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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1bmultiple interactionsEXP 6480464CTD[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNAPMID:18253720
Cdkn1bdecreases expressionISOCDKN1B (Homo sapiens)6480464CTDFenofibrate results in decreased expression of CDKN1B proteinPMID:29134746
Cdkn1bmultiple interactionsISOCDKN1B (Homo sapiens)6480464CTDESR1 protein inhibits the reaction [Fenofibrate results in decreased expression of CDKN1B protein]; Estradiol inhibits the reaction [Fenofibrate results in decreased expression of CDKN1B protein]PMID:29134746
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