CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1))

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Keyword

Gene: CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)) Homo sapiens

Symbol:

CDKN1B

Name:

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Description:

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

CDKN4; cyclin-dependent kinase inhibitor 1b; cyclin-dependent kinase inhibitor 1B; KIP1; MEN1B; MEN4; OTTHUMP00000195098; OTTHUMP00000195099; P27KIP1

Orthologs:

Mus musculus : Cdkn1b (cyclin-dependent kinase inhibitor 1B) MGI
Rattus norvegicus : Cdkn1b (cyclin-dependent kinase inhibitor 1B)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	12	12,739,391 - 12,744,398	+	NCBI
Human Genome Assembly HuRef	12	12,639,893 - 12,644,900	+	NCBI
Human Genome Assembly GRCh37	12	12,870,302 - 12,875,305	+	NCBI
Human Genome Assembly Build 36	12	12,761,576 - 12,766,570	+	NCBI
Human Cytogenetic Map	12	p13.1-p12		NCBI
Human Genome Assembly	12	12,761,575 - 12,766,569		NCBI