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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3387
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkaa1
Name: protein kinase AMP-activated catalytic subunit alpha 1
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkaa1decreases response to substanceISOPRKAA1 (Homo sapiens)6480464CTDPRKAA1 gene mutant form results in decreased susceptibility to FenofibratePMID:25545733
Prkaa1multiple interactionsISOPRKAA1 (Homo sapiens)6480464CTDPRKAA1 protein affects the reaction [Fenofibrate results in decreased susceptibility to ALB protein modified form]; PRKAA1 protein affects the reaction [Fenofibrate results in increased abundance of Nitric Oxide]; PRKAA1 protein affects the reaction [Fenofibrate results in increased activity of NOS3 protein]PMID:20580385
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