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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1345586 | 6480464 | [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of F7 protein | CTD | PMID:14561536 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1345586 | 6480464 | [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein | CTD | PMID:12616980 more ... | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1345586 | 6480464 | F7 gene polymorphism affects the reaction [[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein] | CTD | PMID:12616980 PMID:12616980 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1345586 | 6480464 | [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein | CTD | PMID:12618251 more ... | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1345586 | 6480464 | [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein | CTD | PMID:12616980 more ... | 17alpha-ethynylestradiol | affects expression | ISO | RGD:731512 | 6480464 | Ethinyl Estradiol affects the expression of F7 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1345586 | 6480464 | F7 gene polymorphism affects the reaction [[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein] | CTD | PMID:12616980 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1345586 | 6480464 | [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of F7 protein | CTD | PMID:15157790 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1345586 | 6480464 | Ethinyl Estradiol results in increased expression of F7 protein | CTD | PMID:8950781 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1345586 | 6480464 | [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of F7 protein; more ... | CTD | PMID:12618251 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1345586 | 6480464 | [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein | CTD | PMID:8950781 more ... | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1345586 | 6480464 | [Ethinyl Estradiol co-treated with dienogest] results in increased expression of F7 protein; more ... | CTD | PMID:15288212 | 17beta-estradiol | multiple interactions | ISO | RGD:1345586 | 6480464 | [Estradiol co-treated with norethindrone acetate] results in decreased expression of F7 protein | CTD | PMID:17393018 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:731512 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of F7 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases expression | ISO | RGD:731512 | 6480464 | Aflatoxin B1 results in decreased expression of F7 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases expression | ISO | RGD:1345586 | 6480464 | Aflatoxin B1 results in decreased expression of F7 mRNA | CTD | PMID:22100608 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of F7 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | ISO | RGD:731512 | 6480464 | Benzo(a)pyrene results in decreased expression of F7 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | increases expression | ISO | RGD:731512 | 6480464 | Benzo(a)pyrene results in increased expression of F7 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | RGD:1345586 | 6480464 | Benzo(a)pyrene results in decreased expression of F7 mRNA | CTD | PMID:22316170 | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of F7 promoter | CTD | PMID:22457795 | clofibrate | multiple interactions | ISO | RGD:731512 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of F7 mRNA; more ... | CTD | PMID:17585979 | clofibrate | decreases expression | ISO | RGD:731512 | 6480464 | Clofibrate results in decreased expression of F7 mRNA | CTD | PMID:17585979 | dienogest | multiple interactions | ISO | RGD:1345586 | 6480464 | [Ethinyl Estradiol co-treated with dienogest] results in increased expression of F7 protein | CTD | PMID:15288212 | doxorubicin | multiple interactions | ISO | RGD:1345586 | 6480464 | [[F3 protein co-treated with F7 protein] results in increased expression of BCL2 protein] which results in decreased susceptibility to Doxorubicin | CTD | PMID:18325115 | fenofibrate | multiple interactions | ISO | RGD:1345586 | 6480464 | Fenofibrate promotes the reaction [Warfarin results in decreased expression of F7 protein] | CTD | PMID:9681093 | fumonisin B1 | decreases expression | ISO | RGD:731512 | 6480464 | fumonisin B1 results in decreased expression of F7 mRNA | CTD | PMID:16221962 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of F7 gene | CTD | PMID:22079235 | geneticin | multiple interactions | ISO | RGD:1345586 | 6480464 | antibiotic G 418 results in increased expression of and results in increased activity of F7 protein | CTD | PMID:16706976 | hydrogen peroxide | affects expression | ISO | RGD:1345586 | 6480464 | Hydrogen Peroxide affects the expression of F7 mRNA | CTD | PMID:20044591 | levonorgestrel | multiple interactions | ISO | RGD:1345586 | 6480464 | [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of F7 protein | CTD | PMID:12618251 | levonorgestrel | multiple interactions | ISO | RGD:1345586 | 6480464 | [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of F7 protein | CTD | PMID:15157790 | medroxyprogesterone acetate | decreases expression | ISO | RGD:1345586 | 6480464 | Medroxyprogesterone Acetate results in decreased expression of F7 | CTD | PMID:1828463 | menaquinone | multiple interactions | EXP | | 6480464 | [Phenobarbital co-treated with Vitamin K 2] results in increased activity of F7 protein | CTD | PMID:19952496 | mestranol | increases expression | ISO | RGD:1345586 | 6480464 | Mestranol results in increased expression of F7 protein | CTD | PMID:614942 | morphine | increases expression | ISO | RGD:1345586 | 6480464 | Morphine results in increased expression of F7 protein | CTD | PMID:18980684 | norethisterone | multiple interactions | ISO | RGD:1345586 | 6480464 | [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of F7 protein | CTD | PMID:14561536 | norgestimate | multiple interactions | ISO | RGD:1345586 | 6480464 | [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of F7 protein | CTD | PMID:12618251 | ozone | multiple interactions | ISO | RGD:731512 | 6480464 | TTPA protein affects the reaction [Ozone results in increased expression of F7 mRNA] | CTD | PMID:19555225 | paracetamol | multiple interactions | ISO | RGD:731512 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of F7 mRNA; more ... | CTD | PMID:17585979 | paracetamol | affects expression | ISO | RGD:731512 | 6480464 | Acetaminophen affects the expression of F7 mRNA | CTD | PMID:17562736 | perfluorooctane-1-sulfonic acid | affects expression | ISO | RGD:731512 | 6480464 | perfluorooctane sulfonic acid affects the expression of F7 mRNA | CTD | PMID:19429403 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | RGD:731512 | 6480464 | perfluorooctane sulfonic acid results in decreased expression of F7 mRNA | CTD | PMID:20936131 | perfluorooctanoic acid | decreases expression | ISO | RGD:731512 | 6480464 | perfluorooctanoic acid results in decreased expression of F7 mRNA | CTD | PMID:18467677 | perfluorooctanoic acid | decreases expression | ISO | RGD:731512 | 6480464 | perfluorooctanoic acid results in decreased expression of F7 mRNA | CTD | PMID:18467677 PMID:20936131 | perfluorooctanoic acid | multiple interactions | ISO | RGD:731512 | 6480464 | PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of F7 mRNA] | CTD | PMID:18467677 | perfluorooctanoic acid | affects expression | ISO | RGD:731512 | 6480464 | perfluorooctanoic acid affects the expression of F7 mRNA | CTD | PMID:19429403 | phenobarbital | decreases activity | EXP | | 6480464 | Phenobarbital results in decreased activity of F7 protein | CTD | PMID:19952496 | phenobarbital | multiple interactions | EXP | | 6480464 | [Phenobarbital co-treated with Vitamin K 2] results in increased activity of F7 protein | CTD | PMID:19952496 | pirinixic acid | multiple interactions | ISO | RGD:731512 | 6480464 | [pirinixic acid co-treated with PPARA] results in decreased expression of F7 mRNA | CTD | PMID:20813756 | pirinixic acid | decreases expression | ISO | RGD:731512 | 6480464 | pirinixic acid results in decreased expression of F7 mRNA | CTD | PMID:16221962 more ... | pirinixic acid | decreases expression | ISO | RGD:731512 | 6480464 | pirinixic acid results in decreased expression of F7 mRNA | CTD | PMID:16221962 more ... | pirinixic acid | decreases expression | ISO | RGD:731512 | 6480464 | pirinixic acid results in decreased expression of F7 mRNA | CTD | PMID:18467677 more ... | pirinixic acid | decreases expression | ISO | RGD:731512 | 6480464 | pirinixic acid results in decreased expression of F7 mRNA | CTD | PMID:20059764 more ... | pirinixic acid | decreases expression | ISO | RGD:731512 | 6480464 | pirinixic acid results in decreased expression of F7 mRNA | CTD | PMID:20813756 more ... | pirinixic acid | multiple interactions | ISO | RGD:731512 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of F7 mRNA] | CTD | PMID:20059764 PMID:18467677 | pirinixic acid | decreases expression | ISO | RGD:731512 | 6480464 | pirinixic acid results in decreased expression of F7 mRNA | CTD | PMID:20813756 more ... | pirinixic acid | multiple interactions | ISO | RGD:731512 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of F7 mRNA] | CTD | PMID:18467677 PMID:20059764 | pirinixic acid | decreases expression | ISO | RGD:731512 | 6480464 | pirinixic acid results in decreased expression of F7 mRNA | CTD | PMID:18467677 more ... | quercetin | decreases expression | ISO | RGD:1345586 | 6480464 | Quercetin results in decreased expression of F7 mRNA | CTD | PMID:21632981 | riddelliine | increases expression | EXP | | 6480464 | riddelliine results in increased expression of F7 mRNA | CTD | PMID:18047727 | tamoxifen | affects expression | ISO | RGD:731512 | 6480464 | Tamoxifen affects the expression of F7 mRNA | CTD | PMID:17555576 | trimellitic anhydride | increases expression | ISO | RGD:731512 | 6480464 | trimellitic anhydride results in increased expression of F7 mRNA | CTD | PMID:19042947 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Complement and coagulation cascades |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Complement and coagulation cascades |
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Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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RGD automated data pipeline |
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RGD automated import pipeline for gene-chemical interactions |
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RGD comprehensive gene curation |
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References - uncurated| PubMed | 19062044 |
RGD Disease Portals| F7 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| F7 (Rattus norvegicus) |
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| F7 (Homo sapiens) |
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| F7 (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_152846 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06089464 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01089110 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01089111 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF532184 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473970 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_152846 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_690059 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_690059 | (Get FASTA) |
| GenBank Protein | AAM95967 | (Get FASTA) |
| EDM08867 | (Get FASTA) | |
| EDM08868 | (Get FASTA) | |
| EDM08869 | (Get FASTA) | |
| Q8K3U6 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000032737 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000038466 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000037806 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 260320 | ENTREZGENE |
| Gene3D-CATH | Coagulation_factor_Gla | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 7710 | ENTREZGENE |
| InterPro | Coagulation_fac_subgr_Gla_dom | UniProtKB/Swiss-Prot |
| EGF-like_reg_CS | UniProtKB/Swiss-Prot | |
| EGF-type_Asp/Asn_hydroxyl_site | UniProtKB/Swiss-Prot | |
| EGF_3 | UniProtKB/Swiss-Prot | |
| EGF_Ca_bd | UniProtKB/Swiss-Prot | |
| EGF_Ca_bd_CS | UniProtKB/Swiss-Prot | |
| GLA_domain | UniProtKB/Swiss-Prot | |
| Pept_S1A_FX | UniProtKB/Swiss-Prot | |
| Peptidase_S1/S6_AS | UniProtKB/Swiss-Prot | |
| Peptidase_S1_S6 | UniProtKB/Swiss-Prot | |
| Peptidase_S1A | UniProtKB/Swiss-Prot | |
| Ser/Cys_Pept_Trypsin-like | UniProtKB/Swiss-Prot | |
| IPI | IPI00202610 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:260320 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | EGF | UniProtKB/Swiss-Prot |
| Gla | UniProtKB/Swiss-Prot | |
| Trypsin | UniProtKB/Swiss-Prot | |
| PharmGKB | F7 | RGD |
| PIRSF | Factor_X | UniProtKB/Swiss-Prot |
| PRINTS | CHYMOTRYPSIN | UniProtKB/Swiss-Prot |
| GLABLOOD | UniProtKB/Swiss-Prot | |
| PROSITE | ASX_HYDROXYL | UniProtKB/Swiss-Prot |
| EGF_1 | UniProtKB/Swiss-Prot | |
| EGF_2; FALSE_NEG | UniProtKB/Swiss-Prot | |
| EGF_3 | UniProtKB/Swiss-Prot | |
| EGF_CA | UniProtKB/Swiss-Prot | |
| GLA_1 | UniProtKB/Swiss-Prot | |
| GLA_2 | UniProtKB/Swiss-Prot | |
| TRYPSIN_DOM | UniProtKB/Swiss-Prot | |
| TRYPSIN_HIS | UniProtKB/Swiss-Prot | |
| TRYPSIN_SER | UniProtKB/Swiss-Prot | |
| SMART | EGF | UniProtKB/Swiss-Prot |
| EGF_CA | UniProtKB/Swiss-Prot | |
| GLA | UniProtKB/Swiss-Prot | |
| Tryp_SPc | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Pept_Ser_Cys | UniProtKB/Swiss-Prot |
| VitK_dep_GLA | UniProtKB/Swiss-Prot | |
| UniGene | Rn.86416 | ENTREZGENE |
| UniProt | FA7_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-10-17 | F7 | coagulation factor VII (serum prothrombin conversion accelerator) | F7 | coagulation factor VII | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-01-20 | F7 | coagulation factor VII | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2003-02-27 | F7 | coagulation factor VII | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on F7 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 628678 |
| Created: | 2003-02-27 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.