RETINOL METABOLIC PATHWAY (PW:0000141)

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Description

Animal species cannot synthesize retinol or vitamin A. They derive it from diet as provitamin carotenoids found in plants and best exemplified by beta-carotene or as preformed vitamin such as the retinyl esters found in animal food. The provitamin carotenoid is absorbed into the small intestine by passive absorption or via transport by members of the scavenger receptor family, such as Scrba1, also known as SR-BI, and Cd36. In the lumen, retinyl esters are hydrolyzed by enzymes secreted by the pa

Pathway Diagram:

Ariadne Genomics Inc. retinal retinyl esters carotenoids carotenoids/beta-carotene re-esterifed retinol cell_retinol circ_retinol NADP+ NADPH all-trans-retinol retinyl esters ---> all-trans-retinol diet carotenoids ---> carotenoids/beta-carotene Scarb1 passive diffusion Lrat Bcmo1 Cd36 cell_retinol ---> circ_retinol Akr1b10 retinal ---> cell_retinol NADPH ---> NADP+ carotenoids/beta-carotene ---> retinal Plb1 Pnlip all-trans-retinol ---> cell_retinol cell_retinol ---> re-esterifed retinol Rbp2 cell_retinol ---- Rbp2 Abca1 Pnliprp2
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Genes in Pathway:

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retinol metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:6484679
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide JBrowse link 2 243,702,035 243,720,063 RGD:6907045
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide JBrowse link 2 243,728,500 243,740,907 RGD:6907045
G Adh6 alcohol dehydrogenase 6 (class V) JBrowse link 2 243,656,568 243,687,857 RGD:6907045
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide JBrowse link 2 243,500,540 243,516,865 RGD:6907045
G Akr1b10 aldo-keto reductase family 1 member B10 JBrowse link 4 61,813,265 61,830,371 RGD:6903952
RGD:6903957
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 JBrowse link 1 238,222,689 238,264,381 RGD:10402751
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 JBrowse link 8 77,640,234 77,719,488 RGD:1576367
RGD:6907045
RGD:10402751
G Awat1 acyl-CoA wax alcohol acyltransferase 1 JBrowse link X 70,408,124 70,414,369 RGD:10402751
G Awat2 acyl-CoA wax alcohol acyltransferase 2 JBrowse link X 70,224,761 70,233,021 RGD:6907045
G Bco1 beta-carotene oxygenase 1 JBrowse link 19 49,637,059 49,673,577 RGD:6484679
RGD:6903956
RGD:6907045
RGD:10402751
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6484679
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6907045
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6907045
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 JBrowse link 1 256,382,861 256,386,729 RGD:6907045
RGD:10402751
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 JBrowse link 4 116,261,796 116,278,615 RGD:6907045
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 JBrowse link 1 256,369,410 256,380,649 RGD:6907045
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 JBrowse link 1 83,711,223 83,725,222 RGD:6907045
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 JBrowse link 1 83,744,229 83,766,490 RGD:6907045
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 JBrowse link 1 83,653,248 83,662,118 RGD:6907045
RGD:10402751
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6907045
G Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 JBrowse link 1 83,511,167 83,522,965 RGD:6907045
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 JBrowse link 1 83,103,925 83,119,578 RGD:6907045
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 JBrowse link 1 83,389,783 83,418,613 RGD:6907045
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6907045
RGD:10402751
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 JBrowse link 1 257,676,172 258,004,428 RGD:6907045
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 JBrowse link 1 258,709,726 258,766,873 RGD:6907045
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 JBrowse link 1 258,796,624 258,877,023 RGD:6907045
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 JBrowse link 1 259,257,658 259,297,270 RGD:6907045
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 JBrowse link 1 263,778,510 263,803,166 RGD:6907045
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 JBrowse link 1 147,422,999 148,119,979 RGD:6907045
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 JBrowse link 12 10,636,294 10,684,273 RGD:6907045
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 JBrowse link 12 11,641,500 11,677,818 RGD:6907045
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 JBrowse link 12 11,053,888 11,082,742 RGD:6907045
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6907045
RGD:10402751
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 JBrowse link 5 134,492,734 134,507,158 RGD:6907045
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 JBrowse link 5 134,196,910 134,207,888 RGD:6907045
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 JBrowse link 5 134,468,666 134,484,851 RGD:6907045
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 JBrowse link 5 133,978,953 134,008,255 RGD:6907045
G Dgat1 diacylglycerol O-acyltransferase 1 JBrowse link 7 117,566,363 117,576,735 RGD:6907045
RGD:10402751
G Dhrs3 dehydrogenase/reductase 3 JBrowse link 5 162,809,090 162,843,385 RGD:6907045
RGD:10402751
G Dhrs4 dehydrogenase/reductase 4 JBrowse link 15 34,155,043 34,167,073 RGD:6907045
RGD:10402751
G Dhrs9 dehydrogenase/reductase 9 JBrowse link 3 55,623,671 55,645,883 RGD:6907045
RGD:10402751
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 JBrowse link 11 81,741,342 81,757,806 RGD:10402751
G Erp29 endoplasmic reticulum protein 29 JBrowse link 12 40,619,377 40,625,884 RGD:10402751
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link 7 27,226,570 27,240,533 RGD:10402751
G Hspa5 heat shock protein family A member 5 JBrowse link 3 13,838,304 13,842,763 RGD:10402751
G Hyou1 hypoxia up-regulated 1 JBrowse link 8 48,699,796 48,711,912 RGD:10402751
G Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) JBrowse link 2 181,896,304 181,905,366 RGD:6484679
RGD:6907045
RGD:10402751
G Pdia2 protein disulfide isomerase family A, member 2 RGD:10402751
G Pdia4 protein disulfide isomerase family A, member 4 JBrowse link 4 77,470,636 77,489,535 RGD:10402751
G Pdia6 protein disulfide isomerase family A, member 6 JBrowse link 6 42,568,269 42,585,654 RGD:10402751
G Plb1 phospholipase B1 JBrowse link 6 25,375,699 25,507,108 RGD:6484679
RGD:6903951
G Pnlip pancreatic lipase JBrowse link 1 279,798,187 279,811,372 RGD:6484679
G Pnliprp2 pancreatic lipase related protein 2 JBrowse link 1 279,896,973 279,927,600 RGD:6484679
G Ppib peptidylprolyl isomerase B JBrowse link 8 71,719,681 71,725,538 RGD:10402751
G Rbp2 retinol binding protein 2 JBrowse link 8 106,479,253 106,527,726 RGD:6484679
G Rdh10 retinol dehydrogenase 10 JBrowse link 5 2,605,265 2,631,905 RGD:6907045
G Rdh11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) JBrowse link 6 102,356,498 102,372,618 RGD:6907045
RGD:10402751
G Rdh12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) JBrowse link 6 102,392,828 102,405,750 RGD:6907045
RGD:10402751
G Rdh16 retinol dehydrogenase 16 (all-trans) JBrowse link 7 71,058,150 71,072,685 RGD:10402751
G Rdh5 retinol dehydrogenase 5 JBrowse link 7 3,335,681 3,342,573 RGD:6907045
G Rdh7 retinol dehydrogenase 7 JBrowse link 7 71,125,358 71,164,014 RGD:6907045
G Rdh8 retinol dehydrogenase 8 (all-trans) JBrowse link 8 21,835,065 21,842,374 RGD:6907045
RGD:10402751
G Retsat retinol saturase JBrowse link 4 100,465,365 100,474,128 RGD:6907045
RGD:10402751
G RGD1562200 similar to GS2 gene JBrowse link X 45,519,406 45,522,988 RGD:6907045
RGD:10402751
G Rpe65 RPE65, retinoid isomerohydrolase JBrowse link 2 266,141,581 266,169,197 RGD:6907045
RGD:10402751
G Scarb1 scavenger receptor class B, member 1 JBrowse link 12 36,694,952 36,761,445 RGD:6484679
G Sdf2l1 stromal cell-derived factor 2-like 1 JBrowse link 11 88,122,271 88,124,513 RGD:10402751
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:6907045
RGD:10402751
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:6907045
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 JBrowse link 9 95,274,707 95,302,822 RGD:6907045
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 JBrowse link 9 95,256,628 95,302,822 RGD:6907045
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:6907045
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C JBrowse link 9 95,233,957 95,302,822 RGD:6907045
G Ugt1a8 UDP glycosyltransferase 1 family, polypeptide A8 JBrowse link 9 95,221,474 95,302,822 RGD:6907045
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:6907045
G Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 JBrowse link 14 22,192,970 22,217,094 RGD:6907045
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 JBrowse link 14 22,251,507 22,267,899 RGD:6907045
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B RGD:6907045
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 JBrowse link 14 22,724,399 22,736,148 RGD:6907045
G Ugt2b37 UDP-glucuronosyltransferase 2 family, member 37 JBrowse link 14 22,495,084 22,534,865 RGD:6907045

Pathway Gene Annotations

Disease Annotations Associated with Genes in the retinol metabolic pathway
Disease TermsGene Symbols
Abortion, SpontaneousCyp1a1 , Sdf2l1
Acute Kidney InjuryCyp1a1 , Cyp1a2 , Cyp2c11 , Cyp3a23/3a1 , Ugt1a1 , Ugt1a9
Acute Lung InjuryCd36 , Cyp1a1 , Cyp2b1
AdenocarcinomaCyp26a1 , Ugt2b17
Adenocarcinoma of LungErp29
Adenoma, Liver CellCyp3a23/3a1
Adenomatous Polyposis ColiCyp26a1
AlcoholismAdh5
Alzheimer DiseaseAbca1 , Cd36
Amaurosis Congenita of Leber, Type 2Rpe65
Anemia, Sickle CellCd36
Anxiety DisordersCyp3a2
Arrhythmias, CardiacCd36
ArteriosclerosisCd36
ArteritisCyp1a1
Arthritis, PsoriaticCyp1a1
Arthritis, ReactiveCyp1a1
Arthritis, RheumatoidHspa5 , Plb1
AsbestosisHspa5
AsthmaAdh5 , Cyp1a1
AtherosclerosisAbca1 , Cd36
Atrial FibrillationCd36
AtrophyCyp1a2
Barrett EsophagusCyp26a1
Behcet SyndromeCyp1a1
Birth WeightCyp1a1
BlindnessRpe65
Blood Platelet DisordersCd36
BradycardiaCyp1a1
Brain IschemiaCd36
Brain NeoplasmsCyp2c11
Breast NeoplasmsCyp1a1 , Cyp1a2 , Cyp2b1 , Cyp3a18 , Cyp3a2 , Hspa5 , Ugt1a1
BronchitisCyp1a1
Bronchitis, ChronicCyp1a1
CarcinomaScarb1
Carcinoma, Basal CellRpe65
Carcinoma, Ductal, BreastLrat
Carcinoma, HepatocellularAbca1 , Akr1b10 , Cyp1a1 , Erp29 , Hspa5
Carcinoma, Non-Small-Cell LungUgt1a1
Carcinoma, Renal CellAldh1a1 , Cyp1a1 , Scarb1
Carcinoma, Small CellUgt1a1
Carcinoma, Squamous CellCyp1a2 , Rpe65
CardiomegalyCd36 , Cyp1a1 , Cyp2c11 , Cyp4a3
CardiomyopathiesCd36 , Cyp2c11 , Dgat1
Cardiomyopathy, DilatedCd36
Cardiomyopathy, HypertrophicCd36
Cerebral HemorrhageCd36
Cerebral InfarctionCd36
Chemotherapy-Induced Febrile NeutropeniaCyp3a9
CholangiocarcinomaUgt1a9
CholecystolithiasisUgt1a1
CholelithiasisUgt1a1
CholestasisAdh5 , Cyp2b1 , Cyp2b3
ClubfootCyp1a1
Cocaine-Related DisordersScarb1
ColitisCd36 , Cyp1a1
Colonic NeoplasmsCyp26a1
Colorectal NeoplasmsAbca1 , Akr1b10 , Cyp1a2
Colorectal Neoplasms, Hereditary NonpolyposisCyp2a3
Congenital AbnormalitiesRdh5
Corneal NeovascularizationCd36
Coronary Artery DiseaseAbca1
Coronary DiseaseAbca1 , Cd36 , Scarb1
Coumarin ResistanceCyp2a3 , Cyp2c11
Coumarin SensitivityCyp2a3 , Cyp2c11
Creutzfeldt-Jakob SyndromeAldh1a1
Crigler Najjar Syndrome, Type 2Ugt1a1 , Ugt1a9
Crigler-Najjar SyndromeUgt1a1 , Ugt1a9
Crohn DiseaseUgt1a1
Cystic FibrosisCyp1a1
Depressive DisorderCyp1a2 , Cyp2b1 , Cyp2c11 , Cyp3a23/3a1
Dermatitis, Allergic ContactCd36 , Cyp1a1
Dermatitis, ContactAkr1b10 , Cyp1a1 , Ugt1a1
DermatomyositisCd36
Diabetes ComplicationsCyp2c11
Diabetes MellitusCd36 , Cyp1a1
Diabetes Mellitus, ExperimentalCd36 , Cyp1a1 , Cyp2b1 , Cyp2b3 , Rpe65 , Ugt2b17
Diabetes Mellitus, Type 1Cd36 , Ugt1a1
Diabetes Mellitus, Type 2Abca1 , Cd36 , Cyp1a1 , Cyp1a2 , Cyp3a2 , Cyp3a23/3a1 , Sdf2l1 , Ugt1a1 , Ugt1a6 , Ugt1a7c
Diabetic NephropathiesCd36 , Hspa5
Diarrhea 7Dgat1
DiGeorge SyndromeAldh1a2
Digestive System NeoplasmsCyp1a1
Dopamine Beta Hydroxylase DeficiencyHspa5
Drug EruptionsCyp1a1
Drug HypersensitivityCyp2c11
Drug-induced leukopeniaCyp3a9
Drug-Induced Liver InjuryCyp2a3 , Cyp2c11 , Cyp3a23/3a1 , Lrat , Ugt1a9
Drug-induced NeutropeniaCyp3a9 , Ugt1a1
Drug-Related Side Effects and Adverse ReactionsCyp1a2 , Cyp2b3 , Cyp2c11 , Ugt1a1
Dyskinesia, Drug-InducedCyp1a2
Endometrial NeoplasmsAkr1b10 , Cyp1a1 , Ugt1a1
EndometriosisCd36 , Cyp1a1 , Cyp26a1
Esophageal NeoplasmsAdh7 , Cyp26a1
Esophageal Squamous Cell CarcinomaHspa5
Eye Diseases, HereditaryLrat , Rpe65
Familial HDL DeficiencyAbca1
Fatty LiverAbca1 , Cd36 , Hspa5
Fatty Liver, AlcoholicCd36
Fetal Growth RetardationCyp1a1
Focal Facial Dermal Dysplasia 4Cyp26c1
Follicular CystScarb1
Fundus AlbipunctatusRdh5
Gallbladder NeoplasmsCyp1a1
GallstonesUgt1a1
Genital Neoplasms, FemaleUgt1a1
Gilbert DiseaseUgt1a1 , Ugt1a9
GliomaCyp2b1 , Hspa5
GliosarcomaCyp2b3
Glomerulonephritis, MembranousAbca1
Glucose IntoleranceCd36
Graft vs Host DiseaseUgt2b17
Gram-Negative Bacterial InfectionsUgt1a1
Granulomatosis with PolyangiitisCd36
Graves DiseaseCyp1a1
Growth DisordersCyp1a2
HamartomaCyp1a1
Heart DiseasesCyp1a1
Hematologic DiseasesUgt1a1
Hematologic NeoplasmsHspa5
HematomaCd36
Hemolytic-Uremic SyndromeCd36
HemorrhageCyp2c11
Hepatitis CCyp2b1 , Cyp3a18 , Scarb1
HepatomegalyCyp1a2
High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6Scarb1
HIV InfectionsPpib
Hodgkin DiseaseUgt1a1
HyperbilirubinemiaUgt1a1 , Ugt1a9
Hyperbilirubinemia, NeonatalUgt1a1
Hyperbilirubinemia, Transient Familial NeonatalUgt1a1 , Ugt1a9
Hypercarotenemia and Vitamin A Deficiency, Autosomal DominantBco1
HypercholesterolemiaAbca1 , Cd36 , Scarb1
Hypercholesterolemia, FamilialAbca1
HyperlipidemiasAbca1
Hyperlipoproteinemia Type IIAbca1
HyperoxiaCyp1a1
Hyperoxic Lung InjuryCyp1a1
HypersensitivityCyp1a1
HypertensionCd36 , Cyp1a1 , Cyp2c11 , Cyp4a1 , Cyp4a8
Hypertension, EssentialCyp3a9
Hypertension, PulmonaryAdh5
HyperthyroidismUgt1a1
HypertriglyceridemiaDgat1
HypoalphalipoproteinemiasAbca1
HypolipoproteinemiasAbca1
HypospadiasCyp1a1
Ichthyosis, X-LinkedRGD1562200
Immunologic Deficiency SyndromesCd36
Infarction, Middle Cerebral ArteryCd36
Infertility, FemaleHspa5
Infertility, MaleCyp1a1
InflammationCd36 , Cyp1a1 , Cyp2b1 , Cyp2b2 , Cyp3a2 , Cyp3a23/3a1 , Ugt1a1
Inflammatory Bowel DiseasesHspa5
Insulin ResistanceCd36
Ischemic Attack, TransientHspa5
JaundiceCyp1a1 , Cyp1a2
KernicterusUgt1a1
Kidney DiseasesCyp3a9
Kidney Failure, ChronicAbca1 , Cyp1a1 , Cyp2b3 , Cyp2c11 , Cyp3a2 , Scarb1
Kidney NeoplasmsCyp1a1
Laryngeal NeoplasmsAdh7
Leber Congenital AmaurosisLrat , Rpe65
Leber Congenital Amaurosis 13Rdh12
Leber Congenital Amaurosis 14Lrat
Leber Congenital Amaurosis 3Rdh12
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveCd36 , Cyp1a1 , Cyp3a9 , Hspa5
Leukemia, MyeloidUgt1a1
Leukemia, Myeloid, AcuteCyp1a1
Leukemia, Myeloid, Chronic-PhaseCyp3a9
Liver CirrhosisCd36 , Dgat1
Liver Cirrhosis, ExperimentalAdh4 , Aldh1a1 , Cd36 , Cyp1a2 , Cyp26a1 , Cyp2a2 , Cyp2c11 , Cyp3a9 , Dhrs3 , Lrat , Rdh10 , Ugt2b
Liver DiseasesCyp1a2
Liver InjuryCyp1a2
Liver Neoplasms, ExperimentalCyp1a1 , Cyp1a2
Long QT SyndromeCyp1a1
Lung InjuryCyp1a1 , Cyp1a2
Lung NeoplasmsCyp1a1 , Cyp1a2 , Ugt2b17
Lupus Erythematosus, SystemicCyp1a1
Macular DegenerationCd36
MalariaCd36
Malaria, CerebralCd36
Malformations of Cortical Development, Group IIRGD1562200
Mammary Neoplasms, AnimalScarb1
Mammary Neoplasms, ExperimentalScarb1
Marijuana AbuseScarb1
MelanomaAkr1b10
MeningomyeloceleAldh1a2
Metabolic Syndrome XAbca1 , Cd36 , Dgat1
MethemoglobinemiaCyp1a2
Micronuclei, Chromosome-DefectiveCyp1a1
Microphthalmia, Syndromic 1Cyp26c1
Mouth DiseasesCyp26b1
Mouth NeoplasmsAdh7
Multiple MyelomaCyp1a1
Multiple Sclerosis, Relapsing-RemittingCd36
Mycobacterium InfectionsCd36
Myeloproliferative DisordersCd36 , Hspa5
Myocardial InfarctionCd36 , Hspa5
Myocardial IschemiaCd36
Myocardial Reperfusion InjuryHspa5
Myocarditis, Autoimmune, ExperimentalHspa5
MyopiaRdh5
Myositis, Inclusion BodyCd36
NecrosisCyp2b1
Nematode InfectionsCyp1a1
Neoplasm InvasivenessAkr1b10
Neoplasm MetastasisErp29
NeoplasmsAkr1b10
NephritisCyp1a1
Nephritis, InterstitialCyp2c11
NephrosisCd36 , Cyp3a18 , Cyp3a9
Nephrotic SyndromeDgat1
Nerve DegenerationHspa5
Nervous System DiseasesCyp2c11
Neural Tube DefectsCyp1a2
Neuronal Ceroid-LipofuscinosesHspa5
Neurotoxicity SyndromesCyp3a9
NeutropeniaUgt1a1
Night BlindnessRdh5
Non-alcoholic Fatty Liver DiseaseCd36 , Scarb1
ObesityAbca1 , Cd36 , Cyp26b1 , Cyp2b1 , Dgat1 , Hspa5 , Pnlip
Occupational DiseasesCyp1a1
Optic Atrophy, Hereditary, LeberLrat , Rdh12 , Rpe65
OsteoarthritisAldh1a2 , Cd36
Osteoarthritis, KneeCd36
Osteogenesis ImperfectaPpib
Osteogenesis Imperfecta, Type IXPpib
OsteosarcomaCyp3a18
Ovarian NeoplasmsCyp1a2 , Ugt1a1
Pancreatic Lipase DeficiencyPnlip
Pancreatic NeoplasmsAldh1a1 , Cyp2b1 , Ugt1a7c
Pancreatitis, AlcoholicUgt1a7c
Pancreatitis, Experimental, Acute Hspa5
Parkinson DiseaseCyp1a1
Parkinsonian DisordersAldh1a1 , Aldh1a2 , Cyp1a1
PemphigusCd36
Peptic Ulcer HemorrhageCyp2c11
Peripheral Nerve InjuriesHspa5
Peripheral Nervous System DiseasesAbca1
Peripheral Vascular DiseasesCyp1a1
Pharyngeal NeoplasmsAdh7
Phencyclidine AbuseScarb1
Plasmodium Falciparum Blood Infection LevelCd36
Platelet Glycoprotein IV DeficiencyCd36
PneumoniaCyp1a1
Polycystic Kidney, Autosomal RecessiveCyp4a1 , Cyp4a2 , Cyp4a3 , Cyp4a8
Polycystic Ovary SyndromeCd36 , Cyp1a1
Polycythemia VeraCd36
Porphyria Cutanea TardaCyp1a1 , Cyp1a2
Precursor B-Cell Lymphoblastic Leukemia-LymphomaCyp3a9
Precursor Cell Lymphoblastic Leukemia-LymphomaCyp1a1 , Cyp1a2 , Cyp3a9
Prostate Cancer, FamilialCyp3a2
Prostatic NeoplasmsAldh1a2 , Cyp1a1 , Cyp3a18 , Cyp3a9 , Erp29 , Hsp90b1 , Plb1 , Sdf2l1 , Ugt2b17
PsoriasisCyp1a1
Pulmonary Disease, Chronic ObstructiveCyp1a1 , Cyp1a2
Pulmonary FibrosisCd36 , Hspa5
Purpura, Thrombotic ThrombocytopenicCd36
Radiohumeral Fusions with Other Skeletal and Craniofacial AnomaliesCyp26b1
Renal Insufficiency, ChronicDgat1
Reperfusion InjuryCd36 , Cyp1a1 , Cyp3a9 , Hspa5
Respiratory HypersensitivityHspa5
Retinal DegenerationRdh12 , Rpe65
Retinal DystrophiesLrat , Rdh12 , Rdh5 , Rpe65
RETINAL DYSTROPHY, JUVENILE CATARACTS, AND SHORT STATURE SYNDROMERdh11
Retinitis PigmentosaLrat , Rdh12 , Rpe65
Retinitis Pigmentosa 20Rpe65
Retroperitoneal FibrosisCd36
Rheumatic Heart DiseaseCd36
SchizophreniaAbca1 , RGD1562200
SeizuresCd36 , Hspa5
SepsisCd36 , Cyp1a1 , Cyp1a2 , Cyp2b1
SilicosisCd36
Simpson-Golabi-Behmel SyndromeRetsat
Sjogren's SyndromeCyp1a1
Spinal Cord InjuriesHspa5
Spinal Cord Reperfusion InjuryHspa5
Spinal DysraphismCyp26a1
Spinocerebellar Ataxia 17Hspa5 , Hyou1
Splenic DiseasesCyp1a2
SplenomegalyCyp1a2
Spondylitis, AnkylosingCyp1a1
Staphylococcal InfectionsCd36
StarvationUgt1a1
TachycardiaCd36
Tachycardia, SinusCyp1a1
Tangier DiseaseAbca1
Thrombocythemia, EssentialCd36
ThrombosisCyp3a9
Tobacco Addiction, Susceptibility ToCyp2b3
Torsades de PointesCyp3a18
Urinary Bladder NeoplasmsCyp1a1 , Cyp2c11
Uveitis, Autoimmune, ExperimentalRpe65
Vitamin A DeficiencyLrat
Warfarin SensitivityCyp2a3 , Cyp2c11
Weight GainCd36
Wounds, PenetratingCd36
Pathway Annotations Associated with Genes in the retinol metabolic pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayCyp2b3
alpha-linoleic acid metabolic pathwayPlb1
altered retinoid cycle metabolic pathwayLrat , Rdh12 , Rpe65
altered reverse cholesterol transport pathwayAbca1
antigen processing and presentation pathwayHspa5
antipyrine drug pathwayCyp2b3
arachidonic acid metabolic pathwayCyp2b1 , Cyp2b12 , Cyp2b2 , Cyp2b21 , Cyp2b3 , Cyp2c11 , Cyp2c12 , Cyp2c13 , Cyp2c22 , Cyp2c23 , Cyp2c7 , Cyp4a1 , Cyp4a2 , Cyp4a3 , Cyp4a8 , Plb1
arginine and proline metabolic pathwayAldh1a1
artemether pharmacokinetics pathwayCyp3a9 , Ugt1a9
ascorbate and aldarate metabolic pathwayAldh1a1 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
beta-alanine metabolic pathwayAldh1a1
bile acid transport pathwayScarb1
caffeine metabolic pathwayCyp1a2 , Cyp2a1 , Cyp2a2 , Cyp2a3
caffeine pharmacokinetics pathwayCyp1a2 , Cyp2c11
carbamazepine pharmacokinetics pathwayCyp2b3 , Cyp3a9
celecoxib pharmacodynamics pathwayCyp2b3 , Cyp2c11
celecoxib pharmacokinetics pathwayCyp2c11
cell-extracellular matrix signaling pathwayCd36
clomipramine pharmacokinetics pathwayCyp1a2
clopidogrel pharmacodynamics pathwayCyp1a2 , Cyp2b3 , Cyp2c11 , Cyp3a9
clopidogrel pharmacokinetics pathwayCyp1a2 , Cyp2b3 , Cyp2c11 , Cyp3a9
codeine and morphine pharmacodynamics pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
codeine and morphine pharmacokinetics pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
cyclophosphamide pharmacodynamics pathwayAldh1a1 , Cyp2b3 , Cyp2c11
cyclophosphamide pharmacokinetics pathwayAldh1a1 , Cyp2b3 , Cyp2c11
cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolismCyp2b12 , Cyp4a1 , Cyp4a2 , Cyp4a3
diclofenac pharmacodynamics pathwayCyp2b3
diflunisal pharmacodynamics pathwayCyp2b3
doxepin pharmacokinetics pathwayCyp1a2 , Cyp2c11
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaCd36 , Cyp4a1 , Cyp4a2 , Cyp4a3 , Cyp4a8
Endoplasmic Reticulum-associated degradation pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia4 , Pdia6
ether lipid metabolic pathwayPlb1
ether lipid metabolic pathwayPlb1
etodolac pharmacodynamics pathwayCyp2b3
etoposide pharmacodynamics pathwayCyp3a9 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
etoposide pharmacokinetics pathwayCyp3a9 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
fatty acid metabolic pathwayAdh4 , Adh5 , Adh6 , Adh7 , Aldh1a1 , Cyp4a1 , Cyp4a2 , Cyp4a3 , Cyp4a8
fenoprofen pharmacodynamics pathwayCyp2b3
fluoxetine pharmacodynamics pathwayCyp2c11 , Cyp3a9
fluoxetine pharmacokinetics pathwayCyp2c11 , Cyp3a9
flurbiprofen pharmacodynamics pathwayCyp2b3
gluconeogenesis pathwayAdh4 , Adh5 , Adh6 , Adh7 , Aldh1a1
glycerolipid metabolic pathwayAldh1a1 , Dgat1 , Pnlip , Pnliprp2
glycerophospholipid metabolic pathwayPlb1
glycolysis pathwayAdh4 , Adh5 , Adh6 , Adh7 , Aldh1a1
glycolysis/gluconeogenesis pathwayAdh4 , Adh5 , Adh6 , Adh7 , Aldh1a1
hepatitis C virus infection pathwayScarb1
histidine metabolic pathwayAldh1a1
ibuprofen pharmacodynamics pathwayCyp2b3 , Cyp2c11 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
ibuprofen pharmacokinetics pathwayCyp2c11 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
ifosfamide pharmacodynamics pathwayAldh1a1 , Cyp2b3 , Cyp2c11 , Cyp3a9
ifosfamide pharmacokinetics pathwayAldh1a1 , Cyp2b3 , Cyp2c11 , Cyp3a9
imipramine pharmacodynamics pathwayCyp1a2
imipramine pharmacokinetics pathwayCyp1a2
indometacin pharmacodynamics pathwayCyp2b3
indometacin pharmacodynamics pathwayCyp2b3
interleukin-6 signaling pathwayHsp90b1
irinotecan pharmacodynamics pathwayCyp3a9 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
irinotecan pharmacokinetics pathwayCyp3a9 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
ketoprofen pharmacodynamics pathwayCyp2b3
ketorolac pharmacodynamics pathwayCyp2b3
leukotriene C4 synthase deficiency pathwayCyp2b3
lidocaine pharmacodynamics pathwayCyp1a2
lidocaine pharmacokinetics pathwayCyp1a2
linoleic acid metabolic pathwayCyp1a2 , Cyp2c11 , Cyp2c12 , Cyp2c13 , Cyp2c22 , Cyp2c23 , Cyp2c7 , Cyp3a18 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9 , Cyp4a1 , Cyp4a2 , Cyp4a3 , Plb1
lornoxicam pharmacodynamics pathwayCyp2b3
lysine degradation pathwayAldh1a1
magnesium salicylate pharmacodynamics pathwayCyp2b3
mefenamic acid pharmacodynamics pathwayCyp2b3
meloxicam pharmacodynamics pathwayCyp2b3
methadone pharmacodynamics pathwayCyp2b3
methadone pharmacokinetics pathwayCyp2b3
mycophenolic acid pharmacokinetics pathwayCyp3a9 , Ugt1a9
nabumetone pharmacodynamics pathwayCyp2b3
naproxen pharmacodynamics pathwayCyp2b3
neviparine pharmacokinetics pathwayAldh1a1 , Cyp2b3 , Cyp2c11 , Cyp3a9
nicotine pharmacodynamics pathwayCyp2b3 , Ugt1a9
nicotine pharmacokinetics pathwayCyp2b3 , Ugt1a9
NOD-like receptor signaling pathwayHsp90b1
O-linked glycan biosynthetic pathwayUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
paracetamol drug pathwayCyp2b3
paracetamol pharmacokinetics pathwayCyp1a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a6 , Ugt1a9
pentose and glucuronate interconversion pathwayAldh1a1 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
phagocytosis pathwayCd36 , Scarb1
phase I biotransformation pathway via cytochrome P450Adh4 , Adh5 , Adh6 , Adh7 , Cyp1a1 , Cyp1a2 , Cyp2a1 , Cyp2a2 , Cyp2a3 , Cyp2b1 , Cyp2b12 , Cyp2b2 , Cyp2b21 , Cyp2b3 , Cyp2c11 , Cyp2c12 , Cyp2c13 , Cyp2c22 , Cyp2c23 , Cyp2c7 , Cyp3a18 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
phenytoin pharmacodynamics pathwayCyp1a2 , Cyp2c11 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
piroxicam pharmacodynamics pathwayCyp2b3
Plasmodium infection pathwayCd36
porphyrin and chlorophyll metabolic pathwayUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
prion diseases pathwayHspa5
propanoate metabolic pathwayAldh1a1
prostate cancer pathwayHsp90b1
pyruvate metabolic pathwayAldh1a1
retinitis pigmentosa pathwayLrat , Rdh12 , Rpe65
retinoic acid metabolic pathwayAldh1a1 , Aldh1a2 , Cyp26a1 , Cyp26b1 , Cyp26c1 , Dhrs9 , Lrat , Rdh10 , Rdh16 , Rdh7
retinoid cycle metabolic pathwayLrat , Rdh10 , Rdh11 , Rdh12 , Rdh5 , Rdh8 , Rpe65
retinol metabolic pathwayAbca1 , Adh4 , Adh5 , Adh6 , Adh7 , Akr1b10 , Aldh1a1 , Aldh1a2 , Awat1 , Awat2 , Bco1 , Cd36 , Cyp1a1 , Cyp1a2 , Cyp26a1 , Cyp26b1 , Cyp26c1 , Cyp2a1 , Cyp2a2 , Cyp2a3 , Cyp2b1 , Cyp2b12 , Cyp2b2 , Cyp2b21 , Cyp2b3 , Cyp2c11 , Cyp2c12 , Cyp2c13 , Cyp2c22 , Cyp2c23 , Cyp2c7 , Cyp3a18 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9 , Cyp4a1 , Cyp4a2 , Cyp4a3 , Cyp4a8 , Dgat1 , Dhrs3 , Dhrs4 , Dhrs9 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Lrat , Pdia2 , Pdia4 , Pdia6 , Plb1 , Pnlip , Pnliprp2 , Ppib , Rbp2 , Rdh10 , Rdh11 , Rdh12 , Rdh16 , Rdh5 , Rdh7 , Rdh8 , Retsat , RGD1562200 , Rpe65 , Scarb1 , Sdf2l1 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
reverse cholesterol transport pathwayAbca1 , Scarb1
rosiglitazone pharmacokinetics pathwayCyp2c11
salicylic acid pharmacodynamics pathwayCyp2b3
sodium salicylate pharmacodynamics pathwayCyp2b3
sorafenib pharmacokinetics pathwayCyp2b3 , Cyp2c11 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
starch and sucrose metabolic pathwayUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
steroid hormone biosynthetic pathwayCyp1a1 , Cyp3a18 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
sulindac pharmacodynamics pathwayCyp2b3
syndecan signaling pathwayPpib
tamoxifen pharmacodynamics pathwayCyp2b3 , Cyp3a9
tamoxifen pharmacokinetics pathwayCyp2b3 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9
teniposide pharmacodynamics pathwayCyp3a9
teniposide pharmacokinetics pathwayCyp3a9
tenoxicam pharmacodynamics pathwayCyp2b3
tiaprofenic acid pharmacodynamics pathwayCyp2b3
tolmetin pharmacodynamics pathwayCyp2b3
tramadol pharmacokinetics pathwayCyp2b3
triacylglycerol metabolic pathwayDgat1
tryptophan metabolic pathwayAldh1a1 , Cyp1a1 , Cyp1a2
tyrosine metabolic pathwayAdh4 , Adh5 , Adh6 , Adh7
valdecoxib pharmacodynamics pathwayCyp2b3
valine, leucine and isoleucine degradation pathwayAldh1a1
valproic acid pharmacokinetics pathwayCyp2b3 , Cyp2c11
vitamin A deficiency pathwayAldh1a1 , Aldh1a2 , Awat1 , Bco1 , Cyp26a1 , Cyp2a3 , Cyp2b3 , Cyp3a9 , Dgat1 , Dhrs3 , Dhrs4 , Dhrs9 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Lrat , Pdia2 , Pdia4 , Pdia6 , Ppib , Rdh11 , Rdh12 , Rdh16 , Rdh8 , Retsat , RGD1562200 , Rpe65 , Sdf2l1 , Ugt1a1
Phenotype Annotations Associated with Genes in the retinol metabolic pathway

References Associated with the retinol metabolic pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: