Gene: Ptgs1 (prostaglandin-endoperoxide synthase 1) Rattus norvegicus
Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Description: ENCODES a protein that exhibits lipid binding; prostaglandin-endoperoxide synthase activity (ortholog); INVOLVED IN aging; learning; maintenance of blood-brain barrier; PARTICIPATES IN cyclooxygenase mediated pathway of arachidonic acid metabolism; paracetamol drug pathway; prostanoid biosynthetic pathway; ASSOCIATED WITH Alzheimer Disease; Anaphylaxis; Arthritis, Experimental; FOUND IN cytoplasm; nuclear envelope; intracellular membrane-bounded organelle (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2-arachidonoylglycerol; 4-hydroxyphenyl retinamide
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: COX-1; Cox-3; Cox1; Cox3; cyclooxygenase 1; cyclooxygenase 3; cyclooxygenase-1; PGH synthase 1; PGHS-1; PHS 1; prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; prostaglandin H2 synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Latest Assembly: RGSC Genome Assembly v3.4
Rat Cytogenetic Map3p11 NCBI
RGSC Genome Assembly v5.0320,869,915 - 20,891,512+NCBI
RGSC Genome Assembly v3.4315,343,832 - 15,365,412+NCBI
Rat Celera Assembly314,295,843 - 14,317,389+NCBI
Genome Assembly 3.1315,240,203 - 15,261,784+NCBI

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (RGSC Genome Assembly v3.4)


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
More on Ptgs1
Entrez Gene
Ensembl Gene
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Vista + UCSC

RGD Object Information
RGD ID: 3439
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2014-07-22
Status: ACTIVE