Gene: Ren (renin)  Rattus norvegicus Symbol: Ren Name: renin Description: ENCODES a protein that exhibits endopeptidase activity; insulin-like growth factor receptor binding; receptor binding; INVOLVED IN angiotensin maturation; beta-amyloid metabolic process; cellular response to drug; PARTICIPATES IN renin-angiotensin cascade pathway; ASSOCIATED WITH increased systemic arterial blood pressure; ASSOCIATED WITH Diabetic Nephropathies; Hypertension; Hypertrophy, Left Ventricular; FOUND IN cytoplasmic part; extracellular space; intracellular (ortholog); INTERACTS WITH 11-deoxycorticosterone; 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]; 2,4-dinitrotoluene Type: protein-coding RefSeq Status: PROVISIONAL Also known as: angiotensinogenase; RATRENAA; Ren1; RENAA; renin; renin 1; renin 1 structural Orthologs: Homo sapiens : REN (renin)  HGNC Mus musculus : Ren1 (renin 1 structural)  MGI Allele / Splice: Renem1Mcwi   Is Marker For: Strains:   SHR.BN-(D13Arb5-Ren1)/Ipcv   QTLs:   Bp24   Bp5   Latest Assembly: RGSC Genome Assembly v3.4 Position: Map Chr Position Strand Source Rat Cytogenetic Map 13 q13   NCBI RGSC Genome Assembly v5.0 13 55,555,583 - 55,566,812 - NCBI RGSC Genome Assembly v3.4 13 46,262,936 - 46,275,213 + NCBI Rat Celera Assembly 13 45,129,122 - 45,139,889 + NCBI Genome Assembly 3.1 13 46,277,000 - 46,288,249 + NCBI RH 3.4 13 170.9   RGD Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Atrial Fibrillation   ISS RGD:736366 6892701 associated with Rheumatic Heart Disease; more ... RGD   Cardiomegaly   ISS RGD:1332384 6771378 mRNA:increased expression:heart, kidney (mouse) RGD   Diabetic Nephropathies   IED   1579795   RGD   Fatigue Syndrome, Chronic   ISS RGD:736366 6892702 associated with Postural Orthostatic Tachycardia Syndrome; more ... RGD   Hypertension   ISS RGD:1332384 6784501   RGD   Hypertension   ISS RGD:1332384 6892655 protein:decreased activity:plasma (mouse) RGD   Hypertension   ISS RGD:736366 1580697   RGD   Hypertension   IED   1580671 RGD   Hypertension, Portal   ISS RGD:736366 1580698   RGD   Hypertension, Renovascular   ISS RGD:1332384 6892688 mRNA:increased expression:renal cortex (mouse) RGD   Hypertrophy, Left Ventricular   IEP   6771379 protein:decreased activity:plasma (rat) RGD   HYPERURICEMIC NEPHROPATHY, FAMILIAL JUVENILE, 2   ISS RGD:736366 7240710   OMIM   Kidney Diseases   ISS RGD:736366 1598878 renal tubular dysgenesis,OMIM:267430;DNA:point mutation:exon:R49X RGD   Liver Cirrhosis, Biliary   IEP   6892690 protein:increased activity:plasma (rat) RGD   Myocardial Infarction Susceptibility ISS RGD:736366 6892687 associated with Hypertension; more ... RGD   Obesity   ISS RGD:736366 6784503 mRNA:increased expression:abdomen, subcutaneous adipose tissue, mesenchymal stem cell (human) RGD   RENAL TUBULAR DYSGENESIS   ISS RGD:736366 1598878 DNA:polymorphisms:cds, intron:multiple (human) RGD   RENAL TUBULAR DYSGENESIS   ISS RGD:736366 7240710   OMIM   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (R)-adrenaline increases activity ISO RGD:736366 6480464 Epinephrine results in increased activity of REN protein CTD PMID:8592096 PMID:6314140 (R)-adrenaline increases activity ISO RGD:736366 6480464 Epinephrine results in increased activity of REN protein CTD PMID:6314140 PMID:8592096 (R)-adrenaline multiple interactions ISO RGD:736366 6480464 ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein] CTD PMID:6314140 11-deoxycorticosterone multiple interactions EXP   6480464 [Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of REN protein CTD PMID:11039 17alpha-ethynylestradiol multiple interactions ISO RGD:736366 6480464 AGT gene polymorphism promotes the reaction [Ethinyl Estradiol results in increased activity of REN protein]; more ... CTD PMID:11095476 17alpha-ethynylestradiol increases activity ISO RGD:736366 6480464 Ethinyl Estradiol results in increased activity of REN protein CTD PMID:11095476 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] multiple interactions EXP   6480464 nebivolol inhibits the reaction [Nitric Oxide deficiency results in increased expression of REN protein] CTD PMID:12806161 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1332384 6480464 AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of REN1 mRNA] CTD PMID:12151645 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1332384 6480464 Tetrachlorodibenzodioxin results in decreased expression of REN1 mRNA CTD PMID:12151645 PMID:12215675 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1332384 6480464 Tetrachlorodibenzodioxin results in decreased expression of REN1 mRNA CTD PMID:12215675 PMID:12151645 2,4-dinitrotoluene affects expression EXP   6480464 2,4-dinitrotoluene affects the expression of REN1 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP   6480464 2,6-dinitrotoluene affects the expression of REN1 mRNA CTD PMID:21346803 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine multiple interactions EXP   6480464 Puromycin Aminonucleoside affects the expression of and affects the activity of REN protein CTD PMID:8446257 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression EXP   6480464 Puromycin Aminonucleoside results in increased expression of REN protein CTD PMID:2267444 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine multiple interactions EXP   6480464 Puromycin Aminonucleoside results in increased expression of and results in increased activity of REN protein CTD PMID:2236972 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine affects expression EXP   6480464 Puromycin Aminonucleoside affects the expression of REN protein CTD PMID:9171944 6alpha-methylprednisolone increases activity EXP   6480464 Methylprednisolone results in increased activity of REN protein CTD PMID:235222 PMID:6277579 6alpha-methylprednisolone increases activity EXP   6480464 Methylprednisolone results in increased activity of REN protein CTD PMID:6277579 PMID:235222 6alpha-methylprednisolone multiple interactions EXP   6480464 Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein] CTD PMID:235222 acebutolol decreases activity ISO RGD:736366 6480464 Acebutolol results in decreased activity of REN protein CTD PMID:6118215 acebutolol decreases activity EXP   6480464 Acebutolol results in decreased activity of REN protein CTD PMID:6110712 acetylsalicylic acid decreases activity ISO RGD:736366 6480464 Aspirin results in decreased activity of REN protein CTD PMID:7994448 PMID:19805643 acetylsalicylic acid decreases activity ISO RGD:736366 6480464 Aspirin results in decreased activity of REN protein CTD PMID:19805643 PMID:7994448 actinomycin D multiple interactions ISO RGD:736366 6480464 Dactinomycin inhibits the reaction [Terbutaline results in increased secretion of REN protein]; more ... CTD PMID:9203624 adenosine decreases secretion EXP   6480464 Adenosine results in decreased secretion of REN protein CTD PMID:3044993 albuterol increases expression ISO RGD:736366 6480464 Albuterol results in increased expression of REN protein CTD PMID:2829953 aldosterone multiple interactions ISO RGD:736366 6480464 [AGT co-treated with REN] results in increased abundance of Aldosterone; more ... CTD PMID:18679781 all-trans-retinoic acid decreases expression ISO RGD:1332384 6480464 Tretinoin results in decreased expression of REN1 mRNA CTD PMID:16604517 alpha-methyl-L-dopa decreases activity EXP   6480464 Methyldopa results in decreased activity of REN protein CTD PMID:145319 alprenolol decreases expression ISO RGD:736366 6480464 Alprenolol results in decreased expression of REN protein CTD PMID:923630 alprenolol multiple interactions ISO RGD:736366 6480464 Alprenolol inhibits the reaction [Hydralazine results in increased expression of REN protein] CTD PMID:923630 aluminium phosphide increases activity ISO RGD:736366 6480464 aluminum phosphide results in increased activity of REN protein CTD PMID:2200784 amlodipine multiple interactions ISO RGD:736366 6480464 [Indomethacin co-treated with Amlodipine] results in decreased expression of REN protein CTD PMID:11078175 ammonium chloride affects expression EXP   6480464 Ammonium Chloride affects the expression of REN mRNA CTD PMID:16483693 atenolol multiple interactions ISO RGD:736366 6480464 [aliskiren co-treated with Atenolol] results in decreased activity of REN protein CTD PMID:18957387 atenolol decreases activity ISO RGD:736366 6480464 Atenolol results in decreased activity of REN protein CTD PMID:3333524 PMID:18957387 atenolol decreases expression EXP   6480464 Atenolol results in decreased expression of REN protein CTD PMID:9300315 atenolol multiple interactions EXP   6480464 Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein]; more ... CTD PMID:9300315 atenolol multiple interactions ISO RGD:736366 6480464 [Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein CTD PMID:3142437 atenolol decreases expression ISO RGD:736366 6480464 Atenolol results in decreased expression of REN protein CTD PMID:14639093 atenolol decreases activity ISO RGD:736366 6480464 Atenolol results in decreased activity of REN protein CTD PMID:18957387 PMID:3333524 benazepril increases expression ISO RGD:736366 6480464 benazepril results in increased expression of REN protein CTD PMID:1316404 benazepril increases activity EXP   6480464 benazepril results in increased activity of REN protein CTD PMID:11501062 benazepril multiple interactions EXP   6480464 [benazepril co-treated with valsartan] results in increased activity of REN protein CTD PMID:11501062 benazepril multiple interactions ISO RGD:736366 6480464 [benazepril co-treated with valsartan] results in increased activity of REN protein CTD PMID:10836730 bendroflumethiazide increases expression ISO RGD:736366 6480464 Bendroflumethiazide results in increased expression of REN protein CTD PMID:62162 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1332384 6480464 PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of REN1 mRNA] CTD PMID:19850644 bis(2-ethylhexyl) phthalate affects expression EXP   6480464 Diethylhexyl Phthalate affects the expression of REN protein CTD PMID:22677342 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1332384 6480464 Diethylhexyl Phthalate results in decreased expression of REN1 mRNA CTD PMID:19850644 bucladesine increases secretion ISO RGD:736366 6480464 Bucladesine results in increased secretion of REN protein CTD PMID:9256163 bucladesine increases expression ISO RGD:736366 6480464 Bucladesine results in increased expression of REN mRNA CTD PMID:9256163 bumetanide multiple interactions ISO RGD:736366 6480464 [Bumetanide co-treated with trandolapril] results in increased expression of REN protein CTD PMID:16635047 bumetanide increases expression ISO RGD:1332384 6480464 Bumetanide results in increased expression of REN mRNA CTD PMID:14504926 bumetanide multiple interactions ISO RGD:736366 6480464 Indomethacin inhibits the reaction [Bumetanide results in increased activity of REN protein] CTD PMID:6756707 bumetanide multiple interactions ISO RGD:736366 6480464 Probenecid inhibits the reaction [Bumetanide results in increased secretion of REN protein] CTD PMID:7040495 bumetanide increases secretion ISO RGD:736366 6480464 Bumetanide results in increased secretion of REN protein CTD PMID:7040495 bumetanide increases expression ISO RGD:736366 6480464 Bumetanide results in increased expression of REN protein CTD PMID:16635047 caffeine increases activity EXP   6480464 Caffeine results in increased activity of REN protein CTD PMID:3020089 PMID:1860718 caffeine increases secretion EXP   6480464 Caffeine results in increased secretion of REN protein CTD PMID:10803761 caffeine increases activity EXP   6480464 Caffeine results in increased activity of REN protein CTD PMID:1860718 PMID:3020089 caffeine increases activity ISO RGD:736366 6480464 Caffeine results in increased activity of REN protein CTD PMID:8244516 caffeine increases expression EXP   6480464 Caffeine results in increased expression of REN protein CTD PMID:3044993 calcitriol decreases activity ISO RGD:736366 6480464 Calcitriol results in decreased activity of REN protein CTD PMID:10052739 calcium atom decreases secretion EXP   6480464 Calcium results in decreased secretion of REN protein CTD PMID:9618396 calcium atom multiple interactions EXP   6480464 [[Calcium results in increased activity of MYLK protein] which results in increased phosphorylation of MYL9 protein] which results in decreased secretion of REN protein; more ... CTD PMID:9618396 calcium(0) decreases secretion EXP   6480464 Calcium results in decreased secretion of REN protein CTD PMID:9618396 calcium(0) multiple interactions EXP   6480464 [[Calcium results in increased activity of MYLK protein] which results in increased phosphorylation of MYL9 protein] which results in decreased secretion of REN protein; more ... CTD PMID:9618396 candesartan increases expression EXP   6480464 candesartan results in increased expression of REN mRNA CTD PMID:19047581 PMID:18796534 candesartan increases expression EXP   6480464 candesartan results in increased expression of REN mRNA CTD PMID:18796534 PMID:19047581 candesartan decreases activity ISO RGD:736366 6480464 candesartan results in decreased activity of REN protein CTD PMID:18679781 candesartan multiple interactions ISO RGD:736366 6480464 candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone] CTD PMID:18679781 carvedilol decreases expression ISO RGD:736366 6480464 carvedilol results in decreased expression of REN protein CTD PMID:2454358 celecoxib decreases expression EXP   6480464 celecoxib results in decreased expression of REN protein CTD PMID:10742298 CGS-21680 multiple interactions EXP   6480464 Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein] CTD PMID:9300315 CGS-21680 increases expression EXP   6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein CTD PMID:9300315 chlorthalidone increases expression ISO RGD:736366 6480464 Chlorthalidone results in increased expression of REN protein modified form CTD PMID:796642 chlorthalidone increases activity ISO RGD:736366 6480464 Chlorthalidone results in increased activity of REN protein CTD PMID:1116335 PMID:3319646 chlorthalidone increases activity ISO RGD:736366 6480464 Chlorthalidone results in increased activity of REN protein CTD PMID:3319646 PMID:1116335 choline multiple interactions ISO RGD:1332384 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of REN1 mRNA CTD PMID:20938992 cis-ketoconazole decreases expression ISO RGD:736366 6480464 Ketoconazole results in decreased expression of REN protein CTD PMID:2632720 clofibrate multiple interactions ISO RGD:1332384 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of REN1 mRNA; more ... CTD PMID:17585979 clonidine decreases activity ISO RGD:736366 6480464 Clonidine results in decreased activity of REN protein CTD PMID:6337028 more ... clonidine increases activity ISO RGD:736366 6480464 Clonidine results in increased activity of REN protein CTD PMID:7837211 PMID:3007707 clonidine decreases activity ISO RGD:736366 6480464 Clonidine results in decreased activity of REN protein CTD PMID:6337028 more ... clonidine decreases expression ISO RGD:736366 6480464 Clonidine results in decreased expression of REN protein CTD PMID:20833658 PMID:3913757 clonidine decreases activity ISO RGD:736366 6480464 Clonidine results in decreased activity of REN protein CTD PMID:238481 more ... clonidine decreases activity ISO RGD:736366 6480464 Clonidine results in decreased activity of REN protein CTD PMID:238481 more ... clonidine multiple interactions ISO RGD:736366 6480464 [Clonidine co-treated with Spironolactone] results in decreased expression of REN protein CTD PMID:12014310 clonidine increases activity ISO RGD:736366 6480464 Clonidine results in increased activity of REN protein CTD PMID:3007707 PMID:7837211 clonidine decreases expression ISO RGD:736366 6480464 Clonidine results in decreased expression of REN protein CTD PMID:3913757 PMID:20833658 clonidine (amino form) decreases activity ISO RGD:736366 6480464 Clonidine results in decreased activity of REN protein CTD PMID:6337028 more ... clonidine (amino form) increases activity ISO RGD:736366 6480464 Clonidine results in increased activity of REN protein CTD PMID:7837211 PMID:3007707 clonidine (amino form) decreases activity ISO RGD:736366 6480464 Clonidine results in decreased activity of REN protein CTD PMID:6337028 more ... clonidine (amino form) decreases expression ISO RGD:736366 6480464 Clonidine results in decreased expression of REN protein CTD PMID:20833658 PMID:3913757 clonidine (amino form) decreases activity ISO RGD:736366 6480464 Clonidine results in decreased activity of REN protein CTD PMID:238481 more ... clonidine (amino form) decreases activity ISO RGD:736366 6480464 Clonidine results in decreased activity of REN protein CTD PMID:238481 more ... clonidine (amino form) multiple interactions ISO RGD:736366 6480464 [Clonidine co-treated with Spironolactone] results in decreased expression of REN protein CTD PMID:12014310 clonidine (amino form) increases activity ISO RGD:736366 6480464 Clonidine results in increased activity of REN protein CTD PMID:3007707 PMID:7837211 clonidine (amino form) decreases expression ISO RGD:736366 6480464 Clonidine results in decreased expression of REN protein CTD PMID:3913757 PMID:20833658 clonidine (imino form) decreases activity ISO RGD:736366 6480464 Clonidine results in decreased activity of REN protein CTD PMID:6337028 more ... clonidine (imino form) increases activity ISO RGD:736366 6480464 Clonidine results in increased activity of REN protein CTD PMID:7837211 PMID:3007707 clonidine (imino form) decreases activity ISO RGD:736366 6480464 Clonidine results in decreased activity of REN protein CTD PMID:6337028 more ... clonidine (imino form) decreases expression ISO RGD:736366 6480464 Clonidine results in decreased expression of REN protein CTD PMID:20833658 PMID:3913757 clonidine (imino form) decreases activity ISO RGD:736366 6480464 Clonidine results in decreased activity of REN protein CTD PMID:238481 more ... clonidine (imino form) decreases activity ISO RGD:736366 6480464 Clonidine results in decreased activity of REN protein CTD PMID:238481 more ... clonidine (imino form) multiple interactions ISO RGD:736366 6480464 [Clonidine co-treated with Spironolactone] results in decreased expression of REN protein CTD PMID:12014310 clonidine (imino form) increases activity ISO RGD:736366 6480464 Clonidine results in increased activity of REN protein CTD PMID:3007707 PMID:7837211 clonidine (imino form) decreases expression ISO RGD:736366 6480464 Clonidine results in decreased expression of REN protein CTD PMID:3913757 PMID:20833658 cortisol decreases expression ISO RGD:736366 6480464 Hydrocortisone results in decreased expression of REN protein CTD PMID:7473517 PMID:15743397 cortisol decreases expression ISO RGD:736366 6480464 Hydrocortisone results in decreased expression of REN protein CTD PMID:15743397 PMID:7473517 cycloheximide multiple interactions ISO RGD:736366 6480464 Cycloheximide inhibits the reaction [Terbutaline results in increased secretion of REN protein]; more ... CTD PMID:9203624 cyclosporin A affects expression ISO RGD:736366 6480464 Cyclosporine affects the expression of REN protein CTD PMID:1851318 cyclosporin A increases expression EXP   6480464 Cyclosporine results in increased expression of REN protein CTD PMID:21865292 PMID:7532090 cyclosporin A increases expression EXP   6480464 Cyclosporine results in increased expression of REN mRNA CTD PMID:21865292 cyclosporin A increases expression EXP   6480464 Cyclosporine results in increased expression of REN protein CTD PMID:7532090 PMID:21865292 cyclosporin A increases expression EXP   6480464 Cyclosporine results in increased expression of REN protein CTD PMID:7532090 cyclosporin A decreases activity ISO RGD:736366 6480464 Cyclosporine results in decreased activity of REN protein CTD PMID:3300326 D-glucose increases expression EXP   6480464 Glucose results in increased expression of REN mRNA; more ... CTD PMID:19861503 desflurane multiple interactions ISO RGD:736366 6480464 [Propofol co-treated with desflurane] results in increased expression of REN protein CTD PMID:8017643 dexamethasone multiple interactions ISO RGD:736366 6480464 [Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein CTD PMID:3142437 dexamethasone increases secretion EXP   6480464 Dexamethasone results in increased secretion of REN protein CTD PMID:3074918 dexamethasone increases activity ISO RGD:736366 6480464 Dexamethasone results in increased activity of REN protein CTD PMID:174842 diazoxide increases activity ISO RGD:736366 6480464 Isoproterenol results in increased activity of REN protein CTD PMID:6314140 diazoxide increases expression EXP   6480464 Isoproterenol results in increased expression of REN protein CTD PMID:9539862 PMID:11709406 diazoxide increases expression ISO RGD:1332384 6480464 Isoproterenol results in increased expression of REN mRNA CTD PMID:21424707 diazoxide multiple interactions EXP   6480464 Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein] CTD PMID:9539862 diazoxide multiple interactions EXP   6480464 Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]; more ... CTD PMID:11709406 diazoxide increases expression EXP   6480464 Isoproterenol results in increased expression of REN protein CTD PMID:11709406 PMID:9539862 diazoxide increases secretion EXP   6480464 Isoproterenol results in increased secretion of REN protein CTD PMID:3910304 diazoxide increases secretion ISO RGD:1332384 6480464 Isoproterenol results in increased secretion of REN protein CTD PMID:3515047 diazoxide multiple interactions ISO RGD:736366 6480464 Propranolol inhibits the reaction [Isoproterenol results in increased expression of REN protein] CTD PMID:1653766 diazoxide increases expression ISO RGD:736366 6480464 Isoproterenol results in increased expression of REN protein CTD PMID:1653766 diethylstilbestrol increases activity ISO RGD:736366 6480464 Diethylstilbestrol results in increased activity of REN protein CTD PMID:45830 diltiazem increases expression ISO RGD:736366 6480464 Diltiazem results in increased expression of REN protein CTD PMID:2222951 dobutamine multiple interactions ISO RGD:736366 6480464 Cycloheximide inhibits the reaction [Dobutamine results in increased secretion of REN protein]; more ... CTD PMID:9203624 dobutamine increases expression ISO RGD:736366 6480464 Dobutamine results in increased expression of REN mRNA CTD PMID:9203624 dobutamine increases secretion ISO RGD:736366 6480464 Dobutamine results in increased secretion of REN protein CTD PMID:9203624 dobutamine increases activity ISO RGD:736366 6480464 Dobutamine results in increased activity of REN protein CTD PMID:9209250 doxazosin increases expression ISO RGD:736366 6480464 Doxazosin results in increased expression of REN protein CTD PMID:7818152 doxorubicin increases expression ISO RGD:1332384 6480464 Doxorubicin results in increased expression of REN1 mRNA CTD PMID:15033991 enalapril multiple interactions ISO RGD:736366 6480464 [Indomethacin co-treated with Enalapril] results in decreased expression of REN protein CTD PMID:11078175 enalapril increases expression EXP   6480464 Enalapril results in increased expression of REN mRNA CTD PMID:21423293 more ... enalapril increases expression EXP   6480464 Enalapril results in increased expression of REN mRNA CTD PMID:12434137 more ... enalapril increases expression ISO RGD:1332384 6480464 Enalapril results in increased expression of REN mRNA CTD PMID:19767874 more ... enalapril increases expression ISO RGD:1332384 6480464 Enalapril results in increased expression of REN protein CTD PMID:19536436 PMID:19767874 enalapril increases expression EXP   6480464 Enalapril results in increased expression of REN mRNA CTD PMID:12434137 more ... enalapril increases expression EXP   6480464 Enalapril results in increased expression of REN protein CTD PMID:1330361 PMID:12434137 enalapril increases secretion ISO RGD:1332384 6480464 Enalapril results in increased secretion of REN protein CTD PMID:19109587 PMID:19536436 enalapril increases expression ISO RGD:1332384 6480464 Enalapril results in increased expression of REN mRNA CTD PMID:19767874 more ... enalapril increases expression EXP   6480464 Enalapril results in increased expression of REN protein CTD PMID:12434137 PMID:1330361 enalapril increases expression EXP   6480464 Enalapril results in increased expression of REN mRNA CTD PMID:12434137 more ... enalapril multiple interactions ISO RGD:1332384 6480464 REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]; more ... CTD PMID:17846348 enalapril increases expression ISO RGD:1332384 6480464 Enalapril results in increased expression of REN mRNA CTD PMID:19536436 more ... enalapril increases expression EXP   6480464 Enalapril results in increased expression of REN mRNA CTD PMID:18796534 more ... enalapril multiple interactions ISO RGD:1332384 6480464 Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]; more ... CTD PMID:19536436 enalapril multiple interactions ISO RGD:1332384 6480464 GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]; more ... CTD PMID:19109587 enalapril increases expression ISO RGD:1332384 6480464 Enalapril results in increased expression of REN protein CTD PMID:19767874 PMID:19536436 enalapril increases secretion ISO RGD:1332384 6480464 Enalapril results in increased secretion of REN protein CTD PMID:19536436 PMID:19109587 enalapril increases expression ISO RGD:1332384 6480464 Enalapril results in increased expression of REN mRNA CTD PMID:21424707 more ... enalapril decreases activity ISO RGD:736366 6480464 Enalapril results in decreased activity of REN protein CTD PMID:18679781 enalapril multiple interactions ISO RGD:736366 6480464 Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone] CTD PMID:18679781 enalapril increases activity EXP   6480464 Enalapril results in increased activity of REN protein CTD PMID:6094050 enalapril increases expression EXP   6480464 Enalapril results in increased expression of REN mRNA; more ... CTD PMID:1330361 enalapril increases expression ISO RGD:736366 6480464 Enalapril results in increased expression of REN protein CTD PMID:2994932 enalaprilat dihydrate increases expression EXP   6480464 Enalaprilat results in increased expression of REN mRNA CTD PMID:21795644 ethanol multiple interactions EXP   6480464 Losartan inhibits the reaction [Ethanol results in increased activity of REN protein] CTD PMID:22982071 ethanol increases activity EXP   6480464 Ethanol results in increased activity of REN protein CTD PMID:22982071 fenoterol increases activity ISO RGD:736366 6480464 Fenoterol results in increased activity of REN protein CTD PMID:9209250 fenoterol increases expression ISO RGD:736366 6480464 Fenoterol results in increased expression of REN protein CTD PMID:2829953 fentanyl multiple interactions ISO RGD:736366 6480464 [Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein CTD PMID:3284271 folic acid multiple interactions ISO RGD:1332384 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of REN1 mRNA CTD PMID:20938992 furosemide multiple interactions ISO RGD:736366 6480464 Furosemide inhibits the reaction [Ethinyl Estradiol results in increased expression of REN protein] CTD PMID:11095476 furosemide increases activity EXP   6480464 Furosemide results in increased activity of REN protein CTD PMID:11135058 PMID:10604960 furosemide increases expression ISO RGD:736366 6480464 Furosemide results in increased expression of REN protein CTD PMID:3530574 PMID:4028619 furosemide multiple interactions ISO RGD:736366 6480464 Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein] CTD PMID:4028619 PMID:3530574 furosemide increases activity ISO RGD:736366 6480464 Furosemide results in increased activity of REN protein CTD PMID:11046100 more ... furosemide increases expression EXP   6480464 Furosemide results in increased expression of REN mRNA CTD PMID:8418022 PMID:11135058 furosemide increases activity ISO RGD:736366 6480464 Furosemide results in increased activity of REN protein CTD PMID:1924052 more ... furosemide increases secretion EXP   6480464 Furosemide results in increased secretion of REN protein CTD PMID:8418022 furosemide increases expression EXP   6480464 Furosemide results in increased expression of REN protein CTD PMID:7954537 furosemide increases activity EXP   6480464 Furosemide results in increased activity of REN protein CTD PMID:10604960 PMID:11135058 furosemide increases expression EXP   6480464 Furosemide results in increased expression of REN mRNA CTD PMID:11135058 PMID:8418022 furosemide multiple interactions ISO RGD:1332384 6480464 PTGER4 protein affects the reaction [Furosemide results in increased expression of REN mRNA]; more ... CTD PMID:15976003 furosemide multiple interactions ISO RGD:736366 6480464 Sulindac inhibits the reaction [Furosemide results in increased expression of REN protein] CTD PMID:4028619 furosemide increases expression ISO RGD:1332384 6480464 Furosemide results in increased expression of REN protein; more ... CTD PMID:15976003 furosemide multiple interactions ISO RGD:736366 6480464 Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein] CTD PMID:1924052 furosemide increases expression ISO RGD:736366 6480464 Furosemide results in increased expression of REN protein CTD PMID:4028619 PMID:3530574 furosemide multiple interactions ISO RGD:736366 6480464 Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein] CTD PMID:3530574 PMID:4028619 furosemide increases activity ISO RGD:736366 6480464 Furosemide results in increased activity of REN protein CTD PMID:11046100 more ... glucose increases expression EXP   6480464 Glucose results in increased expression of REN mRNA; more ... CTD PMID:19861503 glycyrrhetinate decreases activity ISO RGD:736366 6480464 Glycyrrhetinic Acid results in decreased activity of REN protein CTD PMID:20460744 glycyrrhetinic acid decreases activity ISO RGD:736366 6480464 Glycyrrhetinic Acid results in decreased activity of REN protein CTD PMID:20460744 glycyrrhizinic acid decreases activity ISO RGD:736366 6480464 Glycyrrhizic Acid results in decreased activity of REN protein CTD PMID:20460744 halothane multiple interactions ISO RGD:736366 6480464 [Halothane co-treated with Nitroprusside] results in increased activity of REN protein CTD PMID:3281763 hydralazine multiple interactions ISO RGD:736366 6480464 Alprenolol inhibits the reaction [Hydralazine results in increased expression of REN protein] CTD PMID:923630 hydralazine increases expression ISO RGD:736366 6480464 Hydralazine results in increased expression of REN protein CTD PMID:923630 PMID:2953239 hydralazine increases activity EXP   6480464 Hydralazine results in increased activity of REN protein CTD PMID:231700 PMID:2203898 hydralazine increases activity EXP   6480464 Hydralazine results in increased activity of REN protein CTD PMID:2203898 PMID:231700 hydralazine increases expression ISO RGD:736366 6480464 Hydralazine results in increased expression of REN protein CTD PMID:2953239 PMID:923630 hydralazine increases activity ISO RGD:736366 6480464 Hydralazine results in increased activity of REN protein CTD PMID:3154321 indapamide increases expression ISO RGD:736366 6480464 Indapamide results in increased expression of REN protein CTD PMID:6578003 indomethacin multiple interactions ISO RGD:736366 6480464 [Indomethacin co-treated with Amlodipine] results in decreased expression of REN protein; more ... CTD PMID:11078175 indomethacin decreases expression ISO RGD:736366 6480464 Indomethacin results in decreased expression of REN protein CTD PMID:119300 more ... indomethacin decreases expression ISO RGD:736366 6480464 Indomethacin results in decreased expression of REN protein CTD PMID:119300 more ... indomethacin decreases activity ISO RGD:736366 6480464 Indomethacin results in decreased activity of REN protein CTD PMID:3884224 more ... indomethacin decreases activity ISO RGD:736366 6480464 Indomethacin results in decreased activity of REN protein CTD PMID:7049707 more ... indomethacin decreases expression ISO RGD:736366 6480464 Indomethacin results in decreased expression of REN protein CTD PMID:6758745 more ... indomethacin decreases expression ISO RGD:736366 6480464 Indomethacin results in decreased expression of REN protein CTD PMID:6758745 more ... indomethacin decreases expression ISO RGD:736366 6480464 Indomethacin results in decreased expression of REN protein CTD PMID:3530574 more ... indomethacin decreases activity ISO RGD:736366 6480464 Indomethacin results in decreased activity of REN protein CTD PMID:929154 more ... indomethacin decreases expression ISO RGD:736366 6480464 Indomethacin results in decreased expression of REN protein CTD PMID:119300 more ... indomethacin decreases activity ISO RGD:736366 6480464 Indomethacin results in decreased activity of REN protein CTD PMID:7049707 more ... indomethacin multiple interactions ISO RGD:736366 6480464 Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein] CTD PMID:3530574 PMID:4028619 indomethacin decreases activity EXP   6480464 Indomethacin results in decreased activity of REN protein CTD PMID:439781 indomethacin multiple interactions EXP   6480464 Indomethacin inhibits the reaction [Yohimbine results in increased expression of REN protein] CTD PMID:6323192 indomethacin multiple interactions ISO RGD:736366 6480464 [Oxprenolol co-treated with Indomethacin] results in decreased activity of REN protein CTD PMID:7049707 indomethacin multiple interactions EXP   6480464 Indomethacin inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein] CTD PMID:6753910 indomethacin decreases expression ISO RGD:736366 6480464 Indomethacin results in decreased expression of REN protein CTD PMID:6758745 more ... indomethacin decreases activity ISO RGD:736366 6480464 Indomethacin results in decreased activity of REN protein CTD PMID:3884224 more ... indomethacin multiple interactions ISO RGD:736366 6480464 Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein] CTD PMID:4028619 PMID:3530574 indomethacin multiple interactions ISO RGD:736366 6480464 Indomethacin inhibits the reaction [Bumetanide results in increased activity of REN protein]; more ... CTD PMID:6756707 irbesartan increases expression ISO RGD:736366 6480464 irbesartan results in increased expression of REN protein CTD PMID:14639093 isoflurane affects activity ISO RGD:736366 6480464 Isoflurane affects the activity of REN protein CTD PMID:3281763 isoflurane multiple interactions ISO RGD:736366 6480464 [Labetalol co-treated with Isoflurane] results in increased expression of REN protein CTD PMID:1897344 isoflurane multiple interactions ISO RGD:736366 6480464 [Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein CTD PMID:3284271 isoprenaline increases activity ISO RGD:736366 6480464 Isoproterenol results in increased activity of REN protein CTD PMID:6314140 isoprenaline increases expression EXP   6480464 Isoproterenol results in increased expression of REN protein CTD PMID:9539862 PMID:11709406 isoprenaline multiple interactions EXP   6480464 Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein] CTD PMID:9539862 isoprenaline multiple interactions EXP   6480464 Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]; more ... CTD PMID:11709406 isoprenaline increases expression EXP   6480464 Isoproterenol results in increased expression of REN protein CTD PMID:11709406 PMID:9539862 isoprenaline increases secretion EXP   6480464 Isoproterenol results in increased secretion of REN protein CTD PMID:3910304 isoprenaline multiple interactions ISO RGD:736366 6480464 Propranolol inhibits the reaction [Isoproterenol results in increased expression of REN protein] CTD PMID:1653766 isoprenaline increases secretion ISO RGD:1332384 6480464 Isoproterenol results in increased secretion of REN protein CTD PMID:3515047 isoprenaline increases expression ISO RGD:1332384 6480464 Isoproterenol results in increased expression of REN mRNA CTD PMID:21424707 isoprenaline increases expression ISO RGD:736366 6480464 Isoproterenol results in increased expression of REN protein CTD PMID:1653766 ketamine increases expression ISO RGD:736366 6480464 Ketamine results in increased expression of REN protein CTD PMID:6349867 ketoprofen multiple interactions ISO RGD:736366 6480464 Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein] CTD PMID:1924052 L-methionine multiple interactions ISO RGD:1332384 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of REN1 mRNA CTD PMID:20938992 labetalol multiple interactions ISO RGD:736366 6480464 [Labetalol co-treated with Isoflurane] results in increased expression of REN protein CTD PMID:1897344 labetalol decreases activity ISO RGD:736366 6480464 Labetalol results in decreased activity of REN protein CTD PMID:2524958 more ... labetalol decreases activity ISO RGD:736366 6480464 Labetalol results in decreased activity of REN protein CTD PMID:7988622 more ... labetalol decreases activity ISO RGD:736366 6480464 Labetalol results in decreased activity of REN protein CTD PMID:7013770 more ... labetalol decreases activity ISO RGD:736366 6480464 Labetalol results in decreased activity of REN protein CTD PMID:7013770 more ... lisinopril dihydrate increases expression ISO RGD:736366 6480464 Lisinopril results in increased expression of REN protein CTD PMID:2550029 lisinopril dihydrate increases expression EXP   6480464 Lisinopril results in increased expression of REN mRNA CTD PMID:8915971 losartan multiple interactions ISO RGD:736366 6480464 Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein] CTD PMID:12569265 losartan multiple interactions EXP   6480464 Losartan inhibits the reaction [Ethanol results in increased activity of REN protein] CTD PMID:22982071 losartan increases expression EXP   6480464 Losartan results in increased expression of REN protein CTD PMID:12013499 more ... losartan increases expression EXP   6480464 Losartan results in increased expression of REN protein CTD PMID:1387008 more ... losartan increases expression EXP   6480464 Losartan results in increased expression of REN protein CTD PMID:12013499 more ... losartan increases expression EXP   6480464 Losartan results in increased expression of REN mRNA CTD PMID:9533614 PMID:9431853 losartan increases expression EXP   6480464 Losartan results in increased expression of REN protein CTD PMID:8382237 more ... losartan increases expression EXP   6480464 Losartan results in increased expression of REN protein CTD PMID:12013499 more ... losartan increases expression EXP   6480464 Losartan results in increased expression of REN mRNA CTD PMID:9431853 PMID:9533614 losartan increases activity EXP   6480464 Losartan results in increased activity of REN protein CTD PMID:9431853 losartan increases activity ISO RGD:736366 6480464 Losartan results in increased activity of REN protein CTD PMID:8403307 PMID:7965263 losartan increases expression EXP   6480464 Losartan results in increased expression of REN protein CTD PMID:8382237 more ... losartan multiple interactions EXP   6480464 Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein] CTD PMID:11709406 losartan increases expression EXP   6480464 Losartan results in increased expression of REN mRNA CTD PMID:9533614 losartan increases activity ISO RGD:736366 6480464 Losartan results in increased activity of REN protein CTD PMID:7965263 PMID:8403307 losartan increases expression ISO RGD:1332384 6480464 Losartan results in increased expression of REN protein CTD PMID:9245700 losartan multiple interactions ISO RGD:736366 6480464 [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein CTD PMID:9124547 magnesium sulfate increases activity ISO RGD:736366 6480464 Magnesium Sulfate results in increased activity of REN protein CTD PMID:1874207 metoprolol decreases expression ISO RGD:736366 6480464 Metoprolol results in decreased expression of REN protein CTD PMID:2454358 metoprolol decreases expression EXP   6480464 Metoprolol results in decreased expression of REN mRNA CTD PMID:8203557 milrinone multiple interactions ISO RGD:1332384 6480464 Milrinone inhibits the reaction [NOS1 gene mutant form results in decreased secretion of REN1 protein] CTD PMID:20651700 minoxidil affects expression ISO RGD:736366 6480464 Minoxidil affects the expression of REN protein CTD PMID:28811 minoxidil increases expression EXP   6480464 Minoxidil results in increased expression of REN protein CTD PMID:8238566 minoxidil increases activity EXP   6480464 Minoxidil results in increased activity of REN protein CTD PMID:145319 minoxidil multiple interactions ISO RGD:736366 6480464 Minoxidil binds to and results in decreased activity of REN protein CTD PMID:790007 N-acetyl-L-cysteine multiple interactions EXP   6480464 Acetylcysteine inhibits the reaction [ioxitalamic acid results in increased expression of REN protein] CTD PMID:19945959 naloxone increases activity ISO RGD:736366 6480464 Naloxone results in increased activity of REN protein CTD PMID:3157294 naproxen decreases activity ISO RGD:736366 6480464 Naproxen results in decreased activity of REN protein CTD PMID:2203262 nifedipine multiple interactions ISO RGD:736366 6480464 [Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein CTD PMID:3142437 nifedipine increases activity ISO RGD:736366 6480464 Nifedipine results in increased activity of REN protein CTD PMID:6354932 more ... nifedipine increases activity ISO RGD:736366 6480464 Nifedipine results in increased activity of REN protein CTD PMID:6354932 more ... nifedipine increases activity ISO RGD:736366 6480464 Nifedipine results in increased activity of REN protein CTD PMID:3326920 more ... nifedipine increases expression ISO RGD:736366 6480464 Nifedipine results in increased expression of REN protein CTD PMID:3313686 nifedipine increases activity ISO RGD:736366 6480464 Nifedipine results in increased activity of REN protein CTD PMID:6184561 more ... nifedipine multiple interactions ISO RGD:736366 6480464 Angiotensin-Converting Enzyme Inhibitors promotes the reaction [Nifedipine results in increased activity of REN protein]; more ... CTD PMID:3326920 nitric oxide multiple interactions EXP   6480464 nebivolol inhibits the reaction [Nitric Oxide deficiency results in increased expression of REN protein] CTD PMID:12806161 nitric oxide increases expression EXP   6480464 Nitric Oxide deficiency results in increased expression of REN protein CTD PMID:10679504 PMID:15123544 nitric oxide increases expression EXP   6480464 Nitric Oxide deficiency results in increased expression of REN protein CTD PMID:15123544 PMID:10679504 nitric oxide multiple interactions EXP   6480464 [Nitric Oxide deficiency co-treated with Sodium Chloride, Dietary] results in increased expression of REN protein CTD PMID:7541960 nitroglycerin increases activity ISO RGD:736366 6480464 Nitroglycerin results in increased activity of REN protein CTD PMID:9527094 nitroprusside multiple interactions ISO RGD:736366 6480464 esmolol inhibits the reaction [Nitroprusside results in increased activity of REN protein] CTD PMID:2569849 nitroprusside increases activity ISO RGD:736366 6480464 Nitroprusside results in increased activity of REN protein CTD PMID:1867428 more ... nitroprusside increases activity ISO RGD:736366 6480464 Nitroprusside results in increased activity of REN protein CTD PMID:6434220 more ... nitroprusside increases activity ISO RGD:736366 6480464 Nitroprusside results in increased activity of REN protein CTD PMID:3152422 more ... nitroprusside increases activity ISO RGD:736366 6480464 Nitroprusside results in increased activity of REN protein CTD PMID:7351115 more ... nitroprusside increases activity ISO RGD:736366 6480464 Nitroprusside results in increased activity of REN protein CTD PMID:1867428 more ... nitroprusside multiple interactions ISO RGD:736366 6480464 Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein] CTD PMID:453612 PMID:7020487 nitroprusside increases activity ISO RGD:736366 6480464 Nitroprusside results in increased activity of REN protein CTD PMID:7351115 more ... nitroprusside multiple interactions EXP   6480464 Nitroprusside affects the reaction [Sodium affects the activity of REN protein] CTD PMID:7009830 nitroprusside increases activity ISO RGD:736366 6480464 Nitroprusside results in increased activity of REN protein CTD PMID:2413294 more ... nitroprusside multiple interactions ISO RGD:736366 6480464 Propranolol inhibits the reaction [Nitroprusside results in increased activity of REN protein] CTD PMID:6434220 nitroprusside multiple interactions ISO RGD:736366 6480464 Propranolol affects the reaction [Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]] CTD PMID:7020487 nitroprusside multiple interactions ISO RGD:736366 6480464 Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein] CTD PMID:7020487 PMID:453612 nitroprusside multiple interactions ISO RGD:736366 6480464 [Halothane co-treated with Nitroprusside] results in increased activity of REN protein CTD PMID:3281763 nitroprusside multiple interactions ISO RGD:736366 6480464 bunitrolol inhibits the reaction [Nitroprusside results in increased activity of REN protein] CTD PMID:6113146 paracetamol multiple interactions ISO RGD:1332384 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of REN1 mRNA; more ... CTD PMID:17585979 paracetamol increases expression ISO RGD:736366 6480464 Acetaminophen results in increased expression of REN protein CTD PMID:455818 paracetamol multiple interactions ISO RGD:736366 6480464 ALB protein inhibits the reaction [Acetaminophen results in increased activity of REN protein] CTD PMID:1825077 paracetamol increases activity ISO RGD:736366 6480464 Acetaminophen results in increased activity of REN protein CTD PMID:1825077 paricalcitol multiple interactions ISO RGD:1332384 6480464 [Phosphorus co-treated with paricalcitol] results in decreased expression of REN1 mRNA CTD PMID:17715259 pentobarbital increases activity EXP   6480464 Pentobarbital results in increased activity of REN protein CTD PMID:3512818 perindopril increases activity ISO RGD:736366 6480464 Perindopril results in increased activity of REN protein CTD PMID:2605800 PMID:2549899 perindopril increases activity ISO RGD:736366 6480464 Perindopril results in increased activity of REN protein CTD PMID:2549899 PMID:2605800 perindopril increases expression EXP   6480464 Perindopril results in increased expression of REN protein CTD PMID:9383173 phenylephrine decreases activity ISO RGD:736366 6480464 Phenylephrine results in decreased activity of REN protein CTD PMID:2847676 phenylephrine affects response to substance ISO RGD:1332384 6480464 REN1 protein affects the susceptibility to Phenylephrine CTD PMID:17679040 phosphorus atom multiple interactions ISO RGD:1332384 6480464 [Phosphorus co-treated with paricalcitol] results in decreased expression of REN1 mRNA CTD PMID:17715259 phosphorus(.) multiple interactions ISO RGD:1332384 6480464 [Phosphorus co-treated with paricalcitol] results in decreased expression of REN1 mRNA CTD PMID:17715259 pindolol multiple interactions ISO RGD:736366 6480464 Pindolol inhibits the reaction [REN protein results in increased cleavage of AGT protein] CTD PMID:7104148 pindolol decreases expression ISO RGD:736366 6480464 Pindolol results in decreased expression of REN protein CTD PMID:973972 pindolol decreases activity ISO RGD:736366 6480464 Pindolol results in decreased activity of REN protein CTD PMID:791319 pirinixic acid decreases expression ISO RGD:1332384 6480464 pirinixic acid results in decreased expression of REN1 mRNA CTD PMID:20059764 pirinixic acid multiple interactions ISO RGD:1332384 6480464 PPARA protein promotes the reaction [pirinixic acid results in decreased expression of REN1 mRNA] CTD PMID:20059764 practolol decreases activity EXP   6480464 Practolol results in decreased activity of REN protein CTD PMID:6110712 prazosin decreases activity ISO RGD:736366 6480464 Prazosin results in decreased activity of REN protein CTD PMID:7023672 prazosin increases activity ISO RGD:736366 6480464 Prazosin results in increased activity of REN protein CTD PMID:6173514 more ... prazosin increases activity ISO RGD:736366 6480464 Prazosin results in increased activity of REN protein CTD PMID:7023672 more ... prazosin increases activity ISO RGD:736366 6480464 Prazosin results in increased activity of REN protein CTD PMID:6258839 more ... prazosin multiple interactions EXP   6480464 Propranolol inhibits the reaction [Prazosin results in increased transport of REN protein] CTD PMID:3539430 prazosin increases transport EXP   6480464 Prazosin results in increased transport of REN protein CTD PMID:3539430 prazosin increases activity ISO RGD:736366 6480464 Prazosin results in increased activity of REN protein CTD PMID:6173514 more ... probenecid multiple interactions ISO RGD:736366 6480464 Probenecid inhibits the reaction [Bumetanide results in increased secretion of REN protein] CTD PMID:7040495 propofol multiple interactions ISO RGD:736366 6480464 [Propofol co-treated with desflurane] results in increased expression of REN protein CTD PMID:8017643 propranolol multiple interactions ISO RGD:736366 6480464 Propranolol affects the reaction [Anesthetics, Combined results in increased activity of REN protein]; more ... CTD PMID:7020487 propranolol decreases activity ISO RGD:736366 6480464 Propranolol results in decreased activity of REN protein CTD PMID:1103606 more ... propranolol decreases activity ISO RGD:736366 6480464 Propranolol results in decreased activity of REN protein CTD PMID:791319 more ... propranolol decreases activity ISO RGD:736366 6480464 Propranolol results in decreased activity of REN protein CTD PMID:637424 more ... propranolol decreases activity ISO RGD:736366 6480464 Propranolol results in decreased activity of REN protein CTD PMID:791319 more ... propranolol decreases activity EXP   6480464 Propranolol results in decreased activity of REN protein CTD PMID:6110712 PMID:145319 propranolol decreases activity ISO RGD:736366 6480464 Propranolol results in decreased activity of REN protein CTD PMID:637424 more ... propranolol decreases expression ISO RGD:736366 6480464 Propranolol results in decreased expression of REN protein CTD PMID:653302 PMID:200433 propranolol decreases activity ISO RGD:736366 6480464 Propranolol results in decreased activity of REN protein CTD PMID:1103606 more ... propranolol decreases activity EXP   6480464 Propranolol results in decreased activity of REN protein CTD PMID:145319 PMID:6110712 propranolol multiple interactions EXP   6480464 Propranolol inhibits the reaction [Prazosin results in increased transport of REN protein] CTD PMID:3539430 propranolol multiple interactions EXP   6480464 Propranolol inhibits the reaction [Yohimbine results in increased expression of REN protein] CTD PMID:6323192 propranolol multiple interactions EXP   6480464 Propranolol inhibits the reaction [ioxitalamic acid results in increased expression of REN protein] CTD PMID:19945959 propranolol decreases expression ISO RGD:736366 6480464 Propranolol results in decreased expression of REN protein CTD PMID:200433 PMID:653302 propranolol decreases activity ISO RGD:736366 6480464 Propranolol results in decreased activity of REN protein CTD PMID:791319 more ... propranolol multiple interactions ISO RGD:736366 6480464 Propranolol inhibits the reaction [REN protein results in increased cleavage of AGT protein] CTD PMID:7104148 propranolol multiple interactions ISO RGD:736366 6480464 Propranolol inhibits the reaction [Nitroprusside results in increased activity of REN protein] CTD PMID:6434220 propranolol multiple interactions ISO RGD:736366 6480464 Propranolol inhibits the reaction [Isoproterenol results in increased expression of REN protein] CTD PMID:1653766 prostaglandin E1 increases expression ISO RGD:736366 6480464 Alprostadil results in increased expression of REN protein CTD PMID:9195357 quinapril hydrochloride multiple interactions EXP   6480464 quinapril promotes the reaction [Isoproterenol results in increased expression of REN protein] CTD PMID:11709406 quinapril hydrochloride increases expression EXP   6480464 quinapril results in increased expression of REN protein CTD PMID:10334802 ramipril increases activity ISO RGD:736366 6480464 Ramipril results in increased activity of REN protein CTD PMID:1327051 ramipril multiple interactions EXP   6480464 Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]; more ... CTD PMID:11832429 ramipril increases expression EXP   6480464 Ramipril results in increased expression of REN protein CTD PMID:9179393 ramipril multiple interactions EXP   6480464 Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein] CTD PMID:9539862 ramipril increases expression ISO RGD:1332384 6480464 Ramipril results in increased expression of REN mRNA CTD PMID:14504926 ranitidine affects activity ISO RGD:736366 6480464 Ranitidine affects the activity of REN protein CTD PMID:1972605 riddelliine increases expression EXP   6480464 riddelliine results in increased expression of REN mRNA CTD PMID:18047727 sildenafil increases activity ISO RGD:736366 6480464 sildenafil results in increased activity of REN protein CTD PMID:15613622 sirolimus increases expression EXP   6480464 Sirolimus results in increased expression of REN mRNA CTD PMID:21865292 sodium atom increases activity ISO RGD:736366 6480464 Sodium deficiency results in increased activity of REN protein CTD PMID:11299228 sodium atom decreases secretion ISO RGD:1332384 6480464 Sodium results in decreased secretion of REN protein CTD PMID:19536436 sodium atom decreases expression ISO RGD:1332384 6480464 Sodium results in decreased expression of REN mRNA; more ... CTD PMID:19536436 sodium atom multiple interactions ISO RGD:1332384 6480464 Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]; more ... CTD PMID:19536436 sodium atom increases expression ISO RGD:1332384 6480464 Sodium deficiency results in increased expression of REN protein; more ... CTD PMID:19767874 sodium atom affects expression EXP   6480464 Sodium affects the expression of REN mRNA CTD PMID:12424424 sodium atom affects activity EXP   6480464 Sodium affects the activity of REN protein CTD PMID:7009830 sodium atom multiple interactions EXP   6480464 Nitroprusside affects the reaction [Sodium affects the activity of REN protein] CTD PMID:7009830 sodium atom multiple interactions ISO RGD:736366 6480464 Sodium affects the reaction [Hydrochlorothiazide results in increased activity of REN protein] CTD PMID:1930859 sodium chloride multiple interactions EXP   6480464 [Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of REN protein CTD PMID:11039 sodium chloride multiple interactions ISO RGD:1332384 6480464 REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]; more ... CTD PMID:17846348 sodium chloride increases activity EXP   6480464 Sodium Chloride deficiency results in increased activity of REN protein CTD PMID:11832429 sodium chloride increases expression EXP   6480464 Sodium Chloride deficiency results in increased expression of REN mRNA CTD PMID:11832429 sodium chloride multiple interactions EXP   6480464 Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]; more ... CTD PMID:11832429 sodium chloride multiple interactions ISO RGD:1332384 6480464 GJA5 affects the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA] CTD PMID:19474190 sodium chloride increases expression ISO RGD:1332384 6480464 Sodium Chloride deficiency results in increased expression of REN mRNA CTD PMID:19474190 sodium chloride multiple interactions EXP   6480464 Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein] CTD PMID:235222 sodium chloride increases expression EXP   6480464 Sodium Chloride results in increased expression of REN1 protein CTD PMID:15134804 soyasaponin I decreases activity ISO RGD:736366 6480464 soyasaponin I results in decreased activity of REN protein CTD PMID:19060406 PMID:20460744 spironolactone multiple interactions ISO RGD:736366 6480464 [Clonidine co-treated with Spironolactone] results in decreased expression of REN protein CTD PMID:12014310 spironolactone increases expression ISO RGD:736366 6480464 Spironolactone results in increased expression of REN protein CTD PMID:20016520 PMID:9595286 spironolactone decreases response to substance ISO RGD:736366 6480464 REN protein results in decreased susceptibility to Spironolactone CTD PMID:6998872 spironolactone increases expression ISO RGD:736366 6480464 Spironolactone results in increased expression of REN protein CTD PMID:9595286 PMID:20016520 sulindac multiple interactions ISO RGD:736366 6480464 Sulindac inhibits the reaction [Furosemide results in increased expression of REN protein] CTD PMID:4028619 sulindac decreases activity ISO RGD:736366 6480464 Sulindac results in decreased activity of REN protein CTD PMID:3884224 PMID:2203262 sulindac decreases activity ISO RGD:736366 6480464 Sulindac results in decreased activity of REN protein CTD PMID:2203262 PMID:3884224 tacrolimus hydrate multiple interactions EXP   6480464 nilvadipine inhibits the reaction [Tacrolimus results in increased expression of REN protein] CTD PMID:7533848 tacrolimus hydrate increases expression EXP   6480464 Tacrolimus results in increased expression of REN protein CTD PMID:7532090 PMID:7533848 tacrolimus hydrate increases expression EXP   6480464 Tacrolimus results in increased expression of REN mRNA CTD PMID:21865292 PMID:12469222 tacrolimus hydrate increases expression EXP   6480464 Tacrolimus results in increased expression of REN mRNA CTD PMID:12469222 PMID:21865292 tacrolimus hydrate increases expression EXP   6480464 Tacrolimus results in increased expression of REN protein CTD PMID:7533848 PMID:7532090 tacrolimus hydrate increases expression EXP   6480464 Tacrolimus results in increased expression of REN mRNA CTD PMID:12469222 tacrolimus hydrate decreases activity EXP   6480464 Tacrolimus results in decreased activity of REN protein CTD PMID:7509514 telmisartan increases expression EXP   6480464 telmisartan results in increased expression of REN mRNA; more ... CTD PMID:9533614 terbutaline multiple interactions ISO RGD:736366 6480464 Dactinomycin inhibits the reaction [Terbutaline results in increased secretion of REN protein]; more ... CTD PMID:9203624 terbutaline increases expression ISO RGD:736366 6480464 Terbutaline results in increased expression of REN mRNA CTD PMID:9203624 terbutaline increases secretion ISO RGD:736366 6480464 Terbutaline results in increased secretion of REN protein CTD PMID:9203624 PMID:9256163 terbutaline multiple interactions ISO RGD:736366 6480464 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone promotes the reaction [Terbutaline results in increased secretion of REN protein]; more ... CTD PMID:9256163 tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of REN1 mRNA CTD PMID:16644059 tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of REN1 protein CTD PMID:16713642 theophylline affects expression ISO RGD:736366 6480464 Theophylline affects the expression of REN protein CTD PMID:7743391 valsartan increases expression EXP   6480464 valsartan results in increased expression of REN protein CTD PMID:8505092 valsartan increases activity EXP   6480464 valsartan results in increased activity of REN protein CTD PMID:11501062 valsartan multiple interactions EXP   6480464 [benazepril co-treated with valsartan] results in increased activity of REN protein CTD PMID:11501062 valsartan multiple interactions ISO RGD:736366 6480464 [benazepril co-treated with valsartan] results in increased activity of REN protein CTD PMID:10836730 yohimbine multiple interactions EXP   6480464 Chlorisondamine inhibits the reaction [Yohimbine results in increased expression of REN protein]; more ... CTD PMID:6323192 yohimbine increases expression EXP   6480464 Yohimbine results in increased expression of REN protein CTD PMID:6323192 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) angiotensin maturation   IDA   5132599   RGD   angiotensin maturation   ISO RGD:736366 1624291 PMID:12045255 RGD PMID:12045255 angiotensin maturation   ISO RGD:1332384 1624291 MGI:MGI:2136642 RGD MGI:MGI:1351364 PMID:10617578 beta-amyloid metabolic process   IEP   6892653   RGD   cell maturation   ISO RGD:1332384 1624291 MGI:MGI:2136642 RGD MGI:MGI:1351364 PMID:10617578 cell maturation   IEA Ensembl:ENSMUSP00000092135 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 cellular response to drug   IEP   6892652 secretagogue C4880 RGD   drinking behavior   ISO RGD:1332384 1624291 MGI:MGI:2136642 RGD MGI:MGI:1351364 PMID:10617578 drinking behavior   IEA Ensembl:ENSMUSP00000092135 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 establishment of blood-nerve barrier NOT ISO RGD:1332384 1624291 MGI:MGI:2136642 RGD MGI:MGI:1351364 PMID:10617578 hormone-mediated signaling pathway   ISO RGD:1332384 1624291 MGI:MGI:3027605|PMID:14583438 RGD MGI:MGI:3027605 PMID:14583438 hormone-mediated signaling pathway   IEA Ensembl:ENSMUSP00000092135 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 kidney development   ISO RGD:736366 1624291 PMID:16116425 RGD PMID:16116425 male gonad development   IEA Ensembl:ENSMUSP00000092135 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 mesonephros development   IEA Ensembl:ENSMUSP00000092135 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 proteolysis   ISO RGD:736366 1624291 PMID:12045255 RGD PMID:12045255 proteolysis   IEA Ensembl:ENSP00000272190 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of blood pressure   TAS   70564   RGD   regulation of blood pressure   IMP   61046   RGD   regulation of blood volume by renin-angiotensin   ISO RGD:1332384 1624291 MGI:MGI:2136642 RGD MGI:MGI:1351364 PMID:10617578 regulation of MAPK cascade   ISO RGD:736366 1624291 PMID:12045255 RGD PMID:12045255 regulation of MAPK cascade   IEA Ensembl:ENSP00000272190 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 renin-angiotensin regulation of aldosterone production   ISO RGD:1332384 1624291 MGI:MGI:3848759|PMID:19293336 RGD MGI:MGI:3848759 PMID:19293336 renin-angiotensin regulation of aldosterone production   IEA Ensembl:ENSMUSP00000092135 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to cAMP   IDA   2311696   RGD   response to cGMP   IDA   2311696   RGD   response to drug   IDA   2311696 isoproterenol RGD   response to lipopolysaccharide   IEP   6892689   RGD   response to organic substance   ISO RGD:1332384 1624291 MGI:MGI:3848759|PMID:19293336 RGD MGI:MGI:3848759 PMID:19293336 response to stress   IDA   2311699   RGD   Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytoplasmic part   IDA   1581651   RGD   extracellular space   IDA   2311698   RGD   extracellular space   ISO RGD:736366 1624291 PMID:12045255 RGD PMID:12045255 extracellular space   ISO RGD:1332384 1624291 MGI:MGI:3848759|PMID:19293336 RGD MGI:MGI:3848759 PMID:19293336 extracellular space   ISO RGD:1332384 1624291 MGI:MGI:1336863|PMID:10318840 RGD MGI:MGI:1336863 PMID:10318840 intracellular   ISO RGD:1332384 1624291 MGI:MGI:3848759|PMID:19293336 RGD MGI:MGI:3848759 PMID:19293336 membrane   IEA UniProtKB-SubCell:SL-0162 1600115 GO_REF:0000039 UniProtKB GO_REF:0000039 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) aspartic-type endopeptidase activity   ISO RGD:736366 1624291 PMID:12045255 RGD PMID:12045255 aspartic-type endopeptidase activity   ISO RGD:736366 1624291 Reactome:REACT_147720 RGD Reactome:REACT_147720 aspartic-type endopeptidase activity   IEA Ensembl:ENSP00000272190 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 endopeptidase activity   IDA   2311700   RGD   endopeptidase activity   ISO RGD:1332384 1624291 MGI:MGI:3848759|PMID:19293336 RGD MGI:MGI:3848759 PMID:19293336 insulin-like growth factor receptor binding   IDA   1581738   RGD   peptidase activity   ISO RGD:736366 1624291 PMID:12045255 RGD PMID:12045255 receptor binding   IPI RGD:1561269 5132599   RGD   receptor binding   ISO RGD:736366 1624291 UniProtKB:O75787 RGD PMID:12045255 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) renin-angiotensin cascade pathway   IDA   1581738   RGD   renin-angiotensin cascade pathway   IEA RGD:3554 6907045   KEGG rno:04614 renin-angiotensin cascade pathway   ISS RGD:736366 1581742   RGD   renin-angiotensin cascade pathway   IDA   1581651   RGD   renin-angiotensin cascade pathway   TAS   1581739   RGD   External Database Links KEGG Pathway Renin-angiotensin system Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) increased systemic arterial blood pressure   IAGP   61046   RGD   Disease Annotations Atrial Fibrillation  (ISS) Cardiomegaly  (ISS) Diabetic Nephropathies  (IED) Fatigue Syndrome, Chronic  (ISS) Hypertension  (IED,ISS) Hypertension, Portal  (ISS) Hypertension, Renovascular  (ISS) Hypertrophy, Left Ventricular  (IEP) HYPERURICEMIC NEPHROPATHY, FAMILIAL JUVENILE, 2  (ISS) Kidney Diseases  (ISS) Liver Cirrhosis, Biliary  (IEP) Myocardial Infarction  (ISS) Obesity  (ISS) RENAL TUBULAR DYSGENESIS  (ISS) Gene-Chemical Interaction Annotations (R)-adrenaline  (ISO) 11-deoxycorticosterone  (EXP) 17alpha-ethynylestradiol  (ISO) 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]  (EXP) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) 2,4-dinitrotoluene  (EXP) 2,6-dinitrotoluene  (EXP) 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP) 6alpha-methylprednisolone  (EXP) acebutolol  (EXP,ISO) acetylsalicylic acid  (ISO) actinomycin D  (ISO) adenosine  (EXP) albuterol  (ISO) aldosterone  (ISO) all-trans-retinoic acid  (ISO) alpha-methyl-L-dopa  (EXP) alprenolol  (ISO) aluminium phosphide  (ISO) amlodipine  (ISO) ammonium chloride  (EXP) atenolol  (EXP,ISO) benazepril  (EXP,ISO) bendroflumethiazide  (ISO) bis(2-ethylhexyl) phthalate  (EXP,ISO) bucladesine  (ISO) bumetanide  (ISO) caffeine  (EXP,ISO) calcitriol  (ISO) calcium atom  (EXP) calcium(0)  (EXP) candesartan  (EXP,ISO) carvedilol  (ISO) celecoxib  (EXP) CGS-21680  (EXP) chlorthalidone  (ISO) choline  (ISO) cis-ketoconazole  (ISO) clofibrate  (ISO) clonidine  (ISO) clonidine (amino form)  (ISO) clonidine (imino form)  (ISO) cortisol  (ISO) cycloheximide  (ISO) cyclosporin A  (EXP,ISO) D-glucose  (EXP) desflurane  (ISO) dexamethasone  (EXP,ISO) diazoxide  (EXP,ISO) diethylstilbestrol  (ISO) diltiazem  (ISO) dobutamine  (ISO) doxazosin  (ISO) doxorubicin  (ISO) enalapril  (EXP,ISO) enalaprilat dihydrate  (EXP) ethanol  (EXP) fenoterol  (ISO) fentanyl  (ISO) folic acid  (ISO) furosemide  (EXP,ISO) glucose  (EXP) glycyrrhetinate  (ISO) glycyrrhetinic acid  (ISO) glycyrrhizinic acid  (ISO) halothane  (ISO) hydralazine  (EXP,ISO) indapamide  (ISO) indomethacin  (EXP,ISO) irbesartan  (ISO) isoflurane  (ISO) isoprenaline  (EXP,ISO) ketamine  (ISO) ketoprofen  (ISO) L-methionine  (ISO) labetalol  (ISO) lisinopril dihydrate  (EXP,ISO) losartan  (EXP,ISO) magnesium sulfate  (ISO) metoprolol  (EXP,ISO) milrinone  (ISO) minoxidil  (EXP,ISO) N-acetyl-L-cysteine  (EXP) naloxone  (ISO) naproxen  (ISO) nifedipine  (ISO) nitric oxide  (EXP) nitroglycerin  (ISO) nitroprusside  (EXP,ISO) paracetamol  (ISO) paricalcitol  (ISO) pentobarbital  (EXP) perindopril  (EXP,ISO) phenylephrine  (ISO) phosphorus atom  (ISO) phosphorus(.)  (ISO) pindolol  (ISO) pirinixic acid  (ISO) practolol  (EXP) prazosin  (EXP,ISO) probenecid  (ISO) propofol  (ISO) propranolol  (EXP,ISO) prostaglandin E1  (ISO) quinapril hydrochloride  (EXP) ramipril  (EXP,ISO) ranitidine  (ISO) riddelliine  (EXP) sildenafil  (ISO) sirolimus  (EXP) sodium atom  (EXP,ISO) sodium chloride  (EXP,ISO) soyasaponin I  (ISO) spironolactone  (ISO) sulindac  (ISO) tacrolimus hydrate  (EXP) telmisartan  (EXP) terbutaline  (ISO) tetrachloromethane  (EXP) theophylline  (ISO) valsartan  (EXP,ISO) yohimbine  (EXP) Gene Ontology Annotations Biological Process angiotensin maturation  (IDA,ISO) beta-amyloid metabolic process  (IEP) cell maturation  (IEA,ISO) cellular response to drug  (IEP) drinking behavior  (IEA,ISO) establishment of blood-nerve barrier  (ISO) hormone-mediated signaling pathway  (IEA,ISO) kidney development  (ISO) male gonad development  (IEA) mesonephros development  (IEA) proteolysis  (IEA,ISO) regulation of blood pressure  (IMP,TAS) regulation of blood volume by renin-angiotensin  (ISO) regulation of MAPK cascade  (IEA,ISO) renin-angiotensin regulation of aldosterone production  (IEA,ISO) response to cAMP  (IDA) response to cGMP  (IDA) response to drug  (IDA) response to lipopolysaccharide  (IEP) response to organic substance  (ISO) response to stress  (IDA) Cellular Component cytoplasmic part  (IDA) extracellular space  (IDA,ISO) intracellular  (ISO) membrane  (IEA) Molecular Function aspartic-type endopeptidase activity  (IEA,ISO) endopeptidase activity  (IDA,ISO) insulin-like growth factor receptor binding  (IDA) peptidase activity  (ISO) receptor binding  (IPI,ISO) Molecular Pathway Annotations renin-angiotensin cascade pathway  (IDA,IEA,ISS,TAS) External Database Links KEGG Pathway Renin-angiotensin system Phenotype Annotations increased systemic arterial blood pressure  (IAGP) References - curated 1. Ahmad U, etal., Hypertens Res. 2005 Apr;28(4):339-44. 2. Alderman MH, etal., N Engl J Med. 1991 Apr 18;324(16):1098-104. 3. Azibani F, etal., Ann Cardiol Angeiol (Paris). 2012 May 25. 4. Baggio B, etal., Ital J Biochem. 1975 May-Aug;24(3-4):199-206. 5. Burnham CE, etal., Proc Natl Acad Sci U S A 1987 Aug;84(16):5605-9. 6. Chao J, etal., Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2264-70. Epub 2011 Sep 30. 7. Chen JG, etal., Surg Endosc. 2012 May 31. 8. Chen SD, etal., Neurochem Int. 2012 May 17;61(3):369-377. 9. Clausmeyer S, etal., Circ Res 1999 Feb 19;84(3):337-44. 10. Dubay C, etal., Nat Genet 1993 Apr;3(4):354-7 11. Fukamizu A, etal., J Mol Biol 1988 May 20;201(2):443-50. 12. Gambaryan S, etal., Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):9003-8. 13. GOA data from the GO Consortium 14. Gonzalez AA, etal., Hypertension. 2011 Apr;57(4):859-64. Epub 2011 Feb 14. 15. Gribouval O, etal., Nat Genet. 2005 Sep;37(9):964-8. Epub 2005 Aug 14. 16. Guagliardo NA, etal., Hypertension. 2012 May;59(5):999-1005. Epub 2012 Apr 9. 17. Hao XQ, etal., Exp Toxicol Pathol. 2012 Feb 17. 18. Harris EL, etal., J Hypertens 1995 Apr;13(4):397-404. 19. Ichihara A, etal., J Clin Invest. 2004 Oct;114(8):1128-35. 20. Jindra A Jr and Kvetnansky R, J Biol Chem. 1982 Jun 10;257(11):5997-9. 21. Kammerl MC, etal., Am J Physiol Regul Integr Comp Physiol 2002 Jun;282(6):R1613-7. 22. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 23. Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32. 24. Li Y, etal., Int J Cardiol. 2011 Sep 10. 25. MGD data from the GO Consortium 26. Morris BJ and Johnston CI, Endocrinology. 1976 Jun;98(6):1466-74. 27. NCBI rat LocusLink and RefSeq merged data July 26, 2002 28. Nguyen G Kidney Int. 2006 May;69(9):1503-6. 29. Okamoto LE, etal., Clin Sci (Lond). 2012 Feb;122(4):183-92. doi: 10.1042/CS20110200. 30. Paliege A, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R694-700. 31. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 32. RGD automated data pipeline 33. RGD automated import pipeline for gene-chemical interactions 34. RGD Automated Pipelines 35. Richer C, etal., Clin Exp Pharmacol Physiol 2001 Dec;28(12):997-1001. 36. Saris JJ, etal., Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1706-15. 37. Shah N, etal., J Hepatol. 2012 May;56(5):1047-53. Epub 2012 Jan 17. 38. St Lezin EM, etal., J Clin Invest. 1996 Jan 15;97(2):522-7. 39. St. Lezin EM, etal., J Clin Invest 1996 Jan 15;97(2):522-7 40. Tada M, etal., Nucleic Acids Res 1988 Apr 25;16(8):3576. 41. Takatsu M, etal., J Hypertens. 2012 Jul 12. 42. Tronik D, etal., Gene 1988 Sep 15;69(1):71-80. 43. Voigt J, etal., Eur J Biochem. 1982 Feb;122(1):183-91. 44. Warner GM, etal., Am J Physiol Renal Physiol. 2012 Jun;302(11):F1455-64. Epub 2012 Feb 29. 45. Wilkinson-Berka JL, etal., Mol Cell Endocrinol. 2002 Aug 30;194(1-2):201-9. 46. Xiang W, etal., Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E125-32. Epub 2004 Sep 14. 47. Yeung RS, etal., Mamm Genome 1993;4(10):585-8. 48. Zhang L, etal., World J Gastroenterol. 2003 Jul;9(7):1584-8. References - uncurated PubMed 10807585   11702851   12469222   12477932   12511427   12560203   15342908   15489334   15792957   15870381   17440033   17670863   18198281   18202178   18413493   18426992   18509102   18653711   18671756   18782187   19050177   19139376   19171793   19261739   19841286   19861503   20683339   20852041   21242461   21331057   21483231   21484732   21521778   21752621   21865264   22020141   23460292   8490598   9933256 RGD Disease Portals Ren has been annotated in the following RGD Disease Portals. Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Cardiovascular Phenotypes Biological Process Diabetes Diseases Diabetes Pathways Diabetes Phenotypes Immune and Inflammatory Pathways Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Obesity Phenotypes Respiratory Pathways Genomics Candidate Gene Status Ren is a candidate Gene for Bp80 Ren is a candidate Gene for Bp328 Comparative Map Data Ren   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 13 q13   NCBI RGSC Genome Assembly v5.0 13 55,555,583 - 55,566,812 - NCBI RGSC Genome Assembly v3.4 13 46,262,936 - 46,275,213 + NCBI Rat Celera Assembly 13 45,129,122 - 45,139,889 + NCBI Genome Assembly 3.1 13 46,277,000 - 46,288,249 + NCBI RH 3.4 13 170.9   RGD REN   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 210,661,671 - 210,673,192 - NCBI Human Genome Assembly HuRef 1 175,289,120 - 175,300,481 - NCBI Human Genome Assembly GRCh37 1 204,123,944 - 204,135,465 - NCBI Human Genome Assembly Build 36 1 202,390,571 - 202,402,088 - NCBI Human Cytogenetic Map 1 q32   NCBI Human Genome Assembly 1 200,855,604 - 200,867,122   NCBI Ren1   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 1 133,350,674 - 133,360,320 + NCBI Mouse cM Map 1 57.91   NCBI Mouse Celera Assembly 1 135,963,151 - 135,972,797 + NCBI Mouse Genome Assembly Build 37 1 135,247,251 - 135,256,894 + NCBI Mouse Genome Assembly Build 36.1 1 135,247,251 - 135,256,894 + NCBI Mouse Cytogenetic Map 1 E4   NCBI Position Markers D13Uwm1   Map Chr Position Strand Source Rat Cytogenetic Map 13 q13   UniSTS Genome Assembly 3.1 13 46,283,977 - 46,284,161   RGD RH 3.4 13 173.5   UniSTS D13Wox5   Map Chr Position Strand Source RGSC Genome Assembly v5.0 13 55,560,677 - 55,560,862   NCBI RGSC Genome Assembly v3.4 13 46,269,934 - 46,270,118   RGD Genome Assembly 3.1 13 46,283,977 - 46,284,161   RGD RH 3.4 13 173.5   RGD RH 2.0 13 376.9   RGD D13Arb7   Map Chr Position Strand Source Rat Cytogenetic Map 13 q13   UniSTS RGSC Genome Assembly v5.0 13 55,560,664 - 55,560,980   UniSTS RGSC Genome Assembly v3.4 13 46,269,816 - 46,270,132   UniSTS RGSC Genome Assembly v3.4 13 46,269,815 - 46,270,132   RGD Rat Celera Assembly 13 45,134,496 - 45,134,808   UniSTS Genome Assembly 3.1 13 46,283,858 - 46,284,175   RGD RH 3.4 13 182.9   RGD RH 3.4 13 182.9   UniSTS SHRSP x BN 13 14.7498   UniSTS SHRSP x BN 13 14.7498   RGD RH94507   Map Chr Position Strand Source Rat Cytogenetic Map 13 q13   UniSTS RGSC Genome Assembly v5.0 13 55,566,990 - 55,567,179   UniSTS RGSC Genome Assembly v3.4 13 46,262,569 - 46,262,758   UniSTS Rat Celera Assembly 13 45,128,755 - 45,128,944   UniSTS RH 3.4 13 170.9   UniSTS RH138392   Map Chr Position Strand Source Rat Cytogenetic Map 13 q13   UniSTS RGSC Genome Assembly v5.0 13 55,555,657 - 55,555,832   UniSTS RGSC Genome Assembly v3.4 13 46,274,964 - 46,275,139   UniSTS Rat Celera Assembly 13 45,139,640 - 45,139,815   UniSTS RH 3.4 13 181.6   UniSTS QTLs in Region (RGSC Genome Assembly v3.4) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1300163 Cardf1 Cardiac cell morphology QTL 1 4.18 Cardiac function salt-loaded aortic lesions 13 1265159 46912163 Rat 2302275 Gluco37 Glucose level QTL 37 3.8 Glucose level 13 1265159 47698301 Rat 1331784 Bp222 Blood pressure QTL 222 2.944 Blood pressure mean arterial 13 7538626 55033994 Rat 7207885 Glom27 Glomerulus QTL 27 3.9 Renal pathology glomerulus inflammation 13 10556042 106075835 Rat 2317040 Aia21 Adjuvant induced arthritis QTL 21 2.75 Joint/bone inflammation adjuvant induced 13 10688543 55688543 Rat 2317046 Aia8 Adjuvant induced arthritis QTL 8 3.9700000286102295 Joint/bone inflammation adjuvant induced 13 10688543 55688543 Rat 631645 Bp121 Blood pressure QTL 121 3.3 Blood pressure systolic 13 15989872 60989872 Rat 61391 Bp5 Blood pressure QTL 5 5.6 Blood pressure diastolic 13 23769074 68769074 Rat 2301962 Cm72 Cardiac mass QTL 72 4.12 Cardiac mass left ventricle 13 23769973 68769973 Rat 70170 Eae14 Experimental allergic encephalomyelitis QTL 14 .0024 Brain/spinal cord inflammation demyelination 13 24701710 69701710 Rat 1558644 Cm45 Cardiac mass QTL 45 3.6 .002 Cardiac mass body weight adjusted 13 25198204 70198204 Rat 6893338 Cm76 Cardiac mass QTL 76 0 .99 Cardiac mass body weight adjusted 13 25198204 70198204 Rat 61339 Bp24 Blood pressure QTL 24 .05 Blood pressure 13 25430110 46275213 Rat 1581554 Pur11 Proteinuria QTL 11 Renal function urine protein level 13 25430276 80482326 Rat 1581573 Uae36 Urinary albumin excretion QTL 36 Renal function urine albumin level 13 25430276 80482326 Rat 1581570 Eae17 Experimental allergic encephalomyelitis QTL 17 4.1 Brain/spinal cord inflammation demyelination 13 28645448 106366082 Rat 1354621 Rf47 Renal function QTL 47 3.7 Kidney renin concentration 13 32030139 105788017 Rat 2303563 Bw89 Body weight QTL 89 6 Body weight 13 34327911 79327911 Rat 61340 Bp25 Blood pressure QTL 25 4.2 .004 Blood pressure salt-loaded systolic 13 35472372 80472372 Rat 1354655 Bp241 Blood pressure QTL 241 3.9 Blood pressure systolic 13 37458331 105788017 Rat 724553 Glom3 Glomerulus QTL 3 2.9 .0004 Renal histology number of surface glomeruli (SG) 13 38179982 83179982 Rat 1331750 Bp220 Blood pressure QTL 220 2.98 Blood pressure diastolic 13 38489801 83489801 Rat 4889861 Pur29 Proteinuria QTL 29 13.8 .005 Renal function urine protein level 13 38489801 84280390 Rat 61349 Bp31 Blood pressure QTL 31 5.75 Blood pressure 13 39572400 84572400 Rat 70220 Bp55 Blood pressure QTL 55 5.75 Blood pressure 13 39572400 84572400 Rat 1549897 Stresp12 Stress response QTL 12 3.35 Stress response defensive burying - approach 13 40675437 85675437 Rat 2303032 Bp328 Blood pressure QTL 328 Blood pressure salt-loaded mean arterial 13 42627610 46912163 Rat 4145117 Mcs27 Mammary carcinoma susceptibility QTL 27 .0001 Mammary tumor susceptibility 13 44872181 49428577 Rat 6893344 Cm79 Cardiac mass QTL 79 1.5 .04 Cardiac mass body weight adjusted 13 45161605 64281346 Rat 724564 Uae11 Urinary albumin excretion QTL 11 5.7 Renal function urine albumin level 13 46269934 80482429 Rat Related Rat Strains The following Strains have been annotated to Ren SHR.BN-(D13Arb5-Ren1)/Ipcv SS.BN-(D13Rat123-D13Rat101)/Mcwi SS.BN-(D13Rat20-D13Rat127)/Mcwi Sequence Nucleotide Sequences Nucleotide RefSeqs NM_012642 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AABR06074739 (Get FASTA) Search GEO for Microarray Profiles   AAHX01075140 (Get FASTA) Search GEO for Microarray Profiles   AAHX01075141 (Get FASTA) Search GEO for Microarray Profiles   AF117820 (Get FASTA) Search GEO for Microarray Profiles   AF233692 (Get FASTA) Search GEO for Microarray Profiles   BC078878 (Get FASTA) Search GEO for Microarray Profiles   CH473958 (Get FASTA) Search GEO for Microarray Profiles   J02941 (Get FASTA) Search GEO for Microarray Profiles   M22746 (Get FASTA) Search GEO for Microarray Profiles   M37278 (Get FASTA) Search GEO for Microarray Profiles   S60054 (Get FASTA) Search GEO for Microarray Profiles   X07033 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_012642 RefSeq Status: PROVISIONAL Type: CODING Protein Acc Id: NP_036774 Peptide Label: precursor Position: Map Chr Position Strand Source RGSC Genome Assembly v5.0 13 55,555,583 - 55,566,812 - NCBI RGSC Genome Assembly v3.4 13 46,262,936 - 46,275,213 + RGD Rat Celera Assembly 13 45,129,122 - 45,139,889 + RGD Protein Sequences Protein RefSeqs NP_036774 (Get FASTA) GenBank Protein AAA42030 (Get FASTA)   AAA42031 (Get FASTA)   AAD26252 (Get FASTA)   AAF78581 (Get FASTA)   AAH78878 (Get FASTA)   AAP13916 (Get FASTA)   CAA30082 (Get FASTA)   EDM09771 (Get FASTA)   EDM09772 (Get FASTA)   P08424 (Get FASTA) Promoters RGD ID: 6849882 Promoter ID: EP29023 Type: single initiation site Name: RN_RENI Description: Renin, REN1 or REN gene. SO ACC ID: SO:0000170 Source: EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Notes: homology_group=Homology group 81; Mammalian renin Tissues & Cell Lines: kidney Experiment Methods: Primer extension with homologous sequence ladder; Primer extension; transfected or transformed cells; experiments; performed with closely related gene Position: Map Chr Position Strand Source RGSC Genome Assembly v3.4 13 46,262,926 - 46,262,986   EPD Strain Variation Strain Sequence Variants ACI/Eur (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 ACI/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN-Lx (ICL) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: SOLID Secondary Analysis: BWA, GATK, Samtools Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: MC-A654-5QB00 BN-Lx (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/NHsdMcwi (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/SsN (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Buf/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) COP/Crl (MCW & UW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Univiersity of Wisconsin (Jim Shull) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 Breeder: Charles River Grant Information: NIH (CA77876) F344/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHH/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 FHH/EurMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHL/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 GH/OmrMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 LE/Stm (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Dr. Tadao Serikawa, Kyoto Japan. Grant Information: EURATRANS (HEALTH-F4-2010-241504) M520/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) MR/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHR/Olalpcv (ICL) Visual CSV TAB Printer Sequenced By: Imperial College London (Dr Timothy Aitman) University of British Columbia (Dr. Steven Jones) Platform: Illumina Hi-seq 2000 and GAII Secondary Analysis: BWA, GATK Breeder: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague Grant Information: LSHG-CT-2005-019015, HEALTH-F4-2010-241504 SHR/Olalpcv (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: Illumina Secondary Analysis: GATK Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHRSP/Gcrc (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruch Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: University of Glasgow, Anna Dominiczak Grant Information: EURATRANS (HEALTH-F4-2010-241504) SR/JrHsd (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Breeder: Harlan SS/JrHsdMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Grant Information: R01 HL089930 SS/JrHsdMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) WKY/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) WN/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSRNOG00000002937 ENTREZGENE, UniProtKB/Swiss-Prot Ensembl Protein ENSRNOP00000003951 ENTREZGENE, UniProtKB/Swiss-Prot Ensembl Transcript ENSRNOT00000003951 ENTREZGENE, UniProtKB/Swiss-Prot Entrez Gene 24715 ENTREZGENE Gene3D-CATH Pept_Aspartc_cat UniProtKB/Swiss-Prot Germonline ENSRNOG00000002937 UniProtKB/Swiss-Prot HomoloGene Group ID 20151 ENTREZGENE IMAGE_CLONE IMAGE:7126969 IMAGE-MGC_LOAD InterPro Peptidase_A1 UniProtKB/Swiss-Prot   Peptidase_aspartic UniProtKB/Swiss-Prot   Peptidase_aspartic_AS UniProtKB/Swiss-Prot   Propep_A1 UniProtKB/Swiss-Prot IPI IPI00211210 UniProtKB/Swiss-Prot KEGG Report rno:24715 ENTREZGENE, UniProtKB/Swiss-Prot MGC_CLONE MGC:93560 IMAGE-MGC_LOAD PANTHER Peptidase_A1 UniProtKB/Swiss-Prot Pfam A1_Propeptide UniProtKB/Swiss-Prot   Asp UniProtKB/Swiss-Prot PharmGKB REN RGD PRINTS PEPSIN UniProtKB/Swiss-Prot PROSITE ASP_PROTEASE UniProtKB/Swiss-Prot Superfamily-SCOP Pept_Aspartic UniProtKB/Swiss-Prot UniGene Rn.9831 ENTREZGENE UniProt Q9R258_RAT UniProtKB/TrEMBL   RENI_RAT UniProtKB/Swiss-Prot Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2008-09-24 Ren  renin  Ren1  renin 1 structural  Nomenclature updated to reflect human and mouse nomenclature 10779 APPROVED 2008-05-15 Ren1  renin 1 structural  Ren1  renin 1  Nomenclature updated to reflect human and mouse nomenclature 10779 APPROVED 2003-04-09 Ren1  renin 1  Ren  Renin  Symbol and Name updated 2574 APPROVED 2002-06-10 Ren  Renin      Symbol and Name status set to approved 1490 APPROVED RGD Curation Notes Note Type Note Reference gene_disease affects heart mass independent of blood pressure 1357231 gene_expression expressed in the juxtaglomerular apparatus 625761 gene_regulation expression in the juxtaglomerular apparatus during low-salt diet is greatly reduced by a direct feedback inhibition through ANG II 625761

More on Ren Entrez Gene Ensembl Gene Genome Browser NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 3554 Created: 2000-05-25 Species: Rattus norvegicus Last Modified: 2013-05-14 Status: ACTIVE