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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,4-benzoquinone | multiple interactions | ISO | RGD:737004 | 6480464 | benzoquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] | CTD | PMID:7884313 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:10412 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CSF1R mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:10412 | 6480464 | Ethinyl Estradiol results in increased expression of CSF1R mRNA | CTD | PMID:12072388 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:10412 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CSF1R mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:10412 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CSF1R mRNA | CTD | PMID:15034205 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:10412 | 6480464 | Tetrachlorodibenzodioxin affects the expression of CSF1R mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CSF1R mRNA | CTD | PMID:22298810 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:10412 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CSF1R mRNA | CTD | PMID:20188158 | 4-hydroxynon-2-enal | increases expression | ISO | RGD:10412 | 6480464 | 4-hydroxy-2-nonenal results in increased expression of CSF1R mRNA | CTD | PMID:19191707 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:737004 | 6480464 | decitabine inhibits the reaction [Smoke results in decreased expression of CSF1R mRNA] | CTD | PMID:21095227 | all-trans-retinoic acid | multiple interactions | ISO | RGD:737004 | 6480464 | Bucladesine promotes the reaction [Tretinoin results in increased expression of CSF1R mRNA]; more ... | CTD | PMID:8445950 | all-trans-retinoic acid | increases expression | ISO | RGD:737004 | 6480464 | Tretinoin results in increased expression of CSF1R mRNA | CTD | PMID:8445950 | all-trans-retinoic acid | multiple interactions | ISO | RGD:737004 | 6480464 | [LCP2 protein co-treated with CSF1R protein] promotes the reaction [Tretinoin results in increased expression of PXN protein]; more ... | CTD | PMID:16439309 | all-trans-retinoic acid | increases response to substance | ISO | RGD:737004 | 6480464 | CSF1R results in increased susceptibility to Tretinoin | CTD | PMID:9158000 | all-trans-retinoic acid | multiple interactions | ISO | RGD:737004 | 6480464 | CSF1R promotes the reaction [Tretinoin results in decreased phosphorylation of RB1 protein] | CTD | PMID:9158000 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CSF1R mRNA | CTD | PMID:16483693 | benzene | multiple interactions | ISO | RGD:737004 | 6480464 | Benzene promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] | CTD | PMID:7884313 | benzene-1,2,4-triol | multiple interactions | ISO | RGD:737004 | 6480464 | hydroxyhydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] | CTD | PMID:7884313 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of CSF1R protein | CTD | PMID:21467743 | benzo[a]pyrene | decreases expression | ISO | RGD:10412 | 6480464 | Benzo(a)pyrene results in decreased expression of CSF1R mRNA | CTD | PMID:15034205 | bucladesine | multiple interactions | ISO | RGD:737004 | 6480464 | Bucladesine promotes the reaction [Tretinoin results in increased expression of CSF1R mRNA] | CTD | PMID:8445950 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of CSF1R mRNA | CTD | PMID:19167457 | calcitriol | increases expression | ISO | RGD:737004 | 6480464 | Calcitriol results in increased expression of CSF1R mRNA | CTD | PMID:12441127 | calcitriol | increases response to substance | ISO | RGD:737004 | 6480464 | CSF1R results in increased susceptibility to Calcitriol | CTD | PMID:9158000 | calcitriol | multiple interactions | ISO | RGD:737004 | 6480464 | CSF1R promotes the reaction [Calcitriol results in decreased phosphorylation of RB1 protein] | CTD | PMID:9158000 | curcumin | multiple interactions | ISO | RGD:737004 | 6480464 | Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein] | CTD | PMID:15129424 | curcumin | increases expression | ISO | RGD:10412 | 6480464 | Curcumin results in increased expression of CSF1R mRNA | CTD | PMID:22714040 | D-gluconic acid | multiple interactions | EXP | | 6480464 | [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of CSF1R mRNA | CTD | PMID:16556975 | deoxycholic acid | multiple interactions | EXP | | 6480464 | [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of CSF1R mRNA | CTD | PMID:16556975 | dexamethasone | increases expression | ISO | RGD:737004 | 6480464 | Dexamethasone results in increased expression of CSF1R protein | CTD | PMID:15679045 | dexamethasone | increases expression | ISO | RGD:10412 | 6480464 | Dexamethasone results in increased expression of CSF1R mRNA | CTD | PMID:21041162 | dichlorine | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] affects the expression of CSF1R mRNA | CTD | PMID:18636392 | diethylstilbestrol | increases expression | ISO | RGD:10412 | 6480464 | Diethylstilbestrol results in increased expression of CSF1R mRNA | CTD | PMID:21041162 | dimethyl sulfoxide | increases expression | ISO | RGD:737004 | 6480464 | Dimethyl Sulfoxide results in increased expression of CSF1R mRNA | CTD | PMID:8445950 | fenofibrate | decreases expression | EXP | | 6480464 | Fenofibrate results in decreased expression of CSF1R mRNA | CTD | PMID:16707586 | hydrogen peroxide | affects expression | ISO | RGD:737004 | 6480464 | Hydrogen Peroxide affects the expression of CSF1R mRNA | CTD | PMID:20044591 | hydroquinone | multiple interactions | ISO | RGD:737004 | 6480464 | hydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] | CTD | PMID:7884313 | imatinib | decreases expression | EXP | | 6480464 | imatinib results in decreased expression of CSF1R mRNA | CTD | PMID:19242505 | isotretinoin | increases expression | ISO | RGD:737004 | 6480464 | Isotretinoin results in increased expression of CSF1R mRNA | CTD | PMID:20436886 | lead diacetate | affects expression | ISO | RGD:10412 | 6480464 | lead acetate affects the expression of CSF1R mRNA | CTD | PMID:21829687 | methotrexate | decreases expression | ISO | RGD:737004 | 6480464 | Methotrexate results in decreased expression of CSF1R mRNA | CTD | PMID:17400583 | nitric oxide | multiple interactions | ISO | RGD:737004 | 6480464 | benzoquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; more ... | CTD | PMID:7884313 | ozone | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] affects the expression of CSF1R mRNA | CTD | PMID:18636392 | paraquat | affects expression | EXP | | 6480464 | Paraquat affects the expression of CSF1R mRNA | CTD | PMID:15206577 | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of CSF1R mRNA | CTD | PMID:17077588 PMID:18198484 | paraquat | increases expression | ISO | RGD:10412 | 6480464 | Paraquat results in increased expression of CSF1R mRNA | CTD | PMID:21371552 | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of CSF1R mRNA | CTD | PMID:17077588 | phenobarbital | multiple interactions | ISO | RGD:10412 | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CSF1R mRNA] | CTD | PMID:19482888 | phenobarbital | decreases expression | ISO | RGD:10412 | 6480464 | Phenobarbital results in decreased expression of CSF1R mRNA | CTD | PMID:19482888 | pirinixic acid | decreases expression | ISO | RGD:10412 | 6480464 | pirinixic acid results in decreased expression of CSF1R mRNA | CTD | PMID:17426115 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of CSF1R mRNA | CTD | PMID:16707586 | resveratrol | multiple interactions | ISO | RGD:737004 | 6480464 | [resveratrol co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CSF1R mRNA | CTD | PMID:16267019 | resveratrol | multiple interactions | ISO | RGD:10412 | 6480464 | resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of CSF1R protein] | CTD | PMID:22118570 | tamoxifen | multiple interactions | EXP | | 6480464 | [bexarotene co-treated with Tamoxifen] results in decreased expression of CSF1R mRNA | CTD | PMID:17630414 | testosterone | decreases expression | ISO | RGD:10412 | 6480464 | Testosterone results in decreased expression of CSF1R mRNA | CTD | PMID:15788153 | tocopherol | increases expression | ISO | RGD:10412 | 6480464 | Tocopherols results in increased expression of CSF1R mRNA | CTD | PMID:17056531 | trans-resveratrol | multiple interactions | ISO | RGD:737004 | 6480464 | [resveratrol co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CSF1R mRNA | CTD | PMID:16267019 | trans-resveratrol | multiple interactions | ISO | RGD:10412 | 6480464 | resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of CSF1R protein] | CTD | PMID:22118570 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Cytokine-cytokine receptor interaction |
| Endocytosis | |
| Hematopoietic cell lineage | |
| Osteoclast differentiation | |
| Pathways in cancer | |
| PI3K-Akt signaling pathway | |
| Transcriptional misregulation in cancer | |
| Pathway Interaction Database | C-MYB transcription factor network (PID:200153) |
| Integrins in angiogenesis (PID:200128) | |
| Signaling events mediated by PTP1B (PID:200042) | |
| Signaling events mediated by TCPTP (PID:200078) | |
References - curated| 1. |
Borycki AG, etal., Growth Factors 1992;6(3):209-18. |
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Borycki AG, etal., Growth Factors 1992;6(3):209-18. |
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GOA data from the GO Consortium |
| 4. |
Hammes LS, etal., Gynecol Oncol. 2008 Jun 18. |
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Ide H, etal., Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14404-9. Epub 2002 Oct 15. |
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Kluger HM, etal., Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):173-7. |
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MGD data from the GO Consortium |
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NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
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Ohno H, etal., Mol Cancer Ther. 2006 Nov;5(11):2634-43. |
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Online Mendelian Inheritance in Man, OMIM (TM). |
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Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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RGD automated data pipeline |
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RGD automated import pipeline for gene-chemical interactions |
| 14. |
RGD comprehensive gene curation |
| 15. |
Richardsen E, etal., Histopathology. 2008 May 28;. |
| 16. |
Shadduck RK, etal., Exp Hematol. 1996 Feb;24(2):314-7. |
| 17. |
Toma MI, etal., Neoplasia. 2008 Jul;10(7):634-42. |
References - uncurated
RGD Disease Portals| Csf1r has been annotated in the following RGD Disease Portals. |
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Candidate Gene Status
Comparative Map Data| Csf1r (Rattus norvegicus) |
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| CSF1R (Homo sapiens) |
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| Csf1r (Mus musculus) |
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Position Markers| D18Mit140 |
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| BI288375 |
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| RH131310 |
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| BI283816 |
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| MARC_12115-12116:1004707389:1 |
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| Csf1r |
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| PMC219482P2 |
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| CSF1R_1770 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001029901 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06095430 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06095431 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095452 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095453 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095454 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC107475 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473971 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X61479 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001029901 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001025072 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001025072 | (Get FASTA) |
| GenBank Protein | AAI07476 | (Get FASTA) |
| CAA43706 | (Get FASTA) | |
| EDM14588 | (Get FASTA) | |
| Q00495 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000018414 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000040411 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000049357 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 307403 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 3817 | ENTREZGENE |
| InterPro | Ig-like | UniProtKB/Swiss-Prot |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| Ig_I-set | UniProtKB/Swiss-Prot | |
| Ig_sub | UniProtKB/Swiss-Prot | |
| Ig_sub2 | UniProtKB/Swiss-Prot | |
| Immunoglobulin | UniProtKB/TrEMBL | |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser-Thr/Tyr-Pkinase | UniProtKB/Swiss-Prot | |
| Tyr_Pkinase_cat_dom | UniProtKB/Swiss-Prot | |
| Tyr_prot_kinase_AS | UniProtKB/Swiss-Prot | |
| Tyr_prot_kinase_CSF1/PDGF_rcpt | UniProtKB/Swiss-Prot | |
| Tyr_prot_kinase_rcpt_3_CS | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:307403 | ENTREZGENE |
| Pfam | I-set | UniProtKB/Swiss-Prot |
| PF00047 | UniProtKB/TrEMBL | |
| Pkinase_Tyr | UniProtKB/Swiss-Prot | |
| PharmGKB | CSF1R | RGD |
| PIRSF | TyrPK_CSF1-R | UniProtKB/Swiss-Prot |
| PROSITE | IG_LIKE | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_TYR | UniProtKB/Swiss-Prot | |
| RECEPTOR_TYR_KIN_III | UniProtKB/Swiss-Prot | |
| SMART | IGc2 | UniProtKB/Swiss-Prot |
| SM00409 | UniProtKB/Swiss-Prot | |
| TyrKc | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| UniGene | Rn.72599 | ENTREZGENE |
| UniProt | CSF1R_RAT | UniProtKB/Swiss-Prot |
| D4ACA7_RAT | UniProtKB/TrEMBL | |
| Q3B7T5_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2002-06-10 | Csf1r | Colony stimulating factor 1 receptor | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
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| gene_regulation | transcriptionally active only in undifferentiated myoblasts | 727559 |
| More on Csf1r | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2425 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




