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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PPP3CA mRNA | CTD | PMID:20068009 | 17beta-estradiol | decreases expression | ISO | RGD:730900 | 6480464 | Estradiol results in decreased expression of PPP3CA mRNA | CTD | PMID:21185374 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PPP3CA mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:11134 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PPP3CA mRNA | CTD | PMID:21570461 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of PPP3CA mRNA | CTD | PMID:21346803 | 2-deoxy-D-glucose | decreases response to substance | ISO | RGD:11134 | 6480464 | PPP3CA protein results in decreased susceptibility to Deoxyglucose | CTD | PMID:10679475 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in decreased expression of PPP3CA mRNA | CTD | PMID:19162173 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:11134 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of PPP3CA mRNA | CTD | PMID:18648102 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:730900 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of PPP3CA mRNA | CTD | PMID:12419474 | 5-fluorouracil | multiple interactions | ISO | RGD:730900 | 6480464 | [Fluorouracil co-treated with irinotecan] results in increased expression of PPP3CA mRNA | CTD | PMID:16391804 | 5-fluorouracil | increases expression | ISO | RGD:730900 | 6480464 | Fluorouracil results in increased expression of PPP3CA protein | CTD | PMID:15585135 PMID:16803524 | 5-fluorouracil | multiple interactions | ISO | RGD:730900 | 6480464 | PPP3CA protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog] | CTD | PMID:18927307 | 5-fluorouracil | increases expression | ISO | RGD:730900 | 6480464 | Fluorouracil results in increased expression of PPP3CA protein | CTD | PMID:16803524 PMID:15585135 | acetazolamide | increases expression | ISO | RGD:11134 | 6480464 | Acetazolamide results in increased expression of PPP3CA mRNA | CTD | PMID:19274763 | aflatoxin B1 | decreases expression | ISO | RGD:11134 | 6480464 | Aflatoxin B1 results in decreased expression of PPP3CA mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | decreases expression | ISO | RGD:730900 | 6480464 | Tretinoin results in decreased expression of PPP3CA mRNA | CTD | PMID:16140955 | all-trans-retinoic acid | decreases expression | ISO | RGD:730900 | 6480464 | Tretinoin results in decreased expression of PPP3CA mRNA | CTD | PMID:21934132 PMID:16140955 | all-trans-retinoic acid | decreases expression | ISO | RGD:730900 | 6480464 | Tretinoin results in decreased expression of PPP3CA mRNA | CTD | PMID:16140955 PMID:21934132 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PPP3CA mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | ISO | RGD:730900 | 6480464 | Benzo(a)pyrene results in decreased expression of PPP3CA mRNA | CTD | PMID:20064835 PMID:20106945 | benzo[a]pyrene | decreases expression | ISO | RGD:730900 | 6480464 | Benzo(a)pyrene results in decreased expression of PPP3CA mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene | decreases expression | ISO | RGD:730900 | 6480464 | Benzo(a)pyrene results in decreased expression of PPP3CA mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene | decreases expression | ISO | RGD:11134 | 6480464 | Benzo(a)pyrene results in decreased expression of PPP3CA mRNA | CTD | PMID:21715664 PMID:20504355 | benzo[a]pyrene | decreases expression | ISO | RGD:730900 | 6480464 | Benzo(a)pyrene results in decreased expression of PPP3CA mRNA | CTD | PMID:20106945 PMID:20064835 | benzo[a]pyrene | decreases expression | ISO | RGD:11134 | 6480464 | Benzo(a)pyrene results in decreased expression of PPP3CA mRNA | CTD | PMID:20504355 PMID:21715664 | benzo[a]pyrene | multiple interactions | ISO | RGD:11134 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of PPP3CA mRNA | CTD | PMID:21715664 | benzyl acetate | multiple interactions | ISO | RGD:730900 | 6480464 | benzyl acetate results in increased cleavage of and results in increased activity of PPP3CA protein | CTD | PMID:22952646 | bis(2-chloroethyl) sulfide | multiple interactions | ISO | RGD:11134 | 6480464 | Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP3CA mRNA] | CTD | PMID:16377760 | bis(2-chloroethyl) sulfide | affects expression | EXP | | 6480464 | Mustard Gas affects the expression of PPP3CA mRNA | CTD | PMID:15651846 | bis(2-chloroethyl) sulfide | decreases expression | ISO | RGD:11134 | 6480464 | Mustard Gas results in decreased expression of PPP3CA mRNA | CTD | PMID:16377760 | cadmium dichloride | increases expression | ISO | RGD:730900 | 6480464 | Cadmium Chloride results in increased expression of PPP3CA mRNA | CTD | PMID:12160620 | cadmium dichloride | decreases expression | ISO | RGD:730900 | 6480464 | Cadmium Chloride results in decreased expression of PPP3CA mRNA | CTD | PMID:18560533 | calcitriol | increases expression | ISO | RGD:730900 | 6480464 | Calcitriol results in increased expression of PPP3CA mRNA | CTD | PMID:16002434 | capsaicin | multiple interactions | EXP | | 6480464 | PPP3CA protein affects the reaction [mustard oil inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]] | CTD | PMID:17590514 | carbamazepine | decreases expression | EXP | | 6480464 | Carbamazepine results in decreased expression of PPP3CA mRNA; more ... | CTD | PMID:14642444 | chlorpyrifos | increases expression | ISO | RGD:11134 | 6480464 | Chlorpyrifos results in increased expression of PPP3CA mRNA | CTD | PMID:20350560 | cisplatin | multiple interactions | ISO | RGD:730900 | 6480464 | [Piroxicam co-treated with Cisplatin] results in decreased expression of PPP3CA mRNA | CTD | PMID:21858171 | clozapine | multiple interactions | EXP | | 6480464 | [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein | CTD | PMID:16033416 | clozapine | increases expression | EXP | | 6480464 | Clozapine results in increased expression of PPP3CA mRNA | CTD | PMID:12437575 | clozapine | decreases expression | EXP | | 6480464 | Clozapine results in decreased expression of PPP3CA mRNA; more ... | CTD | PMID:16033416 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of PPP3CA mRNA | CTD | PMID:20187946 | cyclosporin A | decreases activity | ISO | RGD:11134 | 6480464 | Cyclosporine results in decreased activity of PPP3CA protein | CTD | PMID:19553475 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of PPP3CA protein | CTD | PMID:18344631 | cypermethrin | multiple interactions | ISO | RGD:730900 | 6480464 | [cypermethrin results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin | CTD | PMID:10898953 | dimercaprol | multiple interactions | ISO | RGD:11134 | 6480464 | Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP3CA mRNA] | CTD | PMID:16377760 | ethanol | multiple interactions | ISO | RGD:11134 | 6480464 | ALDH2 protein inhibits the reaction [Ethanol results in increased expression of PPP3CA protein] | CTD | PMID:19332462 | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of PPP3CA mRNA | CTD | PMID:20655511 | ethanol | increases expression | ISO | RGD:11134 | 6480464 | Ethanol results in increased expression of PPP3CA protein | CTD | PMID:19332462 | fenofibrate | multiple interactions | ISO | RGD:11134 | 6480464 | PPARA protein affects the reaction [Fenofibrate results in decreased expression of PPP3CA mRNA] | CTD | PMID:21318169 | fenofibrate | decreases expression | ISO | RGD:11134 | 6480464 | Fenofibrate results in decreased expression of PPP3CA mRNA | CTD | PMID:21318169 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of PPP3CA mRNA | CTD | PMID:20562052 | haloperidol | decreases expression | EXP | | 6480464 | Haloperidol results in decreased expression of PPP3CA mRNA; more ... | CTD | PMID:16033416 | haloperidol | multiple interactions | EXP | | 6480464 | [Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein | CTD | PMID:16033416 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of PPP3CA protein | CTD | PMID:15644446 | methamphetamine | multiple interactions | EXP | | 6480464 | SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PPP3CA protein] | CTD | PMID:15644446 | methotrexate | affects response to substance | ISO | RGD:730900 | 6480464 | PPP3CA protein affects the susceptibility to Methotrexate | CTD | PMID:16217747 | nitric oxide | decreases expression | ISO | RGD:11134 | 6480464 | Nitric Oxide deficiency results in decreased expression of PPP3CA mRNA | CTD | PMID:15878706 | paracetamol | affects expression | ISO | RGD:11134 | 6480464 | Acetaminophen affects the expression of PPP3CA mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:730900 | 6480464 | Acetaminophen results in increased expression of PPP3CA mRNA | CTD | PMID:21420995 | perfluorooctane-1-sulfonic acid | increases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in increased expression of PPP3CA mRNA | CTD | PMID:20136073 | perindopril | decreases expression | EXP | | 6480464 | Perindopril results in decreased expression of PPP3CA protein | CTD | PMID:18344631 | phenobarbital | decreases expression | ISO | RGD:11134 | 6480464 | Phenobarbital results in decreased expression of PPP3CA mRNA | CTD | PMID:19363144 | phenobarbital | affects expression | ISO | RGD:11134 | 6480464 | Phenobarbital affects the expression of PPP3CA mRNA | CTD | PMID:23091169 | pirinixic acid | decreases expression | ISO | RGD:11134 | 6480464 | pirinixic acid results in decreased expression of PPP3CA mRNA | CTD | PMID:21318169 | pirinixic acid | multiple interactions | ISO | RGD:11134 | 6480464 | PPARA protein affects the reaction [pirinixic acid results in decreased expression of PPP3CA mRNA] | CTD | PMID:21318169 | piroxicam | multiple interactions | ISO | RGD:730900 | 6480464 | [Piroxicam co-treated with Cisplatin] results in decreased expression of PPP3CA mRNA | CTD | PMID:21858171 | propiconazole | decreases expression | ISO | RGD:11134 | 6480464 | propiconazole results in decreased expression of PPP3CA mRNA | CTD | PMID:19363144 | quercetin | decreases expression | ISO | RGD:730900 | 6480464 | Quercetin results in decreased expression of PPP3CA mRNA | CTD | PMID:21632981 | risperidone | multiple interactions | EXP | | 6480464 | [Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein | CTD | PMID:16033416 | risperidone | decreases expression | EXP | | 6480464 | Risperidone results in decreased expression of PPP3CA mRNA; more ... | CTD | PMID:16033416 | S-butyl-DL-homocysteine (S,R)-sulfoximine | increases expression | ISO | RGD:11134 | 6480464 | Buthionine Sulfoximine results in increased expression of PPP3CA mRNA | CTD | PMID:15878706 | staurosporine | decreases response to substance | ISO | RGD:11134 | 6480464 | PPP3CA protein results in decreased susceptibility to Staurosporine | CTD | PMID:10679475 | staurosporine | increases cleavage | ISO | RGD:730900 | 6480464 | Staurosporine results in increased cleavage of PPP3CA protein | CTD | PMID:10898953 | tacrolimus hydrate | multiple interactions | ISO | RGD:730900 | 6480464 | [Tacrolimus results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin | CTD | PMID:10898953 | tacrolimus hydrate | decreases activity | ISO | RGD:11134 | 6480464 | Tacrolimus results in decreased activity of PPP3CA protein | CTD | PMID:19553475 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:730900 | 6480464 | tert-Butylhydroperoxide results in decreased expression of PPP3CA mRNA | CTD | PMID:12419474 | thapsigargin | multiple interactions | ISO | RGD:730900 | 6480464 | [cypermethrin results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin; more ... | CTD | PMID:10898953 | thapsigargin | increases cleavage | ISO | RGD:730900 | 6480464 | Thapsigargin results in increased cleavage of PPP3CA protein | CTD | PMID:10898953 | tocopherol | increases expression | ISO | RGD:11134 | 6480464 | Tocopherols results in increased expression of PPP3CA mRNA | CTD | PMID:17654050 | trichloroethene | multiple interactions | ISO | RGD:11134 | 6480464 | PPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of PPP3CA mRNA] | CTD | PMID:15363585 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of PPP3CA mRNA | CTD | PMID:19448997 | tunicamycin | increases expression | ISO | RGD:11134 | 6480464 | Tunicamycin results in increased expression of PPP3CA mRNA | CTD | PMID:17127020 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Alzheimer's disease |
| Amphetamine addiction | |
| Amyotrophic lateral sclerosis (ALS) | |
| Apoptosis | |
| Axon guidance | |
| B cell receptor signaling pathway | |
| Calcium signaling pathway | |
| Dopaminergic synapse | |
| Glutamatergic synapse | |
| HTLV-I infection | |
| Long-term potentiation | |
| MAPK signaling pathway | |
| Natural killer cell mediated cytotoxicity | |
| Oocyte meiosis | |
| Osteoclast differentiation | |
| T cell receptor signaling pathway | |
| Tuberculosis | |
| VEGF signaling pathway | |
| Wnt signaling pathway | |
| Pathway Interaction Database | BCR signaling pathway (PID:200006) |
| C-MYB transcription factor network (PID:200153) | |
| Calcium signaling in the CD4+ TCR pathway (PID:200185) | |
| Downstream signaling in naïve CD8+ T cells (PID:200215) | |
| IL12 signaling mediated by STAT4 (PID:200229) | |
| IL12-mediated signaling events (PID:200045) | |
| Role of Calcineurin-dependent NFAT signaling in lymphocytes (PID:200090) | |
Phenotype Annotations
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References - curated| 1. |
Abe T, etal., Brain Res. 2004 May 29;1009(1-2):159-68. |
| 2. |
Agbas A, etal., Brain Res. 2005 Oct 12;1059(1):59-71. Epub 2005 Sep 8. |
| 3. |
Bales JW, etal., J Neurotrauma. 2010 Jan;27(1):109-20. |
| 4. |
Dupont-Versteegden EE, etal., Am J Physiol Cell Physiol 2002 Jun;282(6):C1387-95. |
| 5. |
Gillis AM, etal., Cardiovasc Res. 2004 Dec 1;64(3):488-95. |
| 6. |
GOA data from the GO Consortium |
| 7. |
Gooch JL, etal., Am J Physiol Renal Physiol 2003 Jan;284(1):F144-54. |
| 8. |
Ito A, etal., Biochem Biophys Res Commun 1989 Sep 29;163(3):1492-7. |
| 9. |
KEGG |
| 10. |
Koulmann N, etal., Am J Respir Crit Care Med. 2006 Jun 23;. |
| 11. |
Lin XH, etal., Synapse 2002 Jun 1;44(3):181-7. |
| 12. |
Mansuy IM, etal., Cell 1998 Jan 9;92(1):39-49. |
| 13. |
MGD data from the GO Consortium |
| 14. |
Molkentin JD, etal., Cell. 1998 Apr 17;93(2):215-28. |
| 15. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 16. |
Perrino BA, etal., Eur J Biochem 2002 Jul;269(14):3540-8. |
| 17. |
Perrino BA, etal., J Biol Chem 1992 Aug 5;267(22):15965-9. |
| 18. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 19. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 20. |
RGD automated import pipeline for gene-chemical interactions |
| 21. |
Rodriguez A, etal., J Biol Chem. 2005 Mar 18;280(11):9980-4. Epub 2005 Jan 25. |
| 22. |
Shibasaki F and McKeon F, J Cell Biol. 1995 Nov;131(3):735-43. |
| 23. |
Vega RB, etal., Proc Natl Acad Sci U S A 2003 Jan 21;100(2):669-74. Epub 2003 Jan 6. |
| 24. |
Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91. |
| 25. |
Woolley SM, etal., J Thorac Cardiovasc Surg. 2004 Feb;127(2):376-84. |
| 26. |
Xifro X, etal., Neurobiol Dis. 2009 Dec;36(3):461-9. Epub 2009 Sep 4. |
References - uncurated| PubMed | 10593895 |
| 1335233 | |
| 14704270 | |
| 15153553 | |
| 16103353 | |
| 17303652 | |
| 18398669 | |
| 18600431 | |
| 18957384 | |
| 19717566 | |
| 19883655 | |
| 19916857 | |
| 19965390 | |
| 20051248 | |
| 20132097 | |
| 20359506 | |
| 20654708 | |
| 21440552 | |
| 21596102 | |
| 21730063 | |
| 21740891 | |
| 2174876 | |
| 21784900 | |
| 22305959 | |
| 23139767 | |
| 23261540 |
RGD Disease Portals| Ppp3ca has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Ppp3ca (Rattus norvegicus) |
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| PPP3CA (Homo sapiens) |
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| Ppp3ca (Mus musculus) |
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Position Markers| J05479 |
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| BF415569 |
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| SHGC-67255 |
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| RH142476 |
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| RH137817 |
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| RH138256 |
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| BF416075 |
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| BE119888 |
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| PPP3CA |
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| PPP3CA |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_017041 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06020947 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06020948 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06020949 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06020950 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06020951 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06020952 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06020953 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06020954 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06020955 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01010430 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01010431 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01010432 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01010433 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01010434 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01010435 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01010436 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01010437 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01010438 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01010439 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01010440 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY724517 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473952 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D90035 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ212355 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ212817 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M29275 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M58440 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X57115 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_017041 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058737 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_058737 | (Get FASTA) |
| GenBank Protein | AAA40940 | (Get FASTA) |
| AAA41914 | (Get FASTA) | |
| BAA14083 | (Get FASTA) | |
| CAA40398 | (Get FASTA) | |
| EDL82280 | (Get FASTA) | |
| EDL82281 | (Get FASTA) | |
| EDL82282 | (Get FASTA) | |
| EDL82283 | (Get FASTA) | |
| P63329 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000009882 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000049674 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000047975 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 24674 | ENTREZGENE |
| Germonline | ENSRNOG00000009882 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 55497 | ENTREZGENE |
| InterPro | M-pesterase | UniProtKB/Swiss-Prot |
| Ser/Thr-sp_prot-phosphatase | UniProtKB/Swiss-Prot | |
| IPI | IPI00201410 | UniProtKB/Swiss-Prot |
| IPI00559849 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:24674 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | Metallophos | UniProtKB/Swiss-Prot |
| PRINTS | STPHPHTASE | UniProtKB/Swiss-Prot |
| PROSITE | SER_THR_PHOSPHATASE | UniProtKB/Swiss-Prot |
| SMART | PP2Ac | UniProtKB/Swiss-Prot |
| UniGene | Rn.6866 | ENTREZGENE |
| UniProt | PP2BA_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-06-26 | Ppp3ca | protein phosphatase 3, catalytic subunit, alpha isozyme | Ppp3ca | protein phosphatase 3, catalytic subunit, alpha isoform | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2010-04-23 | Ppp3ca | protein phosphatase 3, catalytic subunit, alpha isoform | Ppp3ca | protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-12-15 | Ppp3ca | protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform | Ppp3ca | protein phosphatase 3, catalytic subunit, alpha isoform | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2001-10-24 | Ppp3ca | protein phosphatase 3, catalytic subunit, alpha isoform | Name updated to reflect Human and Mouse nomenclature | 853 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | inhibition results in whole kidney hypertrophy and abolishes glomerular hypertrophy in diabetic rats | 628556 |
| gene_drugs | cyclosporin acts as a inhibitor partially blocking the muscle size | 628556 |
| gene_drugs | cyclosporin A affects protein accumulation and activity | 628556 |
| gene_function | serine/threonine phosphatase | 628556 |
| gene_process | may play an important role in glomerular hypertrophy and extracellular matrix accumulation in deabetic nephropathy | 628556 |
| gene_process | mediates T cell signal transduction | 628556 |
| gene_process | mediates hypertropic response of muscle cells | 628556 |
| gene_process | catalytic and calmodulin binding phosphatase subunit is activated by intracellular calcium anions | 628398 |
| gene_process | increases phosphatase activity by binding to calcium and calmodulin | |
| gene_protein | alpha:beta and CaN:substrate ratios may determine the levels of phosphatase activity toward specific substrates | 729536 |
| gene_protein | heterodimer of 58-64 kDa | 628398 |
| gene_regulation | activated by intracellular calcuim and dephosphorylates nuclear factors of activated T cells (NFATs) | 628556 |
| More on Ppp3ca | |
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| RGD Object Information | |
| RGD ID: | 3382 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




