Annotation (Toggle Detail/Summary View) Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Nicotine | CTD | PMID:14570768 | 17beta-estradiol | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Estradiol | CTD | PMID:15472229 PMID:15117964 | 17beta-estradiol | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Estradiol | CTD | PMID:15117964 PMID:15472229 | 17beta-estradiol | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Estradiol analog | CTD | PMID:15472229 | 17beta-estradiol | decreases expression | ISO | RGD:1352957 | 6480464 | Estradiol results in decreased expression of UGT1A3 mRNA | CTD | PMID:16474171 | 1H-indene | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of indene | CTD | PMID:15843492 | 2,3,7,8-tetrachlorodibenzodioxine | increases activity | ISO | RGD:1352957 | 6480464 | Tetrachlorodibenzodioxin results in increased activity of UGT1A3 protein | CTD | PMID:16155002 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of UGT1A2 mRNA | CTD | PMID:20558275 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1558284 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of UGT1A2 mRNA | CTD | PMID:17949056 PMID:16611356 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1558284 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of UGT1A2 mRNA | CTD | PMID:16611356 PMID:17949056 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1352957 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of UGT1A3 mRNA | CTD | PMID:16155002 | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of UGT1A2 mRNA | CTD | PMID:21346803 | 2-hydroxy-17beta-estradiol | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of 2-hydroxyestradiol | CTD | PMID:15117964 | 2-hydroxyestrone | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of 2-hydroxyestrone | CTD | PMID:15117964 | 2-methoxy-17beta-estradiol | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of 2-methoxyestradiol | CTD | PMID:15117964 | 3-methylcholanthrene | increases expression | ISO | RGD:1352957 | 6480464 | Methylcholanthrene results in increased expression of UGT1A2 mRNA; more ... | CTD | PMID:19118567 | 3-phenylpropionic acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of 3-phenylpropionic acid | CTD | PMID:15117964 | 4-methylumbelliferone | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Hymecromone | CTD | PMID:15802387 | 4-nitrophenol | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of 4-nitrophenol | CTD | PMID:15802387 | 9-cis-retinoic acid | increases expression | EXP | | 6480464 | alitretinoin results in increased expression of UGT1A2 mRNA | CTD | PMID:14620509 | acetylsalicylic acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Aspirin | CTD | PMID:15117964 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of UGT1A3 mRNA; more ... | CTD | PMID:16483693 | anthracene-1,8,9-triol | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Anthralin | CTD | PMID:15117964 | arachidonic acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Arachidonic Acid | CTD | PMID:15231852 | Aroclor 1254 | increases expression | ISO | RGD:1352957 | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of UGT1A3 mRNA | CTD | PMID:17851650 | benzo[a]pyrene | increases expression | ISO | RGD:1558284 | 6480464 | Benzo(a)pyrene results in increased expression of UGT1A2 mRNA | CTD | PMID:20713471 PMID:20127859 | benzo[a]pyrene | increases expression | ISO | RGD:1558284 | 6480464 | Benzo(a)pyrene results in increased expression of UGT1A2 mRNA | CTD | PMID:20127859 PMID:20713471 | bilirubin | decreases activity | ISO | RGD:1352957 | 6480464 | Bilirubin results in decreased activity of UGT1A3 protein | CTD | PMID:15334623 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:1558284 | 6480464 | Diethylhexyl Phthalate results in decreased expression of UGT1A2 mRNA | CTD | PMID:19245819 | bisphenol A | decreases expression | ISO | RGD:1352957 | 6480464 | bisphenol A results in decreased expression of UGT1A3 mRNA | CTD | PMID:16474171 | capric acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of decanoic acid | CTD | PMID:16051554 | cefaloridine | increases expression | EXP | | 6480464 | Cephaloridine results in increased expression of UGT1A2 mRNA | CTD | PMID:18500788 | chenodeoxycholic acid | multiple interactions | ISO | RGD:1352957 | 6480464 | UGT1A3 protein affects the reaction [Chenodeoxycholic Acid affects the activity of FXR protein]; more ... | CTD | PMID:17058234 | chenodeoxycholic acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Chenodeoxycholic Acid | CTD | PMID:17058234 | chlorogenic acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Chlorogenic Acid | CTD | PMID:15117964 | cinnamic acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of cinnamic acid | CTD | PMID:15117964 | cis-caffeic acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of caffeic acid | CTD | PMID:15117964 | cisplatin | affects response to substance | ISO | RGD:1352957 | 6480464 | UGT1A3 protein affects the susceptibility to Cisplatin | CTD | PMID:16217747 | clofibric acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Clofibric Acid | CTD | PMID:15117964 | dexamethasone | affects expression | EXP | | 6480464 | Dexamethasone affects the expression of UGT1A2 mRNA | CTD | PMID:15102944 | diazoxide | increases expression | ISO | RGD:1558284 | 6480464 | Isoproterenol results in increased expression of UGT1A2 mRNA | CTD | PMID:20003209 | diclofenac | decreases activity | ISO | RGD:1352957 | 6480464 | Diclofenac results in decreased activity of UGT1A3 protein | CTD | PMID:15334623 | diclofenac | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Diclofenac | CTD | PMID:15117964 PMID:15843492 | diclofenac | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Diclofenac | CTD | PMID:15843492 PMID:15117964 | diethylstilbestrol | multiple interactions | ISO | RGD:1352957 | 6480464 | Phenylbutazone inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Diethylstilbestrol] | CTD | PMID:23126256 | diethylstilbestrol | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Diethylstilbestrol | CTD | PMID:23126256 | diflunisal | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Diflunisal | CTD | PMID:15117964 | estriol | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Estriol; more ... | CTD | PMID:15117964 | estrone | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Estrone analog | CTD | PMID:15472229 | estrone | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Estrone | CTD | PMID:15472229 PMID:15117964 | estrone | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Estrone | CTD | PMID:15117964 PMID:15472229 | etodolac | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Etodolac | CTD | PMID:15535975 | etoposide | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Etoposide | CTD | PMID:17151191 | ezetimibe | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of ezetimibe | CTD | PMID:14977865 | farnesol | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Farnesol | CTD | PMID:15320866 | fenofibrate | increases expression | ISO | RGD:1352957 | 6480464 | Fenofibrate results in increased expression of UGT1A3 mRNA | CTD | PMID:17058234 | fenoprofen | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Fenoprofen | CTD | PMID:15117964 | ferulic acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of ferulic acid | CTD | PMID:15117964 | flurbiprofen | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Flurbiprofen | CTD | PMID:15117964 PMID:15843492 | flurbiprofen | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Flurbiprofen | CTD | PMID:15843492 PMID:15117964 | furosemide | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Furosemide | CTD | PMID:15117964 | genistein | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Genistein | CTD | PMID:15988124 | genistein | decreases expression | ISO | RGD:1352957 | 6480464 | Genistein results in decreased expression of UGT1A3 mRNA | CTD | PMID:16474171 | glutathione | increases expression | EXP | | 6480464 | Glutathione deficiency results in increased expression of UGT1A3 mRNA; more ... | CTD | PMID:15345336 | hydratropic acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of hydratropic acid | CTD | PMID:15117964 | ibuprofen | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Ibuprofen | CTD | PMID:15117964 PMID:15843492 | ibuprofen | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Ibuprofen | CTD | PMID:15843492 PMID:15117964 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of UGT1A3 mRNA; more ... | CTD | PMID:21396975 | indole-3-methanol | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of UGT1A2 mRNA; more ... | CTD | PMID:22129741 | indomethacin | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Indomethacin | CTD | PMID:15117964 PMID:15843492 | indomethacin | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Indomethacin | CTD | PMID:15843492 PMID:15117964 | isoprenaline | increases expression | ISO | RGD:1558284 | 6480464 | Isoproterenol results in increased expression of UGT1A2 mRNA | CTD | PMID:20003209 | isovaleric acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of isovaleric acid analog | CTD | PMID:15117964 | kaempferol | affects glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 mutant form affects the glucuronidation of kaempferol | CTD | PMID:16738032 | kaempferol | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of kaempferol | CTD | PMID:16738032 | ketoprofen | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Ketoprofen | CTD | PMID:15843492 PMID:15535975 | ketoprofen | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Ketoprofen | CTD | PMID:15535975 PMID:15843492 | kojic acid | multiple interactions | ISO | RGD:1558284 | 6480464 | [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of UGT1A2 mRNA | CTD | PMID:17917374 | L-ascorbic acid | multiple interactions | ISO | RGD:1558284 | 6480464 | [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of UGT1A2 mRNA | CTD | PMID:17917374 | lamotrigine | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of lamotrigine | CTD | PMID:17151188 | lauric acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of lauric acid | CTD | PMID:16051554 | luteolin | affects glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 mutant form affects the glucuronidation of Luteolin | CTD | PMID:16738032 | luteolin | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Luteolin | CTD | PMID:16738032 | methoxychlor | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Methoxychlor metabolite | CTD | PMID:15205390 | methyl salicylate | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of methyl salicylate | CTD | PMID:15117964 | morphine | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Morphine | CTD | PMID:12920162 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:1558284 | 6480464 | [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of UGT1A2 mRNA | CTD | PMID:17917374 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of UGT1A2 mRNA; more ... | CTD | PMID:22129741 | naproxen | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Naproxen | CTD | PMID:15535975 PMID:15843492 | naproxen | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Naproxen | CTD | PMID:15843492 PMID:15535975 | ofloxacin | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Ofloxacin | CTD | PMID:15769885 | omeprazole | increases expression | ISO | RGD:1352957 | 6480464 | Omeprazole results in increased expression of UGT1A3 mRNA; more ... | CTD | PMID:19118567 | paracetamol | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Acetaminophen | CTD | PMID:15117964 | perfluorooctane-1-sulfonic acid | affects expression | ISO | RGD:1558284 | 6480464 | perfluorooctane sulfonic acid affects the expression of UGT1A2 mRNA | CTD | PMID:19429403 | perfluorooctanoic acid | affects expression | ISO | RGD:1558284 | 6480464 | perfluorooctanoic acid affects the expression of UGT1A2 mRNA | CTD | PMID:19429403 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of UGT1A3 mRNA | CTD | PMID:19631232 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of UGT1A2 mRNA | CTD | PMID:16940010 | phenobarbital | multiple interactions | EXP | | 6480464 | GW 7647 promotes the reaction [Phenobarbital results in increased expression of UGT1A3 mRNA]; more ... | CTD | PMID:19631232 | phenylbutazone | multiple interactions | ISO | RGD:1352957 | 6480464 | Phenylbutazone inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Diethylstilbestrol] | CTD | PMID:23126256 | pirinixic acid | increases expression | ISO | RGD:1352957 | 6480464 | pirinixic acid results in increased expression of UGT1A3 mRNA | CTD | PMID:17058234 PMID:17151188 | pirinixic acid | increases expression | ISO | RGD:1352957 | 6480464 | pirinixic acid results in increased expression of UGT1A3 mRNA | CTD | PMID:17151188 PMID:17058234 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of UGT1A3 mRNA | CTD | PMID:19631232 | pirinixic acid | multiple interactions | EXP | | 6480464 | pirinixic acid promotes the reaction [Phenobarbital results in increased expression of UGT1A3 mRNA] | CTD | PMID:19631232 | ponasterone A | increases expression | ISO | RGD:1352957 | 6480464 | ponasterone A results in increased expression of UGT1A3 protein | CTD | PMID:17058234 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of UGT1A2 mRNA | CTD | PMID:19162173 | pregnenolone 16alpha-carbonitrile | increases expression | ISO | RGD:1352957 | 6480464 | Pregnenolone Carbonitrile results in increased expression of UGT1A3 mRNA | CTD | PMID:16155002 | quercetin | affects glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 mutant form affects the glucuronidation of Quercetin | CTD | PMID:16738032 | quercetin | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Quercetin | CTD | PMID:16738032 | salicylic acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Salicylic Acid | CTD | PMID:15117964 | scopoletin | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Scopoletin | CTD | PMID:15802387 | sevoflurane | affects expression | EXP | | 6480464 | sevoflurane affects the expression of UGT1A2 mRNA; more ... | CTD | PMID:15967596 | spironolactone | increases expression | ISO | RGD:1558284 | 6480464 | Spironolactone results in increased expression of UGT1A2 mRNA | CTD | PMID:19144771 | sulindac | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Sulindac | CTD | PMID:15843492 | tetrachloromethane | affects expression | ISO | RGD:1558284 | 6480464 | Carbon Tetrachloride affects the expression of UGT1A2 mRNA | CTD | PMID:17484886 | triclocarban | multiple interactions | ISO | RGD:1352957 | 6480464 | NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A3 mRNA] | CTD | PMID:22761658 | triclocarban | increases expression | ISO | RGD:1352957 | 6480464 | triclocarban results in increased expression of UGT1A3 mRNA | CTD | PMID:22761658 | vanillic acid | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of Vanillic Acid | CTD | PMID:15117964 | vanillin | increases glucuronidation | ISO | RGD:1352957 | 6480464 | UGT1A3 protein results in increased glucuronidation of vanillin | CTD | PMID:15117964 | zinc atom | increases expression | ISO | RGD:1352957 | 6480464 | Zinc deficiency results in increased expression of UGT1A3 mRNA | CTD | PMID:18356318 | zinc(0) | increases expression | ISO | RGD:1352957 | 6480464 | Zinc deficiency results in increased expression of UGT1A3 mRNA | CTD | PMID:18356318 | | |||||||||||||||||||||||||||||||
Gene Ontology AnnotationsBiological Process











