Gene: Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3) Rattus norvegicus
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Description: ENCODES a protein that exhibits eukaryotic translation initiation factor 2alpha kinase activity; Hsp90 protein binding; protein serine/threonine kinase activity; INVOLVED IN negative regulation of translation in response to stress; protein autophosphorylation; protein phosphorylation; PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Alzheimer disease pathway; Endoplasmic Reticulum-associated degradation pathway; ASSOCIATED WITH Reperfusion Injury; Diabetes Mellitus, Type 1 (ortholog); Wolcott-Rallison Syndrome (ortholog); FOUND IN perinuclear region of cytoplasm; cytoplasm (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 1,4-dithiothreitol; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: eukaryotic translation initiation factor 2-alpha kinase 3; pancreatic eIF2-alpha kinase; PEK; PRKR-like endoplasmic reticulum kinase
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0498,648,513 - 98,709,695 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.04163,428,182 - 163,488,914 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.44104,016,940 - 104,078,261 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14104,261,420 - 104,322,741 (+)NCBI
Celera491,981,676 - 92,042,995 (+)NCBI
Cytogenetic Map4q32NCBImapview
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Eif2ak3
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 70884
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2016-09-13
Status: ACTIVE