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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of VEGFB mRNA | CTD | PMID:16214954 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | | 6480464 | Tetrachlorodibenzodioxin affects the expression of VEGFB mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of VEGFB mRNA | CTD | PMID:12167310 PMID:19182260 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of VEGFB mRNA | CTD | PMID:19182260 PMID:12167310 | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of VEGFB mRNA | CTD | PMID:21346803 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of VEGFB mRNA | CTD | PMID:21346803 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of VEGFB mRNA | CTD | PMID:20188158 | aluminium oxide | increases expression | ISO | RGD:1343221 | 6480464 | Aluminum Oxide results in increased expression of VEGFB mRNA | CTD | PMID:19464052 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of VEGFB mRNA | CTD | PMID:16483693 | arsenic atom | affects expression | ISO | RGD:1343221 | 6480464 | Arsenic affects the expression of VEGFB mRNA | CTD | PMID:18414638 | arsenic atom | increases expression | ISO | RGD:1343221 | 6480464 | Arsenic results in increased expression of VEGFB mRNA | CTD | PMID:11134558 | benzo[a]pyrene | multiple interactions | ISO | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of VEGFB mRNA | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | ISO | | 6480464 | Benzo(a)pyrene results in decreased expression of VEGFB mRNA | CTD | PMID:19770486 PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | | 6480464 | Benzo(a)pyrene results in decreased expression of VEGFB mRNA | CTD | PMID:19770486 | bis(2-chloroethyl) sulfide | multiple interactions | ISO | RGD:1343221 | 6480464 | IL10 protein affects the reaction [Mustard Gas affects the expression of VEGFB mRNA] | CTD | PMID:16173061 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | | 6480464 | PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of VEGFB mRNA] | CTD | PMID:19850644 | bis(2-ethylhexyl) phthalate | increases expression | ISO | | 6480464 | Diethylhexyl Phthalate results in increased expression of VEGFB mRNA | CTD | PMID:19850644 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of VEGFB mRNA | CTD | PMID:19167457 | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of VEGFB mRNA | CTD | PMID:21318169 | copper(2+) sulfate | decreases expression | ISO | RGD:1343221 | 6480464 | Copper Sulfate results in decreased expression of VEGFB mRNA | CTD | PMID:19549813 | dioxygen | increases expression | ISO | RGD:1343221 | 6480464 | Oxygen deficiency results in increased expression of VEGFB mRNA | CTD | PMID:17914565 | ethanol | decreases expression | ISO | | 6480464 | Ethanol results in decreased expression of VEGFB mRNA | CTD | PMID:22198099 | fenofibrate | increases expression | EXP | | 6480464 | Fenofibrate results in increased expression of VEGFB mRNA | CTD | PMID:17264098 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of VEGFB gene | CTD | PMID:22079235 | hydralazine | multiple interactions | ISO | RGD:1343221 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of VEGFB mRNA | CTD | PMID:17183730 | hydrogen peroxide | affects expression | ISO | RGD:1343221 | 6480464 | Hydrogen Peroxide affects the expression of VEGFB mRNA | CTD | PMID:20044591 | indole-3-methanol | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of VEGFB mRNA | CTD | PMID:22129741 | N-acetyl-L-cysteine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of VEGFB mRNA | CTD | PMID:22129741 | N-nitrosodiethylamine | increases expression | ISO | | 6480464 | Diethylnitrosamine results in increased expression of VEGFB mRNA | CTD | PMID:18597072 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of VEGFB mRNA | CTD | PMID:22129741 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [gum mastic co-treated with Diethylnitrosamine] results in decreased expression of VEGFB mRNA | CTD | PMID:18977376 | N-nitrosodiethylamine | multiple interactions | ISO | | 6480464 | [troglitazone co-treated with Diethylnitrosamine] results in increased expression of VEGFB mRNA | CTD | PMID:18597072 | phenytoin | decreases expression | ISO | RGD:1343221 | 6480464 | Phenytoin results in decreased expression of VEGFB mRNA | CTD | PMID:14741686 | pirinixic acid | multiple interactions | ISO | RGD:1343221 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of VEGFB mRNA | CTD | PMID:19710929 | pirinixic acid | multiple interactions | ISO | | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in increased expression of VEGFB mRNA] | CTD | PMID:20059764 PMID:17950772 | pirinixic acid | increases expression | ISO | | 6480464 | pirinixic acid results in increased expression of VEGFB mRNA | CTD | PMID:17950772 PMID:20059764 | pirinixic acid | increases expression | ISO | | 6480464 | pirinixic acid results in increased expression of VEGFB mRNA | CTD | PMID:20059764 PMID:17950772 | pirinixic acid | multiple interactions | ISO | | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in increased expression of VEGFB mRNA] | CTD | PMID:17950772 PMID:20059764 | sildenafil | increases expression | EXP | | 6480464 | sildenafil results in increased expression of VEGFB mRNA | CTD | PMID:20583517 | sulfadimethoxine | multiple interactions | EXP | | 6480464 | [Complex Mixtures co-treated with Sulfadimethoxine] results in increased expression of VEGFB mRNA | CTD | PMID:22687987 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of VEGFB mRNA | CTD | PMID:12734012 | troglitazone | multiple interactions | ISO | | 6480464 | [troglitazone co-treated with Diethylnitrosamine] results in increased expression of VEGFB mRNA | CTD | PMID:18597072 | valproic acid | affects expression | ISO | | 6480464 | Valproic Acid affects the expression of VEGFB mRNA | CTD | PMID:17292431 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of VEGFB mRNA | CTD | PMID:21318169 | valproic acid | multiple interactions | ISO | RGD:1343221 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of VEGFB mRNA | CTD | PMID:17183730 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Cytokine-cytokine receptor interaction |
| Focal adhesion | |
| Pathways in cancer | |
| PI3K-Akt signaling pathway | |
| Pathway Interaction Database | VEGFR1 specific signals (PID:200177) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Cytokine-cytokine receptor interaction |
| Focal adhesion | |
| Pathways in cancer | |
| PI3K-Akt signaling pathway | |
| Pathway Interaction Database | VEGFR1 specific signals (PID:200177) |
References - curated| 1. |
Kivela R, etal., FASEB J. 2006 Jul;20(9):1570-2. |
| 2. |
Louzier V, etal., Am J Physiol Lung Cell Mol Physiol. 2003 Jun;284(6):L926-37. Epub 2003 Jan 24. |
| 3. |
McColl BK, etal., APMIS 2004 Jul-Aug;112(7-8):463-80. |
| 4. |
Nag S, etal., J Neuropathol Exp Neurol. 2002 Sep;61(9):778-88. |
| 5. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 6. |
Nishimura J, etal., Toxicol Sci. 2007 May;97(1):44-54. Epub 2007 Jan 29. |
| 7. |
Olsson AK, etal., Nat Rev Mol Cell Biol. 2006 May;7(5):359-71. |
| 8. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 9. |
Rehak M, etal., Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1175-83. Epub 2011 Apr 13. |
| 10. |
RGD automated data pipeline |
| 11. |
RGD automated import pipeline for gene-chemical interactions |
| 12. |
RGD comprehensive gene curation |
| 13. |
Silvestre JS, etal., Circ Res 2003 Jul 25;93(2):114-23. Epub 2003 Jun 12. |
| 14. |
Tirziu D, etal., J Clin Invest. 2007 Nov;117(11):3188-97. |
| 15. |
Zhang F, etal., Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6152-7. Epub 2009 Apr 6. |
References - uncurated
RGD Disease Portals| Vegfb has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Vegfb (Rattus norvegicus) |
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| VEGFB (Homo sapiens) |
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| Vegfb (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_053549 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06009566 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01009342 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009343 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF022952 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF032925 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC076395 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_053549 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_446001 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_446001 | (Get FASTA) |
| GenBank Protein | AAB86884 | (Get FASTA) |
| AAB95447 | (Get FASTA) | |
| AAH76395 | (Get FASTA) | |
| O35485 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000021156 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000049757 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000050891 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 89811 | ENTREZGENE |
| HomoloGene Group ID | 87131 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7109119 | IMAGE-MGC_LOAD |
| InterPro | PD_growth_factor | UniProtKB/Swiss-Prot |
| PD_growth_factor_CS | UniProtKB/Swiss-Prot | |
| IPI | IPI00230953 | UniProtKB/Swiss-Prot |
| IPI00559740 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:89811 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:94837 | IMAGE-MGC_LOAD |
| Pfam | PDGF | UniProtKB/Swiss-Prot |
| PROSITE | PDGF_1 | UniProtKB/Swiss-Prot |
| PDGF_2 | UniProtKB/Swiss-Prot | |
| SMART | PDGF | UniProtKB/Swiss-Prot |
| UniGene | Rn.198550 | ENTREZGENE |
| UniProt | VEGFB_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2005-01-20 | Vegfb | vascular endothelial growth factor B | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2002-08-07 | Vegfb | vascular endothelial growth factor B | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Vegfb | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 619799 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




