Map1lc3a (microtubule-associated protein 1 light chain 3 alpha) - Rat Genome Database

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Gene: Map1lc3a (microtubule-associated protein 1 light chain 3 alpha) Rattus norvegicus
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Symbol: Map1lc3a
Name: microtubule-associated protein 1 light chain 3 alpha
RGD ID: 735183
Description: Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to nutrient levels; and intracellular signaling cassette. Located in autophagosome membrane and late endosome. Is active in glutamatergic synapse. Biomarker of several diseases, including artery disease (multiple); degenerative disc disease; ischemia (multiple); retinal detachment; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha); PARTICIPATES IN autophagy pathway; INTERACTS WITH 1,3-dichloropropan-2-ol; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: autophagy-related protein LC3 A; autophagy-related ubiquitin-like modifier LC3 A; LC3-I; LC3-II; LC3A; MAP1 light chain 3-like protein 1; MAP1A/1B light chain 3 A; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; MGC105263; microtubule-associated proteins 1A/1B light chain 3A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,243,204 - 164,244,850 (+)NCBIGRCr8
mRatBN7.23143,783,024 - 143,784,670 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,783,024 - 143,784,670 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,649,095 - 147,650,741 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,266,376 - 156,268,022 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,005,913 - 154,007,559 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,801,289 - 150,802,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,801,289 - 150,802,935 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,169,534 - 157,171,180 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,758,939 - 145,760,532 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13145,664,573 - 145,666,154 (+)NCBI
Celera3142,510,304 - 142,511,947 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methyladenine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-aminopyridine  (EXP)
4-nonylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
abamectin  (EXP)
acadesine  (ISO)
acetamide  (EXP)
acrylonitrile  (ISO)
aflatoxin B1  (ISO)
Alisol B  (ISO)
allethrin  (EXP)
alpha,alpha-trehalose  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
calyculin a  (ISO)
capsaicin  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cyfluthrin  (EXP,ISO)
cypermethrin  (EXP,ISO)
dactolisib  (ISO)
DDE  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dihydrocapsaicin  (ISO)
Doramectin  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
ferric oxide  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hesperidin  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
LY294002  (ISO)
melatonin  (ISO)
methidathion  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
Nonylphenol  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
ponatinib  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (EXP)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trovafloxacin  (ISO)
uranium atom  (ISO)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
XL147  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
autophagy pathway  (IEP,ISO)

References

References - curated
# Reference Title Reference Citation
1. Network organization of the human autophagy system. Behrends C, etal., Nature. 2010 Jul 1;466(7302):68-76. Epub 2010 Jun 20.
2. Noggin attenuates cerulein-induced acute pancreatitis and impaired autophagy. Cao Y, etal., Pancreas. 2013 Mar;42(2):301-7. doi: 10.1097/MPA.0b013e31825b9f2c.
3. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Castillo K, etal., Autophagy. 2013 Sep;9(9):1308-20. doi: 10.4161/auto.25188. Epub 2013 Jun 6.
4. Induction of autophagic cell death in the rat brain caused by iron. Chen G, etal., Am J Med Sci. 2013 May;345(5):369-74. doi: 10.1097/MAJ.0b013e318271c031.
5. Cold ischemia-induced autophagy in rat lung tissue. Chen X, etal., Mol Med Rep. 2015 Apr;11(4):2513-9. doi: 10.3892/mmr.2014.2999. Epub 2014 Nov 26.
6. Propofol prevents autophagic cell death following oxygen and glucose deprivation in PC12 cells and cerebral ischemia-reperfusion injury in rats. Cui D, etal., PLoS One. 2012;7(4):e35324. doi: 10.1371/journal.pone.0035324. Epub 2012 Apr 11.
7. Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans. Gassen NC, etal., PLoS Med. 2014 Nov 11;11(11):e1001755. doi: 10.1371/journal.pmed.1001755. eCollection 2014 Nov.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Valproic acid reduces autophagy and promotes functional recovery after spinal cord injury in rats. Hao HH, etal., Neurosci Bull. 2013 Aug;29(4):484-92. doi: 10.1007/s12264-013-1355-6. Epub 2013 Jul 13.
10. Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Hariharan N, etal., Antioxid Redox Signal. 2011 Jun;14(11):2179-90. doi: 10.1089/ars.2010.3488. Epub 2011 Jan 27.
11. Acute spinal cord injury in rats should target activated autophagy. Hou H, etal., J Neurosurg Spine. 2014 May;20(5):568-77. doi: 10.3171/2014.1.SPINE13237. Epub 2014 Feb 21.
12. Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. Jiang M, etal., Am J Pathol. 2010 Mar;176(3):1181-92. doi: 10.2353/ajpath.2010.090594. Epub 2010 Jan 14.
13. Angiotensin-(1-7) inhibits autophagy in the brain of spontaneously hypertensive rats. Jiang T, etal., Pharmacol Res. 2013 May;71:61-8. doi: 10.1016/j.phrs.2013.03.001. Epub 2013 Mar 15.
14. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. Kabeya Y, etal., EMBO J. 2000 Nov 1;19(21):5720-8.
15. Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration. Kitaoka Y, etal., Cell Death Dis. 2013 Oct 17;4:e860. doi: 10.1038/cddis.2013.391.
16. Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Kochl R, etal., Traffic. 2006 Feb;7(2):129-45.
17. [Changes in expression of autophagy-related proteins, Beclin-1 and LC3, and effects of rapamycin on their expression in hypoxic-ischemic hippocampus]. Li RH, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2015 Apr;17(4):400-4.
18. Tougu Xiaotong capsule inhibits the tidemark replication and cartilage degradation of papain-induced osteoarthritis by the regulation of chondrocyte autophagy. Li X, etal., Int J Mol Med. 2013 Jun;31(6):1349-56. doi: 10.3892/ijmm.2013.1341. Epub 2013 Apr 9.
19. The Effect of Autophagy on Inflammation Cytokines in Renal Ischemia/Reperfusion Injury. Ling H, etal., Inflammation. 2016 Feb;39(1):347-56. doi: 10.1007/s10753-015-0255-5.
20. Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking. Liu R, etal., Autophagy. 2014 Jul;10(7):1241-55. doi: 10.4161/auto.28912. Epub 2014 May 15.
21. Acute hyperglycemia together with hematoma of high-glucose blood exacerbates neurological injury in a rat model of intracerebral hemorrhage. Liu RY, etal., Neurosci Bull. 2014 Feb;30(1):90-8. doi: 10.1007/s12264-013-1371-6. Epub 2013 Jul 25.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Protective effect of Dl-3n-butylphthalide on learning and memory impairment induced by chronic intermittent hypoxia-hypercapnia exposure. Min JJ, etal., Sci Rep. 2014 Jul 3;4:5555. doi: 10.1038/srep05555.
24. In vitro reconstitution of fusion between immature autophagosomes and endosomes. Morvan J, etal., Autophagy. 2009 Jul;5(5):676-89. Epub 2009 Jul 6.
25. Propofol protects the autophagic cell death induced by the ischemia/reperfusion injury in rats. Noh HS, etal., Mol Cells. 2010 Nov;30(5):455-60. doi: 10.1007/s10059-010-0130-z. Epub 2010 Sep 2.
26. Autophagy, and BiP level decrease are early key events in retrograde degeneration of motoneurons. Penas C, etal., Cell Death Differ. 2011 Oct;18(10):1617-27. doi: 10.1038/cdd.2011.24. Epub 2011 Mar 25.
27. Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis. Qiu J, etal., Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8):E983-93. doi: 10.1152/ajpendo.00183.2012. Epub 2012 Aug 14.
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins. Seidenbecher CI, etal., J Mol Biol. 2004 Feb 27;336(4):957-70. doi: 10.1016/j.jmb.2003.12.054.
31. TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death. Seillier M, etal., Cell Death Differ. 2012 Sep;19(9):1525-35. doi: 10.1038/cdd.2012.30. Epub 2012 Mar 16.
32. Hypoxia inducible factor 1alpha contributes to regulation of autophagy in retinal detachment. Shelby SJ, etal., Exp Eye Res. 2015 Aug;137:84-93. doi: 10.1016/j.exer.2015.06.016. Epub 2015 Jun 17.
33. MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1. Song L, etal., J Cell Mol Med. 2014 Nov;18(11):2266-74. doi: 10.1111/jcmm.12380. Epub 2014 Sep 11.
34. The effects of BMSCs transplantation on autophagy by CX43 in the hippocampus following traumatic brain injury in rats. Sun L, etal., Neurol Sci. 2014 May;35(5):677-82. doi: 10.1007/s10072-013-1575-6. Epub 2013 Nov 13.
35. Association of membrane rafts and postsynaptic density: proteomics, biochemical, and ultrastructural analyses. Suzuki T, etal., J Neurochem. 2011 Oct;119(1):64-77. doi: 10.1111/j.1471-4159.2011.07404.x. Epub 2011 Aug 22.
36. LC3 conjugation system in mammalian autophagy. Tanida I, etal., Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18.
37. HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. Tanida I, etal., J Biol Chem 2004 Aug 27;279(35):36268-76. Epub 2004 Jun 08.
38. Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and JNK activation. Trejo-Solis C, etal., BMC Cancer. 2012 Apr 27;12:156. doi: 10.1186/1471-2407-12-156.
39. Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice. Weng LQ, etal., Acta Pharmacol Sin. 2014 Aug;35(8):1005-14. doi: 10.1038/aps.2014.45. Epub 2014 Jul 7.
40. Autophagy in the heart and liver during normal aging and calorie restriction. Wohlgemuth SE, etal., Rejuvenation Res. 2007 Sep;10(3):281-92.
41. Molecular cloning and characterization of rat LC3A and LC3B--two novel markers of autophagosome. Wu J, etal., Biochem Biophys Res Commun. 2006 Jan 6;339(1):437-42. Epub 2005 Nov 14.
42. Role of autophagy and apoptosis in wound tissue of deep second-degree burn in rats. Xiao M, etal., Acad Emerg Med. 2014 Apr;21(4):383-91. doi: 10.1111/acem.12352.
43. Autophagy and apoptosis in tubular cells following unilateral ureteral obstruction are associated with mitochondrial oxidative stress. Xu Y, etal., Int J Mol Med. 2013 Mar;31(3):628-36. doi: 10.3892/ijmm.2013.1232. Epub 2013 Jan 8.
44. Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells. Xue LX, etal., Biochem Biophys Res Commun. 2016 Nov 18;480(3):355-361. doi: 10.1016/j.bbrc.2016.10.050. Epub 2016 Oct 18.
45. Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: ameliorating effects of (-)-epigallocatechin-3-gallate. Yan J, etal., J Nutr Biochem. 2012 Jul;23(7):716-24. doi: 10.1016/j.jnutbio.2011.03.014. Epub 2011 Aug 4.
46. Increased macroautophagy in the pathological process of intervertebral disc degeneration in rats. Ye W, etal., Connect Tissue Res. 2013;54(1):22-8. doi: 10.3109/03008207.2012.715702. Epub 2012 Aug 23.
47. [Effect of chronic lead exposure on expression of autophagy-associated proteins in rat hippocampus]. Ye WF, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2012 Jul;41(4):402-9.
48. Induction of neuronal mitophagy in acute spinal cord injury in rats. Yu D, etal., Neurotox Res. 2013 Nov;24(4):512-22. doi: 10.1007/s12640-013-9397-0. Epub 2013 Apr 30.
49. Expression of LC3 and Beclin 1 in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain. Zhang E, etal., Brain Res. 2013 Jun 26;1519:31-9. doi: 10.1016/j.brainres.2013.04.055. Epub 2013 May 8.
50. Myocardial autophagy variation during acute myocardial infarction in rats: the effects of carvedilol. Zhang JL, etal., Chin Med J (Engl). 2009 Oct 5;122(19):2372-9.
51. Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation. Zhang M, etal., Apoptosis. 2013 Apr;18(4):423-34. doi: 10.1007/s10495-013-0811-0.
52. Morphine induces Beclin 1- and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus. Zhao L, etal., Autophagy. 2010 Apr;6(3):386-94. Epub 2010 Apr 25.
Additional References at PubMed
PMID:7908909   PMID:12477932   PMID:12740394   PMID:15489334   PMID:15755735   PMID:16303767   PMID:19056683   PMID:19366727   PMID:20132792   PMID:20204693   PMID:21220506   PMID:21455601  
PMID:21502359   PMID:21631941   PMID:22005460   PMID:22267086   PMID:22456507   PMID:22496425   PMID:23093945   PMID:24290141   PMID:24713655   PMID:24954904   PMID:25062852   PMID:25127057  
PMID:25327288   PMID:26018745   PMID:26179070   PMID:26237084   PMID:26284810   PMID:27889640   PMID:27994061   PMID:28223137   PMID:28578340   PMID:30134829   PMID:31006538   PMID:33236922  
PMID:33673233  


Genomics

Comparative Map Data
Map1lc3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,243,204 - 164,244,850 (+)NCBIGRCr8
mRatBN7.23143,783,024 - 143,784,670 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,783,024 - 143,784,670 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,649,095 - 147,650,741 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,266,376 - 156,268,022 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,005,913 - 154,007,559 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,801,289 - 150,802,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,801,289 - 150,802,935 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,169,534 - 157,171,180 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,758,939 - 145,760,532 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13145,664,573 - 145,666,154 (+)NCBI
Celera3142,510,304 - 142,511,947 (+)NCBICelera
Cytogenetic Map3q41NCBI
MAP1LC3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382034,546,844 - 34,560,345 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2034,546,854 - 34,560,345 (+)EnsemblGRCh38hg38GRCh38
GRCh372033,134,648 - 33,148,149 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,598,353 - 32,611,810 (+)NCBINCBI36Build 36hg18NCBI36
Build 342032,598,352 - 32,611,810NCBI
Celera2029,883,843 - 29,897,277 (+)NCBICelera
Cytogenetic Map20q11.22ENTREZGENE
HuRef2029,915,307 - 29,928,698 (+)NCBIHuRef
CHM1_12033,035,525 - 33,048,963 (+)NCBICHM1_1
T2T-CHM13v2.02036,270,022 - 36,283,500 (+)NCBIT2T-CHM13v2.0
Map1lc3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,118,284 - 155,119,993 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,118,217 - 155,119,993 (+)EnsemblGRCm39 Ensembl
GRCm382155,276,364 - 155,278,073 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,276,297 - 155,278,073 (+)EnsemblGRCm38mm10GRCm38
MGSCv372155,102,180 - 155,103,809 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362154,967,905 - 154,969,511 (+)NCBIMGSCv36mm8
Celera2161,209,000 - 161,210,629 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.18NCBI
Map1lc3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,774,922 - 26,775,884 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542226,774,466 - 26,776,024 (-)NCBIChiLan1.0ChiLan1.0
MAP1LC3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22140,290,956 - 40,293,402 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12040,284,784 - 40,286,504 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02030,887,345 - 30,888,986 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12032,018,279 - 32,020,411 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2032,010,284 - 32,020,411 (+)Ensemblpanpan1.1panPan2
MAP1LC3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12423,672,343 - 23,673,937 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,633,579 - 23,673,921 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2423,317,942 - 23,319,526 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02424,362,848 - 24,364,432 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2424,323,853 - 24,364,441 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12423,650,207 - 23,651,791 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02423,745,306 - 23,746,891 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02424,184,229 - 24,185,813 (+)NCBIUU_Cfam_GSD_1.0
Map1lc3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640172,643,168 - 172,644,801 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365616,104,742 - 6,106,699 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365616,104,748 - 6,106,348 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP1LC3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1737,957,507 - 37,959,505 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11737,957,830 - 37,959,505 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,155,847 - 43,157,522 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP1LC3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1238,857,235 - 38,858,955 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl238,857,299 - 38,858,505 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605087,971,860 - 87,974,126 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map1lc3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248424,800,539 - 4,802,094 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248424,800,533 - 4,802,235 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map1lc3a
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:50
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000035060
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat

Markers in Region
RH128169  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23143,784,414 - 143,784,625 (+)MAPPERmRatBN7.2
Rnor_6.03150,802,680 - 150,802,890NCBIRnor6.0
Rnor_5.03157,170,925 - 157,171,135UniSTSRnor5.0
RGSC_v3.43145,760,277 - 145,760,487UniSTSRGSC3.4
Celera3142,511,692 - 142,511,902UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000035060   ⟹   ENSRNOP00000032429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,783,024 - 143,784,670 (+)Ensembl
Rnor_6.0 Ensembl3150,801,289 - 150,802,935 (+)Ensembl
RefSeq Acc Id: NM_199500   ⟹   NP_955794
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,243,204 - 164,244,850 (+)NCBI
mRatBN7.23143,783,024 - 143,784,670 (+)NCBI
Rnor_6.03150,801,289 - 150,802,935 (+)NCBI
Rnor_5.03157,169,534 - 157,171,180 (+)NCBI
RGSC_v3.43145,758,939 - 145,760,532 (+)RGD
Celera3142,510,304 - 142,511,947 (+)NCBI
Sequence:
RefSeq Acc Id: NP_955794   ⟸   NM_199500
- UniProtKB: Q6XVN8 (UniProtKB/Swiss-Prot),   A6KI25 (UniProtKB/TrEMBL),   A6KI24 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000032429   ⟸   ENSRNOT00000035060

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6XVN8-F1-model_v2 AlphaFold Q6XVN8 1-121 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692581
Promoter ID:EPDNEW_R3106
Type:initiation region
Name:Map1lc3a_1
Description:microtubule-associated protein 1 light chain 3 alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03150,801,311 - 150,801,371EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735183 AgrOrtholog
BioCyc Gene G2FUF-47145 BioCyc
Ensembl Genes ENSRNOG00000025443 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055024242 UniProtKB/Swiss-Prot
  ENSRNOG00060027125 UniProtKB/Swiss-Prot
  ENSRNOG00065028129 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000035060 ENTREZGENE
  ENSRNOT00000035060.5 UniProtKB/Swiss-Prot
  ENSRNOT00055041616 UniProtKB/Swiss-Prot
  ENSRNOT00060047048 UniProtKB/Swiss-Prot
  ENSRNOT00065048479 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7302206 IMAGE-MGC_LOAD
InterPro Atg8-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:362245 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105263 IMAGE-MGC_LOAD
NCBI Gene 362245 ENTREZGENE
PANTHER MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED UniProtKB/TrEMBL
  MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10969 UniProtKB/Swiss-Prot
Pfam Atg8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Map1lc3a PhenoGen
RatGTEx ENSRNOG00000025443 RatGTEx
  ENSRNOG00055024242 RatGTEx
  ENSRNOG00060027125 RatGTEx
  ENSRNOG00065028129 RatGTEx
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KI24 ENTREZGENE, UniProtKB/TrEMBL
  A6KI25 ENTREZGENE, UniProtKB/TrEMBL
  A6KI27_RAT UniProtKB/TrEMBL
  A6KI29_RAT UniProtKB/TrEMBL
  MLP3A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Map1lc3a  microtubule-associated protein 1 light chain 3 alpha      Symbol and Name status set to approved 1299863 APPROVED