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Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | aging | | IEP | | 2302033 | | RGD | | angiogenesis | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050 | RGD | MGI:MGI:1933434 PMID:11285230 | anterior/posterior pattern specification | | ISO | RGD:736083 | 1624291 | MGI:MGI:87912 | RGD | MGI:MGI:3695190 PMID:16845371 | apoptotic process | | IEA | UniProtKB-KW:KW-0053 | 1600115 | GO_REF:0000037 | UniProtKB | GO_REF:0000037 | artery morphogenesis | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050|MGI:MGI:2386570 | RGD | MGI:MGI:3703113 PMID:17078885 | blastocyst development | | ISO | RGD:736083 | 1624291 | MGI:MGI:1326851|PMID:9921650 | RGD | MGI:MGI:1326851 PMID:9921650 | cell differentiation | | IEA | UniProtKB-KW:KW-0221 | 1600115 | GO_REF:0000037 | UniProtKB | GO_REF:0000037 | cellular response to transforming growth factor beta stimulus | | ISO | RGD:736083 | 1624291 | MGI:MGI:3848261|PMID:19494318 | RGD | MGI:MGI:3848261 PMID:19494318 | collagen fibril organization | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050 | RGD | MGI:MGI:3588906 PMID:15993878 | digestive tract development | | IEP | | 2302031 | | RGD | | embryo development | | IEP | | 2302023 | | RGD | | embryo development | | ISO | RGD:736083 | 1624291 | MGI:MGI:3613461 | RGD | MGI:MGI:3613125 PMID:16344855 | embryo development | | ISO | RGD:736083 | 1624291 | MGI:MGI:2686855|PMID:14729481 | RGD | MGI:MGI:2686855 PMID:14729481 | embryo implantation | | IEP | | 1601594 | | RGD | | embryonic cranial skeleton morphogenesis | | ISO | RGD:736083 | 1624291 | MGI:MGI:2680164 | RGD | MGI:MGI:3701721 PMID:16806156 | endothelial cell migration | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050 | RGD | MGI:MGI:1933434 PMID:11285230 | germ cell migration | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050 | RGD | MGI:MGI:3588906 PMID:15993878 | heart development | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050|MGI:MGI:2386570 | RGD | MGI:MGI:3703113 PMID:17078885 | in utero embryonic development | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050 | RGD | MGI:MGI:1933434 PMID:11285230 | in utero embryonic development | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050|MGI:MGI:2386570 | RGD | MGI:MGI:3703113 PMID:17078885 | in utero embryonic development | | ISO | RGD:736083 | 1624291 | MGI:MGI:2686855|PMID:14729481 | RGD | MGI:MGI:2686855 PMID:14729481 | induction of apoptosis | | ISO | RGD:736083 | 1624291 | MGI:MGI:2680164 | RGD | MGI:MGI:3701721 PMID:16806156 | kidney development | | ISO | RGD:736083 | 1624291 | MGI:MGI:87912 | RGD | MGI:MGI:3695190 PMID:16845371 | lens development in camera-type eye | | ISO | RGD:736083 | 1624291 | MGI:MGI:2151112|PMID:11641223 | RGD | MGI:MGI:2151112 PMID:11641223 | lung development | | IEP | | 2302034 | | RGD | | negative regulation of apoptotic process | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050|MGI:MGI:2386570 | RGD | MGI:MGI:3703113 PMID:17078885 | negative regulation of chondrocyte differentiation | | ISO | RGD:736083 | 1624291 | MGI:MGI:3848261|PMID:19494318 | RGD | MGI:MGI:3848261 PMID:19494318 | negative regulation of endothelial cell differentiation | | IMP | | 2302022 | | RGD | | negative regulation of endothelial cell proliferation | | ISO | RGD:736083 | 1624291 | MGI:MGI:107571 | RGD | MGI:MGI:5298182 PMID:21832243 | neuron fate commitment | | ISO | RGD:736083 | 1624291 | MGI:MGI:3588127|PMID:15744664 | RGD | MGI:MGI:3588127 PMID:15744664 | organ regeneration | | IEP | | 2302035 | | RGD | | palate development | | ISO | RGD:736083 | 1624291 | MGI:MGI:87912 | RGD | MGI:MGI:3695190 PMID:16845371 | palate development | | ISO | RGD:736083 | 1624291 | MGI:MGI:2680164|MGI:MGI:2388050 | RGD | MGI:MGI:3701721 PMID:16806156 | parathyroid gland development | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050|MGI:MGI:2386570 | RGD | MGI:MGI:3703113 PMID:17078885 | pharyngeal system development | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050|MGI:MGI:2386570 | RGD | MGI:MGI:3703113 PMID:17078885 | positive regulation of filopodium assembly | | ISO | RGD:736083 | 1624291 | MGI:MGI:2680164 | RGD | MGI:MGI:3701721 PMID:16806156 | post-embryonic development | | ISO | RGD:736083 | 1624291 | MGI:MGI:2680164|MGI:MGI:2388050 | RGD | MGI:MGI:3701721 PMID:16806156 | protein autophosphorylation | | IMP | | 737663 | | RGD | | protein phosphorylation | | IMP | | 2302021 | | RGD | | protein phosphorylation | | ISO | RGD:736083 | 1624291 | MGI:MGI:3575204|PMID:15820682 | RGD | MGI:MGI:3575204 PMID:15820682 | regulation of apoptotic process | | ISO | RGD:736083 | 1624291 | MGI:MGI:2680164 | RGD | MGI:MGI:3701721 PMID:16806156 | regulation of gene expression | | ISO | RGD:736083 | 1624291 | MGI:MGI:2680164 | RGD | MGI:MGI:3701721 PMID:16806156 | regulation of growth | | IEA | UniProtKB-KW:KW-0341 | 1600115 | GO_REF:0000037 | UniProtKB | GO_REF:0000037 | regulation of protein binding | | ISO | RGD:736083 | 1624291 | MGI:MGI:3628833|PMID:16601693 | RGD | MGI:MGI:3628833 PMID:16601693 | response to cholesterol | | ISO | RGD:736083 | 1624291 | MGI:MGI:3766844|PMID:17878231 | RGD | MGI:MGI:3766844 PMID:17878231 | response to electrical stimulus | | IEP | | 2302025 | | RGD | | response to estrogen stimulus | | IDA | | 730144 | | RGD | | response to hypoxia | | IEP | | 2302018 | | RGD | | response to organic cyclic compound | | IEP | | 2302028 | | RGD | | response to prostaglandin E stimulus | | IEP | | 2302028 | | RGD | | response to toxic substance | | IEP | | 2302025 | | RGD | | skeletal system development | | ISO | RGD:736083 | 1624291 | MGI:MGI:87912 | RGD | MGI:MGI:3695190 PMID:16845371 | skeletal system morphogenesis | | ISO | RGD:736083 | 1624291 | MGI:MGI:87912 | RGD | MGI:MGI:3695190 PMID:16845371 | thymus development | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050|MGI:MGI:2386570 | RGD | MGI:MGI:3703113 PMID:17078885 | transforming growth factor beta receptor signaling pathway | | IMP | | 2302517 | | RGD | | transforming growth factor beta receptor signaling pathway | | ISO | RGD:736083 | 1624291 | MGI:MGI:5298182|PMID:21832243 | RGD | MGI:MGI:5298182 PMID:21832243 | transforming growth factor beta receptor signaling pathway | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050|MGI:MGI:2386570 | RGD | MGI:MGI:3703113 PMID:17078885 | transforming growth factor beta receptor signaling pathway | | ISO | RGD:736083 | 1624291 | MGI:MGI:2388050 | RGD | MGI:MGI:1933434 PMID:11285230 | transforming growth factor beta receptor signaling pathway | | ISO | RGD:736083 | 1624291 | MGI:MGI:3575204|PMID:15820682 | RGD | MGI:MGI:3575204 PMID:15820682 | transforming growth factor beta receptor signaling pathway | | ISO | RGD:736083 | 1624291 | MGI:MGI:2679137|PMID:14580334 | RGD | MGI:MGI:2679137 PMID:14580334 | transforming growth factor beta receptor signaling pathway | | IMP | | 2302021 | | RGD | | transforming growth factor beta receptor signaling pathway | | IMP | | 737663 | | RGD | | | 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Molecular Pathway Annotations
Disease Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Adherens junction |
| Chagas disease (American trypanosomiasis) | |
| Chronic myeloid leukemia | |
| Colorectal cancer | |
| Cytokine-cytokine receptor interaction | |
| Endocytosis | |
| Hepatitis B | |
| Hippo signaling pathway | |
| HTLV-I infection | |
| MAPK signaling pathway | |
| Osteoclast differentiation | |
| Pancreatic cancer | |
| Pathways in cancer | |
| TGF-beta signaling pathway | |
References - curated| 1. |
Akool el-S, etal., J Immunol. 2008 Aug 15;181(4):2831-45. |
| 2. |
Asano Y, etal., J Clin Invest. 2004 Jan;113(2):253-64. |
| 3. |
Bassing CH, etal., Science 1994 Jan 7;263(5143):87-9. |
| 4. |
Bonecini-Almeida MG, etal., Infect Immun. 2004 May;72(5):2628-34. |
| 5. |
Bouret S, etal., Neuroendocrinology 2002 Jul;76(1):1-7. |
| 6. |
Chen T, etal., Clin Cancer Res. 2006 Jan 15;12(2):392-7. |
| 7. |
Chen T, etal., Int J Cancer. 2004 Nov 10;112(3):420-5. |
| 8. |
Chen Y, etal., Am J Pathol. 2005 Dec;167(6):1699-711. |
| 9. |
Dahlman I, etal., Eur J Immunol 1998 Jul;28(7):2188-96 |
| 10. |
de Andrade Sa ER, etal., Dev Dyn. 2003 Jul;227(3):450-7. |
| 11. |
de Gouville AC, etal., Br J Pharmacol. 2005 May;145(2):166-77. |
| 12. |
Dell K, etal., Cytokine. 2003 Jun 21;22(6):189-93. |
| 13. |
Frazier K, etal., Toxicol Pathol. 2007;35(2):284-95. |
| 14. |
GOA data from the GO Consortium |
| 15. |
Gordon KJ and Blobe GC, Biochim Biophys Acta. 2008 Apr;1782(4):197-228. Epub 2008 Feb 11. |
| 16. |
Guo Q, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 Apr;23(4):317-9. |
| 17. |
Hartner A, etal., J Mol Med. 2003 Jan;81(1):32-42. Epub 2002 Dec 14. |
| 18. |
Hattori K, etal., Carcinogenesis. 1997 Oct;18(10):1867-70. |
| 19. |
He WW, etal., Dev Dyn 1993 Feb;196(2):133-42. |
| 20. |
Jude EB, etal., Diabet Med. 2002 Jun;19(6):440-7. |
| 21. |
Khalil N, etal., Exp Lung Res. 2002 Apr-May;28(3):233-50. |
| 22. |
Laping NJ, etal., Clin Cancer Res. 2007 May 15;13(10):3087-99. |
| 23. |
Li JJ, etal., Neuroscience. 2008 Oct 15;156(3):662-72. Epub 2008 Aug 6. |
| 24. |
Lin HY, etal., Life Sci. 2006 May 1;78(23):2669-75. Epub 2006 Jan 19. |
| 25. |
Liu FY, etal., Am J Nephrol. 2007;27(2):176-83. Epub 2007 Mar 7. |
| 26. |
Loeys BL, etal., Nat Genet. 2005 Mar;37(3):275-81. Epub 2005 Jan 30. |
| 27. |
MGD data from the GO Consortium |
| 28. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 29. |
Nishikawa Y, etal., J Cell Physiol. 1998 Sep;176(3):612-23. |
| 30. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 31. |
Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5 |
| 32. |
RGD automated data pipeline |
| 33. |
Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700. |
| 34. |
Ugarte G and Brandan E, J Biol Chem. 2006 Jul 7;281(27):18473-81. Epub 2006 May 8. |
| 35. |
Vicencio AG, etal., J Appl Physiol 2002 Sep;93(3):1123-30. |
| 36. |
Wang XN, etal., Zhong Xi Yi Jie He Xue Bao. 2005 Jul;3(4):286-9. |
| 37. |
Wilkes MC, etal., Mol Cell Biol. 2003 Dec;23(23):8878-89. |
| 38. |
Woszczyk D, etal., Med Sci Monit. 2004 Jan;10(1):CR33-7. |
| 39. |
Xia W, etal., J Biol Chem. 2006 Jun 16;281(24):16799-813. Epub 2006 Apr 13. |
| 40. |
Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20. |
| 41. |
Yoshida M, etal., Cell Tissue Res. 2007 Aug;329(2):273-82. Epub 2007 Apr 21. |
| 42. |
Zaiman AL, etal., Am J Respir Crit Care Med. 2008 Apr 15;177(8):896-905. Epub 2008 Jan 17. |
| 43. |
Zhang MF, etal., Pediatr Res. 1999 Dec;46(6):657-65. |
| 44. |
Zhang Y, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Dec;27(12):1094-8. |
| 45. |
Zhao H, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):482-91. |
| 46. |
Zhao H, etal., Biochem Biophys Res Commun. 2002 Jun 7;294(2):464-9. |
| 47. |
Zhao Y, etal., Am J Physiol Lung Cell Mol Physiol. 2000 Jun;278(6):L1231-9. |
References - uncurated| PubMed | 12477932 |
| 12923327 | |
| 16806744 | |
| 16897002 | |
| 16980036 | |
| 17878231 | |
| 17972267 | |
| 18292396 | |
| 18598696 | |
| 18832104 | |
| 19153267 | |
| 19270180 | |
| 20221422 | |
| 20386537 | |
| 21358634 | |
| 21859884 | |
| 8889548 |
RGD Disease Portals| Tgfbr1 has been annotated in the following RGD Disease Portals. |
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Candidate Gene Status
Comparative Map Data| Tgfbr1 (Rattus norvegicus) |
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| Tgfbr1 (Mus musculus) |
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Position Markers| D5Got230 |
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| AU017191 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_012775 | (Get FASTA) | Search GEO for Microarray Profiles |
| XM_003749940 | (Get FASTA) | Search GEO for Microarray Profiles | |
| XM_003754027 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06036914 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06036915 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06036959 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01036783 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC087035 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CB804748 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474056 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CK844086 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L26110 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012775 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_036907 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_003749940 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | XP_003749988 | ||||||||||
| Position: |
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| RefSeq Acc Id: | XM_003754027 |
| RefSeq Status: | |
| Type: | CODING |
| Protein Acc Id: | XP_003754075 |
| Position: | No map positions available. |
Protein Sequences| Protein RefSeqs | NP_036907 | (Get FASTA) |
| XP_003749988 | (Get FASTA) | |
| XP_003754075 | (Get FASTA) | |
| GenBank Protein | AAA83216 | (Get FASTA) |
| AAH87035 | (Get FASTA) | |
| EDL78209 | (Get FASTA) | |
| P80204 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000007036 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOG00000050760 | ENTREZGENE, UniProtKB/TrEMBL | |
| Ensembl Protein | ENSRNOP00000009452 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOP00000066202 | ENTREZGENE, UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000009452 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOT00000073192 | ENTREZGENE, UniProtKB/TrEMBL | |
| Entrez Gene | 29591 | ENTREZGENE |
| Germonline | ENSRNOG00000007036 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 3177 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7098473 | IMAGE-MGC_LOAD |
| InterPro | Activin_rcpt | UniProtKB/Swiss-Prot |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_AS | UniProtKB/Swiss-Prot | |
| TGF_beta_rcpt_GS | UniProtKB/Swiss-Prot | |
| IPI | IPI00195461 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:29591 | ENTREZGENE, UniProtKB/TrEMBL |
| MGC_CLONE | MGC:93659 | IMAGE-MGC_LOAD |
| Pfam | Activin_recp | UniProtKB/Swiss-Prot |
| Pkinase | UniProtKB/Swiss-Prot | |
| TGF_beta_GS | UniProtKB/Swiss-Prot | |
| PROSITE | PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| PS51256 | UniProtKB/Swiss-Prot | |
| SMART | SM00467 | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| UniGene | Rn.44402 | ENTREZGENE |
| UniProt | M0R9M6_RAT | UniProtKB/TrEMBL |
| Q5M9H3_RAT | UniProtKB/TrEMBL | |
| TGFR1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Tgfbr1 | transforming growth factor, beta receptor 1 | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | lacking in stroma of dorsal and ventral lobes of young prostates but present in the stroma of aging prostates | 70812 |
| More on Tgfbr1 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3852 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




