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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | multiple interactions | ISO | RGD:1344945 | 6480464 | Nicotine results in increased phosphorylation of and results in increased activity of LCK protein; more ... | CTD | PMID:17709503 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:10861 | 6480464 | Ethinyl Estradiol affects the expression of LCK mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:10861 | 6480464 | Ethinyl Estradiol results in increased expression of LCK mRNA | CTD | PMID:17942748 | 17beta-estradiol | multiple interactions | ISO | RGD:1344945 | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of LCK mRNA | CTD | PMID:17404688 | 17beta-estradiol | decreases expression | ISO | RGD:1344945 | 6480464 | Estradiol results in decreased expression of LCK mRNA | CTD | PMID:23373633 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1344945 | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of LCK mRNA] | CTD | PMID:11007951 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:10861 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LCK mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1344945 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LCK mRNA | CTD | PMID:11007951 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:1344945 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of LCK mRNA | CTD | PMID:12419474 | acetohydrazide | decreases expression | ISO | RGD:10861 | 6480464 | acetylhydrazine results in decreased expression of LCK mRNA | CTD | PMID:15282401 | acetylsalicylic acid | decreases expression | ISO | RGD:1344945 | 6480464 | Aspirin results in decreased expression of LCK mRNA | CTD | PMID:15928584 | afimoxifene | decreases expression | ISO | RGD:1344945 | 6480464 | 4-hydroxytamoxifen results in decreased expression of LCK mRNA | CTD | PMID:23373633 | all-trans-retinoic acid | increases expression | ISO | RGD:1344945 | 6480464 | Tretinoin results in increased expression of LCK mRNA | CTD | PMID:15498508 | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of LCK mRNA | CTD | PMID:20488242 | benzo[a]pyrene | decreases expression | ISO | RGD:10861 | 6480464 | Benzo(a)pyrene results in decreased expression of LCK mRNA | CTD | PMID:21569818 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of LCK mRNA | CTD | PMID:18180321 | chloroprene | decreases expression | ISO | RGD:10861 | 6480464 | Chloroprene results in decreased expression of LCK mRNA | CTD | PMID:23125180 | chromium(6+) | multiple interactions | ISO | RGD:1344945 | 6480464 | LCK protein affects the reaction [chromium hexavalent ion results in increased expression of IL6 mRNA]; more ... | CTD | PMID:17078813 | crocidolite asbestos | affects expression | ISO | RGD:1344945 | 6480464 | Asbestos, Crocidolite affects the expression of LCK mRNA | CTD | PMID:17331233 | cycloheximide | multiple interactions | ISO | RGD:1344945 | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of LCK mRNA] | CTD | PMID:11007951 | cyclophosphamide | decreases expression | ISO | RGD:10861 | 6480464 | Cyclophosphamide results in decreased expression of LCK mRNA | CTD | PMID:21041162 | dasatinib (anhydrous) | decreases activity | ISO | RGD:1344945 | 6480464 | dasatinib results in decreased activity of LCK protein | CTD | PMID:18550857 | dexamethasone | decreases expression | ISO | RGD:10861 | 6480464 | Dexamethasone results in decreased expression of LCK mRNA | CTD | PMID:21041162 | diethylstilbestrol | decreases expression | ISO | RGD:10861 | 6480464 | Diethylstilbestrol results in decreased expression of LCK mRNA | CTD | PMID:21041162 | hydrazine | decreases expression | ISO | RGD:10861 | 6480464 | hydrazine results in decreased expression of LCK mRNA | CTD | PMID:15282401 | imatinib | decreases phosphorylation | ISO | RGD:1344945 | 6480464 | imatinib results in decreased phosphorylation of LCK protein | CTD | PMID:15100154 | isotretinoin | increases expression | ISO | RGD:1344945 | 6480464 | Isotretinoin results in increased expression of LCK mRNA | CTD | PMID:20436886 | lead diacetate | increases expression | ISO | RGD:10861 | 6480464 | lead acetate results in increased expression of LCK mRNA | CTD | PMID:21829687 | methotrexate | affects response to substance | ISO | RGD:1344945 | 6480464 | LCK protein affects the susceptibility to Methotrexate | CTD | PMID:16217747 | N-methyl-4-phenylpyridinium | increases expression | ISO | RGD:10861 | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of LCK mRNA | CTD | PMID:22776087 | pirinixic acid | decreases expression | ISO | RGD:10861 | 6480464 | pirinixic acid results in decreased expression of LCK mRNA | CTD | PMID:17426115 PMID:20813756 | pirinixic acid | decreases expression | ISO | RGD:10861 | 6480464 | pirinixic acid results in decreased expression of LCK mRNA | CTD | PMID:20813756 PMID:17426115 | potassium dichromate | multiple interactions | ISO | RGD:1344945 | 6480464 | LCK protein affects the reaction [Potassium Dichromate results in increased expression of IL6 mRNA]; more ... | CTD | PMID:17078813 | progesterone | multiple interactions | ISO | RGD:1344945 | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of LCK mRNA | CTD | PMID:17404688 | succimer | multiple interactions | ISO | RGD:10861 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of LCK mRNA | CTD | PMID:21641980 | tamibarotene | increases expression | ISO | RGD:1344945 | 6480464 | Am 80 results in increased expression of LCK mRNA; more ... | CTD | PMID:15498508 | tamoxifen | affects expression | ISO | RGD:10861 | 6480464 | Tamoxifen affects the expression of LCK mRNA | CTD | PMID:17555576 | trichloroethene | increases phosphorylation | ISO | RGD:10861 | 6480464 | Trichloroethylene results in increased phosphorylation of LCK protein | CTD | PMID:22467029 | valproic acid | decreases expression | ISO | RGD:10861 | 6480464 | Valproic Acid results in decreased expression of LCK mRNA | CTD | PMID:21427059 | zinc atom | increases expression | ISO | RGD:10861 | 6480464 | Zinc deficiency results in increased expression of LCK mRNA; more ... | CTD | PMID:11739864 | zinc(0) | increases expression | ISO | RGD:10861 | 6480464 | Zinc deficiency results in increased expression of LCK mRNA; more ... | CTD | PMID:11739864 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | HTLV-I infection |
| Natural killer cell mediated cytotoxicity | |
| NF-kappa B signaling pathway | |
| Osteoclast differentiation | |
| Primary immunodeficiency | |
| T cell receptor signaling pathway | |
| Pathway Interaction Database | Alpha-synuclein signaling (PID:200219) |
| amb2 Integrin signaling (PID:200127) | |
| Atypical NF-kappaB pathway (PID:200021) | |
| Class I PI3K signaling events (PID:200116) | |
| CXCR4-mediated signaling events (PID:200099) | |
| EPHA forward signaling (PID:200142) | |
| Ephrin B reverse signaling (PID:200204) | |
| Glypican 1 network (PID:200026) | |
| IL12-mediated signaling events (PID:200045) | |
| IL2 signaling events mediated by PI3K (PID:200118) | |
| IL2 signaling events mediated by STAT5 (PID:200184) | |
| IL2-mediated signaling events (PID:200098) | |
| PDGFR-beta signaling pathway (PID:200149) | |
| Regulation of p38-alpha and p38-beta (PID:200066) | |
| SHP2 signaling (PID:200083) | |
| Signaling events mediated by PTP1B (PID:200042) | |
| TCR signaling in naïve CD4+ T cells (PID:200027) | |
| TCR signaling in naïve CD8+ T cells (PID:200075) | |
| Thromboxane A2 receptor signaling (PID:200082) | |
References - curated| 1. |
Fukushima A, etal., Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4366-74. |
| 2. |
Garcia-Welsh A, etal., J Leukoc Biol. 1994 Oct;56(4):528-32. |
| 3. |
Garnett D, etal., Eur J Immunol. 1993 Oct;23(10):2540-4. |
| 4. |
Hardwick JS and Sefton BM, J Biol Chem. 1997 Oct 10;272(41):25429-32. |
| 5. |
Hosea HJ, etal., Clin Dev Immunol. 2005 Mar;12(1):75-84. |
| 6. |
Hosea HJ, etal., J Nutr. 2003 Dec;133(12):4239-42. |
| 7. |
MGD data from the GO Consortium |
| 8. |
Nunes RJ, etal., J Immunol. 2008 Jan 15;180(2):988-97. |
| 9. |
Pascale MC, etal., FEBS Lett. 2000 Sep 1;480(2-3):226-30. |
| 10. |
Phillippe M, etal., Reprod Sci. 2009 Mar;16(3):265-73. |
| 11. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 12. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 13. |
Poole AW, etal., Trends Pharmacol Sci. 2004 Oct;25(10):528-35. |
| 14. |
RGD automated data pipeline |
| 15. |
RGD automated import pipeline for gene-chemical interactions |
| 16. |
Savignac M, etal., Eur J Immunol. 2001 Aug;31(8):2266-76. |
| 17. |
Stenberg PE, etal., Blood. 1997 Apr 1;89(7):2384-93. |
| 18. |
Wang ZH, etal., Chin Med J (Engl). 2007 Aug 5;120(15):1319-25. |
| 19. |
Yadav A, etal., Virology. 2006 Sep 30;353(2):357-65. Epub 2006 Jul 10. |
| 20. |
Yu XZ, etal., J Immunol 2004 Feb 1;172(3):1437-43. |
References - uncuratedRGD Disease Portals| Lck has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Lck (Rattus norvegicus) |
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| LCK (Homo sapiens) |
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| Lck (Mus musculus) |
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Position Markers| D5Wox15 |
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| RH132104 |
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| PMC166405P2 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001100709 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06040041 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01039889 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01039890 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC099218 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC160881 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473968 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Z15029 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001100709 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001094179 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001094179 | (Get FASTA) |
| GenBank Protein | AAH99218 | (Get FASTA) |
| AAI60881 | (Get FASTA) | |
| CAA78748 | (Get FASTA) | |
| EDL80546 | (Get FASTA) | |
| Q01621 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000009705 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000012936 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000012936 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 313050 | ENTREZGENE |
| Gene3D-CATH | SH2 | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000009705 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 3911 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7381544 | IMAGE-MGC_LOAD |
| IMAGE:7384919 | IMAGE-MGC_LOAD | |
| InterPro | Kinase-like_dom | UniProtKB/Swiss-Prot |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser-Thr/Tyr-Pkinase | UniProtKB/Swiss-Prot | |
| SH2 | UniProtKB/Swiss-Prot | |
| SH3_domain | UniProtKB/Swiss-Prot | |
| Tyr_Pkinase_cat_dom | UniProtKB/Swiss-Prot | |
| Tyr_prot_kinase_AS | UniProtKB/Swiss-Prot | |
| IPI | IPI00205116 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:313050 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:116394 | IMAGE-MGC_LOAD |
| MGC:188286 | IMAGE-MGC_LOAD | |
| Pfam | Pkinase_Tyr | UniProtKB/Swiss-Prot |
| SH2 | UniProtKB/Swiss-Prot | |
| SH3_1 | UniProtKB/Swiss-Prot | |
| PharmGKB | LCK | RGD |
| PRINTS | SH2DOMAIN | UniProtKB/Swiss-Prot |
| SH3DOMAIN | UniProtKB/Swiss-Prot | |
| TYRKINASE | UniProtKB/Swiss-Prot | |
| PROSITE | PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_TYR | UniProtKB/Swiss-Prot | |
| SH2 | UniProtKB/Swiss-Prot | |
| SH3 | UniProtKB/Swiss-Prot | |
| SMART | SH2 | UniProtKB/Swiss-Prot |
| SH3 | UniProtKB/Swiss-Prot | |
| TyrKc | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| SH3 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.22791 | ENTREZGENE |
| UniProt | LCK_RAT | UniProtKB/Swiss-Prot |
| Q4FZR6_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-11-17 | Lck | lymphocyte-specific protein tyrosine kinase | Lck | lymphocyte protein tyrosine kinase | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2007-03-14 | Lck | lymphocyte protein tyrosine kinase | Lck_predicted | lymphocyte protein tyrosine kinase (predicted) | Symbol and Name updated | 10779 | APPROVED |
| 2007-03-05 | Lck_predicted | lymphocyte protein tyrosine kinase (predicted) | Lck_mapped | lymphocyte protein tyrosine kinase (mapped) | Symbol and Name updated | 10779 | APPROVED |
| 2007-03-05 | Lck_mapped | lymphocyte protein tyrosine kinase (mapped) | Lck_retired | Data Merged | 9333 | APPROVED | |
| 2006-11-19 | Lck | lymphocyte protein tyrosine kinase (mapped) | Symbol and Name status set to provisional | 1724 | PROVISIONAL | ||
| 2005-11-17 | Lck_mapped | lymphocyte protein tyrosine kinase (mapped) | Symbol and Name updated | 14094 | APPROVED | ||
| 2002-06-10 | Lck | Lymphocyte-specific protein tyrosine kinase | Symbol and Name status set to approved | 1490 | APPROVED |
| More on Lck | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2994 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.