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PARACETAMOL PHARMACOKINETICS PATHWAY (PW:0001525)

View Ontology Report

Description

Paracetamol or N-acetyl-p-aminophenol (APAP), also known as acetaminophen or by its trade in the USA as Tylenol, is a widely used analgesic and antipyretic drug. However, overdose of paracetamol - accidental or intentional - is associated with hepatotoxicity and a leading cause of liver failure. APAP metabolism occurs in the liver where it is primarily subject to glucuronidation and sulfation by members of phase II biotransformation enzymes. To a lesser extent, it is also metabolized by members

Pathway Diagram:

Elsevier Inc. paracetamol sulfate ---> biliary excretion paracetamol glucuronide ---> biliary excretion Abcc2 APAP-GSH ---> biliary excretion paracetamol sulfate ---> basolateral excretion paracetamol glucuronide ---> basolateral excretion glutathione Abcc4 Abcc3 Abcg2 paracetamol ---> paracetamol glucuronide paracetamol ---> paracetamol sulfate Napqi ---> APAP-GSH biliary excretion basolateral excretion glutathione ---- Napqi paracetamol ---> Napqi Cyp2e1 paracetamol sulfate paracetamol paracetamol glucuronide APAP-GSH Napqi UGT1A1 UGT1A6 SULT1A1 SULT1A3 SULT1A4 SULT1E1
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Genes in Pathway:


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paracetamol pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB SMP:00640 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00640 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 TAS RGD PMID:23462933 RGD:8552693 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 TAS RGD PMID:23462933 RGD:8552693 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 TAS
ISO
SMPDB
RGD
PMID:23462933 SMP:00640, RGD:8552693 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00640 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 TAS
ISO
SMPDB
RGD
PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 ISO SMPDB SMP:00640 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO SMPDB SMP:00640 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO SMPDB
RGD
PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO SMPDB SMP:00640 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00640 NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00640 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO SMPDB SMP:00640 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO SMPDB SMP:00640 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00640 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00640 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO SMPDB SMP:00640 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186
JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 ISO SMPDB SMP:00640 NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 ISO SMPDB SMP:00640 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 ISO SMPDB SMP:00640 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613
JBrowse link
G Ppib peptidylprolyl isomerase B ISO SMPDB SMP:00640 NCBI chr 8:66,603,877...66,609,734
Ensembl chr 8:66,603,861...66,630,428
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 ISO SMPDB SMP:00640 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 ISO SMPDB SMP:00640 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 ISO SMPDB
RGD
PMID:23462933 SMP:00640, RGD:8552693 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 ISO SMPDB SMP:00640 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 ISO SMPDB
RGD
PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 ISO SMPDB
RGD
PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 ISO SMPDB SMP:00640 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link

Pathway Gene Annotations

Disease Annotations Associated with Genes in the paracetamol pharmacokinetics pathway
Disease TermsGene Symbols
3-Methylcrotonyl-CoA carboxylase 1 deficiencyAbcc5
3MC syndrome 1Dnajb11
acoustic neuromaCyp2e1
acquired immunodeficiency syndromeAbcb1a
acute chest syndromeGstt1
Acute Coronary SyndromeGstp1
Acute Experimental PancreatitisHspa5
acute kidney failureCyp1a2 , Cyp2d4 , Cyp2e1 , Gstp1 , Ugt1a1 , Ugt1a9
Acute Liver FailureAbcc2 , Ugt1a1
Acute Lung InjuryHspa5
acute lymphoblastic leukemiaAbcb1a , Abcc2 , Abcg2 , Cyp1a2 , Cyp2d4 , Cyp2e1 , Gstp1 , Gstt1
acute megakaryocytic leukemiaAbcg2
acute myeloid leukemiaAbcc3 , Abcg2 , Cyp2d4 , Gstp1 , Gstt1
acute promyelocytic leukemiaGstt1
adenocarcinomaCyp2e1
adenomaAbcg2
adrenocortical carcinomaAbcb1a
aggressive periodontitisGstt1
Aicardi-Goutieres Syndrome 3Gstp1
Airway ObstructionGstp1
alcohol dependenceCyp2d4 , Gstt1
alcohol use disorderCyp2e1
Alcoholic Fatty LiverCyp2e1
alcoholic hepatitisSult1e1
alcoholic liver cirrhosisCyp2e1
Alcoholic Liver DiseasesCyp2e1 , Gstt1
allergic diseaseGstp1
allergic rhinitisAbcb1a
alopeciaAbcc2
Alzheimer's diseaseAbcb1a , Abcc1 , Cyp2d4 , Gstp1 , Gstt1
amenorrheaCyp2e1
amphetamine abuseCyp2d4 , Gstp1 , Gstt1
amyotrophic lateral sclerosisGstp1
Anal Atresia, Hypospadias, and Penoscrotal InversionAbcc4
anemiaGstt1
Anthracycline-induced CardiotoxicityAbcb1a
antisocial personality disorderAbcb1a
anxiety disorderCyp3a2
aplastic anemiaGstt1
asbestosisCyp2e1 , Gstt1 , Hspa5
AsthenozoospermiaGstt1
asthmaAbcb1a , Abcc1 , Cyp2d4 , Cyp2e1 , Gstp1 , Gstt1
atopic dermatitisGstp1 , Gstt1
AtrophyCyp1a2
autism spectrum disorderAbcb1a , Abcc3 , Abcg2 , Cyp1a2 , Cyp2d4 , Gstp1 , Ugt1a1 , Ugt1a6
autistic disorderAbcc1 , Gstp1
autoimmune hepatitisCyp2d4
autosomal dominant nonsyndromic deafness 77Abcc1
autosomal dominant polycystic kidney diseaseAbcg2
B-Cell Chronic Lymphocytic LeukemiaAbcg2
B-cell lymphomaAbcg2
bacterial pneumoniaAbcc1
Bardet-Biedl syndromeCyp1a2
basal ganglia diseaseCyp2d4
Behcet's diseaseAbcb1a
benign neoplasmSult1a1
beta thalassemiaGstt1
bicuspid aortic valve diseasePdia2
bilirubin metabolic disorderAbcc2 , Abcc3 , Ugt1a1 , Ugt1a6 , Ugt1a9
Binge DrinkingCyp2e1
Bloom syndromeCyp1a2 , Ppib
bone marrow diseaseGstp1
BradycardiaCyp2d4
breast cancerCyp1a2 , Cyp3a2 , Gstp1 , Gstt1 , Sult1a1 , Sult1e1 , Ugt1a1
Breast Cancer, FamilialAbcc1
breast carcinomaAbcg2
Breast NeoplasmsAbcb1a , Abcc1 , Abcg2 , Cyp2d4 , Cyp3a2 , Gstp1 , Hspa5 , Sult1a1
bronchiolo-alveolar adenocarcinomaGstp1
bronchopulmonary dysplasiaGstp1 , Gstt1
bronchus carcinomaGstp1
cancerGstt1
cannabis abuseAbcb1a
cannabis dependenceAbcb1a
carcinomaAbcb1a , Gstp1 , Gstt1
CardiomegalyCyp2e1
cardiomyopathyAbcb1a , Abcc2 , Abcg2
cardiovascular system diseaseGstt1
carotid artery diseaseGstp1
cataractGstt1
CD3epsilon deficiencyHyou1
cervical cancerGstt1
cervix carcinomaGstt1
Chemical and Drug Induced Liver InjuryAbcb1a , Abcc1 , Abcc2 , Cyp1a2 , Cyp2d4 , Cyp2e1 , Cyp3a2 , Gstp1 , Gstt1 , Hspa5 , Sult1e1 , Ugt1a1 , Ugt1a9
Chemotherapy-Induced Febrile NeutropeniaGstp1
cholangiocarcinomaAbcc2 , Gstp1 , Ugt1a9
CholangiofibrosisGstp1
cholecystolithiasisUgt1a1
cholelithiasisUgt1a1
cholestasisAbcc2 , Abcc3 , Abcc4 , Cyp1a2 , Cyp3a2 , Gstp1 , Ugt1a1
Chromosome 11, Partial Trisomy 11qHyou1
chromosome 16p11.2 deletion syndrome, 220-kbSult1a1
chromosome 22q11.2 deletion syndrome, distalSdf2l1
Chromosome AberrationsGstp1 , Gstt1 , Sult1a1
Chronic BronchitisCyp2e1 , Gstt1
Chronic Cerebral HypoperfusionGstp1
Chronic Hepatitis CAbcb1a , Cyp2d4 , Gstt1
Chronic Intermittent HypoxiaHspa5
chronic myeloid leukemiaAbcb1a , Abcc2 , Abcg2 , Gstp1 , Hspa5
chronic obstructive pulmonary diseaseAbcc1 , Cyp1a2 , Cyp2e1 , Gstp1 , Gstt1
clear cell renal cell carcinomaGstp1
cognitive disorderAbcc4 , Cyp2d4
colon cancerCyp2e1
Colonic NeoplasmsSult1a1
colorectal adenocarcinomaAbcb1a , Gstt1
colorectal adenomaGstp1
colorectal cancerCyp1a2 , Cyp2e1 , Gstt1 , Ppib
colorectal carcinomaGstt1
Colorectal NeoplasmsAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcc4 , Abcc5 , Abcg2 , Cyp1a2 , Gstp1 , Sult1a1
ComaCyp2d4
common variable immunodeficiency 4Cyp2d4
Congenital AbnormalitiesGstt1
congenital disorder of glycosylation IdAbcc5
congenital heart diseaseAbcb1a , Gstp1 , Gstt1
congestive heart failureAbcg2 , Cyp1a2
conjunctivochalasisGstp1
contact dermatitisGstp1 , Ugt1a1 , Ugt1a6
Contrast-Induced NephropathyHspa5
coronary artery diseaseGstt1
CoughGstp1
COVID-19Abcb1a , Gstt1 , Sult1a1
Crigler Najjar Syndrome, Type 2Ugt1a1 , Ugt1a6 , Ugt1a9
Crigler-Najjar syndromeUgt1a1 , Ugt1a6 , Ugt1a9
Critical IllnessAbcb1a
Crohn's diseaseAbcb1a , Gstt1 , Sdf2l1 , Ugt1a1
cryoglobulinemiaAbcb1a
Currarino syndromeAbcc5
cystic fibrosisGstp1 , Gstt1
cystic kidney diseaseDnajb11
depressive disorderCyp1a2 , Cyp2e1
Desbuquois Dysplasia 1Abcc1
Developmental Delay with Variable Intellectual Impairment and Behavioral AbnormalitiesCyp2d4
Diabetes ComplicationsAbcc4
diabetes mellitusAbcg2 , Gstt1
Diabetic CardiomyopathiesHsp90b1 , Hspa5
Diabetic NephropathiesGstt1 , Hspa5
diabetic retinopathyGstt1
diarrheaAbcb1a , Abcc2 , Abcg2
diffuse large B-cell lymphomaAbcb1a , Abcg2 , Gstp1 , Gstt1
DiGeorge syndromeSdf2l1
disease of cellular proliferationAbcb1a , Gstt1
disease of mental healthAbcb1a
Disease ProgressionAbcb1a , Abcc1 , Gstp1
Disease SusceptibilityGstt1
distal 10q deletion syndromeCyp2e1
dopamine beta-hydroxylase deficiencyHspa5
drug allergyAbcc2 , Gstp1 , Gstt1
drug dependenceAbcb1a
Drug EruptionsCyp2e1
Drug OverdoseAbcb1a , Cyp2d4
Drug-induced AnemiaGstt1
Drug-Induced DyskinesiaCyp2d4
drug-induced hepatitisAbcc2 , Cyp2e1
Drug-Induced Immune ThrombocytopeniaAbcc2 , Gstt1
Drug-Induced LeukopeniaGstp1 , Gstt1
Drug-induced NeutropeniaAbcb1a , Abcc2 , Gstp1 , Gstt1 , Ugt1a1
Drug-Related Side Effects and Adverse ReactionsAbcb1a , Abcc1 , Abcc2 , Abcc4 , Abcg2 , Cyp1a2 , Cyp2d4 , Cyp2e1 , Ugt1a1
Dubin-Johnson syndromeAbcc2 , Abcc3
DwarfismHyou1
DysmenorrheaCyp2d4
dystoniaCyp2d4
encephalitisAbcb1a
end stage renal diseaseAbcb1a , Abcc2 , Abcc3 , Cyp3a2 , Gstt1
endometrial cancerCyp1a2 , Sult1a1 , Sult1e1 , Ugt1a1
Endometrial NeoplasmsSult1a1
endometriosisAbcc4
EndotoxemiaAbcb1a , Abcc2
EosinophiliaAbcb1a
epilepsyAbcb1a , Abcc1 , Gstt1 , Pdia2
epilepsy with generalized tonic-clonic seizuresCyp2d4
EpistaxisGstt1
erythropoietic protoporphyriaAbcg2
Escherichia Coli InfectionsAbcb1a
esophageal cancerGstt1
Esophageal NeoplasmsAbcb1a , Gstt1
esophagus adenocarcinomaGstt1
esophagus squamous cell carcinomaAbcc2 , Gstp1 , Gstt1 , Hspa5 , Sult1a1
essential tremorGstp1
exfoliation syndromeGstt1
Experimental ArthritisAbcb1a , Abcg2
Experimental Autoimmune MyocarditisHspa5
Experimental Diabetes MellitusAbcb1a , Abcc2 , Abcc3 , Abcg2 , Cyp2e1
Experimental Liver CirrhosisAbcb1a , Abcc2 , Abcc5 , Cyp1a2 , Cyp2d4 , Sult1e1 , Sult2a1
Experimental Liver NeoplasmsCyp1a2 , Cyp2e1 , Gstp1
Experimental Mammary NeoplasmsAbcb1a , Abcg2
Experimental SeizuresGstp1
extrahepatic cholestasisAbcc4
extrapyramidal and movement diseaseCyp2d4
extrinsic allergic alveolitisCyp2e1
familial adenomatous polyposisAbcb1a
familial hyperlipidemiaAbcb1a , Cyp2e1
familial mediterranean feverAbcb1a , Cyp3a2
Familial Prostate CancerCyp3a2
familial temporal lobe epilepsy 3Abcb1a
Fanconi anemiaGstt1
Female InfertilityHspa5
Femur Head NecrosisAbcb1a , Gstt1
Fetal Growth RetardationAbcb1a , Gstt1
FeverGstt1
Focal Nodular HyperplasiaGstp1
Gallbladder NeoplasmsGstp1
GallstonesUgt1a1
gastrointestinal system diseaseAbcc2
genetic diseaseAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcc4 , Abcc5 , Abcg2 , Cyp1a2 , Cyp2d4 , Cyp2e1 , Cyp3a2 , Dnajb11 , Erp29 , Gstp1 , Gstt1 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Sult1a1 , Sult1e1 , Sult2a1 , Ugt1a1 , Ugt1a6 , Ugt1a9
Genetic Predisposition to DiseaseAbcb1a
Genetic TranslocationAbcb1a
Genomic InstabilitySult1a1
Germ Cell and Embryonal NeoplasmsAbcb1a
Gilbert syndromeUgt1a1 , Ugt1a6 , Ugt1a9
glioblastomaGstt1
glycogen storage disease IbHyou1
goutAbcg2
Gram-Negative Bacterial InfectionsUgt1a1
Graves' diseaseGstp1
Growth DisordersCyp1a2
head and neck cancerGstt1
head and neck squamous cell carcinomaAbcb1a , Abcc1 , Abcc2 , Abcg2 , Cyp2d4
Hearing Loss, Noise-InducedGstt1
heart diseaseAbcb1a , Abcc1 , Abcc2
Helicobacter InfectionsAbcb1a
Hematologic NeoplasmsAbcb1a , Gstt1 , Hspa5
hematopoietic system diseaseGstp1 , Ugt1a1
hepatitis BUgt1a1 , Ugt1a6
hepatitis CCyp3a2
hepatocellular adenomaCyp2e1
hepatocellular carcinomaAbcb1a , Abcc3 , Cyp1a2 , Cyp2e1 , Erp29 , Gstp1 , Gstt1 , Hspa5
HepatomegalyAbcc3 , Cyp1a2
hereditary breast ovarian cancer syndromeAbcb1a , Abcg2
Hereditary HyperbilirubinemiaUgt1a1
heroin dependenceAbcb1a
high grade gliomaCyp2e1 , Gstp1 , Hspa5
Hirschsprung's diseaseGstt1
Hodgkin's lymphomaGstp1 , Gstt1 , Ugt1a1
holoprosencephaly 5Abcc4
human immunodeficiency virus infectious diseaseAbcb1a , Ppib
Human Viral HepatitisCyp2e1
Hyperbilirubinemia, Transient Familial NeonatalUgt1a1 , Ugt1a6 , Ugt1a9
hyperprolactinemiaAbcc3
hypertensionAbcc1 , Gstp1 , Gstt1
hyperthyroidismUgt1a1
hypertrophic cardiomyopathyCyp2e1
hyperuricemiaAbcg2
hypospadiasGstt1
HypotensionSult1a1
idiopathic generalized epilepsyAbcb1a , Pdia2
immunodeficiency 17Hyou1
immunodeficiency 18Hyou1
immunodeficiency 19Hyou1
immunodeficiency 59Hyou1
infectious mononucleosisGstt1
InflammationAbcb1a , Cyp3a2 , Ugt1a1
inflammatory bowel diseaseGstt1 , Hspa5
inflammatory bowel disease 13Abcb1a
inflammatory bowel disease 28Hyou1
intellectual disabilityCyp2d4 , Gstp1
interstitial nephritisCyp2d4
Intestinal Reperfusion InjuryCyp1a2
intestinal volvulusAbcc1
intrahepatic cholestasisCyp2e1
invasive ductal carcinomaAbcb1a
Iron OverloadGstt1
isolated microphthalmia 5Hyou1
JaundiceCyp1a2 , Ugt1a1
Joubert syndrome 22Ugt1a1 , Ugt1a6 , Ugt1a9
juvenile rheumatoid arthritisGstt1
kernicterusUgt1a1
Kidney CalculiGstp1
kidney diseaseAbcb1a , Abcc3 , Gstp1
Kidney NeoplasmsAbcb1a , Gstt1
Kidney Reperfusion InjuryGstt1
Kuhnt-Junius degenerationGstp1 , Gstt1
Laryngeal NeoplasmsGstp1
late onset Parkinson's diseaseGstp1
Latent TuberculosisAbcb1a
Leber congenital amaurosis 7Sult2a1
leukemiaGstt1
leukopeniaGstt1
LeukoplakiaGstt1
liver cirrhosisCyp1a2 , Gstt1
liver diseaseCyp1a2 , Cyp2e1 , Gstp1 , Gstt1 , Sult1e1
Liver InjuryAbcg2 , Cyp1a2 , Cyp2e1
Liver NeoplasmsCyp2e1
long QT syndrome 10Hyou1
lung adenocarcinomaErp29 , Hsp90b1 , Sult1a1
lung cancerAbcc1 , Gstt1 , Sult1a1
lung diseaseCyp2e1 , Gstp1 , Gstt1
Lung InjuryCyp1a2
Lung NeoplasmsCyp1a2 , Cyp2e1 , Gstp1 , Gstt1
lung non-small cell carcinomaAbcb1a , Abcc2 , Cyp2e1 , Gstp1 , Ugt1a1
lung squamous cell carcinomaSult1a1
lymphoid leukemiaGstp1 , Gstt1
Lynch syndromeGstt1
major depressive disorderCyp2d4
malariaAbcb1a
male infertility due to globozoospermiaHsp90b1
malignant astrocytomaGstp1
Manganese PoisoningCyp2d4
medulloblastomaGstt1
melanomaGstp1
meningitisGstp1
metabolic dysfunction-associated steatotic liver diseaseAbcb1a , Abcc2 , Abcc3 , Cyp1a2 , Cyp2e1 , Gstp1 , Gstt1
Metabolic Side Effects of Drugs and SubstancesCyp1a2
methemoglobinemiaCyp1a2
Micronuclei, Chromosome-DefectiveCyp2e1 , Gstt1
middle cerebral artery infarctionCyp2e1
mitochondrial metabolism diseaseGstp1
morbid obesityCyp2e1
motor neuron diseaseGstt1
Mouth AbnormalitiesGstt1
movement diseaseGstp1
mucositisGstt1
multiple myelomaAbcg2 , Cyp2d4 , Gstp1 , Gstt1
multiple sclerosisGstp1 , Gstt1
Muscle RigidityCyp2d4
myelodysplastic syndromeGstp1 , Gstt1
myeloid leukemiaGstp1 , Gstt1 , Ugt1a1
myeloid neoplasmHspa5
myocardial infarctionHspa5
Myocardial IschemiaGstp1 , Sult1a1
Myocardial Reperfusion InjuryHspa5
Nasal PolypsAbcb1a , Gstt1
nasal type extranodal NK/T-cell lymphomaAbcb1a
nasopharynx carcinomaCyp2e1
NauseaAbcb1a
NecrosisCyp2e1 , Gstp1
nemaline myopathy 6Ppib
Neonatal HyperbilirubinemiaUgt1a1
Neoplasm InvasivenessCyp2e1
Neoplasm MetastasisAbcb1a , Abcc4 , Erp29 , Sult1e1
nephroblastomaAbcb1a
Nerve DegenerationHspa5
nervous system diseaseAbcb1a , Abcc2 , Abcg2
neural tube defectCyp1a2 , Sult1a1
neuroblastomaAbcb1a
neuronal ceroid lipofuscinosisHspa5 , Sult1a1
neutropeniaAbcb1a , Gstt1 , Ugt1a1
non-Hodgkin lymphomaCyp2e1
obesityCyp2e1 , Gstt1 , Hspa5
obstructive sleep apneaAbcb1a
Occupational DiseasesCyp2d4
oligohydramniosDnajb11
opiate dependenceAbcb1a , Cyp2d4
optic neuritisGstt1
oral cavity cancerCyp2e1 , Gstt1
oral mucosa leukoplakiaGstt1
oral squamous cell carcinomaCyp2e1 , Gstp1
oral submucous fibrosisGstt1
orofacial cleftGstt1
Orthostatic HypotensionAbcb1a
osteogenesis imperfectaPpib
osteogenesis imperfecta type 9Ppib
osteoporosisGstp1
osteosarcomaCyp3a2 , Gstp1
ovarian cancerAbcb1a , Gstp1 , Ugt1a1
ovarian carcinomaCyp3a2 , Gstt1
Ovarian NeoplasmsAbcb1a , Abcg2 , Sult1a1
ovary epithelial cancerGstt1
PainAbcb1a
pancreatic adenocarcinomaGstt1
pancreatic cancerAbcc2 , Abcc3 , Abcc5 , Gstp1
pancreatic ductal carcinomaGstp1
Parkinson's diseaseAbcb1a , Cyp2d4 , Cyp2e1 , Gstp1 , Gstt1
Patent Ductus VenosusCyp2e1
Perennial Allergic RhinitisGstp1
Perinatal AsphyxiaGstt1
perinatal necrotizing enterocolitisAbcb1a
Peripheral Nerve InjuriesHspa5
peripheral nervous system diseaseAbcb1a , Abcc1 , Gstp1 , Gstt1
peritonitisGstp1
Perlman syndromeUgt1a1 , Ugt1a6 , Ugt1a9
Phenacetin O-Deethylase, Deficiency ofCyp1a2
Plasmodium falciparum malariaGstp1
pleomorphic xanthoastrocytomaAbcb1a , Cyp3a2
pneumoniaCyp2e1
PoisoningAbcb1a
Polycystic Kidney Disease 6 with or without Polycystic Liver DiseaseDnajb11
PolyuriaUgt1a1
Poor Drug Metabolism, CYP2D6-RelatedCyp2d4
porphyria cutanea tardaCyp1a2
post-traumatic stress disorderHspa5
Postoperative PainAbcb1a
pre-eclampsiaGstp1
pre-malignant neoplasmGstp1 , Gstt1
Premature BirthGstt1
Prenatal Exposure Delayed EffectsCyp2d4
PresbycusisGstt1
primary biliary cholangitisAbcc2 , Abcg2
primary open angle glaucomaGstt1
prostate cancerAbcc4 , Gstp1 , Gstt1 , Sult1a1 , Sult2a1
prostate carcinoma in situGstp1
prostatic hypertrophyGstp1
Prostatic NeoplasmsAbcc4 , Cyp2d4 , Cyp2e1 , Cyp3a2 , Erp29 , Gstp1 , Gstt1 , Hsp90b1 , Sdf2l1 , Sult1a1 , Sult1e1 , Sult2a1
Pseudomonas InfectionsGstp1
pseudoxanthoma elasticumAbcc1 , Abcc2
psoriasisGstp1
pulmonary emphysemaGstp1
pulmonary fibrosisGstp1 , Hspa5
pulmonary tuberculosisAbcb1a , Gstt1
RASopathyHyou1
Raynaud diseaseGstt1
RecurrenceSult1a1
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsGstp1
renal cell carcinomaAbcb1a , Abcg2 , Gstp1 , Gstt1
Reperfusion InjuryAbcb1a , Abcc5 , Abcg2 , Cyp2e1 , Gstp1 , Hspa5 , Sult1e1
respiratory allergyHspa5
Respiratory SoundsGstp1
respiratory system diseaseGstp1
rheumatoid arthritisAbcb1a , Abcc2 , Abcc3 , Abcc4 , Abcc5 , Abcg2 , Gstt1 , Hspa5
rhinitisCyp2d4
sarcomaGstp1
schizophreniaAbcc1 , Cyp1a2 , Hyou1 , Sult1a1
secondary hyperparathyroidismAbcg2
secondary Parkinson diseaseAbcb1a
senile cataractGstp1 , Gstt1
SepsisCyp1a2 , Cyp2e1
sexual health disorderCyp2d4
short-rib thoracic dysplasia 9 with or without polydactylyPdia2
sickle cell anemiaGstt1
skin melanomaGstt1
Skin NeoplasmsGstt1
small cell carcinomaUgt1a1
Spinal Cord InjuriesHspa5
Spinal Cord Reperfusion InjuryHspa5
spinocerebellar ataxia type 17Hspa5 , Hyou1
splenic diseaseCyp1a2
SplenomegalyCyp1a2
Spontaneous AbortionsSdf2l1
squamous cell carcinomaCyp1a2 , Gstp1
ST Elevation Myocardial InfarctionAbcb1a
StarvationUgt1a1
status epilepticusAbcb1a , Abcc2 , Abcg2
steatotic liver diseaseAbcc2 , Abcc3 , Cyp2e1 , Hspa5
stomach cancerCyp2e1 , Gstt1 , Sult1a1
Stomach NeoplasmsGstp1
Subarachnoid HemorrhageCyp3a2
substance-induced psychosisGstp1
substance-related disorderAbcc4 , Cyp2d4
T-cell acute lymphoblastic leukemiaAbcg2
Tardive DyskinesiaCyp1a2
temporal lobe epilepsyAbcb1a
Temporomandibular Joint OsteoarthritisHspa5
testicular cancerGstp1
Testicular InjuryCyp2e1
Therapy-related Acute Myeloid LeukemiaGstt1
Torsades de PointesCyp3a2
toxic encephalopathyAbcb1a , Abcg2 , Gstp1
transient cerebral ischemiaHspa5
transitional cell carcinomaGstt1
Transplant RejectionGstt1
traumatic brain injuryCyp2d4
TremorCyp2d4
trichodontoosseous syndromeAbcc3
type 1 diabetes mellitusCyp2e1 , Gstt1 , Ugt1a1
type 2 diabetes mellitusAbcb1a , Abcc2 , Abcg2 , Cyp1a2 , Cyp2e1 , Cyp3a2 , Gstp1 , Gstt1 , Sdf2l1 , Ugt1a1 , Ugt1a6
ulcerative colitisAbcb1a , Gstt1
Ureteral CalculiGstp1
ureteral obstructionHspa5
urinary bladder cancerGstp1 , Gstt1 , Sult1a1
Urologic NeoplasmsSult1a1
Vaso-occlusive CrisisGstt1
venous insufficiencyGstt1
vestibular diseaseGstp1
visual epilepsyAbcb1a , Abcc2 , Hspa5
VITAMIN D-DEPENDENT RICKETS, TYPE 3Cyp3a2
Vitamin E DeficiencyCyp1a2
Volvulus Of MidgutAbcc1
VomitingAbcb1a
Weight GainCyp2d4
Zika feverHspa5
Pathway Annotations Associated with Genes in the paracetamol pharmacokinetics pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayCyp2e1
antigen processing and presentation pathwayHspa5
antipyrine drug pathwayCyp2e1
arachidonic acid metabolic pathwayCyp2e1
artemether pharmacokinetics pathwayCyp3a2 , Ugt1a9
ascorbate and aldarate metabolic pathwayUgt1a1 , Ugt1a6 , Ugt1a9
axitinib pharmacokinetics pathwayAbcb1a , Cyp1a2 , Cyp3a2 , Ugt1a1
azathioprine pharmacodynamics pathwayAbcc4 , Abcc5
bile acid signaling pathwayAbcc2 , Abcc4
bile acid transport pathwayAbcb1a , Abcc2 , Abcc3 , Abcc4 , Abcg2 , Sult2a1
caffeine metabolic pathwayCyp1a2
caffeine pharmacokinetics pathwayCyp1a2 , Cyp2e1 , Cyp3a2
carbamazepine pharmacokinetics pathwayCyp3a2
celecoxib pharmacodynamics pathwayCyp2d4 , Cyp2e1 , Cyp3a2
celecoxib pharmacokinetics pathwayCyp2d4 , Cyp3a2
citalopram pharmacodynamics pathwayCyp2d4
citalopram pharmacokinetics pathwayCyp2d4
clomipramine pharmacokinetics pathwayCyp1a2 , Cyp2d4 , Cyp3a2
clopidogrel pharmacodynamics pathwayAbcb1a , Cyp1a2 , Cyp3a2
clopidogrel pharmacokinetics pathwayAbcb1a , Cyp1a2 , Cyp3a2
codeine and morphine pharmacodynamics pathwayCyp2d4 , Cyp3a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
codeine and morphine pharmacokinetics pathwayCyp2d4 , Cyp3a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
cyclophosphamide pharmacodynamics pathwayCyp3a2
cyclophosphamide pharmacokinetics pathwayCyp3a2
desipramine pharmacodynamics pathwayCyp2d4
desipramine pharmacokinetics pathwayCyp2d4
diclofenac pharmacodynamics pathwayCyp2e1
diflunisal pharmacodynamics pathwayCyp2e1
disulfiram pharmacodynamics pathwayCyp2e1
docetaxel pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
doxepin pharmacokinetics pathwayCyp1a2 , Cyp2d4 , Cyp3a2
doxorubicin pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2
Endoplasmic Reticulum-associated degradation pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia4 , Pdia6
erlotinib pharmacodynamics pathwayAbcb1a , Abcg2
estradiol biosynthetic pathwaySult1e1 , Sult2a1
etodolac pharmacodynamics pathwayCyp2e1
etoposide pharmacodynamics pathwayAbcb1a , Abcc3 , Cyp3a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
etoposide pharmacokinetics pathwayAbcb1a , Abcc3 , Cyp3a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
felbamate pharmacokinetics pathwayCyp2e1 , Cyp3a2
fenoprofen pharmacodynamics pathwayCyp2e1
fluoxetine pharmacodynamics pathwayCyp2d4 , Cyp3a2
fluoxetine pharmacokinetics pathwayCyp2d4 , Cyp3a2
flurbiprofen pharmacodynamics pathwayCyp2e1
gefitinib pharmacokinetics pathwayAbcb1a , Abcg2 , Cyp2d4 , Cyp3a2
glutathione conjugation pathwayGstp1 , Gstt1
glutathione metabolic pathwayGstp1 , Gstt1
hypoxia inducible factor pathwayAbcb1a , Abcg2
ibuprofen pharmacodynamics pathwayCyp2e1 , Cyp3a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
ibuprofen pharmacokinetics pathwayCyp3a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
ifosfamide pharmacodynamics pathwayCyp3a2
ifosfamide pharmacokinetics pathwayCyp3a2
imipramine pharmacodynamics pathwayCyp1a2 , Cyp2d4 , Cyp3a2
imipramine pharmacokinetics pathwayCyp1a2 , Cyp2d4 , Cyp3a2
indometacin pharmacodynamics pathwayCyp2e1
indometacin pharmacodynamics pathwayCyp2e1
interleukin-6 signaling pathwayHsp90b1
irinotecan pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2 , Cyp3a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
irinotecan pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2 , Cyp3a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
ketoprofen pharmacodynamics pathwayCyp2e1
ketorolac pharmacodynamics pathwayCyp2e1
lamivudine pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcc4 , Abcg2 , Sult1a1
leukotriene C4 synthase deficiency pathwayCyp2e1
lidocaine pharmacodynamics pathwayCyp1a2 , Cyp3a2
lidocaine pharmacokinetics pathwayCyp1a2 , Cyp3a2
linoleic acid metabolic pathwayCyp1a2 , Cyp2e1 , Cyp3a2
lornoxicam pharmacodynamics pathwayCyp2e1
losartan pharmacokinetics pathwayAbcb1a , Cyp3a2 , Ugt1a1
magnesium salicylate pharmacodynamics pathwayCyp2e1
mefenamic acid pharmacodynamics pathwayCyp2e1
meloxicam pharmacodynamics pathwayCyp2e1
mercaptopurine pharmacodynamics pathwayAbcc4 , Abcc5
mercaptopurine pharmacokinetics pathwayAbcc4 , Abcc5
methadone pharmacodynamics pathwayCyp2d4 , Cyp3a2
methadone pharmacokinetics pathwayCyp2d4 , Cyp3a2
multidrug resistance-associated protein mediated transport pathwayAbcc1 , Abcc2 , Abcc3 , Abcc4 , Abcc5
mycophenolic acid pharmacokinetics pathwayAbcb1a , Abcc2 , Abcg2 , Cyp3a2 , Ugt1a9
nabumetone pharmacodynamics pathwayCyp2e1
naproxen pharmacodynamics pathwayCyp2e1
nateglinide pharmacokinetics pathwayCyp3a2
neviparine pharmacokinetics pathwayCyp2d4 , Cyp3a2
nicotine pharmacodynamics pathwayUgt1a9
nicotine pharmacokinetics pathwayUgt1a9
NOD-like receptor signaling pathwayHsp90b1
O-linked glycan biosynthetic pathwayUgt1a1 , Ugt1a6 , Ugt1a9
paracetamol drug pathwayCyp2e1
paracetamol pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcc4 , Abcc5 , Abcg2 , Cyp1a2 , Cyp2d4 , Cyp2e1 , Cyp3a2 , Dnajb11 , Erp29 , Gstp1 , Gstt1 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Sult1a1 , Sult1e1 , Sult2a1 , Ugt1a1 , Ugt1a6 , Ugt1a9
paracetamol response pathwayCyp2e1
pentose and glucuronate interconversion pathwayUgt1a1 , Ugt1a6 , Ugt1a9
phase I biotransformation pathway via cytochrome P450Cyp1a2 , Cyp2d4 , Cyp2e1 , Cyp3a2 , Gstp1 , Gstt1 , Ugt1a1 , Ugt1a6 , Ugt1a9
phenytoin pharmacodynamics pathwayCyp1a2 , Cyp2e1 , Cyp3a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a6 , Ugt1a9
piroxicam pharmacodynamics pathwayCyp2e1
porphyrin and chlorophyll metabolic pathwayUgt1a1 , Ugt1a6 , Ugt1a9
prednisone pharmacodynamics pathwayCyp3a2
prednisone pharmacokinetics pathwayCyp3a2
prion disease pathwayHspa5
prostate cancer pathwayGstp1 , Hsp90b1
repaglinide pharmacokinetics pathwayCyp3a2
retinol metabolic pathwayCyp1a2 , Cyp3a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a6 , Ugt1a9
salicylic acid pharmacodynamics pathwayCyp2e1
sodium salicylate pharmacodynamics pathwayCyp2e1
sorafenib pharmacokinetics pathwayCyp3a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
sphingosine 1-phosphate signaling pathwayAbcc1
starch and sucrose metabolic pathwayUgt1a1 , Ugt1a6 , Ugt1a9
statin pharmacokinetics pathwayAbcb1a , Abcc2 , Abcg2 , Cyp2d4 , Cyp3a2 , Ugt1a1
steroid hormone biosynthetic pathwayCyp3a2 , Sult1e1 , Ugt1a1 , Ugt1a6 , Ugt1a9
sulfite oxidase deficiency pathwaySult1a1 , Sult1e1
sulfur metabolic pathwaySult1a1 , Sult1e1
sulindac pharmacodynamics pathwayCyp2e1
syndecan signaling pathwayPpib
tamoxifen pharmacodynamics pathwayCyp2d4 , Cyp3a2 , Sult1a1
tamoxifen pharmacokinetics pathwayAbcb1a , Cyp1a2 , Cyp2d4 , Cyp3a2 , Sult1a1 , Sult2a1 , Ugt1a1 , Ugt1a9
teniposide pharmacodynamics pathwayCyp3a2
teniposide pharmacokinetics pathwayCyp3a2
tenoxicam pharmacodynamics pathwayCyp2e1
testosterone biosynthetic pathwaySult2a1
tiaprofenic acid pharmacodynamics pathwayCyp2e1
tioguanine pharmacodynamics pathwayAbcc4 , Abcc5
tolmetin pharmacodynamics pathwayCyp2e1
tramadol pharmacokinetics pathwayAbcc2 , Cyp2d4 , Cyp3a2
tryptophan metabolic pathwayCyp1a2
tyrosinemia type III pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
valdecoxib pharmacodynamics pathwayCyp2e1
venlafaxine pharmacokinetics pathwayAbcb1a , Cyp2d4 , Cyp3a2
vinblastine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Cyp3a2
vincristine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3
vindesine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3
vinorelbine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Cyp3a2
vitamin A deficiency pathwayCyp3a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
warfarin pharmacokinetics pathwayCyp1a2 , Cyp3a2 , Ugt1a1 , Ugt1a9
Phenotype Annotations Associated with Genes in the paracetamol pharmacokinetics pathway

References Associated with the paracetamol pharmacokinetics pathway:

Ontology Path Diagram:

paths to the root
paths to the root

Import into Pathway Studio: