epub 2011 Nov 9. 9. Fort PE, etal., PLoS One. 2011;6(10):e26498. Epub 2011 Oct 26. 10. Gastinger MJ, etal., Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3143-50. 11. Grunblatt E, etal., J Neurochem. 2007 May;101(3):757-70. 12. Guest PC, etal., J Endocrinol. 2002 Dec;175(3):637-47. 13. Holmkvist J, etal., PLoS One. 2009 Jun 11;4(6):e5872. 14. Hompesch M, etal., Diabetes Technol Ther. 2009 May;11(5):307-13. 15. Hunter SJ and Garvey WT, Am J Med. 1998 Oct;105(4):331-45. 16. Kao PC, etal., J Clin Endocrinol Metab. 1994 May;78(5):1048-51. 17. KEGG 18. Kolb A, etal., Cancer Biol Ther. 2009 Aug;8(16):1527-33. Epub 2009 Aug 13. 19. Kozak M Nature 1984 Mar 15-21;308(5956):241-6. 20. Krechler T, etal., Neoplasma. 2009;56(1):26-32. 21. Le Stunff C, etal., Nat Genet. 2000 Dec;26(4):444-6. 22. Li D, etal., Gastroenterology. 2009 Aug;137(2):482-8. Epub 2009 Apr 16. 23. Lomedico P, etal., Cell 1979 Oct;18(2):545-58. 24. Lomedico PT, etal., Ann N Y Acad Sci 1980;343:425-32. 25. Lu H, etal., J Gastroenterol Hepatol. 2009 Feb;24(2):228-32. Epub 2008 Aug 17. 26. Malide D, etal., J Histochem Cytochem. 1995 Jan;43(1):11-9. 27. MGD data from the GO Consortium 28. Navaneethan SD and Beddhu S, Nephrol Dial Transplant. 2009 Apr;24(4):1260-6. Epub 2008 Nov 25. 29. NCBI rat LocusLink and RefSeq merged data July 26, 2002 30. Olansky L, etal., J Clin Invest. 1992 May;89(5):1596-602. 31. Park SY, etal., Biochem Biophys Res Commun. 2010 Jan 15;391(3):1449-54. Epub 2009 Dec 23. 32. Peschke E, etal., J Pineal Res. 2006 Mar;40(2):184-91. 33. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 34. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 35. RGD automated data pipeline 36. RGD automated import pipeline for gene-chemical interactions 37. RGD Automated Pipelines 38. RGD comprehensive gene curation 39. Roth J, etal., Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;56(5):287-92. 40. Skyler JS, etal., Diabetes Res Clin Pract. 2008 Nov;82(2):238-46. Epub 2008 Sep 27. 41. Soares MB, etal., Mol Cell Biol 1985 Aug;5(8):2090-103. 42. Stoy J, etal., Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15040-4. Epub 2007 Sep 12. 43. Ward WK, etal., Diabetologia. 1987 Sep;30(9):698-702. 44. Yilmaz O, etal., J Diabetes Complications. 2009 Mar 6. 45. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91. 46. Zyromski NJ, etal., Surgery. 2009 Aug;146(2):258-63. References - uncurated PubMed 12038757   17993259   18063688   18165568   20857410   21773965   21821716   22161251   4311938   4554104   4640931 RGD Disease Portals Ins2 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Cardiovascular Diseases Cardiovascular Pathways Biological Process Diabetes Diseases Diabetes Pathways Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Biological Process Respiratory Pathways Genomics Candidate Gene Status Ins2 is a candidate Gene for Hcar4 Ins2 is a candidate Gene for Iddm25 Comparative Map Data Ins2   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   NCBI RGSC Genome Assembly v5.0 1 222,751,786 - 222,752,853 - NCBI RGSC Genome Assembly v3.4 1 202,935,548 - 202,936,379 - NCBI Rat Celera Assembly 1 195,461,309 - 195,462,376 - NCBI Genome Assembly 3.1 1 203,123,613 - 203,124,445 - NCBI INS   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 2,114,901 - 2,116,331 - NCBI Human Genome Assembly HuRef 11 1,971,272 - 1,972,702 - NCBI Human Genome Assembly GRCh37 11 2,181,009 - 2,182,439 - NCBI Human Genome Assembly Build 36 11 2,137,585 - 2,139,015 - NCBI Human Cytogenetic Map 11 p15.5   NCBI Human Genome Assembly 11 2,137,584 - 2,139,000   NCBI Ins2   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 7 142,678,656 - 142,679,708 - NCBI Mouse cM Map 7 88.0   NCBI Mouse Celera Assembly 7 142,434,985 - 142,436,037 - NCBI Mouse Genome Assembly Build 37 7 149,864,561 - 149,865,613 - NCBI Mouse Genome Assembly Build 36.1 7 149,864,566 - 149,865,613 - NCBI Mouse Cytogenetic Map 7 F5   NCBI Position Markers AA986540   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS Rat Cytogenetic Map 1 q54-q55   UniSTS RGSC Genome Assembly v5.0 1 280,214,020 - 280,214,158   UniSTS RGSC Genome Assembly v3.4 1 258,001,526 - 258,001,664   UniSTS Rat Celera Assembly 1 246,946,819 - 246,946,957   UniSTS PMC123023P1   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS Rat Cytogenetic Map 1 q54-q55   UniSTS RGSC Genome Assembly v5.0 1 280,213,826 - 280,214,034   UniSTS RGSC Genome Assembly v5.0 1 222,751,936 - 222,752,642   UniSTS RGSC Genome Assembly v3.4 1 258,001,332 - 258,001,540   UniSTS RGSC Genome Assembly v3.4 1 202,935,638 - 202,936,344   UniSTS Rat Celera Assembly 1 246,946,625 - 246,946,833   UniSTS Rat Celera Assembly 1 195,461,459 - 195,462,165   UniSTS PMC21231P1   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS Rat Cytogenetic Map 1 q54-q55   UniSTS RGSC Genome Assembly v5.0 1 280,213,799 - 280,214,099   UniSTS RGSC Genome Assembly v5.0 1 222,751,870 - 222,752,669   UniSTS RGSC Genome Assembly v3.4 1 258,001,305 - 258,001,605   UniSTS RGSC Genome Assembly v3.4 1 202,935,572 - 202,936,371   UniSTS Rat Celera Assembly 1 246,946,598 - 246,946,898   UniSTS Rat Celera Assembly 1 195,461,393 - 195,462,192   UniSTS PMC21334P1   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS Rat Cytogenetic Map 1 q54-q55   UniSTS RGSC Genome Assembly v5.0 1 280,213,853 - 280,214,081   UniSTS RGSC Genome Assembly v5.0 1 222,751,888 - 222,752,615   UniSTS RGSC Genome Assembly v3.4 1 258,001,359 - 258,001,587   UniSTS RGSC Genome Assembly v3.4 1 202,935,590 - 202,936,317   UniSTS Rat Celera Assembly 1 246,946,652 - 246,946,880   UniSTS Rat Celera Assembly 1 195,461,411 - 195,462,138   UniSTS RH94798   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS RGSC Genome Assembly v5.0 1 222,752,672 - 222,752,930   UniSTS RGSC Genome Assembly v3.4 1 202,936,374 - 202,936,632   UniSTS Rat Celera Assembly 1 195,462,195 - 195,462,453   UniSTS RH94799   Map Chr Position Strand Source Rat Cytogenetic Map 1 q54-q55   UniSTS Rat Cytogenetic Map 1 q41   UniSTS RGSC Genome Assembly v5.0 1 280,213,780 - 280,214,079   UniSTS RGSC Genome Assembly v5.0 1 222,751,890 - 222,752,688   UniSTS RGSC Genome Assembly v3.4 1 258,001,286 - 258,001,585   UniSTS RGSC Genome Assembly v3.4 1 202,935,592 - 202,936,390   UniSTS Rat Celera Assembly 1 246,946,579 - 246,946,878   UniSTS Rat Celera Assembly 1 195,461,413 - 195,462,211   UniSTS RH 3.4 1 1654.9   UniSTS D1Bda44   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS RGSC Genome Assembly v5.0 1 222,752,321 - 222,752,855   UniSTS RGSC Genome Assembly v3.4 1 202,936,023 - 202,936,557   UniSTS Rat Celera Assembly 1 195,461,844 - 195,462,378   UniSTS PMC123023P3   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS Rat Cytogenetic Map 1 q54-q55   UniSTS RGSC Genome Assembly v5.0 1 280,213,791 - 280,214,122   UniSTS RGSC Genome Assembly v5.0 1 222,751,847 - 222,752,677   UniSTS RGSC Genome Assembly v3.4 1 258,001,297 - 258,001,628   UniSTS RGSC Genome Assembly v3.4 1 202,935,549 - 202,936,379   UniSTS Rat Celera Assembly 1 246,946,590 - 246,946,921   UniSTS Rat Celera Assembly 1 195,461,370 - 195,462,200   UniSTS PMC153767P2   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS RGSC Genome Assembly v5.0 1 222,751,941 - 222,752,652   UniSTS RGSC Genome Assembly v3.4 1 202,935,643 - 202,936,354   UniSTS Rat Celera Assembly 1 195,461,464 - 195,462,175   UniSTS PMC24644P6   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS Rat Cytogenetic Map 1 q54-q55   UniSTS RGSC Genome Assembly v5.0 1 280,213,929 - 280,214,116   UniSTS RGSC Genome Assembly v5.0 1 222,751,853 - 222,752,539   UniSTS RGSC Genome Assembly v3.4 1 258,001,435 - 258,001,622   UniSTS RGSC Genome Assembly v3.4 1 202,935,555 - 202,936,241   UniSTS Rat Celera Assembly 1 246,946,728 - 246,946,915   UniSTS Rat Celera Assembly 1 195,461,376 - 195,462,062   UniSTS UniSTS:267003   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS Rat Cytogenetic Map 1 q54-q55   UniSTS RGSC Genome Assembly v5.0 1 280,213,904 - 280,214,121   UniSTS RGSC Genome Assembly v5.0 1 222,751,848 - 222,752,564   UniSTS RGSC Genome Assembly v3.4 1 258,001,410 - 258,001,627   UniSTS RGSC Genome Assembly v3.4 1 202,935,550 - 202,936,266   UniSTS Rat Celera Assembly 1 246,946,703 - 246,946,920   UniSTS Rat Celera Assembly 1 195,461,371 - 195,462,087   UniSTS UniSTS:462687   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS RGSC Genome Assembly v5.0 1 222,751,849 - 222,752,601   UniSTS RGSC Genome Assembly v3.4 1 202,935,551 - 202,936,303   UniSTS Rat Celera Assembly 1 195,461,372 - 195,462,124   UniSTS Ins1   Map Chr Position Strand Source Rat Cytogenetic Map 1 q54-q55   UniSTS Rat Cytogenetic Map 1 q41   UniSTS RGSC Genome Assembly v5.0 1 280,213,810 - 280,214,121   UniSTS RGSC Genome Assembly v5.0 1 222,751,848 - 222,752,658   UniSTS RGSC Genome Assembly v3.4 1 258,001,316 - 258,001,627   UniSTS RGSC Genome Assembly v3.4 1 202,935,550 - 202,936,360   UniSTS Rat Celera Assembly 1 246,946,609 - 246,946,920   UniSTS Rat Celera Assembly 1 195,461,371 - 195,462,181   UniSTS Ins2   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS RGSC Genome Assembly v5.0 1 222,751,839 - 222,751,962   UniSTS RGSC Genome Assembly v3.4 1 202,935,541 - 202,935,664   UniSTS Rat Celera Assembly 1 195,461,362 - 195,461,485   UniSTS Ins2   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS Rat Cytogenetic Map 1 q54-q55   UniSTS RGSC Genome Assembly v5.0 1 280,213,976 - 280,214,159   UniSTS RGSC Genome Assembly v3.4 1 258,001,482 - 258,001,665   UniSTS Rat Celera Assembly 1 246,946,775 - 246,946,958   UniSTS Ins1   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS RGSC Genome Assembly v5.0 1 222,751,883 - 222,752,854   UniSTS RGSC Genome Assembly v3.4 1 202,935,585 - 202,936,556   UniSTS Rat Celera Assembly 1 195,461,406 - 195,462,377   UniSTS QTLs in Region (RGSC Genome Assembly v3.4) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 631205 Bp196 Blood pressure QTL 196 4 .0001 Blood pressure mean arterial 1 119780561 204280278 Rat 631260 Tcas2 Tongue tumor susceptibility QTL 2 4.5 Tongue tumor susceptibility 1 197423292 204280406 Rat 634314 Niddm44 Non-insulin dependent diabetes mellitus QTL 44 Glucose level 1 43872827 204280278 Rat 1357335 Bw39 Body weight QTL 39 3.3 Body weight 1 202906624 247322277 Rat 1558658 Bw59 Body weight QTL 59 3.5 .0003 Body weight 1 184074275 229074275 Rat 1358294 Bw37 Body weight QTL 37 5 .000011 Body weight 1 176292515 221292515 Rat 1354661 Bw33 Body weight QTL 33 5.2 Body weight 1 154074905 263699089 Rat 1354610 Bw34 Body weight QTL 34 4.1 Body weight 1 154074905 263699089 Rat 1354602 Bw35 Body weight QTL 35 12.2 Body weight 1 154074905 206567907 Rat 61455 Niddm7 Non-insulin dependent diabetes mellitus QTL 7 5.5 Glucose level 1 198139596 243139596 Rat 70163 Bw20 Body weight QTL 20 5.1 Body weight 1 178054386 247322277 Rat 631549 Bp89 Blood pressure QTL 89 5.7 Blood pressure 1 124614852 206574205 Rat 61376 Bp42 Blood pressure QTL 42 23.4 Blood pressure 1 202906624 247322277 Rat 631658 Cm7 Cardiac mass QTL 7 5.32 .0001 Cardiac mass aorta 1 201920676 246920676 Rat 731168 Bp154 Blood pressure QTL 154 3.4 Blood pressure systolic 1 94624828 220639653 Rat 634338 Hcar4 Hepatocarcinoma resistance QTL 4 4.6 Liver tumor resistance 3-methyl-4-dimethylaminoazobenzene induced 1 198396580 220639653 Rat 634312 Bp143 Blood pressure QTL 143 3 .0002 Blood pressure systolic 1 198853034 225625256 Rat 634321 Hc1 Hypercalciuria QTL 1 2.91 Renal function calcium excretion 1 183163129 248833756 Rat 724531 Uae5 Urinary albumin excretion QTL 5 4 Renal function urine albumin level 1 153578442 259173490 Rat 724559 Pancm1 Pancreatic morphology QTL 1 7.1 Pancreatic morphology 1 186391887 220639539 Rat 737828 Hcas3 Hepatocarcinoma susceptibility QTL 3 4.9 Liver tumor susceptibility nodule number 1 146971846 228781113 Rat 738032 Hcas5 Hepatocarcinoma susceptibility QTL 5 3.12 Liver tumor susceptibility nodule number 1 180678929 265343617 Rat 1298084 Thym4 Thymus enlargement QTL 4 10.68 Gland mass thymus 1 202906624 247906624 Rat 1354618 Kidm15 Kidney mass QTL 15 5 Kidney mass left kidney mass 1 159782445 206567907 Rat 1300145 Rf7 Renal function QTL 7 2.96 Renal function salt-loaded urine creatinine concentration 1 189900686 227005733 Rat 70209 Niddm23 Non-insulin dependent diabetes mellitus QTL 23 2.82 Glucose level fasting 1 94473940 203416143 Rat 1354580 Scort1 Serum corticosterone level QTL 1 3.4 Hormone level corticosterone 1 159782445 263699089 Rat 1354606 Bp246 Blood pressure QTL 246 3.6 Blood pressure pulse pressure 1 103149923 224426393 Rat 1354652 Kidm20 Kidney mass QTL 20 4.3 Kidney mass left kidney mass adjusted for body weight 1 181524849 263699089 Rat 1354653 Despr9 Despair related QTL 9 .00019 Activity level climbing level 1 172723568 217723568 Rat 1354620 Kidm19 Kidney mass QTL 19 4 Kidney mass left kidney mass adjusted for tibia length 1 154074905 206567907 Rat 1354624 Cm35 Cardiac mass QTL35 5.7 Cardiac mass left ventricle adjusted for body weight 1 181524849 263699089 Rat 1354591 Cm36 Cardiac mass QTL 36 4.1 Cardiac mass left ventricle adjusted for tibia length 1 103149923 206567907 Rat 1354634 Kidm12 Kidney mass QTL 12 3.9 Kidney mass right kidney mass 1 154074905 206567907 Rat 1354615 Cm32 Cardiac mass QTL 32 5.2 Cardiac mass left ventricle 1 103149923 206567907 Rat 1331749 Hrtrt11 Heart rate QTL 11 2.973 Heart rate 1 94473940 203303100 Rat 1358191 Ept10 Estrogen-induced pituitary tumorigenesis QTL 10 3.8 Gland mass pituitary 1 197770157 250119666 Rat 1358292 Cm37 Cardiac mass QTL 37 6.2 .00000081 Cardiac mass cardiac mass index 1 201920676 246920676 Rat 1354636 Lmblg1 Limb length QTL 1 6.4 Limb morphology tibia length 1 154074905 206567907 Rat 1354646 Kidm18 Kidney mass QTL 18 5.7 Kidney mass right kidney mass adjusted for body weight 1 154074905 263699089 Rat 1358886 Bp260 Blood pressure QTL 260 3.67 Blood pressure post nitric oxide system block 1 154075310 231726050 Rat 1358898 Bp255 Blood pressure QTL 255 3.6 Blood pressure post nitric oxide system block 1 195927908 252497797 Rat 1359018 Hrtrt20 Heart rate QTL 20 3.08 Heart rate stress-induced tachycardia 1 190114247 208110419 Rat 1549837 Hcar15 Hepatocarcinoma resistance QTL 15 .05 Liver tumor resistance 3-methyl-4-dimethylaminoazobenzene induced 1 156124624 247322277 Rat 2312420 Pur17 Proteinuria QTL 17 7.1 .0001 Renal function urine protein level 1 159782445 224426393 Rat 2312564 Glom18 Glomerulus QTL 18 2.4 .003 Renal pathology 1 190114247 238037551 Rat 1582206 Kidm33 Kidney mass QTL 33 6.9 Kidney mass 1 193069836 229876997 Rat 1598853 Memor3 Memory QTL 3 4.5 Memory navigation-spatial 1 146189650 218467340 Rat 1578759 Uae30 Urinary albumin excretion QTL 30 3.3 .003 Renal function urine albumin level 1 183946692 267910886 Rat 1578763 Kidm29 Kidney mass QTL 29 3.3 .0001 Kidney mass 1 183946692 267910886 Rat 1578780 Cm52 Cardiac mass QTL 52 3.3 .0001 Cardiac mass 1 81342810 225814178 Rat 1600396 Niddm68 Non-insulin dependent diabetes mellitus QTL 68 4.97 .0003 Glucose level 1 200882874 264367394 Rat 1600388 Niddm67 Non-insulin dependent diabetes mellitus QTL 67 5.84 .000004 Glucose level 1 200882874 264367394 Rat 1641926 Teswt2 Testicular weight QTL 2 2.82 Testicular weight 1 202790380 247790380 Rat 2293693 Bss22 Bone structure and strength QTL 22 33.52 .0001 Bone structure 1 176612333 221612333 Rat 2293654 Bss30 Bone structure and strength QTL 30 32.65 .0001 Bone structure 1 176612333 221612333 Rat 2292220 Bp306 Blood pressure QTL 306 3.47 .00087 Blood pressure systolic 1 167931220 250119874 Rat 2292222 Bp307 Blood pressure QTL 307 3.06 .0014 Blood pressure systolic 1 167931220 219629888 Rat 2293083 Iddm25 Insulin dependent diabetes mellitus QTL 25 3.03 Glucose level insulin-dependent 1 186471692 230411453 Rat 1600374 Mcs17 Mammary carcinoma susceptibility QTL 17 3 Mammary tumor susceptibility 1 202763018 247763018 Rat 1600363 Hc6 Hypercalciuria QTL 6 2.7 Renal function calcium excretion 1 112148733 250430505 Rat 1600395 Niddm69 Non-insulin dependent diabetes mellitus QTL 69 4.14 .0002 Insulin level 1 200882874 264367394 Rat 1600380 Niddm70 Non-insulin dependent diabetes mellitus QTL 70 3.1 .0008 Insulin level 1 181780342 226780342 Rat 2302375 Bw83 Body weight QTL 83 4.87 .0002 Body weight 1 202790380 247322277 Rat 2302378 Insul11 Insulin level QTL 11 3.25 Insulin level 1 146971846 247322277 Rat 2303622 Vencon6 Ventilatory control QTL 6 .001 Ventilatory control re-oxygenation after hypoxia 1 158856292 203856292 Rat 2300187 Bmd41 Bone mineral density QTL 41 8.9 .0001 Bone mineral density 1 176612333 221612333 Rat 2300161 Bmd43 Bone mineral density QTL 43 8.4 .0001 Bone mineral density 1 176612333 221612333 Rat 2300174 Bmd42 Bone mineral density QTL 42 8.4 .0001 Bone mineral density 1 176612333 221612333 Rat 2293673 Bss27 Bone structure and strength QTL 27 18.63 .0001 Bone structure 1 176612333 221612333 Rat 2293689 Bss47 Bone structure and strength QTL 47 7.25 .0001 Bone structure 1 176612333 221612333 Rat 2293677 Bss41 Bone structure and strength QTL 41 9.38 .0001 Bone structure 1 176612333 221612333 Rat 6480777 Insul17 Insulin level QTL 17 3.86 Insulin level 1 202350579 203303100 Rat 1302787 Stl25 Serum triglyceride level QTL 25 2.7 .0073 Lipid level triglyceride level 1 184857716 216663271 Rat 6903303 Scl34 Serum cholesterol QTL 34 2.5 .0033 Lipid level cholesterol level 1 184857716 223729371 Rat 6480780 Insul18 Insulin level QTL 18 4.11 Insulin level fasting 1 198853034 205897680 Rat 6480783 Insul19 Insulin level QTL 19 4.33 Insulin level sensitivity 1 198853034 205897680 Rat 1549830 Bss1 Bone structure and strength QTL 1 4.8 Bone strength Femoral ultimate force 1 177666790 222666790 Rat 631837 Niddm35 Non-insulin dependent diabetes mellitus QTL 35 .01 Insulin level 1 190677683 235677683 Rat 61347 Bp197 Blood pressure QTL 197 4.2 Blood pressure systolic blood pressure 1 163190108 208190108 Rat 61345 Rf1 Renal disease susceptibility QTL 1 8.9 Renal function urine protein excretion rate 1 202322277 247322277 Rat Sequence Nucleotide Sequences Nucleotide RefSeqs NM_019130 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AABR06009393 (Get FASTA) Search GEO for Microarray Profiles   AAHX01009101 (Get FASTA) Search GEO for Microarray Profiles   AC098563 (Get FASTA) Search GEO for Microarray Profiles   BP467629 (Get FASTA) Search GEO for Microarray Profiles   BP472188 (Get FASTA) Search GEO for Microarray Profiles   BP485158 (Get FASTA) Search GEO for Microarray Profiles   CH473953 (Get FASTA) Search GEO for Microarray Profiles   J00748 (Get FASTA) Search GEO for Microarray Profiles   M25583 (Get FASTA) Search GEO for Microarray Profiles   M25585 (Get FASTA) Search GEO for Microarray Profiles   V01243 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_019130 RefSeq Status: VALIDATED Type: CODING Protein Acc Id: NP_062003 Peptide Label: preproprotein Position: Map Chr Position Strand Source RGSC Genome Assembly v5.0 1 222,751,786 - 222,752,853 - NCBI RGSC Genome Assembly v3.4 1 202,935,548 - 202,936,379 - RGD Rat Celera Assembly 1 195,461,309 - 195,462,376 - NCBI Protein Sequences Protein RefSeqs NP_062003 (Get FASTA) GenBank Protein AAA41440 (Get FASTA)   AAA41443 (Get FASTA)   CAA24560 (Get FASTA)   EDM12162 (Get FASTA)   P01323 (Get FASTA) Promoters RGD ID: 6850050 Promoter ID: EP17070 Type: single initiation site Name: RN_INS2 Description: Insulin II, INS2 or INS-2 gene. SO ACC ID: SO:0000170 Source: EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Notes: homology_group=Homology group 45; Mammalian insulin. Experiment Methods: Nuclease protection; experiments performed with closely related; gene; Primer extension; experiments performed with closely related; gene; Nuclease protection; transfected or transformed cells; experiments; performed with closely related gene; Primer extension; transfected or transformed cells; experiments; performed with closely related gene Regulation: pancreas islet b' (repressed by or weakly expressed in) cells; (induced by or strongly expressed in) glucose Position: Map Chr Position Strand Source RGSC Genome Assembly v3.4 1 202,936,557 - 202,936,617   EPD Strain Variation Strain Sequence Variants ACI/Eur (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 ACI/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN-Lx (ICL) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: SOLID Secondary Analysis: BWA, GATK, Samtools Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: MC-A654-5QB00 BN-Lx (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/NHsdMcwi (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/SsN (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Buf/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) COP/Crl (MCW & UW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Univiersity of Wisconsin (Jim Shull) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 Breeder: Charles River Grant Information: NIH (CA77876) F344/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHH/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 FHH/EurMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHL/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 GH/OmrMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 LE/Stm (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Dr. Tadao Serikawa, Kyoto Japan. Grant Information: EURATRANS (HEALTH-F4-2010-241504) M520/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) MR/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHR/Olalpcv (ICL) Visual CSV TAB Printer Sequenced By: Imperial College London (Dr Timothy Aitman) University of British Columbia (Dr. Steven Jones) Platform: Illumina Hi-seq 2000 and GAII Secondary Analysis: BWA, GATK Breeder: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague Grant Information: LSHG-CT-2005-019015, HEALTH-F4-2010-241504 SHR/Olalpcv (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: Illumina Secondary Analysis: GATK Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHRSP/Gcrc (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruch Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: University of Glasgow, Anna Dominiczak Grant Information: EURATRANS (HEALTH-F4-2010-241504) SR/JrHsd (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Breeder: Harlan SS/JrHsdMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Grant Information: R01 HL089930 SS/JrHsdMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) WKY/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) WN/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSRNOG00000020405 ENTREZGENE, UniProtKB/Swiss-Prot Ensembl Protein ENSRNOP00000027656 ENTREZGENE, UniProtKB/Swiss-Prot Ensembl Transcript ENSRNOT00000027656 ENTREZGENE, UniProtKB/Swiss-Prot Entrez Gene 24506 ENTREZGENE Gene3D-CATH Ins/IGF/relaxin UniProtKB/Swiss-Prot Germonline ENSRNOG00000020405 UniProtKB/Swiss-Prot HomoloGene Group ID 173 ENTREZGENE InterPro Insulin-like UniProtKB/Swiss-Prot   Insulin_chordata UniProtKB/Swiss-Prot   Insulin_CS UniProtKB/Swiss-Prot   Insulin_family UniProtKB/Swiss-Prot IPI IPI00212593 UniProtKB/Swiss-Prot KEGG Report rno:24506 ENTREZGENE, UniProtKB/Swiss-Prot Pfam Insulin UniProtKB/Swiss-Prot PRINTS INSULIN UniProtKB/Swiss-Prot   INSULINFAMLY UniProtKB/Swiss-Prot PROSITE INSULIN UniProtKB/Swiss-Prot SMART IlGF UniProtKB/Swiss-Prot Superfamily-SCOP Insulin-like UniProtKB/Swiss-Prot UniGene Rn.989 ENTREZGENE UniProt INS2_RAT UniProtKB/Swiss-Prot Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2002-11-06 Ins2  insulin 2    Insulin 2  Name updated 2225 APPROVED 2002-06-10 Ins2  Insulin 2      Symbol and Name status set to approved 1490 APPROVED RGD Curation Notes Note Type Note Reference gene_transcript contains two introns 729274

More on Ins2 Entrez Gene Ensembl Gene Genome Browser NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 2916 Created: 2000-05-25 Species: Rattus norvegicus Last Modified: 2013-04-16 Status: ACTIVE