Annotation (Toggle Detail/Summary View) Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1557220 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PML mRNA | CTD | PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1557220 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PML mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1557220 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PML mRNA | CTD | PMID:19933214 PMID:21889950 | 4'-epidoxorubicin | affects mutagenesis | ISO | RGD:1345145 | 6480464 | Epirubicin affects the mutagenesis of PML gene | CTD | PMID:19884644 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:1557220 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of PML mRNA | CTD | PMID:18648102 | 5-azacytidine | increases expression | ISO | RGD:1345145 | 6480464 | Azacitidine results in increased expression of PML mRNA | CTD | PMID:19194470 | aflatoxin B1 | increases expression | ISO | RGD:1557220 | 6480464 | Aflatoxin B1 results in increased expression of PML mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases expression | ISO | RGD:1345145 | 6480464 | Aflatoxin B1 results in increased expression of PML mRNA | CTD | PMID:21641981 | all-trans-retinoic acid | affects localization | ISO | RGD:1345145 | 6480464 | Tretinoin affects the localization of PML protein | CTD | PMID:9834237 | all-trans-retinoic acid | increases degradation | ISO | RGD:1345145 | 6480464 | Tretinoin results in increased degradation of PML protein mutant form | CTD | PMID:15748426 more ... | all-trans-retinoic acid | increases degradation | ISO | RGD:1345145 | 6480464 | Tretinoin results in increased degradation of PML protein mutant form | CTD | PMID:9834237 more ... | all-trans-retinoic acid | increases degradation | ISO | RGD:1345145 | 6480464 | Tretinoin results in increased degradation of PML protein mutant form | CTD | PMID:15748426 more ... | all-trans-retinoic acid | increases degradation | ISO | RGD:1345145 | 6480464 | Tretinoin results in increased degradation of PML protein mutant form | CTD | PMID:15748426 more ... | all-trans-retinoic acid | increases degradation | ISO | RGD:1345145 | 6480464 | Tretinoin results in increased degradation of PML protein mutant form | CTD | PMID:17217047 more ... | all-trans-retinoic acid | increases degradation | ISO | RGD:1345145 | 6480464 | Tretinoin results in increased degradation of PML protein mutant form | CTD | PMID:9834237 more ... | all-trans-retinoic acid | increases phosphorylation | ISO | RGD:1345145 | 6480464 | Tretinoin results in increased phosphorylation of PML protein mutant form | CTD | PMID:19029980 | all-trans-retinoic acid | decreases expression | ISO | RGD:1345145 | 6480464 | Tretinoin results in decreased expression of PML mRNA | CTD | PMID:16249480 | all-trans-retinoic acid | increases degradation | ISO | RGD:1345145 | 6480464 | Tretinoin results in increased degradation of PML protein mutant form | CTD | PMID:19029980 more ... | all-trans-retinoic acid | increases cleavage | ISO | RGD:1345145 | 6480464 | Tretinoin results in increased cleavage of PML protein mutant form | CTD | PMID:12130515 | all-trans-retinoic acid | increases expression | ISO | RGD:1345145 | 6480464 | Tretinoin results in increased expression of PML protein | CTD | PMID:12015078 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1345145 | 6480464 | Tretinoin inhibits the reaction [PML protein mutant form results in decreased expression of SPI1 mRNA]; more ... | CTD | PMID:16352814 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1345145 | 6480464 | Tretinoin inhibits the reaction [CCNH protein binds to and results in increased phosphorylation of PML protein mutant form] | CTD | PMID:16935935 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1345145 | 6480464 | [Tretinoin co-treated with Butyrates] results in increased cleavage of PML protein mutant form; more ... | CTD | PMID:12130515 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1345145 | 6480464 | [Tretinoin co-treated with arsenic trioxide] results in decreased expression of PML mRNA alternative form | CTD | PMID:19225113 | Aroclor 1254 | decreases expression | ISO | RGD:1345145 | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of PML mRNA | CTD | PMID:16934159 | arsenic atom | multiple interactions | ISO | RGD:1345145 | 6480464 | RNF4 protein promotes the reaction [Arsenic results in increased degradation of PML protein] | CTD | PMID:18408734 | arsenic atom | increases degradation | ISO | RGD:1345145 | 6480464 | Arsenic results in increased degradation of PML protein | CTD | PMID:18408734 | benzo[a]pyrene | increases expression | ISO | RGD:1557220 | 6480464 | Benzo(a)pyrene results in increased expression of PML mRNA | CTD | PMID:19770486 PMID:20713471 | benzo[a]pyrene | decreases expression | ISO | RGD:1557220 | 6480464 | Benzo(a)pyrene results in decreased expression of PML mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | RGD:1557220 | 6480464 | Benzo(a)pyrene results in increased expression of PML mRNA | CTD | PMID:19770486 more ... | benzo[a]pyrene | increases expression | ISO | RGD:1557220 | 6480464 | Benzo(a)pyrene results in increased expression of PML mRNA | CTD | PMID:20713471 PMID:19770486 | benzo[a]pyrene | increases expression | ISO | RGD:1557220 | 6480464 | Benzo(a)pyrene results in increased expression of PML mRNA | CTD | PMID:20713471 | calciol | multiple interactions | ISO | RGD:1345145 | 6480464 | PML protein mutant form inhibits the reaction [[Cholecalciferol co-treated with TGFB1 protein] results in increased expression of CD14 mRNA] | CTD | PMID:15988048 | cisplatin | increases expression | ISO | RGD:1557220 | 6480464 | Cisplatin results in increased expression of PML mRNA | CTD | PMID:21151649 | cobalt dichloride | multiple interactions | ISO | RGD:1345145 | 6480464 | cobaltous chloride promotes the reaction [arsenic trioxide results in increased degradation of PML protein mutant form] | CTD | PMID:16330433 | diarsenic trioxide | affects localization | ISO | RGD:1345145 | 6480464 | arsenic trioxide affects the localization of PML protein | CTD | PMID:20943951 more ... | diarsenic trioxide | increases ubiquitination | ISO | RGD:1345145 | 6480464 | arsenic trioxide results in increased ubiquitination of PML protein | CTD | PMID:20378816 | diarsenic trioxide | increases sumoylation | ISO | RGD:1345145 | 6480464 | arsenic trioxide results in increased sumoylation of PML protein | CTD | PMID:17081986 more ... | diarsenic trioxide | increases degradation | ISO | RGD:1345145 | 6480464 | arsenic trioxide results in increased degradation of PML protein | CTD | PMID:20378816 | diarsenic trioxide | multiple interactions | ISO | RGD:1345145 | 6480464 | arsenic trioxide inhibits the reaction [p-aminophenylarsine oxide binds to PML protein]; more ... | CTD | PMID:20378816 | diarsenic trioxide | increases expression | ISO | RGD:1557220 | 6480464 | arsenic trioxide results in increased expression of PML mRNA | CTD | PMID:21921037 | diarsenic trioxide | increases degradation | ISO | RGD:1557220 | 6480464 | arsenic trioxide results in increased degradation of PML protein | CTD | PMID:21921037 | diarsenic trioxide | affects binding | ISO | RGD:1345145 | 6480464 | arsenic trioxide binds to PML protein | CTD | PMID:20378816 | diarsenic trioxide | increases degradation | ISO | RGD:1345145 | 6480464 | arsenic trioxide results in increased degradation of PML protein mutant form | CTD | PMID:15748426 more ... | diarsenic trioxide | increases degradation | ISO | RGD:1345145 | 6480464 | arsenic trioxide results in increased degradation of PML protein mutant form | CTD | PMID:17217047 more ... | diarsenic trioxide | increases sumoylation | ISO | RGD:1345145 | 6480464 | arsenic trioxide results in increased sumoylation of PML protein | CTD | PMID:20943951 PMID:17081986 | diarsenic trioxide | increases degradation | ISO | RGD:1345145 | 6480464 | arsenic trioxide results in increased degradation of PML protein mutant form | CTD | PMID:16891316 more ... | diarsenic trioxide | affects localization | ISO | RGD:1345145 | 6480464 | arsenic trioxide affects the localization of PML protein | CTD | PMID:8704214 more ... | diarsenic trioxide | decreases expression | ISO | RGD:1557220 | 6480464 | arsenic trioxide results in decreased expression of PML protein | CTD | PMID:18469801 | diarsenic trioxide | multiple interactions | ISO | RGD:1345145 | 6480464 | [Tretinoin co-treated with arsenic trioxide] results in decreased expression of PML mRNA alternative form | CTD | PMID:19225113 | diarsenic trioxide | affects response to substance | ISO | RGD:1345145 | 6480464 | PML protein affects the susceptibility to arsenic trioxide | CTD | PMID:21217775 | diarsenic trioxide | multiple interactions | ISO | RGD:1345145 | 6480464 | cobaltous chloride promotes the reaction [arsenic trioxide results in increased degradation of PML protein mutant form] | CTD | PMID:16330433 | diarsenic trioxide | increases sumoylation | ISO | RGD:1345145 | 6480464 | arsenic trioxide results in increased sumoylation of PML protein | CTD | PMID:17081986 PMID:20943951 | diarsenic trioxide | multiple interactions | ISO | RGD:1345145 | 6480464 | arsenic trioxide results in increased phosphorylation of and results in increased sumoylation of PML protein | CTD | PMID:15093545 | diarsenic trioxide | increases expression | ISO | RGD:1345145 | 6480464 | arsenic trioxide results in increased expression of PML protein modified form | CTD | PMID:20943951 | diarsenic trioxide | multiple interactions | ISO | RGD:1345145 | 6480464 | arsenic trioxide results in increased localization of and results in increased degradation of PML protein | CTD | PMID:9716575 | diarsenic trioxide | multiple interactions | ISO | RGD:1345145 | 6480464 | arsenic trioxide promotes the reaction [RNF4 protein results in increased degradation of PML protein] | CTD | PMID:20943951 | diarsenic trioxide | increases degradation | ISO | RGD:1345145 | 6480464 | arsenic trioxide results in increased degradation of PML protein mutant form | CTD | PMID:9834237 more ... | diarsenic trioxide | multiple interactions | ISO | RGD:1345145 | 6480464 | arsenic trioxide promotes the reaction [SUMO1 protein binds to PML protein] | CTD | PMID:9834237 | diarsenic trioxide | multiple interactions | ISO | RGD:1345145 | 6480464 | arsenic trioxide promotes the reaction [puerarin results in decreased expression of PML mRNA alternative form] | CTD | PMID:20416161 | diarsenic trioxide | affects metabolic processing | ISO | RGD:1345145 | 6480464 | arsenic trioxide affects the metabolism of PML protein | CTD | PMID:21217775 | diarsenic trioxide | affects binding | ISO | RGD:1345145 | 6480464 | arsenic trioxide binds to PML protein modified form | CTD | PMID:15748426 | diarsenic trioxide | multiple interactions | ISO | RGD:1345145 | 6480464 | arsenic trioxide affects the reaction [PML protein modified form binds to DAXX protein] | CTD | PMID:17081986 | diarsenic trioxide | multiple interactions | ISO | RGD:1345145 | 6480464 | [arsenic trioxide co-treated with PML protein] results in decreased expression of BCL2; more ... | CTD | PMID:20377131 | diarsenic trioxide | affects localization | ISO | RGD:1345145 | 6480464 | arsenic trioxide affects the localization of PML protein | CTD | PMID:9834237 more ... | diarsenic trioxide | affects localization | ISO | RGD:1345145 | 6480464 | arsenic trioxide affects the localization of PML protein | CTD | PMID:20943951 more ... | diarsenic trioxide | increases degradation | ISO | RGD:1345145 | 6480464 | arsenic trioxide results in increased degradation of PML protein mutant form | CTD | PMID:9834237 more ... | dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate | increases degradation | ISO | RGD:1345145 | 6480464 | Antimony Potassium Tartrate results in increased degradation of PML protein mutant form | CTD | PMID:9834237 | dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate | affects localization | ISO | RGD:1345145 | 6480464 | Antimony Potassium Tartrate affects the localization of PML protein | CTD | PMID:9834237 | dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate | multiple interactions | ISO | RGD:1345145 | 6480464 | Antimony Potassium Tartrate promotes the reaction [SUMO1 protein binds to PML protein] | CTD | PMID:9834237 | elemental selenium | multiple interactions | ISO | RGD:1345145 | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of PML mRNA | CTD | PMID:19244175 | elemental selenium | increases expression | ISO | RGD:1345145 | 6480464 | Selenium results in increased expression of PML mRNA | CTD | PMID:19244175 | ellagic acid | decreases expression | ISO | RGD:1345145 | 6480464 | Ellagic Acid results in decreased expression of PML mRNA | CTD | PMID:12002526 | ibuprofen | affects expression | ISO | RGD:1345145 | 6480464 | Ibuprofen affects the expression of PML mRNA | CTD | PMID:17070997 | mitoxantrone | affects mutagenesis | ISO | RGD:1345145 | 6480464 | Mitoxantrone affects the mutagenesis of PML gene | CTD | PMID:19884644 | N-nitrosodiethylamine | increases expression | ISO | RGD:1557220 | 6480464 | Diethylnitrosamine results in increased expression of PML mRNA | CTD | PMID:17854601 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:1557220 | 6480464 | RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PML mRNA] | CTD | PMID:17854601 | pirinixic acid | decreases expression | ISO | RGD:1557220 | 6480464 | pirinixic acid results in decreased expression of PML mRNA | CTD | PMID:17426115 | propiconazole | decreases expression | ISO | RGD:1557220 | 6480464 | propiconazole results in decreased expression of PML mRNA | CTD | PMID:21278054 | resveratrol | multiple interactions | ISO | RGD:1345145 | 6480464 | BCL2 protein inhibits the reaction [resveratrol promotes the reaction [PML protein binds to CREBBP protein]]; more ... | CTD | PMID:19631782 | selenium atom | multiple interactions | ISO | RGD:1345145 | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of PML mRNA | CTD | PMID:19244175 | selenium atom | increases expression | ISO | RGD:1345145 | 6480464 | Selenium results in increased expression of PML mRNA | CTD | PMID:19244175 | sulindac | increases expression | ISO | RGD:1345145 | 6480464 | Sulindac results in increased expression of PML mRNA | CTD | PMID:16273229 | trans-resveratrol | multiple interactions | ISO | RGD:1345145 | 6480464 | BCL2 protein inhibits the reaction [resveratrol promotes the reaction [PML protein binds to CREBBP protein]]; more ... | CTD | PMID:19631782 | valproic acid | affects expression | ISO | RGD:1557220 | 6480464 | Valproic Acid affects the expression of PML mRNA | CTD | PMID:17963808 | vanadyl sulfate | decreases expression | ISO | RGD:1345145 | 6480464 | vanadyl sulfate results in decreased expression of PML mRNA | CTD | PMID:16330358 | zebularine | decreases expression | ISO | RGD:1345145 | 6480464 | pyrimidin-2-one beta-ribofuranoside results in decreased expression of PML mRNA | CTD | PMID:19194470 | zinc atom | increases expression | ISO | RGD:1345145 | 6480464 | Zinc results in increased expression of PML protein mutant form | CTD | PMID:16330433 | zinc(0) | increases expression | ISO | RGD:1345145 | 6480464 | Zinc results in increased expression of PML protein mutant form | CTD | PMID:16330433 | | |||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsBiological Process











