Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ETNK2 mRNA] | CTD | PMID:31150632 | (1->4)-beta-D-glucan | multiple interactions | ISO | Etnk2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ETNK2 mRNA | CTD | PMID:36331819 | 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | o and p'-DDT results in increased expression of ETNK2 mRNA | CTD | PMID:19371625 | 1,2-dichloroethane | decreases expression | ISO | Etnk2 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of ETNK2 mRNA | CTD | PMID:28189721 and PMID:28960355 | 17beta-estradiol | decreases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of ETNK2 mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ETNK2 mRNA | CTD | PMID:32109520 and PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Etnk2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ETNK2 mRNA | CTD | PMID:28213091 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Etnk2 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of ETNK2 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ETNK2 gene] | CTD | PMID:25975270 and PMID:28213091 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Etnk2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of ETNK2 mRNA | CTD | PMID:24680724 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ETNK2 mRNA | CTD | PMID:20106945 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 4,4'-sulfonyldiphenol | decreases expression | ISO | Etnk2 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of ETNK2 mRNA | CTD | PMID:33297965 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Etnk2 (Mus musculus) | 6480464 | bisphenol S affects the methylation of ETNK2 gene | CTD | PMID:31683443 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | ETNK2 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of ETNK2 gene | CTD | PMID:31601247 | acrylamide | increases expression | ISO | Etnk2 (Mus musculus) | 6480464 | Acrylamide results in increased expression of ETNK2 mRNA | CTD | PMID:30807115 | aflatoxin B1 | affects expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of ETNK2 protein | CTD | PMID:20106945 | aflatoxin B1 | decreases methylation | ISO | ETNK2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of ETNK2 exon | CTD | PMID:30157460 | aflatoxin B1 | decreases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of ETNK2 mRNA | CTD | PMID:27153756 | aflatoxin B1 | decreases expression | ISO | Etnk2 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of ETNK2 mRNA | CTD | PMID:19770486 | antirheumatic drug | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of ETNK2 mRNA | CTD | PMID:24449571 | atrazine | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Atrazine results in increased expression of ETNK2 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | decreases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of ETNK2 mRNA | CTD | PMID:20106945 and PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | ETNK2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of ETNK2 exon | CTD | PMID:30157460 | benzo[a]pyrene | decreases methylation | ISO | ETNK2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of ETNK2 3' UTR more ... | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of ETNK2 mRNA | CTD | PMID:22316170 | bisphenol A | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of ETNK2 mRNA | CTD | PMID:19371625 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ETNK2 mRNA | CTD | PMID:34947998 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of ETNK2 mRNA | CTD | PMID:32145629 | bisphenol A | affects expression | ISO | ETNK2 (Homo sapiens) | 6480464 | bisphenol A affects the expression of ETNK2 mRNA | CTD | PMID:30903817 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of ETNK2 gene | CTD | PMID:28505145 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Genistein] results in increased methylation of ETNK2 gene | CTD | PMID:28505145 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of ETNK2 mRNA | CTD | PMID:25181051 | buspirone | increases expression | EXP | | 6480464 | Buspirone results in increased expression of ETNK2 mRNA | CTD | PMID:24136188 | butanal | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of ETNK2 mRNA | CTD | PMID:26079696 | butyric acid | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Butyric Acid results in increased expression of ETNK2 mRNA | CTD | PMID:34581912 | calcitriol | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of ETNK2 mRNA | CTD | PMID:16002434 | carbon nanotube | decreases expression | ISO | Etnk2 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of ETNK2 mRNA | CTD | PMID:25620056 | chlorpyrifos | increases expression | ISO | Etnk2 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of ETNK2 mRNA | CTD | PMID:32715474 | chlorpyrifos | decreases expression | ISO | Etnk2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of ETNK2 mRNA | CTD | PMID:37019170 | ciguatoxin CTX1B | affects expression | ISO | Etnk2 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of ETNK2 mRNA | CTD | PMID:18353800 | clofibrate | decreases expression | ISO | Etnk2 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of ETNK2 mRNA | CTD | PMID:23811191 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of ETNK2 mRNA | CTD | PMID:24386269 | cyclosporin A | decreases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of ETNK2 mRNA | CTD | PMID:20106945 | dibenzofurans | increases expression | ISO | Etnk2 (Mus musculus) | 6480464 | Dibenzofurans results in increased expression of ETNK2 mRNA | CTD | PMID:34254344 | diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of ETNK2 mRNA | CTD | PMID:36653537 | dimethylarsinic acid | multiple interactions | ISO | Etnk2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of ETNK2 mRNA | CTD | PMID:34876320 | doxorubicin | decreases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of ETNK2 mRNA | CTD | PMID:29803840 | epoxiconazole | decreases expression | ISO | Etnk2 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of ETNK2 mRNA | CTD | PMID:35436446 | fenofibrate | decreases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Fenofibrate results in decreased expression of ETNK2 mRNA | CTD | PMID:25572481 | fipronil | increases expression | EXP | | 6480464 | fipronil results in increased expression of ETNK2 mRNA | CTD | PMID:34044035 | genistein | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Genistein results in increased expression of ETNK2 mRNA | CTD | PMID:19371625 | genistein | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Genistein] results in increased methylation of ETNK2 gene | CTD | PMID:28505145 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of ETNK2 mRNA | CTD | PMID:33387578 | lead(0) | affects expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Lead affects the expression of ETNK2 mRNA | CTD | PMID:28903495 | methylarsonic acid | multiple interactions | ISO | Etnk2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of ETNK2 mRNA | CTD | PMID:34876320 | N-acetyl-1,4-benzoquinone imine | affects response to substance | ISO | ETNK2 (Homo sapiens) | 6480464 | ETNK2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine | CTD | PMID:21177773 | O-methyleugenol | decreases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of ETNK2 mRNA | CTD | PMID:32234424 | paracetamol | affects expression | ISO | Etnk2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of ETNK2 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of ETNK2 mRNA | CTD | PMID:29067470 | parathion | increases expression | ISO | Etnk2 (Mus musculus) | 6480464 | Parathion results in increased expression of ETNK2 mRNA | CTD | PMID:34813904 | pentanal | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | pentanal results in increased expression of ETNK2 mRNA | CTD | PMID:26079696 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Etnk2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ETNK2 mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | ISO | Etnk2 (Mus musculus) | 6480464 | Phenobarbital affects the expression of ETNK2 mRNA | CTD | PMID:23091169 | pirinixic acid | decreases expression | ISO | Etnk2 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of ETNK2 mRNA | CTD | PMID:20813756 and PMID:23811191 | potassium dichromate | increases expression | ISO | Etnk2 (Mus musculus) | 6480464 | Potassium Dichromate results in increased expression of ETNK2 mRNA | CTD | PMID:23608068 | pregnenolone 16alpha-carbonitrile | increases expression | ISO | Etnk2 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in increased expression of ETNK2 mRNA | CTD | PMID:28903501 | propanal | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of ETNK2 mRNA | CTD | PMID:26079696 | resveratrol | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | resveratrol results in increased expression of ETNK2 mRNA | CTD | PMID:19371625 | silicon dioxide | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Silicon Dioxide results in increased expression of ETNK2 mRNA | CTD | PMID:34973136 | sodium arsenate | multiple interactions | ISO | Etnk2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of ETNK2 mRNA | CTD | PMID:34876320 | sodium arsenite | multiple interactions | ISO | Etnk2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of ETNK2 mRNA | CTD | PMID:34876320 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of ETNK2 mRNA | CTD | PMID:19281266 | sulforaphane | decreases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of ETNK2 mRNA | CTD | PMID:31838189 | sunitinib | decreases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of ETNK2 mRNA | CTD | PMID:31533062 | tamoxifen | increases expression | ISO | Etnk2 (Mus musculus) | 6480464 | Tamoxifen results in increased expression of ETNK2 mRNA | CTD | PMID:25123088 | tetrachloromethane | decreases expression | ISO | Etnk2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of ETNK2 mRNA | CTD | PMID:27339419 and PMID:31919559 | tetrachloromethane | increases methylation | EXP | | 6480464 | Carbon Tetrachloride results in increased methylation of ETNK2 promoter | CTD | PMID:30690589 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of ETNK2 mRNA | CTD | PMID:30690589 and PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ETNK2 mRNA] | CTD | PMID:31150632 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of ETNK2 mRNA | CTD | PMID:23411599 | triptonide | increases expression | ISO | Etnk2 (Mus musculus) | 6480464 | triptonide results in increased expression of ETNK2 mRNA | CTD | PMID:33045310 | troglitazone | decreases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | troglitazone results in decreased expression of ETNK2 mRNA | CTD | PMID:25572481 | valproic acid | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of ETNK2 mRNA | CTD | PMID:28001369 and PMID:29154799 | zearalenone | increases expression | ISO | ETNK2 (Homo sapiens) | 6480464 | Zearalenone results in increased expression of ETNK2 mRNA | CTD | PMID:19371625 | |