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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:34682
Term: diazinon
Definition: A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.
Chemical ID: MESH:D003976
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2affects metabolic processingISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein affects the metabolism of DiazinonPMID:15764407
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDDiazinon results in increased expression of CYP3A4 mRNAPMID:16757081 PMID:35331105
Cyp3a2increases methylationISOCYP3A4 (Homo sapiens)6480464CTDDiazinon results in increased methylation of CYP3A4 promoterPMID:35331105
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in decreased sulfation of and results in increased activity of Diazinon; CYP3A4 protein results in increased metabolism of and results in increased activity of DiazinonPMID:11708902 PMID:15764407
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