PARACETAMOL PHARMACOKINETICS PATHWAY (PW:0001525)

View Ontology Report

Description

Paracetamol or N-acetyl-p-aminophenol (APAP), also known as acetaminophen or by its trade in the USA as Tylenol, is a widely used analgesic and antipyretic drug. However, overdose of paracetamol - accidental or intentional - is associated with hepatotoxicity and a leading cause of liver failure. APAP metabolism occurs in the liver where it is primarily subject to glucuronidation and sulfation by members of phase II biotransformation enzymes. To a lesser extent, it is also metabolized by members

Pathway Diagram:

Elsevier Inc. paracetamol sulfate ---> biliary excretion paracetamol glucuronide ---> biliary excretion Abcc2 APAP-GSH ---> biliary excretion paracetamol sulfate ---> basolateral excretion paracetamol glucuronide ---> basolateral excretion glutathione Abcc4 Abcc3 Abcg2 paracetamol ---> paracetamol glucuronide paracetamol ---> paracetamol sulfate Napqi ---> APAP-GSH biliary excretion basolateral excretion glutathione ---- Napqi paracetamol ---> Napqi Cyp2e1 paracetamol sulfate paracetamol paracetamol glucuronide APAP-GSH Napqi UGT1A1 UGT1A6 SULT1A1 SULT1A3 SULT1A4 SULT1E1
GO TO:

Genes in Pathway:

  • Rat
  • Mouse
  • Human
  • All
  • show annotations for term's descendants
  •     Sort by:
  • view all columns
paracetamol pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:10402751
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:10402751
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:8552693
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:8552693
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:8552693
RGD:10402751
G Abcc5 ATP binding cassette subfamily C member 5 JBrowse link 11 84,395,982 84,490,215 RGD:10402751
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 JBrowse link 4 88,765,441 88,890,268 RGD:8552693
RGD:10402751
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:10402751
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:10402751
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:8552693
RGD:10402751
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 JBrowse link 11 81,741,342 81,757,806 RGD:10402751
G Erp29 endoplasmic reticulum protein 29 JBrowse link 12 40,619,377 40,625,884 RGD:10402751
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:10402751
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:10402751
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link 7 27,226,570 27,240,533 RGD:10402751
G Hspa5 heat shock protein family A member 5 JBrowse link 3 13,838,304 13,842,763 RGD:10402751
G Hyou1 hypoxia up-regulated 1 JBrowse link 8 48,699,796 48,711,912 RGD:10402751
G Pdia2 protein disulfide isomerase family A, member 2 RGD:10402751
G Pdia4 protein disulfide isomerase family A, member 4 JBrowse link 4 77,470,636 77,489,535 RGD:10402751
G Pdia6 protein disulfide isomerase family A, member 6 JBrowse link 6 42,568,269 42,585,654 RGD:10402751
G Ppib peptidylprolyl isomerase B JBrowse link 8 71,719,681 71,725,538 RGD:10402751
G Sdf2l1 stromal cell-derived factor 2-like 1 JBrowse link 11 88,122,271 88,124,513 RGD:10402751
G Sult1a1 sulfotransferase family 1A member 1 JBrowse link 1 198,100,586 198,104,106 RGD:10402751
G Sult1e1 sulfotransferase family 1E member 1 JBrowse link 14 22,070,861 22,089,264 RGD:8552693
RGD:10402751
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:10402751
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:8552693
RGD:10402751
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:8552693
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:10402751

Pathway Gene Annotations

Disease Annotations Associated with Genes in the paracetamol pharmacokinetics pathway
Disease TermsGene Symbols
Abortion, SpontaneousSdf2l1
Acute Chest SyndromeGstt1
Acute Coronary SyndromeGstp1
Acute Kidney InjuryCyp1a2 , Cyp2d4 , Gstp1 , Ugt1a1 , Ugt1a9
AdenocarcinomaCyp2e1
Adenocarcinoma of EsophagusGstt1
Adenocarcinoma of LungErp29
Adenocarcinoma, Bronchiolo-AlveolarGstp1
AdenomaAbcg2
Adenoma, ColorectalGstp1
Adrenocortical CarcinomaAbcb1a
Airway ObstructionGstp1
AlcoholismCyp2e1
AlopeciaAbcc2
Alveolitis, Extrinsic AllergicCyp2e1
Alzheimer DiseaseCyp2d4 , Gstp1 , Gstt1
Amphetamine-Related DisordersCyp2d4 , Gstp1 , Gstt1
Amyotrophic Lateral SclerosisGstp1
AnemiaGstt1
Anemia, AplasticGstt1
Anemia, Sickle CellGstt1
Anthracycline-induced CardiotoxicityAbcb1a
Arthritis, ExperimentalAbcb1a , Abcg2
Arthritis, JuvenileGstt1
Arthritis, RheumatoidAbcb1a , Abcc2 , Abcc3 , Abcc4 , Abcc5 , Abcg2 , Gstt1 , Hspa5
AsbestosisCyp2e1 , Gstt1 , Hspa5
Asphyxia NeonatorumGstt1
AsthenozoospermiaGstt1
AsthmaAbcb1a , Abcc1 , Cyp2e1 , Gstp1 , Gstt1
AstrocytomaGstp1
AtrophyCyp1a2
Autistic DisorderGstp1
Basal Ganglia DiseasesCyp2d4
Behcet SyndromeAbcb1a
Beta-ThalassemiaGstt1
Bone Marrow DiseasesGstp1
BradycardiaCyp2d4
Breast Cancer, FamilialAbcc1
Breast NeoplasmsAbcb1a , Abcc1 , Abcg2 , Cyp1a2 , Cyp2d4 , Gstp1 , Gstt1 , Hspa5 , Sult1a1 , Sult1e1 , Ugt1a1
Bronchitis, ChronicCyp2e1 , Gstt1
Bronchopulmonary DysplasiaGstp1 , Gstt1
CarcinomaAbcb1a , Gstp1 , Gstt1
Carcinoma, BronchogenicGstp1
Carcinoma, Ductal, BreastAbcb1a
Carcinoma, HepatocellularAbcb1a , Abcc3 , Cyp2e1 , Erp29 , Gstp1 , Hspa5
Carcinoma, Non-Small-Cell LungAbcb1a , Abcc2 , Cyp2e1 , Gstp1 , Ugt1a1
Carcinoma, Pancreatic DuctalGstp1
Carcinoma, Renal CellAbcb1a , Abcg2 , Gstp1 , Gstt1
Carcinoma, Small CellUgt1a1
Carcinoma, Squamous CellCyp1a2 , Gstp1
Carcinoma, Squamous Cell of Head and NeckAbcb1a , Abcc1 , Abcc2 , Abcg2
Carcinoma, Transitional CellGstt1
CardiomegalyCyp2e1
Cardiovascular DiseasesGstt1
Carotid Artery DiseasesGstp1
CataractGstt1
Chemotherapy-Induced Febrile NeutropeniaGstp1
CholangiocarcinomaAbcc2 , Gstp1 , Ugt1a9
CholangiofibrosisGstp1
CholecystolithiasisUgt1a1
CholelithiasisUgt1a1
CholestasisAbcc2 , Abcc3 , Abcc4 , Gstp1
Chromosome AberrationsGstp1 , Gstt1 , Sult1a1
Chronic Cerebral HypoperfusionGstp1
Clear-Cell Metastatic Renal Cell CarcinomaGstp1
Cognition DisordersCyp2d4
Colitis, UlcerativeAbcb1a
Colonic NeoplasmsSult1a1
Colorectal NeoplasmsAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcc4 , Abcc5 , Abcg2 , Cyp1a2 , Sult1a1
Colorectal Neoplasms, Hereditary NonpolyposisGstt1
ComaCyp2d4
Congenital AbnormalitiesGstt1
ConjunctivochalasisGstp1
Coronary Artery DiseaseGstt1
CoughGstp1
Crigler Najjar Syndrome, Type 2Ugt1a1 , Ugt1a9
Crigler-Najjar SyndromeUgt1a1 , Ugt1a9
Crohn DiseaseAbcb1a , Gstt1 , Ugt1a1
Currarino TriadAbcc5
Cystic FibrosisGstp1 , Gstt1
Depressive DisorderCyp1a2 , Cyp2e1
Dermatitis, AtopicGstp1 , Gstt1
Dermatitis, ContactGstp1 , Ugt1a1
Diabetes MellitusGstt1
Diabetes Mellitus, ExperimentalAbcb1a , Abcc2 , Abcc3 , Abcg2 , Cyp2e1
Diabetes Mellitus, Type 1Cyp2e1 , Gstt1 , Ugt1a1
Diabetes Mellitus, Type 2Abcb1a , Abcc2 , Cyp1a2 , Cyp2e1 , Gstp1 , Gstt1 , Sdf2l1 , Ugt1a1 , Ugt1a6
Diabetic NephropathiesGstt1 , Hspa5
Diabetic RetinopathyGstt1
Disease ProgressionAbcb1a , Abcc1 , Gstp1
Dopamine Beta Hydroxylase DeficiencyHspa5
Drug EruptionsCyp2e1
Drug HypersensitivityAbcc2 , Gstp1 , Gstt1
Drug Metabolism, Poor, CYP2D6-RelatedCyp2d4
Drug-Induced Immune ThrombocytopeniaAbcc2
Drug-Induced Liver InjuryAbcb1a , Abcc1 , Abcc2 , Cyp2e1 , Gstp1 , Gstt1 , Sult1e1 , Ugt1a9
Drug-induced NeutropeniaAbcb1a , Abcc2 , Ugt1a1
Drug-Related Side Effects and Adverse ReactionsAbcb1a , Abcc1 , Abcc2 , Abcc4 , Abcg2 , Cyp1a2 , Cyp2d4 , Cyp2e1 , Ugt1a1
Dyskinesia, Drug-InducedCyp1a2 , Cyp2d4
DystoniaCyp2d4
EncephalitisAbcb1a
Endometrial NeoplasmsSult1a1 , Sult1e1 , Ugt1a1
EndometriosisAbcc4
EndotoxemiaAbcb1a , Abcc2
Enterocolitis, NecrotizingAbcb1a
EosinophiliaAbcb1a
EpilepsyAbcb1a
Epilepsy, Familial Temporal Lobe, 3Abcb1a
Epilepsy, Temporal LobeAbcb1a
Epilepsy, Tonic-ClonicCyp2d4
EpistaxisGstt1
Escherichia Coli InfectionsAbcb1a
Esophageal NeoplasmsAbcb1a , Gstt1
Esophageal Squamous Cell CarcinomaAbcc2 , Gstt1 , Hspa5
Exfoliation SyndromeGstt1
Experimental SeizuresGstp1
Fanconi AnemiaGstt1
Fatty LiverAbcc2 , Abcc3 , Cyp2e1 , Hspa5
Fatty Liver, AlcoholicCyp2e1
Femur Head NecrosisGstt1
Fetal Growth RetardationAbcb1a , Gstt1
Gallbladder NeoplasmsGstp1
GallstonesUgt1a1
Gastrointestinal DiseasesAbcc2
Genetic Predisposition to DiseaseAbcb1a
Genital Neoplasms, FemaleUgt1a1
Gilbert DiseaseUgt1a1 , Ugt1a9
Glaucoma, Primary Open AngleGstt1
GlioblastomaGstt1
GliomaCyp2e1 , Gstp1 , Hspa5
Gram-Negative Bacterial InfectionsUgt1a1
Graves DiseaseGstp1
Growth DisordersCyp1a2
Hearing Loss, Noise-InducedGstt1
Heart Defects, CongenitalAbcb1a , Gstt1
Heart DiseasesAbcb1a , Abcc1 , Abcc2
Hematologic DiseasesGstp1 , Ugt1a1
Hematologic NeoplasmsAbcb1a , Gstt1 , Hspa5
Hepatitis C, ChronicCyp2d4
Hepatitis, AutoimmuneCyp2d4
HepatomegalyCyp1a2
Hirschsprung DiseaseGstt1
HIV InfectionsAbcb1a , Ppib
Hodgkin DiseaseGstp1 , Gstt1 , Ugt1a1
HyperbilirubinemiaAbcc2 , Abcc3 , Ugt1a1 , Ugt1a9
Hyperbilirubinemia, NeonatalUgt1a1
Hyperbilirubinemia, Transient Familial NeonatalUgt1a1 , Ugt1a9
HyperlipidemiasAbcb1a
HyperprolactinemiaAbcc3
HypersensitivityGstp1
HypertensionAbcc1 , Gstt1
HyperthyroidismUgt1a1
HypospadiasGstt1
HypotensionSult1a1
Hypotension, OrthostaticAbcb1a
Infectious MononucleosisGstt1
Infertility, FemaleHspa5
InflammationAbcb1a , Ugt1a1
Inflammatory Bowel Disease 11Gstt1
Inflammatory Bowel Disease 13Abcb1a
Inflammatory Bowel DiseasesGstt1 , Hspa5
Intestinal PolyposisAbcb1a
Iron OverloadGstt1
Ischemic Attack, TransientHspa5
JaundiceCyp1a2
Jaundice, Chronic IdiopathicAbcc2 , Abcc3
KernicterusUgt1a1
Kidney CalculiGstp1
Kidney DiseasesAbcb1a , Abcc3 , Gstp1
Kidney Failure, ChronicAbcb1a , Abcc2 , Abcc3 , Gstt1
Kidney NeoplasmsAbcb1a , Gstt1
Laryngeal NeoplasmsGstp1
LeukemiaGstt1
Leukemia, Lymphocytic, Chronic, B-CellAbcg2
Leukemia, LymphoidGstp1 , Gstt1
Leukemia, Megakaryoblastic, AcuteAbcg2
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveAbcb1a , Abcc2 , Abcg2 , Gstp1 , Hspa5
Leukemia, MyeloidGstp1 , Gstt1 , Ugt1a1
Leukemia, Myeloid, AcuteAbcc3 , Abcg2 , Cyp2d4 , Gstp1 , Gstt1
Leukemia, Promyelocytic, AcuteGstt1
LeukopeniaGstp1 , Gstt1
Liver Cirrhosis, AlcoholicCyp2e1
Liver Cirrhosis, BiliaryAbcc2 , Abcg2
Liver Cirrhosis, ExperimentalAbcb1a , Abcc2 , Abcc5 , Cyp1a2 , Cyp2d4 , Sult1e1 , Sult2a1
Liver DiseasesCyp1a2 , Cyp2e1 , Gstp1 , Sult1e1
Liver Failure, AcuteAbcc2
Liver InjuryAbcg2 , Cyp1a2
Liver NeoplasmsCyp2e1
Liver Neoplasms, ExperimentalCyp1a2 , Cyp2e1 , Gstp1
Lung DiseasesCyp2e1 , Gstp1 , Gstt1
Lung InjuryCyp1a2
Lung NeoplasmsCyp1a2 , Cyp2e1 , Gstp1 , Gstt1
Lymphoma, B-CellAbcg2
Lymphoma, Extranodal NK-T-CellAbcb1a
Lymphoma, Large B-Cell, DiffuseAbcb1a , Abcg2 , Gstp1 , Gstt1
Lymphoma, Non-HodgkinCyp2e1
Macular DegenerationGstt1
Malaria, FalciparumGstp1
Mammary Neoplasms, ExperimentalAbcb1a , Abcg2
Manganese PoisoningCyp2d4
Marijuana AbuseAbcb1a
MedulloblastomaGstt1
MelanomaGstp1
Melanoma, Cutaneous MalignantGstt1
MeningitisGstp1
Mental DisordersAbcb1a
MethemoglobinemiaCyp1a2
Micronuclei, Chromosome-DefectiveCyp2e1 , Gstt1
Motor Neuron DiseaseGstt1
Mouth AbnormalitiesGstt1
Movement DisordersGstp1
Multiple MyelomaAbcg2 , Cyp2d4 , Gstp1 , Gstt1
Multiple SclerosisGstp1 , Gstt1
Muscle RigidityCyp2d4
Myelodysplastic SyndromesGstp1 , Gstt1
Myeloproliferative DisordersHspa5
Myocardial InfarctionHspa5
Myocardial IschemiaGstp1 , Sult1a1
Myocardial Reperfusion InjuryHspa5
Myocarditis, Autoimmune, ExperimentalHspa5
Nasal PolypsAbcb1a , Gstt1
NauseaAbcb1a
NecrosisCyp2e1 , Gstp1
Neoplasm InvasivenessCyp2e1
Neoplasm MetastasisAbcb1a , Abcc4 , Erp29 , Sult1e1
NeoplasmsAbcb1a , Gstt1
Neoplasms, Germ Cell and EmbryonalAbcb1a
Nephritis, InterstitialCyp2d4
Nerve DegenerationHspa5
Nervous System DiseasesAbcb1a , Abcc2 , Abcg2
Neural Tube DefectsCyp1a2
NeuroblastomaAbcb1a
Neuroma, AcousticCyp2e1
Neuronal Ceroid-LipofuscinosesHspa5
Neurotoxicity SyndromesAbcb1a , Abcg2 , Gstp1
NeutropeniaAbcb1a , Gstt1 , Ugt1a1
Non-alcoholic Fatty Liver DiseaseAbcb1a , Abcc3 , Cyp2e1 , Gstp1 , Gstt1
ObesityCyp2e1 , Hspa5
Obesity, MorbidCyp2e1
Occupational DiseasesCyp2d4
Optic NeuritisGstt1
Oral Squamous Cell CarcinomaGstp1
Osteogenesis ImperfectaPpib
Osteogenesis Imperfecta, Type IXPpib
OsteoporosisGstp1
OsteosarcomaGstp1
Ovarian NeoplasmsAbcb1a , Cyp1a2 , Gstp1 , Gstt1 , Sult1a1 , Ugt1a1
Pain, PostoperativeAbcb1a
Pancreatic NeoplasmsAbcc2 , Abcc3 , Abcc5 , Gstp1
Pancreatitis, Experimental, Acute Hspa5
Parkinson DiseaseAbcb1a , Cyp2d4 , Cyp2e1 , Gstp1 , Gstt1
Parkinson Disease, Late-OnsetGstp1
Parkinson Disease, SecondaryAbcb1a
Peripheral Nerve InjuriesHspa5
Peripheral Nervous System DiseasesAbcb1a , Abcc1 , Gstp1 , Gstt1
PeritonitisGstp1
PneumoniaCyp2e1
Pneumonia, BacterialAbcc1
PoisoningAbcb1a
Porphyria Cutanea TardaCyp1a2
Pre-EclampsiaGstp1
Precancerous ConditionsGstp1
Precursor Cell Lymphoblastic Leukemia-LymphomaAbcb1a , Abcc2 , Abcg2 , Cyp1a2 , Cyp2d4 , Gstp1 , Gstt1
Precursor T-Cell Lymphoblastic Leukemia-LymphomaAbcg2
Premature BirthGstt1
Prenatal Exposure Delayed EffectsCyp2d4
PresbycusisGstt1
Prostatic HyperplasiaGstp1
Prostatic Intraepithelial NeoplasiaGstp1
Prostatic NeoplasmsAbcc4 , Cyp2d4 , Cyp2e1 , Erp29 , Gstp1 , Gstt1 , Hsp90b1 , Sdf2l1 , Sult1a1 , Sult1e1 , Sult2a1
Pseudomonas InfectionsGstp1
Pseudoxanthoma ElasticumAbcc1
PsoriasisGstp1
Psychoses, Substance-InducedGstp1
Pulmonary Disease, Chronic ObstructiveAbcc1 , Cyp1a2 , Cyp2e1 , Gstp1 , Gstt1
Pulmonary EmphysemaGstp1
Pulmonary FibrosisGstp1 , Hspa5
Raynaud DiseaseGstt1
Reperfusion InjuryAbcb1a , Abcc5 , Abcg2 , Cyp2e1 , Gstp1 , Hspa5 , Sult1e1
Respiratory HypersensitivityHspa5
Respiratory SoundsGstp1
Respiratory Tract DiseasesGstp1
Rhinitis, AllergicAbcb1a
Rhinitis, Allergic, PerennialGstp1
SarcomaGstp1
SchizophreniaAbcc1 , Gstt1 , Sult1a1
SeizuresAbcb1a , Abcc2 , Hspa5
Senile CataractGstp1
SepsisCyp1a2 , Cyp2e1
Sexual Dysfunctions, PsychologicalCyp2d4
Skin NeoplasmsGstt1
Sleep Apnea, ObstructiveAbcb1a
Smith-Magenis SyndromeAbcc3
Spinal Cord InjuriesHspa5
Spinal Cord Reperfusion InjuryHspa5
Spinocerebellar Ataxia 17Hspa5 , Hyou1
Splenic DiseasesCyp1a2
SplenomegalyCyp1a2
StarvationUgt1a1
Status EpilepticusAbcb1a , Abcc2 , Abcg2
Stomach NeoplasmsGstp1 , Sult1a1
Substance-Related DisordersAbcc4 , Cyp2d4
Testicular NeoplasmsGstp1
Translocation, GeneticAbcb1a
Transplant RejectionGstt1
TremorCyp2d4
Tuberculosis, PulmonaryGstt1
Ureteral CalculiGstp1
URIC ACID CONCENTRATION, SERUM, QUANTITATIVE TRAIT LOCUS 1Abcg2
Urinary Bladder NeoplasmsGstp1 , Gstt1 , Sult1a1
Urologic NeoplasmsSult1a1
Uterine Cervical NeoplasmsGstt1
Venous InsufficiencyGstt1
Vestibular DiseasesGstp1
VomitingAbcb1a
Weight GainCyp2d4
Wet Macular DegenerationGstp1 , Gstt1
Wilms TumorAbcb1a
Pathway Annotations Associated with Genes in the paracetamol pharmacokinetics pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayCyp2e1
antigen processing and presentation pathwayHspa5
antipyrine drug pathwayCyp2e1
arachidonic acid metabolic pathwayCyp2e1
artemether pharmacokinetics pathwayUgt1a9
ascorbate and aldarate metabolic pathwayUgt1a1 , Ugt1a6 , Ugt1a9
azathioprine pharmacodynamics pathwayAbcc4 , Abcc5
bile acid transport pathwayAbcb1a , Abcc2 , Abcc3 , Abcc4 , Abcg2 , Sult2a1
caffeine metabolic pathwayCyp1a2
caffeine pharmacokinetics pathwayCyp1a2 , Cyp2e1
celecoxib pharmacodynamics pathwayCyp2d4 , Cyp2e1
celecoxib pharmacokinetics pathwayCyp2d4
citalopram pharmacodynamics pathwayCyp2d4
citalopram pharmacokinetics pathwayCyp2d4
clomipramine pharmacokinetics pathwayCyp1a2 , Cyp2d4
clopidogrel pharmacodynamics pathwayAbcb1a , Cyp1a2
clopidogrel pharmacokinetics pathwayAbcb1a , Cyp1a2
codeine and morphine pharmacodynamics pathwayCyp2d4 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
codeine and morphine pharmacokinetics pathwayCyp2d4 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
desipramine pharmacodynamics pathwayCyp2d4
desipramine pharmacokinetics pathwayCyp2d4
diclofenac pharmacodynamics pathwayCyp2e1
diflunisal pharmacodynamics pathwayCyp2e1
disulfiram pharmacodynamics pathwayCyp2e1
docetaxel pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
doxepin pharmacokinetics pathwayCyp1a2 , Cyp2d4
doxorubicin pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2
Endoplasmic Reticulum-associated degradation pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia4 , Pdia6
erlotinib pharmacodynamics pathwayAbcb1a , Abcg2
estradiol biosynthetic pathwaySult1e1 , Sult2a1
etodolac pharmacodynamics pathwayCyp2e1
etoposide pharmacodynamics pathwayAbcb1a , Abcc3 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
etoposide pharmacokinetics pathwayAbcb1a , Abcc3 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
felbamate pharmacokinetics pathwayCyp2e1
fenoprofen pharmacodynamics pathwayCyp2e1
fluoxetine pharmacodynamics pathwayCyp2d4
fluoxetine pharmacokinetics pathwayCyp2d4
flurbiprofen pharmacodynamics pathwayCyp2e1
glutathione conjugation pathwayGstp1 , Gstt1
glutathione metabolic pathwayGstp1 , Gstt1
hypoxia inducible factor pathwayAbcb1a , Abcg2
ibuprofen pharmacodynamics pathwayCyp2e1 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
ibuprofen pharmacokinetics pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
imipramine pharmacodynamics pathwayCyp1a2 , Cyp2d4
imipramine pharmacokinetics pathwayCyp1a2 , Cyp2d4
indometacin pharmacodynamics pathwayCyp2e1
indometacin pharmacodynamics pathwayCyp2e1
interleukin-6 signaling pathwayHsp90b1
irinotecan pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
irinotecan pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
ketoprofen pharmacodynamics pathwayCyp2e1
ketorolac pharmacodynamics pathwayCyp2e1
lamivudine pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcc4 , Abcg2 , Sult1a1
leukotriene C4 synthase deficiency pathwayCyp2e1
lidocaine pharmacodynamics pathwayCyp1a2
lidocaine pharmacokinetics pathwayCyp1a2
linoleic acid metabolic pathwayCyp1a2 , Cyp2e1
lornoxicam pharmacodynamics pathwayCyp2e1
magnesium salicylate pharmacodynamics pathwayCyp2e1
mefenamic acid pharmacodynamics pathwayCyp2e1
meloxicam pharmacodynamics pathwayCyp2e1
mercaptopurine pharmacodynamics pathwayAbcc4 , Abcc5
mercaptopurine pharmacokinetics pathwayAbcc4 , Abcc5
methadone pharmacodynamics pathwayCyp2d4
methadone pharmacokinetics pathwayCyp2d4
multidrug resistance-associated protein mediated transport pathwayAbcc1 , Abcc2 , Abcc3 , Abcc4 , Abcc5
mycophenolic acid pharmacokinetics pathwayAbcb1a , Abcc2 , Abcg2 , Ugt1a9
nabumetone pharmacodynamics pathwayCyp2e1
naproxen pharmacodynamics pathwayCyp2e1
neviparine pharmacokinetics pathwayCyp2d4
nicotine pharmacodynamics pathwayUgt1a9
nicotine pharmacokinetics pathwayUgt1a9
NOD-like receptor signaling pathwayHsp90b1
O-linked glycan biosynthetic pathwayUgt1a1 , Ugt1a6 , Ugt1a9
paracetamol drug pathwayCyp2e1
paracetamol pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcc4 , Abcc5 , Abcg2 , Cyp1a2 , Cyp2d4 , Cyp2e1 , Dnajb11 , Erp29 , Gstp1 , Gstt1 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Sult1a1 , Sult1e1 , Sult2a1 , Ugt1a1 , Ugt1a6 , Ugt1a9
paracetamol response pathwayCyp2e1
pentose and glucuronate interconversion pathwayUgt1a1 , Ugt1a6 , Ugt1a9
phase I biotransformation pathway via cytochrome P450Cyp1a2 , Cyp2d4 , Cyp2e1 , Gstp1 , Gstt1 , Ugt1a1 , Ugt1a6 , Ugt1a9
phenytoin pharmacodynamics pathwayCyp1a2 , Cyp2e1 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
piroxicam pharmacodynamics pathwayCyp2e1
porphyrin and chlorophyll metabolic pathwayUgt1a1 , Ugt1a6 , Ugt1a9
prion diseases pathwayHspa5
prostate cancer pathwayGstp1 , Hsp90b1
retinol metabolic pathwayCyp1a2 , Dnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a6 , Ugt1a9
salicylic acid pharmacodynamics pathwayCyp2e1
sodium salicylate pharmacodynamics pathwayCyp2e1
sorafenib pharmacokinetics pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1 , Ugt1a9
sphingosine 1-phosphate signaling pathwayAbcc1
starch and sucrose metabolic pathwayUgt1a1 , Ugt1a6 , Ugt1a9
steroid hormone biosynthetic pathwaySult1e1 , Ugt1a1 , Ugt1a6 , Ugt1a9
sulfite oxidase deficiency pathwaySult1a1 , Sult1e1
sulfur metabolic pathwaySult1a1 , Sult1e1
sulindac pharmacodynamics pathwayCyp2e1
syndecan signaling pathwayPpib
tamoxifen pharmacodynamics pathwayCyp2d4 , Sult1a1
tamoxifen pharmacokinetics pathwayCyp2d4 , Sult1a1 , Sult2a1
tenoxicam pharmacodynamics pathwayCyp2e1
testosterone biosynthetic pathwaySult2a1
tiaprofenic acid pharmacodynamics pathwayCyp2e1
tioguanine pharmacodynamics pathwayAbcc4 , Abcc5
tolmetin pharmacodynamics pathwayCyp2e1
tramadol pharmacokinetics pathwayAbcc2 , Cyp2d4
tryptophan metabolic pathwayCyp1a2
tyrosinemia type III disease pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
valdecoxib pharmacodynamics pathwayCyp2e1
venlafaxine pharmacokinetics pathwayAbcb1a , Cyp2d4
vinblastine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3
vincristine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3
vindesine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3
vinorelbine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3
vitamin A deficiency pathwayDnajb11 , Erp29 , Hsp90b1 , Hspa5 , Hyou1 , Pdia2 , Pdia4 , Pdia6 , Ppib , Sdf2l1 , Ugt1a1
Phenotype Annotations Associated with Genes in the paracetamol pharmacokinetics pathway

References Associated with the paracetamol pharmacokinetics pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: