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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619831
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fas
Name: Fas cell surface death receptor
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasmultiple interactionsEXP 628329RGDfenofibrate co-treated with fructose diet increases expression of Fas mRNA in liver 
Fasdecreases expressionEXP 6480464CTDFenofibrate results in decreased expression of FAS mRNAPMID:25596134
Fasdecreases expressionISOFAS (Homo sapiens)6480464CTDFenofibrate results in decreased expression of FAS mRNAPMID:25596134
Fasmultiple interactionsISOFas (Mus musculus)6480464CTDFenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FAS mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FAS mRNA]]PMID:19593819
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