Gene: Ren (renin) Rattus norvegicus
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Symbol: Ren
Name: renin
Description: ENCODES a protein that exhibits endopeptidase activity; insulin-like growth factor receptor binding; receptor binding; INVOLVED IN amyloid-beta metabolic process; angiotensin maturation; cellular response to drug; PARTICIPATES IN renin-angiotensin cascade pathway; benazepril pharmacodynamics pathway; candesartan pharmacodynamics pathway; ASSOCIATED WITH albuminuria; increased systemic arterial blood pressure; salt-sensitive hypertension; ASSOCIATED WITH Diabetic Nephropathies; Hypertension; hypertension; FOUND IN cytoplasm; extracellular space; apical part of cell (ortholog); INTERACTS WITH 11-deoxycorticosterone; 2,4-dinitrotoluene; 2,6-dinitrotoluene
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: angiotensinogenase; RATRENAA; Ren1; RENAA; renin 1; renin 1 structural
Orthologs:
Homo sapiens (human) : REN (renin)  HGNC  AGR
Mus musculus (house mouse) : Ren1 (renin 1 structural)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Ren (renin)
Pan paniscus (bonobo/pygmy chimpanzee) : REN (renin)
Canis lupus familiaris (dog) : REN (renin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ren (renin)
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Allele / Splice: Renem1Mcwi  
Genetic Models: SS-Renem1Mcwi
Is Marker For: Strains:   SHR.BN-(D13Arb5-Ren1)/Ipcv   SS.BN-(D13Rat20-D13Rat127)/Mcwi   SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi  
QTLs:   Bp24   Bp5  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01350,502,724 - 50,513,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01355,555,583 - 55,566,812 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,262,936 - 46,275,213 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11346,277,000 - 46,288,249 (+)NCBI
Celera1345,129,122 - 45,139,889 (+)NCBICelera
Cytogenetic Map13q13NCBI
RH 3.4 Map13170.9RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Protein Structures
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ren
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3554
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-11-07
Status: ACTIVE