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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1558563 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATG12 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1558563 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATG12 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1558563 | 6480464 | Tetrachlorodibenzodioxin affects the expression of ATG12 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1558563 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ATG12 mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1558563 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ATG12 mRNA | CTD | PMID:15328365 | 5-fluorouracil | decreases expression | ISO | RGD:1314851 | 6480464 | Fluorouracil results in decreased expression of ATG12 mRNA | CTD | PMID:16510598 | benzo[a]pyrene | multiple interactions | ISO | RGD:1558563 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of ATG12 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | ISO | RGD:1558563 | 6480464 | Benzo(a)pyrene results in increased expression of ATG12 mRNA | CTD | PMID:22228805 | chloramphenicol | increases expression | ISO | RGD:1314851 | 6480464 | Chloramphenicol results in increased expression of ATG12 mRNA | CTD | PMID:17457038 | cisplatin | decreases expression | ISO | RGD:1558563 | 6480464 | Cisplatin results in decreased expression of ATG12 mRNA | CTD | PMID:21151649 | cobalt dichloride | increases expression | ISO | RGD:1314851 | 6480464 | cobaltous chloride results in increased expression of ATG12 mRNA | CTD | PMID:19376846 | copper(2+) sulfate | increases expression | ISO | RGD:1314851 | 6480464 | Copper Sulfate results in increased expression of ATG12 mRNA | CTD | PMID:19549813 | elemental selenium | decreases expression | ISO | RGD:1314851 | 6480464 | Selenium results in decreased expression of ATG12 mRNA | CTD | PMID:19244175 | fenofibrate | increases expression | ISO | RGD:1558563 | 6480464 | Fenofibrate results in increased expression of ATG12 mRNA | CTD | PMID:21318169 | fenofibrate | multiple interactions | ISO | RGD:1558563 | 6480464 | PPARA protein affects the reaction [Fenofibrate results in increased expression of ATG12 mRNA] | CTD | PMID:21318169 | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of ATG12 mRNA | CTD | PMID:20080153 | maneb | multiple interactions | ISO | RGD:1558563 | 6480464 | Maneb promotes the reaction [Paraquat results in increased expression of ATG12 protein] | CTD | PMID:22292029 | N-acetyl-L-cysteine | multiple interactions | ISO | RGD:1314851 | 6480464 | Acetylcysteine inhibits the reaction [vorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]] | CTD | PMID:20543569 | paracetamol | affects expression | ISO | RGD:1558563 | 6480464 | Acetaminophen affects the expression of ATG12 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:1314851 | 6480464 | Acetaminophen results in increased expression of ATG12 mRNA | CTD | PMID:21420995 | paraquat | increases expression | ISO | RGD:1558563 | 6480464 | Paraquat results in increased expression of ATG12 protein | CTD | PMID:22292029 | paraquat | multiple interactions | ISO | RGD:1558563 | 6480464 | Maneb promotes the reaction [Paraquat results in increased expression of ATG12 protein] | CTD | PMID:22292029 | phenobarbital | affects expression | ISO | RGD:1314851 | 6480464 | Phenobarbital affects the expression of ATG12 mRNA | CTD | PMID:19159669 | pirinixic acid | increases expression | ISO | RGD:1558563 | 6480464 | pirinixic acid results in increased expression of ATG12 mRNA | CTD | PMID:18301758 PMID:20813756 | pirinixic acid | increases expression | ISO | RGD:1558563 | 6480464 | pirinixic acid results in increased expression of ATG12 mRNA | CTD | PMID:18301758 more ... | pirinixic acid | increases expression | ISO | RGD:1558563 | 6480464 | pirinixic acid results in increased expression of ATG12 mRNA | CTD | PMID:21318169 more ... | pirinixic acid | increases expression | ISO | RGD:1558563 | 6480464 | pirinixic acid results in increased expression of ATG12 mRNA | CTD | PMID:20813756 more ... | pirinixic acid | multiple interactions | ISO | RGD:1558563 | 6480464 | PPARA protein affects the reaction [pirinixic acid results in increased expression of ATG12 mRNA] | CTD | PMID:21318169 | pirinixic acid | increases expression | ISO | RGD:1558563 | 6480464 | pirinixic acid results in increased expression of ATG12 mRNA | CTD | PMID:21318169 more ... | pirinixic acid | increases expression | ISO | RGD:1558563 | 6480464 | pirinixic acid results in increased expression of ATG12 mRNA | CTD | PMID:20813756 PMID:18301758 | selenium atom | decreases expression | ISO | RGD:1314851 | 6480464 | Selenium results in decreased expression of ATG12 mRNA | CTD | PMID:19244175 | staurosporine | affects response to substance | ISO | RGD:1314851 | 6480464 | ATG12 protein affects the susceptibility to Staurosporine | CTD | PMID:16497721 | valproic acid | increases expression | ISO | RGD:1558563 | 6480464 | Valproic Acid results in increased expression of ATG12 mRNA | CTD | PMID:20546886 | zinc atom | multiple interactions | ISO | RGD:1314851 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of ATG12 mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | RGD:1314851 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of ATG12 mRNA | CTD | PMID:18593933 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Regulation of autophagy |
| RIG-I-like receptor signaling pathway | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Regulation of autophagy |
| RIG-I-like receptor signaling pathway | |
References - curated
References - uncurated
RGD Disease Portals| Atg12 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Atg12 (Rattus norvegicus) |
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| ATG12 (Homo sapiens) |
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| Atg12 (Mus musculus) |
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Position Markers| RH138037 |
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| RH129009 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| RefSeq Acc Id: | NM_001038495 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001033584 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001033584 | (Get FASTA) |
| GenBank Protein | AAH87139 | (Get FASTA) |
| AAI10057 | (Get FASTA) | |
| EDM14400 | (Get FASTA) | |
| Q2TBJ5 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000000157 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000000170 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000000170 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 361321 | ENTREZGENE |
| Germonline | ENSRNOG00000000157 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 37953 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7126298 | IMAGE-MGC_LOAD |
| IMAGE:7443799 | IMAGE-MGC_LOAD | |
| InterPro | Autophagy-rel_prot_12 | UniProtKB/Swiss-Prot |
| IPI | IPI00211923 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:361321 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:125080 | IMAGE-MGC_LOAD |
| MGC:95084 | IMAGE-MGC_LOAD | |
| PANTHER | APG12 | UniProtKB/Swiss-Prot |
| Pfam | APG12 | UniProtKB/Swiss-Prot |
| UniGene | Rn.6224 | ENTREZGENE |
| UniProt | ATG12_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2012-06-07 | Atg12 | autophagy related 12 | Atg12 | autophagy related 12 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2012-06-07 | Atg12 | autophagy related 12 | Atg12 | ATG12 autophagy related 12 homolog (S. cerevisiae) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2012-06-07 | Atg12 | autophagy related 12 | Atg12 | autophagy related 12 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-09-25 | Atg12 | ATG12 autophagy related 12 homolog (S. cerevisiae) | Atg12 | autophagy-related 12 (yeast) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-03-30 | Atg12 | autophagy-related 12 (yeast) | Apg12l | autophagy 12-like (S. cerevisiae) | Symbol and Name updated | 10779 | APPROVED |
| 2005-12-06 | Apg12l | autophagy 12-like (S. cerevisiae) | Apg12l_predicted | autophagy 12-like (S. cerevisiae) (predicted) | Symbol and Name updated | 14393 | APPROVED |
| 2005-01-12 | Apg12l_predicted | autophagy 12-like (S. cerevisiae) (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Atg12 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1306306 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




