Gene: Bpgm (2,3-bisphosphoglycerate mutase)
Rattus norvegicus
Symbol:
Bpgm
Name:
2,3-bisphosphoglycerate mutase
Description:
ENCODES a protein that exhibits phosphoglycerate mutase activity (inferred); INVOLVED IN erythrocyte development; PARTICIPATES IN gluconeogenesis pathway; glycolysis pathway; glycolysis/gluconeogenesis pathway; ASSOCIATED WITH Anemia, Hemolytic, Congenital (ortholog); BISPHOSPHOGLYCERATE MUTASE DEFICIENCY (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; C60 fullerene; (-)-epigallocatechin 3-gallate (ortholog)
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
2,3-bisphosphoglycerate mutase; Ab2-098; bisphosphoglycerate mutase; LOC296973
Orthologs:
Homo sapiens : BPGM
(2,3-bisphosphoglycerate mutase)
HGNC
Bpgm
(2,3-bisphosphoglycerate mutase)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 4 q22 NCBI RGSC Genome Assembly v5.0 4 61,650,881 - 61,679,069 + NCBI RGSC Genome Assembly v3.4 4 61,858,884 - 61,888,007 + NCBI Rat Celera Assembly 4 58,192,196 - 58,220,785 + NCBI Genome Assembly 3.1 4 62,135,013 - 62,164,136 + NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
(-)-epigallocatechin 3-gallate decreases expression ISO RGD:1605438 6480464 epigallocatechin gallate results in decreased expression of BPGM mRNA CTD PMID:16084531 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1551134 6480464 Tetrachlorodibenzodioxin results in increased expression of BPGM mRNA CTD PMID:19933214 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1605438 6480464 Tetrachlorodibenzodioxin results in decreased expression of BPGM mRNA CTD PMID:23152189 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1605438 6480464 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BPGM mRNA]; more ... CTD PMID:23152189 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of BPGM mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of BPGM mRNA] CTD PMID:21215274 3-methylcholanthrene increases expression ISO RGD:1551134 6480464 Methylcholanthrene results in increased expression of BPGM mRNA CTD PMID:20713471 benzo[a]pyrene decreases expression ISO RGD:1551134 6480464 Benzo(a)pyrene results in decreased expression of BPGM mRNA CTD PMID:21569818 benzo[a]pyrene increases expression ISO RGD:1551134 6480464 Benzo(a)pyrene results in increased expression of BPGM mRNA CTD PMID:20713471 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of BPGM mRNA CTD PMID:19167457 copper(2+) sulfate increases expression ISO RGD:1605438 6480464 Copper Sulfate results in increased expression of BPGM mRNA CTD PMID:19549813 dibutyl phthalate increases expression ISO RGD:1551134 6480464 Dibutyl Phthalate results in increased expression of BPGM mRNA CTD PMID:21266533 hydralazine multiple interactions ISO RGD:1605438 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of BPGM mRNA CTD PMID:17183730 N-acetyl-L-cysteine decreases expression ISO RGD:1605438 6480464 Acetylcysteine results in decreased expression of BPGM mRNA CTD PMID:16084531 ozone decreases expression ISO RGD:1551134 6480464 Ozone results in decreased expression of BPGM mRNA CTD PMID:16183385 paracetamol decreases expression ISO RGD:1551134 6480464 Acetaminophen results in decreased expression of BPGM mRNA CTD PMID:17585979 pirinixic acid multiple interactions ISO RGD:1551134 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BPGM mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:1551134 6480464 pirinixic acid results in increased expression of BPGM mRNA CTD PMID:18301758 progesterone affects expression ISO RGD:1551134 6480464 Progesterone affects the expression of BPGM mRNA CTD PMID:17251523 valproic acid multiple interactions ISO RGD:1605438 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of BPGM mRNA CTD PMID:17183730
Biological Process erythrocyte development IDA 1600524 RGD glycolysis IEA UniProtKB-KW:KW-0324 1600115 GO_REF:0000038 UniProtKB GO_REF:0000038 Cellular Component cellular_component ND 1598407 03/2007: no relevant rat data RGD Molecular Function molecular_function ND 1598407 03/2007: no relevant rat data RGD phosphoglycerate mutase activity IEA InterPro:IPR005952 1600115 GO_REF:0000002 InterPro GO_REF:0000002
619616 Bp79 Blood pressure QTL 79 .0292 Blood pressure systolic 4 456799 78039637 Rat 2303168 Bp330 Blood pressure QTL 330 4.25 .017 Blood pressure 4 456799 149181446 Rat 1358203 Stl19 Serum triglyceride level QTL 19 2.8 .002 Lipid level triglyceride 4 460493 64750077 Rat 631261 Tcas3 Tongue tumor susceptibility QTL 3 6 Tongue tumor susceptibility 4 6179441 91330582 Rat 2316958 Gluco58 Glucose level QTL 58 10 Glucose level postprandial 4 6690606 185398530 Rat 1358352 Srcrt3 Stress Responsive Cort QTL 3 2.29 Hypothalamic-pituitary-adrenal axis corticosterone post-stress 4 8819982 149560340 Rat 6909122 Insul22 Insulin level QTL 22 4.63 Insulin level fasting 4 23537363 74625985 Rat 6909128 Pancm4 Pancreatic morphology QTL 4 11.35 Pancreas weight 4 23537363 74625985 Rat 61475 Aia2 Adjuvant induced arthritis QTL 2 5.8 Joint/bone inflammation arthritis severity 4 36592628 73972591 Rat 1331807 Rf31 Renal function QTL 31 2.988 Renal function urine potassium concentration 4 36611842 73752590 Rat 1300139 Hrtrt6 Heart rate QTL 6 2.85 Heart rate salt-loaded 4 36611842 117887968 Rat 61445 Strs3 Sensitivity to stroke QTL 3 3 Stroke susceptibility latency until stroke 4 39146794 84146794 Rat 1576305 Emca6 Estrogen-induced mammary cancer QTL 6 5.8 Mammary tumor susceptibility estradiol-induced 4 41729583 159115617 Rat 1354612 Foco1 Food consumption QTL 1 8.87 Consumption level food intake 4 41729771 151158666 Rat 1354660 Salc1 Saline consumption QTL 1 11.26 Consumption level saline intake 4 41729771 151158666 Rat 6893678 Bw108 Body weight QTL 108 2.6 .006 Body weight salt-loaded 4 42249950 87249950 Rat 2312567 Glom19 Glomerulus QTL 19 1.9 .006 Renal pathology 4 43686352 149560340 Rat 1298082 Stresp4 Stress response QTL 4 Hormone level corticosterone 4 47889730 149560340 Rat 4889969 Bss96 Bone structure and strength QTL 96 4.9 Bone structure 4 54828069 78039637 Rat 4889972 Bss97 Bone structure and strength QTL 97 5.6 Bone structure 4 54828069 78039637 Rat 5685009 Bmd86 Bone mineral density QTL 86 3.7 Bone mineral density areal bone mineral density 4 54828069 78039637 Rat 5685012 Bmd87 Bone mineral density QTL 87 5.1 Bone mineral density bone mineral content 4 54828069 78039637 Rat 70200 Alc18 Alcohol consumption QTL 18 9.2 Consumption level alcohol preference 4 54828166 152570244 Rat 1641833 Alc21 Alcohol consumption QTL 21 8.6 .0001 Consumption level alcohol preference 4 54879077 127941994 Rat 634311 Sach7 Saccharin preference QTL 7 Consumption level saccharin preference 4 55369931 80464927 Rat 631546 Bp86 Blood pressure QTL 86 3.2 Blood pressure systolic 4 55369931 91330856 Rat 61336 Bp21 Blood pressure QTL 21 4.6 Blood pressure salt-loaded systolic 4 55370202 78038013 Rat 1358363 Sradr3 Stress Responsive Adrenal Weight QTL 3 6.19 Hypothalamic-pituitary-adrenal axis adrenal gland weight 4 56690161 101690161 Rat 1558651 Swd3 Spike wave discharge measurement QTL 3 4.62 .000024 Spike wave discharge measurement frequency 4 56704868 91916048 Rat 631671 Iddm11 Insulin dependent diabetes mellitus QTL 11 3.6 .0012 Glucose level 4 56920444 78042833 Rat 738009 Sach4 Saccharine consumption QTL 4 4.9 .000016 Consumption level saccharin preference 4 58421110 158108528 Rat 738016 Alc16 Alcohol consumption QTL 16 3.6 .00015 Consumption level alcohol preference 4 58421110 158108528 Rat 738031 Alc14 Alcohol consumption QTL 14 7.6 .00003 Consumption level alcohol preference 4 58421110 158108528 Rat 634344 Hcar7 Hepatocarcinoma resistance QTL 7 7.8 Liver tumor resistance 3-methyl-4-dimethylaminoazobenzene induced 4 58550170 93498821 Rat 2300179 Bmd50 Bone mineral density QTL 50 5.9 .0001 Bone mineral density 4 60200806 105200806 Rat 1549843 Bw53 Body weight QTL 53 .0001 Body weight 4 60262965 104415981 Rat 1549839 Bw52 Body weight QTL 52 .0001 Body weight 4 60262965 116780394 Rat 61418 Pia5 Pristane induced arthritis QTL 5 4.5 Joint/bone inflammation inflammation score 4 60974346 130228614 Rat 1578657 Bss12 Bone structure and strength QTL 12 8.9 Bone structure femoral neck total area 4 61483655 106483655 Rat 1578658 Bss13 Bone structure and strength QTL 13 8 Bone structure femoral neck polar moment of inertia (Ip) 4 61483655 106483655 Rat 70192 BpQTLcluster5 Blood pressure QTL cluster 5 2.6 Blood pressure 4 61646915 116611046 Rat
Gene-Chemical Interaction Annotations
