Gene: Tyr (tyrosinase) Rattus norvegicus
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Symbol: Tyr
Name: tyrosinase
Description: ENCODES a protein that exhibits monophenol monooxygenase activity; copper ion binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN pigmentation; response to cAMP; response to UV; PARTICIPATES IN alkaptonuria disease pathway; disulfiram pharmacodynamics pathway; dopamine beta hydroxylase deficiency pathway; ASSOCIATED WITH absent coat pigmentation; ASSOCIATED WITH Albinism; Albinism, Oculocutaneous; oculocutaneous albinism; FOUND IN cytosol; nucleus; cytoplasm (ortholog); INTERACTS WITH actinomycin D; phenylephrine; prazosin
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C; Tyr_mapped; tyrosinase (albino coat color) (mapped)
Orthologs:
Homo sapiens (human) : TYR (tyrosinase)  HGNC  AGR
Mus musculus (house mouse) : Tyr (tyrosinase)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Tyr (tyrosinase)
Pan paniscus (bonobo/pygmy chimpanzee) : TYR (tyrosinase)
Canis lupus familiaris (dog) : TYR (tyrosinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyr (tyrosinase)
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Allele / Splice: Tyrem1Kyo   TyrsiaKyo  
Genetic Models: KFRS2/Kyo DA-Tyrem1Kyo KFRS2/Kyo-/+
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi   KFRS2/Kyo   KFRS2/Kyo-/+   DA-Tyrem1Kyo   F344-TyrCKitH/Kyo   F344-AsipATyrCKitH/Kyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01151,012,598 - 151,106,802 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01157,322,968 - 157,416,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,641,257 - 143,746,315 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1139,445,261 - 139,532,999 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
 
More on Tyr
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1589755
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE