| (+)-artemisinin | increases expression | ISO | RGD:1352962 | 6480464 | artemisinine results in increased expression of CYP3A4 mRNA | CTD | PMID:15761118 PMID:18332078 |
| (+)-artemisinin | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of artemisinine | CTD | PMID:12920490 |
| (+)-artemisinin | multiple interactions | ISO | RGD:1352962 | 6480464 | [artemisinine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:17041008 |
| (+)-artemisinin | increases expression | ISO | RGD:1352962 | 6480464 | artemisinine results in increased expression of CYP3A4 mRNA | CTD | PMID:18332078 PMID:15761118 |
| (+)-trans-(S)-allethrin | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of bioallethrin | CTD | PMID:19249324 |
| (+)-trans-(S)-allethrin | increases expression | ISO | RGD:1352962 | 6480464 | bioallethrin results in increased expression of CYP3A4 mRNA | CTD | PMID:19249324 |
| (3S,5R)-fluvastatin | multiple interactions | ISO | RGD:1352962 | 6480464 | fluvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam] | CTD | PMID:16029222 |
| (3S,5R)-fluvastatin | decreases activity | ISO | RGD:1352962 | 6480464 | fluvastatin results in decreased activity of CYP3A4 protein | CTD | PMID:16029222 |
| (E)-roxithromycin | multiple interactions | ISO | RGD:1352962 | 6480464 | Roxithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | CTD | PMID:16416302 |
| (E)-roxithromycin | decreases activity | ISO | RGD:1352962 | 6480464 | Roxithromycin results in decreased activity of CYP3A4 protein | CTD | PMID:16416302 PMID:17164692 |
| (E)-roxithromycin | decreases expression | ISO | RGD:1352962 | 6480464 | Roxithromycin results in decreased expression of CYP3A4 mRNA | CTD | PMID:16837568 |
| (E)-roxithromycin | decreases activity | ISO | RGD:1352962 | 6480464 | Roxithromycin results in decreased activity of CYP3A4 protein | CTD | PMID:17164692 PMID:16416302 |
| (S)-colchicine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Colchicine | CTD | PMID:15914514 PMID:16007523 |
| (S)-naringenin | decreases activity | ISO | RGD:1352962 | 6480464 | naringenin results in decreased activity of CYP3A4 protein | CTD | PMID:21053930 |
| (S)-nicotine | multiple interactions | ISO | RGD:1352962 | 6480464 | [Nicotine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | CTD | PMID:12851153 |
| (S)-nicotine | multiple interactions | ISO | RGD:1352962 | 6480464 | [Nicotine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | CTD | PMID:12851153 PMID:12851153 |
| 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane | multiple interactions | ISO | RGD:1619215 | 6480464 | [ESR1 protein co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of CYP3A41A mRNA; more ... | CTD | PMID:21252393 |
| 1,2,3,5-tetrachlorobenzene | increases oxidation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased oxidation of 1,2,3,5-tetrachlorobenzene | CTD | PMID:7747284 |
| 1,2-dichloroethene | decreases activity | EXP | | 6480464 | 1,2-dichloroethylene results in decreased activity of CYP3A2 protein | CTD | PMID:9493318 |
| 1,2-dichloroethene | decreases expression | EXP | | 6480464 | 1,2-dichloroethylene results in decreased expression of CYP3A2 protein | CTD | PMID:9493318 |
| 1,2-dilauroyl-sn-glycero-3-phosphocholine | multiple interactions | ISO | RGD:1352962 | 6480464 | [1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A4 protein | CTD | PMID:1627548 |
| 1,2-dilauroyl-sn-glycero-3-phosphocholine | multiple interactions | EXP | | 6480464 | [1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A2 protein | CTD | PMID:1627548 |
| 1,4-dichlorobenzene | increases oxidation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased oxidation of 4-dichlorobenzene | CTD | PMID:9817075 |
| 1,4-naphthoquinone | increases expression | ISO | RGD:1352962 | 6480464 | 1,4-naphthoquinone results in increased expression of CYP3A4 mRNA | CTD | PMID:18602459 |
| 1,4-naphthoquinone | increases abundance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased abundance of 1,4-naphthoquinone | CTD | PMID:16243959 |
| 1,8-cineole | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of cineole | CTD | PMID:15715982 |
| 1-(3-chlorophenyl)piperazine | multiple interactions | ISO | RGD:1352962 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [1-(3-chlorophenyl)piperazine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] | CTD | PMID:21402137 |
| 1-naphthol | increases abundance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased abundance of 1-naphthol | CTD | PMID:16243959 |
| 13-cis-retinal | multiple interactions | ISO | RGD:1352962 | 6480464 | 13-cis-retinal promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | CTD | PMID:16632523 |
| 13-cis-retinal | increases activity | ISO | RGD:1352962 | 6480464 | 13-cis-retinal results in increased activity of CYP3A4 protein | CTD | PMID:16632523 |
| 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of CYP3A2 mRNA | CTD | PMID:15953391 |
| 17alpha-ethynylestradiol | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Ethinyl Estradiol | CTD | PMID:15304426 PMID:15554232 |
| 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1352962 | 6480464 | Ethinyl Estradiol binds to and results in decreased activity of CYP3A4 protein; more ... | CTD | PMID:11907170 |
| 17alpha-ethynylestradiol | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Ethinyl Estradiol | CTD | PMID:15286053 |
| 17alpha-ethynylestradiol | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Ethinyl Estradiol | CTD | PMID:15554232 PMID:15304426 |
| 17alpha-ethynylestradiol | affects hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the hydroxylation of Ethinyl Estradiol | CTD | PMID:2271712 |
| 17beta-estradiol | multiple interactions | ISO | RGD:1352962 | 6480464 | Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol]; more ... | CTD | PMID:16790556 |
| 17beta-estradiol | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Estradiol | CTD | PMID:9047321 PMID:9714305 |
| 17beta-estradiol | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 promoter mutant form inhibits the reaction [Estradiol results in increased expression of CYP3A4 mRNA] | CTD | PMID:12505310 PMID:12505310 |
| 17beta-estradiol | increases expression | ISO | RGD:1352962 | 6480464 | Estradiol results in increased expression of CYP3A4 mRNA | CTD | PMID:12505310 PMID:15650019 |
| 17beta-estradiol | increases expression | ISO | RGD:1352962 | 6480464 | Estradiol results in increased expression of CYP3A4 protein | CTD | PMID:15650019 |
| 17beta-estradiol | increases expression | ISO | RGD:1352962 | 6480464 | Estradiol results in increased expression of CYP3A4 mRNA | CTD | PMID:15650019 PMID:12505310 |
| 17beta-estradiol | affects binding | ISO | RGD:1352962 | 6480464 | Estradiol binds to CYP3A4 protein | CTD | PMID:9047321 |
| 17beta-estradiol | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Estradiol | CTD | PMID:16790556 |
| 17beta-estradiol | affects hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the hydroxylation of Estradiol | CTD | PMID:2271712 |
| 17beta-estradiol | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Estradiol | CTD | PMID:9714305 PMID:9047321 |
| 17beta-estradiol | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 promoter mutant form inhibits the reaction [Estradiol results in increased expression of CYP3A4 mRNA] | CTD | PMID:12505310 |
| 1H-pyrazole | decreases expression | ISO | RGD:1619215 | 6480464 | pyrazole results in decreased expression of CYP3A41A mRNA | CTD | PMID:17945193 |
| 2'-deoxyguanosine | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; more ... | CTD | PMID:21907773 |
| 2,2',4,4',5,5'-hexachlorobiphenyl | increases expression | ISO | RGD:1352962 | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of CYP3A4 mRNA | CTD | PMID:22664347 |
| 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CYP3A2 mRNA | CTD | PMID:18796159 |
| 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1352962 | 6480464 | Tetrachlorodibenzodioxin affects the expression of CYP3A4 mRNA | CTD | PMID:22298810 |
| 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CYP3A2 mRNA | CTD | PMID:18796159 PMID:21215274 |
| 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1619215 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CYP3A41A mRNA | CTD | PMID:19770486 |
| 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1352962 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CYP3A4 mRNA | CTD | PMID:16985168 |
| 2,4,6-trinitrobenzenesulfonic acid | multiple interactions | EXP | | 6480464 | Polymyxin B inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein]; more ... | CTD | PMID:18079364 |
| 2,6-di-tert-butyl-4-methylphenol | increases expression | ISO | RGD:1352962 | 6480464 | Butylated Hydroxytoluene results in increased expression of CYP3A4 mRNA | CTD | PMID:18570159 |
| 2-acetamidofluorene | increases expression | EXP | | 6480464 | 2-Acetylaminofluorene results in increased expression of CYP3A2 protein | CTD | PMID:10445401 |
| 2-hydroxy-17beta-estradiol | increases chemical synthesis | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol | CTD | PMID:16790556 |
| 2-hydroxy-17beta-estradiol | multiple interactions | ISO | RGD:1352962 | 6480464 | decamethrin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol]; more ... | CTD | PMID:16790556 |
| 2-naphthol | increases abundance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased abundance of 2-naphthol | CTD | PMID:16243959 |
| 3,3'-diindolylmethane | decreases activity | ISO | RGD:1352962 | 6480464 | 3,3'-diindolylmethane results in decreased activity of CYP3A4 protein | CTD | PMID:19770484 |
| 3,4-methylenedioxymethamphetamine | multiple interactions | ISO | RGD:1352962 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [1-(3-chlorophenyl)piperazine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; more ... | CTD | PMID:21402137 |
| 3-methylcholanthrene | multiple interactions | EXP | | 6480464 | Dactinomycin inhibits the reaction [Methylcholanthrene results in increased expression of CYP3A2 mRNA] | CTD | PMID:11181506 |
| 3-methylcholanthrene | decreases expression | ISO | RGD:1352962 | 6480464 | Methylcholanthrene results in decreased expression of CYP3A4 protein | CTD | PMID:10640517 |
| 3-methylcholanthrene | increases expression | EXP | | 6480464 | Methylcholanthrene results in increased expression of CYP3A2 mRNA | CTD | PMID:11181506 |
| 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in decreased expression of CYP3A2 mRNA | CTD | PMID:19162173 |
| 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | CTD | PMID:9029045 |
| 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | CTD | PMID:11774366 |
| 4-hydroxynon-2-enal | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal; more ... | CTD | PMID:21766881 |
| 4-hydroxyphenyl retinamide | multiple interactions | ISO | RGD:1352962 | 6480464 | Fenretinide promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | CTD | PMID:16632523 |
| 5,7-dihydroxy-4'-methoxyflavone | multiple interactions | ISO | RGD:1352962 | 6480464 | acacetin binds to and results in decreased activity of CYP3A4 protein; more ... | CTD | PMID:21053930 |
| 5-fluorouracil | affects expression | ISO | RGD:1352962 | 6480464 | Fluorouracil affects the expression of CYP3A4 mRNA | CTD | PMID:16584549 |
| 6alpha-methylprednisolone | increases activity | ISO | RGD:1352962 | 6480464 | Methylprednisolone results in increased activity of CYP3A4 protein | CTD | PMID:15964336 |
| 6alpha-methylprednisolone | decreases expression | ISO | RGD:1352962 | 6480464 | Methylprednisolone results in decreased expression of CYP3A4 mRNA | CTD | PMID:16837568 |
| 6beta-hydroxytestosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone | CTD | PMID:19135037 |
| 6beta-hydroxytestosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | fipronil promotes the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone] | CTD | PMID:17084830 |
| 6beta-hydroxytestosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone | CTD | PMID:17084830 PMID:19135037 |
| 6beta-hydroxytestosterone | increases chemical synthesis | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone | CTD | PMID:12401345 |
| 7,12-dimethyltetraphene | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene | CTD | PMID:20507880 |
| 9-cis-retinoic acid | multiple interactions | ISO | RGD:1352962 | 6480464 | alitretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | CTD | PMID:16632523 |
| 9-cis-retinoic acid | multiple interactions | ISO | RGD:1352962 | 6480464 | alitretinoin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; more ... | CTD | PMID:19686701 |
| 9-cis-retinoic acid | increases activity | ISO | RGD:1352962 | 6480464 | alitretinoin results in increased activity of CYP3A4 protein | CTD | PMID:16632523 |
| acephate | multiple interactions | ISO | | 6480464 | [acephate co-treated with vinclozolin] affects the expression of CYP3A2 protein; more ... | CTD | PMID:17686559 |
| acephate | multiple interactions | ISO | RGD:1619215 | 6480464 | [acephate co-treated with vinclozolin] affects the expression of CYP3A2 protein; more ... | CTD | PMID:17686559 |
| acetochlor | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of acetochlor | CTD | PMID:11133395 |
| aconitine | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Aconitine | CTD | PMID:21277363 |
| aconitine | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of Aconitine] which results in increased chemical synthesis of 16-O-demethylaconitine | CTD | PMID:21277363 |
| actinomycin D | multiple interactions | EXP | | 6480464 | Dactinomycin inhibits the reaction [Methylcholanthrene results in increased expression of CYP3A2 mRNA]; more ... | CTD | PMID:11181506 |
| actinomycin D | multiple interactions | ISO | RGD:1352962 | 6480464 | Dactinomycin inhibits the reaction [o,p'-DDT results in increased expression of CYP3A4 mRNA] | CTD | PMID:15795092 |
| adinazolam | multiple interactions | ISO | RGD:1352962 | 6480464 | Troleandomycin inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam]; more ... | CTD | PMID:9600717 |
| adinazolam | decreases methylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased methylation of adinazolam | CTD | PMID:9600717 |
| afimoxifene | decreases activity | ISO | RGD:1352962 | 6480464 | 4-hydroxytamoxifen results in decreased activity of CYP3A4 protein | CTD | PMID:12419016 |
| afimoxifene | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 4-hydroxytamoxifen | CTD | PMID:20507880 |
| aflatoxin B1 | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin B1-2,3-oxide; more ... | CTD | PMID:20707407 |
| aflatoxin B1 | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Aflatoxin B1 | CTD | PMID:20707407 |
| aflatoxin B1 | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] | CTD | PMID:21907773 |
| aflatoxin B1 | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein promotes the reaction [Aflatoxin B1 results in increased activity of TP53 protein] | CTD | PMID:20655369 |
| aflatoxin B1 | increases expression | ISO | RGD:1352962 | 6480464 | Aflatoxin B1 results in increased expression of CYP3A4 mRNA | CTD | PMID:21641981 PMID:21994236 |
| aflatoxin B1 | decreases expression | ISO | RGD:1352962 | 6480464 | Aflatoxin B1 results in decreased expression of CYP3A4 mRNA | CTD | PMID:22100608 |
| aflatoxin B1 | multiple interactions | ISO | RGD:1352962 | 6480464 | Aflatoxin B1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter] | CTD | PMID:21641981 |
| aflatoxin B1 | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased susceptibility to Aflatoxin B1 | CTD | PMID:11189750 |
| aflatoxin B1 | increases activity | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased activity of Aflatoxin B1 | CTD | PMID:15988000 |
| aflatoxin B1 | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Aflatoxin B1 | CTD | PMID:2271712 PMID:2655891 |
| aflatoxin B1 | affects expression | ISO | RGD:1352962 | 6480464 | Aflatoxin B1 affects the expression of CYP3A4 protein | CTD | PMID:20106945 |
| aflatoxin B1 | increases activity | EXP | | 6480464 | CYP3A2 protein results in increased activity of Aflatoxin B1 | CTD | PMID:11346484 |
| aflatoxin B1 exo-8,9-epoxide | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin B1-2,3-oxide | CTD | PMID:20707407 |
| alachlor | increases expression | ISO | RGD:1352962 | 6480464 | alachlor results in increased expression of CYP3A4 mRNA | CTD | PMID:16565514 |
| alachlor | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of alachlor | CTD | PMID:10475613 |
| albendazole | multiple interactions | EXP | | 6480464 | [SOD2 co-treated with CYP3A4] affects the susceptibility to Albendazole | CTD | PMID:19501153 |
| alfentanil | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Alfentanil | CTD | PMID:15731592 PMID:15557344 |
| alfentanil | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Alfentanil | CTD | PMID:15557344 PMID:15731592 |
| alfentanil | multiple interactions | ISO | RGD:1352962 | 6480464 | CYB5 protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil] | CTD | PMID:15557344 |
| all-trans-retinoic acid | multiple interactions | ISO | RGD:1352962 | 6480464 | Tretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | CTD | PMID:16632523 |
| all-trans-retinoic acid | decreases activity | ISO | RGD:1352962 | 6480464 | Tretinoin results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| all-trans-retinoic acid | decreases expression | ISO | RGD:1352962 | 6480464 | Tretinoin results in decreased expression of CYP3A4 mRNA | CTD | PMID:16985168 |
| all-trans-retinoic acid | increases activity | ISO | RGD:1352962 | 6480464 | Tretinoin results in increased activity of CYP3A4 protein | CTD | PMID:16632523 |
| allyl alcohol | decreases expression | EXP | | 6480464 | allyl alcohol results in decreased expression of CYP3A2 protein | CTD | PMID:10445401 |
| almotriptan | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of almotriptan | CTD | PMID:12642466 |
| almotriptan | decreases methylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased methylation of almotriptan | CTD | PMID:12642466 |
| alpha-hexachlorocyclohexane | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of CYP3A2 mRNA; more ... | CTD | PMID:16246485 |
| alpha-hexachlorocyclohexane | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 protein | CTD | PMID:16246485 PMID:11165752 |
| alpha-hexachlorocyclohexane | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 protein | CTD | PMID:11165752 PMID:16246485 |
| alpha-hexachlorocyclohexane | increases expression | EXP | | 6480464 | alpha-hexachlorocyclohexane results in increased expression of CYP3A2 mRNA | CTD | PMID:16940010 |
| alpha-hexachlorocyclohexane | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP3A2 protein | CTD | PMID:11165752 |
| alpha-linolenic acid | decreases activity | ISO | RGD:1352962 | 6480464 | alpha-Linolenic Acid results in decreased activity of CYP3A4 protein | CTD | PMID:16978661 |
| alpha-tocotrienol | increases expression | ISO | RGD:1352962 | 6480464 | tocotrienol, alpha results in increased expression of CYP3A4 | CTD | PMID:15269186 |
| alprazolam | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Alprazolam | CTD | PMID:16042670 PMID:12196913 |
| alprazolam | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Alprazolam | CTD | PMID:12196913 PMID:16042670 |
| alprazolam | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein binds to and affects the metabolism of Alprazolam | CTD | PMID:15856409 |
| amiodarone | decreases activity | ISO | RGD:1352962 | 6480464 | Amiodarone results in decreased activity of CYP3A4 protein | CTD | PMID:16449812 PMID:15304522 |
| amiodarone | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Amiodarone | CTD | PMID:15869686 more ... |
| amiodarone | decreases activity | ISO | RGD:1352962 | 6480464 | Amiodarone results in decreased activity of CYP3A4 protein | CTD | PMID:15304522 more ... |
| amiodarone | multiple interactions | ISO | RGD:1352962 | 6480464 | Amiodarone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; more ... | CTD | PMID:22652334 |
| amiodarone | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Amiodarone | CTD | PMID:16449812 more ... |
| amiodarone | decreases activity | ISO | RGD:1352962 | 6480464 | Amiodarone results in decreased activity of CYP3A4 protein | CTD | PMID:15304522 PMID:16449812 |
| amiodarone | multiple interactions | ISO | RGD:1352962 | 6480464 | Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Amiodarone] | CTD | PMID:15869686 |
| amiodarone | increases expression | EXP | | 6480464 | Amiodarone results in increased expression of CYP3A4 mRNA | CTD | PMID:19224547 |
| amiodarone | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased susceptibility to Amiodarone | CTD | PMID:21540358 |
| amiodarone | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Amiodarone | CTD | PMID:8445979 more ... |
| amiodarone | decreases ethylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased ethylation of Amiodarone | CTD | PMID:7905403 |
| amitriptyline | increases metabolic processing | ISO | RGD:1352962 | 6480464 | Amitriptyline results in increased metabolism of CYP3A4 protein | CTD | PMID:18359012 |
| ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CYP3A2 mRNA | CTD | PMID:16483693 |
| amoxapine | increases chemical synthesis | ISO | RGD:1352962 | 6480464 | CYP3A4 results in increased chemical synthesis of Amoxapine | CTD | PMID:21826677 |
| amphetamine | affects chemical synthesis | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the chemical synthesis of Amphetamine | CTD | PMID:15294457 |
| amphetamine | multiple interactions | ISO | RGD:1352962 | 6480464 | Amphetamine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; more ... | CTD | PMID:21402137 |
| amprenavir | decreases activity | ISO | RGD:1352962 | 6480464 | amprenavir results in decreased activity of CYP3A4 protein | CTD | PMID:15523003 |
| andrographolide | decreases expression | ISO | RGD:1352962 | 6480464 | andrographolide results in decreased expression of CYP3A4 mRNA | CTD | PMID:19041297 |
| aniline | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of [norharman co-treated with aniline] | CTD | PMID:15279827 |
| apigenin | decreases activity | ISO | RGD:1352962 | 6480464 | Apigenin results in decreased activity of CYP3A4 protein | CTD | PMID:21053930 |
| apigenin | multiple interactions | ISO | RGD:1352962 | 6480464 | Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; more ... | CTD | PMID:21053930 |
| arachidonic acid | decreases activity | ISO | RGD:1352962 | 6480464 | Arachidonic Acid results in decreased activity of CYP3A4 protein | CTD | PMID:16978661 |
| Aroclor 1254 | increases expression | ISO | RGD:1352962 | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of CYP3A4 mRNA | CTD | PMID:17851650 |
| Aroclor 1254 | increases expression | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of CYP3A2 mRNA | CTD | PMID:22659317 |
| arsenic atom | decreases activity | EXP | | 6480464 | Arsenic results in decreased activity of CYP3A4 protein | CTD | PMID:19932728 |
| arsenic atom | multiple interactions | EXP | | 6480464 | Arsenic inhibits the reaction [Acetaminophen results in increased activity of CYP3A4 protein] | CTD | PMID:19932728 |
| arsenite(3-) | multiple interactions | EXP | | 6480464 | arsenite inhibits the reaction [Rifampin results in increased expression of and results in increased activity of CYP3A2 protein]; more ... | CTD | PMID:22159698 |
| astemizole | increases degradation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased degradation of Astemizole | CTD | PMID:15684493 |
| atrazine | increases expression | ISO | RGD:1352962 | 6480464 | Atrazine results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| atrazine | multiple interactions | ISO | RGD:1352962 | 6480464 | [Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP3A4 protein | CTD | PMID:22515965 |
| atrazine | increases activity | ISO | RGD:1352962 | 6480464 | Atrazine results in increased activity of CYP3A4 protein | CTD | PMID:22310298 |
| azithromycin | multiple interactions | ISO | RGD:1352962 | 6480464 | Azithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | CTD | PMID:16416302 |
| azithromycin | decreases activity | ISO | RGD:1352962 | 6480464 | Azithromycin results in decreased activity of CYP3A4 protein | CTD | PMID:16416302 |
| baicalein | decreases activity | ISO | RGD:1352962 | 6480464 | baicalein results in decreased activity of CYP3A4 protein | CTD | PMID:21053930 |
| benfuracarb | increases activity | ISO | RGD:1352962 | 6480464 | benfuracarb results in increased activity of CYP3A4 protein | CTD | PMID:22310298 |
| benfuracarb | increases expression | ISO | RGD:1352962 | 6480464 | benfuracarb results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| benzo[a]pyrene | increases expression | ISO | RGD:1352962 | 6480464 | Benzo(a)pyrene results in increased expression of CYP3A4 mRNA | CTD | PMID:16545412 |
| benzo[a]pyrene | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of Benzo(a)pyrene] which results in increased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol | CTD | PMID:2509067 |
| benzo[a]pyrene | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Benzo(a)pyrene | CTD | PMID:2509067 |
| benzo[a]pyrene | increases expression | ISO | RGD:1619215 | 6480464 | Benzo(a)pyrene results in increased expression of CYP3A41A mRNA | CTD | PMID:20127859 |
| benzyl isothiocyanate | decreases activity | EXP | | 6480464 | benzyl isothiocyanate results in decreased activity of CYP3A2 protein | CTD | PMID:22664424 |
| benzyl isothiocyanate | decreases expression | EXP | | 6480464 | benzyl isothiocyanate results in decreased expression of CYP3A2 mRNA | CTD | PMID:22664424 |
| bepridil | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Bepridil | CTD | PMID:15286053 |
| beta-carboline | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of [norharman co-treated with aniline] | CTD | PMID:15279827 |
| beta-carotene | multiple interactions | ISO | RGD:1352962 | 6480464 | beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | CTD | PMID:16632523 |
| beta-tocotrienol | increases expression | ISO | RGD:1352962 | 6480464 | tocotrienol, beta results in increased expression of CYP3A4 | CTD | PMID:15269186 |
| bifenthrin | increases expression | ISO | RGD:1352962 | 6480464 | bifenthrin results in increased expression of CYP3A4 mRNA | CTD | PMID:19249324 |
| bilirubin | increases expression | ISO | RGD:1352962 | 6480464 | Bilirubin results in increased expression of CYP3A4 mRNA | CTD | PMID:15382119 |
| bilirubin | multiple interactions | ISO | RGD:1352962 | 6480464 | IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP3A4 mRNA] | CTD | PMID:15382119 |
| bioresmethrin | increases expression | ISO | RGD:1352962 | 6480464 | bioresmethrin results in increased expression of CYP3A4 mRNA | CTD | PMID:19249324 |
| bis(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in increased expression of CYP3A2 mRNA | CTD | PMID:19850644 |
| bis(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:1352962 | 6480464 | [Dexamethasone co-treated with Diethylhexyl Phthalate] results in increased expression of CYP3A4 protein; more ... | CTD | PMID:18332045 |
| bis(2-ethylhexyl) phthalate | increases activity | ISO | RGD:1352962 | 6480464 | Diethylhexyl Phthalate results in increased activity of CYP3A4 protein | CTD | PMID:21742782 |
| bis(2-ethylhexyl) phthalate | increases expression | ISO | RGD:1619215 | 6480464 | Diethylhexyl Phthalate results in increased expression of CYP3A41A mRNA | CTD | PMID:19850644 |
| bis(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:1352962 | 6480464 | Diethylhexyl Phthalate promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | CTD | PMID:11581012 |
| bisphenol A | increases expression | ISO | RGD:1352962 | 6480464 | bisphenol A results in increased expression of CYP3A4 mRNA | CTD | PMID:15650019 PMID:22214767 |
| bisphenol A | increases activity | ISO | RGD:1352962 | 6480464 | bisphenol A results in increased activity of CYP3A4 protein | CTD | PMID:23384967 |
| bisphenol A | increases expression | ISO | RGD:1352962 | 6480464 | bisphenol A results in increased expression of CYP3A4 mRNA | CTD | PMID:15650019 more ... |
| bisphenol A | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone | CTD | PMID:21402134 |
| bisphenol A | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of bisphenol A | CTD | PMID:21402134 |
| bisphenol A | increases expression | ISO | RGD:1352962 | 6480464 | bisphenol A results in increased expression of CYP3A4 mRNA; more ... | CTD | PMID:15650019 |
| bisphenol A | multiple interactions | ISO | RGD:1352962 | 6480464 | [bisphenol A binds to CYP3A4 promoter] which results in decreased expression of CYP3A4 mRNA | CTD | PMID:12851153 |
| bisphenol A | multiple interactions | ISO | RGD:1352962 | 6480464 | bisphenol A promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | CTD | PMID:11581012 |
| bisphenol A | multiple interactions | ISO | RGD:1352962 | 6480464 | [bisphenol A binds to CYP3A4 promoter] which results in decreased expression of CYP3A4 mRNA | CTD | PMID:12851153 PMID:12851153 |
| bosentan | increases expression | ISO | RGD:1352962 | 6480464 | bosentan results in increased expression of CYP3A4 mRNA | CTD | PMID:18332078 |
| bromocriptine | affects binding | ISO | RGD:1352962 | 6480464 | Bromocriptine binds to CYP3A4 protein | CTD | PMID:17198380 |
| bromocriptine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Bromocriptine | CTD | PMID:15286053 |
| bromodichloromethane | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of bromodichloromethane | CTD | PMID:12076521 |
| budesonide | decreases expression | EXP | | 6480464 | Budesonide results in decreased expression of CYP3A2 mRNA | CTD | PMID:20888898 |
| bufalin | multiple interactions | ISO | RGD:1352962 | 6480464 | bufalin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; more ... | CTD | PMID:22178124 |
| bufalin | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of bufalin | CTD | PMID:22178124 |
| bufalin | increases expression | ISO | RGD:1352962 | 6480464 | bufalin results in increased expression of CYP3A4 mRNA | CTD | PMID:22178124 |
| buprenorphine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Buprenorphine | CTD | PMID:16010532 |
| buprenorphine | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Buprenorphine | CTD | PMID:12756210 |
| buprenorphine | decreases alkylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased alkylation of Buprenorphine | CTD | PMID:15966752 |
| buprenorphine | decreases activity | ISO | RGD:1352962 | 6480464 | Buprenorphine results in decreased activity of CYP3A4 protein | CTD | PMID:12756210 |
| buspirone | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Buspirone | CTD | PMID:20716633 |
| buspirone | increases oxidation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased oxidation of Buspirone | CTD | PMID:15640381 |
| buspirone | multiple interactions | ISO | RGD:1352962 | 6480464 | resveratrol inhibits the reaction [CYP3A4 protein results in increased metabolism of Buspirone] | CTD | PMID:20716633 |
| butan-1-ol | multiple interactions | EXP | | 6480464 | 1-Butanol promotes the reaction [Toluene results in increased expression of CYP3A2 mRNA] | CTD | PMID:17209515 |
| caffeine | decreases activity | ISO | | 6480464 | Caffeine results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| calciol | increases expression | ISO | RGD:1352962 | 6480464 | Cholecalciferol metabolite results in increased expression of CYP3A4 | CTD | PMID:11991950 |
| calciol | decreases activity | ISO | RGD:1352962 | 6480464 | Cholecalciferol results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| calciol | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Cholecalciferol | CTD | PMID:16207822 |
| calciol | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; more ... | CTD | PMID:16207822 |
| calciol | increases expression | ISO | RGD:1352962 | 6480464 | Cholecalciferol results in increased expression of CYP3A4 mRNA | CTD | PMID:16207822 |
| calcitriol | multiple interactions | ISO | RGD:1352962 | 6480464 | Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein; more ... | CTD | PMID:17270371 |
| calcitriol | increases expression | ISO | RGD:1352962 | 6480464 | Calcitriol results in increased expression of CYP3A4 mRNA | CTD | PMID:11723248 more ... |
| calcitriol | multiple interactions | EXP | | 6480464 | Chenodeoxycholic Acid inhibits the reaction [Calcitriol results in increased expression of CYP3A2 mRNA] | CTD | PMID:20006981 |
| calcitriol | increases expression | EXP | | 6480464 | Calcitriol results in increased expression of CYP3A2 mRNA | CTD | PMID:20006981 |
| calcitriol | increases expression | ISO | RGD:1352962 | 6480464 | Calcitriol results in increased expression of CYP3A4 mRNA | CTD | PMID:11723248 more ... |
| calcitriol | multiple interactions | ISO | RGD:1352962 | 6480464 | Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | CTD | PMID:17270371 PMID:17965521 |
| calcitriol | increases expression | ISO | RGD:1352962 | 6480464 | Calcitriol results in increased expression of CYP3A4 mRNA | CTD | PMID:17270371 more ... |
| calcitriol | multiple interactions | ISO | RGD:1352962 | 6480464 | 2-acetyltributylcitrate promotes the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; more ... | CTD | PMID:21742782 |
| calcitriol | multiple interactions | ISO | RGD:1352962 | 6480464 | Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | CTD | PMID:17965521 PMID:17270371 |
| calcitriol | multiple interactions | ISO | RGD:1352962 | 6480464 | chrysin inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein]; more ... | CTD | PMID:19766177 |
| calcitriol | increases expression | ISO | RGD:1352962 | 6480464 | Calcitriol results in increased expression of CYP3A4 protein | CTD | PMID:11723248 |
| calcitriol | increases expression | ISO | RGD:1352962 | 6480464 | Calcitriol results in increased expression of CYP3A4 mRNA | CTD | PMID:11723248 more ... |
| calcitriol | multiple interactions | ISO | RGD:1352962 | 6480464 | anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; more ... | CTD | PMID:17965521 |
| calcitriol | increases activity | ISO | RGD:1352962 | 6480464 | Calcitriol results in increased activity of CYP3A4 protein | CTD | PMID:19766177 |
| capsaicin | decreases activity | ISO | RGD:1352962 | 6480464 | Capsaicin results in decreased activity of CYP3A4 protein | CTD | PMID:20388821 |
| carbamazepine | increases expression | ISO | RGD:1352962 | 6480464 | Carbamazepine results in increased expression of CYP3A4 mRNA | CTD | PMID:17954527 more ... |
| carbamazepine | increases expression | ISO | RGD:1352962 | 6480464 | Carbamazepine results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 more ... |
| carbamazepine | increases expression | ISO | RGD:1352962 | 6480464 | Carbamazepine results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 more ... |
| carbamazepine | increases activity | ISO | RGD:1352962 | 6480464 | Carbamazepine results in increased activity of CYP3A4 protein | CTD | PMID:9512926 PMID:12065438 |
| carbamazepine | multiple interactions | EXP | | 6480464 | [SOD2 co-treated with CYP3A4] affects the susceptibility to Carbamazepine | CTD | PMID:19501153 |
| carbamazepine | multiple interactions | ISO | RGD:1352962 | 6480464 | Probenecid promotes the reaction [CYP3A4 protein affects the metabolism of Carbamazepine] | CTD | PMID:15915352 |
| carbamazepine | multiple interactions | ISO | RGD:1352962 | 6480464 | NR3C1 protein promotes the reaction [Carbamazepine results in increased expression of CYP3A4 mRNA] | CTD | PMID:10219967 |
| carbamazepine | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide; more ... | CTD | PMID:12606595 |
| carbamazepine | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Carbamazepine | CTD | PMID:12606595 PMID:19255940 |
| carbamazepine | increases activity | ISO | RGD:1352962 | 6480464 | Carbamazepine results in increased activity of CYP3A4 protein | CTD | PMID:12065438 PMID:9512926 |
| carbamazepine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Carbamazepine | CTD | PMID:15286053 PMID:15915352 |
| carbamazepine | increases expression | ISO | RGD:1352962 | 6480464 | Carbamazepine results in increased expression of CYP3A4 mRNA | CTD | PMID:12673034 more ... |
| carbamazepine | multiple interactions | ISO | RGD:1352962 | 6480464 | Carbamazepine promotes the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of quetiapine] | CTD | PMID:16390352 |
| carbamazepine | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Carbamazepine | CTD | PMID:19255940 PMID:12606595 |
| carbaryl | increases expression | ISO | RGD:1352962 | 6480464 | Carbaryl results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| carbendazim | increases expression | ISO | RGD:1352962 | 6480464 | mecarzole results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| carbofuran | increases expression | ISO | RGD:1352962 | 6480464 | Carbofuran results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| carbofuran | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Carbofuran | CTD | PMID:15560889 |
| carbofuran | multiple interactions | ISO | RGD:1352962 | 6480464 | Carbofuran promotes the reaction [CYP3A4 protein affects the metabolism of Testosterone]; more ... | CTD | PMID:15560889 |
| carbofuran | increases activity | ISO | RGD:1352962 | 6480464 | Carbofuran results in increased activity of CYP3A4 protein | CTD | PMID:22310298 |
| carmustine | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin] | CTD | PMID:16087946 |
| cetirizine | decreases activity | ISO | RGD:1352962 | 6480464 | Cetirizine analog results in decreased activity of CYP3A4 protein; more ... | CTD | PMID:15482930 |
| chenodeoxycholic acid | multiple interactions | EXP | | 6480464 | Chenodeoxycholic Acid inhibits the reaction [Calcitriol results in increased expression of CYP3A2 mRNA] | CTD | PMID:20006981 |
| chitosan | increases activity | ISO | RGD:1352962 | 6480464 | Chitosan analog results in increased activity of CYP3A4 protein | CTD | PMID:20831879 |
| chlordecone | increases expression | ISO | RGD:1352962 | 6480464 | Chlordecone results in increased expression of CYP3A4 protein | CTD | PMID:15548381 |
| chlorfluazuron | increases expression | ISO | RGD:1352962 | 6480464 | chlorfluazuron results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| chloroquine | decreases activity | ISO | RGD:1352962 | 6480464 | Chloroquine results in decreased activity of CYP3A4 protein | CTD | PMID:11124226 |
| chloroquine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Chloroquine | CTD | PMID:12920490 |
| chlorpromazine | decreases activity | ISO | RGD:1352962 | 6480464 | Chlorpromazine results in decreased activity of CYP3A4 protein | CTD | PMID:15135088 |
| chlorpromazine | affects oxidation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the oxidation of Chlorpromazine | CTD | PMID:20615392 |
| chlorpromazine | affects methylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the methylation of Chlorpromazine | CTD | PMID:20615392 |
| chlorpromazine | multiple interactions | ISO | RGD:1352962 | 6480464 | [Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:17041008 |
| chlorpyrifos | multiple interactions | ISO | RGD:1352962 | 6480464 | [Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP3A4 protein | CTD | PMID:22515965 |
| chlorpyrifos | increases expression | ISO | RGD:1352962 | 6480464 | Chlorpyrifos results in increased expression of CYP3A4 mRNA | CTD | PMID:16757081 more ... |
| chlorpyrifos | increases expression | ISO | RGD:1352962 | 6480464 | Chlorpyrifos results in increased expression of CYP3A4 protein | CTD | PMID:15548381 PMID:22515965 |
| chlorpyrifos | increases expression | ISO | RGD:1352962 | 6480464 | Chlorpyrifos results in increased expression of CYP3A4 mRNA | CTD | PMID:16757081 more ... |
| chlorpyrifos | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Chlorpyrifos | CTD | PMID:17110060 PMID:17079358 |
| chlorpyrifos | decreases activity | ISO | RGD:1352962 | 6480464 | Chlorpyrifos results in decreased activity of CYP3A4 protein | CTD | PMID:15560889 PMID:16790556 |
| chlorpyrifos | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Chlorpyrifos | CTD | PMID:17079358 PMID:17110060 |
| chlorpyrifos | multiple interactions | ISO | RGD:1352962 | 6480464 | Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran] | CTD | PMID:15560889 |
| chlorpyrifos | increases expression | ISO | RGD:1352962 | 6480464 | Chlorpyrifos results in increased expression of CYP3A4 protein | CTD | PMID:15548381 |
| chlorpyrifos | increases expression | ISO | RGD:1352962 | 6480464 | Chlorpyrifos results in increased expression of CYP3A4 mRNA | CTD | PMID:16757081 |
| chlorpyrifos | decreases activity | ISO | RGD:1352962 | 6480464 | Chlorpyrifos results in decreased activity of CYP3A4 protein | CTD | PMID:16790556 PMID:15560889 |
| chlorpyrifos | affects metabolic processing | EXP | | 6480464 | CYP3A2 protein affects the metabolism of Chlorpyrifos | CTD | PMID:15587241 |
| chlorpyrifos | multiple interactions | ISO | RGD:1352962 | 6480464 | Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol]; more ... | CTD | PMID:16790556 |
| chlorpyrifos | decreases activity | EXP | | 6480464 | Chlorpyrifos results in decreased activity of CYP3A2 protein | CTD | PMID:15587241 |
| chlorpyrifos | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 results in increased metabolism of Chlorpyrifos | CTD | PMID:20709133 |
| chlorpyrifos | increases activity | ISO | RGD:1352962 | 6480464 | Chlorpyrifos results in increased activity of CYP3A4 protein | CTD | PMID:22310298 |
| chlorzoxazone | affects metabolic processing | EXP | | 6480464 | CYP3A2 protein affects the metabolism of Chlorzoxazone | CTD | PMID:15879494 |
| cholesterol | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased oxidation of Cholesterol] which results in increased chemical synthesis of cholest-5-ene-3,4-diol | CTD | PMID:11514559 |
| cholesterol | decreases activity | ISO | | 6480464 | Cholesterol results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| cimetidine | decreases activity | ISO | RGD:1352962 | 6480464 | Cimetidine results in decreased activity of CYP3A4 protein | CTD | PMID:16041596 PMID:2271712 |
| cimetidine | multiple interactions | ISO | RGD:1352962 | 6480464 | styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP3A4 protein] | CTD | PMID:19909766 |
| cimetidine | decreases activity | ISO | RGD:1352962 | 6480464 | Cimetidine results in decreased activity of CYP3A4 protein | CTD | PMID:16041596 more ... |
| cimetidine | decreases expression | ISO | RGD:1352962 | 6480464 | Cimetidine results in decreased expression of CYP3A4 protein | CTD | PMID:22733800 |
| cimetidine | multiple interactions | ISO | RGD:1352962 | 6480464 | [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein | CTD | PMID:22733800 |
| cimetidine | decreases activity | ISO | RGD:1352962 | 6480464 | Cimetidine results in decreased activity of CYP3A4 protein | CTD | PMID:2271712 PMID:16041596 |
| cinnamic acid | decreases activity | ISO | RGD:1352962 | 6480464 | cinnamic acid analog results in decreased activity of CYP3A4 protein | CTD | PMID:15072549 |
| ciprofibrate | decreases expression | EXP | | 6480464 | ciprofibrate results in decreased expression of CYP3A2 mRNA | CTD | PMID:7676460 |
| ciprofloxacin | decreases activity | ISO | RGD:1352962 | 6480464 | Ciprofloxacin results in decreased activity of CYP3A4 protein | CTD | PMID:11145498 |
| cis-ketoconazole | decreases activity | ISO | | 6480464 | Ketoconazole results in decreased activity of CYP3A2 protein | CTD | PMID:12814958 |
| cis-ketoconazole | decreases activity | ISO | | 6480464 | Ketoconazole results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| cis-ketoconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Ketoconazole results in decreased activity of CYP3A4 protein | CTD | PMID:15005856 more ... |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufalin]; more ... | CTD | PMID:22178124 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased glutathionylation of dauricine] | CTD | PMID:19358519 |
| cis-ketoconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Ketoconazole results in decreased activity of CYP3A4 protein | CTD | PMID:15005856 more ... |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine]; more ... | CTD | PMID:22651985 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone] | CTD | PMID:12569440 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] | CTD | PMID:21402137 |
| cis-ketoconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Ketoconazole results in decreased activity of CYP3A4 protein | CTD | PMID:15869686 more ... |
| cis-ketoconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Ketoconazole results in decreased activity of CYP3A4 protein | CTD | PMID:15557344 more ... |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758] | CTD | PMID:19230594 |
| cis-ketoconazole | decreases activity | EXP | | 6480464 | Ketoconazole results in decreased activity of CYP3A2 protein | CTD | PMID:15879494 PMID:12814958 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine | CTD | PMID:11502731 |
| cis-ketoconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Ketoconazole results in decreased activity of CYP3A4 protein | CTD | PMID:15005856 more ... |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Endosulfan] | CTD | PMID:20507880 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 2-oxo-clopidogrel] | CTD | PMID:19812348 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein] | CTD | PMID:16146350 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Triazolam] | CTD | PMID:10952769 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Terfenadine] | CTD | PMID:15869686 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan] | CTD | PMID:20307514 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod] | CTD | PMID:15764719 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of quetiapine] | CTD | PMID:16390352 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran] | CTD | PMID:15560889 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol] | CTD | PMID:16207822 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone] | CTD | PMID:11377097 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam]; more ... | CTD | PMID:9600717 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Endosulfan] | CTD | PMID:16855053 |
| cis-ketoconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Mefloquine] | CTD | PMID:15896247 |
| cis-ketoconazole | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Ketoconazole | CTD | PMID:17702393 |
| cis-ketoconazole | decreases activity | EXP | | 6480464 | Ketoconazole results in decreased activity of CYP3A2 protein | CTD | PMID:12814958 PMID:15879494 |
| cis-ketoconazole | multiple interactions | EXP | | 6480464 | Ketoconazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] | CTD | PMID:19858067 |
| cis-ketoconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Ketoconazole results in decreased activity of CYP3A2 protein | CTD | PMID:12814958 |
| cisapride | decreases activity | ISO | RGD:1352962 | 6480464 | Cisapride results in decreased activity of CYP3A4 protein | CTD | PMID:15306208 |
| cisapride | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Cisapride | CTD | PMID:11717173 |
| cisapride | affects chemical synthesis | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the chemical synthesis of Cisapride metabolite | CTD | PMID:11717173 |
| cisplatin | increases expression | ISO | RGD:1352962 | 6480464 | Cisplatin results in increased expression of CYP3A4 protein; more ... | CTD | PMID:15650019 |
| cisplatin | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin] | CTD | PMID:16087946 |
| citalopram | decreases methylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased methylation of Citalopram analog | CTD | PMID:9110356 |
| clarithromycin | multiple interactions | ISO | RGD:1352962 | 6480464 | Clarithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | CTD | PMID:16416302 |
| clarithromycin | multiple interactions | ISO | RGD:1352962 | 6480464 | [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline] | CTD | PMID:11408986 |
| clarithromycin | decreases expression | ISO | RGD:1352962 | 6480464 | Clarithromycin results in decreased expression of CYP3A4 mRNA | CTD | PMID:16837568 |
| clarithromycin | decreases activity | ISO | RGD:1352962 | 6480464 | Clarithromycin results in decreased activity of CYP3A4 protein | CTD | PMID:16416302 |
| clarithromycin | multiple interactions | ISO | RGD:1352962 | 6480464 | Clarithromycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Disopyramide] | CTD | PMID:10234723 |
| clofibric acid | multiple interactions | EXP | | 6480464 | Clofibric Acid results in increased expression of and results in increased activity of CYP3A2 protein; more ... | CTD | PMID:15788368 |
| clofibric acid | increases expression | ISO | RGD:1352962 | 6480464 | Clofibric Acid results in increased expression of CYP3A4 mRNA | CTD | PMID:15771232 |
| clofibric acid | increases activity | ISO | RGD:1352962 | 6480464 | Clofibric Acid results in increased activity of CYP3A4 protein | CTD | PMID:15771232 |
| clofibric acid | increases expression | EXP | | 6480464 | Clofibric Acid results in increased expression of CYP3A2 mRNA | CTD | PMID:15788368 |
| clotrimazole | increases expression | ISO | RGD:1352962 | 6480464 | Clotrimazole results in increased expression of CYP3A4 mRNA | CTD | PMID:12505310 more ... |
| clotrimazole | increases expression | ISO | RGD:1352962 | 6480464 | Clotrimazole results in increased expression of CYP3A4 mRNA | CTD | PMID:12505310 more ... |
| clotrimazole | increases expression | ISO | RGD:1352962 | 6480464 | Clotrimazole results in increased expression of CYP3A4 mRNA | CTD | PMID:15466163 more ... |
| clotrimazole | increases expression | ISO | RGD:1352962 | 6480464 | Clotrimazole results in increased expression of CYP3A4 protein | CTD | PMID:8632764 |
| clotrimazole | increases expression | ISO | RGD:1352962 | 6480464 | Clotrimazole results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 more ... |
| clotrimazole | increases activity | ISO | RGD:1352962 | 6480464 | Clotrimazole results in increased activity of CYP3A4 protein | CTD | PMID:12065438 PMID:14977870 |
| clotrimazole | decreases activity | ISO | RGD:1352962 | 6480464 | Clotrimazole results in decreased activity of CYP3A4 protein | CTD | PMID:15135088 |
| clotrimazole | multiple interactions | EXP | | 6480464 | Clotrimazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] | CTD | PMID:19858067 |
| clozapine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Clozapine | CTD | PMID:15286053 |
| clozapine | multiple interactions | ISO | RGD:1352962 | 6480464 | Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; more ... | CTD | PMID:21402137 |
| cobalt dichloride | decreases expression | ISO | RGD:1352962 | 6480464 | cobaltous chloride results in decreased expression of CYP3A4 mRNA; more ... | CTD | PMID:19695866 |
| codeine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Codeine | CTD | PMID:15286053 |
| cordycepin | multiple interactions | EXP | | 6480464 | cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA] | CTD | PMID:11181506 |
| corticosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | [Corticosterone binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | CTD | PMID:12851153 |
| corticosterone | increases metabolic processing | ISO | | 6480464 | Corticosterone results in increased metabolism of CYP3A4 protein | CTD | PMID:20032461 |
| corticosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | [Corticosterone binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | CTD | PMID:12851153 PMID:12851153 |
| corticosterone | increases metabolic processing | ISO | RGD:1619215 | 6480464 | Corticosterone results in increased metabolism of CYP3A4 protein | CTD | PMID:20032461 |
| corticosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | Corticosterone promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | CTD | PMID:11581012 |
| cortisol | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Hydrocortisone | CTD | PMID:15025748 more ... |
| cortisol | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 promoter mutant form inhibits the reaction [Hydrocortisone results in increased expression of CYP3A4 mRNA] | CTD | PMID:12505310 PMID:12505310 |
| cortisol | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Hydrocortisone | CTD | PMID:15025748 more ... |
| cortisol | increases expression | EXP | | 6480464 | Hydrocortisone results in increased expression of CYP3A2 mRNA | CTD | PMID:10476907 |
| cortisol | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Hydrocortisone | CTD | PMID:16024008 more ... |
| cortisol | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Hydrocortisone | CTD | PMID:15941677 more ... |
| cortisol | multiple interactions | ISO | RGD:1352962 | 6480464 | kaempferol inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone]; more ... | CTD | PMID:15266218 |
| cortisol | increases expression | ISO | RGD:1352962 | 6480464 | Hydrocortisone results in increased expression of CYP3A4 mRNA | CTD | PMID:12505310 |
| cortisol | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 promoter mutant form inhibits the reaction [Hydrocortisone results in increased expression of CYP3A4 mRNA] | CTD | PMID:12505310 |
| cortisol | affects hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the hydroxylation of Hydrocortisone | CTD | PMID:2271712 |
| cortisol | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Hydrocortisone | CTD | PMID:11907490 |
| coumarin | affects expression | EXP | | 6480464 | coumarin affects the expression of CYP3A2 mRNA | CTD | PMID:16963487 |
| curcumin | multiple interactions | ISO | RGD:1352962 | 6480464 | Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein] | CTD | PMID:17270371 |
| curcumin | decreases expression | ISO | RGD:1352962 | 6480464 | Curcumin results in decreased expression of CYP3A4 mRNA | CTD | PMID:20816778 |
| curcumin | multiple interactions | ISO | RGD:1352962 | 6480464 | Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | CTD | PMID:17270371 PMID:17965521 |
| curcumin | multiple interactions | ISO | RGD:1352962 | 6480464 | Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | CTD | PMID:17965521 PMID:17270371 |
| curcumin | increases expression | ISO | RGD:1352962 | 6480464 | Curcumin results in increased expression of CYP3A4 mRNA | CTD | PMID:17210444 |
| cycloheximide | multiple interactions | EXP | | 6480464 | Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA] | CTD | PMID:11181506 |
| cycloheximide | decreases expression | ISO | RGD:1352962 | 6480464 | Cycloheximide results in decreased expression of CYP3A4 mRNA | CTD | PMID:21466820 |
| cyclophosphamide | increases expression | EXP | | 6480464 | Cyclophosphamide results in increased expression of CYP3A2 protein; more ... | CTD | PMID:16019949 |
| cyclophosphamide | decreases activity | ISO | | 6480464 | Cyclophosphamide results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| cyclophosphamide | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Cyclophosphamide | CTD | PMID:11377097 |
| cyclophosphamide | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Cyclophosphamide | CTD | PMID:16087946 |
| cyclophosphamide | affects response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 gene polymorphism affects the susceptibility to Cyclophosphamide | CTD | PMID:16087946 |
| cyclophosphamide | multiple interactions | ISO | RGD:1352962 | 6480464 | [Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:17041008 |
| cyclophosphamide | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin] | CTD | PMID:16087946 |
| cyclophosphamide | increases expression | ISO | RGD:1352962 | 6480464 | Cyclophosphamide results in increased expression of CYP3A4 mRNA | CTD | PMID:18839173 |
| cyclosporin A | decreases expression | ISO | RGD:1352962 | 6480464 | Cyclosporine results in decreased expression of CYP3A4 mRNA | CTD | PMID:20106945 |
| cyclosporin A | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Cyclosporine | CTD | PMID:15286053 more ... |
| cyclosporin A | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Cyclosporine | CTD | PMID:15964336 more ... |
| cyclosporin A | decreases expression | ISO | RGD:1619215 | 6480464 | Cyclosporine results in decreased expression of CYP3A41A mRNA | CTD | PMID:19770486 |
| cyclosporin A | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Cyclosporine | CTD | PMID:15964336 more ... |
| cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of CYP3A4 mRNA | CTD | PMID:19224547 |
| cyclosporin A | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Cyclosporine | CTD | PMID:20599501 |
| cyclosporin A | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Cyclosporine | CTD | PMID:15450954 more ... |
| cyclosporin A | increases expression | ISO | RGD:1352962 | 6480464 | Cyclosporine results in increased expression of CYP3A4 mRNA | CTD | PMID:12673034 |
| cyclosporin A | multiple interactions | ISO | RGD:1352962 | 6480464 | Cyclosporine inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide]; more ... | CTD | PMID:8114683 |
| cyfluthrin | increases expression | ISO | RGD:1352962 | 6480464 | cyfluthrin results in increased expression of CYP3A4 mRNA | CTD | PMID:19249324 |
| cyhalothrin | increases activity | ISO | RGD:1352962 | 6480464 | cyhalothrin results in increased activity of CYP3A4 protein | CTD | PMID:22310298 |
| cyhalothrin | increases expression | ISO | RGD:1352962 | 6480464 | cyhalothrin results in increased expression of CYP3A4 mRNA | CTD | PMID:19249324 PMID:22310298 |
| cyhalothrin | increases expression | ISO | RGD:1352962 | 6480464 | cyhalothrin results in increased expression of CYP3A4 protein; more ... | CTD | PMID:19249324 |
| cypermethrin | increases expression | ISO | RGD:1352962 | 6480464 | cypermethrin results in increased expression of CYP3A4 protein | CTD | PMID:15548381 |
| cypermethrin | decreases activity | ISO | RGD:1352962 | 6480464 | cypermethrin results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| cypermethrin | increases expression | ISO | RGD:1352962 | 6480464 | cypermethrin results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| cypermethrin | increases activity | ISO | RGD:1352962 | 6480464 | cypermethrin results in increased activity of CYP3A4 protein | CTD | PMID:22310298 |
| cyproterone acetate | increases expression | ISO | RGD:1352962 | 6480464 | Cyproterone Acetate results in increased expression of CYP3A4 mRNA | CTD | PMID:12505310 |
| daidzein | decreases activity | ISO | RGD:1352962 | 6480464 | daidzein results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| dapsone | multiple interactions | EXP | | 6480464 | [SOD2 co-treated with CYP3A4] affects the susceptibility to Dapsone | CTD | PMID:19501153 |
| dapsone | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Dapsone | CTD | PMID:15327588 PMID:12920490 |
| dapsone | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Dapsone | CTD | PMID:12920490 PMID:15327588 |
| dauricine | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of N-desmethyldauricine; more ... | CTD | PMID:19358519 |
| dauricine | increases glutathionylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased glutathionylation of dauricine | CTD | PMID:19358519 |
| DDD | increases expression | ISO | RGD:1352962 | 6480464 | Dichlorodiphenyldichloroethane results in increased expression of CYP3A4 mRNA | CTD | PMID:20686338 |
| DDE | increases expression | ISO | RGD:1352962 | 6480464 | Dichlorodiphenyl Dichloroethylene results in increased expression of CYP3A4 mRNA | CTD | PMID:20686338 |
| DDT | increases expression | ISO | RGD:1352962 | 6480464 | DDT results in increased expression of CYP3A4 mRNA | CTD | PMID:17035600 PMID:20686338 |
| DDT | increases expression | ISO | RGD:1352962 | 6480464 | DDT results in increased expression of CYP3A4 protein | CTD | PMID:15548381 |
| DDT | increases expression | ISO | RGD:1352962 | 6480464 | DDT results in increased expression of CYP3A4 mRNA | CTD | PMID:17035600 |
| DDT | multiple interactions | EXP | | 6480464 | [DDT co-treated with Diethylnitrosamine] results in increased expression of CYP3A2 mRNA; more ... | CTD | PMID:15885732 |
| dehydroepiandrosterone | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Dehydroepiandrosterone | CTD | PMID:15845858 |
| dehydroepiandrosterone sulfate | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Dehydroepiandrosterone Sulfate | CTD | PMID:2271712 |
| delta-tocotrienol | increases expression | ISO | RGD:1352962 | 6480464 | tocotrienol, delta results in increased expression of CYP3A4 | CTD | PMID:15269186 |
| deoxycholic acid | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Deoxycholic Acid | CTD | PMID:15708356 |
| deoxycholic acid | decreases expression | EXP | | 6480464 | Deoxycholic Acid results in decreased expression of CYP3A2 mRNA | CTD | PMID:10453939 |
| deoxycholic acid | multiple interactions | EXP | | 6480464 | Deoxycholic Acid results in decreased expression of and results in decreased activity of CYP3A2 protein; more ... | CTD | PMID:10453939 |
| desferrioxamine B | decreases expression | ISO | RGD:1352962 | 6480464 | Deferoxamine results in decreased expression of CYP3A4 mRNA; more ... | CTD | PMID:19695866 |
| desipramine | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased susceptibility to Desipramine | CTD | PMID:21540358 |
| desipramine | decreases activity | ISO | RGD:1352962 | 6480464 | Desipramine results in decreased activity of CYP3A4 protein | CTD | PMID:15135088 |
| dexamethasone | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 promoter mutant form inhibits the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA] | CTD | PMID:12505310 PMID:12505310 |
| dexamethasone | increases expression | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 more ... |
| dexamethasone | increases activity | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased activity of CYP3A4 protein | CTD | PMID:10923861 more ... |
| dexamethasone | multiple interactions | ISO | RGD:1352962 | 6480464 | Dexamethasone promotes the reaction [fenvalerate results in increased expression of CYP3A4 mRNA]; more ... | CTD | PMID:20599767 |
| dexamethasone | multiple interactions | ISO | RGD:1352962 | 6480464 | [Dexamethasone co-treated with Diethylhexyl Phthalate] results in increased activity of CYP3A4 protein; more ... | CTD | PMID:18332045 |
| dexamethasone | multiple interactions | ISO | RGD:1352962 | 6480464 | [Dexamethasone binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | CTD | PMID:12851153 PMID:12851153 |
| dexamethasone | multiple interactions | ISO | | 6480464 | NR1I2 affects the reaction [Dexamethasone results in increased activity of CYP3A4 protein] | CTD | PMID:20361990 |
| dexamethasone | multiple interactions | EXP | | 6480464 | Plant Preparations promotes the reaction [Dexamethasone results in increased expression of CYP3A2 mRNA] | CTD | PMID:21084653 |
| dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of CYP3A2 mRNA | CTD | PMID:20607812 PMID:21084653 |
| dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of CYP3A2 mRNA | CTD | PMID:20607812 |
| dexamethasone | increases expression | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased expression of CYP3A4 protein | CTD | PMID:12695351 more ... |
| dexamethasone | increases expression | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 more ... |
| dexamethasone | increases activity | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased activity of CYP3A4 protein | CTD | PMID:10923861 more ... |
| dexamethasone | increases expression | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased expression of CYP3A4 protein | CTD | PMID:15548381 more ... |
| dexamethasone | increases expression | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased expression of CYP3A4 mRNA | CTD | PMID:12695351 more ... |
| dexamethasone | increases activity | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased activity of CYP3A4 protein | CTD | PMID:9512926 more ... |
| dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of CYP3A2 protein | CTD | PMID:15258109 PMID:15588932 |
| dexamethasone | increases expression | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased expression of CYP3A4 protein | CTD | PMID:15548381 more ... |
| dexamethasone | multiple interactions | ISO | RGD:1352962 | 6480464 | Mifepristone inhibits the reaction [NR3C1 protein promotes the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA]] | CTD | PMID:10219967 |
| dexamethasone | increases expression | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 more ... |
| dexamethasone | increases activity | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased activity of CYP3A4 protein | CTD | PMID:11409940 more ... |
| dexamethasone | multiple interactions | ISO | RGD:1352962 | 6480464 | Dexamethasone inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]; more ... | CTD | PMID:8114683 |
| dexamethasone | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 promoter mutant form inhibits the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA] | CTD | PMID:12505310 |
| dexamethasone | multiple interactions | ISO | RGD:1352962 | 6480464 | [Dexamethasone binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | CTD | PMID:12851153 |
| dexamethasone | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Dexamethasone | CTD | PMID:8114683 |
| dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of CYP3A2 protein | CTD | PMID:15588932 PMID:15258109 |
| dexamethasone | affects expression | EXP | | 6480464 | Dexamethasone affects the expression of CYP3A2 mRNA | CTD | PMID:15102944 |
| dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of CYP3A4 mRNA | CTD | PMID:20035846 |
| dexamethasone | increases expression | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 more ... |
| dexamethasone | increases activity | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased activity of CYP3A4 protein | CTD | PMID:10923861 more ... |
| dexamethasone | increases activity | ISO | | 6480464 | Dexamethasone results in increased activity of CYP3A4 protein | CTD | PMID:20361990 |
| dexamethasone | increases expression | ISO | RGD:1352962 | 6480464 | Dexamethasone results in increased expression of CYP3A4 protein | CTD | PMID:10640517 more ... |
| dextromethorphan | decreases methylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased methylation of Dextromethorphan | CTD | PMID:15383492 |
| dextromethorphan | decreases activity | ISO | | 6480464 | Dextromethorphan results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| dextromethorphan | multiple interactions | ISO | RGD:1352962 | 6480464 | Dextromethorphan inhibits the reaction [[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein] | CTD | PMID:19818743 |
| dextromethorphan | increases oxidation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased oxidation of Dextromethorphan | CTD | PMID:15383492 |
| dextromethorphan | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Dextromethorphan | CTD | PMID:17267297 |
| dextromethorphan | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Dextromethorphan | CTD | PMID:15988119 |
| dextrorphan | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Dextrorphan | CTD | PMID:15988119 |
| diallyl disulfide | increases expression | EXP | | 6480464 | diallyl disulfide results in increased expression of CYP3A2 protein | CTD | PMID:16000231 |
| diarsenic trioxide | increases expression | ISO | RGD:1352962 | 6480464 | arsenic trioxide results in increased expression of CYP3A4 mRNA | CTD | PMID:20458559 |
| diazepam | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Diazepam | CTD | PMID:16048486 |
| diazepam | multiple interactions | ISO | RGD:1352962 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Diazepam promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] | CTD | PMID:21402137 |
| diazinon | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Diazinon | CTD | PMID:15764407 |
| diazinon | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of and results in increased activity of Diazinon | CTD | PMID:11708902 |
| diazinon | increases expression | ISO | RGD:1352962 | 6480464 | Diazinon results in increased expression of CYP3A4 mRNA | CTD | PMID:16757081 |
| diazinon | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased sulfation of and results in increased activity of Diazinon | CTD | PMID:15764407 |
| dibutyl phthalate | multiple interactions | ISO | RGD:1352962 | 6480464 | Dibutyl Phthalate promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | CTD | PMID:21742782 |
| diclofenac | increases expression | ISO | RGD:1352962 | 6480464 | Diclofenac results in increased expression of CYP3A4 mRNA | CTD | PMID:19022234 |
| diclofenac | decreases activity | ISO | | 6480464 | Diclofenac results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| diclofenac | decreases activity | ISO | RGD:1352962 | 6480464 | Diclofenac results in decreased activity of CYP3A4 protein | CTD | PMID:15135088 |
| dieldrin | increases expression | ISO | RGD:1352962 | 6480464 | Dieldrin results in increased expression of CYP3A4 protein | CTD | PMID:15548381 |
| dieldrin | multiple interactions | ISO | RGD:1352962 | 6480464 | Dieldrin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | CTD | PMID:12417264 |
| diethyl phthalate | increases expression | EXP | | 6480464 | diethyl phthalate results in increased expression of CYP3A2 protein | CTD | PMID:16641546 |
| diethylstilbestrol | increases expression | ISO | RGD:1352962 | 6480464 | Diethylstilbestrol results in increased expression of CYP3A4 mRNA | CTD | PMID:23384967 |
| diethylstilbestrol | increases activity | ISO | RGD:1352962 | 6480464 | Diethylstilbestrol results in increased activity of CYP3A4 protein | CTD | PMID:23384967 |
| diflubenzuron | increases activity | ISO | RGD:1619215 | 6480464 | Diflubenzuron results in increased activity of CYP3A2 protein | CTD | PMID:15582210 |
| diflubenzuron | increases activity | ISO | | 6480464 | Diflubenzuron results in increased activity of CYP3A2 protein | CTD | PMID:15582210 |
| dihydroergotamine | decreases activity | ISO | RGD:1352962 | 6480464 | Dihydroergotamine results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| diltiazem | decreases activity | ISO | RGD:1352962 | 6480464 | Diltiazem results in decreased activity of CYP3A4 protein | CTD | PMID:22652334 |
| diltiazem | multiple interactions | ISO | RGD:1352962 | 6480464 | Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; more ... | CTD | PMID:22652334 |
| diltiazem | decreases methylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased methylation of Diltiazem | CTD | PMID:15499178 |
| diltiazem | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Diltiazem | CTD | PMID:15286053 |
| dimethyl sulfoxide | affects expression | ISO | RGD:1352962 | 6480464 | Dimethyl Sulfoxide affects the expression of CYP3A4 mRNA | CTD | PMID:12843640 |
| dimethyl sulfoxide | multiple interactions | EXP | | 6480464 | Dimethyl Sulfoxide inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] | CTD | PMID:19858067 |
| dioleoyl phosphatidylcholine | multiple interactions | ISO | RGD:1352962 | 6480464 | [1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A4 protein | CTD | PMID:1627548 |
| dioleoyl phosphatidylcholine | multiple interactions | EXP | | 6480464 | [1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A2 protein | CTD | PMID:1627548 |
| diosmetin | multiple interactions | ISO | RGD:1352962 | 6480464 | diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; more ... | CTD | PMID:18191104 |
| dioxygen | decreases expression | ISO | RGD:1352962 | 6480464 | Oxygen deficiency results in decreased expression of CYP3A4 mRNA | CTD | PMID:19695866 |
| dioxygen | multiple interactions | ISO | RGD:1352962 | 6480464 | Oxygen deficiency inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Paclitaxel]; more ... | CTD | PMID:19695866 |
| dioxygen | multiple interactions | ISO | RGD:1352962 | 6480464 | [[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; more ... | CTD | PMID:21766881 |
| dipropyl disulfide | increases expression | EXP | | 6480464 | n-propyl disulfide results in increased expression of CYP3A2 protein | CTD | PMID:16000231 |
| diquat | decreases expression | EXP | | 6480464 | Diquat results in decreased expression of CYP3A2 mRNA | CTD | PMID:7676460 |
| disopyramide | multiple interactions | ISO | RGD:1352962 | 6480464 | Clarithromycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Disopyramide] | CTD | PMID:10234723 |
| disopyramide | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Disopyramide | CTD | PMID:10901704 |
| disulfiram | decreases expression | EXP | | 6480464 | Disulfiram results in decreased expression of CYP3A2 mRNA | CTD | PMID:9393675 |
| disulfiram | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased susceptibility to Disulfiram | CTD | PMID:21540358 |
| disulfiram | decreases activity | EXP | | 6480464 | Disulfiram results in decreased activity of CYP3A2 protein | CTD | PMID:9393675 |
| diuron | increases expression | ISO | RGD:1352962 | 6480464 | Diuron results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| docetaxel anhydrous | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 mRNA results in increased susceptibility to docetaxel | CTD | PMID:15239142 |
| docetaxel anhydrous | increases expression | ISO | RGD:1352962 | 6480464 | docetaxel results in increased expression of CYP3A4 mRNA | CTD | PMID:18839173 |
| domperidone | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of and results in decreased alkylation of Domperidone | CTD | PMID:15327587 |
| dopamine | decreases activity | ISO | RGD:1352962 | 6480464 | Dopamine results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| econazole | decreases activity | ISO | RGD:1352962 | 6480464 | Econazole results in decreased activity of CYP3A4 protein | CTD | PMID:15135088 |
| elemental selenium | decreases expression | ISO | RGD:1352962 | 6480464 | Selenium results in decreased expression of CYP3A4 mRNA | CTD | PMID:19244175 |
| endosulfan | multiple interactions | ISO | RGD:1352962 | 6480464 | [Endosulfan co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA | CTD | PMID:20361990 |
| endosulfan | multiple interactions | ISO | | 6480464 | NR1I2 affects the reaction [Endosulfan results in increased activity of CYP3A4 protein]; more ... | CTD | PMID:20361990 |
| endosulfan | increases expression | ISO | | 6480464 | Endosulfan results in increased expression of CYP3A4 protein | CTD | PMID:20361990 |
| endosulfan | increases activity | ISO | | 6480464 | Endosulfan results in increased activity of CYP3A4 protein | CTD | PMID:20361990 |
| endosulfan | increases expression | ISO | RGD:1352962 | 6480464 | Endosulfan results in increased expression of CYP3A4 protein | CTD | PMID:15548381 PMID:20361990 |
| endosulfan | increases expression | ISO | RGD:1352962 | 6480464 | Endosulfan results in increased expression of CYP3A4 mRNA | CTD | PMID:12417264 PMID:22515965 |
| endosulfan | multiple interactions | ISO | RGD:1352962 | 6480464 | [Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP3A4 protein | CTD | PMID:22515965 |
| endosulfan | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Endosulfan] | CTD | PMID:16855053 |
| endosulfan | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Endosulfan] | CTD | PMID:20507880 |
| endosulfan | increases expression | ISO | RGD:1352962 | 6480464 | Endosulfan results in increased expression of CYP3A4 protein | CTD | PMID:15548381 |
| endosulfan | increases expression | ISO | RGD:1352962 | 6480464 | Endosulfan results in increased expression of CYP3A4 mRNA | CTD | PMID:12417264 |
| endosulfan | multiple interactions | ISO | RGD:1352962 | 6480464 | Endosulfan promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | CTD | PMID:12417264 |
| endosulfan | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased susceptibility to Endosulfan | CTD | PMID:20507880 |
| endosulfan | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Endosulfan | CTD | PMID:16581944 PMID:16855053 |
| erythromycin A | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Erythromycin | CTD | PMID:8114683 |
| erythromycin A | decreases activity | ISO | | 6480464 | Erythromycin results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| erythromycin A | multiple interactions | ISO | RGD:1352962 | 6480464 | IFNA protein inhibits the reaction [CYP3A4 protein results in increased metabolism of Erythromycin] | CTD | PMID:21466820 |
| erythromycin A | decreases activity | ISO | RGD:1352962 | 6480464 | Erythromycin results in decreased activity of CYP3A4 protein | CTD | PMID:15466163 more ... |
| erythromycin A | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Erythromycin | CTD | PMID:21466820 |
| erythromycin A | decreases activity | ISO | RGD:1352962 | 6480464 | Erythromycin results in decreased activity of CYP3A4 protein | CTD | PMID:15845683 more ... |
| erythromycin A | decreases activity | ISO | RGD:1352962 | 6480464 | Erythromycin results in decreased activity of CYP3A4 protein | CTD | PMID:16041596 more ... |
| erythromycin A | decreases activity | ISO | RGD:1352962 | 6480464 | Erythromycin results in decreased activity of CYP3A4 protein | CTD | PMID:16416302 more ... |
| erythromycin A | multiple interactions | ISO | RGD:1352962 | 6480464 | Erythromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide]; more ... | CTD | PMID:8114683 |
| erythromycin A | multiple interactions | ISO | RGD:1352962 | 6480464 | Erythromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | CTD | PMID:16416302 |
| erythromycin A | multiple interactions | ISO | RGD:1352962 | 6480464 | Erythromycin inhibits the reaction [CYP3A4 protein affects the metabolism of brotizolam] | CTD | PMID:16042670 |
| erythromycin A | decreases methylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased methylation of Erythromycin | CTD | PMID:15383492 PMID:2271712 |
| erythrosine sodium | decreases activity | ISO | RGD:1352962 | 6480464 | Erythrosine results in decreased activity of CYP3A4 protein | CTD | PMID:20041016 |
| estazolam | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Estazolam | CTD | PMID:16012077 |
| estrone | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine] | CTD | PMID:21907773 |
| etonogestrel | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of 3-keto-desogestrel | CTD | PMID:15963096 |
| etoposide | multiple interactions | ISO | RGD:1352962 | 6480464 | Cyclosporine inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]; more ... | CTD | PMID:8114683 |
| etoposide | decreases methylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased methylation of Etoposide | CTD | PMID:8114683 |
| etoposide | affects response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the susceptibility to Etoposide | CTD | PMID:17279585 |
| etoposide | affects response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 gene polymorphism affects the susceptibility to Etoposide | CTD | PMID:12969965 |
| etoricoxib | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of etoricoxib | CTD | PMID:18084859 |
| farnesol | increases activity | EXP | | 6480464 | Farnesol results in increased activity of CYP3A2 protein | CTD | PMID:15840382 |
| felbamate | multiple interactions | ISO | RGD:1352962 | 6480464 | felbamate affects the reaction [[CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide] | CTD | PMID:12606595 |
| fenitrothion | increases activity | ISO | RGD:1352962 | 6480464 | Fenitrothion results in increased activity of CYP3A4 protein | CTD | PMID:22310298 |
| fenitrothion | increases expression | ISO | RGD:1352962 | 6480464 | Fenitrothion results in increased expression of CYP3A4 mRNA | CTD | PMID:17293382 PMID:22310298 |
| fenitrothion | increases expression | ISO | RGD:1352962 | 6480464 | Fenitrothion results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| fentanyl | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Fentanyl | CTD | PMID:11811955 |
| fenthion | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Fenthion | CTD | PMID:17110060 |
| fenvalerate | increases expression | ISO | RGD:1352962 | 6480464 | fenvalerate results in increased expression of CYP3A4 protein | CTD | PMID:15548381 |
| fenvalerate | increases expression | ISO | RGD:1352962 | 6480464 | fenvalerate results in increased expression of CYP3A4 mRNA | CTD | PMID:19249324 more ... |
| fenvalerate | multiple interactions | ISO | RGD:1352962 | 6480464 | fenvalerate promotes the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA]; more ... | CTD | PMID:20599767 |
| fenvalerate | increases activity | ISO | RGD:1352962 | 6480464 | fenvalerate results in increased activity of CYP3A4 protein | CTD | PMID:22310298 |
| fenvalerate | increases expression | ISO | RGD:1352962 | 6480464 | fenvalerate results in increased expression of CYP3A4 mRNA | CTD | PMID:19249324 PMID:22310298 |
| fenvalerate | increases expression | ISO | RGD:1352962 | 6480464 | fenvalerate results in increased expression of CYP3A4 mRNA | CTD | PMID:19249324 |
| ferroheme b | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; more ... | CTD | PMID:22390216 |
| fipronil | multiple interactions | ISO | RGD:1352962 | 6480464 | fipronil promotes the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; more ... | CTD | PMID:17084830 |
| fipronil | increases expression | ISO | RGD:1352962 | 6480464 | fipronil results in increased expression of CYP3A4 mRNA | CTD | PMID:17084830 |
| flavanone | decreases activity | ISO | RGD:1352962 | 6480464 | flavanone results in decreased activity of CYP3A4 protein | CTD | PMID:21053930 |
| flavanone | multiple interactions | ISO | RGD:1352962 | 6480464 | flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; more ... | CTD | PMID:21053930 |
| flavone | multiple interactions | ISO | RGD:1352962 | 6480464 | flavone binds to and results in decreased activity of CYP3A4 protein; more ... | CTD | PMID:21053930 |
| flavonol | decreases activity | ISO | RGD:1352962 | 6480464 | 3-hydroxyflavone results in decreased activity of CYP3A4 protein | CTD | PMID:21053930 |
| flucloxacillin | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 results in increased metabolism of Floxacillin | CTD | PMID:11409940 |
| fluconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Fluconazole results in decreased activity of CYP3A4 protein | CTD | PMID:15784650 PMID:15843491 |
| fluconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Fluconazole results in decreased activity of CYP3A4 protein | CTD | PMID:15843491 PMID:15784650 |
| fluoren-9-one | increases expression | EXP | | 6480464 | 9-fluorenone results in increased expression of CYP3A2 protein | CTD | PMID:10445401 |
| fluorene | increases expression | EXP | | 6480464 | fluorene results in increased expression of CYP3A2 protein | CTD | PMID:10445401 |
| fluoxetine | multiple interactions | ISO | RGD:1352962 | 6480464 | Fluoxetine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | CTD | PMID:12584149 |
| fluoxetine | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Fluoxetine | CTD | PMID:11752104 |
| fluoxetine | multiple interactions | ISO | RGD:1352962 | 6480464 | Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Fluoxetine] | CTD | PMID:11752104 |
| fluphenazine | decreases activity | ISO | RGD:1352962 | 6480464 | Fluphenazine results in decreased activity of CYP3A4 protein | CTD | PMID:15135088 |
| flutamide | increases activity | ISO | RGD:1352962 | 6480464 | Flutamide results in increased activity of CYP3A4 protein | CTD | PMID:18839173 |
| flutamide | increases expression | ISO | RGD:1352962 | 6480464 | Flutamide results in increased expression of CYP3A4 mRNA | CTD | PMID:18839173 |
| flutamide | multiple interactions | EXP | | 6480464 | [SOD2 co-treated with CYP3A4] affects the susceptibility to Flutamide | CTD | PMID:19501153 |
| fluvoxamine | multiple interactions | ISO | RGD:1352962 | 6480464 | Fluvoxamine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | CTD | PMID:12584149 |
| fonofos | multiple interactions | ISO | RGD:1352962 | 6480464 | Fonofos inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol]; more ... | CTD | PMID:16790556 |
| fonofos | decreases activity | ISO | RGD:1352962 | 6480464 | Fonofos results in decreased activity of CYP3A4 protein | CTD | PMID:16790556 |
| fulvestrant | increases expression | EXP | | 6480464 | fulvestrant results in increased expression of CYP3A2 mRNA | CTD | PMID:16837770 |
| furathiocarb | increases expression | ISO | RGD:1352962 | 6480464 | deltanit results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| furathiocarb | increases activity | ISO | RGD:1352962 | 6480464 | deltanit results in increased activity of CYP3A4 protein | CTD | PMID:22310298 |
| gadolinium trichloride | multiple interactions | EXP | | 6480464 | gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 mRNA]; more ... | CTD | PMID:18202523 |
| gadolinium trichloride | multiple interactions | EXP | | 6480464 | gadolinium chloride inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein] | CTD | PMID:18079364 |
| galangin | multiple interactions | ISO | RGD:1352962 | 6480464 | galangin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; more ... | CTD | PMID:21053930 |
| galangin | decreases activity | ISO | RGD:1352962 | 6480464 | galangin results in decreased activity of CYP3A4 protein | CTD | PMID:21053930 |
| gamma-hexachlorocyclohexane | increases expression | EXP | | 6480464 | Lindane results in increased expression of CYP3A2 mRNA | CTD | PMID:16837770 |
| gamma-hexachlorocyclohexane | increases activity | EXP | | 6480464 | Lindane results in increased activity of CYP3A2 protein | CTD | PMID:3569844 |
| gamma-hexachlorocyclohexane | increases expression | ISO | RGD:1352962 | 6480464 | Lindane results in increased expression of CYP3A4 protein | CTD | PMID:15548381 |
| gamma-hexachlorocyclohexane | increases expression | EXP | | 6480464 | Lindane results in increased expression of CYP3A2 protein | CTD | PMID:11684361 |
| gefitinib | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of gefitinib | CTD | PMID:15788367 |
| gemfibrozil | increases expression | ISO | RGD:1352962 | 6480464 | Gemfibrozil results in increased expression of CYP3A4 mRNA | CTD | PMID:15771232 |
| gemfibrozil | increases activity | ISO | RGD:1352962 | 6480464 | Gemfibrozil results in increased activity of CYP3A4 protein | CTD | PMID:15771232 |
| genistein | decreases activity | ISO | RGD:1352962 | 6480464 | Genistein results in decreased activity of CYP3A4 protein | CTD | PMID:21053930 |
| genistein | multiple interactions | ISO | RGD:1352962 | 6480464 | Genistein inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein] | CTD | PMID:19766177 |
| glutathione | multiple interactions | ISO | RGD:1352962 | 6480464 | Glutathione affects the reaction [CYP3A4 protein binds to 1-pyrenebutanol]; more ... | CTD | PMID:18206979 |
| glutathione | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine | CTD | PMID:20825217 |
| glutathione | multiple interactions | EXP | | 6480464 | [CYP3A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine | CTD | PMID:20825217 |
| glutathione | multiple interactions | ISO | RGD:1352962 | 6480464 | Glutathione inhibits the reaction [Saquinavir results in decreased activity of CYP3A4 protein] | CTD | PMID:15523003 |
| glutathione | affects binding | ISO | RGD:1352962 | 6480464 | Glutathione binds to CYP3A4 protein | CTD | PMID:18206979 |
| glycyrrhizinic acid | increases expression | ISO | RGD:1352962 | 6480464 | Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA; more ... | CTD | PMID:22982774 |
| glycyrrhizinic acid | multiple interactions | ISO | RGD:1352962 | 6480464 | NR1I2 protein affects the reaction [Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA] | CTD | PMID:22982774 |
| haloperidol | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol; more ... | CTD | PMID:12584149 |
| halothane | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Halothane | CTD | PMID:8886607 |
| hexachlorobenzene | increases expression | EXP | | 6480464 | Hexachlorobenzene results in increased expression of CYP3A2 mRNA | CTD | PMID:15159207 |
| hexaflumuron | increases expression | ISO | RGD:1352962 | 6480464 | hexafluoron results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| hydrogen peroxide | increases expression | ISO | RGD:1352962 | 6480464 | Hydrogen Peroxide results in increased expression of CYP3A4 mRNA; more ... | CTD | PMID:15056853 |
| hydroquinone | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone | CTD | PMID:21402134 |
| hyperforin | decreases activity | ISO | RGD:1352962 | 6480464 | hyperforin results in decreased activity of CYP3A4 protein | CTD | PMID:15100173 |
| hyperforin | increases expression | ISO | RGD:1352962 | 6480464 | hyperforin results in increased expression of CYP3A4 mRNA | CTD | PMID:15100173 more ... |
| hyperforin | increases expression | ISO | RGD:1352962 | 6480464 | hyperforin results in increased expression of CYP3A4 mRNA | CTD | PMID:15100173 more ... |
| hyperforin | increases expression | ISO | RGD:1352962 | 6480464 | hyperforin results in increased expression of CYP3A4 mRNA | CTD | PMID:17954527 more ... |
| hyperforin | increases expression | ISO | RGD:1352962 | 6480464 | hyperforin results in increased expression of CYP3A4 mRNA | CTD | PMID:17954527 more ... |
| hyperforin | increases expression | ISO | RGD:1352962 | 6480464 | hyperforin results in increased expression of CYP3A4 | CTD | PMID:16005588 |
| hyperforin | multiple interactions | ISO | RGD:1352962 | 6480464 | hyperforin results in increased expression of and results in increased activity of CYP3A4 protein | CTD | PMID:15100173 |
| hypericin | decreases activity | ISO | RGD:1352962 | 6480464 | hypericin results in decreased activity of CYP3A4 protein | CTD | PMID:15266218 |
| hypericin | decreases expression | ISO | RGD:1352962 | 6480464 | hypericin results in decreased expression of CYP3A4 mRNA | CTD | PMID:15266218 |
| hypericin | increases expression | ISO | RGD:1352962 | 6480464 | hypericin results in increased expression of CYP3A4 | CTD | PMID:16005588 |
| ifosfamide | affects hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the hydroxylation of Ifosfamide | CTD | PMID:12136253 |
| ifosfamide | increases expression | ISO | RGD:1352962 | 6480464 | Ifosfamide results in increased expression of CYP3A4 mRNA | CTD | PMID:18839173 |
| ifosfamide | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 results in increased susceptibility to Ifosfamide | CTD | PMID:9766669 |
| ifosfamide | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased susceptibility to Ifosfamide | CTD | PMID:20507880 |
| ifosfamide | decreases ethylation | ISO | RGD:1352962 | 6480464 | CYP3A4 gene mutant form results in decreased ethylation of Ifosfamide; more ... | CTD | PMID:15821045 |
| ifosfamide | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Ifosfamide | CTD | PMID:15875221 |
| ifosfamide | affects degradation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the degradation of Ifosfamide | CTD | PMID:12136253 |
| imipramine | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased methylation of and results in increased activity of Imipramine; more ... | CTD | PMID:15922009 |
| indoline | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of indoline | CTD | PMID:17502430 |
| isofenphos | increases expression | ISO | RGD:1352962 | 6480464 | isofenphos results in increased expression of CYP3A4 mRNA | CTD | PMID:17293382 |
| isoniazide | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased susceptibility to Isoniazid | CTD | PMID:21540358 |
| isoniazide | decreases activity | ISO | RGD:1352962 | 6480464 | Isoniazid results in decreased activity of CYP3A4 protein | CTD | PMID:15005856 PMID:15304522 |
| isoniazide | multiple interactions | EXP | | 6480464 | [SOD2 co-treated with CYP3A4] affects the susceptibility to Isoniazid | CTD | PMID:19501153 |
| isoniazide | decreases activity | ISO | RGD:1352962 | 6480464 | Isoniazid results in decreased activity of CYP3A4 protein | CTD | PMID:15304522 PMID:15005856 |
| isoprothiolane | increases expression | ISO | RGD:1352962 | 6480464 | isoprothiolane results in increased expression of CYP3A4 mRNA | CTD | PMID:17293382 |
| isotretinoin | multiple interactions | ISO | RGD:1352962 | 6480464 | Isotretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | CTD | PMID:16632523 |
| isotretinoin | increases activity | ISO | RGD:1352962 | 6480464 | Isotretinoin results in increased activity of CYP3A4 protein | CTD | PMID:16632523 |
| itraconazole | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Itraconazole | CTD | PMID:15905803 |
| itraconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Itraconazole results in decreased activity of CYP3A4 protein | CTD | PMID:15328084 more ... |
| itraconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Itraconazole results in decreased activity of CYP3A4 protein | CTD | PMID:15447735 more ... |
| itraconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Itraconazole results in decreased activity of CYP3A4 protein | CTD | PMID:15963096 more ... |
| itraconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Itraconazole results in decreased activity of CYP3A4 protein | CTD | PMID:15684493 more ... |
| itraconazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Itraconazole binds to and results in decreased activity of CYP3A4 protein | CTD | PMID:18218784 |
| itraconazole | affects activity | ISO | RGD:1352962 | 6480464 | Itraconazole affects the activity of CYP3A4 protein | CTD | PMID:15964336 |
| itraconazole | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Itraconazole | CTD | PMID:18360572 |
| itraconazole | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Itraconazole | CTD | PMID:15383492 |
| ivermectin | decreases activity | ISO | RGD:1352962 | 6480464 | Ivermectin results in decreased activity of CYP3A4 protein | CTD | PMID:11124226 |
| ivermectin | decreases activity | ISO | RGD:1352962 | 6480464 | Ivermectin results in decreased activity of CYP3A4 protein | CTD | PMID:11124226 PMID:18420780 |
| kaempferol | increases expression | ISO | RGD:1352962 | 6480464 | kaempferol results in increased expression of CYP3A4 mRNA | CTD | PMID:16442130 |
| kaempferol | decreases activity | ISO | RGD:1352962 | 6480464 | kaempferol results in decreased activity of CYP3A4 protein | CTD | PMID:15266218 PMID:21053930 |
| kaempferol | multiple interactions | ISO | RGD:1352962 | 6480464 | kaempferol inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone] | CTD | PMID:15266218 |
| kaempferol | decreases activity | ISO | RGD:1352962 | 6480464 | kaempferol results in decreased activity of CYP3A4 protein | CTD | PMID:15266218 |
| ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of CYP3A2 protein | CTD | PMID:16076768 |
| ketamine | decreases expression | ISO | RGD:1352962 | 6480464 | Ketamine results in decreased expression of CYP3A4 mRNA | CTD | PMID:18845661 |
| ketamine | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketamine results in decreased expression of and results in decreased activity of CYP3A4 protein | CTD | PMID:18845661 |
| lamotrigine | increases glutathionylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased glutathionylation of lamotrigine | CTD | PMID:19961160 |
| lansoprazole | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of lansoprazole | CTD | PMID:15010519 |
| lansoprazole | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of lansoprazole | CTD | PMID:11829200 more ... |
| lansoprazole | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of lansoprazole | CTD | PMID:7870052 more ... |
| lansoprazole | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of lansoprazole | CTD | PMID:12975331 more ... |
| lansoprazole | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of lansoprazole | CTD | PMID:8627562 PMID:12975331 |
| lansoprazole | increases expression | ISO | RGD:1352962 | 6480464 | lansoprazole results in increased expression of CYP3A4 protein | CTD | PMID:9744552 |
| lansoprazole | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of lansoprazole | CTD | PMID:12975331 PMID:8627562 |
| lansoprazole | increases expression | ISO | RGD:1352962 | 6480464 | lansoprazole results in increased expression of CYP3A4 mRNA | CTD | PMID:10859152 |
| lansoprazole | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of lansoprazole | CTD | PMID:12975331 more ... |
| lead(0) | increases expression | ISO | RGD:1352962 | 6480464 | Lead results in increased expression of CYP3A4 mRNA | CTD | PMID:19921347 |
| leflunomide | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased susceptibility to leflunomide | CTD | PMID:21540358 |
| lidocaine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Lidocaine | CTD | PMID:15447735 |
| lidocaine | multiple interactions | ISO | RGD:1352962 | 6480464 | Rifampin promotes the reaction [CYP3A4 protein results in increased metabolism of Lidocaine] | CTD | PMID:9298257 |
| lidocaine | decreases methylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased methylation of Lidocaine | CTD | PMID:15383492 |
| lidocaine | decreases ethylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased ethylation of Lidocaine | CTD | PMID:15887009 |
| limonin | decreases activity | ISO | RGD:1352962 | 6480464 | limonin results in decreased activity of CYP3A4 protein | CTD | PMID:22001672 |
| lithocholic acid | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Lithocholic Acid | CTD | PMID:15708356 |
| lithocholic acid | decreases activity | ISO | | 6480464 | Lithocholic Acid results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| lithocholic acid | increases expression | ISO | RGD:1352962 | 6480464 | Lithocholic Acid results in increased expression of CYP3A4 mRNA | CTD | PMID:17965521 PMID:20888898 |
| lithocholic acid | increases expression | EXP | | 6480464 | Lithocholic Acid results in increased expression of CYP3A2 mRNA | CTD | PMID:20006981 PMID:20888898 |
| lithocholic acid | increases expression | ISO | RGD:1352962 | 6480464 | Lithocholic Acid results in increased expression of CYP3A4 mRNA | CTD | PMID:17965521 |
| lovastatin | multiple interactions | ISO | RGD:1352962 | 6480464 | [Lovastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:17041008 |
| lovastatin | increases expression | ISO | RGD:1352962 | 6480464 | Lovastatin results in increased expression of CYP3A4 mRNA | CTD | PMID:12505310 |
| loxapine | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 results in increased metabolism of Loxapine | CTD | PMID:21826677 |
| luteolin | multiple interactions | ISO | RGD:1352962 | 6480464 | Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; more ... | CTD | PMID:18191104 |
| lycopene | increases activity | ISO | RGD:1352962 | 6480464 | lycopene results in increased activity of CYP3A4 protein | CTD | PMID:16632523 |
| madecassoside | decreases activity | ISO | RGD:1352962 | 6480464 | madecassoside results in decreased activity of CYP3A4 protein | CTD | PMID:21349323 |
| malathion | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Malathion | CTD | PMID:15557345 PMID:17110060 |
| malathion | increases expression | ISO | RGD:1352962 | 6480464 | Malathion results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| malathion | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Malathion | CTD | PMID:17110060 PMID:15557345 |
| mangiferin | decreases activity | ISO | RGD:1352962 | 6480464 | mangiferin results in decreased activity of CYP3A4 protein | CTD | PMID:22815239 |
| medroxyprogesterone acetate | increases expression | ISO | RGD:1352962 | 6480464 | Medroxyprogesterone Acetate results in increased expression of CYP3A4 mRNA; more ... | CTD | PMID:15650019 |
| mefloquine | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Mefloquine] | CTD | PMID:15896247 |
| metformin | increases expression | ISO | RGD:1352962 | 6480464 | Metformin results in increased expression of CYP3A4 mRNA | CTD | PMID:19022234 |
| metformin | multiple interactions | ISO | RGD:1352962 | 6480464 | Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; more ... | CTD | PMID:21920351 |
| metformin | decreases expression | ISO | RGD:1352962 | 6480464 | Metformin results in decreased expression of CYP3A4 mRNA | CTD | PMID:21920351 |
| methadone | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Methadone | CTD | PMID:15986265 |
| methamphetamine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Methamphetamine metabolite | CTD | PMID:16038959 |
| methamphetamine | multiple interactions | ISO | RGD:1352962 | 6480464 | [Methamphetamine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | CTD | PMID:12851153 PMID:12851153 |
| methamphetamine | multiple interactions | ISO | RGD:1352962 | 6480464 | [Methamphetamine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | CTD | PMID:12851153 |
| methotrexate | decreases expression | ISO | RGD:1352962 | 6480464 | Methotrexate results in decreased expression of CYP3A4 mRNA | CTD | PMID:16837568 |
| methoxsalen | decreases activity | EXP | | 6480464 | Methoxsalen results in decreased activity of CYP3A2 protein | CTD | PMID:15879494 |
| methoxsalen | decreases activity | ISO | RGD:1352962 | 6480464 | Methoxsalen results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| methoxsalen | multiple interactions | ISO | RGD:1352962 | 6480464 | Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA]; more ... | CTD | PMID:17003103 |
| methoxsalen | increases expression | ISO | RGD:1352962 | 6480464 | Methoxsalen results in increased expression of CYP3A4 mRNA; more ... | CTD | PMID:17003103 |
| methoxychlor | increases expression | EXP | | 6480464 | Methoxychlor results in increased expression of CYP3A2 protein | CTD | PMID:12919727 |
| methoxychlor | decreases activity | ISO | RGD:1352962 | 6480464 | Methoxychlor results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| methoxychlor | increases expression | ISO | RGD:1352962 | 6480464 | Methoxychlor results in increased expression of CYP3A4 protein | CTD | PMID:15548381 |
| methoxychlor | increases expression | ISO | RGD:1352962 | 6480464 | Methoxychlor results in increased expression of CYP3A4 mRNA | CTD | PMID:15466163 |
| metronidazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Amiodarone] | CTD | PMID:15869686 |
| metronidazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Tacrolimus] | CTD | PMID:15855244 |
| metyrapone | multiple interactions | ISO | RGD:1352962 | 6480464 | [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:17041008 |
| metyrapone | increases expression | ISO | RGD:1352962 | 6480464 | Metyrapone results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 PMID:12505310 |
| metyrapone | increases expression | ISO | RGD:1352962 | 6480464 | Metyrapone results in increased expression of CYP3A4 mRNA | CTD | PMID:12505310 PMID:10219967 |
| miconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Miconazole results in decreased activity of CYP3A4 protein | CTD | PMID:15969931 PMID:15135088 |
| miconazole | decreases activity | ISO | RGD:1352962 | 6480464 | Miconazole results in decreased activity of CYP3A4 protein | CTD | PMID:15135088 PMID:15969931 |
| mifepristone | multiple interactions | ISO | RGD:1352962 | 6480464 | Mifepristone inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | CTD | PMID:16049126 |
| mifepristone | increases expression | ISO | RGD:1352962 | 6480464 | Mifepristone results in increased expression of CYP3A4 mRNA | CTD | PMID:12235278 more ... |
| mifepristone | multiple interactions | ISO | RGD:1352962 | 6480464 | Mifepristone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; more ... | CTD | PMID:22652334 |
| mifepristone | decreases activity | ISO | RGD:1352962 | 6480464 | Mifepristone results in decreased activity of CYP3A4 protein | CTD | PMID:15860655 more ... |
| mifepristone | increases expression | ISO | RGD:1352962 | 6480464 | Mifepristone results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 more ... |
| mifepristone | increases expression | ISO | RGD:1352962 | 6480464 | Mifepristone results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 more ... |
| mifepristone | increases expression | ISO | RGD:1352962 | 6480464 | Mifepristone results in increased expression of CYP3A4 mRNA | CTD | PMID:15466163 more ... |
| mifepristone | multiple interactions | ISO | RGD:1352962 | 6480464 | NR1I2 protein promotes the reaction [Mifepristone results in increased expression of CYP3A4 mRNA] | CTD | PMID:12235278 |
| mifepristone | multiple interactions | ISO | RGD:1352962 | 6480464 | [Mifepristone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:17041008 |
| mifepristone | decreases activity | ISO | RGD:1352962 | 6480464 | Mifepristone results in decreased activity of CYP3A4 protein | CTD | PMID:15860655 PMID:16049126 |
| mifepristone | multiple interactions | ISO | RGD:1352962 | 6480464 | Mifepristone inhibits the reaction [NR3C1 protein promotes the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA]] | CTD | PMID:10219967 |
| mono(2-ethylhexyl) phthalate | increases metabolic processing | EXP | | 6480464 | CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate | CTD | PMID:22186153 |
| mono(2-ethylhexyl) phthalate | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate | CTD | PMID:22186153 |
| mono(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:1352962 | 6480464 | [Dexamethasone co-treated with mono-(2-ethylhexyl)phthalate] results in increased activity of CYP3A4 protein | CTD | PMID:18332045 |
| mono(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid | CTD | PMID:22186153 |
| mono(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid | CTD | PMID:22186153 |
| monocrotaline | multiple interactions | ISO | RGD:1619215 | 6480464 | [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein | CTD | PMID:21224054 |
| monocrotaline | multiple interactions | ISO | | 6480464 | [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein | CTD | PMID:21224054 |
| monocrotaline | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of and results in increased activity of Monocrotaline | CTD | PMID:19818743 |
| monocrotophos | multiple interactions | ISO | RGD:1352962 | 6480464 | [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein; more ... | CTD | PMID:22733800 |
| monocrotophos | increases expression | ISO | RGD:1352962 | 6480464 | Monocrotophos results in increased expression of CYP3A4 protein; more ... | CTD | PMID:22733800 |
| monocrotophos | increases activity | ISO | RGD:1352962 | 6480464 | Monocrotophos results in increased activity of CYP3A4 protein | CTD | PMID:22733800 |
| monoethylglycinexylidide | affects chemical synthesis | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the chemical synthesis of monoethylglycinexylidide | CTD | PMID:15887009 |
| moricizine | increases expression | ISO | RGD:1352962 | 6480464 | Moricizine results in increased expression of CYP3A4 mRNA | CTD | PMID:18332078 |
| mycophenolic acid | increases methylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased methylation of Mycophenolic Acid | CTD | PMID:15570183 |
| N,N-diethyl-m-toluamide | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of DEET | CTD | PMID:11854147 |
| N,N-diethyl-m-toluamide | increases expression | ISO | RGD:1352962 | 6480464 | DEET results in increased expression of CYP3A4 mRNA | CTD | PMID:19326769 |
| N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [DDT co-treated with Diethylnitrosamine] results in increased expression of CYP3A2 mRNA; more ... | CTD | PMID:15885732 |
| N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 protein | CTD | PMID:11165752 PMID:16246485 |
| N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CYP3A2 protein | CTD | PMID:9744545 |
| N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP3A2 mRNA | CTD | PMID:18164116 |
| N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 protein | CTD | PMID:16246485 PMID:11165752 |
| N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP3A2 protein | CTD | PMID:11165752 |
| N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of CYP3A2 mRNA; more ... | CTD | PMID:16246485 |
| NADP zwitterion | multiple interactions | ISO | RGD:1352962 | 6480464 | [retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein; more ... | CTD | PMID:19818743 |
| NADP zwitterion | multiple interactions | ISO | RGD:1352962 | 6480464 | [[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; more ... | CTD | PMID:21766881 |
| NADP zwitterion | multiple interactions | ISO | RGD:1352962 | 6480464 | CYB5A protein promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]; more ... | CTD | PMID:22390216 |
| NADP zwitterion | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine | CTD | PMID:20825217 |
| NADP zwitterion | multiple interactions | EXP | | 6480464 | [CYP3A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine | CTD | PMID:20825217 |
| NADP(+) | multiple interactions | ISO | RGD:1352962 | 6480464 | [[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; more ... | CTD | PMID:21766881 |
| NADP(+) | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine | CTD | PMID:20825217 |
| NADP(+) | multiple interactions | ISO | RGD:1352962 | 6480464 | CYB5A protein promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]; more ... | CTD | PMID:22390216 |
| NADP(+) | multiple interactions | EXP | | 6480464 | [CYP3A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine | CTD | PMID:20825217 |
| NADP(+) | multiple interactions | ISO | RGD:1352962 | 6480464 | [retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein; more ... | CTD | PMID:19818743 |
| naphthalene | increases expression | ISO | RGD:1352962 | 6480464 | naphthalene results in increased expression of CYP3A4 mRNA | CTD | PMID:20500019 |
| naringin | multiple interactions | ISO | RGD:1352962 | 6480464 | naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil] | CTD | PMID:16013069 |
| naringin | decreases activity | ISO | RGD:1352962 | 6480464 | naringin results in decreased activity of CYP3A4 protein | CTD | PMID:16013069 PMID:21053930 |
| naringin | decreases activity | ISO | RGD:1352962 | 6480464 | naringin results in decreased activity of CYP3A4 protein | CTD | PMID:16013069 |
| nefazodone | multiple interactions | ISO | RGD:1352962 | 6480464 | nefazodone inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | CTD | PMID:12584149 |
| nefazodone | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased susceptibility to nefazodone | CTD | PMID:21540358 |
| nemorubicin | increases metabolic processing | EXP | | 6480464 | CYP3A2 protein results in increased metabolism of methoxy-morpholinyl-doxorubicin | CTD | PMID:15465924 |
| nemorubicin | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of methoxy-morpholinyl-doxorubicin | CTD | PMID:15465924 |
| nemorubicin | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein co-treated with POR protein] results in increased metabolism of methoxy-morpholinyl-doxorubicin | CTD | PMID:15465924 |
| nevirapine | affects binding | ISO | RGD:1352962 | 6480464 | Nevirapine binds to CYP3A4 protein | CTD | PMID:22793666 |
| nifedipine | multiple interactions | EXP | | 6480464 | Nifedipine inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] | CTD | PMID:19858067 |
| nifedipine | decreases activity | ISO | | 6480464 | Nifedipine results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| nifedipine | multiple interactions | ISO | RGD:1352962 | 6480464 | [Nifedipine binds to CYP3A4 promoter] which results in decreased expression of CYP3A4 mRNA | CTD | PMID:12851153 PMID:12851153 |
| nifedipine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Nifedipine | CTD | PMID:15286053 more ... |
| nifedipine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Nifedipine | CTD | PMID:15634941 more ... |
| nifedipine | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Nifedipine | CTD | PMID:19230594 PMID:16712844 |
| nifedipine | multiple interactions | ISO | RGD:1352962 | 6480464 | YM 758 inhibits the reaction [CYP3A4 protein results in increased metabolism of Nifedipine] | CTD | PMID:19230594 |
| nifedipine | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Nifedipine | CTD | PMID:16712844 PMID:19230594 |
| nifedipine | multiple interactions | ISO | RGD:1352962 | 6480464 | [Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:17041008 |
| nifedipine | multiple interactions | EXP | | 6480464 | [SOD2 co-treated with CYP3A4] affects the susceptibility to Nifedipine | CTD | PMID:19501153 |
| nifedipine | increases expression | ISO | RGD:1352962 | 6480464 | Nifedipine results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 PMID:17954527 |
| nifedipine | multiple interactions | ISO | RGD:1352962 | 6480464 | [Nifedipine binds to CYP3A4 promoter] which results in decreased expression of CYP3A4 mRNA | CTD | PMID:12851153 |
| nifedipine | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Nifedipine | CTD | PMID:16712844 |
| nifedipine | increases oxidation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased oxidation of Nifedipine | CTD | PMID:15618748 PMID:15937564 |
| nifedipine | affects oxidation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the oxidation of Nifedipine | CTD | PMID:2271712 |
| nifedipine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Nifedipine | CTD | PMID:15634941 more ... |
| nimesulide | multiple interactions | EXP | | 6480464 | nimesulide inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein] | CTD | PMID:18079364 |
| nortriptyline | increases metabolic processing | ISO | RGD:1352962 | 6480464 | Nortriptyline results in increased metabolism of CYP3A4 protein | CTD | PMID:18359012 |
| ochratoxin A | increases expression | ISO | RGD:1352962 | 6480464 | ochratoxin A results in increased expression of CYP3A4 mRNA | CTD | PMID:21834667 |
| ochratoxin A | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased susceptibility to ochratoxin A | CTD | PMID:21781659 PMID:8542584 |
| octamethylcyclotetrasiloxane | increases expression | EXP | | 6480464 | octamethylcyclotetrasiloxane results in increased expression of CYP3A2 protein | CTD | PMID:15849718 |
| ofloxacin | multiple interactions | ISO | RGD:1352962 | 6480464 | [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline] | CTD | PMID:11408986 |
| oleanolic acid | decreases activity | ISO | RGD:1352962 | 6480464 | Oleanolic Acid results in decreased activity of CYP3A4 protein | CTD | PMID:15043991 |
| oleanolic acid | multiple interactions | ISO | RGD:1352962 | 6480464 | Oleanolic Acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | CTD | PMID:15043991 |
| omeprazole | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Omeprazole | CTD | PMID:15626586 PMID:15286053 |
| omeprazole | decreases activity | ISO | | 6480464 | Omeprazole results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| omeprazole | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Omeprazole | CTD | PMID:12485723 more ... |
| omeprazole | increases expression | ISO | RGD:1352962 | 6480464 | Omeprazole results in increased expression of CYP3A4 mRNA | CTD | PMID:12235278 more ... |
| omeprazole | increases expression | ISO | RGD:1352962 | 6480464 | Omeprazole results in increased expression of CYP3A4 mRNA | CTD | PMID:12235278 more ... |
| omeprazole | increases expression | ISO | RGD:1352962 | 6480464 | Omeprazole results in increased expression of CYP3A4 mRNA | CTD | PMID:15802389 more ... |
| omeprazole | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Omeprazole | CTD | PMID:12485723 more ... |
| omeprazole | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Omeprazole | CTD | PMID:15286053 PMID:15626586 |
| omeprazole | increases expression | ISO | RGD:1352962 | 6480464 | Omeprazole results in increased expression of CYP3A4 protein | CTD | PMID:9744552 |
| omeprazole | increases expression | ISO | RGD:1352962 | 6480464 | Omeprazole results in increased expression of CYP3A4 mRNA | CTD | PMID:17954527 more ... |
| omeprazole | multiple interactions | ISO | RGD:1352962 | 6480464 | Omeprazole results in increased expression of and results in increased activity of CYP3A4 protein | CTD | PMID:15802389 |
| omeprazole | multiple interactions | ISO | RGD:1352962 | 6480464 | [Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:17041008 |
| omeprazole | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Omeprazole | CTD | PMID:7870052 more ... |
| omeprazole | multiple interactions | ISO | RGD:1352962 | 6480464 | NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA] | CTD | PMID:12695340 |
| oxycodone | multiple interactions | EXP | | 6480464 | Oxycodone inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Testosterone] | CTD | PMID:20487198 |
| oxycodone | multiple interactions | ISO | RGD:1352962 | 6480464 | telithromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Oxycodone] | CTD | PMID:19755414 |
| oxycodone | decreases expression | EXP | | 6480464 | Oxycodone results in decreased expression of CYP3A2 mRNA; more ... | CTD | PMID:20487198 |
| paclitaxel | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Paclitaxel | CTD | PMID:15901749 |
| paclitaxel | decreases activity | ISO | RGD:1352962 | 6480464 | Paclitaxel results in decreased activity of CYP3A4 protein | CTD | PMID:19909766 |
| paclitaxel | multiple interactions | ISO | RGD:1352962 | 6480464 | Oxygen deficiency inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Paclitaxel] | CTD | PMID:19695866 |
| paclitaxel | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Paclitaxel | CTD | PMID:19695866 |
| paclitaxel | increases expression | ISO | RGD:1352962 | 6480464 | Paclitaxel results in increased expression of CYP3A4 mRNA; more ... | CTD | PMID:15650019 PMID:18839173 |
| paclitaxel | increases activity | ISO | RGD:1352962 | 6480464 | Paclitaxel results in increased activity of CYP3A4 protein | CTD | PMID:12065438 PMID:18839173 |
| paclitaxel | multiple interactions | EXP | | 6480464 | Plant Extracts inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein] | CTD | PMID:15918522 |
| paclitaxel | increases expression | EXP | | 6480464 | Paclitaxel results in increased expression of CYP3A4 protein | CTD | PMID:15918522 |
| paclitaxel | increases expression | ISO | RGD:1352962 | 6480464 | Paclitaxel results in increased expression of CYP3A4 protein; more ... | CTD | PMID:18839173 PMID:15650019 |
| paclitaxel | increases activity | ISO | RGD:1352962 | 6480464 | Paclitaxel results in increased activity of CYP3A4 protein | CTD | PMID:18839173 PMID:12065438 |
| pantoprazole | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of pantoprazole | CTD | PMID:8930576 |
| pantoprazole | increases expression | ISO | RGD:1352962 | 6480464 | pantoprazole results in increased expression of CYP3A4 protein | CTD | PMID:9744552 |
| pantoprazole | multiple interactions | ISO | RGD:1352962 | 6480464 | pantoprazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | CTD | PMID:15258107 |
| paracetamol | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 results in increased metabolism of Acetaminophen | CTD | PMID:20566340 |
| paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of CYP3A2 mRNA | CTD | PMID:17126469 PMID:21807079 |
| paracetamol | affects expression | ISO | RGD:1619215 | 6480464 | Acetaminophen affects the expression of CYP3A41A mRNA | CTD | PMID:17562736 |
| paracetamol | multiple interactions | ISO | RGD:1352962 | 6480464 | NR1I2 protein affects the reaction [CYP3A4 protein results in increased metabolism of Acetaminophen] | CTD | PMID:19460945 |
| paracetamol | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Acetaminophen | CTD | PMID:19460945 |
| paracetamol | multiple interactions | ISO | RGD:1352962 | 6480464 | Acetaminophen results in decreased degradation of and results in increased activity of CYP3A4 protein | CTD | PMID:11811955 |
| paracetamol | multiple interactions | EXP | | 6480464 | [Acetaminophen co-treated with Uranium analog] results in decreased expression of CYP3A2 mRNA | CTD | PMID:17126469 |
| paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of CYP3A2 mRNA | CTD | PMID:17126469 |
| paracetamol | multiple interactions | EXP | | 6480464 | Arsenic inhibits the reaction [Acetaminophen results in increased activity of CYP3A4 protein] | CTD | PMID:19932728 |
| paracetamol | increases activity | EXP | | 6480464 | Acetaminophen results in increased activity of CYP3A4 protein | CTD | PMID:19932728 |
| parathion | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Parathion | CTD | PMID:12669189 more ... |
| parathion | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Parathion | CTD | PMID:12669189 more ... |
| parathion | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Parathion | CTD | PMID:17079358 more ... |
| parathion | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Parathion | CTD | PMID:17110060 more ... |
| paricalcitol | increases expression | ISO | RGD:1352962 | 6480464 | paricalcitol results in increased expression of CYP3A4 mRNA | CTD | PMID:11723248 |
| pentachlorobenzene | increases oxidation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased oxidation of pentachlorobenzene | CTD | PMID:7747284 |
| pentachlorophenol | increases expression | ISO | RGD:1352962 | 6480464 | Pentachlorophenol results in increased expression of CYP3A4 protein | CTD | PMID:15548381 |
| pentamidine | decreases activity | ISO | RGD:1352962 | 6480464 | Pentamidine results in decreased activity of CYP3A4 protein | CTD | PMID:11124226 |
| perazine | decreases methylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased methylation of Perazine | CTD | PMID:11026737 |
| perfluorooctane-1-sulfonic acid | increases expression | ISO | RGD:1352962 | 6480464 | perfluorooctane sulfonic acid results in increased expression of CYP3A4 mRNA | CTD | PMID:21723365 |
| perfluorooctane-1-sulfonic acid | increases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in increased expression of CYP3A2 mRNA | CTD | PMID:16221955 more ... |
| perfluorooctane-1-sulfonic acid | increases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in increased expression of CYP3A2 mRNA | CTD | PMID:19162173 more ... |
| perfluorooctane-1-sulfonic acid | multiple interactions | ISO | RGD:1352962 | 6480464 | perfluorooctane sulfonic acid inhibits the reaction [CYP3A4 protein results in increased oxidation of Testosterone] | CTD | PMID:21964418 |
| perfluorooctane-1-sulfonic acid | increases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in increased expression of CYP3A2 mRNA | CTD | PMID:18692542 more ... |
| perfluorooctane-1-sulfonic acid | increases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in increased expression of CYP3A2 mRNA | CTD | PMID:19162173 more ... |
| perfluorooctanoic acid | decreases expression | ISO | RGD:1619215 | 6480464 | perfluorooctanoic acid results in decreased expression of CYP3A41A mRNA | CTD | PMID:17681415 |
| permethrin | multiple interactions | ISO | RGD:1352962 | 6480464 | Permethrin inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol]; more ... | CTD | PMID:16790556 |
| permethrin | increases expression | ISO | RGD:1352962 | 6480464 | Permethrin results in increased expression of CYP3A4 mRNA | CTD | PMID:19249324 PMID:19326768 |
| permethrin | increases expression | ISO | RGD:1352962 | 6480464 | Permethrin results in increased expression of CYP3A4 mRNA | CTD | PMID:19326768 PMID:19249324 |
| permethrin | decreases activity | ISO | RGD:1352962 | 6480464 | Permethrin results in decreased activity of CYP3A4 protein | CTD | PMID:16790556 |
| phenacetin | affects metabolic processing | EXP | | 6480464 | CYP3A2 protein affects the metabolism of Phenacetin | CTD | PMID:15879494 |
| phencyclidine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Phencyclidine | CTD | PMID:16782764 |
| phenethyl isothiocyanate | decreases expression | ISO | RGD:1352962 | 6480464 | phenethyl isothiocyanate results in decreased expression of CYP3A4 mRNA | CTD | PMID:20442190 |
| phenethyl isothiocyanate | increases expression | EXP | | 6480464 | phenethyl isothiocyanate results in increased expression of CYP3A4 protein | CTD | PMID:20025923 |
| phenethyl isothiocyanate | decreases expression | EXP | | 6480464 | phenethyl isothiocyanate results in decreased expression of CYP3A2 mRNA | CTD | PMID:22664424 |
| phenethyl isothiocyanate | decreases activity | EXP | | 6480464 | phenethyl isothiocyanate results in decreased activity of CYP3A2 protein | CTD | PMID:22664424 |
| phenethyl isothiocyanate | decreases activity | ISO | RGD:1352962 | 6480464 | phenethyl isothiocyanate results in decreased activity of CYP3A4 mRNA | CTD | PMID:20442190 |
| phenobarbital | multiple interactions | EXP | | 6480464 | Phenobarbital affects the expression of and affects the activity of CYP3A2 protein | CTD | PMID:12807726 |
| phenobarbital | increases expression | ISO | | 6480464 | Phenobarbital results in increased expression of CYP3A4 mRNA | CTD | PMID:19136022 |
| phenobarbital | increases expression | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 more ... |
| phenobarbital | increases expression | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased expression of CYP3A4 protein | CTD | PMID:10640517 more ... |
| phenobarbital | increases activity | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased activity of CYP3A4 mRNA | CTD | PMID:19202563 |
| phenobarbital | increases activity | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased activity of CYP3A4 protein | CTD | PMID:12065438 more ... |
| phenobarbital | decreases activity | ISO | RGD:1352962 | 6480464 | Phenobarbital results in decreased activity of CYP3A4 protein | CTD | PMID:19909766 |
| phenobarbital | affects expression | ISO | RGD:1352962 | 6480464 | Phenobarbital affects the expression of CYP3A4 mRNA | CTD | PMID:19159669 |
| phenobarbital | increases expression | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 more ... |
| phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CYP3A2 mRNA | CTD | PMID:11181506 more ... |
| phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CYP3A2 mRNA | CTD | PMID:16940010 more ... |
| phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CYP3A2 mRNA | CTD | PMID:20607812 more ... |
| phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CYP3A2 protein | CTD | PMID:10506011 more ... |
| phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CYP3A2 mRNA | CTD | PMID:19162173 more ... |
| phenobarbital | increases expression | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased expression of CYP3A4 protein | CTD | PMID:15548381 more ... |
| phenobarbital | increases expression | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased expression of CYP3A4 mRNA | CTD | PMID:17954527 more ... |
| phenobarbital | multiple interactions | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased expression of and results in increased activity of CYP3A4 protein | CTD | PMID:15833926 PMID:15802389 |
| phenobarbital | increases activity | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased activity of CYP3A4 protein | CTD | PMID:14977870 more ... |
| phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CYP3A2 mRNA | CTD | PMID:16940010 more ... |
| phenobarbital | increases expression | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased expression of CYP3A4 protein | CTD | PMID:21227907 more ... |
| phenobarbital | increases expression | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased expression of CYP3A4 mRNA | CTD | PMID:12673034 more ... |
| phenobarbital | increases activity | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased activity of CYP3A4 protein | CTD | PMID:12065438 more ... |
| phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CYP3A2 protein | CTD | PMID:15588932 more ... |
| phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CYP3A2 mRNA | CTD | PMID:19162173 more ... |
| phenobarbital | increases expression | ISO | RGD:1619215 | 6480464 | Phenobarbital results in increased expression of CYP3A4 mRNA | CTD | PMID:19136022 |
| phenobarbital | multiple interactions | ISO | RGD:1352962 | 6480464 | sodium arsenite inhibits the reaction [Phenobarbital results in increased expression of and results in increased activity of CYP3A4 protein]; more ... | CTD | PMID:15833926 |
| phenobarbital | increases expression | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased expression of CYP3A4 mRNA | CTD | PMID:12673034 more ... |
| phenobarbital | increases expression | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased expression of CYP3A4 protein | CTD | PMID:21227907 more ... |
| phenobarbital | multiple interactions | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased expression of and results in increased activity of CYP3A4 protein | CTD | PMID:15802389 PMID:15833926 |
| phenobarbital | increases activity | ISO | RGD:1352962 | 6480464 | Phenobarbital results in increased activity of CYP3A4 protein | CTD | PMID:18094037 more ... |
| phenobarbital | multiple interactions | ISO | RGD:1352962 | 6480464 | [Celsior co-treated with Phenobarbital] results in increased expression of CYP3A4 mRNA | CTD | PMID:15448115 |
| phenobarbital | multiple interactions | ISO | RGD:1352962 | 6480464 | NR3C1 protein promotes the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] | CTD | PMID:10219967 |
| phenobarbital | multiple interactions | ISO | RGD:1352962 | 6480464 | NR1I2 protein affects the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] | CTD | PMID:12695340 |
| phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of CYP3A2 | CTD | PMID:15975961 |
| phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CYP3A2 protein | CTD | PMID:15588932 more ... |
| phenobarbital | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CYP3A2 protein | CTD | PMID:9744545 |
| phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CYP3A2 mRNA | CTD | PMID:17505019 more ... |
| phenobarbital | multiple interactions | EXP | | 6480464 | Dactinomycin inhibits the reaction [Phenobarbital results in increased expression of CYP3A2 mRNA] | CTD | PMID:11181506 |
| phenthoate | increases activity | ISO | RGD:1352962 | 6480464 | phenthoate results in increased activity of CYP3A4 protein | CTD | PMID:22310298 |
| phenthoate | increases expression | ISO | RGD:1352962 | 6480464 | phenthoate results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| phenylbutazone | multiple interactions | ISO | RGD:1352962 | 6480464 | NR3C1 protein promotes the reaction [Phenylbutazone results in increased expression of CYP3A4 mRNA] | CTD | PMID:10219967 |
| phenylbutazone | increases activity | ISO | RGD:1352962 | 6480464 | Phenylbutazone results in increased activity of CYP3A4 protein | CTD | PMID:9512926 |
| phenylbutazone | increases expression | ISO | RGD:1352962 | 6480464 | Phenylbutazone results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 |
| phenytoin | multiple interactions | ISO | RGD:1352962 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] | CTD | PMID:21402137 |
| phenytoin | multiple interactions | ISO | | 6480464 | [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein | CTD | PMID:21224054 |
| phenytoin | increases expression | ISO | RGD:1352962 | 6480464 | Phenytoin results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 more ... |
| phenytoin | increases activity | ISO | RGD:1352962 | 6480464 | Phenytoin results in increased activity of CYP3A4 protein | CTD | PMID:12065438 more ... |
| phenytoin | increases activity | ISO | RGD:1352962 | 6480464 | Phenytoin results in increased activity of CYP3A4 protein | CTD | PMID:21742782 more ... |
| phenytoin | increases expression | ISO | RGD:1352962 | 6480464 | Phenytoin results in increased expression of CYP3A4 mRNA | CTD | PMID:12505310 more ... |
| phenytoin | increases expression | ISO | RGD:1352962 | 6480464 | Phenytoin results in increased expression of CYP3A4 mRNA | CTD | PMID:12695340 more ... |
| phenytoin | increases activity | ISO | RGD:1352962 | 6480464 | Phenytoin results in increased activity of CYP3A4 protein | CTD | PMID:12065438 more ... |
| phenytoin | multiple interactions | ISO | RGD:1352962 | 6480464 | NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA] | CTD | PMID:12695340 |
| phenytoin | multiple interactions | ISO | RGD:1352962 | 6480464 | NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP3A4 mRNA] | CTD | PMID:18206661 |
| phenytoin | increases expression | EXP | | 6480464 | Phenytoin results in increased expression of CYP3A2 mRNA | CTD | PMID:17505019 |
| phenytoin | multiple interactions | ISO | RGD:1619215 | 6480464 | [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein | CTD | PMID:21224054 |
| phenytoin | increases expression | ISO | RGD:1352962 | 6480464 | Phenytoin results in increased expression of CYP3A4 protein | CTD | PMID:18206661 |
| phenytoin | multiple interactions | ISO | RGD:1352962 | 6480464 | Phenytoin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol] | CTD | PMID:16207822 |
| phenytoin | increases activity | ISO | RGD:1352962 | 6480464 | Phenytoin results in increased activity of CYP3A4 protein | CTD | PMID:9512926 more ... |
| phenytoin | increases expression | ISO | RGD:1352962 | 6480464 | Phenytoin results in increased expression of CYP3A4 mRNA | CTD | PMID:12673034 more ... |
| phenytoin | multiple interactions | ISO | RGD:1352962 | 6480464 | NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA] | CTD | PMID:10219967 |
| phthalic acid | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid | CTD | PMID:22186153 |
| phthalic acid | multiple interactions | EXP | | 6480464 | [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid | CTD | PMID:22186153 |
| phthalic acid | increases expression | ISO | RGD:1352962 | 6480464 | phthalic acid results in increased expression of CYP3A4 mRNA; more ... | CTD | PMID:15650019 |
| pimobendan | decreases methylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased methylation of pimobendan | CTD | PMID:10611143 |
| pioglitazone | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of pioglitazone | CTD | PMID:15900286 |
| pioglitazone | decreases activity | ISO | RGD:1352962 | 6480464 | pioglitazone results in decreased activity of CYP3A4 protein | CTD | PMID:12642470 PMID:15860655 |
| pioglitazone | increases expression | ISO | RGD:1352962 | 6480464 | pioglitazone results in increased expression of CYP3A4 mRNA | CTD | PMID:12642470 PMID:16837568 |
| pioglitazone | multiple interactions | ISO | RGD:1352962 | 6480464 | pioglitazone results in increased expression of and results in increased activity of CYP3A4 protein | CTD | PMID:12642470 |
| pioglitazone | decreases activity | ISO | RGD:1352962 | 6480464 | pioglitazone results in decreased activity of CYP3A4 protein | CTD | PMID:15860655 PMID:12642470 |
| pioglitazone | increases expression | ISO | RGD:1352962 | 6480464 | pioglitazone results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 PMID:12642470 |
| pioglitazone | multiple interactions | EXP | | 6480464 | pioglitazone inhibits the reaction [Endotoxins results in decreased expression of CYP3A2 protein] | CTD | PMID:15364003 |
| pirinixic acid | multiple interactions | ISO | RGD:1352962 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:19710929 |
| poly(styrene) | multiple interactions | ISO | RGD:1352962 | 6480464 | styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP3A4 protein] | CTD | PMID:19909766 |
| poly(styrene) | decreases activity | ISO | RGD:1352962 | 6480464 | styrofoam analog results in decreased activity of CYP3A4 protein | CTD | PMID:19909766 |
| polymyxin B2 | multiple interactions | EXP | | 6480464 | Polymyxin B inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein] | CTD | PMID:18079364 |
| potassium hexacyanoferrate(3-) | multiple interactions | ISO | RGD:1352962 | 6480464 | potassium ferricyanide inhibits the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]]; more ... | CTD | PMID:22652334 |
| prednisolone | increases expression | ISO | RGD:1352962 | 6480464 | Prednisolone results in increased expression of CYP3A4 mRNA | CTD | PMID:12673034 |
| pregnenolone | increases expression | ISO | RGD:1352962 | 6480464 | Pregnenolone results in increased expression of CYP3A4 mRNA; more ... | CTD | PMID:15650019 |
| pregnenolone 16alpha-carbonitrile | multiple interactions | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of and results in increased activity of CYP3A2 protein | CTD | PMID:15946133 |
| pregnenolone 16alpha-carbonitrile | increases expression | ISO | RGD:1352962 | 6480464 | Pregnenolone Carbonitrile results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 more ... |
| pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of CYP3A2 mRNA | CTD | PMID:19850644 PMID:19162173 |
| pregnenolone 16alpha-carbonitrile | increases expression | ISO | RGD:1352962 | 6480464 | Pregnenolone Carbonitrile results in increased expression of CYP3A4 mRNA | CTD | PMID:15541768 more ... |
| pregnenolone 16alpha-carbonitrile | increases expression | ISO | RGD:1352962 | 6480464 | Pregnenolone Carbonitrile results in increased expression of CYP3A4 mRNA | CTD | PMID:12505310 more ... |
| pregnenolone 16alpha-carbonitrile | increases expression | ISO | RGD:1352962 | 6480464 | Pregnenolone Carbonitrile results in increased expression of CYP3A4 mRNA | CTD | PMID:12505310 more ... |
| pregnenolone 16alpha-carbonitrile | multiple interactions | ISO | RGD:1352962 | 6480464 | NR3C1 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A4 mRNA] | CTD | PMID:10219967 |
| pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of CYP3A2 protein | CTD | PMID:15588932 |
| pregnenolone 16alpha-carbonitrile | increases activity | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased activity of CYP3A2 protein | CTD | PMID:12458634 |
| pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of CYP3A2 mRNA | CTD | PMID:19162173 PMID:19850644 |
| primaquine | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Primaquine | CTD | PMID:19616568 |
| primaquine | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine | CTD | PMID:19616568 |
| probenecid | multiple interactions | ISO | RGD:1352962 | 6480464 | Probenecid promotes the reaction [CYP3A4 protein affects the chemical synthesis of carbamazepine epoxide]; more ... | CTD | PMID:15915352 |
| probenecid | decreases expression | ISO | RGD:1352962 | 6480464 | Probenecid results in decreased expression of CYP3A4 mRNA | CTD | PMID:16837568 |
| profenofos | increases expression | ISO | RGD:1352962 | 6480464 | profenofos results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| profenofos | decreases expression | EXP | | 6480464 | profenofos results in decreased expression of CYP3A2 mRNA; more ... | CTD | PMID:18828448 |
| profenofos | increases activity | ISO | RGD:1352962 | 6480464 | profenofos results in increased activity of CYP3A4 protein | CTD | PMID:22310298 |
| proguanil | decreases activity | ISO | RGD:1352962 | 6480464 | Proguanil results in decreased activity of CYP3A4 protein | CTD | PMID:11124226 |
| propiconazole | increases expression | EXP | | 6480464 | propiconazole results in increased expression of CYP3A2 mRNA | CTD | PMID:15603923 |
| propranolol | increases oxidation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased oxidation of Propranolol | CTD | PMID:19853591 |
| pyridine | multiple interactions | EXP | | 6480464 | cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA]; more ... | CTD | PMID:11181506 |
| pyridine | increases expression | EXP | | 6480464 | pyridine results in increased expression of CYP3A2 mRNA; more ... | CTD | PMID:11181506 |
| pyridine | increases activity | EXP | | 6480464 | pyridine results in increased activity of CYP3A2 protein | CTD | PMID:11181506 |
| pyrimidin-2-amine | decreases activity | ISO | RGD:1352962 | 6480464 | 2-aminopyrimidine analog results in decreased activity of CYP3A4 protein | CTD | PMID:19317514 |
| quercetin | decreases expression | ISO | | 6480464 | Quercetin results in decreased expression of CYP3A2 mRNA | CTD | PMID:16455785 |
| quercetin | decreases activity | ISO | RGD:1352962 | 6480464 | Quercetin results in decreased activity of CYP3A4 protein | CTD | PMID:15266218 more ... |
| quercetin | increases expression | ISO | RGD:1352962 | 6480464 | Quercetin results in increased expression of CYP3A4 mRNA | CTD | PMID:12695340 more ... |
| quercetin | decreases activity | ISO | RGD:1352962 | 6480464 | Quercetin results in decreased activity of CYP3A4 protein | CTD | PMID:15266218 more ... |
| quercetin | increases expression | ISO | RGD:1352962 | 6480464 | Quercetin results in increased expression of CYP3A4 mRNA | CTD | PMID:12695340 more ... |
| quercetin | decreases activity | ISO | RGD:1352962 | 6480464 | Quercetin results in decreased activity of CYP3A4 protein | CTD | PMID:19766177 PMID:15266218 |
| quercetin | increases expression | ISO | RGD:1352962 | 6480464 | Quercetin results in increased expression of CYP3A4 mRNA | CTD | PMID:16442130 more ... |
| quercetin | multiple interactions | ISO | RGD:1352962 | 6480464 | [Quercetin results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine | CTD | PMID:11502731 |
| quercetin | decreases activity | ISO | RGD:1352962 | 6480464 | Quercetin results in decreased activity of CYP3A4 protein | CTD | PMID:15266218 PMID:19766177 |
| quercetin | multiple interactions | ISO | RGD:1352962 | 6480464 | Quercetin inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone] | CTD | PMID:15266218 |
| quercetin | decreases expression | ISO | RGD:1619215 | 6480464 | Quercetin results in decreased expression of CYP3A2 mRNA | CTD | PMID:16455785 |
| quercetin | multiple interactions | ISO | RGD:1352962 | 6480464 | Quercetin inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein] | CTD | PMID:19766177 |
| quinidine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Quinidine | CTD | PMID:15784650 PMID:2271712 |
| quinidine | decreases activity | ISO | | 6480464 | Quinidine results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| quinidine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Quinidine | CTD | PMID:2271712 PMID:15784650 |
| quinidine | multiple interactions | ISO | RGD:1352962 | 6480464 | Quinidine inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758] | CTD | PMID:19230594 |
| quinine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Quinine | CTD | PMID:15896247 PMID:12920490 |
| quinine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Quinine | CTD | PMID:12920490 PMID:15896247 |
| quinine | decreases activity | ISO | RGD:1352962 | 6480464 | Quinine results in decreased activity of CYP3A4 protein | CTD | PMID:11124226 |
| raloxifene | decreases activity | ISO | RGD:1352962 | 6480464 | Raloxifene results in decreased activity of CYP3A4 protein | CTD | PMID:15860655 |
| rel-(3R,5S)-fluvastatin | multiple interactions | ISO | RGD:1352962 | 6480464 | fluvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam] | CTD | PMID:16029222 |
| rel-(3R,5S)-fluvastatin | decreases activity | ISO | RGD:1352962 | 6480464 | fluvastatin results in decreased activity of CYP3A4 protein | CTD | PMID:16029222 |
| reserpine | increases expression | ISO | RGD:1352962 | 6480464 | Reserpine results in increased expression of CYP3A4 protein | CTD | PMID:8632764 |
| reserpine | multiple interactions | ISO | RGD:1352962 | 6480464 | [Reserpine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:17041008 |
| reserpine | increases expression | ISO | RGD:1352962 | 6480464 | Reserpine results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 |
| resveratrol | increases expression | ISO | RGD:1352962 | 6480464 | resveratrol results in increased expression of CYP3A4 mRNA | CTD | PMID:17210444 |
| resveratrol | decreases activity | ISO | RGD:1352962 | 6480464 | resveratrol results in decreased activity of CYP3A4 protein | CTD | PMID:12569440 PMID:18420780 |
| resveratrol | decreases activity | ISO | RGD:1352962 | 6480464 | resveratrol results in decreased activity of CYP3A4 protein | CTD | PMID:12569440 |
| resveratrol | multiple interactions | ISO | RGD:1352962 | 6480464 | resveratrol inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone] | CTD | PMID:12569440 |
| resveratrol | multiple interactions | ISO | RGD:1352962 | 6480464 | resveratrol inhibits the reaction [CYP3A4 protein results in increased metabolism of Buspirone] | CTD | PMID:20716633 |
| riddelliine | decreases expression | EXP | | 6480464 | riddelliine results in decreased expression of CYP3A2 mRNA | CTD | PMID:18047727 |
| rifabutin | increases expression | ISO | RGD:1352962 | 6480464 | Rifabutin results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 |
| rifabutin | multiple interactions | ISO | RGD:1352962 | 6480464 | AADAC mRNA affects the reaction [Rifabutin results in increased expression of CYP3A4 mRNA] | CTD | PMID:21856291 |
| rifabutin | increases expression | ISO | RGD:1352962 | 6480464 | Rifabutin results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 PMID:21856291 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein] | CTD | PMID:16146350 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | sulforafan inhibits the reaction [Rifampin results in increased expression of CYP3A4] | CTD | PMID:23153560 |
| rifampicin | increases expression | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of CYP3A4 | CTD | PMID:15554232 PMID:23153560 |
| rifampicin | increases expression | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 more ... |
| rifampicin | increases activity | ISO | RGD:1352962 | 6480464 | Rifampin results in increased activity of CYP3A4 protein | CTD | PMID:12065438 more ... |
| rifampicin | increases expression | EXP | | 6480464 | Rifampin results in increased expression of CYP3A2 mRNA | CTD | PMID:22159698 |
| rifampicin | multiple interactions | EXP | | 6480464 | arsenite inhibits the reaction [Rifampin results in increased expression of CYP3A2 mRNA]; more ... | CTD | PMID:22159698 |
| rifampicin | increases expression | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 more ... |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | [Rifampin binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | CTD | PMID:12851153 PMID:12851153 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 mRNA; more ... | CTD | PMID:22733800 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; more ... | CTD | PMID:21402137 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | AADAC mRNA affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | CTD | PMID:21856291 |
| rifampicin | increases activity | ISO | RGD:1352962 | 6480464 | Rifampin results in increased activity of CYP3A4 protein | CTD | PMID:12065438 more ... |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA | CTD | PMID:20361990 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Dichlororibofuranosylbenzimidazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | CTD | PMID:17003103 |
| rifampicin | increases activity | ISO | | 6480464 | Rifampin results in increased activity of CYP3A4 protein | CTD | PMID:20361990 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of and results in increased activity of CYP3A4 protein | CTD | PMID:14709624 more ... |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:17041008 PMID:21127053 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | CTD | PMID:12695340 more ... |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | [NR1I2 protein co-treated with Rifampin] results in decreased expression of CYP3A4 mRNA | CTD | PMID:21764778 |
| rifampicin | multiple interactions | ISO | | 6480464 | NR1I2 affects the reaction [Rifampin results in increased activity of CYP3A4 protein] | CTD | PMID:20361990 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | sodium arsenite inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | CTD | PMID:15833926 PMID:22310326 |
| rifampicin | multiple interactions | ISO | | 6480464 | [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein | CTD | PMID:21224054 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | CTD | PMID:12417264 more ... |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Rifampin promotes the reaction [NR1I2 protein binds to CYP3A4 promoter] | CTD | PMID:21641981 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Rifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP3A4 mRNA]; more ... | CTD | PMID:21292004 |
| rifampicin | increases expression | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 more ... |
| rifampicin | increases expression | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of CYP3A4 protein | CTD | PMID:10640517 more ... |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | CTD | PMID:17003103 PMID:21127053 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; more ... | CTD | PMID:21920351 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Dexamethasone promotes the reaction [Rifampin results in increased activity of CYP3A4 protein] | CTD | PMID:18332045 |
| rifampicin | increases expression | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of CYP3A4 protein | CTD | PMID:10640517 more ... |
| rifampicin | increases expression | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of CYP3A4 mRNA | CTD | PMID:15802389 more ... |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of and results in increased activity of CYP3A4 protein | CTD | PMID:15769886 more ... |
| rifampicin | increases activity | ISO | RGD:1352962 | 6480464 | Rifampin results in increased activity of CYP3A4 protein | CTD | PMID:9512926 more ... |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | CTD | PMID:21742782 PMID:12695340 |
| rifampicin | increases expression | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of CYP3A4 mRNA | CTD | PMID:15802389 more ... |
| rifampicin | increases expression | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of CYP3A4 protein | CTD | PMID:8632764 more ... |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of and results in increased activity of CYP3A4 protein | CTD | PMID:14709624 more ... |
| rifampicin | increases activity | ISO | RGD:1352962 | 6480464 | Rifampin results in increased activity of CYP3A4 protein | CTD | PMID:15771232 more ... |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | CTD | PMID:12695340 PMID:21742782 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Calcitriol promotes the reaction [Rifampin results in increased activity of CYP3A4 protein]; more ... | CTD | PMID:21742782 |
| rifampicin | multiple interactions | ISO | RGD:1619215 | 6480464 | [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein | CTD | PMID:21224054 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | sodium arsenite inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; more ... | CTD | PMID:15833926 |
| rifampicin | increases expression | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of CYP3A4 protein | CTD | PMID:14636322 more ... |
| rifampicin | increases expression | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 more ... |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of and results in increased activity of CYP3A4 protein | CTD | PMID:15802389 more ... |
| rifampicin | increases expression | ISO | RGD:1352962 | 6480464 | Rifampin results in increased expression of CYP3A4 | CTD | PMID:15554232 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:17041008 |
| rifampicin | increases activity | ISO | RGD:1352962 | 6480464 | Rifampin results in increased activity of CYP3A4 protein | CTD | PMID:9298257 more ... |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Rifampin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | CTD | PMID:16632523 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] | CTD | PMID:12417264 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Rifampin promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] | CTD | PMID:11581012 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | Rifampin promotes the reaction [CYP3A4 protein results in increased metabolism of Lidocaine] | CTD | PMID:9298257 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | [Rifampin binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA | CTD | PMID:12851153 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | NR3C1 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | CTD | PMID:10219967 |
| rifampicin | affects activity | ISO | RGD:1352962 | 6480464 | Rifampin affects the activity of CYP3A4 protein | CTD | PMID:15964336 |
| rifampicin | multiple interactions | ISO | RGD:1352962 | 6480464 | NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA] | CTD | PMID:12695340 |
| rifapentine | increases expression | ISO | RGD:1352962 | 6480464 | rifapentine results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 |
| rifapentine | multiple interactions | ISO | RGD:1352962 | 6480464 | AADAC mRNA affects the reaction [rifapentine results in increased expression of CYP3A4 mRNA] | CTD | PMID:21856291 |
| rifapentine | increases expression | ISO | RGD:1352962 | 6480464 | rifapentine results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 PMID:21856291 |
| risperidone | multiple interactions | ISO | RGD:1352962 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] | CTD | PMID:21402137 |
| romidepsin | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of romidepsin | CTD | PMID:15635176 |
| rose bengal | decreases activity | ISO | RGD:1352962 | 6480464 | Rose Bengal results in decreased activity of CYP3A4 protein | CTD | PMID:20041016 |
| rosiglitazone | multiple interactions | ISO | RGD:1352962 | 6480464 | rosiglitazone results in increased expression of and results in increased activity of CYP3A4 protein | CTD | PMID:12642470 |
| rosiglitazone | decreases activity | ISO | RGD:1352962 | 6480464 | rosiglitazone results in decreased activity of CYP3A4 protein | CTD | PMID:12642470 PMID:15860655 |
| rosiglitazone | increases expression | ISO | RGD:1352962 | 6480464 | rosiglitazone results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 PMID:12642470 |
| rosiglitazone | increases expression | ISO | RGD:1352962 | 6480464 | rosiglitazone results in increased expression of CYP3A4 mRNA | CTD | PMID:12642470 PMID:16837568 |
| rosiglitazone | decreases activity | ISO | RGD:1352962 | 6480464 | rosiglitazone results in decreased activity of CYP3A4 protein | CTD | PMID:15860655 PMID:12642470 |
| saquinavir | multiple interactions | ISO | RGD:1352962 | 6480464 | Glutathione inhibits the reaction [Saquinavir results in decreased activity of CYP3A4 protein] | CTD | PMID:15523003 |
| saquinavir | decreases activity | ISO | RGD:1352962 | 6480464 | Saquinavir results in decreased activity of CYP3A4 protein | CTD | PMID:15523003 |
| selenium atom | decreases expression | ISO | RGD:1352962 | 6480464 | Selenium results in decreased expression of CYP3A4 mRNA | CTD | PMID:19244175 |
| semicarbazide | increases activity | EXP | | 6480464 | carbamylhydrazine results in increased activity of CYP3A2 protein | CTD | PMID:19788891 |
| semicarbazide | multiple interactions | EXP | | 6480464 | [carbamylhydrazine results in increased activity of CYP3A2 protein] which results in increased abundance of Testosterone metabolite | CTD | PMID:19788891 |
| sertraline | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased amination of and results in increased metabolism of Sertraline; more ... | CTD | PMID:15547048 |
| sevoflurane | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of sevoflurane | CTD | PMID:7879937 |
| silibinin | decreases activity | ISO | RGD:1352962 | 6480464 | silybin results in decreased activity of CYP3A4 protein | CTD | PMID:15155549 |
| silibinin | multiple interactions | ISO | RGD:1352962 | 6480464 | silybin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | CTD | PMID:15155549 |
| simvastatin | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Simvastatin | CTD | PMID:16011971 |
| simvastatin | affects response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 polymorphism affects the susceptibility to Simvastatin | CTD | PMID:15650881 PMID:19802823 |
| simvastatin | affects response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 polymorphism affects the susceptibility to Simvastatin | CTD | PMID:19802823 PMID:15650881 |
| simvastatin | multiple interactions | ISO | RGD:1352962 | 6480464 | ABCB1 alternative form affects the reaction [CYP3A4 polymorphism affects the susceptibility to Simvastatin] | CTD | PMID:19802823 |
| simvastatin | increases expression | ISO | RGD:1352962 | 6480464 | Simvastatin results in increased expression of CYP3A4 mRNA | CTD | PMID:12505310 |
| simvastatin | multiple interactions | ISO | RGD:1352962 | 6480464 | [Simvastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:17041008 |
| sirolimus | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Sirolimus | CTD | PMID:15707415 PMID:15964407 |
| sirolimus | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein polymorphism affects the metabolism of Sirolimus | CTD | PMID:15707415 |
| sodium cholate | multiple interactions | EXP | | 6480464 | [1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A2 protein | CTD | PMID:1627548 |
| sodium cholate | multiple interactions | ISO | RGD:1352962 | 6480464 | [1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A4 protein | CTD | PMID:1627548 |
| spironolactone | increases expression | ISO | RGD:1352962 | 6480464 | Spironolactone results in increased expression of CYP3A4 mRNA | CTD | PMID:12505310 |
| staurosporine | multiple interactions | ISO | RGD:1352962 | 6480464 | Staurosporine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] | CTD | PMID:17965521 |
| sterigmatocystin | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Sterigmatocystin | CTD | PMID:2271712 PMID:2655891 |
| sterigmatocystin | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased glutathionylation of and results in increased hydroxylation of Sterigmatocystin] which results in increased chemical synthesis of Sterigmatocystin metabolite | CTD | PMID:20929267 |
| sterigmatocystin | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Sterigmatocystin | CTD | PMID:2655891 PMID:2271712 |
| styrene | multiple interactions | EXP | | 6480464 | gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 mRNA]; more ... | CTD | PMID:18202523 |
| styrene | increases expression | EXP | | 6480464 | Styrene results in increased expression of CYP3A2 protein | CTD | PMID:18202523 |
| Sudan I | increases oxidation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol | CTD | PMID:19358889 PMID:17159775 |
| Sudan I | multiple interactions | ISO | RGD:1352962 | 6480464 | CYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol] | CTD | PMID:17159775 PMID:19358889 |
| Sudan I | multiple interactions | ISO | RGD:1352962 | 6480464 | CYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol] | CTD | PMID:19358889 PMID:17159775 |
| Sudan I | increases oxidation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol | CTD | PMID:17159775 PMID:19358889 |
| sulfamethazine | increases activity | ISO | RGD:1352962 | 6480464 | Sulfamethazine results in increased activity of CYP3A4 protein | CTD | PMID:12065438 |
| sulfamethoxazole | multiple interactions | EXP | | 6480464 | [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole | CTD | PMID:19501153 |
| sulfinpyrazone | increases expression | ISO | RGD:1352962 | 6480464 | Sulfinpyrazone results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 more ... |
| sulfinpyrazone | increases expression | ISO | RGD:1352962 | 6480464 | Sulfinpyrazone results in increased expression of CYP3A4 mRNA | CTD | PMID:10219967 more ... |
| sulfinpyrazone | increases activity | ISO | RGD:1352962 | 6480464 | Sulfinpyrazone results in increased activity of CYP3A4 protein | CTD | PMID:12065438 PMID:9512926 |
| sulfinpyrazone | increases expression | ISO | RGD:1352962 | 6480464 | Sulfinpyrazone results in increased expression of CYP3A4 mRNA | CTD | PMID:17954527 more ... |
| sulfinpyrazone | increases expression | ISO | RGD:1352962 | 6480464 | Sulfinpyrazone results in increased expression of CYP3A4 mRNA | CTD | PMID:16837568 more ... |
| sulfinpyrazone | increases activity | ISO | RGD:1352962 | 6480464 | Sulfinpyrazone results in increased activity of CYP3A4 protein | CTD | PMID:9512926 PMID:12065438 |
| sulforaphane | multiple interactions | EXP | | 6480464 | sulforafan results in decreased expression of and results in decreased activity of CYP3A2 protein | CTD | PMID:15906351 |
| sulforaphane | multiple interactions | ISO | RGD:1352962 | 6480464 | sulforafan inhibits the reaction [Rifampin results in increased expression of CYP3A4] | CTD | PMID:23153560 |
| sulforaphane | decreases activity | EXP | | 6480464 | sulforafan results in decreased activity of CYP3A2 protein | CTD | PMID:22664424 |
| sulforaphane | decreases expression | ISO | RGD:1352962 | 6480464 | sulforafan results in decreased expression of CYP3A4 mRNA | CTD | PMID:20442190 |
| sulforaphane | increases expression | EXP | | 6480464 | sulforafan results in increased expression of CYP3A2 protein | CTD | PMID:18823965 |
| tacrine | increases expression | EXP | | 6480464 | Tacrine analog results in increased expression of CYP3A2 protein; more ... | CTD | PMID:20533758 |
| tacrine | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased susceptibility to Tacrine | CTD | PMID:21540358 |
| tacrolimus hydrate | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Tacrolimus | CTD | PMID:15010519 more ... |
| tacrolimus hydrate | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Tacrolimus | CTD | PMID:15919446 more ... |
| tacrolimus hydrate | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Tacrolimus | CTD | PMID:15964336 more ... |
| tacrolimus hydrate | decreases methylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased methylation of Tacrolimus | CTD | PMID:15951320 |
| tacrolimus hydrate | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Tacrolimus | CTD | PMID:15855244 |
| tacrolimus hydrate | multiple interactions | ISO | RGD:1352962 | 6480464 | Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Tacrolimus] | CTD | PMID:15855244 |
| tamoxifen | increases hydroxylation | EXP | | 6480464 | CYP3A2 protein results in increased hydroxylation of Tamoxifen | CTD | PMID:15587933 |
| tamoxifen | decreases activity | ISO | | 6480464 | Tamoxifen results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| tamoxifen | multiple interactions | ISO | RGD:1352962 | 6480464 | [Troleandomycin results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Tamoxifen | CTD | PMID:14652237 |
| tamoxifen | increases expression | ISO | RGD:1352962 | 6480464 | Tamoxifen results in increased expression of CYP3A4 mRNA | CTD | PMID:18839173 |
| tamoxifen | decreases activity | ISO | RGD:1352962 | 6480464 | Tamoxifen results in decreased activity of CYP3A4 protein | CTD | PMID:12419016 |
| tamoxifen | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 4-hydroxytamoxifen | CTD | PMID:20507880 |
| tamoxifen | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Tamoxifen | CTD | PMID:20507880 |
| tamoxifen | multiple interactions | EXP | | 6480464 | Tamoxifen promotes the reaction [testosterone enanthate results in increased expression of CYP3A2 protein] | CTD | PMID:8573203 |
| tebufenozide | increases expression | ISO | RGD:1352962 | 6480464 | tebufenozide results in increased expression of CYP3A4 mRNA | CTD | PMID:22310298 |
| testosterone | increases hydroxylation | EXP | | 6480464 | CYP3A2 protein results in increased hydroxylation of Testosterone | CTD | PMID:20487198 |
| testosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | fipronil promotes the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone] | CTD | PMID:17084830 |
| testosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone | CTD | PMID:17084830 PMID:19135037 |
| testosterone | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Testosterone | CTD | PMID:12401345 more ... |
| testosterone | decreases activity | ISO | | 6480464 | Testosterone results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| testosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]; more ... | CTD | PMID:12569440 |
| testosterone | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Testosterone | CTD | PMID:12433797 more ... |
| testosterone | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Testosterone | CTD | PMID:12818727 more ... |
| testosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | Amiodarone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; more ... | CTD | PMID:22652334 |
| testosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | Oxygen deficiency inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | CTD | PMID:19695866 |
| testosterone | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Testosterone | CTD | PMID:12401345 more ... |
| testosterone | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Testosterone | CTD | PMID:17418993 more ... |
| testosterone | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Testosterone | CTD | PMID:12433797 more ... |
| testosterone | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Testosterone | CTD | PMID:15626586 more ... |
| testosterone | multiple interactions | EXP | | 6480464 | [carbamylhydrazine results in increased activity of CYP3A2 protein] which results in increased abundance of Testosterone metabolite | CTD | PMID:19788891 |
| testosterone | decreases expression | ISO | RGD:1619215 | 6480464 | Testosterone results in decreased expression of CYP3A41A mRNA | CTD | PMID:20844152 PMID:21669218 |
| testosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | perfluorooctane sulfonic acid inhibits the reaction [CYP3A4 protein results in increased oxidation of Testosterone] | CTD | PMID:21964418 |
| testosterone | increases oxidation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased oxidation of Testosterone | CTD | PMID:21964418 |
| testosterone | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Testosterone | CTD | PMID:17565714 more ... |
| testosterone | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Testosterone | CTD | PMID:15499178 more ... |
| testosterone | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Testosterone | CTD | PMID:15626586 more ... |
| testosterone | decreases expression | ISO | RGD:1619215 | 6480464 | Testosterone results in decreased expression of CYP3A41A mRNA | CTD | PMID:21669218 PMID:20844152 |
| testosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | Testosterone inhibits the reaction [Ethinyl Estradiol results in decreased activity of CYP3A4 protein] | CTD | PMID:11907170 |
| testosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | silybin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] | CTD | PMID:15155549 |
| testosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone] | CTD | PMID:11377097 |
| testosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone | CTD | PMID:19135037 |
| testosterone | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Testosterone | CTD | PMID:12401345 more ... |
| testosterone | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Testosterone | CTD | PMID:12433797 more ... |
| testosterone | increases hydrolysis | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydrolysis of Testosterone | CTD | PMID:11377097 |
| testosterone | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Testosterone | CTD | PMID:15548719 more ... |
| testosterone | affects hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the hydroxylation of Testosterone | CTD | PMID:2271712 |
| testosterone | multiple interactions | EXP | | 6480464 | Oxycodone inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Testosterone] | CTD | PMID:20487198 |
| testosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | Carbofuran promotes the reaction [CYP3A4 protein affects the metabolism of Testosterone] | CTD | PMID:15560889 |
| testosterone | multiple interactions | ISO | RGD:1352962 | 6480464 | Azithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; more ... | CTD | PMID:16416302 |
| testosterone enanthate | multiple interactions | EXP | | 6480464 | Tamoxifen promotes the reaction [testosterone enanthate results in increased expression of CYP3A2 protein] | CTD | PMID:8573203 |
| testosterone enanthate | increases expression | EXP | | 6480464 | testosterone enanthate results in increased expression of CYP3A2 protein | CTD | PMID:8573203 |
| tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of CYP3A2 protein | CTD | PMID:17606319 PMID:10445401 |
| tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of CYP3A4 mRNA | CTD | PMID:19224547 |
| tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of CYP3A2 protein | CTD | PMID:10445401 PMID:17606319 |
| tetrachloromethane | increases metabolic processing | EXP | | 6480464 | CYP3A2 protein results in increased metabolism of Carbon Tetrachloride | CTD | PMID:15988118 |
| tetrachloromethane | decreases activity | EXP | | 6480464 | Carbon Tetrachloride results in decreased activity of CYP3A2 protein | CTD | PMID:14706259 |
| tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of CYP3A2 mRNA | CTD | PMID:14706259 |
| tetracycline | decreases expression | EXP | | 6480464 | Tetracycline results in decreased expression of CYP3A4 mRNA | CTD | PMID:19224547 |
| tetramethrin | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of tetramethrin | CTD | PMID:19249324 |
| thalidomide | multiple interactions | ISO | RGD:1352962 | 6480464 | [CYP3A4 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide | CTD | PMID:20443640 |
| thalidomide | increases hydroxylation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased hydroxylation of Thalidomide | CTD | PMID:20443640 |
| theophylline | multiple interactions | ISO | RGD:1352962 | 6480464 | [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline] | CTD | PMID:11408986 |
| thiabendazole | increases expression | ISO | RGD:1352962 | 6480464 | Thiabendazole results in increased expression of CYP3A4 mRNA | CTD | PMID:18570159 |
| thioridazine | decreases activity | ISO | RGD:1352962 | 6480464 | Thioridazine results in decreased activity of CYP3A4 protein | CTD | PMID:15135088 |
| ticlopidine | increases degradation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased degradation of Ticlopidine | CTD | PMID:22651985 |
| ticlopidine | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine]; more ... | CTD | PMID:22651985 |
| ticlopidine | multiple interactions | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite | CTD | PMID:19170597 |
| ticlopidine | increases response to substance | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased susceptibility to Ticlopidine | CTD | PMID:22651985 |
| toluene | multiple interactions | EXP | | 6480464 | 1-Butanol promotes the reaction [Toluene results in increased expression of CYP3A2 mRNA] | CTD | PMID:17209515 |
| toluene | increases expression | EXP | | 6480464 | Toluene results in increased expression of CYP3A2 mRNA | CTD | PMID:17209515 |
| topiramate | increases activity | ISO | RGD:1352962 | 6480464 | topiramate results in increased activity of CYP3A4 protein | CTD | PMID:14636322 |
| topiramate | increases expression | ISO | RGD:1352962 | 6480464 | topiramate results in increased expression of CYP3A4 mRNA; more ... | CTD | PMID:14636322 |
| trans-1,2-dichloroethene | decreases activity | EXP | | 6480464 | 1,2-dichloroethylene results in decreased activity of CYP3A2 protein | CTD | PMID:9493318 |
| trans-1,2-dichloroethene | decreases expression | EXP | | 6480464 | 1,2-dichloroethylene results in decreased expression of CYP3A2 protein | CTD | PMID:9493318 |
| trans-resveratrol | increases expression | ISO | RGD:1352962 | 6480464 | resveratrol results in increased expression of CYP3A4 mRNA | CTD | PMID:17210444 |
| trans-resveratrol | decreases activity | ISO | RGD:1352962 | 6480464 | resveratrol results in decreased activity of CYP3A4 protein | CTD | PMID:12569440 PMID:18420780 |
| trans-resveratrol | multiple interactions | ISO | RGD:1352962 | 6480464 | resveratrol inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone] | CTD | PMID:12569440 |
| trans-resveratrol | decreases activity | ISO | RGD:1352962 | 6480464 | resveratrol results in decreased activity of CYP3A4 protein | CTD | PMID:12569440 |
| trans-resveratrol | multiple interactions | ISO | RGD:1352962 | 6480464 | resveratrol inhibits the reaction [CYP3A4 protein results in increased metabolism of Buspirone] | CTD | PMID:20716633 |
| trazodone | multiple interactions | ISO | RGD:1352962 | 6480464 | Trazodone inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] | CTD | PMID:12584149 |
| trazodone | multiple interactions | EXP | | 6480464 | [SOD2 co-treated with CYP3A4] affects the susceptibility to Trazodone | CTD | PMID:19501153 |
| triazolam | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Triazolam | CTD | PMID:15286053 PMID:16042670 |
| triazolam | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Triazolam | CTD | PMID:16042670 PMID:15286053 |
| triazolam | multiple interactions | ISO | RGD:1352962 | 6480464 | Nicardipine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Triazolam] | CTD | PMID:15863898 |
| triazolam | multiple interactions | ISO | RGD:1352962 | 6480464 | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Triazolam] | CTD | PMID:10952769 |
| triclosan | increases expression | EXP | | 6480464 | Triclosan results in increased expression of CYP3A2 mRNA | CTD | PMID:22659317 |
| troglitazone | decreases activity | ISO | RGD:1352962 | 6480464 | troglitazone results in decreased activity of CYP3A4 protein | CTD | PMID:15860655 PMID:12642470 |
| troglitazone | increases expression | ISO | RGD:1352962 | 6480464 | troglitazone results in increased expression of CYP3A4 mRNA | CTD | PMID:10752642 more ... |
| troglitazone | increases expression | ISO | RGD:1352962 | 6480464 | troglitazone results in increased expression of CYP3A4 mRNA | CTD | PMID:12505310 more ... |
| troglitazone | increases expression | ISO | RGD:1352962 | 6480464 | troglitazone results in increased expression of CYP3A4 mRNA | CTD | PMID:12642470 more ... |
| troglitazone | decreases activity | ISO | RGD:1352962 | 6480464 | troglitazone results in decreased activity of CYP3A4 protein | CTD | PMID:12642470 PMID:15860655 |
| troglitazone | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of troglitazone | CTD | PMID:19356091 |
| troglitazone | multiple interactions | ISO | RGD:1352962 | 6480464 | [troglitazone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | CTD | PMID:17041008 |
| troglitazone | increases activity | ISO | RGD:1352962 | 6480464 | troglitazone results in increased activity of CYP3A4 protein | CTD | PMID:10752642 |
| troglitazone | multiple interactions | EXP | | 6480464 | [SOD2 co-treated with CYP3A4] affects the susceptibility to troglitazone | CTD | PMID:19501153 |
| troglitazone | increases expression | ISO | RGD:1352962 | 6480464 | troglitazone results in increased expression of CYP3A4 protein | CTD | PMID:10752642 |
| troglitazone | increases expression | ISO | RGD:1352962 | 6480464 | troglitazone results in increased expression of CYP3A4 mRNA | CTD | PMID:12642470 more ... |
| troglitazone | multiple interactions | ISO | RGD:1352962 | 6480464 | troglitazone results in increased expression of and results in increased activity of CYP3A4 protein | CTD | PMID:12642470 |
| uranium atom | multiple interactions | EXP | | 6480464 | [Acetaminophen co-treated with Uranium analog] results in decreased expression of CYP3A2 mRNA | CTD | PMID:17126469 |
| uranium atom | increases expression | EXP | | 6480464 | Uranium results in increased expression of CYP3A2 mRNA | CTD | PMID:16039771 |
| ursodeoxycholic acid | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Ursodeoxycholic Acid | CTD | PMID:15708356 |
| ursodeoxycholic acid | increases expression | ISO | RGD:1352962 | 6480464 | Ursodeoxycholic Acid results in increased expression of CYP3A4 mRNA | CTD | PMID:16678547 |
| ursodeoxycholic acid | increases expression | EXP | | 6480464 | Ursodeoxycholic Acid results in increased expression of CYP3A2 mRNA | CTD | PMID:19255942 |
| ursodeoxycholic acid | multiple interactions | EXP | | 6480464 | Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of CYP3A2 mRNA]; more ... | CTD | PMID:10453939 |
| vanoxerine dihydrochloride | decreases degradation | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in decreased degradation of vanoxerine | CTD | PMID:11502731 |
| vanoxerine dihydrochloride | multiple interactions | ISO | RGD:1352962 | 6480464 | [Quercetin results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine; more ... | CTD | PMID:11502731 |
| verapamil | multiple interactions | ISO | RGD:1352962 | 6480464 | naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil] | CTD | PMID:16013069 |
| verapamil | decreases activity | ISO | | 6480464 | Verapamil results in decreased activity of CYP3A4 protein | CTD | PMID:18420780 |
| verapamil | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Verapamil | CTD | PMID:15286053 more ... |
| verapamil | decreases activity | ISO | RGD:1352962 | 6480464 | Verapamil results in decreased activity of CYP3A4 protein | CTD | PMID:15860655 PMID:15689501 |
| verapamil | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Verapamil | CTD | PMID:15692829 more ... |
| verapamil | decreases activity | ISO | RGD:1352962 | 6480464 | Verapamil results in decreased activity of CYP3A4 protein | CTD | PMID:15689501 PMID:15860655 |
| verapamil | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein affects the metabolism of Verapamil | CTD | PMID:15692829 more ... |
| vincristine | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of Vincristine | CTD | PMID:19346885 |
| yohimbine | affects metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 gene polymorphism affects the metabolism of Yohimbine | CTD | PMID:15289791 |
| zafirlukast | multiple interactions | ISO | RGD:1352962 | 6480464 | zafirlukast inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] | CTD | PMID:15370959 |
| zafirlukast | decreases activity | ISO | RGD:1352962 | 6480464 | zafirlukast results in decreased activity of CYP3A4 protein | CTD | PMID:15370959 |
| zafirlukast | decreases activity | ISO | RGD:1352962 | 6480464 | zafirlukast metabolite results in decreased activity of CYP3A4 protein | CTD | PMID:16167835 |
| zafirlukast | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of zafirlukast | CTD | PMID:16167835 |
| zearalenone | increases expression | ISO | RGD:1352962 | 6480464 | Zearalenone results in increased expression of CYP3A4 mRNA | CTD | PMID:15569515 |
| zearalenone | increases expression | EXP | | 6480464 | Zearalenone results in increased expression of CYP3A2 mRNA | CTD | PMID:20607812 |
| zidovudine | multiple interactions | EXP | | 6480464 | [SOD2 co-treated with CYP3A4] affects the susceptibility to Zidovudine | CTD | PMID:19501153 |
| zinc atom | decreases expression | EXP | | 6480464 | Zinc deficiency results in decreased expression of CYP3A2 mRNA | CTD | PMID:11705462 |
| zinc(0) | decreases expression | EXP | | 6480464 | Zinc deficiency results in decreased expression of CYP3A2 mRNA | CTD | PMID:11705462 |
| zolpidem | increases metabolic processing | ISO | RGD:1352962 | 6480464 | CYP3A4 protein results in increased metabolism of zolpidem | CTD | PMID:16449812 |